Search

Your search keyword '"Cesaro Flavio"' showing total 24 results
Start Over Author "Cesaro Flavio"
24 results on '"Cesaro Flavio"'

1. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis

Author

Roberto Cangemi, Valeria Raparelli, Giovanni Talerico, Stefania Basili, Francesco Violi, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davì Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Corazza Gino Roberto, Caldwell Stephen Hugh, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Proietti Marco, Raparelli Valeria, Romiti Giulio Francesco, Ruscio Eleonora, Severoni Andrea, Talerico Giovanni, Toriello Filippo, and Vestri Annarita

Subjects
Albumin, Cirrhosis, Portal Vein Thrombosis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and Aims: Hypoalbuminemia, as defined by serum albumin (SA) levels ≤35 g/L, is associated to venous and arterial thrombosis in general population and in patients at risk of cardiovascular disease. It is unknown if SA ≤35 g/L is also associated to portal vein thrombosis (PVT) in cirrhosis. Methods: Cirrhotic patients enrolled in the Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry (PRO-LIVER) study (n = 753), were followed-up for 2 years to assess the risk of PVT, that was diagnosed by Doppler ultrasonography. Child-Pugh classes, Model for End-Stage Liver Disease score, presence of hepatocellular carcinoma and laboratory variables including SA, D-dimer, and high-sensitivity C-reactive protein (hs-CRP) were measured at baseline. Results: SA ≤35 g/L was detected in 52% of patients. A logistic multivariate regression analysis showed that higher Child-Pugh class, hepatocellular carcinoma and thrombocytopenia were significantly associated to SA ≤35 g/L. In a subgroup of patients where data regarding hs-CRP and D-dimer were available, SA ≤35 g/L was inversely associated with hs-CRP and D-dimer. During the follow-up, a total of 61 patients experienced PVT. A Kaplan Meier survival analysis showed SA ≤35 g/L was associated to increased risk of PVT compared to SA >35 g/L (P = .005). A multivariate Cox proportional hazards regression analysis showed that male sex, lower platelet count, and SA ≤35 g/L remained associated to PVT after adjusting for confounding factors. Conclusion: Cirrhotic patients with SA ≤35 g/L are at higher risk of experiencing PVT compared to those with SA >35 g/L and could be considered as potential candidates to anticoagulant prophylaxis for PVT prevention.

Published
2024
Full Text
View/download PDF

5. Brain and heart in Emergency Department

Author

CARELLI, Claudia, primary, CESARO, Flavio, additional, CIMMINO, Claudia S., additional, DE VITA, Alessio, additional, ERCOLANO, Erica, additional, GIACONIA, Gianluca, additional, MANZO, Carmela, additional, PAUDICE, Francesca, additional, RONGA, Bruno, additional, SENESE, Alessandra, additional, and GUARINO, Mario, additional

Published
2023
Full Text
View/download PDF

11. Endobronchial hamartoma in a young COVID-19 symptomatic woman. Radical endoscopic treatment with a disposable bronchoscope. Case Report

Author

Guarino, Carmine, primary, Cesaro, Cristiano, additional, La Cerra, Giuseppe, additional, Lucci, Raffaella, additional, Cesaro, Flavio, additional, Zamparelli, Enzo, additional, Gaglione, Gianfranco, additional, Pontarelli, Agostina, additional, De Rosa, Annunziata, additional, and Parrella, Roberto, additional

Published
2021
Full Text
View/download PDF

14. Alectinib rescue therapy in advanced ALK rearranged lung adenocarcinoma: a case report.

Author

Cesaro, Cristiano, Caterino, Umberto, Perrotta, Fabio, Masi, Umberto, Cotroneo, Alessandra, Cianci, Roberta, Zamparelli, Enzo, Cesaro, Flavio, Amore, Dario, and Rocco, Danilo

Subjects
PLEURAL effusions, ANAPLASTIC lymphoma kinase, NON-small-cell lung carcinoma, ADENOCARCINOMA, PROTEIN-tyrosine kinase inhibitors, LUNGS
Abstract

Alectinib is a highly selective tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) that is approved as first-line treatment in adult patients with ALK-positive non-small cell lung cancer (NSCLC) and as second-line in patients previously treated with crizotinib, and has been shown in the literature to significantly prolong progression-free survival compared to chemotherapy in patients with advanced non-small cell lung cancer. The authors describe a clinical case of a 24-year-old woman with malignant massive pleural effusion caused by ALK rearranged pulmonary adenocarcinoma with pleural and pericardial metastasis, in which, despite a dramatic clinical debut, the correct and timely management of the diagnostic and therapeutic path allowed for extraordinary therapeutic success. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

16. Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

Author

Basili, Stefania, Carnevale, Roberto, Nocella, Cristina, Bartimoccia, Simona, Raparelli, Valeria, Talerico, Giovanni, Stefanini, Lucia, Romiti, Giulio F, Perticone, Francesco, Corazza, Gino R, Piscaglia, Fabio, Pietrangelo, Antonello, Violi, Francesco, and PRO-LIVER collaborators, : Ainora Maria Elena, Andreozzi, Paola, Andriulli, Angelo, Angelico, Francesco, Angelico, Mario, Figliomeni, Antonio, Anzaldi, Massimiliano, Arena, Umberto, Averna, Maurizio, Barone, Milena, Bazzini, Cristina, Bergamaschi, Gaetano, Bertoni, Michele, Bianchi Giovanni Battista, Bianchi Paola Ilaria, Boari, Benedetta, Bombonato, Giancarlo, Bracco, Christian, Brocco, Silvia, Buonauro, Agostino, Buttà, Carmelo, Buzzetti, Elena, Cacciola, Irene, Calabria, Stefano, Cangemi, Roberto, Capeci, William, Caradio, Federica, Carderi, Isabella, Carleo, Pietro, Caroleo, Benedetto, Carrabba Maria Domenica, Castorani, Luigi, Cavallo, Maurizio, Cecchetto, Lara, Cesaro, Flavio, Cicco, Sebastiano, Cimini, Claudia, Colombo Barbara Maria, Corradini, Elena, Corrao, Salvatore, Costantino, Giorgio, Costanzo, Filippo, Croce, Giuseppe, Cuoghi, Chiara, Curigliano, Valentina, D’Alitto, Felicia, D’Amico, Gennaro, De Franchis Roberto, De Giorgi Alfredo, De Vuono Stefano, Debernardi Venon Wilma, Del Ben Maria, Del Corso Lisette, Delitala, Giuseppe, Denegri, Andrea, Di Cesare Valentina, Di Giosia Paolo, Di Michele Dario, Di Minno Giovanni, Donnarumma, Emilia, Drenaggi, Davide, Durante-Mangoni, Emanuele, Falsetti, Lorenzo, Farcomeni, Alessio, Farinaro, Vincenza, Fasolato, Silvano, Ferrari, Giovanni, Fierro, Tiziana, Forgione, Alessandra, Frugiuele, Pierluigi, Galati, Giovanni, Gallo, Paolo, Garcovich, Matteo, Gargano, Ruggiero, Gasbarrini, Antonio, Gatta, Angelo, Giammanco, Antonina, Giannelli, Gianluigi, Giorgini, Paolo, Gobbi, Paolo, Granito, Alessandro, Grassi, Davide, Greco, Antonio, Grembiale, Alessandro, Gresele, Paolo, Hijazi, Daniel, Iacobellis, Angelo, Iamele, Luigi, Invernizzi, Pietro, Ippolito, Antonio, Laffi, Giacomo, Licata, Anna, Liguori Maria Livia, Lorusso, Giusi, Maimone, Sergio, Manfredini, Roberto, Marcacci, Matteo, Marchese, Alessandra, Marinelli, Sara, Marra Alberto Maria, Martino Giuseppe Pio, Masala, Maristella, Masotti, Michela, Merla, Antonio, Miceli, Giuseppe, Montebianco Abenavoli Ludovico, Morana, Ignazio, Morelli, Olivia, Murgia, Giuseppe, Naccarato, Paola, Neri, Sergio, Niro, Grazia, Nobili, Lorenzo, Padula, Donatella, Palasciano, Giuseppe, Palmieri Vincenzo Ostilio, Pastori, Daniele, Pattoneri, Paolo, Perego, Francesca, Perticone, Maria, Pesce, Paola, Petramala, Luigi, Pettinari, Irene, Piano, Salvatore, Picardi, Antonio, Pignataro Francesca Serena, Pignataro, Pietro, Pignatelli, Pasquale, Pinna, Miriam, Pinto, Antonio, Pinto, Daniela, Polimeni, Licia, Pretti, Vincenzo, Privitera, Graziella, Proietti, Marco, Pucci, Giacomo, Purrello, Francesco, Ragone, Enrico, Raimondo, Giovanni, Restuccia, Tea, Riccardi, Laura, Rizzetto, Mario, Rodríguez-Castro Kryssia Isabel, Romanelli Roberto Giulio, Ruscio, Eleonora, Sacerdoti, David, Salinaro, Francesco, Salvi, Aldo, Salzano, Andrea, Santangelo, Giuseppe, Santarossa, Claudia, Santilli, Francesca, Santovito, Daniela, Scarpini, Francesca, Schiavone, Cosima, Scicali, Roberto, Senzolo, Marco, Serra, Carla, Serviddio, Gaetano, Sirico, Domenico, Soresi, Maurizio, Sperduti, Nicolò, Staffolani, Silvia, Staltari, Orietta, Stasi, Cristina, Suppressa, Patrizia, Svegliati Baroni Gianluca, Talia, Michela, Tana, Claudio, Tassone Eliezer Joseph, Todisco, Tommaso, Toriello, Filippo, Torres, Daniele, Traversa, Matteo, Tripepi, Giovanni, Tufano, Antonella, Tuttolomondo, Antonino, Varvara, Doriana, Vazzana, Natale, Vecchio Claudia Rita, Vendemiale, Gianluigi, Ventura, Paolo, Vespasiani-Gentilucci, Umberto, Vettore, Elia, Vidili, Gianpaolo, Villani, Rosanna, Vincenzo, Ronca, Visioli, Giacomo, Vitale, Francesco, Zocco Maria, Assunta., and Stefania Basili, Roberto Carnevale, Cristina Nocella, Simona Bartimoccia, Valeria Raparelli, Giovanni Talerico, Lucia Stefanini, Giulio F. Romiti, Francesco Perticone, Gino R. Corazza, Fabio Piscaglia, Antonello Pietrangelo, Francesco Violi, PRO-LIVER Collaborators, Alessandro Granito

Subjects
medicine.medical_specialty, Cirrhosis, Isoprostane, Urinary system, serum albumin, Serum albumin, Gastroenterology, NO, chemistry.chemical_compound, Internal medicine, Medicine, Platelet, portal vein thrombosis, Platelet activation, Portal vein thrombosis, Albumin, risk, protein, albumin, risk, Hepatology, biology, business.industry, cirrhosis, Albumin, Original Articles, medicine.disease, Portal vein thrombosis, chemistry, biology.protein, Original Article, protein, albumin, portal vein thrombosis, cirrhosis, business
Abstract

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound‐detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross‐sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, −0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40‐ligand (P = 0.0238), soluble Nox2‐derived peptide (sNox2‐dp; P < 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD40L (Spearman’s rank correlation coefficient [rs], −0.33; P < 0.001), sNox2‐dp (rs, −0.57; P < 0.0001), and urinary excretion of isoprostanes (rs, −0.48; P < 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2‐dp, and urinary 8‐iso prostaglandin F2α‐III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2‐dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation.

Published
2019

17. Endobronchial hamartoma in a young COVID-19 symptomatic woman. Radical endoscopic treatment with a disposable bronchoscope. Case Report.

Author

Guarino, Carmine, Cesaro, Cristiano, La Cerra, Giuseppe, Lucci, Raffaella, Cesaro, Flavio, Zamparelli, Enzo, Gaglione, Gianfranco, Pontarelli, Agostina, De Rosa, Annunziata, and Parrella, Roberto

Subjects
HAMARTOMA, COVID-19, VIRAL transmission, LUNG tumors, COMPUTED tomography, BENIGN tumors
Abstract

Pulmonary hamartomas represent the most frequent family of benign lung tumors that typically involve the lung parenchyma and only rarely grow as endobronchial tumors. The elective treatment of endobronchial hamartoma is the bronchoscopic resection, and in those cases in which tumor extension and localization makes it not possible, surgical treatment must be evaluated. Patients with symptomatic COVID-19, hospitalized, frequently undergo a chest CT scan and in some cases, occasional findings may emerge, requiring diagnostic investigations such as bronchoscopy and interventional pulmonology procedures. Therefore, in such a delicate pathological condition, such as COVID-19, the need to perform bronchoscopy and interventional pulmonology procedures, minimizing the risk of viral transmission and ensuring necessary assistance, represents a great challenge for pulmonologists. In this article authors describe, for the first time in literature, a rare case of endobronchial hamartoma, radically resected using a single use bronchoscope, in a young female patient hospitalized for symptomatic COVID-19. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

