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152 results on '"Chakraborty, Ronith"'

2. Anticoagulation in patients with acute kidney injury undergoing kidney replacement therapy

Author

Raina, Rupesh, Chakraborty, Ronith, Davenport, Andrew, Brophy, Patrick, Sethi, Sidharth, McCulloch, Mignon, and Bunchman, Timothy

Subjects
Kidneys -- Transplantation, Anticoagulants (Medicine) -- Dosage and administration, Acute renal failure -- Care and treatment -- Demographic aspects, Health
Abstract

Kidney replacement therapy (KRT) is used to provide supportive therapy for critically ill patients with severe acute kidney injury and various other non-renal indications. Modalities of KRT include continuous KRT (CKRT), intermittent hemodialysis (HD), and sustained low efficiency daily dialysis (SLED). However, circuit clotting is a major complication that has been investigated extensively. Extracorporeal circuit clotting can cause reduction in solute clearances and can cause blood loss, leading to an upsurge in treatment costs and a rise in workload intensity. In this educational review, we discuss the pathophysiology of the clotting cascade within an extracorporeal circuit and the use of various types of anticoagulant methods in various pediatric KRT modalities., Author(s): Rupesh Raina [sup.1] [sup.2] , Ronith Chakraborty [sup.1] [sup.2] , Andrew Davenport [sup.3] , Patrick Brophy [sup.4] , Sidharth Sethi [sup.5] , Mignon McCulloch [sup.6] , Timothy Bunchman [sup.7] [...]

Published
2022
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3. Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus

Author

Raina, Rupesh, Abu-Arja, Rolla, Sethi, Sidharth, Dua, Richa, Chakraborty, Ronith, Dibb, James T., Basu, Rajit K., Bissler, John, Felix, Melvin Bonilla, Brophy, Patrick, Bunchman, Timothy, Alhasan, Khalid, Haffner, Dieter, Kim, Yap Hui, Licht, Christopher, McCulloch, Mignon, Menon, Shina, Onder, Ali Mirza, Khooblall, Prajit, Khooblall, Amrit, Polishchuk, Veronika, Rangarajan, Hemalatha, Sultana, Azmeri, and Kashtan, Clifford

Published
2022
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4. Dialysis disequilibrium syndrome (DDS) in pediatric patients on dialysis: systematic review and clinical practice recommendations

Author

Raina, Rupesh, Davenport, Andrew, Warady, Bradley, Vasistha, Prabhav, Sethi, Sidharth Kumar, Chakraborty, Ronith, and Khooblall, Prajit

Subjects
Children -- Diseases, Chronic kidney failure -- Diagnosis -- Care and treatment -- Development and progression, Practice guidelines (Medicine) -- Evaluation, Hemodialysis -- Complications and side effects, Health
Abstract

Background and objectives Dialysis disequilibrium syndrome (DDS) is a rare neurological complication, most commonly affecting patients undergoing new initiation of hemodialysis (HD), but can also be seen in patients receiving chronic dialysis who miss regular treatments, patients having acute kidney injury (AKI), and in those treated with continuous kidney replacement therapy (CKRT) or peritoneal dialysis (PD). Although the pathogenesis is not well understood, DDS is likely a result of multiple physiological abnormalities. In this systematic review, we provide a synopsis of the data available on DDS that allow for a clear picture of its pathogenesis, preventive measures, and focus on effective management strategies. Methods We conducted a literature search on PubMed/Medline and Embase from January 1960 to January 2021. Studies were included if the patient developed DDS irrespective of age and gender. A summary table was used to summarize the data from individual studies and included study type, population group, age group, sample size, patient characteristics, blood and dialysate flow rate, and overall outcome. A descriptive analysis calculating the frequency of population size, symptoms, and various treatments was performed using R software version 3.1.0. Results A total of 49 studies (321 samples) were identified and analyzed. Out of the included 49 studies, a total of 48 studies reported the presence of DSS among patients (1 study reported based on number of dialysis and therefore was not considered for analysis). Among these 48 studies, 74.3% (226/304) patients were reported to have DSS. The most common symptoms were nausea (25.2%), headache (24.8%), vomiting (23.9%), muscle cramps (18.1%), affected level of consciousness (8.8%), confusion (4.4%), and seizure (4.9%) among the 226 DDS patients. Furthermore, 12 studies decided to switch from HD to alternative dialysis modalities including continuous venovenous hemofiltration/hemodiafiltration (CVVH/CVVHDF) or PD which reported no DDS symptoms. Conclusion Early recognition and timely prevention are crucial for DDS patients. We have provided comprehensive clinical practice points for pediatric, adolescent, and young adult populations. However, it is essential to recognize that DDS was reported more frequently in the early dialysis era, as there was a lack of advanced dialysis technology and limited resources., Author(s): Rupesh Raina [sup.1] [sup.2] [sup.3] , Andrew Davenport [sup.4] , Bradley Warady [sup.5] , Prabhav Vasistha [sup.1] , Sidharth Kumar Sethi [sup.6] , Ronith Chakraborty [sup.1] [sup.2] , Prajit [...]

