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1. Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

Author

Bay, Pierre, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Turpin, Matthieu, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Roux, Damien, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Levy, David, Burrel, Sonia, Mayaux, Julien, Kimmoun, Antoine, Hartard, Cédric, Pène, Frédéric, Rozenberg, Flore, Gaudry, Stéphane, Brichler, Ségolène, Guillon, Antoine, Handala, Lynda, Tamion, Fabienne, Moisan, Alice, Daix, Thomas, Hantz, Sébastien, Delamaire, Flora, Thibault, Vincent, Souweine, Bertrand, Henquell, Cecile, Picard, Lucile, Botterel, Françoise, Rodriguez, Christophe, Dessap, Armand Mekontso, Pawlotsky, Jean-Michel, Fourati, Slim, and de Prost, Nicolas

Published
2024
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2. COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

Author

Bay, Pierre, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Turpin, Matthieu, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Roux, Damien, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Levy, David, Burrel, Sonia, Mayaux, Julien, Kimmoun, Antoine, Hartard, Cédric, Pène, Frédéric, Rozenberg, Flore, Gaudry, Stéphane, Brichler, Ségolène, Guillon, Antoine, Handala, Lynda, Tamion, Fabienne, Moisan, Alice, Daix, Thomas, Hantz, Sébastien, Delamaire, Flora, Thibault, Vincent, Souweine, Bertrand, Henquell, Cecile, Picard, Lucile, Botterel, Françoise, Rodriguez, Christophe, Dessap, Armand Mekontso, Pawlotsky, Jean-Michel, Fourati, Slim, and de Prost, Nicolas

Published
2024
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3. Changes in bodyweight after initiating antiretroviral therapy close to HIV-1 seroconversion: an international cohort collaboration

Author

Moreno, Santiago, Burns, Fiona, Campo, Rafael Eduardo, Garges, Harmony, Mussini, Cristina, Pantazis, Nikos, Kamel, Moustafa, Porter, Kholoud, Sabin, Caroline, Tariq, Shema, Touloumi, Giota, Vannappagari, Vani, Anne, Alain Volny, Young, Lital, Gill, John, Carlander, Christina, Grabar, Sophie, Jarrín, Inma, Meyer, Laurence, van der Valk, Marc, Wittkop, Linda, Aisam, Agnes, Barger, Diana, Davidovich, Udi, Dos Santos, Marie, Eriksson, Lars, Fitzgerald, Eli, Karakosta, Argyro, Krentz, Hartmut, Nicholls, Emily Jay, Policek, Nicoletta, Ruiz-Burga, Elisa, Sandford, Chris, Spire, Bruno, Suárez-García, Inés, Abgrall, Sophie, Andriantsoanirina, Valerie, Avettand-Fenoel, Veronique, Bourgeois, Christine, Chaix, Marie-Laure, Cheret, Antoine, Fischer, Hugues, Goujard, Cecile, Lascoux-Combe, Caroline, Le Palec, Annie, Petrov-Sanchez, Ventzlislava, Saez-Cirion, Asier, Seng, Remonie, Stefic, Karl, Tine, Josephine, Piet, E, Gagneux-Brunon, A, Jacomet, C, Piroth, L, Benezit, F, Goussef, M, Tattevin, P, Bani Sadr, B, Lamaury, I, Bazus, H, Robineau, O, Calin, R, Katlama, J, Denis, B, Ghosn, J, Joly, V, Khuong, M A, Caby, F C, Rouveix Nordon, E, de Truchis, P, Abgrall, S, Chéret, A, Duvivier, C, Becker, A, Miailhes, P, Abel, S, Unal, G, Makinson, A, Martin-Blondel, G, Morisot, A, Bregigeon, S, Enel, P, Allavena, C, Rabier, V, Vallet, L, Marchand, L, Saïdi, T, Costagliola, D, Grabar, S, Andriantsoanirina, V, Fischer, H, Marchand T Saïdi, L, Tattevin, Pierre, de Truchis, Pierre, Fischer, Hughes, Dalmau, David, Navarro, M Luisa, González, M Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, Muñoz-Fernández, M Ángeles, Adamis, G, Chini, M, Chrysos, G, Marangos, M, Katsarou, O, Kofteridis, D, Metallidis, S, Panagopoulos, P, Papadopoulos, A, Paparizos, V, Psychogiou, M, Sambatakou, H, Sipsas, N V, Touloumi, G, Fox, Julie, Terry, Louise, Waters, Anele, Uriel, Alison, Ustianowski, Andrew, Hackney, Pamela, Fahd, Niaz, Fidler, Sarah, Ayap, Wilbert, Molina, Marcelino, Waters, Laura, Nur, Fowsiya, Fernandez, Thomas, Nugent, Diarmuid, Pinedo, Javier, Reeves, Iain, Fong, Tracy, Nicholls, Jane, Cunningham, Laura, Pangan, Jaydee, Mackintosh, Claire, Sharp, Louise, Sabin, Caroline A, Van der Valk, Marc, Jarrin, Inma, van Sighem, Ard, Volny Anne, Alain, and Costagliola, Dominique

Published
2024
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4. Low cabotegravir trough concentrations without oral lead-in in patients with HIV-1 switching to long-acting cabotegravir and rilpivirine

Author

Rubenstein, Emma, Diemer, Myriam, Goldwirt, Lauriane, Lascoux-Combe, Caroline, Chaix, Marie-Laure, Rami, Agathe, Ponscarme, Diane, Lafaurie, Matthieu, Denis, Blandine, De Castro, Nathalie, Gras, Julien, Liegeon, Geoffroy, Sellier, Pierre-Olivier, Deville, Laure, Chevret, Sylvie, Delaugerre, Constance, and Molina, Jean-Michel

Published
2024
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5. Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variants BA.2, BA.5 and BQ.1.1 in critically ill patients with COVID-19: a prospective, multicenter cohort study

Author

de Prost, Nicolas, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Bay, Pierre, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Voiriot, Guillaume, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Luyt, Charles-Edouard, Marot, Stéphane, Pène, Frédéric, Lhonneur, Anne-Sophie, Gaudry, Stéphane, Brichler, Ségolène, Picard, Lucile, Mekontso Dessap, Armand, Rodriguez, Christophe, Pawlotsky, Jean-Michel, and Fourati, Slim

Published
2023
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6. HIV transmission network analysis allows identifying unreported risk factors in HIV‐positive blood donors in France

Author

Cappy, Pierre, Chaillon, Antoine, Pillonel, Josiane, Essat, Asma, Chaix, Marie‐Laure, Meyer, Laurence, Barin, Francis, Tiberghien, Pierre, and Laperche, Syria

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Mental Health, Infectious Diseases, HIV/AIDS, Clinical Research, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Adult, Blood Donors, Blood Transfusion, Case-Control Studies, Donor Selection, Female, France, HIV Infections, HIV Seropositivity, Homosexuality, Male, Humans, Male, Middle Aged, Risk Factors, Social Network Analysis, blood donor deferral, HIV infection, public health, risk factors, transmission network, Cardiorespiratory Medicine and Haematology, Immunology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesAs sex between men is a major route of human immunodeficiency virus (HIV) infection in most western countries, restrictive deferral rules for blood donation have largely been implemented regarding men having sex with men (MSM). Here, we sought here to assign unreported HIV risk factors in blood donors (BDs) and reevaluated the MSM-associated fraction of HIV transfusion residual risk (%RRMSM ).MethodsWe applied a genetic distance-based approach to infer an HIV transmission network for 384 HIV sequences from French BDs and 1337 HIV sequences from individuals with known risk factors (ANRS PRIMO primary HIV infection cohort). We validated the possibility of assigning a risk factor according to clustering using assortative mixing. Finally, we recalculated the %RRMSM .ResultsA total of 81 of 284 (28.5%) male and 5 of 100 (5%) female BDs belonged to a cluster; 72 (88.9%) of the 81 male BDs belonged to MSM clusters. After cluster correction, 8 of 67 (11.9%), 4 of 21 (19.0%), and 19 of 88 (21.6%) HIV-positive (HIV+) male BDs with heterosexual, other, or unknown risk factors could be reclassified as MSM, accounting for 10.9% of the total HIV+ male BDs. Overall, 139 of 284 HIV+ male donors (48.9%) could be considered MSM between 2000 and 2016 in France. Between 2005 and 2016, the %RRMSM increase varied from 0 to 19%, without differing significantly from the %RRMSM before reclassification.ConclusionNetwork inference can be used to complement declaration data on risk factors for HIV infection in BDs. This approach, complementary to behavioral studies, is a valuable tool to evaluate the effect of changes in deferral criteria on BD compliance.