18. Erratum to: Portal vein thrombosis relevance on liver cirrhosis: Italian Venous Thrombotic Events Registry (Intern Emerg Med, 10.1007/s11739-016-1416-8)

Author

Violi F., Corazza G. R., Caldwell S. H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., PRO-LIVER Collaborators Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davı` Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodrıguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Raparelli Valeria, Talerico Giovanni, Proietti Marco, Romiti Giulio Francesco, Ruscio Eleonora, Toriello Filippo, Violi F., Corazza G.R., Caldwell S.H., Perticone F., Gatta A., Angelico M., Farcomeni A., Masotti M., Napoleone L., Vestri A., Raparelli V., Basili S., and PRO-LIVER Collaborators Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davı` Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodrıguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Raparelli Valeria, Talerico Giovanni, Proietti Marco, Romiti Giulio Francesco, Ruscio Eleonora, Toriello Filippo

Subjects
Splanchnic venous thrombosis Anticoagulants Liver failure Hepatocellular carcinoma Esophageal varices
Abstract

In the original publication, the second author name was incorrectly published as Roberto Gino Corazza. The correct name should read as “Gino Roberto Corazza”. Also, the PRO-LIVER Study Collaborator, Dr. Gabriella Carnevale Maffè has not been included in the Appendix by mistake. The name of Dr. Carnevale Maffe` should read in the Appendix as follows: Bergamaschi Gaetano, Carnevale Maffè Gabriella, Masotti Michela, Costanzo Filippo (I° Clinica Medica, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy).

