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AbstractLocal anesthetics have been used for temporary loss of pain, which limits their clinical application due to the neurotoxicity and short half-lives. In this present investigation, we have developed a novel k-carrageenan/alginate (k-CN/AGT) hydrogel loaded with Ropivacaine (RVN) to achieve a sustained release system. The synthesized k-CN/AGT hydrogels were examined for structural characterization, morphology, and mechanical properties. The observed studies revealed hydrogel has a suitable porous structure (0.5 to 5 µm) and effective swelling ratio with controlled in vitro release kinetics. The in vitro biocompatibility test on human dermal fibroblast cells confirmed that hydrogel has a nontoxic nature. The anesthetic activity of k-CN/AGT-RVN hydrogels was evaluated in vivo and compared with commercial formulations. Ex vivo permeation efficiency of k-CN/AGT-RVN hydrogels surpassed that of the RVN. As a result, the study demonstrated that k-CN/AGT-RVN hydrogels have the potential to prolong the effects of local anesthesia, offering a promising avenue for effective pain management. [ABSTRACT FROM AUTHOR]

Using the ANSYS finite element analysis software to analyze the modal of the case and its modules by the substructure method,the natural frequency and mode shape of the equipment are obtained. Synthesizing the results of the modal analysis,the comprehensive structure improvements recommendations are proposed. And the substructure method has important reference value for the large-scale electronic equipments.

Polycyclic aromatic hydrocarbons (PAHs) are key organic pollutants in the environment that pose threats to the ecosystem and human health. The degradation of high molecular weight (HMW) PAHs by enriched bacterial consortia has been previously studied, while the involved metabolisms and microbial communities are still unclear and warrant further investigations. In this study, five bacterial consortia capable of utilizing different PAHs (naphthalene, anthracene, and pyrene) as the sole carbon and energy sources were enriched from PAH-contaminated soil samples. Among the five consortia, consortium TC exhibited the highest pyrene degradation efficiency (91%) after 19 d of incubation. The degradation efficiency was further enhanced up to 99% by supplementing yeast extract. Besides, consortium TC showed tolerances to high concentrations of pyrene (up to 1000 mg/L) and different heavy metal stresses (including Zn2+, Cd2+, and Pb2+). The dominant genus in consortium TC, GS, and PL showing relatively higher degradation efficiency for anthracene and pyrene was Pseudomonas, whereas consortium PG and GD were predominated by genus Achromobacter and class Enterobacteriaceae, respectively. Consortium TC, as a highly efficient HMW PAH-degrading consortium, could be applied for synergistic biodegradation of HMW PAHs and in situ bioremediation of the sites contaminated with both PAHs and heavy metals. [ABSTRACT FROM AUTHOR]

Highly‐efficient photocatalytic conversion of CO2 into valuable carbon‐contained chemicals possesses a tremendous potential in solving the energy crisis and global warming problem. However, the inadequate separation of photogenerated electron‐hole pairs and the unsatisfied capture of CO2 stay the chief roadblocks. Herein, we designed a novel photocatalyst for CO2 reduction by assembling three‐dimensional graphene (3D GR) with a typical metal‐organic framework material UIO‐66‐NH2, aiming to construct a built‐in electric field for charge separation as well as taking advantage of the typical 3D structure of GR for maximizing the exposed absorption site on the surface. The performance evaluation demonstrated that the photocatalytic activity has been improved for the composite materials compared with that of the pure UIO‐66‐NH2. Further mechanism investigations proved that the enhanced photocatalytic performance is attributed to the synergy of enhanced CO2 absorption and inhibited photogenerated charge recombination, which could be owing to the better distribution and exposure of absorption and reaction sites on composites, and the redistribution of photogenerated carriers between 3D GR and UIO‐66‐NH2. This study provides a promising pathway to probe nanocomposites based on MOFs in environmental improvement and other relevant fields. [ABSTRACT FROM AUTHOR]

Highly‐efficient photocatalytic conversion of CO2 into valuable carbon‐contained chemicals possesses a tremendous potential in solving the energy crisis and global warming problem. However, the inadequate separation of photogenerated electron‐hole pairs and the unsatisfied capture of CO2 stay the chief roadblocks. Herein, we designed a novel photocatalyst for CO2 reduction by assembling three‐dimensional graphene (3D GR) with a typical metal‐organic framework material UIO‐66‐NH2, aiming to construct a built‐in electric field for charge separation as well as taking advantage of the typical 3D structure of GR for maximizing the exposed absorption site on the surface. The performance evaluation demonstrated that the photocatalytic activity has been improved for the composite materials compared with that of the pure UIO‐66‐NH2. Further mechanism investigations proved that the enhanced photocatalytic performance is attributed to the synergy of enhanced CO2 absorption and inhibited photogenerated charge recombination, which could be owing to the better distribution and exposure of absorption and reaction sites on composites, and the redistribution of photogenerated carriers between 3D GR and UIO‐66‐NH2. This study provides a promising pathway to probe nanocomposites based on MOFs in environmental improvement and other relevant fields. [ABSTRACT FROM AUTHOR]

Highly-efficient photocatalytic conversion of CO 2 into valuable carbon-contained chemicals possesses a tremendous potential in solving the energy crisis and global warming problem. However, the inadequate separation of photogenerated electron-hole pairs and the unsatisfied capture of CO 2 stay the chief roadblocks. Herein, we designed a novel photocatalyst for CO 2 reduction by assembling three-dimensional graphene (3D GR) with a typical metal-organic framework material UIO-66-NH 2 , aiming to construct a built-in electric field for charge separation as well as taking advantage of the typical 3D structure of GR for maximizing the exposed absorption site on the surface. The performance evaluation demonstrated that the photocatalytic activity has been improved for the composite materials compared with that of the pure UIO-66-NH 2 . Further mechanism investigations proved that the enhanced photocatalytic performance is attributed to the synergy of enhanced CO 2 absorption and inhibited photogenerated charge recombination, which could be owing to the better distribution and exposure of absorption and reaction sites on composites, and the redistribution of photogenerated carriers between 3D GR and UIO-66-NH 2 . This study provides a promising pathway to probe nanocomposites based on MOFs in environmental improvement and other relevant fields., (© 2022 Wiley-VCH GmbH.)