Published
2021

7. In-depth Sampling of High-risk Populations to Characterize HIV Transmission Epidemics Among Young MSM Using PrEP in France and Quebec

Author

Chaillon, Antoine, Delaugerre, Constance, Brenner, Bluma, Armero, Alix, Capitant, Catherine, Nere, Marie Laure, Leturque, Nicolas, Pialoux, Gilles, Cua, Eric, Tremblay, Cecile, Smith, Davey M, Goujard, Cecile, Meyer, Laurence, Molina, Jean Michel, and Chaix, Marie Laure

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, HIV/AIDS, Prevention, Infectious Diseases, Clinical Trials and Supportive Activities, Clinical Research, Pediatric, Sexual and Gender Minorities (SGM/LGBT*), Infection, Good Health and Well Being, clustering, HIV, MSM, network, PrEP, Clinical sciences, Medical microbiology
Abstract

BackgroundA better understanding of HIV transmission dynamics among populations at high risk is important for development of prevention strategies. We determined HIV transmission networks from infected individuals enrolled in the pre-exposure prophylaxis (PrEP) IPERGAY trial in combination with the ANRS PRIMO and Montreal PHI cohorts to identify and characterize active clusters of transmission in this high-risk population.MethodsGenotypic resistance tests were performed on plasma samples from 31 IPERGAY participants. Reverse transcriptase sequences were analyzed in combination with unique HIV pol sequences from 1351 individuals enrolled in the PRIMO ANRS cohort (1999-2014) and 511 individuals enrolled in the Montreal PHI cohort (1996-2016). Network analyses were performed to infer putative relationships between all participants.ResultsOverall, 1893 participants were included. Transmission network analyses revealed that 14 individuals (45.2%) from the IPERGAY trial were involved in 13 clusters sampled over a median period (interquartile range) of 2 (0.3-7.8) years, including 7 dyads and 6 larger clusters ranging from 4 to 28 individuals. When comparing characteristics between clustering individuals enrolled in the PRIMO cohort (n = 377) and in IPERGAY (n = 14), we found that IPERGAY participants had a higher viral load (5.93 vs 5.20 log10 copies/mL, P = .032) and reported a higher number of partners in the last 2 months (P < .01).ConclusionsThese results demonstrate high rates of HIV transmission clustering among young high-risk MSM enrolled in the IPERGAY trial. In-depth sampling of high-risk populations may help to uncover unobserved transmission intermediaries and improve prevention efforts that could be targeted to the most active clusters.

Published
2019

8. Viral rebound in semen after antiretroviral treatment interruption in an HIV therapeutic vaccine double-blind trial

Author

Palich, Romain, Ghosn, Jade, Chaillon, Antoine, Boilet, Valérie, Nere, Marie-Laure, Chaix, Marie-Laure, Delobel, Pierre, Molina, Jean-Michel, Lucht, Frédéric, Bouchaud, Olivier, Rieux, Véronique, Thiebaut, Rodolphe, Levy, Yves, Delaugerre, Constance, and Lelievre, Jean-Daniel

Subjects
HIV/AIDS, Clinical Trials and Supportive Activities, Pediatric, Immunization, Genetics, Clinical Research, Infectious Diseases, Vaccine Related, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Good Health and Well Being, Adult, Anti-Retroviral Agents, Blood, HIV Infections, HIV-1, Humans, Male, Middle Aged, Randomized Controlled Trials as Topic, Semen, Viral Load, Withholding Treatment, compartmentalization, HIV-DNA, HIV-RNA, male genital tract, phylogenic analysis, therapeutic vaccine trial, ultradeep sequencing, VRI02/ANRS149 LIGHT Vaccine Trial Group, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Virology
Abstract

ObjectivesThis study aimed to determine the timing and level of HIV rebound in blood and seminal plasma and to characterize the HIV rebounding populations after antiretroviral treatment interruption (ATI) in HIV-1-infected participants enrolled in a therapeutic vaccine trial.DesignA 12-week (W) ATI period was proposed at W36 to patients enrolled in the VRI02/ANRS149-LIGHT trial. Paired blood and semen samples were collected before (W32 or W36) and during ATI (W38, W40, W42, W44, and W48).MethodsHIV-RNA and HIV-DNA were quantified sequentially from blood and semen samples. Ultradeep sequencing (UDS; Roche/454) of partial env HIV-DNA/RNA (C2V3) was performed in both compartments.ResultsHIV-RNA rebounded in blood plasma and seminal plasma of all ten participants after ATI [median peak of 5.12 log10 cp/ml (range: 4.61-6.35) and 4.26 log10 cp/ml (3.20-4.67), respectively]. HIV-RNA rebound was detected in blood plasma as soon as W38 in 8/10 patients, and in seminal plasma between W38 and W40 in 8/10 patients. Phylogenetic approaches showed intermingled HIV-RNA populations from plasma and semen during ATI, suggesting a lack of viral compartmentalization between blood and semen.ConclusionOur data demonstrate rapid and high HIV rebound in semen after ATI, raising concerns about high risk of HIV sexual transmission during HIV cure trials.

Published
2019

9. Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19

Author

de Prost, Nicolas, Audureau, Etienne, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, de Montmollin, Nina, Voiriot, Guillaume, Morand-Joubert, Laurence, Joseph, Adrien, Chaix, Marie-Laure, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Luyt, Charles-Edouard, Burrel, Sonia, Mayaux, Julien, Marot, Stéphane, Roux, Damien, Descamps, Diane, Meireles, Sylvie, Pène, Frédéric, Rozenberg, Flore, Contou, Damien, Henry, Amandine, Gaudry, Stéphane, Brichler, Ségolène, Timsit, Jean-François, Kimmoun, Antoine, Hartard, Cédric, Jandeaux, Louise-Marie, Fafi-Kremer, Samira, Gabarre, Paul, Emery, Malo, Garcia-Sanchez, Claudio, Jochmans, Sébastien, Pitsch, Aurélia, Annane, Djillali, Azoulay, Elie, Mekontso Dessap, Armand, Rodriguez, Christophe, Pawlotsky, Jean-Michel, and Fourati, Slim

Published
2022
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10. Author Correction: Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19

Author

de Prost, Nicolas, Audureau, Etienne, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, de Montmollin, Nina, Voiriot, Guillaume, Morand-Joubert, Laurence, Joseph, Adrien, Chaix, Marie-Laure, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Luyt, Charles-Edouard, Burrel, Sonia, Mayaux, Julien, Marot, Stéphane, Roux, Damien, Descamps, Diane, Meireles, Sylvie, Pène, Frédéric, Rozenberg, Flore, Contou, Damien, Henry, Amandine, Gaudry, Stéphane, Brichler, Ségolène, Timsit, Jean-François, Kimmoun, Antoine, Hartard, Cédric, Jandeaux, Louise-Marie, Fafi-Kremer, Samira, Gabarre, Paul, Emery, Malo, Garcia-Sanchez, Claudio, Jochmans, Sébastien, Pitsch, Aurélia, Annane, Djillali, Azoulay, Elie, Mekontso Dessap, Armand, Rodriguez, Christophe, Pawlotsky, Jean-Michel, and Fourati, Slim

Published
2022
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11. Susceptibility to lenacapavir, fostemsavir and broadly neutralizing antibodies in French primary HIV‐1 infected patients in 2020–2023.

Author

Chaix, Marie‐Laure, Terracol, Laura, Nere, Marie‐Laure, Stefic, Karl, Lascoux‐Combe, Caroline, Manda, Victoria, Sellier, Pierre, Maylin, Sarah, Molina, Jean‐Michel, Liegeon, Geoffroy, Delaugerre, Constance, and Salmona, Maud

Subjects
NUCLEOSIDE reverse transcriptase inhibitors, REVERSE transcriptase inhibitors, INTEGRASE inhibitors, INFECTION, DRUG resistance
Abstract

Surveillance studies of Transmitted Drug Resistance (TDR) are crucial in tracking the evolution of HIV epidemiology. Our aim was to investigate TDR to nucleoside reverse transcriptase inhibitors (NRTIs), non‐nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase inhibitors (INIs), as well as to new drugs: lenacapavir, fostemsavir. Predictive sensitivity was evaluated for maraviroc and broadly neutralizing antibodies (bNAbs) (zinlirvimab and teropavimab). Between 2020 and 2023, 85 people with HIV (PWH) were diagnosed with primary HIV‐1 infection (PHI). Pol and env sequences were analyzed and TDR was characterized according to the French ANRS algorithm. The genotypic‐based prediction of bNAbs sensitivity was based on HIV env amino acid signatures I108, I201, F353 for teropavimab and N325, N332, H330 for zinlirvimab. TDR to NRTIs, NNRTIs, PIs and INIs was evidenced in 8.2%, 12.9%, 4.7%, and 5.9% strains, respectively. Ten viruses were CXCR4/dual mix. All viruses were susceptible to lenacapavir (100%) and 52% harbored resistance to fostemsavir. The genotypic profile was associated with a predictive positive value (PPV) > 83% of susceptibility to both teropavimab and zinlirvimab for 23 viruses (31%), while 22 (29%) had a PPV between 62% and 75%, suggesting reduced susceptibility to both bNAbs as soon as primary infection. The surveillance of TDR evidenced at the time of PHI is important with regard to new strategies for HIV patients with virological failure and global implementation of PrEP using NRTI, INI such as recently approved injectable cabotegravir, and future long‐acting drugs such as lenacapavir and bNAbs. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Spatiotemporal dynamics of HIV-1 transmission in France (1999–2014) and impact of targeted prevention strategies

