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223 results on '"Cesareo, Massimo"'

4. Longitudinal Structural and Functional Evaluation of Dark-without-Pressure Fundus Lesions in Patients with Autoimmune Diseases.

Author

Lombardo, Marco, Ricci, Federico, Cusumano, Andrea, Falsini, Benedetto, Nucci, Carlo, and Cesareo, Massimo

Subjects
FLUORESCENCE angiography, OPTICAL coherence tomography, INDOCYANINE green, COLOR photography, AUTOIMMUNE diseases
Abstract

Objectives: The main objective of this study was to report and investigate the characteristics and longitudinal changes in dark-without-pressure (DWP) fundus lesions in patients with autoimmune diseases using multimodal imaging techniques. Methods: In this retrospective observational case series, five patients affected by ocular and systemic autoimmune disorders and DWP were examined. DWP was assessed by multimodal imaging, including color fundus photography (CFP), near-infrared reflectance (NIR), blue reflectance (BR), blue autofluorescence (BAF), optical coherence tomography (OCT), OCT-angiography (OCT-A), fluorescein angiography (FA) and indocyanine green angiography (ICGA), and functional testing, including standard automated perimetry (SAP) and electroretinography (ERG). Follow-up examinations were performed for four out of five patients (range: 6 months–7 years). Results: DWP fundus lesions were found in the retinal mid-periphery and were characterized by the hypo-reflectivity of the ellipsoid zone on OCT. DWP appeared hypo-reflective in NIR, BR and BAF, and exhibited hypo-fluorescence in FA in two patients while showing no signs in one patient. ICGA showed hypo-fluorescent margins in one patient. SAP and ERG testing did not show alterations attributable to the DWP lesion. Follow-up examinations documented rapid dimensional changes in DWP even in the short term (1 month). Conclusions: This study suggests a possible association between autoimmune diseases and DWP. New FA and ICGA features were described. The proposed pathogenesis hypotheses may operate as a basis for further investigation of a lesion that is still largely unknown. Large population studies would be necessary to confirm whether there is a higher incidence of DWP in this patient category. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Relationship between retinal microvascular impairment and subclinical atherosclerosis in SLE

Author

Ferrigno, Sara, primary, Conigliaro, Paola, additional, Rizza, Stefano, additional, Longo, Susanna, additional, Nesi, Carolina, additional, Carlucci, Federico, additional, Bergamini, Alberto, additional, Mancino, Raffaele, additional, Nucci, Carlo, additional, Federici, Massimo, additional, Chimenti, Maria Sole, additional, and Cesareo, Massimo, additional

Published
2023
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18. Subclinical microvascular changes in ANCA-vasculitides: the role of optical coherence tomography angiography and nailfold capillaroscopy in the detection of disease-related damage.

Author

Triggianese, Paola, primary, D'Antonio, Arianna, additional, Nesi, Carolina, additional, Kroegler, Barbara, additional, Marino, Matteo Di, additional, Conigliaro, Paola, additional, Modica, Stella, additional, Greco, Elisabetta, additional, Nucci, Carlo, additional, Bergamini, Alberto, additional, Chimenti, Maria Sole, additional, and Cesareo, Massimo, additional

Published
2023
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32. Subclinical Signs of Retinal Involvement in Hereditary Angioedema

Author

Triggianese, Paola, primary, Di Marino, Matteo, additional, Nesi, Carolina, additional, Greco, Elisabetta, additional, Modica, Stella, additional, Chimenti, Maria, additional, Conigliaro, Paola, additional, Mancino, Raffaele, additional, Nucci, Carlo, additional, and Cesareo, Massimo, additional

Published
2021
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33. Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis

Author

Martucci, Alessio, primary, Landi, Doriana, additional, Cesareo, Massimo, additional, Di Carlo, Emiliano, additional, Di Mauro, Giovanni, additional, Sorge, Roberto Pietro, additional, Albanese, Maria, additional, Gabri Nicoletti, Carolina, additional, Mataluni, Giorgia, additional, Mercuri, Nicola Biagio, additional, Di Marino, Matteo, additional, Aiello, Francesco, additional, Centonze, Diego, additional, Nucci, Carlo, additional, Marfia, Girolama Alessandra, additional, and Mancino, Raffaele, additional

Published
2021
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35. Assessment of microvascular involvement in lupus nephritis patients by retinal OCT-angiography and kidney biopsies

Author

Conigliaro, Paola, primary, Giannini, Clarissa, additional, Ferrigno, Sara, additional, Nesi, Carolina, additional, Fonti, Giulia Lavinia, additional, Chimenti, Maria Sole, additional, Triggianese, Paola, additional, Aiello, Francesco, additional, Nucci, Carlo, additional, Bergamini, Alberto, additional, and Cesareo, Massimo, additional

Published
2021
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36. Optical coherence tomography angiography in the multimodal assessment of the retinal posterior pole in autosomal dominant optic atrophy

Author

Cesareo, Massimo, primary, Giannini, Clarissa, additional, Di Marino, Matteo, additional, Aloe, Gianluca, additional, Martucci, Alessio, additional, Aiello, Francesco, additional, Cusumano, Andrea, additional, Mancino, Raffaele, additional, Ricci, Federico, additional, Sorge, Roberto Pietro, additional, and Nucci, Carlo, additional

Published
2021
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38. The Retinal Posterior Pole in Early Parkinson’s Disease: A Fundus Perimetry and SD-OCT Study

