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Objective Among specific autoantibodies in DM, the anti–small ubiquitin-like modifier activating enzyme (SAE) antibody is rare. We aim to describe the clinical characteristics, cancer prevalence, and muscle pathology of anti-SAE–positive DM. Methods Patients with a diagnosis of DM and sera positive for the anti-SAE antibody were recruited from 19 centres in this retrospective observational study. The available muscular biopsies were reviewed. We conducted a comparison with anti-SAE–negative DM and a review of the literature. Results Of the patients in the study (n  = 49), 84% were women. Skin involvement was typical in 96% of patients, with 10% having calcinosis, 18% ulceration and 12% necrosis; 35% presented with a widespread skin rash. Muscular disease affected 84% of patients, with mild weakness [Medical Research Council (MRC) scale 4 (3, 5)], although 39% of patients had dysphagia. Muscular biopsies showed typical DM lesions. Interstitial lung disease was found in 21% of patients, mainly with organizing pneumonia pattern, and 26% of patients showed dyspnoea. Cancer-associated myositis was diagnosed in 16% of patients and was responsible for the majority of deaths, its prevalence being five times that of the general population. IVIG therapy was administered to 51% of the patients during the course of the disease. Comparison with anti-SAE–negative DM (n  = 85) showed less and milder muscle weakness (P  = 0.02 and P  = 0.006, respectively), lower creatinine kinase levels (P  < 0.0001) and less dyspnoea (P  = 0.003). Conclusion Anti-SAE positive DM is a rare subgroup associated with typical skin features but a potentially diffuse rash, a mild myopathy. Interstitial lung disease defines an organizing pneumonia pattern. Cancer associated DM prevalence is five times that of the general population. Trial registration ClinicalTrials.gov, http://clinicaltrials.gov , NCT04637672. [ABSTRACT FROM AUTHOR]

The right eyebrow nodule was surgically removed, and the anatomopathological examination was identical to the previous one; mycobacteriological culture was negative whereas I Cutibacterium acnes i was isolated on bacteriological cultures. Anatomopathological examination of the forehead lesion disclosed multiple epithelioid and giant-cell granulomas with central necrosis and Langhans giant cells in the dermis layer (Fig. Dear Editor, A 75-year-old woman with a negative medical history was admitted to the hospital for a nodule of the glabella, then of the right eyebrow arch, mandible, and preauricular area (Fig. [Extracted from the article]

We present a case of atopic nipple eczema leading to reactive hyperprolactinemia, by mechanical nipple stimulation. This reactive hyperprolactinemia caused an aggravation of the eczema because of the resulting galactorrhea, by local irritation and inflammation, and was complicated by a galactocele. This benign tumour was a source of concern for the patient and required several diagnostic radiographic examinations. [ABSTRACT FROM AUTHOR]