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213 results on '"Chacko R"'

1. An unusual injury from a toothbrush: A case report

Author

Ebenezer J, Adhikari D, Mathew G, and Chacko R

Subjects
Buccal mucosa, toothbrush, trauma, Dentistry, RK1-715
Abstract

The use of toothbrushes has significantly improved oral hygiene. However, if brushing of the teeth is not done judiciously, it could result in severe trauma to the soft tissues of the oral cavity. This is particularly true in the young age group, since children tend to be very playful while brushing their teeth. This article describes the case report of a child who sustained a penetrating injury while brushing his teeth. A detailed plan for the management of such injuries is also presented.

Published
2007

11. Analysis of Al diffusion processes in TiN barrier layers for the application in silicon solar cell metallization.

Author

Kumm, J., Samadi, H., Chacko, R. V., Hartmann, P., and Wolf, A.

Subjects
ALUMINUM, TITANIUM, DIFFUSION, SOLAR cells, SILICON
Abstract

An evaporated Al layer is known as an excellent rear metallization for highly efficient solar cells, but suffers from incompatibility with a common solder process. To enable solar cellinterconnection and module integration, in this work the Al layer is complemented with a solder stack of TiN/Ti/Ag or TiN/NiV/Ag, in which the TiN layer acts as an Al diffusion barrier. X-ray photoelectron spectroscopy measurements prove that diffusion of Al through the stack and the formation of an Al2O3 layer on the stack's surface are responsible for a loss of solderability after a strong post-metallization anneal, which is often mandatory to improve contact resistance and passivation quality. An optimization of the reactive TiN sputter process results in a densification of the TiN layer, which improves its barrier quality against Al diffusion. However, measurements with Xray diffraction and scanning electron microscopy show that small grains with vertical grain boundaries persist, which still offer fast diffusion paths. Therefore, the concept of stuffing is introduced. By incorporating oxygen into the grain boundaries of the sputtered TiN layer, Al diffusion is strongly reduced as confirmed by secondary ion mass spectroscopy profiles. A quantitative analysis reveals a one order of magnitude lower Al diffusion coefficient for stuffed TiN layers. This metallization system maintains its solderability even after strong post-metallization annealing at 425 °C for 15 min. This paper thus presents an industrially feasible, conventionally solderable, and longterm stable metallization scheme for highly efficient silicon solar cells. [ABSTRACT FROM AUTHOR]

Published
2016
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12. Estimation of reactive inorganic iodine fluxes in the Indian and Southern Ocean marine boundary layer

Author

Ministry of Earth Sciences (India), Natural Environment Research Council (UK), Inamdar, Swaleha, Tinel, L., Chance, R., Carpenter, L.J., Sabu, P., Chacko, R., Tripathy, S.C., Kerkar, A.U., Sinha, A.K., Venkateswaran Bhaskar, P., Sarkar, A., Roy, R., Sherwen, T., Cuevas, Carlos A., Saiz-Lopez, A., Ram, K., Mahajan, Anoop S., Ministry of Earth Sciences (India), Natural Environment Research Council (UK), Inamdar, Swaleha, Tinel, L., Chance, R., Carpenter, L.J., Sabu, P., Chacko, R., Tripathy, S.C., Kerkar, A.U., Sinha, A.K., Venkateswaran Bhaskar, P., Sarkar, A., Roy, R., Sherwen, T., Cuevas, Carlos A., Saiz-Lopez, A., Ram, K., and Mahajan, Anoop S.

Abstract

Iodine chemistry has noteworthy impacts on the oxidising capacity of the marine boundary layer (MBL) through the depletion of ozone (O3) and changes to HOx (OH=HO2) and NOx (NO=NO2) ratios. Hitherto, studies have shown that the reaction of atmospheric O3 with surface seawater iodide (I-) contributes to the flux of iodine species into the MBL mainly as hypoiodous acid (HOI) and molecular iodine (I2). Here, we present the first concomitant observations of iodine oxide (IO), O3 in the gas phase, and sea surface iodide concentrations. The results from three field campaigns in the Indian Ocean and the Southern Ocean during 2015 2017 are used to compute reactive iodine fluxes in the MBL. Observations of atmospheric IO by multi-axis differential optical absorption spectroscopy (MAX-DOAS) show active iodine chemistry in this environment, with IO values up to 1 pptv (parts per trillion by volume) below latitudes of 40° S. In order to compute the sea-to-air iodine flux supporting this chemistry, we compare previously established global sea surface iodide parameterisations with new regionspecific parameterisations based on the new iodide observations. This study shows that regional changes in salinity and sea surface temperature play a role in surface seawater iodide estimation. Sea air fluxes of HOI and I2, calculated from the atmospheric ozone and seawater iodide concentrations (observed and predicted), failed to adequately explain the detected IO in this region. This discrepancy highlights the need to measure direct fluxes of inorganic and organic iodine species in the marine environment. Amongst other potential drivers of reactive iodine chemistry investigated, chlorophyll a showed a significant correlation with atmospheric IO (R D 0:7 above the 99 % significance level) to the north of the polar front. This correlation might be indicative of a biogenic control on iodine sources in this region.

