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2. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial
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Pracoń, Radosław, Spertus, John A., Broderick, Samuel, Bangalore, Sripal, Rockhold, Frank W., Ruzyllo, Witold, Demchenko, Elena, Nageh, Thuraia, Grossman, Gabriel Blacher, Mavromatis, Kreton, Manjunath, Cholenahally N., Smanio, Paola E.P., Stone, Gregg W., Mancini, G.B. 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Arunima, Huda, Zohra, Wall, Matthew, Boan, Araceli, Lenges De Rosen, Veronica, Alam, Mahboob, Turner, Michael C., Hinton, Christine R, Mulhearn, Thomas J., Good, Arnold P., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Nicolas W., Shammas, Gail A, Christensen, Lori, Park, Holly, Chilton, Robert, Hecht, Joan, Nguyen, Patricia K., Vo, Davis, Hirsch, James, Jezior, Matthew, Bindeman, Jody, Salkind, Sara, Espinosa, Dalisa, Desimone, Lori-Ann, Gordon, Paul C., Felix-Stern, Lina, Crain, Thomas, Gomes, Jassira, Gordon, Catherine, Stenberg, Robert, Mann, Aimee, McCreary, Theresa, Pedalino, Ronald P., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Wiesel, Joseph, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Juang, George J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Al-Amoodi, Mohammed, Zambrano, 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Chakanalil Govindan, Sajeev, Raj, Janitha, Gopalan Nair, Rajesh, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Moorthy, Nagaraja, Nayak, Soundarya, Mylarappa, Mahevamma, Narayanappa, Suryaprakash, Pandit, Neeraj, Bajaj, Sheromani, Kumar Nath, Ranjit, Yadav, Vandana, Mishra, Girish, Dwivedi, S.K., Tewari, Roma, Narain, V.S., Mishra, Meenakshi, Chandra, Sharad, Patel, Shivali, Singh, Suman, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Kaur, Baljeet, Aslam, Naved, Gupta, Sonika, Goyal, Abhishek, Bhargava, Balram, Suvarna, Chandini, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V K, Mathew, Anoop, Mannekkattukudy Kurian, Binoy, Punnoose, Eapen, Avdhoot Gadkari, Milind, Rupesh Karwa, Sheetal, Gadage, Siddharth, Kolhe, Suvarna, Umesh Pillay, Tapan, Satheesh, 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A., Oliveira, Natalia S, Lima, Rodolfo G. S. D, Figueiredo, Estevao, Edilena Paulino Azevedo, Bruna, Ricardo Caramori, Paulo, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Tumelero, Rogerio, Laimer, Rosane, Tognon, Alexandre, Dall’Orto, Frederico, Mesquita, Claudio T., Santos, Roberta P, Colafranseschi, Alexandre S., Oliveira, Amarino C., Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., Eustáquio Ribeiro da Silva, Expedito, Gabriel Melo de Barros e Silva, Pedro, Yumi Okada, Mariana, de Pádua Silva Baptista, Luciana, Paula Batista, Ana, Jamus Rodrigues, Marcelo, Nogueira Rabaça, Aline, Valério Coimbra de Resende, Marcos, Francisco Saraiva, Jose, Miranda Trama, Larissa, Silva, Talita, Thais de Souza Ormundo, Camila, Vicente, Carla, Costantini, Costantino, Pinheiro, Caroline, Komar, Daniele, Szwed, Hanna, Demkow, Marcin, Kepka, Cezary, Teresinska, Anna, Walesiak, Olga, Kryczka, Karolina, Malinowska, Katarzyna, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Swiderek, Marta, Fratczak, Aleksandra, Wojtala, Ewelina, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Szwed, Hanna, Karwowski, Jaroslaw, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Łabyk, Andrzej, Roik, Marek, Szramowska, Agnieszka, Zdończyk, Olga, Łoboz-Grudzień, Krystyna, Jaroch, Joanna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kolodziej, Adam, Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Bockeria, Leo, Bockeria, Olga, Petrosyan, Karen, Kudzoeva, Zalina, Trifonova, Tatiana, Aripova, Nodira, Chernyavskiy, Alexander M., Naryshkin, Ivan A., Kretov, Evgeniy I., Kuleshova, Alena, Grazhdankin, Igor O., Malaev, Dastan, Bershtein, Leonid L., Sayganov, Sergey A., Subbotina, Irina, Kuzmina-Krutetskaya, Anastasia M., Gumerova, Victoria, Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Nikolaeva, Olga B., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Luis Lopez-Sendon, Jose, Castro, Almudena, Lopez-Sendon, Jose, Fernández-Figares, Virginia, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Blanco-Calvo, Moisés, Cuenca-Castillo, José J, Alonso-Álvarez, Encarnación, Flores-Ríos, Xacobe, García-González, Paula, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Seijas Amigo, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Fernández Martínez, Ana, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Igual, Begoña, Diez, Jose L, Calvillo, Pilar, Ortuño, F. Marin, Valdés Chávarri, M., Quintana Giner, M., Tello Montolliu, A., Romero Aniorte, A.I., Pinar Bermudez, E., Rivera Caravaca, JM., De La Morena, G., Gracida Blancas, Montserrat, Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Enrique Castillo Luena, Jose, Enrique Castillo Luena, Jose, Lasala, Maria, Fernandez-Aviles, Francisco, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Jiang, Lixin, Chen, Jiyan, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Wu, Yongjian, Tian, Yanmeng, Li, Dongze, Ma, Yitong, Li, Xiaomei, Yang, Yining, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Ji, Zheng, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Yang, Xinchun, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Lin, Wenhua, Jing, Rui, Liu, Jingjing, Zeng, Hesong, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Fu, Xin, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Yang, Bin, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, 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M., Dongen, Elise van, Janzen, Elisabeth M., Niehe, Sander R., Suryapranata, Harry, Ahoud, Sandra, Vugt, Stijn van, Ramos, Ruben, Santa Marta, Hospital de, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Selas, Mafalda, Bernanrdes, Luis, Silva, Filipa, Rio, Pedro, Freixo, Cláudia, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Cabrita, Inês Zimbarra, Menezes, Miguel Nobre, Rocha, Andreia, Lopes, Guilhermina Cantinho, Figueiras, Francisca Patuleia, Almeida, Ana Gomes, Coelho, Andreia, CanVas Silva, Pedro, Capinha, Marta, Nobre, Angelo, Caetano, Maria Inês, Francisco, Ana Rita, Silva, Susana, Ferreira, Nuno, de Gaia, Vila Nova, Lopes, Ricardo L., Diaz, Rafael, Guzman, Luis, Tinnirello, Veronica, Figal, Julio César, Nicolás Mungo, Matías, Buenos Aires, Ciudad Autonoma de, Méndiz, Oscar, Cortés, Claudia, Favaloro, Roberto René, Alvarez, Carlos, Garcia, Marina, Blanca, Bahia, Courtis, Javier, Godoy, Valeria, Zeballos, Gabriela, Schiavi, Lilia, Actis, Maria Victoria, Rubio, Mariano, Scaro, Graciela, White, Harvey Douglas, Alsweiler, Caroline, Devlin, Gerard Patrick, Low, Liz, Fisher, Raewyn, Scales, Jayne, Abercrombie, Kirsty, Stewart, Ralph Alan Huston, Howell, Leah, White, Harvey Douglas, Patten, Cathrine, Benatar, Jocelyne, Kedev, Sasko, Mitevska, Irena Peovska, Kostovska, Elizabeta Srbinovska, Pejkov, Hristo, Held, Claes, Held, Claes, Eggers, Kai, Frostfelt, Gunnar, Björklund, Christina, Johnston, Nina, Andreasson, Maria, Olsowka, Maciej, Essermark, Marie, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Persson, Liselotte, Beyar, Rafael, Sharir, Tali, Nikolsky, Eugenia, Sharir, Tali, Harel, Or, Elian, Dan, Kerner, Arthur, Bentzvi, Margalit, Massalha, Samia, Helmer, Ludmila, Kohsaka, Shun, Fukuda, Keiichi, Ueda, Ikuko, Kohsaka, Shun, Fujita, Jun, Yasuda, Satoshi, Furukawa, Akemi, Hirase, Kanae, Nagai, Toshiyuki, Otsuka, Fumiyuki, Nishimura, Shigeyuki, Nakano, Shintaro, de Werf, Frans Van, Goetschalckx, Kaatje, Goetschalckx, Kaatje, Robesyn, Valerie, de Werf, Frans Van, Claes, Kathleen, White, Harvey Douglas, Alsweiler, Caroline, Hung, Chung-Lieh, Yang, Yi-Hsuan, Yun, Chun-Ho, Hou, Charles Jia-Yin, Kuo, Jen-Yuan, Yeh, Hung-I, Hung, Ta-Chuan, Li, Jiun-Yi, Chien, Chen-Yen, Tsai, Cheng-Ting, Liu, Chun-Chieh, Yu, Fa-Chang, Lin, Yueh-Hung, Lan, Wei-Ren, Yen, Chih-Hsuan, Tsai, Jui-Peng, Sung, Kuo-Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Philander (Nee Talliard), Constance, Viljoen, Charle A, Mtana, Noloyiso, De Andrade, Marianne, Maggioni, Aldo P., Moccetti, Tiziano, Anesini, Adriana, Rossi, M.Grazia, Maspoli, Simona, Mombelli, Manuela, Abdelhamid, Magdy, Talaat, Ahmed, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, Kaffas, Sameh El, Fishawy, Hussien El, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Rosca, Monica, Deleanu, Dan, Beladan, Carmen C., Iliescu, Vlad A., Al-Mallah, Mouaz H., Zahrani, Sarah, Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Mogrovejo Ramos, Walter Enrique, Monsalve Davila, Marco Antonio, White, Harvey Douglas, Alsweiler, Caroline, Kuanprasert, Srun, Mai, Chiang, Prommintikul, Arintaya, Nawarawong, Weerachai, Khwakhong, Supatchara, Woragidpoonpol, Surin, Chaiyasri, Anong, Tepsuwan, Thitipong, Mekara, Warangkana, Taksaudom, Noppon, Kulthawong, Supap, Rimsukcharoenchai, Chataroon, Amaritakomol, Anong, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Panpunuan, Pachara, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, White, Harvey Douglas, Alsweiler, Caroline, Khairuddin, Ahmad, Mokhtar, Noor Syamira, Hadi, Hafidz Abd, Basri, Nor Asiah, Yahaya, Shaiful Azmi, Yusnida, Irni, Hashim, Humayrah, Harrington, Robert, Williams, David, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, Mark, Daniel, O’Brien, Sean M., Rosenberg, Yves, Shaw, Leslee J., Ballantyne, Christie, Berman, Daniel, Beyar, Rafael, Bhargava, Balram, Buller, Chris, (Tony) Carvalho*, Antonio, Chaitman, Bernard R., Diaz, Rafael, Doerr, Rolf, Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Hachamovitch, Rory, Hamm, Christian, Held, Claes, Helm, Malte, Huber, Kurt, Jiang, Lixin, Keltai, Matyas, Kohsaka, Shun, Lang, Irene, Lopes, Renato, Lopez-Sendon, Jose, Maggioni, Aldo, Bairey Merz, C. Noel, Min, James, Peterson, Eric, Picard, Michael H., Selvanayagam, Joseph, Senior, Roxy, Sharir, Tali, Steg, Gabriel, Szwed, Hanna, de Werf, Frans Van, Weintraub, William, White, Harvey, Williams, David, Ballantyne, Christie, Calfas*, Karen, Chaitman, Bernard R., Champagne, Mary Ann, Davidson, Michael, Fleg, Jerome, McCullough, Peter A., Stone, Peter, Menasche, Philippe, Davidson*, Michael, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Williams, David, Blankenship, Jim, Brener, Sorin, Buller, Chris, Colombo, Antonio, Bruyne, Bernard de, Généreux, Philippe, Harrington, Robert, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Mahaffey, Ken, White, Harvey, Chaitman, Bernard R., Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Alexander, Karen P., Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Shaw, Leslee J., Berman, Daniel, Friedrich, Matthias, Hachamovitch, Rory, Kwong, Raymond, Min, James, Oliver, Dana, Picard, Michael H., Harrell, Frank, Blume, Jeffrey, Lee, Kerry, O’Brien, Sean M., Berger, Jeffrey, Held, Claes, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Mark, Daniel, Cohen, David, Weintraub, William, Merz, C. Noel Bairey, Bugiardini, Raffaele, Celutkiene, Jelena, Escobedo, Jorge, Hoye, Angela, Lyubarova, Radmila, Mattina, Deirdre, Peteiro, Jesus, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, O’Brien, Sean M., Rosenberg, Yves, Mark, Daniel, Mark, Daniel, Shaw, Leslee J., Berman, Dan, Chaitman, Bernard R., Fleg, Jerome, Kwong, Raymond, Picard, Michael H., Senior, Roxy, Min, James, Leipsic, Jonathan, Ali, Ziad, Williams, David, Fleg, Jerome, Berger, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Alexander, Karen P., Fleg, Jerome, Mathew, Roy, O’Brien, Sean M., Sidhu, Mandeep, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Gibson, C. 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James, Hyun, Mark, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Kwong, Raymond Y., Friedrich, Matthias, Mongeon, Francois Pierre, Michael, Steven, Picard, Michael H., Hung, Judy, Scherrer-Crosbie, Marielle, Zeng, Xin, Chaitman, Bernard R., Eckstein, Jane, Guruge, Bandula, Streif, Mary, Ali, Ziad, Genereux, Philippe, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Horst, Jennifer, Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Min, James, Arsanjani, Reza, Budoff, Matthew, Elmore, Kimberly, Gomez, Millie, Hague, Cameron, Hindoyan, Niree, Leipsic, Jonathan, Nakanishi, Rine, Srichai-Parsia, M. Barbara, Yeoh, Eunice, Youn, Tricia, Maggioni, Aldo P., Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Tricoli, Martinia, Carvalho, Antonio, Lopes, Renato, Barbosa, Lilian Mazza, Duarte, Tauane Bello, Soares, Tamara Colaiácovo, Aveiro Morata, Julia de, Carvalho, Pedro, Carvalho Maffei, Natalia de, Egydio, Flávia, Kawakami, Anelise, Oliveira, Janaina, Piloto, Elissa Restelli, Pozzibon, Jaqueline, Goodman, Shaun, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Jiang, Lixin, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Diaz, Rafael, Escobar, Claudia, Martin, Maria Eugenia, Pascual, Andrea, Lopez-Sendon, José, Moraga, Paloma, Hernandez, Victoria, Castro, Almudena, Posada, Maria, Fernandez, Sara, Villanueva, José Luis Narro, Selgas, Rafael, Steg, Gabriel, Abergel, Helene, Juliard, Jean Michel, White, Harvey, Alsweiler, Caroline, de Werf, Frans Van, Claes, Kathleen, Goetschalckx, Kaatje, Luyten, Ann, Robesyn, Valerie, Selvanayagam, Joseph B., Murphy, Deirdre, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, and Siddaram, Hemalata
- Published
- 2024
- Full Text
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3. Angiogenic Gene Therapy for Refractory Angina: Results of the EXACT Phase 2 Trial
- Author
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Nakamura, Kenta, Henry, Timothy D., Traverse, Jay H., Latter, David A., Mokadam, Nahush A., Answini, Geoffrey A., Williams, Adam R., Sun, Benjamin C., Burke, Christopher R., Bakaeen, Faisal G., DiCarli, Marcelo F., Chaitman, Bernard R., Peterson, Mark W., Byrnes, Dawn G., Ohman, E. Magnus, Pepine, Carl J., Crystal, Ronald G., Rosengart, Todd K., Kowalewski, Elaine, Koch, Gary G., Dittrich, Howard C., and Povsic, Thomas J.