Author

Chaillon, Antoine, Essat, Asma, Frange, Pierre, Smith, Davey M, Delaugerre, Constance, Barin, Francis, Ghosn, Jade, Pialoux, Gilles, Robineau, Olivier, Rouzioux, Christine, Goujard, Cécile, Meyer, Laurence, Chaix, Marie-Laure, and on behalf the ANRS PRIMO Cohort Study

Subjects
Microbiology, Biological Sciences, Clinical Research, Genetics, Infectious Diseases, Sexually Transmitted Infections, Sexual and Gender Minorities (SGM/LGBT*), HIV/AIDS, Prevention, 2.2 Factors relating to the physical environment, Infection, Adolescent, Adult, Aged, Cluster Analysis, Female, France, Genotype, HIV Infections, HIV-1, Humans, Male, Middle Aged, Molecular Epidemiology, Sequence Analysis, DNA, Spatio-Temporal Analysis, Young Adult, pol Gene Products, Human Immunodeficiency Virus, Transmission network, Phylogeography, Primary infection, Treatment as prevention, on behalf the ANRS PRIMO Cohort Study, Clinical Sciences, Virology
Abstract

BackgroundCharacterizing HIV-1 transmission networks can be important in understanding the evolutionary patterns and geospatial spread of the epidemic. We reconstructed the broad molecular epidemiology of HIV from individuals with primary HIV-1 infection (PHI) enrolled in France in the ANRS PRIMO C06 cohort over 15 years.ResultsSociodemographic, geographic, clinical, biological and pol sequence data from 1356 patients were collected between 1999 and 2014. Network analysis was performed to infer genetic relationships, i.e. clusters of transmission, between HIV-1 sequences. Bayesian coalescent-based methods were used to examine the temporal and spatial dynamics of identified clusters from different regions in France. We also evaluated the use of network information to target prevention efforts. Participants were mostly Caucasian (85.9%) and men (86.7%) who reported sex with men (MSM, 71.4%). Overall, 387 individuals (28.5%) were involved in clusters: 156 patients (11.5%) in 78 dyads and 231 participants (17%) in 42 larger clusters (median size: 4, range 3-41). Compared to individuals with single PHI (n = 969), those in clusters were more frequently men (95.9 vs 83%, p

Published
2017

13. Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients

Author

Vauloup-Fellous, Christelle, Maylin, Sarah, Périllaud-Dubois, Claire, Brichler, Ségolène, Alloui, Chakib, Gordien, Emmanuel, Rameix-Welti, Marie-Anne, Gault, Elyanne, Moreau, Frédérique, Fourati, Slim, Challine, Dominique, Pawlotsky, Jean-Michel, Houhou-Fidouh, Nadhira, Damond, Florence, Mackiewicz, Vincent, Charpentier, Charlotte, Méritet, Jean-François, Rozenberg, Flore, Podglajen, Isabelle, Marot, Stéphane, Petit, Heloïse, Burrel, Sonia, Akhavan, Sepideh, Leruez-Ville, Marianne, Avettand-Fenoel, Véronique, Fourgeaud, Jacques, Guilleminot, Tiffany, Gardiennet, Elise, Bonacorsi, Stéphane, Carol, Agnès, Carcelain, Guislaine, Villemonteix, Juliette, Boukli, Narjis, Gozlan, Joël, Morand-Joubert, Laurence, Legoff, Jérome, Delaugerre, Constance, Chaix, Marie-Laure, Roque-Afonso, Ana-Maria, Dortet, Laurent, Naas, Thierry, Ronat, Jean-Baptiste, Lepape, Samuel, Marcelin, Anne-Geneviève, and Descamps, Diane

Published
2021
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15. Changes in bodyweight after initiating antiretroviral therapy close to HIV-1 seroconversion: an international cohort collaboration

Author

Pantazis, Nikos, Sabin, Caroline A, Grabar, Sophie, Van der Valk, Marc, Jarrin, Inma, van Sighem, Ard, Meyer, Laurence, Carlander, Christina, Gill, John, Volny Anne, Alain, Spire, Bruno, Tariq, Shema, Burns, Fiona, Costagliola, Dominique, Ruiz-Burga, Elisa, Touloumi, Giota, Porter, Kholoud, Moreno, Santiago, Burns, Fiona, Campo, Rafael Eduardo, Garges, Harmony, Mussini, Cristina, Pantazis, Nikos, Kamel, Moustafa, Porter, Kholoud, Sabin, Caroline, Tariq, Shema, Touloumi, Giota, Vannappagari, Vani, Anne, Alain Volny, Young, Lital, Gill, John, Carlander, Christina, Grabar, Sophie, Jarrín, Inma, Meyer, Laurence, van der Valk, Marc, Wittkop, Linda, Aisam, Agnes, Barger, Diana, Davidovich, Udi, Dos Santos, Marie, Eriksson, Lars, Fitzgerald, Eli, Karakosta, Argyro, Krentz, Hartmut, Nicholls, Emily Jay, Policek, Nicoletta, Ruiz-Burga, Elisa, Sandford, Chris, Spire, Bruno, Suárez-García, Inés, Abgrall, Sophie, Andriantsoanirina, Valerie, Avettand-Fenoel, Veronique, Bourgeois, Christine, Chaix, Marie-Laure, Cheret, Antoine, Fischer, Hugues, Goujard, Cecile, Lascoux-Combe, Caroline, Le Palec, Annie, Petrov-Sanchez, Ventzlislava, Saez-Cirion, Asier, Seng, Remonie, Stefic, Karl, Tine, Josephine, Piet, E, Gagneux-Brunon, A, Jacomet, C, Piroth, L, Benezit, F, Goussef, M, Tattevin, P, Bani Sadr, B, Lamaury, I, Bazus, H, Robineau, O, Calin, R, Katlama, J, Denis, B, Ghosn, J, Joly, V, Khuong, M A, Caby, F C, Rouveix Nordon, E, de Truchis, P, Abgrall, S, Chéret, A, Duvivier, C, Becker, A, Miailhes, P, Abel, S, Unal, G, Makinson, A, Martin-Blondel, G, Morisot, A, Bregigeon, S, Enel, P, Allavena, C, Rabier, V, Vallet, L, Marchand, L, Saïdi, T, Costagliola, D, Grabar, S, Piet, E, Andriantsoanirina, V, Rabier, V, Fischer, H, Vallet, L, Marchand T Saïdi, L, Costagliola, D, Grabar, S, Abgrall, Sophie, Tattevin, Pierre, de Truchis, Pierre, Fischer, Hughes, Grabar, Sophie, Moreno, Santiago, Jarrín, Inma, Dalmau, David, Navarro, M Luisa, González, M Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, Muñoz-Fernández, M Ángeles, Adamis, G, Chini, M, Chrysos, G, Marangos, M, Katsarou, O, Kofteridis, D, Metallidis, S, Panagopoulos, P, Papadopoulos, A, Paparizos, V, Psychogiou, M, Sambatakou, H, Sipsas, N V, Touloumi, G, Fox, Julie, Terry, Louise, Waters, Anele, Uriel, Alison, Ustianowski, Andrew, Hackney, Pamela, Fahd, Niaz, Fidler, Sarah, Ayap, Wilbert, Molina, Marcelino, Waters, Laura, Nur, Fowsiya, Fernandez, Thomas, Nugent, Diarmuid, Pinedo, Javier, Reeves, Iain, Fong, Tracy, Nicholls, Jane, Cunningham, Laura, Pangan, Jaydee, Mackintosh, Claire, and Sharp, Louise

Abstract

Understanding the reasons for and consequences of bodyweight change in people living with HIV initiating antiretroviral therapy (ART) is crucial to optimising long-term health and wellbeing. We aimed to examine bodyweight trends and associated factors among individuals with well estimated dates of HIV-1 seroconversion.