Published
2020

13. Practical recommendation for rash and diarrhea management in Indian patients treated with tyrosine kinase inhibitors for the treatment of non-small cell lung cancer

Author

Parikh, P., Prabhash, K., Naik, R., Vaid, A., Goswami, C., Rajappa, S., Noronha, V., Joshi, A., Chacko, R., Aggarwal, S., and Doval, D.

Subjects
Tyrosine -- Health aspects -- Research, Rash -- Care and treatment, Diarrhea -- Care and treatment, Non-small cell lung cancer -- Care and treatment, Health
Abstract

Byline: P. Parikh, K. Prabhash, R. Naik, A. Vaid, C. Goswami, S. Rajappa, V. Noronha, A. Joshi, R. Chacko, S. Aggarwal, D. Doval Tyrosine kinase inhibitors (TKIs) are a pharmaceutical [...]

Published
2016

14. Carcinoma of the gallbladder presenting with multiple osseous and inguinal lymph node metastases

Author

Joel, A., Samuel, A., Bhatt, A., Chandramohan, A., and Chacko, R.

Subjects
Lymphatic diseases -- Case studies -- Development and progression -- Care and treatment, Bone tumors -- Case studies -- Development and progression -- Care and treatment, Gallbladder cancer -- Case studies -- Complications and side effects -- Care and treatment, Cancer metastasis -- Case studies -- Care and treatment, Health
Abstract

Byline: A. Joel, A. Samuel, A. Bhatt, A. Chandramohan, R. Chacko Sir, A 76-year-old male presented to our outpatient clinic with a 3-month history of generalized bone pain, tiredness, and [...]

Published
2015

16. ICON 2013: Practical consensus recommendations for hormone receptor-positive Her2-negative advanced or metastatic breastcancer

Author

Parikh, P., Gupta, S., Dawood, S., Rugo, H., Bhattacharyya, G., Agarwal, A., Chacko, R., Sahoo, T., Babu, G., Agarwal, S., Munshi, A., Goswami, C., Smruti, B., Bondarde, S., Desai, C., Rajappa, S., Somani, N., Singh, M., Nimmagadda, R., Pavitran, K., Mehta, A., Parmar, V., Desai, S., Nair, R., and Doval, D.

Subjects
Metastasis -- Care and treatment, Hormone receptors -- Health aspects, Practice guidelines (Medicine), Medical societies -- Standards, Cancer -- Care and treatment, Breast cancer -- Care and treatment, Health
Abstract

Byline: P. Parikh, S. Gupta, S. Dawood, H. Rugo, G. Bhattacharyya, A. Agarwal, R. Chacko, T. Sahoo, G. Babu, S. Agarwal, A. Munshi, C. Goswami, B. Smruti, S. Bondarde, C. [...]

Published
2014

17. Clinicopathologic features of non-small cell lung cancer in India and correlation with epidermal growth factor receptor mutational status

Author

Bhatt, A., Pai, R., Rebekah, G., Nehru, G., Dhananjayan, S., Samuel, A., Singh, A., Joel, A., Korula, A., and Chacko, R.

Subjects
Lung cancer, Small cell -- Genetic aspects -- Care and treatment -- Analysis, Cancer -- Care and treatment, Lung cancer, Non-small cell -- Genetic aspects -- Care and treatment -- Analysis, Epidermal growth factor -- Analysis, Health, International Association for the Study of Lung Cancer
Abstract

Byline: A. Bhatt, R. Pai, G. Rebekah, G. Nehru, S. Dhananjayan, A. Samuel, A. Singh, A. Joel, A. Korula, R. Chacko Introduction: We performed retrospective analysis of 106 patients with [...]