- Published
- 2024
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4. Impact of Complete Revascularization in the ISCHEMIA Trial
- Author
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Boden, William, Harrington, Robert, Williams, David, Alexander, Karen P., Berger, Jeffrey, Mark, Daniel, Ballantyne, Christie, Beyar, Rafael, Bhargava, Balram, Buller, Chris, Carvalho, Antonio (Tony), Diaz, Rafael, Doerr, Rolf, Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Hachamovitch, Rory, Hamm, Christian, Held, Claes, Helm, Malte, Huber, Kurt, Jiang, Lixin, Keltai, Matyas, Kohsaka, Shun, Lang, Irene, Lopes, Renato, Lopez-Sendon, Jose, Maggioni, Aldo, Mancini, John, Bairey Merz, C. Noel, Min, James, Peterson, Eric, Ruzyllo, Witold, Selvanayagam, Joseph, Senior, Roxy, Sharir, Tali, Steg, Gabriel, Szwed, Hanna, Van de Werf, Frans, Weintraub, William, White, Harvey, Calfas, Karen, Champagne, Mary Ann, Davidson, Michael, Fleg, Jerome, McCullough, Peter A., Newman, Jonathan, Stone, Peter, Menasche, Philippe, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Blankenship, Jim, Brener, Sorin, Colombo, Antonio, de Bruyne, Bernard, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Mahaffey, Ken, Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Friedrich, Matthias, Kwong, Raymond, Oliver, Dana, Harrell, Frank, Blume, Jeffrey, Lee, Kerry, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Cohen, David, Bugiardini, Raffaele, Celutkiene, Jelena, Escobedo, Jorge, Hoye, Angela, Lyubarova, Radmila, Mattina, Deirdre, Peteiro, Jesus, Smanio, Paola, Berman, Dan, Leipsic, Jonathan, Mathew, Roy, Sidhu, Mandeep, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Gibson, C. Michael, Lamas, Gervasio, Deming, Nicole, Himmelfarb, Jonathan, Ouyang, Pamela, Woodard, Pamela, Nwosu, Samuel, Kirby, Ruth, Jeffries, Neal, Denaro, Jean E., Mavromichalis, Stephanie, Chan, Kevin, Cobb, Gia, Contreras, Aira, Cukali, Diana, Ferket, Stephanie, Gabriel, Andre, Hansen, Antonietta, Roberts, Arline, Naumova, Anna, Chang, Michelle, Islam, Sharder, Wayser, Graceanne, Yakubov, Solomon, Yee, Michelle, Callison, Caroline, Hogan, Isabelle, Qelaj, Albertina, Pirro, Charlotte, Van Loo, Kerrie, Wisniewski, Brianna, Gilsenan, Margaret, Lang, Bevin, Mohamed, Samaa, Esquenazi-Karonika, Shari, Mathews, Patenne, Setang, Vincent, Xavier, Mark, Bagai, Akshay, Broderick, Samuel, Crowder, Michelle, Cyr, Derek, Garg, Jyotsna, Gu, Xiangqiong, Hatch, Lisa, Heath, Anne, Huang, Zhen, Leimberger, Jeff, Marcus, Jill, Page, Courtney, Parker, Wanda, Pennachi, Wayne, Rockhold, Frank, Stevens, Susanna, Stone, Allegra, Thompson, Omar, Ussery, Sheri, White, Jennifer, Williams, Mary (Kaye), Xing, Weibing, Zhu, Songlin, Anstrom, Kevin, Baloch, Khaula, Blount, Janet, Cowper, Patricia, Davidson-Ray, Linda, Drew, Laura, Harding, Tina, Knight, J David, Minshall Liu, Diane, O’Neal, Betsy, Redick, Thomas, Jones, Philip, Nugent, Karen, Jingyan Wang, Grace, Phillips, Lawrence, Goyal, Abhinav, Hetrick, Holly, Hayes, Sean W., Friedman, John D., Gerlach, R. James, Hyun, Mark, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Kwong, Raymond Y., Mongeon, Francois Pierre, Michael, Steven, Hung, Judy, Scherrer-Crosbie, Marielle, Zeng, Xin, Eckstein, Jane, Guruge, Bandula, Streif, Mary, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Arsanjani, Reza, Budoff, Matthew, Elmore, Kimberly, Gomez, Millie, Hague, Cameron, Hindoyan, Niree, Mancini, GB John, Nakanishi, Rine, Srichai-Parsia, M. Barbara, Yeoh, Eunice, Youn, Tricia, Maggioni, Aldo P., Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Tricoli, Martinia, Carvalho, Antonio, Barbosa, Lilian Mazza, Bello Duarte, Tauane, Colaiácovo Soares, Tamara, de Aveiro Morata, Julia, Carvalho, Pedro, de Carvalho Maffei, Natalia, Egydio, Flávia, Kawakami, Anelise, Oliveira, Janaina, Restelli Piloto, Elissa, Pozzibon, Jaqueline, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Escobar, Claudia, Martin, Maria Eugenia, Pascual, Andrea, Lopez-Sendon, José, Moraga, Paloma, Hernandez, Victoria, Castro, Almudena, Posada, Maria, Fernandez, Sara, Narro Villanueva, José Luis, Selgas, Rafael, Abergel, Helene, Juliard, Jean Michel, Alsweiler, Caroline, Claes, Kathleen, Goetschalckx, Kaatje, Luyten, Ann, Robesyn, Valerie, Selvanayagam, Joseph B., Murphy, Deirdre, Garcevic, Nevena, Stojkovic, Jelena, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, Siddaram, Hemalata, Stone, Gregg W., Ali, Ziad A., O’Brien, Sean M., Rhodes, Grace, Genereux, Philippe, Bangalore, Sripal, Mavromatis, Kreton, Horst, Jennifer, Dressler, Ovidiu, Poh, Kian Keong, Nath, Ranjit K., Moorthy, Nagaraja, Witkowski, Adam, Dwivedi, Sudhanshu K., Bockeria, Olga, Chen, Jiyan, Smanio, Paola E.P., Picard, Michael H., Chaitman, Bernard R., Berman, Daniel S., Shaw, Leslee J., Boden, William E., White, Harvey D., Fremes, Stephen E., Rosenberg, Yves, Reynolds, Harmony R., Spertus, John A., Hochman, Judith S., and Maron, David J.
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- 2023
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5. Myocardial Infarction in the ISCHEMIA Trial
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Chaitman, Bernard R, Alexander, Karen P, Cyr, Derek D, Berger, Jeffrey S, Reynolds, Harmony R, Bangalore, Sripal, Boden, William E, Lopes, Renato D, Demkow, Marcin, Perna, Gian Piero, Riezebos, Robert K, McFalls, Edward O, Banerjee, Subhash, Bagai, Akshay, Gosselin, Gilbert, O’Brien, Sean M, Rockhold, Frank W, Waters, David D, Thygesen, Kristian A, Stone, Gregg W, White, Harvey D, Maron, David J, Hochman, Judith S, and Group, On behalf of the ISCHEMIA Research
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Clinical Trials and Supportive Activities ,Clinical Research ,Cost Effectiveness Research ,Heart Disease ,Cardiovascular ,Heart Disease - Coronary Heart Disease ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Coronary Artery Bypass ,Creatine Kinase ,MB Form ,Female ,Follow-Up Studies ,Humans ,Incidence ,Male ,Middle Aged ,Myocardial Infarction ,Myocardial Ischemia ,Percutaneous Coronary Intervention ,Prognosis ,Proportional Hazards Models ,Risk Factors ,Severity of Illness Index ,Survival Analysis ,catheterization ,drug therapy ,myocardial infarction ,myocardial ischemia ,myocardial revascularization ,ISCHEMIA Research Group ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
BackgroundIn the ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches), an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality in comparison with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular end points was myocardial infarction (MI).MethodsISCHEMIA prespecified that the primary and major secondary composite end points of the trial be analyzed using 2 MI definitions. For procedural MI, the primary MI definition used creatine kinase-MB as the preferred biomarker, whereas the secondary definition used cardiac troponin. Procedural thresholds were >5 times the upper reference level for percutaneous coronary intervention and >10 times for coronary artery bypass grafting. Procedural MI definitions included (1) a category of elevated biomarker only events with much higher biomarker thresholds, (2) new ST-segment depression of ≥1 mm for the primary and ≥0.5 mm for the secondary definition, and (3) new coronary dissections >National Heart, Lung, and Blood Institute grade 3. We compared MI type, frequency, and prognosis by treatment assignment using both MI definitions.ResultsProcedural MIs accounted for 20.1% of all MI events with the primary definition and 40.6% of all MI events with the secondary definition. Four-year MI rates in patients undergoing revascularization were more frequent with the invasive versus conservative strategy using the primary (2.7% versus 1.1%; adjusted hazard ratio [HR], 2.98 [95% CI, 1.87-4.73]) and secondary (8.2% versus 2.0%; adjusted HR, 5.04 [95% CI, 3.64-6.97]) MI definitions. Type 1 MIs were less frequent with the invasive versus conservative strategy using the primary (3.40% versus 6.89%; adjusted HR, 0.53 [95% CI, 0.41-0.69]; P
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- 2021
6. Rationale and design for the myocardial ischemia and transfusion (MINT) randomized clinical trial
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Carson, Jeffrey L., Ghafghazi, Shahab, Cooper, Howard A., Wood, Frances, Menegus, Mark, Uretsky, Barry, Vallurupalli, Srikanth, Maniatis, Gregory, Gruberg, Luis, Roswell, Robert, Rossi, Joseph, Abtahian, Farhad, Tessalee, Meechai, Barsness, Gregory, Abbott, J. Dawn, Aronow, Herbert, Ramanathan, Kodangudi, Schmidhofer, Mark, Keating, Friederike, Carson, Michael, Kontos, Michael, Qureshi, Mansoor, Clegg, Stacey, Laskey, Warren, Polonsky, Tamar, Gupta, Rajesh, Sheikh, Mujeeb Abdul, Uhl, Lynne, Mullen, Paul, Bracey, Arthur, Matthai, William, Stowell, Christopher, Dudzinski, David, Marhefka, Gregary, Weinstock, Perry, Lawson, William, Keller, Norma, Yuriditsky, Eugene, Thomas, Michael, Jacobs, Alice, Hochberg, Claudia, Siddiqi, Omar, Schulman-Marcus, Joshua, Torosoff, Mikhail, Gitter, Michael, Dai, Xuming, Traverse, Jay, McCamant, Eric, Scott, Jason, Swaminathan, Rajesh, Rao, Sunil, Goldsweig, Andrew M., DeFilippis, Andrew P., Salisbury, Adam, Landers, David, Raveendran, Ganesh, Ebrahimi, Ramin, Bach, Richard, Delehanty, Joseph, Shah, Raj C., Brener, Sorin, Doroshow, Jonathan, Caixeta, Adriano, Precoma, Dalton, Dall'Orto, Frederico Toledo Campo, De Andrade, Pedro Beraldo, Dracoulakis, Marianna, Maia, Lília Nigro, Ritt, Luiz Eduardo Fontelles, Quadros, Alexandre, Filho, Dário Celestino Sobral, De Martino, Fernando, Huynh, Thao, Schnell, Greg, Senaratne, Manohara, Tandon, Vikas, Neary, John, Laflamme, David, Dery, Jean-Pierre, Bainey, Kevin, Haichin, Richard, Dehghani, Payam, Quraishi, Ata Ur Rehman, Potter, Brian J., Carrier, François Martin, Goldfarb, Michael, Fordyce, Christopher, Sia, Ying Tung, Daneault, Benoit, Madan, Mina, McPherson, Terry, Ducas, John, Minhas, Kunal, Brass, Neil, Bagai, Akshay, Robinson, Simon, Džavík, Vladimír, Khan, Razi, Michaud, Nicolas, Steg, Gabriel, Ducrocq, Gregory, Puymirat, Etienne, Lemesle, Gilles, Ferrari, Emile, Lattuca, Benoit, Silvain, Johanne, Vanzetto, Gérald, Cetran, Laura, Lhermusier, Thibault, Cottin, Yves, Rosamel, Yann, Angoulvant, Denis, Dillinger, Jean Guillaume, Thuaire, Christophe, Popovic, Batric, Durand, Eric, Bouleti, Claire, Roubille, François, Delorme, Laurent, Crozier, Ian, Benatar, Jocelyne, Nandra, Samraj, Ternouth, Ian, Fisher, Nick, Brieger, David, Hillis, Graham, Brooks, Maria Mori, Chaitman, Bernard R., Alexander, John H., Goodman, Shaun G., Bertolet, Marnie, Rao, Sunil V., Triulzi, Darrell J., Fergusson, Dean A., Kostis, William J., Noveck, Helaine, Simon, Tabassome, Steg, Philippe Gabriel, Lopes, Renato D., White, Harvey, Alsweiler, Caroline, Morton, Erin, and Hébert, Paul C.