Published
2024
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19. HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007–12: impact on susceptibility to first-line strategies

Author

Frange, Pierre, Assoumou, Lambert, Descamps, Diane, Chéret, Antoine, Goujard, Cécile, Tran, Laurent, Gousset, Marine, Avettand-Fenoël, Veronique, Bocket, Laurence, Fafi-Kremer, Samira, Guinard, Jerome, Morand-Joubert, Laurence, Nicot, Florence, Plantier, Jean-Christophe, Rogez, Sylvie, Wirden, Marc, Rouzioux, Christine, Meyer, Laurence, Chaix, Marie-Laure, Abel, S, Abraham, B, Allegre, T, Antoniotti, A, Armero, R, Audhuy, B, Aumaitre, H, Beaucaire, G, Beck-Wirth, G, Berger, JL, Bernard, L, Beuscart, C, Bodard, L, Bouchaud, O, Boué, F, Cabane, J-P, Cabie, A, Champagne, H, Cheneau, C, Chennebault, J-M, Cheret, A, Christian, B, Compagnucci, A, Daneluzzi, V, Debab, Y, Dellamonica, P, Delfraissy, J-F, Devidas, A, Diab, G, Doll, J, Drobacheff-Thebaut, MC, Durel, A, Duvivier, C, Esnault, J-L, Faba, L, Froguel, E, Garipuy, D, Garrait, V, Geffray, L, Genet, C, Genet, P, Gerard, L, Ghosn, J, Girard, J-J, Girard, P-M, Godin-Collet, C, Hochedez, P, Hoen, B, Houlbert, D, Jacomet, C, Jeantils, V, Jidar, K, Katlama, C, Klement, E, Lafeuillade, A, Lascoux, C, Launay, V, Lepretre, A, Levy, Y, Makhloufi, D, Malbec, D, Martha, B, May, T, Merrien, D, Miailhes, P, Miodovski, C, Molina, J-M, Morlat, P, Mortier, E, Neau, D, Obadia, M, Patey, O, Pellegrin, J-L, Perronne, V, Philibert, P, Pialoux, G, Pichancourt, G, Piroth, L, Poinsignon, Y, Poizot-Martin, I, and Prazuck, T

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, HIV/AIDS, Antimicrobial Resistance, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Anti-HIV Agents, Disease Transmission, Infectious, Drug Resistance, Viral, Female, France, Genotype, Genotyping Techniques, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, Mutation, Missense, Prevalence, resistance-associated mutations, primary HIV infection, French ANRS CO 6 PRIMO Cohort, the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups, French ANRS CO 6 PRIMO Cohort the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups, Microbiology, Pharmacology and Pharmaceutical Sciences, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

BackgroundOur study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection (PHI) in 2007-12.MethodsHIV-1 resistance-associated mutations (RAMs) were characterized using both the 2009 WHO list of mutations and the French ANRS algorithm. A genotypic susceptibility score was estimated for each first-line recommended ART combination.ResultsPatients were mainly MSM (72.6%). Non-B variants were identified in 33.7% of patients. The proportion of TDR was estimated as 11.7% (95% CI 10.0-13.5). The prevalences of PI-, NRTI-, first-generation NNRTI and etravirine/rilpivirine-associated RAMs were 2.5%, 5.2%, 3.9% and 3.2%, respectively. Single, dual and triple class resistance was found in 9.6%, 1.0% and 1.1% of cases, respectively. Additionally, 5/331 strains isolated in 2010-12 had integrase inhibitor (II)-related RAMs (isolated E157Q mutation in all cases). TDR was more common among MSM than in other groups (12.9% versus 8.6%, P = 0.034), and in case of B versus non-B subtype infections (13.6% versus 7.9%, P = 0.002). The proportions of fully active combinations were ≥99.2%, ≥97.3% and ≥95.3% in cases of PI-, II- and NNRTI-based regimens, respectively. In 2010-12, the proportion of fully active efavirenz-based ART was lower in cases of subtype B versus non-B infection (P = 0.021).ConclusionsCompared with our previous studies, the proportion of NRTI- and first-generation NNRTI-related TDR has continued to decline in French seroconverters. However, subtype B-infected MSM could drive the spread of resistant HIV strains. Finally, we suggest preferring PI- or II- to NNRTI-based combinations to treat PHI patients.

Published
2015

20. Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

Author

Rhee, Soo-Yon, Blanco, Jose Luis, Jordan, Michael R, Taylor, Jonathan, Lemey, Philippe, Varghese, Vici, Hamers, Raph L, Bertagnolio, Silvia, de Wit, Tobias F Rinke, Aghokeng, Avelin F, Albert, Jan, Avi, Radko, Avila-Rios, Santiago, Bessong, Pascal O, Brooks, James I, Boucher, Charles AB, Brumme, Zabrina L, Busch, Michael P, Bussmann, Hermann, Chaix, Marie-Laure, Chin, Bum Sik, D'Aquin, Toni T, De Gascun, Cillian F, Derache, Anne, Descamps, Diane, Deshpande, Alaka K, Djoko, Cyrille F, Eshleman, Susan H, Fleury, Herve, Frange, Pierre, Fujisaki, Seiichiro, Harrigan, P Richard, Hattori, Junko, Holguin, Africa, Hunt, Gillian M, Ichimura, Hiroshi, Kaleebu, Pontiano, Katzenstein, David, Kiertiburanakul, Sasisopin, Kim, Jerome H, Kim, Sung Soon, Li, Yanpeng, Lutsar, Irja, Morris, Lynn, Ndembi, Nicaise, Kee, Peng NG, Paranjape, Ramesh S, Peeters, Martine, Poljak, Mario, Price, Matt A, Ragonnet-Cronin, Manon L, Reyes-Terán, Gustavo, Rolland, Morgane, Sirivichayakul, Sunee, Smith, Davey M, Soares, Marcelo A, Soriano, Vincent V, Ssemwanga, Deogratius, Stanojevic, Maja, Stefani, Mariane A, Sugiura, Wataru, Sungkanuparph, Somnuek, Tanuri, Amilcar, Tee, Kok Keng, Truong, Hong-Ha M, van de Vijver, David AMC, Vidal, Nicole, Yang, Chunfu, Yang, Rongge, Yebra, Gonzalo, Ioannidis, John PA, Vandamme, Anne-Mieke, and Shafer, Robert W

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Good Health and Well Being, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Published
2015

21. Implementation of an intensive adherence intervention in patients with second-line antiretroviral therapy failure in four west African countries with little access to genotypic resistance testing: a prospective cohort study

Author

Eholie, Serge P, Moh, Raoul, Benalycherif, Aïda, Gabillard, Delphine, Ello, Frédéric, Messou, Eugène, Zoungrana, Jacques, Diallo, Ismaël, Diallo, Mouhamadou, Bado, Guillaume, Cisse, Mamadou, Maiga, Almoustapha I, Anzian, Amani, Toni, Thomas-d'Aquin, Congo-Ouedraogo, Malika, Toure-Kane, Coumba, Seydi, Moussa, Minta, Daouda K, Sawadogo, Adrien, Sangaré, Lassana, Drabo, Joseph, Karcher, Sophie, Le Carrou, Jérome, de Monteynard, Laure-Amelie, Peytavin, Gilles, Gabassi, Audrey, Girard, Pierre-Marie, Chaix, Marie-Laure, Anglaret, Xavier, and Landman, Roland

Published
2019
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22. Prevalence of pretreatment HIV resistance to integrase inhibitors in West African and Southeast Asian countries.

Author

Aghokeng, Avelin F, Ngo-Giang-Huong, Nicole, Huynh, Thu H K, Dagnra, Anoumou Y, Toni, Thomas D'Aquin, Maiga, Almoustapha I, Dramane, Kania, Eymard-Duvernay, Sabrina, Chaix, Marie-Laure, Calvez, Vincent, Descamps, Diane, and Group, ANRS12425 Study

Subjects
HIV integrase inhibitors, NON-nucleoside reverse transcriptase inhibitors, DRUG resistance, ANTIRETROVIRAL agents, MIDDLE-income countries, EBOLA virus
Abstract

Objectives Integrase strand transfer inhibitors (INSTIs) have been recently recommended as the preferred first-line option for antiretroviral treatment initiators in low- and middle-income countries (LMICs) in response to the growing circulation of resistant HIV to non-nucleoside reverse transcriptase inhibitors (NNRTIs). In this study, we estimated the frequency of pretreatment drug resistance (PDR) to INSTIs in West Africa and Southeast Asia. Materials and methods Using samples collected from 2015 to 2016, and previously used to assessed PI, NRTI and NNRTI resistance, we generated HIV integrase sequences and identified relevant INSTI PDR mutations using the Stanford and ANRS algorithms. Results We generated 353 integrase sequences. INSTI PDR frequency was low, 1.1% (4/353) overall, ranging from 0% to 6.3% according to country. However, frequency of PDR to any drug class was very high, 17.9% (95% CI: 13.9%–22.3%), and mostly associated with a high level of NNRTI PDR, 9.7%, and a moderate level of NRTI PDR, 5.3%. Conclusions Our results support the recent introduction of INSTIs in LMICs to improve treatment outcome in these settings, but also stress the need for effective actions to prevent uncontrolled emergence of drug resistance to this drug class. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial

Author

Bärnighausen, Till, Herbst, Kobus, Iwuji, Collins, Makowa, Thembisa, Naidu, Kevi, Newell, Marie-Louise, Okesola, Nonhlanhla, de Oliveira, Tulio, Pillay, Deenan, Rochat, Tamsen, Tanser, Frank, Viljoen, Johannes, Zuma, Thembelihle, McGrath, Nuala, Balestre, Eric, Dabis, François, Karcher, Sophie, Orne-Gliemann, Joanna, Plazy, Melanie, Prague, Mélanie, Thiébaut, Rodolphe, Tiendrebeogo, Thierry, Boyer, Sylvie, Donfouet, Hermann, Gosset, Andrea, March, Laura, Protopopescu, Camelia, Spire, Bruno, Calmy, Alexandra, Larmarange, Joseph, Inghels, Maxime, Diallo, Hassimiou, Calvez, Vincent, Derache, Anne, Marcelin, Anne-Geneviève, Dray-Spira, Rosemary, Lert, France, El Farouki, Kamal, Lessells, Richard, Freedberg, Kenneth, Imrie, John, Chaix, Marie-Laure, Newell, Colin, Hontelez, Jan, Bazin, Brigitte, Rekacewicz, Claire, Iwuji, Collins C, Thiebaut, Rodolphe, Dreyer, Jaco, and De Oliveira, Tulio

