Search

Your search keyword '"Chaikritsadakarn A"' showing total 6 results
Start Over Author "Chaikritsadakarn A"
6 results on '"Chaikritsadakarn A"'

2. TRANSGENERATIONAL EFFECT OF DI (2-ETHYLHEXYL) PHTHALATE (DEHP) EXPOSURE ON THE GROWTH AND REPRODUCTION OF MOINA MACROCOPA (CRUSTACEA: CLADOCERA).

Author

CHAIKRITSADAKARN, A., WITTHAYAWIRASAK, B., MUENPO, C., DELAUNE, R. D., and MUENHOR, D.

Subjects
CLADOCERA, CAPACITY building, RISK assessment, OXIDATIVE stress, CRUSTACEA
Abstract

Di-(2-ethylhexyl) phthalate (DEHP) is extensively used in plastic, which results in DEHP to appear in numerous environmental media worldwide. There is a lack of sufficient studies on the longterm transgenerational effect of DEHP exposure on the growth and reproduction of M. macrocopa. While non-fatal effects of DEHP exposure in M. macrocopa have been reported earlier, this study elucidates that DEHP exposure to parental water fleas had no adverse effects on offspring development or capacity for reproduction. The exposure for the parental generation through F2 progeny did not result in a concentration-dependent growing deleterious effect in subsequent generations, even with long-term exposure. These findings imply that DEHP exposure can cause oxidative stress, and that water flea (M. macrocopa) growth and reproduction were not significantly different from blank control and solvent control. The results of the present study aid in the understanding of DEHP risk assessment in aquatic systems. Moreover, the findings can be applied as baseline data to carry out future research on ecotoxicological risk assessment of DEHP. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Parental CuO nanoparticles exposure results in transgenerational toxicity in Caenorhabditis elegans associated with possible epigenetic regulation

Author

Chun-Han Chang, Vivian Hsiu-Chuan Liao, Pei-Ling Yen, Chia-Cheng Wei, Chi-Wei Huang, and Amornrat Chaikritsadakarn

Subjects
inorganic chemicals, Health, Toxicology and Mutagenesis, 0211 other engineering and technologies, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Epigenesis, Genetic, Transgenerational epigenetics, In vivo, Animals, Humans, Epigenetics, Caenorhabditis elegans, 0105 earth and related environmental sciences, 021110 strategic, defence & security studies, biology, Chemistry, Reproduction, technology, industry, and agriculture, Public Health, Environmental and Occupational Health, General Medicine, biology.organism_classification, Pollution, Cuo nanoparticles, Cell biology, Mrna level, Maternal Exposure, Toxicity, Nanoparticles, Female, Reproductive toxicity, Copper
Abstract

Environmental nanomaterials contamination is a great concern for organisms including human. Copper oxide nanoparticles (CuO NPs) are widely used in a huge range of applications which might pose potential risk to organisms. This study investigated the in vivo transgenerational toxicity on development and reproduction with parental CuO NPs exposure in the nematode Caenorhabditis elegans. The results showed that CuO NPs (150 mg/L) significantly reduced the body length of parental C. elegans (P0). Only about 1 mg/L Cu2+ (~0.73%) were detected from 150 mg/L CuO NPs in 0.5X K-medium after 48 h. In transgenerational assays, CuO NPs (150 mg/L) parental exposure significantly induced developmental and reproductive toxicity in non-exposed C. elegans progeny (CuO NPs free) on body length (F1) and brood size (F1 and F2), respectively. In contrast, parental exposure to Cu2+ (1 mg/L) did not cause transgenerational toxicity on growth and reproduction. This suggests that the transgenerational toxicity was mostly attributed to the particulate form of CuO NPs. Moreover, qRT-PCR results showed that the mRNA levels of met-2 and spr-5 genes were significantly decreased at P0 and F1 upon only maternal exposure to CuO NPs (150 mg/L), suggesting the observed transgenerational toxicity was associated with possible epigenetic regulation in C. elegans.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results