Published
2022
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6. Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit

Author

Raina, Rupesh, Chakraborty, Ronith, Mawby, Isabelle, Agarwal, Nirav, Sethi, Sidharth, and Forbes, Michael

Subjects
Acute renal failure -- Diagnosis -- Risk factors, Pediatric research, Health
Abstract

Background and objectives COVID-19 is responsible for the 2019 novel coronavirus disease pandemic. Despite the vast research about the adult population, there has been little data collected on acute kidney injury (AKI) epidemiology, associated risk factors, treatments, and mortality in pediatric COVID-19 patients admitted to the ICU. AKI is a severe complication of COVID-19 among children and adolescents. Methods A comprehensive literature search was conducted in PubMed/MEDLINE and Cochrane Center Trials to find all published literature related to AKI in COVID-19 patients, including incidence and outcomes. Results Twenty-four studies reporting the outcomes of interest were included. Across all studies, the overall sample size of COVID positive children was 1,247 and the median age of this population was 9.1 years old. Among COVID positive pediatric patients, there was an AKI incidence of 30.51%, with only 0.56% of these patients receiving KRT. The mortality was 2.55% among all COVID positive pediatric patients. The incidence of multisystem inflammatory syndrome in children (MIS-C) among COVID positive patients was 74.29%. Conclusion AKI has shown to be a negative prognostic factor in adult patients with COVID-19 and now also in the pediatric cohort with high incidence and mortality rates. Additionally, our findings show a strong comparison in epidemiology between adult and pediatric COVID-19 patients; however, they need to be confirmed with additional data and studies. Graphical abstract, Author(s): Rupesh Raina [sup.1] [sup.2] [sup.3] , Ronith Chakraborty [sup.1] [sup.2] , Isabelle Mawby [sup.1] , Nirav Agarwal [sup.1] , Sidharth Sethi [sup.4] , Michael Forbes [sup.5] Author Affiliations: (1) [...]

Published
2021
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7. Post-transplant Recurrence of Focal Segmental Glomerulosclerosis: Consensus Statements

Author

Raina, Rupesh, primary, Jothi, Swathi, additional, Haffner, Dieter, additional, Somers, Michael, additional, Filler, Guido, additional, Vasistha, Prabhav, additional, Chakraborty, Ronith, additional, Shapiro, Ron, additional, Randhawa, Parmjeet S., additional, Parekh, Rulan, additional, Licht, Christopher, additional, Bunchman, Timothy, additional, Sethi, Sidharth, additional, Mangat, Guneive, additional, Zaritsky, Joshua, additional, Schaefer, Franz, additional, Warady, Bradley, additional, Bartosh, Sharon, additional, McCulloch, Mignon, additional, Alhasan, Khalid, additional, Swiatecka-Urban, Agnieszka, additional, Smoyer, William E., additional, Chandraker, Anil, additional, Yap, Hui Kim, additional, Jha, Vivekananda, additional, Bagga, Arvind, additional, and Radhakrishnan, Jai, additional

Published
2023
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9. Evolution and change in paradigm of hemodialysis in children: a systematic review

Author

Chanchlani, Rahul, Young, Claire, Farooq, Aisha, Sanger, Stephanie, Sethi, Sidharth, Chakraborty, Ronith, Tibrewal, Abhishek, and Raina, Rupesh

Subjects
Hemodialysis -- Research -- Methods -- Patient outcomes, Pediatric research, Health
Abstract

Background There are similarities in hemodialysis (HD) between adults and children and also unique pediatric aspects. In this systematic review, we evaluated the existing HD literature, including vascular access, indications, parameters, and outcomes as a reflection on real-life HD practices. Methods Medline, Embase, CINAHL, Web of Science, and Cochrane Library were systematically searched for literature on HD in children (1-20 years). Two reviewers independently assessed the literature and data on indications; vascular access, outcomes, and specific parameters for HD were extracted. Results Fifty-four studies (8751 patients) were included in this review. Studies were stratified into age groups 1-5, 6-12, and 13-20 years based on median/mean age reported in the study, as well as era of publication (1990-2000, 2001-2010, and 2011-2019). Across all age groups, both arteriovenous fistulas and central venous catheters were utilized for vascular access. Congenital abnormalities and glomerulopathy were the most common HD indications. HD parameters including HD session duration, dialysate and blood flow rates, urea reduction ratio, and ultrafiltration were characterized for each age group, as well as common complications including catheter dysfunction and intradialytic hypotension. Median mortality rates were 23.3% (3.3), 7.6% (14.5), and 2.0% (3.0) in ages 1-5, 6-12, and 13-20 years, respectively. Median transplantation rates were 41.6% (38.3), 52.0% (32.0), and 21% (25.6) in ages 1-5, 6-12, and 13-20, respectively. Conclusion This comprehensive systematic review summarizes available literature on HD in children and young adults, including best vascular access, indications, technical aspects, and outcomes, and reflects on HD practices over the last three decades., Author(s): Rahul Chanchlani [sup.1] [sup.2] , Claire Young [sup.3] , Aisha Farooq [sup.3] , Stephanie Sanger [sup.3] , Sidharth Sethi [sup.4] , Ronith Chakraborty [sup.5] , Abhishek Tibrewal [sup.6] , [...]

