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664 results on '"Chagpar, Anees B."'

4. Concordance in Breast Cancer Grading by Artificial Intelligence on Whole Slide Images Compares With a Multi-Institutional Cohort of Breast Pathologists

Author

Mantrala, Siddhartha, Ginter, Paula S., Mitkari, Aditya, Joshi, Sripad, Prabhala, Harish, Ramachandra, Vikas, Kini, Lata, Idress, Romana, D'Alfonso, Timothy M., Fineberg, Susan, Jaffer, Shabnam, Sattar, Abida K., Chagpar, Anees B., Wilson, Parker, Singh, Kamaljeet, Harigopal, Malini, and Koka, Dinesh

Subjects
Clinical pathology -- Technology application, Artificial intelligence -- Usage, Pathologists -- Evaluation, Breast cancer -- Diagnosis, Computer-aided medical diagnosis -- Methods, Artificial intelligence, Technology application, Health
Abstract

* Context.--Breast carcinoma grade, as determined by the Nottingham Grading System (NGS), is an important criterion for determining prognosis. The NGS is based on 3 parameters: tubule formation (TF), nuclear pleomorphism (NP), and mitotic count (MC). The advent of digital pathology and artificial intelligence (AI) have increased interest in virtual microscopy using digital whole slide imaging (WSI) more broadly. Objective.--To compare concordance in breast carcinoma grading between AI and a multi-institutional group of breast pathologists using digital WSI. Design.--We have developed an automated NGS framework using deep learning. Six pathologists and AI independently reviewed a digitally scanned slide from 137 invasive carcinomas and assigned a grade based on scoring of the TF, NP, and MC. Results.--Interobserver agreement for the pathologists and AI for overall grade was moderate ([kappa] = 0.471). Agreement was good ([kappa] = 0.681), moderate ([kappa] = 0.442), and fair ([kappa] = 0.368) for grades 1, 3, and 2, respectively. Observer pair concordance for AI and individual pathologists ranged from fair to good ([kappa] = 0.313-0.606). Perfect agreement was observed in 25 cases (27.4%). Interobserver agreement for the individual components was best for TF ([kappa] = 0.471 each) followed by NP ([kappa] = 0.342) and was worst for MC ([kappa] = 0.233). There were no observed differences in concordance amongst pathologists alone versus pathologists + AI. Conclusions.--Ours is the first study comparing concordance in breast carcinoma grading between a multi-institutional group of pathologists using virtual microscopy to a newly developed WSI AI methodology. Using explainable methods, AI demonstrated similar concordance to pathologists alone. doi: 10.5858/arpa.2021-0299-OA, Over the years, microscopic evaluation of hematoxylin-eosin-stained slides from patient samples has been the gold standard for cancer diagnosis and grading of malignancy. The Nottingham Grading System (NGS) is widely [...]

Published
2022
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16. Impact of Cavity Shave Margins on Margin Status in Patients with Pure Ductal Carcinoma In Situ

Author

Howard-McNatt, Marissa, Dupont, Elisabeth, Tsangaris, Theodore, Garcia-Cantu, Carlos, Chiba, Akiko, Berger, Adam C., Levine, Edward A., Gass, Jennifer S., Ollila, David W., Gallagher, Kristalyn, Lum, Sharon S., Martinez, Ricardo D., Willis, Alliric I., Pandya, Sonali V., Brown, Eric A., Fenton, Andrew, Mendiola, Amanda, Murray, Mary, Haddad, Victor, Solomon, Naveenraj L., Senthil, Maheswari, Bansil, Hannah, Snyder, Samuel K., Edmonson, David, Lazar, Melissa, Namm, Jukes P., Li, Fangyong, Butler, Meghan, McGowan, Noreen E., Herrera, Maria E., Avitan, Yoana P., Yoder, Brian, McPartland, Tara, and Chagpar, Anees B.

Published
2021
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19. Do non-melanoma skin cancer survivors use tanning beds less often than the general public?