Published
2016

19. Platelet count does not predict bleeding in cirrhotic patients: Results from the PRO-LIVER Study

Author

Basili, S. a, Raparelli, V. b., Napoleone, L. b., Talerico, G. a., Corazza, G. R. c., Perticone, F. d., Sacerdoti, D. e., Andriulli, A. f., Licata, A. g., Pietrangelo, A., Picardi, A. i., Raimondo, G. j., Violi, F., Palasciano, G., D’Alitto, F., Palmieri, V. O., Santovito, D., Michele, Di, Croce, D., Brocco, G., Fasolato, S., Cecchetto, S., Bombonato, L., Bertoni, G., Restuccia, M., Andreozzi, T., Liguori, P., Caroleo, M. L., Perticone, B., Staltari, M., Manfredini, O., Giorgi, De, Averna, A., Giammanco, M., Granito, A., Pettinari, A., Marinelli, I., Bolondi, S., Falsetti, L., Salvi, L., Durante-Mangoni, A., Cesaro, E., Farinaro, F., Ragone, V., Morana, E., Ippolito, I., Iacobellis, A., Niro, A., Merla, G., Maimone, A., Cacciola, S., Varvara, I., Drenaggi, D., Staffolani, D., Vespasiani-Gentilucci, S., Galati, U., Gallo, G., Davì, P., Schiavone, G., Santilli, C., Tana, F., Soresi, C., Bianchi, Giovanni, Carderi, B., Pinto, I., Tuttolomondo, A., Ferrari, A., Gresele, G., Fierro, P., Morelli, T., Laffi, O., Romanelli, G., Arena, R. G., Stasi, U., Gasbarrini, A., Garcovich, M., Zocco, M. A., Riccardi, L., Ainora, M. E., Capeci, W., Martino, Giuseppe, Nobili, P., Cavallo, L., Frugiuele, M., Greco, P., Ventura, P., Cuoghi, C., Marcacci, M., Serviddio, G., Vendemiale, G., Villani, R., Gargano, R., Vidili, G., Cesare, Di, Masala, V., Delitala, M., Invernizzi, G., Vincenzo, P., Minno, Di, Tufano, G., Purrello, A., Privitera, F., Forgione, G., Curigliano, A., Senzolo, V., Rodríguez-Castro, M., Giannelli, K. I., Serra, G., Neri, C., Pignataro, S., Rizzetto, P., Debernardi, M., Svegliati, V. W., Bergamaschi, B. G., Masotti, G., Costanzo, M., Antonio, F., Angelico, F., Del, Ben, Polimeni, M., Proietti, L., Cangemi, M., Romiti, R., Toriello, G. F., Sperduti, F., Santangelo, N., Visioli, G., Todisco, G., Vestri, Anna, Farcomeni, R., Corrao, A., Gobbi, S., Corradini, E., Costantino, G., Tripepi, G., Angelico, M., Bolondi, L., D’Amico, G., Franchis, De, Gatta, R., Tassone, A., Anzaldi, E. J., Barone, M., Bazzini, M., Bianchi, C., Boari, P. I., Bracco, B., Buonauro, C., Buttà, A., Buzzetti, E., Calabria, S., Caradio, F., Carleo, P., Carrabba, Maria, Castorani, D., Cecchetto, L., Cicco, L., Cimini, S., Colombo, C., B. M., Vuono, De, Denegri, S., Del, Corso, Giosia, Di, Donnarumma, P., Giorgini, E., Grassi, P., Grembiale, D., Hijazi, A., Iamele, D., Lorusso, L., Marchese, G., Marra, Alberto, Masala, M., Miceli, M., Montebianco, G., Murgia, A. L., Naccarato, G., Padula, P., Pattoneri, D., Perego, P., Pesce, F., Petramala, P., Piano, L., Pinto, S., Pinna, D., Pignataro, M., Pretti, F. S., Pucci, V., Salinaro, G., Salzano, F., Santarossa, A., Scarpini, C., Scicali, F., Sirico, R., Suppressa, D., Talia, P., Torres, M., Traversa, D., Vazzana, M., Vecchio, Claudia, Vettore, R., Vitale, E., Basili, S., Raparelli, V., Napoleone, L., Talerico, G., Corazza, G.R., Perticone, F., Sacerdoti, D., Andriulli, A., Licata, A., Pietrangelo, A., Picardi, A., Raimondo, G., Violi, F., Palasciano, Giuseppe, D’Alitto, Felicia, Palmieri, Vincenzo Ostilio, Santovito, Daniela, Di Michele, Dario, Croce, Giuseppe, Brocco, Silvia, Fasolato, Silvano, Cecchetto, Lara, Bombonato, Giancarlo, Bertoni, Michele, Restuccia, Tea, Andreozzi, Paola, Liguori, Maria Livia, Caroleo, Benedetto, Perticone, Maria, Staltari, Orietta, Manfredini, Roberto, De Giorgi, Alfredo, Averna, Maurizio, Giammanco, Antonina, Granito, Alessandro, Pettinari, Irene, Marinelli, Sara, Bolondi, Luigi, Falsetti, Lorenzo, Salvi, Aldo, Durante-Mangoni, Emanuele, Cesaro, Flavio, Farinaro, Vincenza, Ragone, Enrico, Morana, Ignazio, Ippolito, Antonio, Iacobellis, Angelo, Niro, Grazia, Merla, Antonio, Maimone, Sergio, Cacciola, Irene, Varvara, Doriana, Drenaggi, Davide, Staffolani, Silvia, Vespasiani-Gentilucci, Umberto, Galati, Giovanni, Gallo, Paolo, Davì, Giovanni, Schiavone, Cosima, Santilli, Francesca, Tana, Claudio, Soresi, Maurizio, Bianchi Giovanni, Battista, Carderi, Isabella, Pinto, Antonio, Tuttolomondo, Antonino, Ferrari, Giovanni, Gresele, Paolo, Fierro, Tiziana, Morelli, Olivia, Laffi, Giacomo, Romanelli, Roberto Giulio, Arena, Umberto, Stasi, Cristina, Gasbarrini, Antonio, Garcovich, Matteo, Zocco, Maria Assunta, Riccardi, Laura, Ainora, Maria Elena, Capeci, William, Martino Giuseppe, Pio, Nobili, Lorenzo, Cavallo, Maurizio, Frugiuele, Pierluigi, Greco, Antonio, Ventura, Paolo, Cuoghi, Chiara, Marcacci, Matteo, Serviddio, Gaetano, Vendemiale, Gianluigi, Villani, Rosanna, Gargano, Ruggiero, Vidili, Gianpaolo, Di Cesare, Valentina, Masala, Maristella, Delitala, Giuseppe, Invernizzi, Pietro, Vincenzo, Ronca, Di Minno, Giovanni, Tufano, Antonella, Purrello, Francesco, Privitera, Graziella, Forgione, Alessandra, Curigliano, Valentina, Senzolo, Marco, Rodríguez-Castro, Kryssia Isabel, Giannelli, Gianluigi, Serra, Carla, Neri, Sergio, Pignataro, Pietro, Rizzetto, Mario, Debernardi, Venon Wilma, Svegliati, Baroni Gianluca, Bergamaschi, Gaetano, Masotti, Michela, Costanzo, Filippo, Antonio, Figliomeni, Angelico, Francesco, Del Ben, Maria, Polimeni, Licia, Proietti, Marco, Cangemi, Roberto, Romiti Giulio, Francesco, Toriello, Filippo, Sperduti, Nicolò, Santangelo, Giuseppe, Visioli, Giacomo, Todisco, Tommaso, Vestri Anna, Rita, Farcomeni, Alessio, Corrao, Salvatore, Gobbi, Paolo, Corradini, Elena, Costantino, Giorgio, Tripepi, Giovanni, Angelico, Mario, D’Amico, Gennaro, De Franchis, Roberto, Gatta, Angelo, Tassone, Eliezer Joseph, Anzaldi, Massimiliano, Barone, Milena, Bazzini, Cristina, Bianchi, Paola Ilaria, Boari, Benedetta, Bracco, Christian, Buonauro, Agostino, Buttà, Carmelo, Buzzetti, Elena, Calabria, Stefano, Caradio, Federica, Carleo, Pietro, Carrabba Maria, Domenica, Castorani, Luigi, Cicco, Sebastiano, Cimini, Claudia, Colombo, Barbara Maria, De Vuono, Stefano, Denegri, Andrea, Del Corso, Lisette, Di Giosia, Paolo, Donnarumma, Emilia, Giorgini, Paolo, Grassi, Davide, Grembiale, Alessandro, Hijazi, Daniel, Iamele, Luigi, Lorusso, Giusi, Marchese, Alessandra, Marra Alberto, Maria, Miceli, Giuseppe, Montebianco, Abenavoli Ludovico, Murgia, Giuseppe, Naccarato, Paola, Padula, Donatella, Pattoneri, Paolo, Perego, Francesca, Pesce, Paola, Petramala, Luigi, Piano, Salvatore, Pinto, Daniela, Pinna, Miriam, Pignataro, Francesca Serena, Pretti, Vincenzo, Pucci, Giacomo, Salinaro, Francesco, Salzano, Andrea, Santarossa, Claudia, Scarpini, Francesca, Scicali, Roberto, Sirico, Domenico, Suppressa, Patrizia, Talia, Michela, Torres, Daniele, Traversa, Matteo, Vazzana, Natale, Vecchio Claudia, Rita, Vettore, Elia, Vitale, Francesco, Basili, S, Raparelli, V, Napoleone, L, Talerico, G, Corazza, G, Perticone, F, Sacerdoti, D, Andriulli, A, Licata, A, Pietrangelo, A, Picardi, A, Raimondo, G, Violi, F, Palasciano, G, D'Alitto, F, Palmieri, V, Santovito, D, Di Michele, D, Croce, G, Brocco, S, Fasolato, S, Cecchetto, L, Bombonato, G, Bertoni, M, Restuccia, T, Andreozzi, P, Liguori, M, Caroleo, B, Perticone, M, Staltari, O, Manfredini, R, De Giorgi, A, Averna, M, Giammanco, A, Granito, A, Pettinari, I, Marinelli, S, Bolondi, L, Falsetti, L, Salvi, A, Durante-Mangoni, E, Cesaro, F, Farinaro, V, Ragone, E, Morana, I, Ippolito, A, Iacobellis, A, Niro, G, Merla, A, Maimone, S, Cacciola, I, Varvara, D, Drenaggi, D, Staffolani, S, Vespasiani-Gentilucci, U, Galati, G, Gallo, P, Davi, G, Schiavone, C, Santilli, F, Tana, C, Soresi, M, Bianchi Giovanni, B, Carderi, I, Pinto, A, Tuttolomondo, A, Ferrari, G, Gresele, P, Fierro, T, Morelli, O, Laffi, G, Romanelli, R, Arena, U, Stasi, C, Gasbarrini, A, Garcovich, M, Zocco, M, Riccardi, L, Ainora, M, Capeci, W, Martino Giuseppe, P, Nobili, L, Cavallo, M, Frugiuele, P, Greco, A, Ventura, P, Cuoghi, C, Marcacci, M, Serviddio, G, Vendemiale, G, Villani, R, Gargano, R, Vidili, G, Di Cesare, V, Masala, M, Delitala, G, Invernizzi, P, Vincenzo, R, Di Minno, G, Tufano, A, Purrello, F, Privitera, G, Forgione, A, Curigliano, V, Senzolo, M, Rodriguez-Castro, K, Giannelli, G, Serra, C, Neri, S, Pignataro, P, Rizzetto, M, Debernardi, V, Svegliati, B, Bergamaschi, G, Masotti, M, Costanzo, F, Antonio, F, Angelico, F, Del Ben, M, Polimeni, L, Proietti, M, Cangemi, R, Romiti, G, Toriello, F, Sperduti, N, Santangelo, G, Visioli, G, Todisco, T, Vestri Anna, R, Farcomeni, A, Corrao, S, Gobbi, P, Corradini, E, Costantino, G, Tripepi, G, Angelico, M, D'Amico, G, De Franchis, R, Gatta, A, Tassone, E, Anzaldi, M, Barone, M, Bazzini, C, Bianchi, P, Boari, B, Bracco, C, Buonauro, A, Butta, C, Buzzetti, E, Calabria, S, Caradio, F, Carleo, P, Carrabba Maria, D, Castorani, L, Cicco, S, Cimini, C, Colombo, B, De Vuono, S, Denegri, A, Del Corso, L, Di Giosia, P, Donnarumma, E, Giorgini, P, Grassi, D, Grembiale, A, Hijazi, D, Iamele, L, Lorusso, G, Marchese, A, Marra, A, Miceli, G, Montebianco, A, Murgia, G, Naccarato, P, Padula, D, Pattoneri, P, Perego, F, Pesce, P, Petramala, L, Piano, S, Pinto, D, Pinna, M, Pignataro, F, Pretti, V, Pucci, G, Salinaro, F, Salzano, A, Santarossa, C, Scarpini, F, Scicali, R, Sirico, D, Suppressa, P, Talia, M, Torres, D, Traversa, M, Vazzana, N, Vecchio Claudia, R, Vettore, E, Vitale, F, S Basili, V Raparelli, L Napoleone, G Talerico, G Corazza, F Perticone, D Sacerdoti, A Andriulli, A Licata, A Pietrangelo, A Picardi, G Raimondo, F Violi, MD on behalf of PRO-LIVER Collaborator, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davi Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Garcovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Vincenzo Ronca, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Antonio Figliomeni, Angelico Francesco, Del Ben Maria, Polimeni Licia, Proietti Marco, Cangemi Roberto, Romiti Giulio Francesco, Toriello Filippo, Sperduti Nicolò, Santangelo Giuseppe, Visioli Giacomo, Todisco Tommaso, Vestri Anna Rita, Farcomeni Alessio, Corrao Salvatore, Gobbi Paolo, Corradini Elena, Costantino Giorgio, Tripepi Giovanni, Angelico Mario, D’Amico Gennaro, de Franchis Roberto, Gatta Angelo, Tassone Eliezer Joseph, Anzaldi Massimiliano, Barone Milena, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Bracco Christian, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Calabria Stefano, Caradio Federica, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cicco Sebastiano, Cimini Claudia, Colombo Barbara Maria, De Vuono Stefano, Denegri Andrea, Del Corso Lisette, Di Giosia Paolo, Donnarumma Emilia, Giorgini Paolo, Grassi Davide, Grembiale Alessandro, Hijazi Daniel, Iamele Luigi, Lorusso Giusi, Marchese Alessandra, Marra Alberto Maria, Miceli Giuseppe, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Padula Donatella, Pattoneri Paolo, Perego Francesca, Pesce Paola, Petramala Luigi, Piano Salvatore, Pinto Daniela, Pinna Miriam, Pignataro Francesca Serena, Pretti Vincenzo, Pucci Giacomo, Salinaro Francesco, Salzano Andrea, Santarossa Claudia, Scarpini Francesca, Scicali Roberto, Sirico Domenico, Suppressa Patrizia, Talia Michela, Torres Daniele, Traversa Matteo, Vazzana Natale, Vecchio Claudia Rita, Vettore Elia, Vitale Francesco, Corazza, G. R., Guidacci, Raimondo, Palasciano, G., D'Alitto, F., Palmieri, V. O., Santovito, D., Di Michele, D., Croce, G., Brocco, S., Fasolato, S., Cecchetto, L., Bombonato, G., Bertoni, M., Restuccia, T., Andreozzi, P., Liguori, M. L., Caroleo, B., Perticone, M., Staltari, O., Manfredini, R., De Giorgi, A., Averna, M., Giammanco, A., Granito, A., Pettinari, I., Marinelli, S., Bolondi, L., Falsetti, L., Salvi, A., Durante-Mangoni, E., Cesaro, F., Farinaro, V., Ragone, E., Morana, I., Ippolito, A., Iacobellis, A., Niro, G., Merla, A., Maimone, S., Cacciola, I., Varvara, D., Drenaggi, D., Staffolani, S., Vespasiani-Gentilucci, U., Galati, G., Gallo, P., Davi, G., Schiavone, C., Santilli, F., Tana, C., Soresi, M., Bianchi Giovanni, B., Carderi, I., Pinto, A., Tuttolomondo, A., Ferrari, G., Gresele, P., Fierro, T., Morelli, O., Laffi, G., Romanelli, R. G., Arena, U., Stasi, C., Gasbarrini, A., Garcovich, M., Zocco, M. A., Riccardi, L., Ainora, M. E., Capeci, W., Martino Giuseppe, P., Nobili, L., Cavallo, M., Frugiuele, P., Greco, A., Ventura, P., Cuoghi, C., Marcacci, M., Serviddio, G., Vendemiale, G., Villani, R., Gargano, R., Vidili, G., Di Cesare, V., Masala, M., Delitala, G., Invernizzi, P., Vincenzo, R., Di Minno, G., Tufano, A., Purrello, F., Privitera, G., Forgione, A., Curigliano, V., Senzolo, M., Rodriguez-Castro, K. I., Giannelli, G., Serra, C., Neri, S., Pignataro, P., Rizzetto, M., Debernardi, V. W., Svegliati, B. G., Bergamaschi, G., Masotti, M., Costanzo, F., Antonio, F., Angelico, F., Del Ben, M., Polimeni, L., Proietti, M., Cangemi, R., Romiti, G. F., Toriello, F., Sperduti, N., Santangelo, G., Visioli, G., Todisco, T., Vestri Anna, R., Farcomeni, A., Corrao, S., Gobbi, P., Corradini, E., Costantino, G., Tripepi, G., Angelico, M., D'Amico, G., De Franchis, R., Gatta, A., Tassone, E. J., Anzaldi, M., Barone, M., Bazzini, C., Bianchi, P. I., Boari, B., Bracco, C., Buonauro, A., Butta, C., Buzzetti, E., Calabria, S., Caradio, F., Carleo, P., Carrabba Maria, D., Castorani, L., Cicco, S., Cimini, C., Colombo, B. M., De Vuono, S., Denegri, A., Del Corso, L., Di Giosia, P., Donnarumma, E., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Miceli, G., Montebianco, A. L., Murgia, G., Naccarato, P., Padula, D., Pattoneri, P., Perego, F., Pesce, P., Petramala, L., Piano, S., Pinto, D., Pinna, M., Pignataro, F. S., Pretti, V., Pucci, G., Salinaro, F., Salzano, A., Santarossa, C., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Torres, D., Traversa, M., Vazzana, N., Vecchio Claudia, R., Vettore, E., and Vitale, F.