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- 2023
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7. Ischemia With Nonobstructive Coronary Arteries: Insights From the ISCHEMIA Trial
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Reynolds, Harmony R., Diaz, Ariel, Cyr, Derek D., Shaw, Leslee J., Mancini, G.B. John, Leipsic, Jonathon, Budoff, Matthew J., Min, James K., Hague, Cameron J., Berman, Daniel S., Chaitman, Bernard R., Picard, Michael H., Hayes, Sean W., Scherrer-Crosbie, Marielle, Kwong, Raymond Y., Lopes, Renato D., Senior, Roxy, Dwivedi, Sudhanshu K., Miller, Todd D., Chow, Benjamin J.W., de Silva, Ramesh, Stone, Gregg W., Boden, William E., Bangalore, Sripal, O’Brien, Sean M., Hochman, Judith S., and Maron, David J.
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- 2023
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8. Causes of cardiovascular and noncardiovascular death in the ISCHEMIA trial
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Sidhu, Mandeep S., Alexander, Karen P., Huang, Zhen, O'Brien, Sean M., Chaitman, Bernard R., Stone, Gregg W., Newman, Jonathan D., Boden, William E., Maggioni, Aldo P., Steg, Philippe Gabriel, Ferguson, Thomas B., Demkow, Marcin, Peteiro, Jesus, Wander, Gurpreet S., Phaneuf, Denis C., De Belder, Mark A., Doerr, Rolf, Alexanderson-Rosas, Erick, Polanczyk, Carisi A., Henriksen, Peter A., Conway, Dwayne S.G., Miro, Vicente, Sharir, Tali, Lopes, Renato D., Min, James K., Berman, Daniel S., Rockhold, Frank W., Balter, Stephen, Borrego, David, Rosenberg, Yves D., Bangalore, Sripal, Reynolds, Harmony R., Hochman, Judith S., and Maron, David J.
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- 2022
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9. Clinical events classification (CEC) in clinical trials: Report on the current landscape and future directions — proceedings from the CEC Summit 2018
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Sharma, Abhinav, Mahaffey, Kenneth W., Gibson, Charles Michael, Hicks, Karen A., Alexander, Karen P., Ali, Maria, Chaitman, Bernard R., Held, Claes, Hlatky, Mark, Jones, WIlliam Schuyler, Mehran, Roxana, Menon, Venu, Rockhold, Frank W., Seltzer, Jonathan, Spitzer, Ernest, Wilson, Matthew, and Lopes, Renato D.
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- 2022
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10. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia: A Target Trial Emulation Using MINT Trial Data.
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Portela, Gerard T., Carson, Jeffrey L., Swanson, Sonja A., Alexander, John H., Hébert, Paul C., Goodman, Shaun G., Steg, Philippe Gabriel, Bertolet, Marnie, Strom, Jordan B., Fergusson, Dean A., Simon, Tabassome, White, Harvey D., Cooper, Howard A., Abbott, J. Dawn, Rao, Sunil V., Chaitman, Bernard R., Fordyce, Christopher B., Lopes, Renato D., Daneault, Benoit, and Brooks, Maria M.
- Abstract
The optimal hemoglobin threshold to guide red blood cell transfusion for patients with acute myocardial infarction and anemia is uncertain. This prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial, which randomly assigned patients to a liberal transfusion threshold versus a more restrictive threshold, used target trial emulation methods to compare 4 transfusion strategies to maintain patients' hemoglobin concentrations at or above thresholds of 10, 9, 8, or 7 g/dL. Visual Abstract. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia: The optimal hemoglobin threshold to guide red blood cell transfusion for patients with acute myocardial infarction and anemia is uncertain. This prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial, which randomly assigned patients to a liberal transfusion threshold versus a more restrictive threshold, used target trial emulation methods to compare 4 transfusion strategies to maintain patients' hemoglobin concentrations at or above thresholds of 10, 9, 8, or 7 g/dL. Background: The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain. Objective: To estimate the efficacy of 4 individual hemoglobin thresholds (<10 g/dL [<100 g/L], <9 g/dL [<90 g/L], <8 g/dL [<80 g/L], and <7 g/dL [<70 g/L]) to guide transfusion in patients with acute MI and anemia. Design: Prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial using target trial emulation methods. (ClinicalTrials.gov: NCT02981407) Setting: 144 clinical sites in 6 countries. Participants: 3492 MINT trial participants with acute MI and a hemoglobin level below 10 g/dL. Intervention: Four transfusion strategies to maintain patients' hemoglobin concentrations at or above thresholds of 10, 9, 8, or 7 g/dL. Protocol exceptions were permitted for specified adverse clinical events. Measurements: Data from the MINT trial were leveraged to emulate 4 transfusion strategies and estimate per protocol effects on the composite outcome of 30-day death or recurrent MI (death/MI) and 30-day death using inverse probability weighting. Results: The 30-day risk for death/MI was 14.8% (95% CI, 11.8% to 18.4%) for a <10-g/dL strategy, 15.1% (CI, 11.7% to 18.2%) for a <9-g/dL strategy, 15.9% (CI, 12.4% to 19.0%) for a <8-g/dL strategy, and 18.3% (CI, 14.6% to 22.0%) for a <7-g/dL strategy. Absolute risk differences and risk ratios relative to the <10-g/dL strategy for 30-day death/MI increased as thresholds decreased, although 95% CIs were wide. Findings were similar and imprecise for 30-day death. Limitation: Unmeasured confounding may have persisted despite adjustment. Conclusion: The 30-day risks for death/MI and death among patients with acute MI and anemia seem to increase progressively with lower hemoglobin concentration thresholds for transfusion. However, the imprecision around estimates from this target trial analysis precludes definitive conclusions about individual hemoglobin thresholds. Primary Funding Source: National Heart, Lung, and Blood Institute. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial.
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Nurmohamed, Nick S, Min, James K, Anthopolos, Rebecca, Reynolds, Harmony R, Earls, James P, Crabtree, Tami, Mancini, G B John, Leipsic, Jonathon, Budoff, Matthew J, Hague, Cameron J, O'Brien, Sean M, Stone, Gregg W, Berger, Jeffrey S, Donnino, Robert, Sidhu, Mandeep S, Newman, Jonathan D, Boden, William E, Chaitman, Bernard R, Stone, Peter H, and Bangalore, Sripal
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MYOCARDIAL infarction ,CORONARY artery disease ,PROGNOSIS ,ATHEROSCLEROTIC plaque ,CORONARY disease - Abstract
Background and Aims The aim of this study was to determine the prognostic value of coronary computed tomography angiography (CCTA)–derived atherosclerotic plaque analysis in ISCHEMIA. Methods Atherosclerosis imaging quantitative computed tomography (AI-QCT) was performed on all available baseline CCTAs to quantify plaque volume, composition, and distribution. Multivariable Cox regression was used to examine the association between baseline risk factors (age, sex, smoking, diabetes, hypertension, ejection fraction, prior coronary disease, estimated glomerular filtration rate, and statin use), number of diseased vessels, atherosclerotic plaque characteristics determined by AI-QCT, and a composite primary outcome of cardiovascular death or myocardial infarction over a median follow-up of 3.3 (interquartile range 2.2–4.4) years. The predictive value of plaque quantification over risk factors was compared in an area under the curve (AUC) analysis. Results Analysable CCTA data were available from 3711 participants (mean age 64 years, 21% female, 79% multivessel coronary artery disease). Amongst the AI-QCT variables, total plaque volume was most strongly associated with the primary outcome (adjusted hazard ratio 1.56, 95% confidence interval 1.25–1.97 per interquartile range increase [559 mm
3 ]; P =.001). The addition of AI-QCT plaque quantification and characterization to baseline risk factors improved the model's predictive value for the primary outcome at 6 months (AUC 0.688 vs. 0.637; P =.006), at 2 years (AUC 0.660 vs. 0.617; P =.003), and at 4 years of follow-up (AUC 0.654 vs. 0.608; P =.002). The findings were similar for the other reported outcomes. Conclusions In ISCHEMIA, total plaque volume was associated with cardiovascular death or myocardial infarction. In this highly diseased, high-risk population, enhanced assessment of atherosclerotic burden using AI-QCT-derived measures of plaque volume and composition modestly improved event prediction. [ABSTRACT FROM AUTHOR]- Published
- 2024
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12. Predictors of Left Main Coronary Artery Disease in the ISCHEMIA Trial
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Senior, Roxy, Reynolds, Harmony R., Min, James K., Berman, Daniel S., Picard, Michael H., Chaitman, Bernard R., Shaw, Leslee J., Page, Courtney B., Govindan, Sajeev C., Lopez-Sendon, Jose, Peteiro, Jesus, Wander, Gurpreet S., Drozdz, Jaroslaw, Marin-Neto, Jose, Selvanayagam, Joseph B., Newman, Jonathan D., Thuaire, Christophe, Christopher, Johann, Jang, James J., Kwong, Raymond Y., Bangalore, Sripal, Stone, Gregg W., O’Brien, Sean M., Boden, William E., Maron, David J., and Hochman, Judith S.
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- 2022
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13. Comparative Prognostic Utility of Coronary CT and Invasive Angiography
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Leipsic, Jonathon, primary, Ben Zekry, Sagit, additional, Tzimas, Georgios, additional, Broderick, Samuel, additional, Mancini, G.B. John, additional, Hague, Cameron J., additional, Budoff, Matt J., additional, Rockhold, Frank W., additional, Chaitman, Bernard R., additional, Kirby, Ruth, additional, Stone, Gregg W., additional, Ali, Ziad A., additional, Min, James K., additional, Hochman, Judith S., additional, Maron, David J., additional, and Reynolds, Harmony R., additional
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- 2024
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14. Ultrasonic Texture Analysis for Acute Myocardial Infarction Risk Stratification: A Pilot Study
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Hathaway, Quincy A., primary, Jamthikar, Ankush D., additional, Chaitman, Bernard R., additional, Carson, Jeffery, additional, Yanamala, Naveena, additional, and Sengupta, Partho P., additional
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- 2024
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15. Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease : Insights From the ISCHEMIA Trial
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Reynolds, Harmony R., Cyr, Derek D., Bairey Merz, C. Noel, Shaw, Leslee J., Chaitman, Bernard R., Boden, William E., Alexander, Karen P., Rosenberg, Yves D., Bangalore, Sripal, Stone, Gregg W., Held, Claes, Spertus, John, Goetschalckx, Kaatje, Bockeria, Olga, Newman, Jonathan D., Berger, Jeffrey S., Elghamaz, Ahmed, Lopes, Renato D., Min, James K., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Harrington, Robert A., Thomas, Boban, O'Brien, Sean M., Maron, David J., Hochman, Judith S., Reynolds, Harmony R., Cyr, Derek D., Bairey Merz, C. Noel, Shaw, Leslee J., Chaitman, Bernard R., Boden, William E., Alexander, Karen P., Rosenberg, Yves D., Bangalore, Sripal, Stone, Gregg W., Held, Claes, Spertus, John, Goetschalckx, Kaatje, Bockeria, Olga, Newman, Jonathan D., Berger, Jeffrey S., Elghamaz, Ahmed, Lopes, Renato D., Min, James K., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Harrington, Robert A., Thomas, Boban, O'Brien, Sean M., Maron, David J., and Hochman, Judith S.