Published
2018
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26. Effect of isoniazid preventive therapy on risk of death in west African, HIV-infected adults with high CD4 cell counts: long-term follow-up of the Temprano ANRS 12136 trial

Author

Badje, Anani, Moh, Raoul, Gabillard, Delphine, Guéhi, Calixte, Kabran, Mathieu, Ntakpé, Jean-Baptiste, Le Carrou, Jérôme, Kouame, Gérard-Menan, Ouattara, Eric, Messou, Eugène, Anzian, Amani, Minga, Albert, Gnokoro, Joachim, Gouesse, Patrice, Emieme, Arlette, Toni, Thomas-d'Aquin, Rabe, Cyprien, Sidibé, Baba, Nzunetu, Gustave, Dohoun, Lambert, Abo, Yao, Kamagate, Synali, Amon, Solange, Kouame, Amadou-Barenson, Koua, Aboli, Kouamé, Emmanuel, Daligou, Marcelle, Hawerlander, Denise, Ackoundzé, Simplice, Koule, Serge, Séri, Jonas, Ani, Alex, Dembélé, Fassery, Koné, Fatoumata, Oyebi, Mykayila, Mbakop, Nathalie, Makaila, Oyewole, Babatunde, Carolle, Babatunde, Nathaniel, Bleoué, Gisèle, Tchoutedjem, Mireille, Kouadio, Alain-Claude, Sena, Ghislaine, Yededji, Sahinou-Yediga, Karcher, Sophie, Rouzioux, Christine, Kouame, Abo, Assi, Rodrigue, Bakayoko, Alima, Domoua, Serge-K., Deschamps, Nina, Aka, Kakou, N'Dri-Yoman, Thérèse, Salamon, Roger, Journot, Valérie, Ahibo, Hughes, Ouassa, Timothée, Ménan, Hervé, Inwoley, André, Ndja, Ben-Ahoussi, Adou, Blandine, Kanga, Constance, Aoussi, Eba, Bissagnene, Emmanuel, Ba-Gomis, Olivier, Zike, Yves-Alain, Akakpo, Claude, Sassan-Morokro, Madeleine, Mobio, Max, Doféré, Bamba, Mesmin, Koman, Attia, Alain, Mahassadi, Alassane, Horo, Apollinaire, Oussou, Armel, Chaix, Marie-Laure, Peytavin, Gilles, Koné, Mariatou, N'Guessan, Kouamé, Fassassi, Raïmi, Niangoran, Serge, Desgrées-du-Loû, Annabel, Lert, France, Dray Spira, Rosemary, Jean, Kevin, Konan, Romuald, Bohoussou, Franck, Yao-Yapi, Cyril, N'guessan-Koffi, Larissa, Siloué, Bertine, Cissé, Adoulaye, Aboua, Adrienne, Konan, Sylvie, Kouamé, Antoine, N'Chot, Celestin, Amani, Elvis, Clouet, Gwenaëlle, Debono, Bruno, Chêne, Geneviève, Dosso, Mireille, Girard, Pierre-Marie, Jarlier, Vincent, Masumbuko, Jean-Marie, Perronne, Christian, Sow, Papa-Salif, Danel, Christine, Eholié, Serge-Paul, Anglaret, Xavier, Carrou, Jérôme Le, Kouame, Gérard M, Yao, Abo, Domoua, Serge K, Menan, Hervé, and Eholié, Serge P

Published
2017
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30. High-dose corticosteroids adjusted to oxygen requirement and monitoring of serum C-reactive protein to improve outcome of non-critically ill COVID-19 patients: the CocAA-CoLa Plus Study

Author

KEVORKIAN, Jean-Philippe, primary, VANDIEDONCK, Claire, additional, LAGANIER, Jean, additional, LOPES, Amanda, additional, BURLACU, Ruxandra, additional, FERON, Florine, additional, CHAIX, Marie-Laure, additional, SENE, Damien, additional, RIVELINE, Jean-Pierre, additional, GAUTIER, Jean-François, additional, and MEGARBANE, Bruno, additional

Published
2023
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31. Prevalence and incidence of HEV among men using HIV pre-exposure prophylaxis: A sub-study of the ANRS IPERGAY trial

Author

Chaix, Marie-Laure, primary, Leturque, Nicolas, additional, Gabassi, Audrey, additional, Charreau, Isabelle, additional, Minier, Marine, additional, Pialoux, Gilles, additional, Cua, Éric, additional, Chidiac, Christian, additional, Raffi, François, additional, Tremblay, Cécile, additional, Meyer, Laurence, additional, Molina, Jean-Michel, additional, and Delaugerre, Constance, additional

Published
2023
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32. Detection of SARS-CoV-2 in Saliva and Nasopharyngeal Swabs According to Viral Variants

Author

Salmona, Maud, primary, Chaix, Marie-Laure, additional, Feghoul, Linda, additional, Mahjoub, Nadia, additional, Maylin, Sarah, additional, Schnepf, Nathalie, additional, Jacquier, Hervé, additional, Walle, Eve-Marie, additional, Helary, Marion, additional, Mellon, Guillaume, additional, Osinski, Nathalie, additional, Zebiche, Widad, additional, Achili, Yacine, additional, Amarsy, Rishma, additional, Mahé, Véronique, additional, Le Goff, Jérôme, additional, and Delaugerre, Constance, additional

Published
2022
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33. Hepatitis A and B vaccine uptake and immunisation among men who have sex with men seeking PrEP: a substudy of the ANRS IPERGAY trial

Author

Le Turnier, Paul, primary, Charreau, Isabelle, additional, Gabassi, Audrey, additional, Carette, Diane, additional, Cotte, Laurent, additional, Pialoux, Gilles, additional, Tremblay, Cécile, additional, Spire, Bruno, additional, Chaix, Marie-Laure, additional, Meyer, Laurence, additional, Capitant, Catherine, additional, Delaugerre, Constance, additional, Raffi, François, additional, and Molina, Jean-Michel, additional

Published
2022
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34. CD4 T cell decline following HIV seroconversion in individuals with and without CXCR4-tropic virus

Author

Ghosn, Jade, Bayan, Tatiana, Meixenberger, Karolin, Tran, Laurent, Frange, Pierre, d’Arminio Monforte, Antonella, Zangerle, Robert, de Mendoza, Carmen, Krastinova, Evguenia, Porter, Kholoud, Meyer, Laurence, Chaix, Marie-Laure, Kelleher, Tony, Cooper, David, Grey, Pat, Finlayson, Robert, Bloch, Mark, Kelleher, Tony, Ramacciotti, Tim, Gelgor, Linda, Cooper, David, Smith, Don, Zangerle, Robert, Gill, John, Lutsar, Irja, Chêne, Geneviève, Dabis, Francois, Thiebaut, Rodolphe, Costagliola, Dominique, Guiguet, Marguerite, Vanhems, Philippe, Chaix, Marie-Laure, Ghosn, Jade, Meyer, Laurence, Boufassa, Faroudy, Hamouda, Osamah, Meixenberger, Karolin, Bannert, Norbert, Bartmeyer, Barbara, Antoniadou, Anastasia, Chrysos, Georgios, Daikos, Georgios L., Touloumi, Giota, Pantazis, Nikos, Katsarou, Olga, Rezza, Giovanni, Dorrucci, Maria, Monforte, Antonella d’Arminio, De Luca, Andrea, Prins, Maria, Geskus, Ronald, van der Helm, Jannie, Schuitemaker, Hanneke, Sannes, Mette, Brubakk, Oddbjorn, Kran, Anne-Marte Bakken, Rosinska, Magdalena, Muga, Roberto, Tor, Jordi, de Olalla, Patricia Garcia, Cayla, Joan, del Amo, Julia, Moreno, Santiago, Monge, Susana, Del Amo, Julia, del Romero, Jorge, Pérez-Hoyos, Santiago, Sönnerborg, Anders, Bucher, Heiner C., Günthard, Huldrych, Scherrer, Alexandra, Malyuta, Ruslan, Murphy, Gary, Porter, Kholoud, Johnson, Anne, Phillips, Andrew, Babiker, Abdel, Pillay, Deenan, Morrison, Charles, Salata, Robert, Mugerwa, Roy, Chipato, Tsungai, Price, Matt A., Gilmour, Jill, Kamali, Anatoli, and Karita, Etienne

Published
2017
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37. Detection of numerous HIV-1/MO recombinants in France