Subjects
Liver Cirrhosis, Male, Settore MED/09 - Medicina Interna, 030204 cardiovascular system & hematology, Gastroenterology, Severity of Illness Index, cjirrhosis, ACTIVATION, 0302 clinical medicine, Risk Factors, Medicine, Platelet, Prospective Studies, Prospective cohort study, RISK, Aged, 80 and over, medicine.diagnostic_test, PRO-LIVER, Platelet, cirrhosis, gastrointestinal bleeding, ASSOCIATION, Middle Aged, Prognosis, Italy, 030211 gastroenterology & hepatology, Female, Gastrointestinal Hemorrhage, Human, Adult, Platelets, medicine.medical_specialty, Prognosi, Liver Cirrhosi, MEDLINE, COAGULATION, gastrointestinal bleeding, Socio-culturale, Hemorrhage, Hepatology, Follow-Up Studie, 03 medical and health sciences, Text mining, Internal medicine, Severity of illness, ENDOTOXEMIA, Pro-Liver Study, Humans, HEMOSTASIS, International Normalized Ratio, Aged, Proportional Hazards Models, Prothrombin time, Cirrhosi, Platelet Count, Bleeding, Liver Cirrhosis, business.industry, Proportional hazards model, Platelet Count, Risk Factor, cirrhosis, bleeding, Thrombocytopenia, Prospective Studie, THROMBOSIS, Platelets, cjirrhosis, bleeding, PRO-LIVER, Proportional Hazards Model, Prothrombin Time, business, DECOMPENSATED CIRRHOSIS, Follow-Up Studies
Abstract

