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1. Genomic Testing in Patients with Kidney Failure of an Unknown Cause: a National Australian Study

Author

Mallawaarachchi, Amali C., Fowles, Lindsay, Wardrop, Louise, Wood, Alasdair, O’Shea, Rosie, Biros, Erik, Harris, Trudie, Alexander, Stephen I, Bodek, Simon, Boudville, Neil, Burke, Jo, Burnett, Leslie, Casauria, Sarah, Chadban, Steve, Chakera, Aron, Crafter, Sam, Dai, Pei, De Fazio, Paul, Faull, Randall, Honda, Andrew, Huntley, Vanessa, Jahan, Sadia, Jayasinghe, Kushani, Jose, Matthew, Leaver, Anna, MacShane, Mandi, Madelli, Evanthia Olympia, Nicholls, Kathy, Pawlowski, Rhonda, Rangan, Gopi, Snelling, Paul, Soraru, Jacqueline, Sundaram, Madhivanan, Tchan, Michel, Valente, Giulia, Wallis, Mathew, Wedd, Laura, Welland, Matthew, Whitlam, John, Wilkins, Ella J, McCarthy, Hugh, Simons, Cas, Quinlan, Catherine, Patel, Chirag, Stark, Zornitza, and Mallett, Andrew

Published
2024
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3. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Ahn, Curie, Alberú, Josefina, Baliker, Mary, Bamgboye, Ebun L., Barber, Thelma, Bensouda, Melissa, Chadban, Steve J., Dadhania, Darshana M., Dębska-Ślizień, Alicja, Devresse, Arnaud, Ditzen, Beate, Fowler, Kevin, Gill, John S., Jha, Vivekanand, Khairallah, Pascale, Knoll, Greg A., Korst, Uwe, Lee, Austin, Legendre, Christophe, Lentine, Krista L., Lerma, Edgar V., Lorenz, Elizabeth C., Matas, Arthur J., Mohan, Sumit, Nazarewski, Sławomir, Noronha, Irene L., Obrador, Gregorio T., Parekh, Rulan S., Pavlakis, Martha, Pascual, Julio, Pilmore, Helen L., Rosenkranz, Alexander R., Rozen-Zvi, Benaya, Roy-Chaudhury, Prabir, Tanabe, Kazunari, Wanner, Christoph, Wasse, Haimanot, Yang, Chul-Woo, Josephson, Michelle A., Becker, Yolanda, Budde, Klemens, Kasiske, Bertram L., Kiberd, Bryce A., Loupy, Alexandre, Małyszko, Jolanta, Mannon, Roslyn B., Tönshoff, Burkhard, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Zeier, Martin

Published
2023
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8. WCN24-888 INSIDE CKD - MAKING CKD DIAGNOSIS MORE COSTEFFECTIVE AND EFFICIENT BY USING A DIGITAL SOLUTION: A MODELLING STUDY ACROSS SIX COUNTRIES

Author

Solorzano, Jaime, primary, Batista, Marcelo Costa, additional, Chadban, Steve, additional, Al-Ghamdi, Saeed, additional, Goncalves, Susana, additional, Sanchez, Juan Garcia, additional, Cong, Luong Nguyen, additional, Cameron, Rory, additional, Powell, Camilla Sammut-, additional, Sisk, Rose, additional, Mitchyn, Markiyan, additional, Coker, Timothy, additional, Webber, Laura, additional, and RETAT, Lise, additional

Published
2024
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9. Developing Consensus-Based Priority Outcome Domains for Trials in Kidney Transplantation

Author

Sautenet, Bénédicte, Tong, Allison, Manera, Karine E, Chapman, Jeremy R, Warrens, Anthony N, Rosenbloom, David, Wong, Germaine, Gill, John, Budde, Klemens, Rostaing, Lionel, Marson, Lorna, Josephson, Michelle A, Reese, Peter P, Pruett, Timothy L, Hanson, Camilla S, O’Donoghue, Donal, Tam-Tham, Helen, Halimi, Jean-Michel, Shen, Jenny I, Kanellis, John, Scandling, John D, Howard, Kirsten, Howell, Martin, Cross, Nick, Evangelidis, Nicole, Masson, Philip, Oberbauer, Rainer, Fung, Samuel, Jesudason, Shilpa, Knight, Simon, Mandayam, Sreedhar, McDonald, Stephen P, Chadban, Steve, Rajan, Tasleem, and Craig, Jonathan C

Subjects
Clinical Research, Kidney Disease, Transplantation, Organ Transplantation, Behavioral and Social Science, Renal and urogenital, Good Health and Well Being, Adolescent, Adult, Aged, Caregivers, Clinical Trials as Topic, Consensus, Delphi Technique, Health Personnel, Humans, Kidney Transplantation, Middle Aged, Outcome Assessment, Health Care, Surveys and Questionnaires, Young Adult, Medical and Health Sciences, Surgery
Abstract

BackgroundInconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value of trials in treatment decision making. We identified critically important outcome domains in kidney transplantation based on the shared priorities of patients/caregivers and health professionals.MethodsIn a 3-round Delphi survey, patients/caregivers and health professionals rated the importance of outcome domains for trials in kidney transplantation on a 9-point Likert scale and provided comments. During rounds 2 and 3, participants rerated the outcomes after reviewing their own score, the distribution of the respondents' scores, and comments. We calculated the median, mean, and proportion rating 7 to 9 (critically important), and analyzed comments thematically.ResultsOne thousand eighteen participants (461 [45%] patients/caregivers and 557 [55%] health professionals) from 79 countries completed round 1, and 779 (77%) completed round 3. The top 8 outcomes that met the consensus criteria in round 3 (mean, ≥7.5; median, ≥8; proportion, >85%) in both groups were graft loss, graft function, chronic rejection, acute rejection, mortality, infection, cancer (excluding skin), and cardiovascular disease. Compared with health professionals, patients/caregivers gave higher priority to 6 outcomes (mean difference of 0.5 or more): skin cancer, surgical complications, cognition, blood pressure, depression, and ability to work. We identified 5 themes: capacity to control and inevitability, personal relevance, debilitating repercussions, gaining awareness of risks, and addressing knowledge gaps.ConclusionsGraft complications and severe comorbidities were critically important for both stakeholder groups. These stakeholder-prioritized outcomes will inform the core outcome set to improve the consistency and relevance of trials in kidney transplantation.

Published
2017

11. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Josephson, Michelle A., primary, Becker, Yolanda, additional, Budde, Klemens, additional, Kasiske, Bertram L., additional, Kiberd, Bryce A., additional, Loupy, Alexandre, additional, Małyszko, Jolanta, additional, Mannon, Roslyn B., additional, Tönshoff, Burkhard, additional, Cheung, Michael, additional, Jadoul, Michel, additional, Winkelmayer, Wolfgang C., additional, Zeier, Martin, additional, Ahn, Curie, additional, Alberú, Josefina, additional, Baliker, Mary, additional, Bamgboye, Ebun L., additional, Barber, Thelma, additional, Bensouda, Melissa, additional, Chadban, Steve J., additional, Dadhania, Darshana M., additional, Dębska-Ślizień, Alicja, additional, Devresse, Arnaud, additional, Ditzen, Beate, additional, Fowler, Kevin, additional, Gill, John S., additional, Jha, Vivekanand, additional, Khairallah, Pascale, additional, Knoll, Greg A., additional, Korst, Uwe, additional, Lee, Austin, additional, Legendre, Christophe, additional, Lentine, Krista L., additional, Lerma, Edgar V., additional, Lorenz, Elizabeth C., additional, Matas, Arthur J., additional, Mohan, Sumit, additional, Nazarewski, Sławomir, additional, Noronha, Irene L., additional, Obrador, Gregorio T., additional, Parekh, Rulan S., additional, Pavlakis, Martha, additional, Pascual, Julio, additional, Pilmore, Helen L., additional, Rosenkranz, Alexander R., additional, Rozen-Zvi, Benaya, additional, Roy-Chaudhury, Prabir, additional, Tanabe, Kazunari, additional, Wanner, Christoph, additional, Wasse, Haimanot, additional, and Yang, Chul-Woo, additional

Published
2023
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15. Two-year outcomes in de novo renal transplant recipients receiving everolimus-facilitated calcineurin inhibitor reduction regimen from the TRANSFORM study

Author

Berger, Stefan P., Sommerer, Claudia, Witzke, Oliver, Tedesco, Helio, Chadban, Steve, Mulgaonkar, Shamkant, Qazi, Yasir, de Fijter, Johan W., Oppenheimer, Federico, Cruzado, Josep M., Watarai, Yoshihiko, Massari, Pablo, Legendre, Christophe, Citterio, Franco, Henry, Mitchell, Srinivas, Titte R., Vincenti, Flavio, Gutierrez, Maria Pilar Hernandez, Marti, Ana Maria, Bernhardt, Peter, and Pascual, Julio

Published
2019
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16. Safety and efficacy of eculizumab for the prevention of antibody-mediated rejection after deceased-donor kidney transplantation in patients with preformed donor-specific antibodies

Author

Glotz, Denis, Russ, Graeme, Rostaing, Lionel, Legendre, Christophe, Tufveson, Gunnar, Chadban, Steve, Grinyó, Josep, Mamode, Nizam, Rigotti, Paolo, Couzi, Lionel, Büchler, Matthias, Sandrini, Silvio, Dain, Bradley, Garfield, Mary, Ogawa, Masayo, Richard, Tristan, and Marks, William H.