Published
2021
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12. Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy

Author

Raina, Rupesh, Bedoyan, Jirair K., Lichter-Konecki, Uta, Jouvet, Philippe, Picca, Stefano, Mew, Nicholas Ah, Machado, Marcel C., Chakraborty, Ronith, Vemuganti, Meghana, Grewal, Manpreet K., Bunchman, Timothy, Sethi, Sidharth Kumar, Krishnappa, Vinod, McCulloch, Mignon, Alhasan, Khalid, Bagga, Arvind, Basu, Rajit K., Schaefer, Franz, Filler, Guido, and Warady, Bradley A.

Published
2020
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14. Post-transplant recurrence of focal segmental glomerular sclerosis: consensus statements

Author

Raina, Rupesh, Jothi, Swathi, Haffner, Dieter, Somers, Michael, Filler, Guido, Vasistha, Prabhav, Chakraborty, Ronith, Shapiro, Ron, Randhawa, Parmjeet S., Parekh, Rulan, Licht, Christopher, Bunchman, Timothy, Sethi, Sidharth, Mangat, Guneive, Zaritsky, Joshua, Schaefer, Franz, Warady, Bradley, Bartosh, Sharon, McCulloch, Mignon, Alhasan, Khalid, Swiatecka-Urban, Agnieszka, Smoyer, William E., Chandraker, Anil, Yap, Hui Kim, Jha, Vivekanand, Bagga, Arvind, and Radhakrishnan, Jai

Published
2024
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15. Corrigendum: PCRRT Expert Committee ICONIC position paper on prescribing kidney replacement therapy in critically sick children with acute liver failure

Author

Raina, Rupesh, primary, Sethi, Sidharth K., additional, Filler, Guido, additional, Menon, Shina, additional, Mittal, Aliza, additional, Khooblall, Amrit, additional, Khooblall, Prajit, additional, Chakraborty, Ronith, additional, Adnani, Harsha, additional, Vijayvargiya, Nina, additional, Teo, Sharon, additional, Bhatt, Girish, additional, Koh, Lee Jin, additional, Mourani, Chebl, additional, de Sousa Tavares, Marcelo, additional, Alhasan, Khalid, additional, Forbes, Michael, additional, Dhaliwal, Maninder, additional, Raghunathan, Veena, additional, Broering, Dieter, additional, Sultana, Azmeri, additional, Montini, Giovanni, additional, Brophy, Patrick, additional, McCulloch, Mignon, additional, Bunchman, Timothy, additional, Yap, Hui Kim, additional, Topalglu, Rezan, additional, and Díaz-González de Ferris, Maria, additional

Published
2022
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17. PCRRT Expert Committee ICONIC Position Paper on Prescribing Kidney Replacement Therapy in Critically Sick Children With Acute Liver Failure

Author

Raina, Rupesh, primary, Sethi, Sidharth K., additional, Filler, Guido, additional, Menon, Shina, additional, Mittal, Aliza, additional, Khooblall, Amrit, additional, Khooblall, Prajit, additional, Chakraborty, Ronith, additional, Adnani, Harsha, additional, Vijayvargiya, Nina, additional, Teo, Sharon, additional, Bhatt, Girish, additional, Koh, Lee Jin, additional, Mourani, Chebl, additional, de Sousa Tavares, Marcelo, additional, Alhasan, Khalid, additional, Forbes, Michael, additional, Dhaliwal, Maninder, additional, Raghunathan, Veena, additional, Broering, Dieter, additional, Sultana, Azmeri, additional, Montini, Giovanni, additional, Brophy, Patrick, additional, McCulloch, Mignon, additional, Bunchman, Timothy, additional, Yap, Hui Kim, additional, Topalglu, Rezan, additional, and Díaz-González de Ferris, Maria, additional

Published
2022
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19. Mapping Critical Residues in ATG11’s Coiled-Coil 2 Domain that Block Multiple Interactions and Disrupt Selective Autophagy