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Background Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline‐directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on stress testing, with and without invasive management. Methods and Results The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial randomized patients with moderate or severe ischemia to invasive management with angiography, revascularization, and guideline‐directed medical therapy, or initial conservative management with guideline‐directed medical therapy alone. We evaluated the primary outcome (cardiovascular death, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest) and other end points, by sex, in 1168 (22.6%) women and 4011 (77.4%) men. Invasive group catheterization rates were similar, with less revascularization among women (73.4% of invasive‐assigned women revascularized versus 81.2% of invasive‐assigned men; P<0.001). Women had less coronary artery disease: multivessel in 60.0% of invasive‐assigned women and 74.8% of invasive‐assigned men, and no ≥50% stenosis in 12.3% versus 4.5% (P<0.001). In the conservative group, 4‐year catheterization rates were 26.3% of women versus 25.6% of men (P=0.72). Guideline‐directed medical therapy use was lower among women with fewer risk factor goals attained. There were no sex differences in the primary outcome (adjusted hazard ratio [HR] for women versus men, 0.93 [95% CI, 0.77–1.13]; P=0.47) or the major secondary outcome of cardiovascular death/myocardial infarction (adjusted HR, 0.93 [95% CI, 0.76–1.14]; P=0.49), with no significant sex‐by‐treatment‐group interactions. Conclusions Women had less extensive coronary artery disease and, therefore, lower revascularization rates in the invasive group. Despite lower risk
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- 2024
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16. Abstract 12499: Anomalous Coronary Arteries Are Associated With Ischemia in the Ischemia Trial
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Jaspan, Vita, Leipsic, Jonathon A, Nemeth, Hayley, Mancini, G B, Budoff, Matthew, Hague, Cameron, Min, James, Shaw, Leslee J, Berman, Daniel, Picard, Michael, Chaitman, Bernard R, Kwong, Raymond Y, OBrien, Sean, Hochman, Judith S, Maron, David J, and Reynolds, Harmony
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- 2022
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17. Risk Prediction Tool for Assessing the Probability of Death or Myocardial Infarction in Patients With Stable Coronary Artery Disease
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Boden, William E., Hartigan, Pamela M., Mancini, John, Teo, Koon K., Chaitman, Bernard R., Maron, David J., Kostuk, William J., Hartigan, John A., Dada, Marcin, Spertus, John A., Bates, Eric R., and Weintraub, William S.
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- 2020
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18. Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial
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Reynolds, Harmony R., primary, Cyr, Derek D., additional, Merz, C. Noel Bairey, additional, Shaw, Leslee J., additional, Chaitman, Bernard R., additional, Boden, William E., additional, Alexander, Karen P., additional, Rosenberg, Yves D., additional, Bangalore, Sripal, additional, Stone, Gregg W., additional, Held, Claes, additional, Spertus, John, additional, Goetschalckx, Kaatje, additional, Bockeria, Olga, additional, Newman, Jonathan D., additional, Berger, Jeffrey S., additional, Elghamaz, Ahmed, additional, Lopes, Renato D., additional, Min, James K., additional, Berman, Daniel S., additional, Picard, Michael H., additional, Kwong, Raymond Y., additional, Harrington, Robert A., additional, Thomas, Boban, additional, O'Brien, Sean M., additional, Maron, David J., additional, Hochman, Judith S., additional, Mavromatis, Kreton, additional, Linefsky, Jason, additional, Miller, Todd, additional, Banerjee, Subhash, additional, Reynolds, Harmony R., additional, Donnino, Robert M., additional, Phillips, Lawrence M., additional, Saric, Muhamed, additional, Abdul‐Nour, Khaled, additional, Stone, Peter H., additional, Jang, James J., additional, Yee, Gennie, additional, Weitz, Steven, additional, Arnold, Suzanne, additional, O’Keefe, James Henry, additional, Shapiro, Michael D., additional, El‐Hajjar, Mohammad, additional, Sidhu, Mandeep S., additional, Fein, Steven A., additional, Torosoff, Mikhail T., additional, Lyubarova, Radmila, additional, Mookherjee, Sulagna, additional, Drzymalski, Krzysztof, additional, McFalls, Edward O., additional, Garcia, Santiago A., additional, Bertog, Stefan C., additional, Siddiqui, Rizwan A., additional, Ishani, Areef, additional, Hansen, Ronnell A., additional, Khouri, Michel Georges, additional, Goldberg, Jonathan L., additional, Goldweit, Richard, additional, Cohen, Ronny A., additional, Mirrer, Brooks, additional, Navarro, Victor, additional, Winchester, David E., additional, Kronenberg, Marvin, additional, Rogal, Philip, additional, McFarren, Christopher, additional, Heitner, John F., additional, Dauber, Ira M., additional, Cannan, Charles, additional, Sudarshan, Sriram, additional, Mehta, Puja K., additional, McDaniel, Michael, additional, Lerakis, Stamatios, additional, Quyyumi, Arshed, additional, Wenger, Nanette K., additional, Hedgepeth, Chester M., additional, Hurlburt, Heather, additional, Rosen, Alan, additional, Sahul, Zakir, additional, Booth, David, additional, Leung, Steve, additional, Abdel‐Latif, Ahmed, additional, Reda, Hassan, additional, Ziada, Khaled, additional, Setty, Sampoornima, additional, Barua, Rajat S., additional, Hage, Fadi, additional, Caldeira, Christiano, additional, Davies, James E., additional, Leesar, Massoud, additional, Heo, Jaekyeong, additional, Iskandrian, Amy, additional, Al Solaiman, Firas, additional, Singh, Satinder, additional, Dajani, Khaled, additional, Der Mesropian, Paul, additional, Sacco, Joseph, additional, McCandless, Brian, additional, Orgera, Marisa, additional, Arif, Imran, additional, Kerr, Hanan, additional, Trejo (Gutierrez), Jorge F., additional, Fletcher, Gerald, additional, Lane, Gary E., additional, Neeson, Lynn M., additional, Parikh, Pragnesh P., additional, Pollak, Peter M., additional, Shapiro, Brian P., additional, Landolfo, Kevin, additional, Gemignani, Anthony, additional, O’Rourke, Daniel, additional, Meadows, Judith L., additional, Call, Jason T., additional, Hannan, Joseph, additional, Bojar, Robert, additional, Kumar, Deepti, additional, Mukai, John, additional, Martin, Edward T., additional, Vorobiof, Gabriel, additional, Moorman, Alec, additional, Kinlay, Scott, additional, Hamburger, Robert J., additional, Rocco, Thomas P., additional, Bhatt, Deepak L., additional, Croce, Kevin, additional, Quin, Jacquelyn A., additional, Anumpa, Jati, additional, Zenati, Marco, additional, Faxon, David P., additional, Rayos, Glenn, additional, Seedhom, Ashraf, additional, Sullenberger, Lance, additional, Kumkumian, Gregory, additional, Sedlis, Steven P., additional, Donnino, Robert M., additional, Lorin, Jeffrey, additional, Tamis‐Holland, Jacqueline E., additional, Kornberg, Robert, additional, Leber, Robert, additional, Saba, Souheil, additional, Lee, Michael W., additional, Small, Delano R., additional, Nona, Wassim, additional, Alexander, Patrick B., additional, Rehman, Iram, additional, Badami, Umesh, additional, Marzo, Kevin, additional, Robbins, Inga H., additional, Levite, Howard A., additional, Shetty, Sanjay, additional, Patel, Mayuri, additional, Hamroff, Glenn S., additional, Little, Raymond W., additional, Zimbelman, Brandi D., additional, Lui, Charles Y., additional, Smith, Brigham R., additional, Vezina, Daniel P., additional, Khor, Lillian L., additional, Abraham, Josephine D., additional, Bull, David A., additional, McKellar, Stephen H., additional, Kotter, John, additional, Hu, Bob, additional, Labovitz, Arthur J., additional, Berlowitz, Michael, additional, Matar, Fadi, additional, Rodriguez, Fatima, additional, Schnittger, Ingela, additional, Fearon, William F., additional, Deedwania, Prakash, additional, Reddy, Kiran, additional, Sweeny, Joseph, additional, Spizzieri, Christopher, additional, Hochberg, Claudia P., additional, Salerno, William D., additional, Wyman, Ray, additional, Zarka, Amer, additional, Shah, Anil V., additional, Haldis, Thomas, additional, Kohn, Jeffrey A., additional, Girotra, Saket, additional, Almousalli, Omar, additional, Krishnam, Mayil S., additional, Milliken, Jeffrey C., additional, Patel, Pranav M., additional, Seto, Arnold H., additional, Harley, Kevin T., additional, Gibson, Michael A., additional, Allen, Byron J., additional, Coram, Rita, additional, Thomas, Sabu, additional, Schwartz, Ronald G., additional, Chen, Wei, additional, El Shahawy, Mahfouz, additional, Stafford, James, additional, Abernethy, William B., additional, Zurick, Andrew, additional, Meyer, Thomas M., additional, Morford, Ronald G., additional, Rutkin, Bruce, additional, Bokhari, Sabahat, additional, Sokol, Seth I., additional, Meisner, Jay, additional, Hamzeh, Ihab, additional, Misra, Arunima, additional, Wall, Matthew, additional, De Rosen, Veronica Lenges, additional, Alam, Mahboob, additional, Turner, Michael C., additional, Mulhearn, Thomas J., additional, Good, Arnold P., additional, Shammas, Nicolas W., additional, Chilton, Robert, additional, Nguyen, Patricia K., additional, Jezior, Matthew, additional, Gordon, Paul C., additional, Crain, Thomas, additional, Stenberg, Robert, additional, Pedalino, Ronald P., additional, Wiesel, Joseph, additional, Juang, George J., additional, Al‐Amoodi, Mohammed, additional, Wohns, David, additional, Lader, Ellis W., additional, Mumma, Michael, additional, Dharmarajan, Lekshmi, additional, McGarvey, Joseph F. X., additional, Downes, Thomas R., additional, Luckasen, Gary J., additional, Cheong, Benjamin, additional, Potluri, Srinivasa, additional, Mastouri, Ronald A., additional, Breall, Jeffery A., additional, Revtyak, George E., additional, Bazeley, Jonathan W., additional, Li, Dayuan, additional, Giedd, Kenneth, additional, Old, Wayne, additional, Burt, Francis, additional, Sokhon, Kozhaya, additional, Gopal, Deepika, additional, Valeti, Uma S., additional, Kobashigawa, Jon, additional, Govindan, Sajeev Chakanalil, additional, Nair, Rajesh Gopalan, additional, Manjunath, Cholenahally Nanjappa, additional, Moorthy, Nagaraja, additional, Manjunath, Satvic Cholenahally, additional, Narayanappa, Suryaprakash, additional, Pandit, Neeraj, additional, Nath, Ranjit Kumar, additional, Dwivedi, S. K., additional, Narain, V. S., additional, Chandra, Sharad, additional, Wander, Gurpreet S., additional, Tandon, Rohit, additional, Ralhan, Sarju, additional, Aslam, Naved, additional, Goyal, Abhishek, additional, Bhargava, Balram, additional, Karthikeyan, G., additional, Ramakrishnan, S., additional, Seth, Sandeep, additional, Yadav, Rakesh, additional, Singh, Sandeep, additional, Roy, Ambuj, additional, Parakh, Neeraj, additional, Verma, Sunil Kumar, additional, Narang, Rajiv, additional, Mishra, Sundeep, additional, Naik, Nitish, additional, Sharma, Gautam, additional, Choudhary, Shiv Kumar, additional, Patel, Chetan, additional, Gulati, Gurpreet, additional, Sharma, Sanjeev, additional, Bahl, V. K., additional, Mathew, Anoop, additional, Punnoose, Eapen, additional, Gadkari, Milind Avdhoot, additional, Gadage, Siddharth, additional, Pillay, Tapan Umesh, additional, Satheesh, Santhosh, additional, Mathur, Atul, additional, Kaul, Upendra, additional, Christopher, Johann, additional, Menon, Rajeev, additional, Kumar, Nirmal, additional, Oomman, Abraham, additional, Mao, Robert, additional, Solomon, Hilda, additional, Naik, Sudhir, additional, Khan, Sajeeda Parveen, additional, Grant, Purvez, additional, Kachru, Ranjan, additional, Ajit Kumar, V. K., additional, Ganapathi, Sanjay, additional, Jayakumar, K., additional, Sivadasanpillai, Harikrishnan, additional, Sasidharan, Bijulal, additional, Kapilamoorthy, T. R., additional, Polamuri, Praneeth, additional, Senior, Roxy, additional, Gurunathan, Sothinathan, additional, Karogiannis, Nikolaos, additional, Shah, Benoy