Published
2019
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24. Safety of Everolimus With Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplants: An Analysis From the Randomized TRANSFORM Study

Author

Tedesco-Silva, Helio, Pascual, Julio, Viklicky, Ondrej, Basic-Jukic, Nikolina, Cassuto, Elisabeth, Kim, Dean Y., Cruzado, Josep M., Sommerer, Claudia, Adel Bakr, Mohamed, Garcia, Valter D., Uyen, Huynh-Do, Russ, Graeme, Soo Kim, Myoung, Kuypers, Dirk, Buchler, Matthias, Citterio, Franco, Hernandez Gutierrez, Maria Pilar, Bernhardt, Peter, and Chadban, Steve

Published
2019
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26. Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis.

Author

Grams, Morgan E., Coresh, Josef, Matsushita, Kunihiro, Ballew, Shoshana H., Sang, Yingying, Surapaneni, Aditya, Alencar de Pinho, Natalia, Anderson, Amanda, Appel, Lawrence J., Ärnlöv, Johan, Azizi, Fereidoun, Bansal, Nisha, Bell, Samira, Bilo, Henk J. G., Brunskill, Nigel J., Carrero, Juan J., Chadban, Steve, Chalmers, John, Chen, Jing, and Ciemins, Elizabeth

Subjects
HEART failure, GLOMERULAR filtration rate, KIDNEY failure, ALBUMINURIA, CYSTATIN C, PERIPHERAL vascular diseases, ACUTE kidney failure
Abstract

Key Points: Question: Are lower values for estimated glomerular filtration rate (eGFR based on either creatinine alone or creatinine and cystatin C) and more severe albuminuria associated with adverse kidney and cardiovascular outcomes? Findings: In this retrospective individual-level data analysis of 27 503 140 individuals from 114 cohorts, lower eGFR and more severe albuminuria were each associated with higher rates of adverse kidney outcomes, including kidney failure with replacement therapy and acute kidney injury. Lower eGFR and more severe albuminuria also were associated with adverse cardiovascular outcomes, including cardiovascular mortality, heart failure, and atrial fibrillation. Meaning: Lower eGFR values and more severe albuminuria were associated with multiple adverse outcomes. Importance: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. Objective: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. Design, Setting, and Participants: Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021. Exposures: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR). Main Outcomes and Measures: The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses. Results: Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 11 mg/g (IQR, 8-16 mg/g). Within the population using eGFR based on creatinine and cystatin C (mean age, 59 years [SD, 12 years]; 53% were women; mean follow-up time, 10.8 years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 9 mg/g (IQR, 6-18 mg/g). Lower eGFR (whether based on creatinine alone or based on creatinine and cystatin C) and higher UACR were each significantly associated with higher risk for each of the 10 adverse outcomes, including those in the mildest categories of chronic kidney disease. For example, among people with a UACR less than 10 mg/g, an eGFR of 45 to 59 mL/min/1.73 m2 based on creatinine alone was associated with significantly higher hospitalization rates compared with an eGFR of 90 to 104 mL/min/1.73 m2 (adjusted hazard ratio, 1.3 [95% CI, 1.2-1.3]; 161 vs 79 events per 1000 person-years; excess absolute risk, 22 events per 1000 person-years [95% CI, 19-25 events per 1000 person-years]). Conclusions and Relevance: In this retrospective analysis of 114 cohorts, lower eGFR based on creatinine alone, lower eGFR based on creatinine and cystatin C, and more severe UACR were each associated with increased rates of 10 adverse outcomes, including adverse kidney outcomes, cardiovascular diseases, and hospitalizations. This individual-participant data meta-analysis of 114 cohorts evaluates associations of lower estimated glomerular filtration rate (eGFR) based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Laparoscopic donor nephrectomy—Technique and peri‐operative outcomes in an Australian transplant center

Author

Jackson, Stuart, primary, Combes, Alexander, additional, Latif, Edward, additional, Tran, Minh, additional, Lam, Susanna, additional, Gore, Neel, additional, Utsiwegota, Mike, additional, Mawson, Jane, additional, Smith, Laura, additional, Palma, Catalina, additional, Laurence, Jerome, additional, Crawford, Michael, additional, Pulitano, Carlo, additional, Wyburn, Kate, additional, Chadban, Steve, additional, Leslie, Scott, additional, and Vasilaras, Arthur, additional

Published
2023
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28. Research Priorities in CKD: Report of a National Workshop Conducted in Australia

Author

Tong, Allison, Crowe, Sally, Chando, Shingisai, Cass, Alan, Chadban, Steve J., Chapman, Jeremy R., Gallagher, Martin, Hawley, Carmel M., Hill, Sophie, Howard, Kirsten, Johnson, David W., Kerr, Peter G., McKenzie, Anne, Parker, David, Perkovic, Vlado, Polkinghorne, Kevan R., Pollock, Carol, Strippoli, Giovanni F.M., Tugwell, Peter, Walker, Rowan G., Webster, Angela C., Wong, Germaine, and Craig, Jonathan C.