Author

De Oliveira, Fabienne, Cappy, Pierre, Lemée, Véronique, Moisan, Alice, Pronier, Charlotte, Bocket, Laurence, Bouvier-Alias, Magali, Chaix, Marie-Laure, Gault, Elyanne, Morvan, Odile, Poveda, Jean-Dominique, Schneider, Véronique, Wirden, Marc, Alessandri-Gradt, Elodie, Mourez, Thomas, and Plantier, Jean-Christophe

Published
2018
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38. Predictors of CD4 cell recovery following initiation of antiretroviral therapy among HIV‐1 positive patients with well‐estimated dates of seroconversion

Author

Stirrup, OT, Copas, AJ, Phillips, AN, Gill, MJ, Geskus, RB, Touloumi, G, Young, J, Bucher, HC, Babiker, AG, Kelleher, Tony, Cooper, David, Grey, Pat, Finlayson, Robert, Bloch, Mark, Kelleher, Tony, Ramacciotti, Tim, Gelgor, Linda, Smith, Don, Zangerle, Robert, Gill, John, Lutsar, Irja, Chêne, Geneviève, Dabis, Francois, Thiebaut, Rodolphe, Costagliola, Dominique, Guiguet, Marguerite, Vanhems, Philippe, Chaix, Marie‐Laure, Ghosn, Jade, Meyer, Laurence, Boufassa, Faroudy, Hamouda, Osamah, Meixenberger, Karolin, Bannert, Norbert, Bartmeyer, Barbara, Antoniadou, Anastasia, Chrysos, Georgios, Daikos, Georgios L., Pantazis, Nikos, Katsarou, Olga, Rezza, Giovanni, Dorrucci, Maria, Monforte, Antonella, Luca, Andrea, Prins, Maria, Geskus, Ronald, Helm, Jannie, Schuitemaker, Hanneke, Sannes, Mette, Brubakk, Oddbjorn, Kran, Anne‐Marte, Rosinska, Magdalena, Muga, Roberto, Tor, Jordi, Olalla, Patricia, Cayla, Joan, Amo, Julia, Moreno, Santiago, Monge, Susana, Amo, Julia, Romero, Jorge, Pérez‐Hoyos, Santiago, Sönnerborg, Anders, Bucher, C, Günthard, Huldrych, Scherrer, Alexandra, Malyuta, Ruslan, Murphy, Gary, Porter, Kholoud, Johnson, Anne, Babiker, Abdel, Pillay, Deenan, Morrison, Charles, Salata, Robert, Mugerwa, Roy, Chipato, Tsungai, Price, Matt A., Gilmour, Jill, Kamali, Anatoli, and Karita, Etienne

Published
2018
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40. HIV incidence in the Estonian population in 2013 determined using the HIV‐1 limiting antigen avidity assay

Author

Soodla, P, Simmons, R, Huik, K, Pauskar, M, Jõgeda, E‐L, Rajasaar, H, Kallaste, E, Maimets, M, Avi, R, Murphy, G, Porter, K, Lutsar, I, Del Amo, Julia, Meyer, Laurence, Bucher, Heiner C., Chêne, Geneviève, Hamouda, Osamah, Pillay, Deenan, Prins, Maria, Rosinska, Magda, Sabin, Caroline, Touloumi, Giota, Olson, Ashley, Cartier, Andrea, Fradette, Lorraine, Walker, Sarah, Babiker, Abdel, De Luca, Andrea, Fisher, Martin, Muga, Roberto, Kelleher, Tony, Cooper, David, Grey, Pat, Finlayson, Robert, Bloch, Mark, Ramacciotti, Tim, Gelgor, Linda, Smith, Don, Zangerle, Robert, Gill, John, Dabis, Francois, Thiebaut, Rodolphe, Costagliola, Dominique, Guiguet, Marguerite, Vanhems, Philippe, Chaix, Marie‐Laure, Ghosn, Jade, Boufassa, Faroudy, Meixenberger, Karolin, Bannert, Norbert, Bartmeyer, Barbara, Antoniadou, Anastasia, Chrysos, Georgios, Daikos, Georgios L., Pantazis, Nikos, Katsarou, Olga, Rezza, Giovanni, Dorrucci, Maria, Monforte, Antonella dʼArminio, Geskus, Ronald, van der Helm, Jannie, Schuitemaker, Hanneke, Sannes, Mette, Brubakk, Oddbjorn, Kran, Anne‐Marte Bakken, Rosinska, Magdalena, Tor, Jordi, de Olalla, Patricia Garcia, Cayla, Joan, Moreno, Santiago, Monge, Susana, del Romero, Jorge, Pérez‐Hoyos, Santiago, Sönnerborg, Anders, Günthard, Huldrych, Scherrer, Alexandra, Malyuta, Ruslan, Johnson, Anne, Phillips, Andrew, Morrison, Charles, Price, Matt A., Giaquinto, Carlo, Grarup, Jesper, Kirk, Ole, Bailey, Heather, Volny Anne, Alain, Panteleev, Alex, Thorne, Claire, Aboulker, Jean‐Pierre, Albert, Jan, Asandi, Silvia, De Wit, Stéphane, Reiss, Peter, Gatell, José, Karpov, Igor, Ledergerber, Bruno, Møller, Claus, Rakhmanova, Aza, Rockstroh, Jürgen, Sandhu, Manjinder, Dedes, Nikos, Pizzuti, David, Faggion, Silvia, Raben, Dorthe, Schwimmer, Christine, and Scott, Martin

Published
2018
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41. Extraordinary Heterogeneity of Virological Outcomes in Patients Receiving Highly Antiretroviral Therapy and Monitored With the World Health Organization Public Health Approach in Sub-Saharan Africa and Southeast Asia

Author

ANRS 12186 Study Group, Aghokeng, Avelin F., Monleau, Marjorie, Eymard-Duvernay, Sabrina, Dagnra, Anoumou, Kania, Dramane, Ngo-Giang-Huong, Nicole, Toni, Thomas D., Touré-Kane, Coumba, Truong, Lien X. T., Delaporte, Eric, Chaix, Marie-Laure, Peeters, Martine, and Ayouba, Ahidjo

Published
2014
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42. SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study

Author

Fourati, Slim, primary, Audureau, Etienne, additional, Arrestier, Romain, additional, Marot, Stéphane, additional, Dubois, Claire, additional, Voiriot, Guillaume, additional, Luyt, Charles-Edouard, additional, Urbina, Tomas, additional, Mayaux, Julien, additional, Roque-Afonso, Anne-Marie, additional, Pham, Tài, additional, Landraud, Luce, additional, Visseaux, Benoit, additional, Roux, Damien, additional, Bellaiche, Raphael, additional, L’honneur, Anne-Sophie, additional, Ait Hamou, Zakaria, additional, Brichler, Ségolène, additional, Gaudry, Stéphane, additional, Salmona, Maud, additional, Clere-Jehl, Raphaël, additional, Azoulay, Elie, additional, Morand-Joubert, Laurence, additional, Marcelin, Anne-Geneviève, additional, Chaix, Marie-Laure, additional, Descamps, Diane, additional, Mekontso Dessap, Armand, additional, Rodriguez, Christophe, additional, Pawlotsky, Jean-Michel, additional, and de Prost, Nicolas, additional

Published
2022
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43. Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron, sublineages BA.1, BA.1.1, BA.2 and impact of mutational patterns in critically ill French patients with COVID-19

Author

de Prost, Nicolas, primary, Audureau, Etienne, additional, Heming, Nicholas, additional, Gault, Elyanne, additional, Pham, Tai, additional, Chaghouri, Amal, additional, de Montmollin, Nina, additional, Voiriot, Guillaume, additional, Morand-Joubert, Laurence, additional, Joseph, Adrien, additional, Chaix, Marie-Laure, additional, Préau, Sébastien, additional, Favory, Raphaël, additional, Guigon, Aurélie, additional, Luyt, Charles-Edouard, additional, Burrel, Sonia, additional, Mayaux, Julien, additional, Marot, Stéphane, additional, Roux, Damien, additional, Descamps, Diane, additional, Meireles, Sylvie, additional, Pène, Frédéric, additional, Rozenberg, Flore, additional, Contou, Damien, additional, Henry, Amandine, additional, Gaudry, Stephane, additional, Brichler, Segolene, additional, Timsit, Jean-François, additional, Kimmoun, Antoine, additional, Hartard, Cédric, additional, Louise-Marie, Jandeaux, additional, Fafi-Kremer, Samira, additional, Gabarre, Paul, additional, Emery, Malo, additional, Garcia-Sanchez, Claudio, additional, Jochmans, Sébastien, additional, Pitsch, Aurélia, additional, Rodriguez, Christophe, additional, Annane, Djillali, additional, Azoulay, Elie, additional, Mekontso-Dessap, Armand, additional, Pawlotsky, Jean-Michel, additional, and Fourati, Slim, additional

Published
2022
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44. Lopinavir/Ritonavir Monotherapy as a Nucleoside Analogue—Sparing Strategy to Prevent HIV-1 Mother-to-Child Transmission: The ANRS 135 PRIMEVA Phase 2/3 Randomized Trial