OBJECTIVES: Thrombocytopenia is a hallmark for patients with cirrhosis and it is perceived as a risk factor for bleeding events. However, the relationship between platelet count and bleeding is still unclear. METHODS: We investigated the relationship between platelet count and major or clinical relevant nonmajor bleedings during a follow-up of ∼4 years. RESULTS: A total of 280 cirrhotic patients with different degrees of liver disease (67% males; age 64±37 years; 47% Child–Pugh B and C) were followed up for a median of 1,129 (interquartile range: 800–1,498) days yielding 953.12 patient-year of observation. The annual rate of any significant bleeding was 5.45%/year (3.57%/year and 1.89%/year for major and minor bleeding, respectively). Fifty-two (18.6%) patients experienced a major (n=34) or minor (n=18) bleeding event, predominantly from gastrointestinal origin. Platelet counts progressively decreased with the worsening of liver disease and were similar in patients with or without major or minor bleeding: a platelet count ≤50×103/μl was detected in 3 (6%) patients with and in 20 (9%) patients without any bleeding event. Conversely, prothrombin time-international normalized ratio was slightly higher in patients with overall or major bleeding. On Cox proportional hazard analysis, only a previous gastrointestinal bleeding (hazard ratio (HR): 1.96; 95% confidence interval: 1.11–3.47; P=0.020) and encephalopathy (HR: 2.05; 95% confidence interval: 1.16–3.62; P=0.013) independently predicted overall bleeding events. CONCLUSIONS: Platelet count does not predict unprovoked major or minor bleeding in cirrhotic patients.

Published
2018

20. Alectinib rescue therapy in advanced ALK rearranged lung adenocarcinoma: a case report

Author

Cristiano Cesaro, Umberto Caterino, Fabio Perrotta, Umberto Masi, Alessandra Cotroneo, Roberta Cianci, Enzo Zamparelli, Flavio Cesaro, Dario Amore, Danilo Rocco, Cesaro, Cristiano, Caterino, Umberto, Perrotta, Fabio, Masi, Umberto, Cotroneo, Alessandra, Cianci, Roberta, Zamparelli, Enzo, Cesaro, Flavio, Amore, Dario, and Rocco, Danilo

Subjects
Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine
Abstract

Alectinib is a highly selective tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) that is approved as first-line treatment in adult patients with ALK-positive non-small cell lung cancer (NSCLC) and as second-line in patients previously treated with crizotinib, and has been shown in the literature to significantly prolong progression-free survival compared to chemotherapy in patients with advanced non-small cell lung cancer. The authors describe a clinical case of a 24-year-old woman with malignant massive pleural effusion caused by ALK rearranged pulmonary adenocarcinoma with pleural and pericardial metastasis, in which, despite a dramatic clinical debut, the correct and timely management of the diagnostic and therapeutic path allowed for extraordinary therapeutic success.

Published
2022

21. Arrhythmic triad in an implantable cardioverter-defibrillator recipient with severe hypokalemia

Author

Giovanni Domenico Ciriello, Gabriella Gaudieri, Flavio Cesaro, Raffaele Merenda, Vincenzo Russo, Ciriello, Giovanni Domenico, Gaudieri, Gabriella, Cesaro, Flavio, Merenda, Raffaele, and Russo, Vincenzo

Subjects
malignant ventricular arrhythmia, ineffective shock, hypokalemia, Cardiology and Cardiovascular Medicine, ventricular defibrillation threshold
Published
2022

22. Emergency department care of ABSSSI with dalbavancin infusion, direct discharge, and outpatient telemedicine follow up: a study protocol

Author

Emanuele Durante-Mangoni, Alessandro Riccardi, Mario Guarino, Flavio Cesaro, Marina Lugarà, Silvia Mascolo, Lucia Morelli, Vincenzo Natale, Massimo Andreoni, Durante-Mangoni, Emanuele, Riccardi, Alessandro, Guarino, Mario, Cesaro, Flavio, Lugarà, Marina, Mascolo, Silvia, Morelli, Lucia, Natale, Vincenzo, and Andreoni, Massimo

Subjects
Pharmacology, Infectious Diseases, Oncology, emergency department, Dalbavancin, skin and soft tissue infection, Pharmacology (medical), gram-positive, telehealth follow-up
Abstract

Novel therapeutic strategies such as the long-acting lipoglycopeptide antibiotics allow for the treatment and discharge of selected emergency department (ED) patients with Acute Bacterial Skin and Skin Structure Infections (ABSSSI), who require intravenous antibiotics and would otherwise be hospitalized. The COVID-19 pandemic highlighted the need to develop strategies that may reduce hospitalization. The telehealth approach has shown success in remote management of cellulitis patients and could aid in the remote follow up of overall ABSSSI patients. This article describes a study protocol for the telemedicine follow up of patients diagnosed with ABSSSI in the ED, requiring intravenous treatment, receiving a single dalbavancin dose, and directly discharged. A telehealth system for remote follow up is evaluated as well as the possible inclusion of point-of-care ultrasound for the appropriate diagnosis of ABSSSI. The study will be conducted in compliance with regulatory requirements; and all collected data will be kept strictly confidential and in accordance with all relevant legislation on the control and protection of personal information. Dissemination of the study protocol may help increasing knowledge and awareness on this topic, with the aim of optimizing patient management, reducing hospitalization and lower the impact on healthcare associated costs.