N., additional, Trimlett, Richard HJ, additional, Rubens, Michael B., additional, Nicol, Edward D., additional, Mittal, Tarun K., additional, Hampson, Reinette, additional, Gamma, Reto Andreas, additional, de Belder, Mark A., additional, Thambyrajah, Jeet, additional, Nageh, Thuraia, additional, Davies, John R., additional, Lindsay, Steven J., additional, Kurian, John, additional, Jamil, Haqeel, additional, Raheem, Osama, additional, Hoye, Angela, additional, Donnelly, Patrick, additional, Valecka, Bernardas, additional, Chauhan, Anoop, additional, Barr, Craig, additional, Alfakih, Khaled, additional, Byrne, Jonathan, additional, Webb, Ian, additional, Henriksen, Peter, additional, OKane, Peter, additional, de Silva, Ramesh, additional, Conway, Dwayne S. G., additional, Sirker, Alexander A, additional, Hoole, Stephen P., additional, Witherow, Fraser N., additional, Johnston, Nicola, additional, Harbinson, Mark, additional, Walsh, Simon, additional, Douglas, Hanna, additional, Luckie, Matthew, additional, Sobolewska, Jolanta, additional, Jeetley, Paramjit, additional, Patel, Niket, additional, Kotecha, Tushar, additional, Travill, Christopher, additional, Karimullah, Iqbal, additional, Al‐Bustami, Mahmud, additional, Braganza, Denise, additional, Henderson, Robert, additional, Pointon, Kate, additional, Naik, Surendra, additional, Mathew, Thomas, additional, Berry, Colin, additional, Collison, Damien, additional, Roditi, Giles, additional, Moriarty, Andrew J., additional, Glover, Jason D., additional, Pradhan, Jiwan, additional, Mikhail, Ghada, additional, Francis, Darrel P., additional, Gosselin, Gilbert, additional, Diaz, Ariel, additional, Rheault, Philippe, additional, Barrero, Miguel, additional, Gagné, Carl‐Éric, additional, Pépin‐Dubois, Yanek, additional, Costa, Ricardo, additional, Sia, Ying Tung, additional, Lemay, Catherine, additional, Gisbert, Alejandro, additional, Gervais, Pierre, additional, Rheault, Alain, additional, Phaneuf, Denis Carl, additional, Garg, Pallav, additional, Chow, Benjamin J. W., additional, Hessian, Renee C., additional, Beanlands, Rob S., additional, Davies, Richard F., additional, Bainey, Kevin R., additional, Cheema, Asim N., additional, Bagai, Akshay, additional, Wald, Ron, additional, Goodman, Shaun, additional, Graham, John Joseph, additional, Peterson, Mark, additional, Chow, Chi‐Ming, additional, Abramson, Beth, additional, Cheema, Asim Nazir, additional, Vakani, Mohammad Tariq, additional, Cha, James, additional, Howarth, Andrew G, additional, Wong, Graham, additional, Uxa, Amar, additional, Galiwango, Paul, additional, Kassam, Saleem, additional, Mukherjee, Ashok, additional, Ricci, A. Joseph, additional, Lam, Andy, additional, Mehta, Shamir, additional, Udell, Jacob, additional, Généreux, Philippe, additional, Hameed, Adnan, additional, Daba, Ledjalem, additional, Hueb, Whady, additional, Rezende, Paulo Cury, additional, Silva, Expedito Eustáquio Ribeiro, additional, Hueb, Alexandre Ciappina, additional, Smanio, Paola Emanuela Poggio, additional, de Quadros, Alexandre Schaan, additional, Kalil, Renato Abdala Karam, additional, da Costa Vieira, José Luiz, additional, Grossmann, Gabriel, additional, de Oliveira, Pedro Píccaro, additional, Bridi, Leonardo, additional, Savaris, Simone, additional, Vitola, João V., additional, Cerci, Rodrigo J., additional, Farias, Fabio R., additional, Fernandes, Miguel M., additional, Marin‐Neto, José Antonio, additional, Schmidt, André, additional, de Oliveira Lima Filho, Moysés, additional, Oliveira, Ricardo Mendes, additional, Chierice, João Reynaldo Abbud, additional, Polanczyk, Carísi A., additional, Furtado, Mariana V., additional, Smidt, Luis F., additional, Carvalho, Antonio Carlos, additional, Pucci, Gustavo, additional, Lyra, Flavio, additional, Junior, Alvaro Rabelo Alves, additional, Dracoulakis, Marianna D. A., additional, Lima, Rodolfo G. S. D, additional, Figueiredo, Estevao, additional, Caramori, Paulo Ricardo, additional, Tumelero, Rogerio, additional, Dall’Orto, Frederico, additional, Mesquita, Claudio T., additional, Colafranseschi, Alexandre S., additional, Oliveira, Amarino C., additional, Carvalho, Luiz A., additional, Palazzo, Isabella C., additional, Sousa, Andre S., additional, da Silva, Expedito Eustáquio Ribeiro, additional, de Barros, Pedro Gabriel Melo, additional, de Pádua Silva Baptista, Luciana, additional, Rodrigues, Marcelo Jamus, additional, de Resende, Marcos Valério Coimbra, additional, Saraiva, Jose Francisco, additional, Costantini, Costantino, additional, Demkow, Marcin, additional, Pracon, Radoslaw, additional, Kepka, Cezary, additional, Teresinska, Anna, additional, Kryczka, Karolina, additional, Henzel, Jan, additional, Solecki, Mateusz, additional, Kaczmarska, Edyta, additional, Mazurek, Tomasz, additional, Drozdz, Jaroslaw, additional, Czarniak, Bartosz, additional, Frach, Malgorzata, additional, Szymczyk, Konrad, additional, Niedzwiecka, Iwona, additional, Sobczak, Sebastian, additional, Ciurus, Tomasz, additional, Jakubowski, Piotr, additional, Misztal‐Teodorczyk, Magdalena, additional, Teodorczyk, Dawid, additional, Fratczak, Aleksandra, additional, Szkopiak, Marcin, additional, Lebioda, Patrycja, additional, Wlodarczyk, Michal, additional, Plachcinska, Anna, additional, Kusmierek, Jacek, additional, Miller, Magdalena, additional, Marciniak, Halina, additional, Wojtczak‐Soska, Karolina, additional, Luczak, Katarzyna, additional, Tarchalski, Tomasz, additional, Cichocka‐Radwan, Anna, additional, Szwed, Hanna, additional, Szulczyk, Grazyna Anna, additional, Witkowski, Adam, additional, Kukula, Krzysztof, additional, Celinska‐Spodar, Malgorzta, additional, Zalewska, Joanna, additional, Gajos, Grzegorz, additional, Bury, Krzysztof, additional, Pruszczyk, Piotr, additional, Roik, Marek, additional, Loboz‐Grudzien, Krystyna, additional, Sokalski, Leszek, additional, Brzezinska, Barbara, additional, Lesiak, Maciej, additional, Lanocha, Magdalena, additional, Reczuch, Krzysztof W., additional, Kalarus, Zbigniew, additional, Swiatkowski, Andrzej, additional, Szulik, Mariola, additional, Musial, Wlodzimierz J., additional, Bockeria, Leo, additional, Petrosyan, Karen, additional, Trifonova, Tatiana, additional, Chernyavskiy, Alexander M., additional, Kretov, Evgeniy I., additional, Grazhdankin, Igor O., additional, Bershtein, Leonid L., additional, Sayganov, Sergey A., additional, Kuzmina‐Krutetskaya, Anastasia M., additional, Zbyshevskaya, Elizaveta V., additional, Katamadze, Nana O., additional, Demchenko, Elena A., additional, Kozlov, Pavel S., additional, Kozulin, Vikentiy Y., additional, Lubinskaya, Ekaterina I., additional, Lopez‐Sendon, Jose, additional, Castro, Almudena, additional, Salicio, Elena Refoyo, additional, Guzman, Gabriela, additional, Galeote, Gabriel, additional, Valbuena, Silvia, additional, Peteiro, Jesús, additional, Martínez‐Ruíz, María Dolores, additional, Pérez‐Fernández, Ruth, additional, Cuenca‐Castillo, José J., additional, Flores‐Ríos, Xacobe, additional, Prada‐Delgado, Óscar, additional, Barge‐Caballero, Gonzalo, additional, Juanatey, Jose Ramon Gonzalez, additional, Bayarri, Miguel Souto, additional, Nuñez, Virginia Pubull, additional, Sanchez, Raymundo Ocaranza, additional, Alvarez, Belen Cid, additional, Gil, Carlos Peña, additional, Monzonis, Amparo Martinez, additional, Sionis, Alessandro, additional, Perales, Montserrat Vila, additional, Padró, Josep Maria, additional, Peñaranda, Antonio Serra, additional, Picart, Joan García, additional, Iglesias, Antonino Ginel, additional, Marimon, Xavier Garcia‐Moll, additional, Lladó, Guillem Pons, additional, Costa, Francesc Carreras, additional, Miro, Vicente, additional, Diez, Jose L., additional, Calvillo, Pilar, additional, Ortuño, F. Marin, additional, Chávarri, M. Valdés, additional, Montolliu, A. Tello, additional, Bermudez, E. Pinar, additional, De La Morena, G., additional, Blancas, Montserrat Gracida, additional, Luena, Jose Enrique Castillo, additional, Fernandez‐Aviles, Francisco, additional, Chen, Jiyan, additional, Wu, Yongjian, additional, Ma, Yitong, additional, Yang, Yining, additional, Ji, Zheng, additional, Yang, Xinchun, additional, Lin, Wenhua, additional, Zeng, Hesong, additional, Fu, Xin, additional, Yang, Bin, additional, Wang, Songtao, additional, Cheng, Gong, additional, Zhao, Yulan, additional, Fang, Xuehua, additional, Zeng, Qiutang, additional, Su, Xi, additional, Li, Qingxian, additional, Nie, Shao‐ping, additional, Yu, Qin, additional, Wang, Jian’an, additional, Zhang, Shuyang, additional, Liu, Zhenyu, additional, Perna, Gian Piero, additional, Marini, Marco, additional, Gabrielli, Gabriele, additional, Provasoli, Stefano, additional, Verna, Edoardo, additional, Monti, Lorenzo, additional, Nardi, Barbara, additional, Di Chiara, Antonio, additional, Mortara, Andrea, additional, Galvani, Marcello, additional, Ottani, Filippo, additional, Sicuro, Marco, additional, Calabro, Paolo, additional, Formisano, Tiziana, additional, Tarantini, Giuseppe, additional, Cucchini, Umberto, additional, Andres, Anto Luigi, additional, Racca, Emanuela, additional, Briguori, Carlo, additional, Amati, Roberto, additional, Vergoni, William, additional, Russo, Aldo, additional, Fanelli, Raffaele, additional, Poh, Kian‐Keong, additional, Chai, Ping, additional, Lau, Titus, additional, Loh, Joshua P., additional, Tay, Edgar L., additional, Teoh, Kristine, additional, Teo, Lynette L., additional, Ong, Ching‐Ching, additional, Wong, Raymond C., additional, Loh, Poay‐Huan, additional, Kofidis, Theodoros, additional, Chan, Wan Xian, additional, Chan, Koo Hui, additional, Foo, David, additional, Kong, Jason Loh Kwok, additional, Er, Ching Min, additional, Jafary, Fahim Haider, additional, Chua, Terrance, additional, Doerr, Rolf, additional, Stumpf, Juergen, additional, Matschke, Klaus, additional, Simonis, Gregor, additional, Kadalie, Clemens T., additional, Sechtem, Udo, additional, Ong, Peter, additional, Schulze, P. Christian, additional, Goebel, Bjoern, additional, Lenk, Karsten, additional, Nickenig, Georg, additional, Schuchlenz, Herwig, additional, Weikl, Stefan, additional, Lang, Irene Marthe, additional, Huber, Kurt, additional, Jakl‐Kotauschek, Gabriele, additional, Vertes, Andras, additional, Varga, Albert, additional, Fontos, Geza, additional, Merkely, Bela, additional, Kerecsen, Gabor, additional, Hinic, Sasa, additional, Zdravkovic, Marija, additional, Mudrenovic, Vladan, additional, Crnokrak, Bogdan, additional, Beleslin, Branko D., additional, Boskovic, Nikola N., additional, Petrovic, Marija T., additional, Dobric, Milan R., additional, Markovic, Zeljko Z., additional, Mladenovic, Ana S., additional, Cemerlic‐Adjic, Nada, additional, Davidovic, Goran, additional, Vucic, Rada, additional, Dekleva, Milica Nikola, additional, Stankovic, Goran, additional, Apostolovic, Svetlana, additional, Escobedo, Jorge, additional, Baleón‐Espinosa, Rubén, additional, Campos‐Santaolalla, Arturo S., additional, Durán‐Cortés, Elihú, additional, Flores‐Palacios, José M., additional, García‐Rincón, Andrés, additional, Jiménez‐Santos, Moisés, additional, Peñafiel, Joaquín V., additional, Ortega‐Ramírez, José A., additional, Valdespino‐Estrada, Aquiles, additional, Rosas, Erick Alexánderson, additional, Selvanayagam, Joseph B., additional, Joseph, Majo X., additional, Thambar, Suku T., additional, Beltrame, John F., additional, Hillis, Graham S., additional, Thuaire, Christophe, additional, Dutoiu, Téodora, additional, Steg, Philippe Gabriel, additional, Juliard, Jean‐Michel, additional, Slama, Michel S., additional, El Mahmoud, Rami, additional, Nicollet, Eric, additional, Goube, Pascal, additional, Barone‐Rochette, Gilles, additional, Furber, Alain, additional, Bière, Loïc, additional, Laucevicius, Aleksandras, additional, Celutkiene, Jelena, additional, Kedhi, Elvin, additional, Timmer, Jorik, additional, Hermanides, Rik, additional, Kaplan, Eliza, additional, Riezebos, Robert K., additional, Samadi, Pouneh, additional, van