Author

Wiznia, Lauren, Dai, Feng, and Chagpar, Anees B

Abstract

Purpose Indoor tanning is associated with an increased risk of non-melanoma skin cancers (NMSC), yet little is known about indoor tanning habits of individuals with a history of NMSC. Methods We examined self-reported history of NMSC and tanning bed use among non-Hispanic white respondents in the 2010 National Health Interview Survey (NHIS), a cross-sectional population-based survey designed to be representative of the civilian US population. We computed weighted population estimates and standard errors using the Taylor series linearization method. We then evaluated chi-square tests of independence and conducted weighted logistic regression analyses to evaluate if NMSC status was a predictor of indoor tanning. Results In our analytic sample of 14,400 non-Hispanic white participants, representing 145,287,995 in the population, 543 participants (weighted proportion = 3.45%) self-reported a history of NMSC or “skin cancer type not known.” In multivariate analyses, non-melanoma skin cancer survivors were no less likely to use tanning beds in the last 12 months than skin cancer free controls (OR = 0.70, 95% CI: 0.34-1.43, p = 0.33). Conclusions Non-melanoma skin cancer survivors should be educated on their increased risk of recurrence and other skin cancers and in particular the role of indoor tanning in skin tumorigenesis.

Published
2016

20. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study

Author

Sanft, Tara, primary, Harrigan, Maura, additional, McGowan, Courtney, additional, Cartmel, Brenda, additional, Zupa, Michelle, additional, Li, Fang-Yong, additional, Ferrucci, Leah M., additional, Puklin, Leah, additional, Cao, Anlan, additional, Nguyen, Thai Hien, additional, Neuhouser, Marian L., additional, Hershman, Dawn L., additional, Basen-Engquist, Karen, additional, Jones, Beth A., additional, Knobf, Tish, additional, Chagpar, Anees B., additional, Silber, Andrea, additional, Tanasijevic, Anna, additional, Ligibel, Jennifer A., additional, and Irwin, Melinda L., additional

Published
2023
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23. Resection of Cavity Shave Margins in Stage 0–III Breast Cancer Patients Undergoing Breast Conserving Surgery: A Prospective Multicenter Randomized Controlled Trial

Author

Dupont, Elisabeth, Tsangaris, Theodore, Garcia-Cantu, Carlos, Howard-McNatt, Marissa, Chiba, Akiko, Berger, Adam C., Levine, Edward A., Gass, Jennifer S., Gallagher, Kristalyn, Lum, Sharon S., Martinez, Ricardo D., Willis, Alliric I., Pandya, Sonali V., Brown, Eric A., Fenton, Andrew, Mendiola, Amanda, Murray, Mary, Solomon, Naveenraj L., Senthil, Maheswari, Ollila, David W., Edmonson, David, Lazar, Melissa, Namm, Jukes P., Li, Fangyong, Butler, Meghan, McGowan, Noreen E., Herrera, Maria E., Avitan, Yoana P., Yoder, Brian, Walters, Laura L., McPartland, Tara, and Chagpar, Anees B.

Published
2021
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29. Resection of Cavity Shave Margins in Stage 0–III Breast Cancer Patients Undergoing Breast Conserving Surgery: A Prospective Multicenter Randomized Controlled Trial

Author

Dupont, Elisabeth, Tsangaris, Theodore, Garcia-Cantu, Carlos, Howard-McNatt, Marissa, Chiba, Akiko, Berger, Adam C., Levine, Edward A., Gass, Jennifer S., Gallagher, Kristalyn, Lum, Sharon S., Martinez, Ricardo D., Willis, Alliric I., Pandya, Sonali V., Brown, Eric A., Fenton, Andrew, Mendiola, Amanda, Murray, Mary, Solomon, Naveenraj L., Senthil, Maheswari, Ollila, David W., Edmonson, David, Lazar, Melissa, Namm, Jukes P., Li, Fangyong, Butler, Meghan, McGowan, Noreen E., Herrera, Maria E., Avitan, Yoana P., Yoder, Brian, Walters, Laura L., McPartland, Tara, and Chagpar, Anees B.