Published
2022

23. Incidence and Recurrence of Portal Vein Thrombosis in Cirrhotic Patients

Author

Violi, F., Corazza, G. R., Caldwell, S. H., Talerico, G., Romiti, G. F., Napoleone, L., Perticone, F., Bolondi, L., Pietrangelo, A., Vestri, A. R., Raparelli, V., Basili, S., Elena, A. M., Paola, A., Angelo, A., Bottino, Francesco, Mario, A., Antonio, F., Massimiliano, A., Umberto, A., Maurizio, A., Milena, B., Cristina, B., Gaetano, B., Michele, B., Battista, B. G., Ilaria, B. P., Benedetta, B., Giancarlo, B., Christian, B., Silvia, B., Agostino, B., Carmelo, B., Buzzetti, E., Irene, C., Stefano, C., Roberto, C., William, C., Santagati, Federica, Isabella, C., Pietro, C., Benedetto, C., Domenica, C. M., Luigi, C., Maurizio, C., Lara, C., Flavio, C., Sebastiano, C., Claudia, C., Maria, C. B., Elena, C., Amato, Salvatore, Giorgio, C., Filippo, C., Giuseppe, C., Chiara, C., Valentina, C., Felicia, D., Gennaro, D., Roberto, D. F., Alfredo, D. G., Stefano, D. V., Wilma, D. V., Maria, D. B., Lisette, D. C., Giuseppe, D., Andrea, D., Valentina, D. C., Paolo, D. G., Dario, D. M., Giovanni, D. M., Emilia, D., Davide, D., Emanuele, D. -M., Falsetti, L., Alessio, F., Vincenza, F., Silvano, F., Giovanni, F., Tiziana, F., Alessandra, F., Pierluigi, F., Giovanni, G., Vigneri, Paolo, Matteo, G., Ruggiero, G., Antonio, G., Angelo, G., Antonina, G., Gianluigi, G., Alessandro, G., Davide, G., Daniel, H., Angelo, I., Luigi, I., Pietro, I., Antonio, I., Giacomo, L., Anna, L., Livia, L. M., Giusi, L., Sergio, M., Roberto, M., Matteo, M., Alessandra, M., Sara, M., Maria, M. A., Pio, M. G., Maristella, M., Michela, M., Antonio, M., Giuseppe, M., Ludovico, M. A., Ignazio, M., Olivia, M., Paola, N., Sergio, N., Grazia, N., Lorenzo, N., Donatella, P., Giuseppe, P., Ostilio, P. V., Daniele, P., Francesca, P., Maria, P., Paola, P., Luigi, P., Irene, P., Salvatore, P., Antonio, P., Serena, P. F., Pietro, P., Pasquale, P., Miriam, P., Daniela, P., Licia, P., Vincenzo, P., Graziella, P., Giacomo, P., Francesco, P., Enrico, R., Giovanni, R., Tea, R., Laura, R., Mario, R., Isabel, R. -C. K., Giulio, R. R., Eleonora, R., David, S., Francesco, S., Aldo, S., Andrea, S., Giuseppe, S., Claudia, S., Francesca, S., Daniela, S., Cosima, S., Roberto, S., Marco, S., Carla, S., Gaetano, S., Domenico, S., Maurizio, S., Nicolo, S., Silvia, S., Orietta, S., Stasi, C., Patrizia, S., Gianluca, S. B., Michela, T., Claudio, T., Joseph, T. E., Tommaso, T., Filippo, T., Daniele, T., Matteo, T., Giovanni, T., Antonella, T., Antonino, T., Doriana, V., Natale, V., Rita, V. C., Gianluigi, V., Paolo, V., Umberto, V. -G., Elia, V., Gianpaolo, V., Villani, R., Ronca, V., Giacomo, V., Francesco, V., Assunta, Z. M., Paolo, P., Marco, P., and Francesco Violi, Gino Roberto Corazza, Stephen H. Caldwell, Giovanni Talerico, Giulio Francesco Romiti, Laura Napoleone, Francesco Perticone, Luigi Bolondi, Antonello Pietrangelo, Anna Rita Vestri, Valeria Raparelli, Stefania Basili, Ainora Maria Elena, Andreozzi Paola, AndriulliAngelo,Angelico Francesco, Angelico Mario, Figliomeni Antonio, Anzaldi Massimiliano, Arena Umberto, Averna Maurizio, Barone Milena, Bazzini Cristina, Bergamaschi Gaetano, Bertoni Michele, Bianchi, Giovanni Battista, Bianchi Paola Ilaria, Boari Benedetta, Bombonato Giancarlo, Bracco Christian, Brocco Silvia, Buonauro, Agostino, Buttà Carmelo, Buzzetti Elena, Cacciola Irene, Calabria Stefano, Cangemi Roberto, Capeci William, Caradio, Federica, Carderi Isabella, Carleo Pietro, Caroleo Benedetto, Carrabba Maria Domenica, Castorani Luigi, Cavallo Maurizio, Cecchetto Lara, Cesaro Flavio, Cicco Sebastiano, Cimini Claudia, Colombo Barbara Maria, Corradini Elena, Corrao Salvatore, Costantino Giorgio, Costanzo Filippo, Croce Giuseppe, Cuoghi Chiara, Curigliano Valentina, D’Alitto Felicia, D’Amico Gennaro, De Franchis Roberto, De Giorgi Alfredo, De Vuono Stefano, Debernardi Venon Wilma, Del Ben Maria, Del Corso Lisette, Delitala Giuseppe, Denegri Andrea, Di Cesare Valentina, Di Giosia Paolo, Di Michele Dario, Di Minno Giovanni, Donnarumma Emilia, Drenaggi Davide, Durante-Mangoni Emanuele, Falsetti Lorenzo, FarcomeniAlessio, FarinaroVincenza, Fasolato Silvano, Ferrari Giovanni, Fierro Tiziana, Forgione Alessandra, Frugiuele Pierluigi, Galati Giovanni, Gallo Paolo, Garcovich Matteo, Gargano Ruggiero, Gasbarrini Antonio, Gatta Angelo, Giammanco Antonina, Giannelli Gianluigi, Giorgini Paolo, Gobbi Paolo, Granito Alessandro, GrassiDavide, Greco Antonio, Grembiale Alessandro, Gresele Paolo, Hijazi Daniel, Iacobellis, Angelo, Iamele Luigi, Invernizzi Pietro, Ippolito Antonio, Laffi, Giacomo, Licata Anna, Liguori Maria Livia, Lorusso Giusi, Maimone Sergio, Manfredini Roberto, Marcacci Matteo, Marchese Alessandra, Marinelli Sara, Marra Alberto Maria, Martino Giuseppe Pio, Masala Maristella, Masotti Michela, Merla Antonio, Miceli Giuseppe, Montebianco Abenavoli Ludovico, Morana Ignazio, Morelli Olivia, Murgia Giuseppe, Naccarato Paola, Neri Sergio, Niro Grazia, Nobili Lorenzo, Padula Donatella, PalascianoGiuseppe, PalmieriVincenzoOstilio, PastoriDaniele, Pattoneri Paolo, Perego Francesca, Perticone Maria, Pesce Paola, Petramala Luigi, Pettinari Irene, Piano Salvatore, Picardi Antonio, Pignataro Francesca Serena, Pignataro Pietro, Pignatelli Pasquale, PinnaMiriam, Pinto Antonio, Pinto Daniela, Polimeni Licia, Pretti Vincenzo, Privitera Graziella, Proietti Marco, Pucci Giacomo, Purrello Francesco, Ragone Enrico, Raimondo Giovanni, Restuccia Tea, Riccardi Laura, RizzettoMario, Rodríguez- Castro Kryssia Isabel, Romanelli Roberto Giulio, Ruscio Eleonora, Sacerdoti David, Salinaro Francesco, Salvi Aldo, Salzano Andrea, SantangeloGiuseppe, Santarossa Claudia, Santilli Francesca, Santovito Daniela, Scarpini Francesca, Schiavone Cosima, Scicali Roberto, SenzoloMarco, Serra Carla, Serviddio Gaetano, Sirico Domenico, Soresi Maurizio, Sperduti Nicolò, Staffolani Silvia, Staltari Orietta, Stasi Cristina, Suppressa Patrizia, Svegliati Baroni Gianluca, Talia Michela, Tana Claudio, Tassone Eliezer Joseph, Todisco Tommaso, Toriello Filippo, Torres Daniele, Traversa Matteo, Tripepi Giovanni, Tufano Antonella, Tuttolomondo Antonino, Varvara Doriana, Vazzana Natale, Vecchio Claudia Rita, Vendemiale Gianluigi, Ventura Paolo, Vespasiani-Gentilucci Umberto, Vettore Elia, Vidili Gianpaolo, Villani Rosanna, Vincenzo Ronca, Visioli Giacomo, Vitale Francesco, Zocco Maria Assunta.