Author

ANRS 135 PRIMEVA (Protease Inhibitor Monotherapy Evaluation) Study Group, Tubiana, Roland, Mandelbrot, Laurent, Le Chenadec, Jérome, Delmas, Sandrine, Rouzioux, Christine, Hirt, Deborah, Treluyer, Jean-Marc, Ekoukou, Dieudonné, Bui, Eda, Chaix, Marie-Laure, Blanche, Stéphane, and Warszawski, Josiane

Published
2013
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49. Temporal trends of population viral suppression in the context of Universal Test and Treat: the ANRS 12249 TasP trial in rural South Africa

Author

Larmarange, Joseph, Diallo, Mamadou H., Mcgrath, Nuala, Iwuji, Collins, Plazy, Mélanie, Thiébaut, Rodolphe, Tanser, Frank, Bärnighausen, Till, Orne?Gliemann, Joanna, Pillay, Deenan, Dabis, François, Barnighausen, Till, Herbst, Kobus, Makowa, Thembisa, Naidu, Kevi, Okesola, Nonhlanhla, Oliveira, Tulio, Rochat, Tamsen, Viljoen, Johannes, Zuma, Thembelihle, Balestre, Eric, Dabis, Francois, Karcher, Sophie, Plazy, Melanie, Prague, Melanie, Thiebaut, Rodolphe, Tiendrebeogo, Thierry, Boyer, Sylvie, Donfouet, Hermann, Gosset, Andrea, March, Laura, Protopopescu, Camelia, Spire, Bruno, Calvez, Vincent, Derache, Anne, Marcelin, Anne?Genevieve, Dray?Spira, Rosemary, Lert, France, Farouki, Kamal El, Chaix, Marie?Laure, Bazin, Brigitte, Rekacewicz, Claire, Imrie, John, Lessells, Richard, Newell, Colin, Newell, Marie?Louise, Calmy, Alexandra, Freedberg, Kenneth, and Hontelez, Jan

Subjects
Time trends (Statistics) -- Analysis, Antiviral agents -- Dosage and administration, Immunosuppression -- Patient outcomes, HIV infection -- Risk factors -- Prevention, Health
Abstract

: Introduction: The universal test‐and‐treat (UTT) strategy aims to maximize population viral suppression (PVS), that is, the proportion of all people living with HIV (PLHIV) on antiretroviral treatment (ART) and virally suppressed, with the goal of reducing HIV transmission at the population level. This article explores the extent to which temporal changes in PVS explain the observed lack of association between universal treatment and cumulative HIV incidence seen in the ANRS 12249 TasP trial conducted in rural South Africa. Methods: The TasP cluster‐randomized trial (2012 to 2016) implemented six‐monthly repeat home‐based HIV counselling and testing (RHBCT) and referral of PLHIV to local HIV clinics in 2 × 11 clusters opened sequentially. ART was initiated according to national guidelines in control clusters and regardless of CD4 count in intervention clusters. We measured residency status, HIV status, and HIV care status for each participant on a daily basis. PVS was computed per cluster among all resident PLHIV (≥16, including those not in care) at cluster opening and daily thereafter. We used a mixed linear model to explore time patterns in PVS, adjusting for sociodemographic changes at the cluster level. Results: 8563 PLHIV were followed. During the course of the trial, PVS increased significantly in both arms (23.5% to 46.2% in intervention, +22.8, p < 0.001; 26.0% to 44.6% in control, +18.6, p < 0.001). That increase was similar in both arms (p = 0.514). In the final adjusted model, PVS increase was most associated with increased RHBCT and the implementation of local trial clinics (measured by time since cluster opening). Contextual changes (measured by calendar time) also contributed slightly. The effect of universal ART (trial arm) was positive but limited. Conclusions: PVS was improved significantly but similarly in both trial arms, explaining partly the null effect observed in terms of cumulative HIV incidence between arms. The PVS gains due to changes in ART‐initiation guidelines alone are relatively small compared to gains obtained by strategies to maximize testing and linkage to care. The achievement of the 90‐90‐90 targets will not be met if the operational and implementational challenges limiting access to care and treatment, often context‐specific, are not properly addressed. Clinical trial number: NCT01509508 (clinicalTrials.gov)/DOH‐27‐0512‐3974 (South African National Clinical Trials Register)., Introduction Antiretroviral treatment (ART), when taken early has several benefits, both in terms of morbidity and mortality and in terms of reduction in HIV sexual transmission. Mathematical modelling work suggested [...]

Published
2019
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50. Impact on disease mortality of clinical, biological, and virological characteristics at hospital admission and overtime in COVID‐19 patients