Published
2015
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31. Establishing a Core Outcome Measure for Graft Health: A Standardized Outcomes in Nephrology-Kidney Transplantation (SONG-Tx) Consensus Workshop Report

Author

Tong, Allison, Sautenet, Benedicte, Poggio, Emilio D., Lentine, Krista L., Oberbauer, Rainer, Mannon, Roslyn, Murphy, Barbara, Padilla, Benita, Chow, Kai Ming, Marson, Lorna, Chadban, Steve, Craig, Jonathan C., Ju, Angela, Manera, Karine E., Hanson, Camilla S., Josephson, Michelle A., and Knoll, Greg

Published
2018
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38. sj-docx-1-cjk-10.1177_20543581221084499 ��� Supplemental material for Patient and Clinician Perspectives on the use of Remote Patient Monitoring in Peritoneal Dialysis

Author

Talbot, Benjamin, Farnbach, Sara, Tong, Allison, Chadban, Steve, Sen, Shaundeep, Garvey, Vincent, Gallagher, Martin, and Knight, John

Subjects
Medicine
Abstract

Supplemental material, sj-docx-1-cjk-10.1177_20543581221084499 for Patient and Clinician Perspectives on the use of Remote Patient Monitoring in Peritoneal Dialysis by Benjamin Talbot, Sara Farnbach, Allison Tong, Steve Chadban, Shaundeep Sen, Vincent Garvey, Martin Gallagher and John Knight in Canadian Journal of Kidney Health and Disease

Published
2022
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39. Interactions Between Donor Age and 12-Month Estimated Glomerular Filtration Rate on Allograft and Patient Outcomes After Kidney Transplantation

Author

Lim, Wai H., primary, Ooi, Esther, additional, Pilmore, Helen L., additional, Johnson, David W., additional, McDonald, Stephen P., additional, Clayton, Philip, additional, Hawley, Carmel, additional, Mulley, William R., additional, Francis, Ross, additional, Collins, Michael G., additional, Jaques, Bryon, additional, Larkins, Nicholas G., additional, Davies, Christopher E., additional, Wyburn, Kate, additional, Chadban, Steve J., additional, and Wong, Germaine, additional

Published
2022
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45. Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: proof-of-concept study

Author

Aubert, Olivier, primary, Divard, Gillian, additional, Pascual, Julio, additional, Oppenheimer, Federico, additional, Sommerer, Claudia, additional, Citterio, Franco, additional, Tedesco, Helio, additional, Chadban, Steve, additional, Henry, Mitchell, additional, Vincenti, Flavio, additional, Srinivas, Titte, additional, Watarai, Yoshihiko, additional, Legendre, Christophe, additional, Bernhardt, Peter, additional, and Loupy, Alexandre, additional

Published
2021
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49. Kidney transplant recipient perspectives on telehealth during the COVID‐19 pandemic

Author

Huuskes, Brooke M, primary, Scholes‐Robertson, Nicole, additional, Guha, Chandana, additional, Baumgart, Amanda, additional, Wong, Germaine, additional, Kanellis, John, additional, Chadban, Steve, additional, Barraclough, Katherine A., additional, Viecelli, Andrea K, additional, Hawley, Carmel M., additional, Kerr, Peter G., additional, Toby Coates, Patrick, additional, Amir, Noa, additional, and Tong, Allison, additional

Published
2021
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50. 1051-P: Inside CKD: Modeling the Future Global Burden of Chronic Kidney Disease in Patients with Type 2 Diabetes

Author

SANCHEZ, JUAN JOSE GARCIA, primary, SULTAN, ALYSHAH ABDUL, additional, ÄRNLÖV, JOHAN, additional, BATISTA, MARCELO C., additional, CABRERA, CLAUDIA, additional, CARD-GOWERS, JOSHUA, additional, CHADBAN, STEVE, additional, CHERTOW, GLENN M., additional, DENICOLA, LUCA, additional, HALIMI, JEAN-MICHEL, additional, KANDA, EIICHIRO, additional, LI, GUISEN, additional, MENNINI, FRANCESCO SAVERIO, additional, NAVARRO-GONZALEZ, JUAN, additional, NOLAN, STEPHEN T., additional, POWER, ALBERT, additional, RETAT, LISE, additional, TANGRI, NAVDEEP, additional, WEBBER, LAURA, additional, WISH, JAY, additional, and XU, MICHAEL, additional

Published
2021
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