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An animal model of tubal sterilisation would be valuable in order to examine the problem of severe damage of the tubal wall and to study the criteria for optimal anastomosis. In a preliminary experimental group the Fallopian tubes of 30 rabbits were ligated at the isthmic segment. Specimens of the ligated portion and other tubal segments have been investigated by light microscopy and scanning and transmission electronmicroscopy one, four and twelve weeks following the ligature. Changes in the Fallopian tubes following the ligature were limited to the ligated portion. The morphological findings consisted of a flattening and decrease of differentiation of the mucous epithelium, and of a slight scarring in the tubal wall and in the subperitoneal tissue within the constricted segment. Tubal ligation at the isthmic segment provides good conditions for refertilisation, following resection of the altered portion and microsurgical anastomosis.

Using microsurgical techniques and two layers of sutures, we reanastomosed 66 rabbit oviducts; 35 had been divided in the isthmic region and 31 in the ampullary region. With light microscopy as well as transmission and scanning electron microscopy we studied anastomosed segments and the rest of the oviducts 1 day, 1 week, and 4--12 weeks after operation. -- In the vicinity of the sutures we found slight scarring, some flattening of the mucosal epithelium with loss of differentiation and, most important, displacement of the mucosa into the muscle wall of the tube with the development of irregular diverticuli. The significance of these alterations and their possible relation to the occurrence of tubal ectopic pregnancy is discussed. We recommend that care should be taken to avoid the mucosa during total anastomosis.

Die Reizblase ist gegenuber einer reinen Stres-Inkontinenz bei negativem urologischen Befund durch eine Hyperaktivitat des Detrusors vesicae gekennzeichnet. Am haufigsten ist die Blasendysfunktion Teilsyndrom einer psychovegetativen Storung. Der Gynakologe sieht vor allem Patientinnen mit Blasenhypertonus unnd Inkontinenzbeschwerden. Mittels der Urethro-Cysto-Tonometrie ist eine Abgrenzung gegenuber der Stres-Inkontinenz moglich. Dies ist fur das therapeutische Vorgehen von entscheidender Bedeutung.

An animal model of tubal sterilization would be valuable to examine the problem of tubal wall damages and to study the criteria for optimal anastomosis.