Published
2019
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31. Supplementary Data from Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study

Author

Ligibel, Jennifer A., primary, Dillon, Deborah, primary, Giobbie-Hurder, Anita, primary, McTiernan, Anne, primary, Frank, Elizabeth, primary, Cornwell, MacIntosh, primary, Pun, Matthew, primary, Campbell, Nancy, primary, Dowling, Ryan J.O., primary, Chang, Martin C., primary, Tolaney, Sara, primary, Chagpar, Anees B., primary, Yung, Rachel L., primary, Freedman, Rachel A., primary, Dominici, Laura S., primary, Golshan, Mehra, primary, Rhei, Esther, primary, Taneja, Krishan, primary, Huang, Ying, primary, Brown, Myles, primary, Winer, Eric P., primary, Jeselsohn, Rinath, primary, and Irwin, Melinda L., primary

Published
2023
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32. Supplementary Table 1 from Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer

Author

Hatzis, Christos, primary, Symmans, W. Fraser, primary, Zhang, Ya, primary, Gould, Rebekah E., primary, Moulder, Stacy L., primary, Hunt, Kelly K., primary, Abu-Khalaf, Maysa, primary, Hofstatter, Erin W., primary, Lannin, Donald, primary, Chagpar, Anees B., primary, and Pusztai, Lajos, primary

Published
2023
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33. Supplementary Table 2 from Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer

Author

Hatzis, Christos, primary, Symmans, W. Fraser, primary, Zhang, Ya, primary, Gould, Rebekah E., primary, Moulder, Stacy L., primary, Hunt, Kelly K., primary, Abu-Khalaf, Maysa, primary, Hofstatter, Erin W., primary, Lannin, Donald, primary, Chagpar, Anees B., primary, and Pusztai, Lajos, primary

Published
2023
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34. Abstract PD12-08: PD12-08 Randomized trial of exercise and nutrition on pathological complete response among women with breast cancer receiving neoadjuvant chemotherapy: the Lifestyle, Exercise and Nutrition Early after Diagnosis (LEANer) Study

Author

Ferrucci, Leah, primary, Sanft, Tara B., additional, Harrigan, Maura, additional, Cartmel, Brenda, additional, Li, Fangyong, additional, Zupa, Michelle, additional, McGowan, Courtney, additional, Puklin, Leah, additional, Nguyen, Thai Hien, additional, Tanasijevic, Anna M., additional, Neuhouser, Marian L., additional, Hershman, Dawn, additional, Basen-Engquist, Karen, additional, Jones, Beth, additional, Knobf, Tish, additional, Chagpar, Anees B., additional, Silber, Andrea L.M., additional, Ligibel, Jennifer A., additional, and Irwin, Melinda L., additional

Published
2023
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40. Omission of Radiation in Conservative Treatment for Breast Cancer: Opportunity for De-escalation of Care

Author

Hong, Michelle J., primary, Lum, Sharon S., additional, Dupont, Elisabeth, additional, Howard-McNatt, Marissa, additional, Chiba, Akiko, additional, Levine, Edward A., additional, Gass, Jennifer S., additional, Gallagher, Kristalyn, additional, Fenton, Andrew, additional, Murray, Mary, additional, Solomon, Naveenraj L., additional, Ollila, David W., additional, Lazar, Melissa, additional, Namm, Jukes P., additional, Walters, Laura L., additional, and Chagpar, Anees B., additional

Published
2022
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47. Are we choosing wisely? Drivers of preoperative MRI use in breast cancer patients

Author

Chagpar, Anees B., primary, Dupont, Elisabeth, additional, Chiba, Akiko, additional, Levine, Edward A., additional, Gass, Jennifer S., additional, Lum, Sharon, additional, Brown, Eric, additional, Fenton, Andrew, additional, Solomon, Naveenraj L., additional, Ollila, David W., additional, Murray, Mary, additional, Gallagher, Kristalyn, additional, Howard-McNatt, Marissa, additional, Lazar, Melissa, additional, Garcia-Cantu, Carlos, additional, Walters, Laura, additional, Pandya, Sonali, additional, Mendiola, Amanda, additional, and Namm, Jukes P., additional

Published
2022
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