Dongen, Elise, additional, Niehe, Sander R., additional, Suryapranata, Harry, additional, van Vugt, Stijn, additional, Ramos, Ruben, additional, Cacela, Duarte, additional, Santana, Ana, additional, Fiarresga, Antonio, additional, Sousa, Lidia, additional, Marques, Hugo, additional, Patricio, Lino, additional, Bernanrdes, Luis, additional, Rio, Pedro, additional, Carvalho, Ramiro, additional, Ferreira, Rui, additional, Silva, Tiago, additional, Rodrigues, Ines, additional, Modas, Pedro, additional, Portugal, Guilherme, additional, Fragata, Jose, additional, Pinto, Fausto J., additional, Menezes, Miguel Nobre, additional, Lopes, Guilhermina Cantinho, additional, Almeida, Ana Gomes, additional, Silva, Pedro Canas, additional, Nobre, Angelo, additional, Francisco, Ana Rita, additional, Ferreira, Nuno, additional, Lopes, Ricardo L., additional, Guzman, Luis, additional, Figal, Julio César, additional, Méndiz, Oscar, additional, Cortés, Claudia, additional, Favaloro, Roberto René, additional, Alvarez, Carlos, additional, Courtis, Javier, additional, Zeballos, Gabriela, additional, Schiavi, Lilia, additional, Rubio, Mariano, additional, Devlin, Gerard Patrick, additional, Fisher, Raewyn, additional, Stewart, Ralph Alan Huston, additional, White, Harvey Douglas, additional, Benatar, Jocelyne, additional, Kedev, Sasko, additional, Mitevska, Irena Peovska, additional, Kostovska, Elizabeta Srbinovska, additional, Pejkov, Hristo, additional, Eggers, Kai, additional, Frostfelt, Gunnar, additional, Johnston, Nina, additional, Olsowka, Maciej, additional, Åkerblom, Axel, additional, Soveri, Inga, additional, Aspberg, Johannes, additional, Sharir, Tali, additional, Elian, Dan, additional, Kerner, Arthur, additional, Massalha, Samia, additional, Fukuda, Keiichi, additional, Kohsaka, Shun, additional, Yasuda, Satoshi, additional, Nishimura, Shigeyuki, additional, Van de Werf, Frans, additional, Claes, Kathleen, additional, Hung, Chung‐Lieh, additional, Yun, Chun‐Ho, additional, Hou, Charles Jia‐Yin, additional, Kuo, Jen‐Yuan, additional, Yeh, Hung‐I, additional, Hung, Ta‐Chuan, additional, Li, Jiun‐Yi, additional, Chien, Chen‐Yen, additional, Tsai, Cheng‐Ting, additional, Liu, Chun‐Chieh, additional, Yu, Fa‐Chang, additional, Lin, Yueh‐Hung, additional, Lan, Wei‐Ren, additional, Yen, Chih‐Hsuan, additional, Tsai, Jui‐Peng, additional, Sung, Kuo‐Tzu, additional, Ntsekhe, Mpiko, additional, Pandie, Shaheen, additional, Viljoen, Charle A., additional, De Andrade, Marianne, additional, Moccetti, Tiziano, additional, Rossi, M. Grazia, additional, Abdelhamid, Magdy, additional, Adel, Ahmed, additional, Kamal, Ahmed, additional, Mahrous, Hossam, additional, El Kaffas, Sameh, additional, El Fishawy, Hussien, additional, Pop, Calin, additional, Claudia, Matei, additional, Popescu, Bogdan A., additional, Ginghina, Carmen, additional, Deleanu, Dan, additional, Iliescu, Vlad A., additional, Al‐Mallah, Mouaz H., additional, Aljzeeri, Ahmed, additional, Najm, Hani, additional, Alghamdi, Ali, additional, Ramos, Walter Enrique Mogrovejo, additional, Kuanprasert, Srun, additional, Prommintikul, Arintaya, additional, Nawarawong, Weerachai, additional, Woragidpoonpol, Surin, additional, Tepsuwan, Thitipong, additional, Taksaudom, Noppon, additional, Rimsukcharoenchai, Chataroon, additional, Euathrongchit, Juntima, additional, Wannasopha, Yutthaphan, additional, Yamwong, Sukit, additional, Sritara, Piyamitr, additional, Aramcharoen, Suthara, additional, Meemuk, Krissada, additional, Khairuddin, Ahmad, additional, Hadi, Hafidz Abd, additional, and Yahaya, Shaiful Azmi, additional
- Published
- 2024
- Full Text
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19. Outcomes of Participants with Diabetes in the ISCHEMIA Trials
- Author
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Newman, Jonathan D., Anthopolos, Rebecca, Mancini, G.B. John, Bangalore, Sripal, Reynolds, Harmony R., Kunichoff, Dennis F., Senior, Roxy, Peteiro, Jesus, Bhargava, Balram, Garg, Pallav, Escobedo, Jorge, Doerr, Rolf, Mazurek, Tomasz, Gonzalez-Juanatey, Jose, Gajos, Grzegorz, Briguori, Carlo, Cheng, Hong, Vertes, Andras, Mahajan, Sandeep, Guzman, Luis A., Keltai, Matyas, Maggioni, Aldo P., Stone, Gregg W., Berger, Jeffrey S., Rosenberg, Yves D., Boden, William E., Chaitman, Bernard R., Fleg, Jerome L., Hochman, Judith S., and Maron, David J.
- Published
- 2021
- Full Text
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20. Impact of Chronic Kidney Disease on Outcomes of Myocardial Revascularization in Patients With Diabetes
- Author
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Farkouh, Michael E., Sidhu, Mandeep S., Brooks, Maria M., Vlachos, Helen, Boden, William E., Frye, Robert L., Hartigan, Pamela, Siami, F.S., Bittner, Vera A., Chaitman, Bernard R., Mancini, G.B. John, and Fuster, Valentin
- Published
- 2019
- Full Text
- View/download PDF
21. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia
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Carson, Jeffrey L., primary, Brooks, Maria Mori, additional, Hébert, Paul C., additional, Goodman, Shaun G., additional, Bertolet, Marnie, additional, Glynn, Simone A., additional, Chaitman, Bernard R., additional, Simon, Tabassome, additional, Lopes, Renato D., additional, Goldsweig, Andrew M., additional, DeFilippis, Andrew P., additional, Abbott, J. Dawn, additional, Potter, Brian J., additional, Carrier, Francois Martin, additional, Rao, Sunil V., additional, Cooper, Howard A., additional, Ghafghazi, Shahab, additional, Fergusson, Dean A., additional, Kostis, William J., additional, Noveck, Helaine, additional, Kim, Sarang, additional, Tessalee, Meechai, additional, Ducrocq, Gregory, additional, Gabriel Melo de Barros e Silva, Pedro, additional, Triulzi, Darrell J., additional, Alsweiler, Caroline, additional, Menegus, Mark A., additional, Neary, John D., additional, Uhl, Lynn, additional, Strom, Jordan B., additional, Fordyce, Christopher B., additional, Ferrari, Emile, additional, Silvain, Johanne, additional, Wood, Frances O., additional, Daneault, Benoit, additional, Polonsky, Tamar S., additional, Senaratne, Manohara, additional, Puymirat, Etienne, additional, Bouleti, Claire, additional, Lattuca, Benoit, additional, White, Harvey D., additional, Kelsey, Sheryl F., additional, Steg, P. Gabriel, additional, and Alexander, John H., additional
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- 2023
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22. Fourth Universal Definition of Myocardial Infarction (2018)
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Thygesen, Kristian, Alpert, Joseph S., Jaffe, Allan S., Chaitman, Bernard R., Bax, Jeroen J., Morrow, David A., and White, Harvey D.
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- 2018
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23. Impact of treatment strategies on outcomes in patients with stable coronary artery disease and type 2 diabetes mellitus according to presenting angina severity: A pooled analysis of three federally-funded randomized trials
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Mancini, G.B. John, Boden, William E., Brooks, Maria M., Vlachos, Helen, Chaitman, Bernard R., Frye, Robert, Bittner, Vera, Hartigan, Pamela M., and Dagenais, Gilles R.
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- 2018
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24. Thiazolidinediones and Risk of Atrial Fibrillation Among Patients with Diabetes and Coronary Disease
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Pallisgaard, Jannik Langtved, Brooks, Maria Mori, Chaitman, Bernard R., Boothroyd, Derek B., Perez, Marco, and Hlatky, Mark A.
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- 2018
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25. 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials
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Fitter, Heather D., Illoh, Kachikwu, Cavanaugh, Kenneth J., Jr., Scirica, Benjamin M., Irony, Ilan, Brown Kichline, Rachel E., Levine, Jonathan G., Park, Anna, Sacks, Leonard, Szarfman, Ana, Unger, Ellis F., Wachter, Lori Ann, Zuckerman, Bram, Mitchel, Yale, Peddicord, Douglas, Shook, Thomas, Kisler, Bron, Jaffe, Charles, Bartley, Rhonda, DeMets, David L., Mencini, MariJo, Janning, Cheri, Bai, Steve, Lawrence, John, D’Agostino, Ralph B., Sr., Pocock, Stuart J., Hicks, Karen A., Mahaffey, Kenneth W., Mehran, Roxana, Nissen, Steven E., Wiviott, Stephen D., Dunn, Billy, Solomon, Scott D., Marler, John R., Teerlink, John R., Farb, Andrew, Morrow, David A., Targum, Shari L., Sila, Cathy A., Thanh Hai, Mary T., Jaff, Michael R., Joffe, Hylton V., Cutlip, Donald E., Desai, Akshay S., Lewis, Eldrin F., Gibson, C. Michael, Landray, Martin J., Lincoff, A. Michael, White, Christopher J., Brooks, Steven S., Rosenfield, Kenneth, Domanski, Michael J., Lansky, Alexandra J., McMurray, John J.V., Tcheng, James E., Steinhubl, Steven R., Burton, Paul, Mauri, Laura, O’Connor, Christopher M., Pfeffer, Marc A., Hung, H.M. James, Stockbridge, Norman L., Chaitman, Bernard R., and Temple, Robert J.
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- 2018
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26. The QT interval and risk of incident atrial fibrillation
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Mandyam, Mala C, Soliman, Elsayed Z, Alonso, Alvaro, Dewland, Thomas A, Heckbert, Susan R, Vittinghoff, Eric, Cummings, Steven R, Ellinor, Patrick T, Chaitman, Bernard R, Stocke, Karen, Applegate, William B, Arking, Dan E, Butler, Javed, Loehr, Laura R, Magnani, Jared W, Murphy, Rachel A, Satterfield, Suzanne, Newman, Anne B, and Marcus, Gregory M
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Heart Disease ,Cardiovascular ,Aging ,Clinical Research ,Good Health and Well Being ,Aged ,Atrial Fibrillation ,Cohort Studies ,Electrocardiography ,Female ,Humans ,Incidence ,Long QT Syndrome ,Male ,Middle Aged ,Risk Factors ,Atrial fibrillation ,Epidemiology ,Risk ,QT interval ,Electrocardiogram ,ECG ,AF ,ARIC ,Atherosclerosis Risk in Communities ,CHF ,CHS ,CI ,Cardiovascular Health Study ,HR ,HTN ,Health ABC ,Health ,Aging ,and Body Composition ,LQTS ,QT corrected by using the Framingham formula ,QT(Fram) ,QTc ,REGARDS ,Reasons for Geographic and Racial Differences in Stroke ,atrial fibrillation ,confidence interval ,congestive heart failure ,corrected QT interval ,electrocardiogram ,hazard ratio ,hypertension ,long QT syndrome ,Biomedical Engineering ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundAbnormal atrial repolarization is important in the development of atrial fibrillation (AF), but no direct measurement is available in clinical medicine.ObjectiveTo determine whether the QT interval, a marker of ventricular repolarization, could be used to predict incident AF.MethodsWe examined a prolonged QT interval corrected by using the Framingham formula (QT(Fram)) as a predictor of incident AF in the Atherosclerosis Risk in Communities (ARIC) study. The Cardiovascular Health Study (CHS) and Health, Aging, and Body Composition (ABC) study were used for validation. Secondary predictors included QT duration as a continuous variable, a short QT interval, and QT intervals corrected by using other formulas.ResultsAmong 14,538 ARIC study participants, a prolonged QT(Fram) predicted a roughly 2-fold increased risk of AF (hazard ratio [HR] 2.05; 95% confidence interval [CI] 1.42-2.96; P < .001). No substantive attenuation was observed after adjustment for age, race, sex, study center, body mass index, hypertension, diabetes, coronary disease, and heart failure. The findings were validated in Cardiovascular Health Study and Health, Aging, and Body Composition study and were similar across various QT correction methods. Also in the ARIC study, each 10-ms increase in QT(Fram) was associated with an increased unadjusted (HR 1.14; 95% CI 1.10-1.17; P < .001) and adjusted (HR 1.11; 95% CI 1.07-1.14; P < .001) risk of AF. Findings regarding a short QT interval were inconsistent across cohorts.ConclusionsA prolonged QT interval is associated with an increased risk of incident AF.