Published
2013

19. Current Treatment Options for Human Epidermal Growth Factor Receptor 2-Directed Therapy in Metastatic Breast Cancer: An Indian Perspective

Author

Sudeep, Gupta, additional, Sanjoy, Chatterjee, additional, Jagdish, Nigade, additional, Shyam, Aggarwal, additional, Manish, Singhal, additional, Alurkar, SS, additional, Anil, Kukreja, additional, Smruti, BK, additional, Shona, Nag, additional, Amit, Agarwal, additional, Vijay, Agarwal, additional, Chacko, R, additional, Chirag, Desai, additional, Chanchal, Goswami, additional, Pavithran, Keechilat, additional, Poonam, Patil, additional, Krishna, Prasad, additional, Rejiv, Rajendranath, additional, Rao, RR, additional, Sahoo, TP, additional, Ashish, Singh, additional, Randeep, Singh, additional, Sankar, Srinivasan, additional, Arun, Warrier, additional, Binay, Swarup, additional, Priyanka, Bhattacharya, additional, and Advani, SH, additional

Published
2018
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28. Single- vs. Multiple-Item Instruments in the Assessment of Quality of Life in Patients with Advanced Cancer.

Author

Bruera E., Bush S.H., Parsons H.A., Palmer J.L., Li Z., Chacko R., Bruera E., Bush S.H., Parsons H.A., Palmer J.L., Li Z., and Chacko R.

Abstract

Although multidimensional instruments are usually used to measure quality of life in advanced cancer patients, recent research suggests that single-item assessments can provide a reliable measure. Using the Functional Assessment of Cancer Therapy-General (FACT-G) instrument as a gold standard, we assessed the performance of the Edmonton Symptom Assessment System "feeling of well-being" (ESAS WB) item. We reviewed the data from 213 patients enrolled in six clinical trials. We determined the association between baseline ESAS WB and FACT-G total and subscale domain scores (Physical Well-being [PWB], Social/Family Well-being [SWB], Emotional Well-being [EWB], and Functional Well-being [FWB]. We also calculated the association between baseline (T1) and second (T2) observations of ESAS WB and of FACT-G total score. In addition, we predicted the change in FACT-G predicted by the ESAS WB score using regression analysis. Mean age was 60 (SD 12) years and 48% were female. The Spearman correlation coefficient of ESAS WB and FACT-G was -0.48 (P < 0.0001). Correlations with FACT-G subscale domains were also highly significant, except for the SWB domain (P = 0.08). The Pearson correlation coefficient for T1-T2 in ESAS WB and FACT-G for 146 patients was -0.36 (P < 0.0001). The change in ESAS WB corresponding to FACT-G published minimally important difference was -0.24 for 3, -1.55 for 5, and -2.87 for 7, respectively. These results suggest that the single-item measure ESAS WB best reflects the total score on the FACT-G and PWB, EWB, and FWB domains but not on the SWB domain. © 2010 U.S. Cancer Pain Relief Committee.

Published
2012

29. The assessment of quality of life in palliative cancer care: Single versus multiple item tools.

Author

Palmer J.L., Parsons A.H., Li Z., Bruera E., Chacko R., Bush H.S., Palmer J.L., Parsons A.H., Li Z., Bruera E., Chacko R., and Bush H.S.

Abstract

Objectives: The improvement of quality of life (QOL) is a cornerstone of good palliative care. QOL is a subjective and complex multi-dimensional concept, so it is usually measured using multi-dimensional instruments. Recently, authors have suggested that brief single-item global assessments can provide a reliable measure of overall QOL. Using the Functional Assessment of Cancer Therapy - General (FACT-G) instrument as a gold standard, we assessed the performance of the Edmonton Symptom Assessment System 'feeling of well-being' item (ESAS WB). Method(s): After obtaining IRB approval, we retrospectively reviewed the data from six prospective clinical trials conducted by our group in advanced cancer patients. We determined the levels of association between baseline ESAS WB and FACT-G total and subscale domain scores (Physical (Pwb), Social/Family (Swb), Emotional (Ewb), and Functional (Fwb) Well-Being) and also between the nine ESAS symptom intensity scores using Spearman correlation coefficients. We also calculated the change between the baseline (T1) and second (T2) observations of ESAS WB and of FACT-G total score and determined their level of association using a Pearson correlation coefficient. We also predicted the change in FACT-G as predicted by the ESAS WB score using regression analysis. Result(s): Mean age of the 218 trial participants was 60 (SD 12) years and 48% were female. Spearman correlations between ESAS WB and FACT-G and ESAS scores are shown in the table. The Pearson correlation coefficient for T1 - T2 in ESAS WB and FACT-G for 146 patients was - 0.36 (p<0.0001). The regression analysis was highly significant (p<0.0001). The change in ESAS WB corresponding to FACT-G published minimally important difference (MID) was -0.24 for 3, -1.55 for 5, and -2.87 for 7, respectively. Conclusion(s): ESAS WB is a practical instrument for the clinical setting but appears to correlate less well with the Swb domain of FACT-G.

