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38 results on '"Chakravarthy, Krishnan V."'

1. The Neurostimulation Appropriateness Consensus Committee (NACC)®: Recommendations for Spinal Cord Stimulation Long-Term Outcome Optimization and Salvage Therapy

Author

Deer, Timothy R., Russo, Marc, Grider, Jay S., Sayed, Dawood, Lamer, Tim J., Dickerson, David M., Hagedorn, Jonathan M., Petersen, Erika A., Fishman, Michael A., FitzGerald, James, Baranidharan, Ganesan, De Ridder, Dirk, Chakravarthy, Krishnan V., Al-Kaisy, Adnan, Hunter, Corey W., Buchser, Eric, Chapman, Kenneth, Gilligan, Chris, Hayek, Salim M., Thomson, Simon, Strand, Natalie, Jameson, Jessica, Simopoulos, Thomas T., Yang, Ajax, De Coster, Olivier, Cremaschi, Fabián, Christo, Paul J., Varshney, Vishal, Bojanic, Stana, and Levy, Robert M.

Published
2024
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5. Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns

Author

Gravius, Nadine, Chaudhry, Shafqat R., Muhammad, Sajjad, Boström, Azize, Gravius, Sascha, Randau, Thomas, Scheele, Dirk, Westhofen, Philipp, Kruppenbacher, Johannes, Stoffel-Wagner, Birgit, Maier, Christian, Weidlich, Anna, Yearwood, Thomas L., Chakravarthy, Krishnan V., Kramer, Jeffery M., Hurlemann, Rene, and Kinfe, Thomas M.

Published
2019
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9. Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling

Author

Kinfe, Thomas M., Asif, Maria, Chakravarthy, Krishnan V., Deer, Timothy R., Kramer, Jeffery M., Yearwood, Thomas L., Hurlemann, Rene, Hussain, Muhammad Sajid, Motameny, Susanne, Wagle, Prerana, Nürnberg, Peter, Gravius, Sascha, Randau, Thomas, Gravius, Nadine, Chaudhry, Shafqat R., and Muhammad, Sajjad

Published
2019
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13. Re: Strand N et al. Evidence-Based Clinical Guidelines from the American Society of Pain and Neuroscience for the Use of Implantable Peripheral Nerve Stimulation in the Treatment of Chronic Pain. J Pain Res. 2022 Aug 23;15:2483–2504 [Letter]

Author

Heros,Robert D, Gilligan,Christopher J, Chakravarthy,Krishnan V, Heros,Robert D, Gilligan,Christopher J, and Chakravarthy,Krishnan V

Abstract

Robert Heros,1 Christopher J Gilligan,2 Krishnan V Chakravarthy3 1Spinal Diagnostics, Tualatin, OR, USA; 2Division of Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 3Coastal Pain and Spinal Diagnostics, San Diego, CA, USACorrespondence: Robert Heros, Spinal Diagnostics PC, Tualatin, OR, 97062, USA, Email roberth@spinaldx.com

Published
2022

19. A Review of Neuromodulation in the Treatment of Cardiovascular Disease

Author

Yang,Ajax, Chakravarthy,Krishnan V, Pope,Jason E, and Deer,Timothy

Subjects
Research Reports in Clinical Cardiology
Abstract

Ajax Yang,1 Krishnan V Chakravarthy,2 Jason E Pope,3 Timothy R Deer4 1Department of Anesthesiology, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA; 2Department of Anesthesiology and Pain Medicine, University of California San Diego Health Sciences, La Jolla, CA; VA San Diego Healthcare System, San Diego, CA, USA; 3Evolve Restorative Center, Santa Rosa, CA, USA; 4Center for Pain Relief, Charleston, WV, USACorrespondence: Timothy R DeerCenter for Pain Relief, 400 Court Street, Suite 100, Charleston, WV 25301, USATel +1304 347 6120Email tdeermd@centerforpainrelief.comIntroduction: The algorithmic use of neurostimulation to treat chronic pain is routine. However, it is underutilized in managing pain and other symptoms relating to cardiovascular dysfunctions. The goal of this article is to focus on the clinical results from using spinal cord stimulation (SCS) in the realm of cardiovascular medicine.Material and Methods: The current literature was reviewed, summarized and tabulated. This manuscript contains results from systematic reviews, randomized clinical trials and observational study search results on PubMed spanning the last 30 years. The official positioning statement from the International Neuromodulation Society Neuromodulation Appropriateness Consensus Committee (NACC) was also highlighted.Results: Evidence supports that SCS is asafe, reversible, minimally-invasive and efficacious modality to mitigate chronic symptoms of refractory angina pectoris and critical limb ischemia.Discussion: Spinal cord stimulation is effective in providing relief, improve quality of life and functional mobility in patients living with ischemic pain of systemic arterial occlusive disease.Conclusion: Spinal cord stimulation should be considered early in the treatment algorithm among individuals with inoperable ischemic pain.Keywords: angina pectoris, critical limb ischemia, ischemic pain, congestive heart failure, Reynaud’s syndrome, spinal cord stimulation

Published
2020

25. Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain

Author

Kinfe, Thomas M., Buchfelder, Michael, Chaudhry, Shafqat R., Chakravarthy, Krishnan V., Deer, Timothy R., Russo, Marc, Georgius, Peter, Hurlemann, Rene, Rasheed, Muhammad, Muhammad, Sajjad, and Yearwood, Thomas L.