Author

Yazdanpanah, Yazdan, DIALLO, Alpha, PAUL, Christelle, MERCIER, Noémie, LE MESTRE, Soizic, PETROV‐SANCHEZ, Ventzislava, ANDREJAK, Claire, CHIROUZE, Catherine, MALVY, Denis, DEPLANQUE, Dominique, DUBOS, François, ROSSIGNOL, Patrick, ETIENNE, Manuel, ROSSIGNOL, Bénédicte, LEVY‐MARCHAL, Claire, GILG, Morgane, GIGANTE, Tristan, Marine, BELUZE, HULOT, Jean‐Sebastien, CHAIR, Anissa, KHALIL, Antoine, VISSEAUX, Benoit, COUFFIGNAL, Camille, ROY, Carine, LAOUÉNAN, Cédric, DA SILVEIRA, Charlene, TARDIVON, Coralie, BACHELET, Delphine, DESCAMPS, Diane, MENTRÉ, France, BOMPART, François, LESCURE, François‐Xavier, PEYTAVIN, Gilles, GORENNE, Isabelle, HOFFMANN, Isabelle, GHOSN, Jade, Christophe LUCET, Jean, TIMSIT, Jean‐François, MULLAERT, Jimmy, BHAVSAR, Krishna, BOUADMA, Lila, TAGHERSET, Lysa, TELLIER, Marie‐Capucine, DEBRAY, Marie‐Pierre, ESPOSITO‐FARESE, Marina, SCHNEIDER, Marion, LE, Minh, ETTALHAOUI, Nadia, SI MOHAMMED, Nassima, GAULT, Nathalie, PEIFFER‐SMADJA, Nathan, KEFIF, Ouifiya, ELOY, Philippine, LE HINGRAT, Quentin, KALI, Sabrina, LARIBI, Samira, TUBIANA, Sarah, TRIOUX, Théo, DUVAL, Xavier, VANEL, Noémie, PICONE, Olivier, BASMACI, Romain, ANGOULVANT, François, KAGUELIDOU, Florentia, PAGES, Justine, VEISLINGER, Aurélie, TUAL, Christelle, PAPADOPOULOS, Aurélie, ESPEROU, Hélène, JAAFOURA, Salma, COUFFIN‐CADIERGUES, Sandrine, COELHO, Alexandra, HOCTIN, Alexandre, DIOUF, Alphonsine, MAMBERT, Marina, GAYMARD, Alexandre, LINA, Bruno, ROSA‐CALATRAVA, Manuel, BOUSCAMBERT, Maude, TERRIER, Olivier, MEZIANE, Amina, DORIVAL, Céline, BENKEROU, Dehbia, TÉOULÉ, François, LINGAS, Guillaume, LE NAGARD, Hervé, GUEDJ, Jérémie, NEANT, Nadège, ABEL, Laurent, KHAN, Coralie, DESVALLÉE, Mathilde, WIEDEMANN, Aurélie, LEVY, Yves, MOUQUET, Hugo, BEHILILL, Sylvie, van der WERF, Sylvie, ENOUF, Vincent, SEMAILLE, Caroline, dORTENZIO, Eric, CERVANTES‐GONZALEZ, Minerva, PUÉCHAL, Oriane, NORET, Marion, RORIZ, Mélanie, RISPAL, Patrick, REDL, Sarah, LEFEBVRE, Laurent, GRANIER, Pascal, MAULIN, Laurence, JOSEPH, Cédric, MOYET, Julien, LION‐DAOLIO, Sylvie, MAHIEU, Rafael, DUCANCELLE, Alexandra, DUBEE, Vincent, SALLABERRY, Stéphane, MANUEL, Aldric, MACHEDA, Gabriel, MAILLET, Mylène, CHANZY, Bruno, GAGNARD, Jean‐Charles, GIORDANO, Guillermo, MOUTON PERROT, Clara, PESTRE, Vincent, FICKO, Cécile, GOMINET, Marie, BOUSQUET, Aurore, VAUCHY, Charline, BOUILLER, Kévin, PAGADOY, Maïder, MARTY‐QUINTERNET, Solène, LEPILLER, Quentin, LE BRIS, Cyril, THILL, Benoit, CASANOVA, Marie‐Laure, LE FALHER, Georges, OZIOL, Eric, CORDEL, Hugues, DOURNON, Nathalie, BOUCHAUD, Olivier, BRICHLER, Ségolène, NGUYEN, Duc, BELLECAVE, Pantxika, CICCONE, Camille, LAFON, Marie‐Edith, GREFFE, Ségolène, BOUISSE, Camille, SEDILLOT, Nicholas, BOUHOUR, Damien, CHASSIN, Camille, LHER, Erwan, ANSART, Séverine, TROMEUR, Cécile, GUELLEC, Dewi, MERCKX, Antoine, DJOSSOU, Felix, PEIGNE, Vincent, PIEROBON, Carola, CARRET, Marie‐Christine, JEGO, Florence, ISNARD, Margaux, AUCHABIE, Johann, COURTOIS, Roxane, LESENS, Olivier, MARTINOT, Martin, LACOSTE, Marie, ELHARRAR, Brigitte, GARRAIT, Valérie, DELACROIX, Isabelle, MAITRE, Thomas, Baptiste ASSIE, Jean, NYAMANKOLLY, Elsa, Xavier CATHERINE, François, BLOT, Mathieu, MAHY, Sophie, BUISSON, Marielle, PIROTH, Lionel, GUILLOTIN, Florence, DE ROUGEMONT, Alexis, CAMPANA, Valentine, PASQUIER, Jérémie, CABIE, André, BESSIS, Simon, EPAULARD, Olivier, TERZI, Nicolas, PAYEN, Jean‐François, BOUILLET, Laurence, HAMIDFAR, Rebecca, Le MARECHAL, Marion, MACHADO, Moïse, BARRELET, Audrey, BEDOSSA, Alexandra, COLIN, Gwenhaël, DECOURS, Romain, GUIMARD, Thomas, GOUJARD, Cécile, JAUREGUIBERRY, Stéphane, CHERET, Antoine, Sophie RESSEGUIER, Anne, POISSY, Julien, MATHIEU, Daniel, NSEIR, Saad, ENGELMANN, Ilka, REMY, Martine, VUOTTO, Fanny, GACHET, Benoit, FAURE, Karine, BOYER‐BESSEYRE, Marielle, Enagnon, Kazali, LAMBERT, Marc, SCHERPEREEL, Arnaud, FRY, Stéphanie, YELNIK, Cécile, BITKER, Laurent, MEZIDI, Mehdi, YONIS, Hodane, BENECH, Nicolas, PERPOINT, Thomas, CONRAD, Anne, ICARD, Vinca, VALETTE, Martine, THIBERVILLE, Simon‐Djamel, REBAUDET, Stanislas, DUSSOL, Bertrand, DIAMANTIS, Sylvain, CHAKVEATZE, Catherine, FLATEAU, Clara, DINOT, Vincent, GACI, Rostane, OUAMARA, Nadia, ILLES, Hajnal‐Gabriela, GERBAUD MORLAES, Louis, DIMET, Jérôme, LE MOING, Vincent, PANSU, Nathalie, LE BIHAN, Clément, MONTES, Brigitte, Sophie BOUREAU, Anne, ALLAVENA, Clotilde, BOUCHEZ, Sabelline, GUERY, Romain, LE TURNIER, Paul, MEAR‐PASSARD, Cécile, FERRE, Virginie, RAPP, Christophe, DEMONCHY, Elisa, MICHELANGELLI, Céline, RISSO, Karine, LOUBET, Paul, LAVIGNE, Jean‐Phillippe, DE MONTMOLLIN, Etienne, PATRIER, Juliette, Henri WICKY, Paul, LE FEVRE, Lucie, JACQUET, Pierre, BORIE, Raphael, DOSSIER, Antoine, LUTON, Dominique, ISERNIA, Valentina, LE GAC, Sylvie, AZOULAY, Cécile, CARLIER, Nicolas, LUONG, Liem, LACHATRE, Marie, LAUNAY, Odile, KERROUMI, Younes, MEYSSONNIER, Vanina, DIEHL, Jean‐Luc, HULOT, Jean‐Sébastien, CHOLLEY, Bernard, ARLET, Jean‐Benoît, SANCHEZ, Olivier, MANDA, Victoria, AZEMAR, Laurène, CASTOR‐ALEXANDRE, Guylaine, LACOMBE, Karine, CHIARABINI, Thibault, LEFEBVRE, Bénédicte, MORAND‐JOUBERT, Laurence, FOFANA, Djeneba, SCHNURIGER, Aurélie, DE CASTRO, Nathalie, DELAUGERRE, Constance, CHAIX, Marie‐Laure, CHAS, Julie, GABORIEAU, Valérie, LE COUSTUMIER, Eve, PICARD, Walter, ZABBE, Jean‐Benoît, PEELMAN, Florent, SOUM, Edouard, AUMAÎTRE, Hugues, CURLIER, Elodie, OUISSA, Rachida, FABRE, Isabelle, RAMMAERT, Blandine, SAIDANI, Nadia, BANI‐SADR, Firouzé, HENTZIEN, Maxime, NGUYEN, Yohan, ROMARU, Juliette, DIDIER, Kévin, ENDERLE, Isabelle, THIBAULT, Vincent, LAINE, Fabrice, LESOUHAITIER, Matthieu, REVEST, Matthieu, TATTEVIN, Pierre, PLANTIER, Jean‐Christophe, LEMEE, Véronique, FERRAND DEVOUGE, Eglantine, ALEXANDRE, Kévin, ARTAUD‐MACCARI, Elise, ALLOU, Nathalie, LAGRANGE, Marie, JABOT, Julien, ROZE, Benoît, BREGEAUD, Delphine, AIT TAMLIHAT, Younes, HACHEMI, Ali, SALVATOR, Hélène, FOURN, Erwan, ZUCMAN, David, DELAVEUVE, Eric, JAUD‐FISCHER, Coline, DUNAND, Paul, BISSUEL, François, DELAVIGNE, Karen, PIEL‐JULIAN, Marie, DELOBEL, Pierre, SARTON, Benjamine, RAFIQ, Marie, MARTIN‐BLONDEL, Guillaume, GUILLEMINAULT, Laurent, MURRIS, Marlène, SOMMET, Agnès, SENNEVILLE, Eric, ROBINEAU, Olivier, MEYBECK, Agnès, GAROT, Denis, PLANTIER, Laurent, GISSOT, Valérie, MARLET, Julien, STEFIC, Karl, GAUDY‐GRAFFIN, Catherine, BARIN, Francis, LEMAIGNEN, Adrien, CORVAISIER, Grégory, LARIVIERE, Delphine, LANGELOT‐RICHARD, Marie, BOTELHO‐NEVERS, Elisabeth, GAGNEUX‐BRUNON, Amandine, TROUILLON, Tiffany, BOURLET, Thomas, PILLET, Sylvie, POZZETTO, Bruno, KIMMOUM, Antoine, LEVY, Bruno, MATTEI, Mathieu, GOEHRINGER, François, RABAUD, Christian, BEVILACQUA, Sibylle, LEFEVRE, Benjamin, GUILLAUMOT, Anne, VENARD, Véronique, JEULIN, Hélène, SCHVOERER, Evelyne, HARTARD, Cédric, CARAUX PAZ, Pauline, RICHIER, Laurent, EL SANHARAWI, Mohamed, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, ANRS France Recherche Nord & sud Sida-hiv hépatites, France REcherche Nord & sud Sida-hiv Hépatites (FRENSH), CHU Amiens-Picardie, Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, French COVID cohort study group, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC Lille), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), CHU Rouen, Normandie Université (NU), and The Alliance for International Medical Action [Dakar, Sénégal] (ONG ALIMA)

Subjects
Adult, Male, medicine.medical_specialty, Multivariate analysis, Adolescent, prospective cohort, SARS‐CoV‐2, Cohort Studies, Young Adult, coronavirus disease 2019, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, Risk Factors, Virology, Internal medicine, Diabetes mellitus, emerging infection diseases, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Research Articles, Aged, Aged, 80 and over, SARS-CoV-2, Proportional hazards model, business.industry, Hazard ratio, Age Factors, COVID-19, Middle Aged, Viral Load, medicine.disease, Obesity, Confidence interval, Hospitalization, Infectious Diseases, Female, 030211 gastroenterology & hepatology, France, business, Viral load, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract

Little is known on the association between clinical factors and coronavirus disease 2019 (COVID‐19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID‐19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, according to mortality up to Day 60 after admission. For the analysis of risk factors of survival, analyses assessing associations between mortality and demographic characteristics or comorbidities were performed using a Cox regression model. Between January 24 and March 15, 2020, 246 patients with reverse‐transcriptase polymerase chain reactions virologically confirmed COVID‐19 were enrolled. In multivariate analysis, mortality at Day 60 (n = 42 patients, 17.1% [95% confidence interval, 12.6–22.4]) was associated with older age (adjusted hazard ratio [aHR] for age ≥ 65 years: 5.22 [2.56–10.63, p, Highlights Older age, male gender, chronic pulmonary disease (not asthma), obesity, and diabetes were associated with mortality in COVID‐19 hospitalized patients. Viral load at admission decreased with the time since symptom onset, with an association with mortality adjusted on clinical risk factors.

Published
2020

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