Search

Your search keyword '"Chae, Soon Uk"' showing total 17 results
Start Over Author "Chae, Soon Uk"
17 results on '"Chae, Soon Uk"'

1. Assessment of the clinical pharmacokinetic interaction potential mediated So-Cheong-Ryong-Tang on a cocktail of anti-inflammatory and anti-biotic drugs, established by physiologically based pharmacokinetic modelings

Author

Kim, Da Hyun, primary, Lee, Chae Bin, additional, Chin, Sabin, additional, Lee, Sangyoung, additional, Jo, Seong Jun, additional, Chae, Soon Uk, additional, Kim, Duk Yeon, additional, Jerng, Ui Min, additional, and Bae, Soo Kyung, additional

Published
2024
Full Text
View/download PDF

9. A Sensitive, Simple, and Fast LC–MS/MS Method for Quantification of Remifentanil in Human Plasma: Applications in Critically Ill Patients' Plasma during Extracorporeal Membrane Oxygenation.

Author

Chae, Soon Uk, Kim, Ji Seon, Lee, Chae Bin, Jo, Seong Jun, Min, Kyung Lok, Chang, Min Jung, and Bae, Soo Kyung

Subjects
*LIQUID chromatography-mass spectrometry, *EXTRACORPOREAL membrane oxygenation, *ELECTROSPRAY ionization mass spectrometry, *REMIFENTANIL, *CRITICALLY ill, *MATRIX effect
Abstract

A sensitive, simple, and fast liquid chromatography–tandem mass spectrometry (LC–MS/MS) bioanalytical method was developed to determine remifentanil in human plasma and prevent its instability by esterases during quantification. A 20 μL sample of human plasma, acidified with formic acid, was precipitated using 100 μL of acetonitrile. Chromatography was carried out on an Agilent Poroshell 120 EC-C18 column (4.6 × 50 mm, 2.7 μm) with an isocratic elution by acetonitrile and distilled water containing 0.1% formic acid (65:35, v/v) at a flow rate of 0.5 mL/min. Transition ions were detected as m/z 377.10→113.20 and m/z 277.00→111.00 for remifentanil and chlorpropamide (internal standard), respectively, with positive electrospray ionization in mass spectrometry. The run time was only 3 min per sample. We evaluated the selectivity, linearity, carry-over, accuracy, precision, extraction recovery, absolute matrix effect, stability, and incurred sample reanalysis and found that all these parameters were within acceptable limits. The calibration curve range for remifentanil was 0.05–50 ng/mL with regression coefficient (r) values higher than 0.9939. Given the simple and fast sample preparation and the lower LLOQ concentration compared to those in other methods, this method was successfully used to quantify plasma levels after intravenous infusion of remifentanil to intensive-care-unit patients during extracorporeal membrane oxygenation. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

13. Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone

Author

Zheng, Yu Fen, primary, Bae, Soo Hyeon, additional, Huang, Zhouchi, additional, Chae, Soon Uk, additional, Jo, Seong Jun, additional, Shim, Hyung Joon, additional, Lee, Chae Bin, additional, Kim, Doyun, additional, Yoo, Hunseung, additional, and Bae, Soo Kyung, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results