Published
2009

37. Updated activity and safety results of a phase II randomized discontinuation trial (RDT) of AV-951, a potent and selective VEGFR1, 2, and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC)

Author

Bhargava, P., primary, Esteves, B., additional, Nosov, D. A., additional, Lipatov, O. N., additional, Lyulko, A. A., additional, Anischenko, A. A., additional, Chacko, R. T., additional, Lee, P., additional, Al-Adhami, M., additional, and Ryan, J., additional

Published
2009
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39. Impact of an outpatient interdisciplinary team (IDT) consultation on symptom clusters in advanced cancer patients seen at a supportive care outpatient clinic (OSC) in a tertiary cancer center

Author

Yennurajalingam, S., primary, Urbauer, D. L., additional, Chacko, R., additional, Hui, D., additional, Amin, Y. A., additional, Evans, A. C., additional, Orihuela, C., additional, Casper, K. L., additional, Poulter, V., additional, Coldman, B., additional, and Bruera, E., additional

Published
2009
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44. A phase II study of sequential neoadjuvant gemcitabine plus doxorubicin followed by gemcitabine plus cisplatin in patients with operable breast cancer: prediction of response using molecular profiling

Author

Julka, P K, primary, Chacko, R T, additional, Nag, S, additional, Parshad, R, additional, Nair, A, additional, Oh, D S, additional, Hu, Z, additional, Koppiker, C B, additional, Nair, S, additional, Dawar, R, additional, Dhindsa, N, additional, Miller, I D, additional, Ma, D, additional, Lin, B, additional, Awasthy, B, additional, and Perou, C M, additional

Published
2008
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46. Variability of fronts, fresh water input and chlorophyll in the Indian Ocean sector of the Southern Ocean.

Author

Anilkumar, N, George, JV, Chacko, R, Nuncio, N, and Sabu, P

Subjects
FRESH water, CHLOROPHYLL, MELTWATER, ANTARCTIC Circumpolar Current
Abstract

The aim of this study was to understand the variability in the fronts and water masses, and the effect of melt water on the concentration of chlorophyll (Chla) in the Indian Ocean sector of the Southern Ocean using hydrographic data collected during the austral summer (February 2010 and 2011). The Southern Subtropical Front (SSTF) and Northern Sub Antarctic Front (SAF1) were found to be further south at 57°30′E than at 47–48°E. This southward shift of the fronts was consistent with the southward meandering (c. 2°) of the Antarctic Circumpolar Current (ACC) core from the western section to the eastern section, which could have been caused by the bottom topography. The intrusion of water masses also differed between the western and eastern transects of the study region as a result of the meandering of the ACC core. Fresh water layer thickness relative to the winter water in 2011 was more compared to that during 2010. This could have been due to the larger amount of sea ice that was present in the winter of 2010, which subsequently melted, resulting in the advection of melt water from the south and west of the study region. In situ observations and satellite data detected a high Chlaconcentration (c. 0.38 mg m−3) south of the Northern Polar Front (PF1) in 2011, which was caused by this melt water. [ABSTRACT FROM AUTHOR]

Published
2015
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47. Understanding thalidomide-associated deep vein thrombosis/pulmonary emboli (DVT/PE): Comparison of quality and information included in adverse event reports from clinical trials, clinical practice, STEPS, and the medical literature

Author

Singh, V., primary, Klinge, S. A., additional, Luminari, S., additional, Belknap, S. M., additional, Raisch, D. W., additional, Yarnold, P. R., additional, Kim, B., additional, Chacko, R., additional, Tallman, M. S., additional, and Bennett, C. L., additional

Published
2004
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48. Gemtuzumab ozogamicin (GO)-associated veno-occlusive disease (VOD): An analysis of adverse drug reaction (ADR) reports in the clinical trials, clinical practice, and in the medical literature

Author

Klinge, S. A., primary, Chacko, R., additional, Bennett, C. L., additional, Luminari, S., additional, Lyons, E. A., additional, Trifilio, S., additional, McKoy, J., additional, Yarnold, P. R., additional, Raisch, D. W., additional, and Tallman, M. S., additional

Published
2004
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