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Letter to the editor, Time Factors, MEDLINE, Portal Vein Thrombosis Cirrhotic Patients, outcomes, NO, coagulopathy, Recurrence, Risk Factors, Medicine, Humans, Aged, Female, Incidence, Italy, Middle Aged, Prospective Studies, Registries, Ultrasonography, Doppler, Venous Thrombosis, Portal Vein, portal vein thrombosis, Prospective cohort study, risk-factors, liver-transplantation, mortality, Ultrasonography, business.industry, Incidence (epidemiology), portal vein thrombosis, liver-transplantation, risk-factors, coagulopathy, mortality, outcomes, Doppler, Hematology, medicine.disease, Portal vein thrombosis, Radiology, business
Abstract

Cirrhosis has been long considered a risk factor for bleeding due to the co-existence of the so-called ‘coagulopathy’. More recently, however, compelling evidences have been provided on the occurrence of thrombotic events in the portal and systemic circulation.3–5 Portal vein thrombosis (PVT) is predominantly observed in patients with moderate to severe liver failure with a variable prevalence ranging from 0.6 to 25%. Only fewstudies have provided a longitudinal assessment of the PVT incidence and its sequelae, including recurrence and survival.9–14 Due to the variability of PVT incidence and the paucity of data regarding recurrence and survival,15–20 we prospectively analysed the incidence and the recurrence of PVT in the population of Portal vein thrombosis Relevance On Liver cirrhosis: ItalianVenous thromboticEventsRegistry (PROLIVER), a multi-centre study,8 which involved 43 enrolling centres in Italy (ClinicalTrials.gov Identifier: NCT01470547).

Published
2019

24. Emergency department care of ABSSSI with dalbavancin infusion, direct discharge, and outpatient telemedicine follow up: a study protocol.

Author

Durante-Mangoni E, Riccardi A, Guarino M, Cesaro F, Lugarà M, Mascolo S, Morelli L, Natale V, and Andreoni M

Subjects
Humans, Patient Discharge, Outpatients, Pandemics, Anti-Bacterial Agents, Emergency Service, Hospital, Skin Diseases, Bacterial drug therapy, COVID-19, Telemedicine
Abstract

Novel therapeutic strategies such as the long-acting lipoglycopeptide antibiotics allow for the treatment and discharge of selected emergency department (ED) patients with Acute Bacterial Skin and Skin Structure Infections (ABSSSI), who require intravenous antibiotics and would otherwise be hospitalized. The COVID-19 pandemic highlighted the need to develop strategies that may reduce hospitalization. The telehealth approach has shown success in remote management of cellulitis patients and could aid in the remote follow up of overall ABSSSI patients. This article describes a study protocol for the telemedicine follow up of patients diagnosed with ABSSSI in the ED, requiring intravenous treatment, receiving a single dalbavancin dose, and directly discharged. A telehealth system for remote follow up is evaluated as well as the possible inclusion of point-of-care ultrasound for the appropriate diagnosis of ABSSSI. The study will be conducted in compliance with regulatory requirements; and all collected data will be kept strictly confidential and in accordance with all relevant legislation on the control and protection of personal information. Dissemination of the study protocol may help increasing knowledge and awareness on this topic, with the aim of optimizing patient management, reducing hospitalization and lower the impact on healthcare associated costs.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results