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- 2013
27. Ischemia Severity, Coronary Artery Disease Extent, and Exercise Capacity in ISCHEMIA.
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Fleg, Jerome L., Huang, Zhen, Reynolds, Harmony R., Shaw, Leslee J., Chaitman, Bernard R., O'Brien, Sean M., Berstein, Leonid, Peteiro, Jesus, Smanio, Paola E.P., Wander, Gurpreet S., Berger, Jeffrey S., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Min, James K., Phillips, Lawrence M., Bangalore, Sripal, Maron, David J., and Hochman, Judith S.
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- 2024
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28. LB-2 | VEGF Gene Therapy Improves Exercise Time, Ischemia, and Symptoms in Patients with Refractory Angina: Results of the Phase II EXACT Trial
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Nakamura, Kenta, Henry, Timothy D., Traverse, Jay H., Latter, David A., Mokadam, Nahush A., Answini, Geoffrey A., Williams, Adam R., Sun, Benjamin, Burke, Christopher R., Bakaeen, Faisal G., DiCarli, Marcelo F., Chaitman, Bernard R., Peterson, Mark W., Byrnes, Dawn G., Ohman, E.M., Pepine, Carl J., Crystal, Ronald G., Rosengart, Todd K., Kowalewski, Elaine, Koch, Gary G., Dittrich, Howard C., and Povsic, Thomas Joseph
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- 2024
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29. Abstract 13030: Causes of Cardiovascular and Non-cardiovascular Mortality in the Ischemia Trial
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Sidhu, Mandeep S, Alexander, Karen P, Huang, Zhen, O’Brien, Sean M, Chaitman, Bernard R, Stone, Gregg W, Newman, Jonathan D, Boden, William E, Maggioni, Aldo P, Steg, Philippe Gabriel, Ferguson, T Bruce, Demkow, Marcin, Peteiro, Jesus, Wander, Gurpreet S, de Belder, Mark A, Szwed, Hanna, Doerr, Rolf, Alexanderson, Erick, Polanczyk, Carisi, Henriksen, Peter, Conway, Dwayne, Miro, Vicente, Sharir, Tali, Rosenberg, Yves D, Bangalore, Sripal, Reynolds, Harmony R, Hochman, Judith S, and Maron, David J
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- 2020
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30. Exercise Testing
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Laddu, Abhay Atul, Alderson, Lisa, Chaitman, Bernard R., Willerson, James T., Series editor, and Holmes, Jr., David R., editor
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- 2015
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31. Effect of Coronary Anatomy and Myocardial Ischemia on Long-Term Survival in Patients with Stable Ischemic Heart Disease
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Weintraub, William S., Hartigan, Pamela M., Mancini, G.B. John, Teo, Koon K., Maron, David J., Spertus, John A., Chaitman, Bernard R., Shaw, Leslee J., Berman, Daniel, and Boden, William E.
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- 2019
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32. Survival After Invasive or Conservative Management of Stable Coronary Disease
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Hochman, Judith S., primary, Anthopolos, Rebecca, additional, Reynolds, Harmony R., additional, Bangalore, Sripal, additional, Xu, Yifan, additional, O’Brien, Sean M., additional, Mavromichalis, Stavroula, additional, Chang, Michelle, additional, Contreras, Aira, additional, Rosenberg, Yves, additional, Kirby, Ruth, additional, Bhargava, Balram, additional, Senior, Roxy, additional, Banfield, Ann, additional, Goodman, Shaun G., additional, Lopes, Renato D., additional, Pracoń, Radosław, additional, López-Sendón, José, additional, Maggioni, Aldo Pietro, additional, Newman, Jonathan D., additional, Berger, Jeffrey S., additional, Sidhu, Mandeep S., additional, White, Harvey D., additional, Troxel, Andrea B., additional, Harrington, Robert A., additional, Boden, William E., additional, Stone, Gregg W., additional, Mark, Daniel B., additional, Spertus, John A., additional, Maron, David J., additional, Hochman, Judith S., additional, Esquenazi-Karonika, Shari, additional, Gilsenan, Margaret, additional, Gwiszcz, Ewelina, additional, Mathews, Patenne, additional, Mohamed, Samaa, additional, Naumova, Anna, additional, Roberts, Arline, additional, VanLoo, Kerrie, additional, Lu, Ying, additional, Huang, Zhen, additional, Broderick, Samuel, additional, Guzmán, Luis, additional, Selvanayagam, Joseph, additional, Steg, Gabriel, additional, Juliard, Jean-Michel, additional, Doerr, Rolf, additional, Keltai, Matyas, additional, Thomas, Boban, additional, Sharir, Tali, additional, Nikolsky, Eugenia, additional, Maggioni, Aldo P., additional, Kohsaka, Shun, additional, Escobedo, Jorge, additional, Bockeria, Olga, additional, Held, Claes, additional, Shaw, Leslee J., additional, Phillips, Lawrence, additional, Berman, Daniel, additional, Kwong, Raymond Y., additional, Picard, Michael H., additional, Chaitman, Bernard R., additional, Ali, Ziad, additional, Min, James, additional, Mancini, G.B. John, additional, Leipsic, Jonathon, additional, Hillis, Graham, additional, Thambar, Suku, additional, Joseph, Majo, additional, Beltrame, John, additional, Lang, Irene, additional, Schuchlenz, Herwig, additional, Huber, Kurt, additional, Goetschalckx, Kaatje, additional, Hueb, Whady, additional, Caramori, Paulo Ricardo, additional, de Quadros, Alexandre, additional, Smanio, Paola, additional, Mesquita, Claudio, additional, Vitola, João, additional, Marin-Neto, José, additional, da Silva, Expedito Ribeiro, additional, Tumelero, Rogério, additional, Andrade, Marianna, additional, Alves, Alvaro Rabelo, additional, Dall’Orto, Frederico, additional, Polanczyk, Carisi, additional, Figueiredo, Estevão, additional, Howarth, Andrew, additional, Gosselin, Gilbert, additional, Cheema, Asim, additional, Bainey, Kevin, additional, Phaneuf, Denis, additional, Diaz, Ariel, additional, Garg, Pallav, additional, Mehta, Shamir, additional, Wong, Graham, additional, Lam, Andy, additional, Cha, James, additional, Galiwango, Paul, additional, Uxa, Amar, additional, Chow, Benjamin (Ben), additional, Hameed, Adnan, additional, Udell, Jacob, additional, Hamid, Magdy, additional, Hauguel-Moreau, Marie, additional, Furber, Alain, additional, Goube, Pascal, additional, Steg, Philippe-Gabriel, additional, Barone-Rochette, Gilles, additional, Thuaire, Christophe, additional, Slama, Michel, additional, Nickenig, Georg, additional, Bekeredjian, Raffi, additional, Schulze, P. Christian, additional, Merkely, Bela, additional, Fontos, Geza, additional, Vértes, András, additional, Varga, Albert, additional, Kumar, Ajit, additional, Nair, Rajesh G., additional, Grant, Purvez, additional, Manjunath, Cholenahally, additional, Moorthy, Nagaraja, additional, Satheesh, Santhosh, additional, Nath, Ranjit Kumar, additional, Wander, Gurpreet, additional, Christopher, Johann, additional, Dwivedi, Sudhanshu, additional, Oomman, Abraham, additional, Mathur, Atul, additional, Gadkari, Milind, additional, Naik, Sudhir, additional, Punnoose, Eapen, additional, Kachru, Ranjan, additional, Kaul, Upendra, additional, Kerner, Arthur, additional, Tarantini, Giuseppe, additional, Perna, Gian Piero, additional, Racca, Emanuela, additional, Mortara, Andrea, additional, Monti, Lorenzo, additional, Briguori, Carlo, additional, Leone, Gianpiero, additional, Amati, Roberto, additional, Salvatori, Mauro, additional, Di Chiara, Antonio, additional, Calabro, Paolo, additional, Galvani, Marcello, additional, Provasoli, Stefano, additional, Fukuda, Keiichi, additional, Nakano, Shintaro, additional, Laucevicius, Aleksandras, additional, Kedev, Sasko, additional, Khairuddin, Ahmad, additional, Riezebos, Robert, additional, Timmer, Jorik, additional, Heald, Spencer, additional, Stewart, Ralph, additional, Ramos, Walter Mogrovejo, additional, Demkow, Marcin, additional, Mazurek, Tomasz, additional, Drozdz, Jarozlaw, additional, Szwed, Hanna, additional, Witkowski, Adam, additional, Ferreira, Nuno, additional, Pinto, Fausto, additional, Ramos, Ruben, additional, Popescu, Bogdan, additional, Pop, Calin, additional, Bockeria, Leo, additional, Demchenko, Elena, additional, Romanov, Alexander, additional, Bershtein, Leonid, additional, Jizeeri, Ahmed, additional, Stankovic, Goran, additional, Apostolovic, Svetlana, additional, Adjic, Nada Cemerlic, additional, Zdravkovic, Marija, additional, Beleslin, Branko, additional, Dekleva, Milica, additional, Davidovic, Goran, additional, Chua, Terrance, additional, Foo, David, additional, Poh, Kian Keong, additional, Ntsekhe, Mpiko, additional, Sionis, Alessandro, additional, Marin, Francisco, additional, Miró, Vicente, additional, Blancas, Montserrat Gracida, additional, González-Juanatey, José, additional, Fernández-Avilés, Francisco, additional, Peteiro, Jesús, additional, Luena, Jose Enrique Castillo, additional, Aspberg, Johannes, additional, Rossi, Mariagrazia, additional, Kuanprasert, Srun, additional, Yamwong, Sukit, additional, Johnston, Nicola, additional, Donnelly, Patrick, additional, Moriarty, Andrew, additional, Elghamaz, Ahmed, additional, Gurunathan, Sothinathan, additional, Karogiannis, Nikolaos, additional, Shah, Benoy N., additional, Trimlett, Richard H.J., additional, Rubens, Michael B., additional, Nicol, Edward D., additional, Mittal, Tarun K., additional, Hampson, Reinette, additional, Gamma, Reto, additional, De Belder, Mark, additional, Nageh, Thuraia, additional, Lindsay, Steven, additional, Mavromatis, Kreton, additional, Miller, Todd, additional, Banerjee, Subhash, additional, Reynolds, Harmony, additional, Nour, Khaled, additional, and Stone, Peter, additional
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- 2023
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33. Cause-Specific Mortality in Patients With Advanced Chronic Kidney Disease in the ISCHEMIA-CKD Trial
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Sidhu, Mandeep S., primary, Alexander, Karen P., additional, Huang, Zhen, additional, Mathew, Roy O., additional, Newman, Jonathan D., additional, O’Brien, Sean M., additional, Pellikka, Patricia A., additional, Lyubarova, Radmila, additional, Bockeria, Olga, additional, Briguori, Carlo, additional, Kretov, Evgeny L., additional, Mazurek, Tomasz, additional, Orso, Francesco, additional, Roik, Marek F., additional, Sajeev, Chakkanalil, additional, Shutov, Evgeny V., additional, Rockhold, Frank W., additional, Borrego, David, additional, Balter, Stephen, additional, Stone, Gregg W., additional, Chaitman, Bernard R., additional, Goodman, Shaun G., additional, Fleg, Jerome L., additional, Reynolds, Harmony R., additional, Maron, David J., additional, Hochman, Judith S., additional, and Bangalore, Sripal, additional
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- 2023
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34. Effect of Baseline Exercise Capacity on Outcomes in Patients With Stable Coronary Heart Disease (A Post Hoc Analysis of the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation Trial)
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Padala, Santosh K., Sidhu, Mandeep S., Hartigan, Pamela M., Maron, David J., Teo, Koon K., Spertus, John A., Mancini, G.B. John, Sedlis, Steven P., Chaitman, Bernard R., Heller, Gary V., Weintraub, William S., and Boden, William E.