Author

Meyer, Mitchell D., primary, Winzeler, Jasmine, additional, Taylor, Sophia M., additional, Kilgore, Alex, additional, Edicha, Kimberly, additional, Chitwood, Chase, additional, Spearin, Zachary, additional, Silvia, S. K. Nadia Rahman, additional, Chakraborty, Ronith, additional, Smith, Jesse E., additional, Kennedy, Bridget, additional, Zois, Carson, additional, Cawthon, Hayley, additional, Gilruth, Mukiri, additional, and Backues, Steven K., additional

Published
2022
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23. Dialysis disequilibrium syndrome (DDS) in pediatric patients on dialysis: systematic review and clinical practice recommendations

Author

Raina, Rupesh, primary, Davenport, Andrew, additional, Warady, Bradley, additional, Vasistha, Prabhav, additional, Sethi, Sidharth Kumar, additional, Chakraborty, Ronith, additional, Khooblall, Prajit, additional, Agarwal, Nirav, additional, Vij, Manan, additional, Schaefer, Franz, additional, Malhotra, Kunal, additional, and Misra, Madhukar, additional

Published
2021
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27. Telemedicine for Pediatric Nephrology: Perspectives on COVID-19, Future Practices, and Work Flow Changes

Author

Raina, Rupesh, primary, Nair, Nikhil, additional, Sharma, Aditya, additional, Chakraborty, Ronith, additional, Rush, Sarah, additional, Yap, Hui Kim, additional, Sethi, Sidharth K., additional, Bagga, Arvind, additional, Hari, Pankaj, additional, Bunchman, Timothy, additional, Bartosh, Sharon, additional, Twombley, Katherine, additional, Kapur, Gaurav, additional, McCulloch, Mignon, additional, Filler, Guido, additional, Warady, Bradley A., additional, and Díaz-González de Ferris, Maria, additional

Published
2021
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30. Incidence and Outcomes of Acute Kidney Injury in COVID-19: A Systematic Review.

Author

Raina, Rupesh, Mahajan, Zubin A., Vasistha, Prabhav, Chakraborty, Ronith, Mukunda, Krishna, Tibrewal, Abhishek, and Neyra, Javier A.

Subjects
ACUTE kidney failure, RENAL replacement therapy, COVID-19, COVID-19 pandemic
Abstract

Background and Objectives: The recent worldwide pandemic of COVID-19 has been a serious, multidimensional problem that has left a detrimental worldwide impact on individuals of all ages and several organ systems. The typical manifestation of kidney involvement is acute kidney injury (AKI); however, there is a lack of consensus data regarding AKI epidemiology in COVID-19. This systematic literature review aims to bridge this knowledge gap. Design, Setting, Participants, and Measurements: MEDLINE and Cochrane library were systematically searched for the literature related to AKI in COVID-19 patients of all ages. MedRxIV was searched for relevant unpublished manuscripts. Two reviewers independently assessed the literature on the incidence of AKI and mortality, extracting the need for kidney replacement therapy (KRT). Results: Sixty studies (n = 43,871 patients) were included in this review. The pooled incidence of AKI among COVID-19 patients was 19.45% (95% confidence intervals [95% CI]: 14.63–24.77%), while the pooled incidence of AKI COVID-19 patients requiring KRT was 39.04% (16.38–64.57%). The pooled proportion of COVID+ patients was significantly lower at 8.83% (5.64% to 12/66%). The overall mortality of COVID-19 patients was calculated to be 17.71% (95% CI: 11.49–24.93%), while the mortality among patients with AKI was higher at 54.24% (95% CI: 44.70–63.63%). Conclusion: This comprehensive systematic review summarizes the available literature pertaining to AKI epidemiology in COVID-19 patients and highlights the incidence, associated mortality, and the need for KRT in this susceptible population. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross‐sectional pediatric chronic kidney disease cohort from the CKiD study

Author

Raina, Rupesh, primary, Polaconda, Shyam, additional, Nair, Nikhil, additional, Chakraborty, Ronith, additional, Sethi, Sidharth, additional, Krishnappa, Vinod, additional, Kapur, Gaurav, additional, Mhanna, Maroun, additional, and Kusumi, Kirsten, additional

Published
2020
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45. Neonatal Acute Kidney Injury: A Survey of Perceptions and Management Strategies Amongst Pediatricians and Neonatologists

Author

Sethi, Sidharth Kumar, primary, Agrawal, Gopal, additional, Wazir, Sanjay, additional, Rohatgi, Smriti, additional, Iyengar, Arpana, additional, Chakraborty, Ronith, additional, Jain, Rahul, additional, Nair, Nikhil, additional, Sinha, Rajiv, additional, Chakrabarti, Raktima, additional, Kumar, Deepak, additional, and Raina, Rupesh, additional

Published
2020
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