Subjects
systemic inflammation, lcsh:Chemistry, lcsh:Biology (General), lcsh:QD1-999, Medizinische Fakultät, immunometabolism, neuromodulation, biomarkers development, ddc:610, chronic pain, quantitative outcome measures, lcsh:QH301-705.5
Abstract

Chronic pain is a devastating condition affecting the physical, psychological, and socioeconomic status of the patient. Inflammation and immunometabolism play roles in the pathophysiology of chronic pain disorders. Electrical neuromodulation approaches have shown a meaningful success in otherwise drug-resistant chronic pain conditions, including failed back surgery, neuropathic pain, and migraine. A literature review (PubMed, MEDLINE/OVID, SCOPUS, and manual searches of the bibliographies of known primary and review articles) was performed using the following search terms: chronic pain disorders, systemic inflammation, immunometabolism, prediction, biomarkers, metabolic disorders, and neuromodulation for chronic pain. Experimental studies indicate a relationship between the development and maintenance of chronic pain conditions and a deteriorated immunometabolic state mediated by circulating cytokines, chemokines, and cellular components. A few uncontrolled in-human studies found increased levels of pro-inflammatory cytokines known to drive metabolic disorders in chronic pain patients undergoing neurostimulation therapies. In this narrative review, we summarize the current knowledge and possible relationships of available neurostimulation therapies for chronic pain with mediators of central and peripheral neuroinflammation and immunometabolism on a molecular level. However, to address the needs for predictive factors and biomarkers, large-scale databank driven clinical trials are needed to determine the clinical value of molecular profiling.

Published
2019

33. Comprehensive Algorithm for Management of Neuropathic Pain.

Author

Bates, Daniel, Schultheis, B Carsten, Hanes, Michael C, Jolly, Suneil M, Chakravarthy, Krishnan V, Deer, Timothy R, Levy, Robert M, and Hunter, Corey W

Subjects
ANTICONVULSANTS, ANTIDEPRESSANTS, NEURALGIA, SEROTONIN uptake inhibitors, TRAMADOL, THERAPEUTIC use of transdermal medication, NONOPIOID analgesics, ALGORITHMS, ANALGESICS, ELECTRIC stimulation, HEALTH care teams, MEDICAL protocols, NARCOTICS, PHYSICIANS, PRIMARY health care, PAIN management, TREATMENT effectiveness, THERAPEUTICS
Abstract

The article provides a comprehensive algorithm for the management of neuropathic pain. Topics discussed include use of the U.S. National Library of Medicine's Medline database; the aim of the study to merge treatment guidelines and practice recommendations for management of neuropathic pain into a comprehensive algorithm for primary physicians; and the algorithm that covers assessment, multidisciplinary conservative care, and nonopioid pharmacological management.

Published
2019
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34. Nanotechnology: A Promising New Paradigm for the Control of Pain.

Author

Chakravarthy, Krishnan V., Boehm, Frank J., and Christo, Paul J.

Subjects
*DRUG toxicity, *MEDICAL information storage & retrieval systems, *INTERPROFESSIONAL relations, *MEDICAL personnel, *MEDLINE, *NANOPARTICLES, *NANOTECHNOLOGY, *ONLINE information services, *PARADIGMS (Social sciences), *PAIN management, *SYSTEMATIC reviews, *NANOMEDICINE
Abstract

Objective. The objective of this article is to critically review both preclinical and clinical studies that focus on the use of nanotechnology for both acute and chronic pain management, surveying both diagnostic and therapeutic applications. The article also provides information on nanotechnology for pain practitioners, so that they may better understand how this technology works and how it may be applied to their day-to-day clinical practice. Study Design. Narrative review. Methods. The Pubmed NCBI and EMBASE databases were utilized to review published reports of in vivo and clinical studies that focus on using nanotechnology for pain management applications in both the acute and chronic pain settings. Results. Articles were screened by title, abstract, and full article review. They were then analyzed by specific clinical indications, and appropriate data were presented based on a critical analysis of those articles. Conclusions. As the development of nanomedical applications in acute and chronic pain management continues, medical practitioners should consider their growing potential to enhance the care of patients who are consistently living with pain. Current barriers to implementation include manufacturing scale-up for commercial viability, long-term nanoparticle toxicity considerations, and high cost for successful passage through clinical trials. These challenges will need to be overcome with ongoing translational research efforts in collaboration with industry and government bodies such as the Food and Drug Administration (FDA). [ABSTRACT FROM AUTHOR]

Published
2018
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36. Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain

Author

Georgius, P, Russo, M, Kinfe Thomas M, Buchfelder Michael, Chaudhry Shafqat R, Chakravarthy Krishnan V, Deer Timothy R, Russo Marc, Georgius Peter, Hurlemann Rene, Rasheed Muhammad, Muhammad Sajjad, Yearwood Thomas L, Georgius, P, Russo, M, Kinfe Thomas M, Buchfelder Michael, Chaudhry Shafqat R, Chakravarthy Krishnan V, Deer Timothy R, Russo Marc, Georgius Peter, Hurlemann Rene, Rasheed Muhammad, Muhammad Sajjad, and Yearwood Thomas L

Abstract

Chronic pain is a devastating condition affecting the physical, psychological, and socioeconomic status of the patient. Inflammation and immunometabolism play roles in the pathophysiology of chronic pain disorders. Electrical neuromodulation approaches have shown a meaningful success in otherwise drug-resistant chronic pain conditions, including failed back surgery, neuropathic pain, and migraine. A literature review (PubMed, MEDLINE/OVID, SCOPUS, and manual searches of the bibliographies of known primary and review articles) was performed using the following search terms: chronic pain disorders, systemic inflammation, immunometabolism, prediction, biomarkers, metabolic disorders, and neuromodulation for chronic pain. Experimental studies indicate a relationship between the development and maintenance of chronic pain conditions and a deteriorated immunometabolic state mediated by circulating cytokines, chemokines, and cellular components. A few uncontrolled in-human studies found increased levels of pro-inflammatory cytokines known to drive metabolic disorders in chronic pain patients undergoing neurostimulation therapies. In this narrative review, we summarize the current knowledge and possible relationships of available neurostimulation therapies for chronic pain with mediators of central and peripheral neuroinflammation and immunometabolism on a molecular level. However, to address the needs for predictive factors and biomarkers, large-scale databank driven clinical trials are needed to determine the clinical value of molecular profiling.

37. Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain

Author

Georgius, P, Russo, M, Kinfe Thomas M, Buchfelder Michael, Chaudhry Shafqat R, Chakravarthy Krishnan V, Deer Timothy R, Russo Marc, Georgius Peter, Hurlemann Rene, Rasheed Muhammad, Muhammad Sajjad, Yearwood Thomas L, Georgius, P, Russo, M, Kinfe Thomas M, Buchfelder Michael, Chaudhry Shafqat R, Chakravarthy Krishnan V, Deer Timothy R, Russo Marc, Georgius Peter, Hurlemann Rene, Rasheed Muhammad, Muhammad Sajjad, and Yearwood Thomas L

Abstract

Chronic pain is a devastating condition affecting the physical, psychological, and socioeconomic status of the patient. Inflammation and immunometabolism play roles in the pathophysiology of chronic pain disorders. Electrical neuromodulation approaches have shown a meaningful success in otherwise drug-resistant chronic pain conditions, including failed back surgery, neuropathic pain, and migraine. A literature review (PubMed, MEDLINE/OVID, SCOPUS, and manual searches of the bibliographies of known primary and review articles) was performed using the following search terms: chronic pain disorders, systemic inflammation, immunometabolism, prediction, biomarkers, metabolic disorders, and neuromodulation for chronic pain. Experimental studies indicate a relationship between the development and maintenance of chronic pain conditions and a deteriorated immunometabolic state mediated by circulating cytokines, chemokines, and cellular components. A few uncontrolled in-human studies found increased levels of pro-inflammatory cytokines known to drive metabolic disorders in chronic pain patients undergoing neurostimulation therapies. In this narrative review, we summarize the current knowledge and possible relationships of available neurostimulation therapies for chronic pain with mediators of central and peripheral neuroinflammation and immunometabolism on a molecular level. However, to address the needs for predictive factors and biomarkers, large-scale databank driven clinical trials are needed to determine the clinical value of molecular profiling.

38. A review of the StimRouter ® peripheral neuromodulation system for chronic pain management.

Author

Regnier SM, Chen J, Gabriel RA, and Chakravarthy KV

Subjects
Humans, Pain, Pain Management, Peripheral Nerves, Quality of Life, Chronic Pain therapy, Electric Stimulation Therapy, Mononeuropathies, Transcutaneous Electric Nerve Stimulation
Abstract

The StimRouter ® peripheral nerve stimulation system created by Bioness, Inc., (CA, USA) is US FDA-approved for the treatment of peripheral mononeuropathy refractory to conservative medical management. StimRouter is a minimally invasive system that utilizes a subcutaneously implanted lead with integrated anchor and electrodes, and an external pulse generator to produce peripheral neuromodulation and achieve pain relief. Multiple published clinical trials reviewed here have shown the StimRouter system to have a high margin of safety, differentiating it from other existing peripheral neuromodulation systems requiring open surgical electrode placement and implantable pulse generators. These studies have also shown the StimRouter system to be efficacious in the treatment of multiple peripheral mononeuropathies; improving patient pain, activity levels and quality of life. StimRouter represents a feasible option for management of chronic peripheral mononeuropathy.

Published
2021
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