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- 2015
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35. Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial
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Carson, Jeffrey L, Sieber, Frederick, Cook, Donald Richard, Hoover, Donald R, Noveck, Helaine, Chaitman, Bernard R, Fleisher, Lee, Beaupre, Lauren, Macaulay, William, Rhoads, George G, Paris, Barbara, Zagorin, Aleksandra, Sanders, David W, Zakriya, Khwaja J, and Magaziner, Jay
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- 2015
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36. Comparison of Characteristics and Outcomes of Veterans With Stable Ischemic Heart Disease Enrolled in the COURAGE Trial Versus the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program
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Smilowitz, Nathaniel R., primary, Carey, Evan P., additional, Shah, Binita, additional, Hartigan, Pamela M., additional, Plomondon, Mary E., additional, Maron, David J., additional, Maddox, Thomas M., additional, Spertus, John A., additional, Mancini, G.B. John, additional, Chaitman, Bernard R., additional, Weintraub, William S., additional, Sedlis, Steven P., additional, and Boden, William E., additional
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- 2022
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37. Assessment of the 12-Lead Electrocardiogram as a Screening Test for Detection of Cardiovascular Disease in Healthy General Populations of Young People (12–25 Years of Age): A Scientific Statement From the American Heart Association and the American College of Cardiology
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Maron, Barry J., Friedman, Richard A., Kligfield, Paul, Levine, Benjamin D., Viskin, Sami, Chaitman, Bernard R., Okin, Peter M., Saul, J. Philip, Salberg, Lisa, Van Hare, George F., Soliman, Elsayed Z., Chen, Jersey, Matherne, G. Paul, Bolling, Steven F., Mitten, Matthew J., Caplan, Arthur, Balady, Gary J., and Thompson, Paul D.
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- 2014
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38. Predicting Outcome in the COURAGE Trial (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation): Coronary Anatomy Versus Ischemia
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Mancini, G.B. John, Hartigan, Pamela M., Shaw, Leslee J., Berman, Daniel S., Hayes, Sean W., Bates, Eric R., Maron, David J., Teo, Koon, Sedlis, Steven P., Chaitman, Bernard R., Weintraub, William S., Spertus, John A., Kostuk, William J., Dada, Marcin, Booth, David C., and Boden, William E.
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- 2014
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39. Myocardial Infarction in the ISCHEMIA Trial: Impact of Different Definitions on Incidence, Prognosis, and Treatment Comparisons.
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Chaitman, Bernard R, Chaitman, Bernard R, Alexander, Karen P, Cyr, Derek D, Berger, Jeffrey S, Reynolds, Harmony R, Bangalore, Sripal, Boden, William E, Lopes, Renato D, Demkow, Marcin, Piero Perna, Gian, Riezebos, Robert K, McFalls, Edward O, Banerjee, Subhash, Bagai, Akshay, Gosselin, Gilbert, O'Brien, Sean M, Rockhold, Frank W, Waters, David D, Thygesen, Kristian A, Stone, Gregg W, White, Harvey D, Maron, David J, Hochman, Judith S, ISCHEMIA Research Group, Chaitman, Bernard R, Chaitman, Bernard R, Alexander, Karen P, Cyr, Derek D, Berger, Jeffrey S, Reynolds, Harmony R, Bangalore, Sripal, Boden, William E, Lopes, Renato D, Demkow, Marcin, Piero Perna, Gian, Riezebos, Robert K, McFalls, Edward O, Banerjee, Subhash, Bagai, Akshay, Gosselin, Gilbert, O'Brien, Sean M, Rockhold, Frank W, Waters, David D, Thygesen, Kristian A, Stone, Gregg W, White, Harvey D, Maron, David J, Hochman, Judith S, and ISCHEMIA Research Group
- Abstract
BackgroundIn the ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches), an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality in comparison with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular end points was myocardial infarction (MI).MethodsISCHEMIA prespecified that the primary and major secondary composite end points of the trial be analyzed using 2 MI definitions. For procedural MI, the primary MI definition used creatine kinase-MB as the preferred biomarker, whereas the secondary definition used cardiac troponin. Procedural thresholds were >5 times the upper reference level for percutaneous coronary intervention and >10 times for coronary artery bypass grafting. Procedural MI definitions included (1) a category of elevated biomarker only events with much higher biomarker thresholds, (2) new ST-segment depression of ≥1 mm for the primary and ≥0.5 mm for the secondary definition, and (3) new coronary dissections >National Heart, Lung, and Blood Institute grade 3. We compared MI type, frequency, and prognosis by treatment assignment using both MI definitions.ResultsProcedural MIs accounted for 20.1% of all MI events with the primary definition and 40.6% of all MI events with the secondary definition. Four-year MI rates in patients undergoing revascularization were more frequent with the invasive versus conservative strategy using the primary (2.7% versus 1.1%; adjusted hazard ratio [HR], 2.98 [95% CI, 1.87-4.73]) and secondary (8.2% versus 2.0%; adjusted HR, 5.04 [95% CI, 3.64-6.97]) MI definitions. Type 1 MIs were less frequent with the invasive versus conservative strategy using the primary (3.40% versus 6.89%; adjusted HR, 0.53 [95% CI, 0.41-0.69]; P<0.0001) and secondary (3.48% versus 6.89%; adjusted HR, 0.53 [95% CI
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- 2021
40. 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials
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Hicks, Karen A., Mahaffey, Kenneth W., Mehran, Roxana, Nissen, Steven E., Wiviott, Stephen D., Dunn, Billy, Solomon, Scott D., Marler, John R., Teerlink, John R., Farb, Andrew, Morrow, David A., Targum, Shari L., Sila, Cathy A., Hai, Mary T. Thanh, Jaff, Michael R., Joffe, Hylton V., Cutlip, Donald E., Desai, Akshay S., Lewis, Eldrin F., Gibson, C. Michael, Landray, Martin J., Lincoff, A. Michael, White, Christopher J., Brooks, Steven S., Rosenfield, Kenneth, Domanski, Michael J., Lansky, Alexandra J., McMurray, John J.V., Tcheng, James E., Steinhubl, Steven R., Burton, Paul, Mauri, Laura, O’Connor, Christopher M., Pfeffer, Marc A., Hung, H.M. James, Stockbridge, Norman L., Chaitman, Bernard R., and Temple, Robert J.
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- 2018
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41. Exercise Testing
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Chaitman, Bernard R., Moinuddin, Masarrath J., Sano, Junko, Willerson, James T., editor, Wellens, Hein J. J., editor, Cohn, Jay N., editor, and Holmes, David R., Jr., editor
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- 2007
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42. Cardiovascular and Renal Implications of Myocardial Infarction in the ISCHEMIA-CKD Trial
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Chaitman, Bernard R., primary, Cyr, Derek D., additional, Alexander, Karen P., additional, Pracoń, Radosław, additional, Bainey, Kevin R., additional, Mathew, Anoop, additional, Acharya, Anjali, additional, Kunichoff, Dennis F., additional, Fleg, Jerome L., additional, Lopes, Renato D., additional, Sidhu, Mandeep S., additional, Anthopolos, Rebecca, additional, Rockhold, Frank W., additional, Stone, Gregg W., additional, Maron, David J., additional, Hochman, Judith S., additional, and Bangalore, Sripal, additional
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- 2022
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43. Low Levels of High-Density Lipoprotein Cholesterol and Increased Risk of Cardiovascular Events in Stable Ischemic Heart Disease Patients: A Post-Hoc Analysis From the COURAGE Trial (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation)
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Acharjee, Subroto, Boden, William E., Hartigan, Pamela M., Teo, Koon K., Maron, David J., Sedlis, Steven P., Kostuk, William, Spertus, John A., Dada, Marcin, Chaitman, Bernard R., Mancini, G.B. John, and Weintraub, William S.
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- 2013
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44. Risk Stratification : Exercise Testing, Imaging, and Cardiac Catheterization
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Puri, Sanjeev, Razek, Hani A., Chaitman, Bernard R., and Cannon, Christopher P., editor
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- 2003
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45. Clinical events classification (CEC) in clinical trials:Report on the current landscape and future directions — proceedings from the CEC Summit 2018
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Sharma, Abhinav, Mahaffey, Kenneth W., Gibson, Charles Michael, Hicks, Karen A., Alexander, Karen P., Ali, Maria, Chaitman, Bernard R., Held, Claes, Hlatky, Mark, Jones, WIlliam Schuyler, Mehran, Roxana, Menon, Venu, Rockhold, Frank W., Seltzer, Jonathan, Spitzer, Ernest, Wilson, Matthew, Lopes, Renato D., Sharma, Abhinav, Mahaffey, Kenneth W., Gibson, Charles Michael, Hicks, Karen A., Alexander, Karen P., Ali, Maria, Chaitman, Bernard R., Held, Claes, Hlatky, Mark, Jones, WIlliam Schuyler, Mehran, Roxana, Menon, Venu, Rockhold, Frank W., Seltzer, Jonathan, Spitzer, Ernest, Wilson, Matthew, and Lopes, Renato D.
- Abstract
Importance: Clinical events adjudication is pivotal for generating consistent and comparable evidence in clinical trials. The methodology of event adjudication is evolving, but research is needed to develop best practices and spur innovation. Observations: A meeting of stakeholders from regulatory agencies, academic and contract research organizations, pharmaceutical and device companies, and clinical trialists convened in Chicago, IL, for Clinical Events Classification (CEC) Summit 2018 to discuss key topics and future directions. Formal studies are lacking on strategies to optimize CEC conduct, improve efficiency, minimize cost, and generally increase the speed and accuracy of the event adjudication process. Major challenges to CEC discussed included ensuring rigorous quality of the process, identifying safety events, standardizing event definitions, using uniform strategies for missing information, facilitating interactions between CEC members and other trial leadership, and determining the CEC's role in pragmatic trials or trials using real-world data. Consensus recommendations from the meeting include the following: (1) ensure an adequate adjudication infrastructure; (2) use negatively adjudicated events to identify important safety events reported only outside the scope of the primary endpoint; (3) conduct further research in the use of artificial intelligence and digital/mobile technologies to streamline adjudication processes; and (4) emphasize the importance of standardizing event definitions and quality metrics of CEC programs. Conclusions and Relevance: As novel strategies for clinical trials emerge to generate evidence for regulatory approval and to guide clinical practice, a greater understanding of the role of the CEC process will be critical to optimize trial conduct and increase confidence in the data generated.
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- 2022
46. Third Universal Definition of Myocardial Infarction
- Author
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Thygesen, Kristian, Alpert, Joseph S., Jaffe, Allan S., Simoons, Maarten L., Chaitman, Bernard R., and White, Harvey D.
- Published
- 2012
- Full Text
- View/download PDF
47. Risk Stratification: Exercise Testing, Imaging, and Cardiac Catheterization
- Author
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Puri, Sanjeev, Chaitman, Bernard R., and Cannon, Christopher P., editor
- Published
- 1999
- Full Text
- View/download PDF
48. Effectiveness of Percutaneous Coronary Intervention in Patients With Silent Myocardial Ischemia (Post Hoc Analysis of the COURAGE Trial)
- Author
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Gosselin, Gilbert, Teo, Koon K., Tanguay, Jean-Francois, Gokhale, Rohit, Hartigan, Pamela M., Maron, David J., Gupta, Vipul, Mancini, G.B. John, Bates, Eric R., Chaitman, Bernard R., Spertus, John A., Kostuk, William J., Dada, Marcin, Sedlis, Steven P., Berman, Daniel S., Shaw, Leslee J., O'Rourke, Robert A., Weintraub, William S., and Boden, William E.
- Published
- 2012
- Full Text
- View/download PDF
49. RELATIONSHIP OF HEALTH STATUS TO ISCHEMIA AND CORONARY ANATOMY IN THE ISCHEMIA TRIAL
- Author
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Phillips, Lawrence M., primary, Hochman, Judith, additional, Maron, David Joel, additional, Shaw, Leslee J., additional, Berman, Daniel S., additional, Spertus, John A., additional, Mark, Daniel B., additional, Picard, Michael H., additional, Chaitman, Bernard R., additional, Jones, Philip, additional, Reynolds, Harmony, additional, Celutkiene, Jelena, additional, Stone, Gregg W., additional, Vitola, Joao V., additional, and Moorthy, Nagaraja, additional
- Published
- 2022
- Full Text
- View/download PDF
50. Mutagenesis and characterization of specific residues in fatty acid ethyl ester synthase: A gene for alcohol-induced cardiomyopathy
- Author
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Bora, Puran S., Miller, D. Douglas, Chaitman, Bernard R., Dhalla, Naranjan S., editor, Abdel-Aleem, Salah, editor, and Lowe, James E., editor
- Published
- 1998
- Full Text
- View/download PDF
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