Author

Cesareo,Massimo, Di Marco,Ernesto, Giannini,Clarissa, Di Marino,Matteo, Aiello,Francesco, Pisani,Antonio, Pierantozzi,Mariangela, Mercuri,Nicola Biagio, Nucci,Carlo, Mancino,Raffaele, Cesareo,Massimo, Di Marco,Ernesto, Giannini,Clarissa, Di Marino,Matteo, Aiello,Francesco, Pisani,Antonio, Pierantozzi,Mariangela, Mercuri,Nicola Biagio, Nucci,Carlo, and Mancino,Raffaele

Abstract

Massimo Cesareo,1 Ernesto Di Marco,1 Clarissa Giannini,1 Matteo Di Marino,1 Francesco Aiello,1 Antonio Pisani,2 Mariangela Pierantozzi,3 Nicola Biagio Mercuri,4,5 Carlo Nucci,1 Raffaele Mancino1 1Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; 3Parkinson’s Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 4Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 5Fondazione Santa Lucia I.R.C.C.S, Rome, ItalyCorrespondence: Massimo Cesareo; Ernesto Di MarcoOphthalmology Unit, Department of Experimental Medicine University of Rome “Tor Vergata”, via Montpellier, Rome, 100133, ItalyTel/Fax +39 0620902973Email massimo.cesareo@uniroma2.it; Ernesto2601@hotmail.itPurpose: To assess the structure and function of the retinal posterior pole in patients with early Parkinson’s disease (PD) and to identify possible biomarkers correlated with clinical features.Patients and Methods: A cross-sectional case-control study of 21 patients with PD and 22 age-matched healthy controls (HC) was conducted. All subjects underwent full ophthalmological examinations, fundus perimetry (FP) and spectral domain-OCT (SD-OCT) of the entire retinal posterior pole and peripapillary retinal nerve fiber layer (pRNFL).Results: We analyzed 41 eyes from 21 patients (14 males and 7 females) with early PD (Hoehn and Yahr scale (H&Y) equal to or less than stage 2) and 41 eyes from 22 HC (12 males and 10 females). We found no significant difference in the pRNFL thickness between patients with PD and HC. The statistical analysis of the SD-OCT posterior pole area, consisting of 64 values for each retinal layer, revealed a decrease in the outer nuclear layer (ONL) thickness in patients with PD (p < 0.0001). On the contrary, a significant increase in the thickness of the outer plexiform layer (OPL) (p

Published
2021

41. MOESM1 of Evaluation of retinal microvascular perfusion in hereditary angioedema: a case-control study

Author

Triggianese, Paola, Cesareo, Massimo, Guarino, Maria, Conigliaro, Paola, Chimenti, Maria, Cedola, Francesca, Mazzeo, Caterina, Nucci, Carlo, and Perricone, Roberto

Subjects
genetic structures, eye diseases
Abstract

Additional file 1. Immunologic assessment. Table S1. Optical coherence tomography angiography findings from the study population. Figure S1. Representative 3 × 3-mm angiograms of retinal imaging on optical coherence tomography angiography.

Published
2020
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46. Optical coherence tomography angiography in the multimodal assessment of the retinal posterior pole in autosomal dominant optic atrophy.

Author

Cesareo, Massimo, Giannini, Clarissa, Di Marino, Matteo, Aloe, Gianluca, Martucci, Alessio, Aiello, Francesco, Cusumano, Andrea, Mancino, Raffaele, Ricci, Federico, Sorge, Roberto Pietro, and Nucci, Carlo

Subjects
*OPTICAL coherence tomography, *ANGIOGRAPHY, *ATROPHY, *RECEIVER operating characteristic curves, *VISUAL acuity, *EYE, *NERVE fibers
Abstract

Purpose: To assess retinal vascular involvement in patients with autosomal dominant optic atrophy (ADOA) genetically confirmed by the presence of the OPA1 (Optic Atrophy 1) gene mutation using a multimodal protocol of investigation of retinal posterior pole. Methods: In this cross‐sectional, case–control, observational study, both eyes of 13 patients with a genetic diagnosis of ADOA were compared with both eyes of 13 healthy controls (HCs). All subjects underwent full ophthalmological examination, spectral domain‐optical coherence tomography (SD‐OCT), fundus perimetry (FP) and OCT angiography (OCTA). Results: Vessel density (VD) of the superficial and deep macular vascular plexi and of the radial peripapillary capillary plexus were significantly decreased (p ≤ 0.001) in ADOA patients compared with HCs. The area under the receiver operating characteristics analysis also revealed high values of sensitivity and specificity of OCTA parameters in distinguish between patients and HCs. A strong correlation (Pearson Coefficient, r = 0.91) emerged between OCTA VD of the superficial retinal plexus and the average Ganglion Cell Layer (GCL) thickness as measured by SD‐OCT; a slightly lower correlation (Pearson Coefficient, r = 0.89) was also found between VD of the deep plexus and the average GCL thickness of the same eyes in patients with ADOA. The correlation among values of differential light sensitivity (DLS) measured by FP with VD and GCL thickness parameters was also investigated. The correlation analysis among DLS and the VD parameters showed from low‐to‐moderate correlation (ranging from r = 0.29 for the deep fovea VD to r = 0.59 for the deep whole image VD). The correlation coefficient between the mean DLS and the average thickness of GCL was more significant (Pearson Coefficient, r = 0.75). A significant correlation emerged also between the VD and the visual acuity, in terms of LogMAR BCVA (best‐corrected visual acuity), especially for the VD of the deep capillary plexus (Pearson Coefficient for the Deep whole Image VD and LogMAR BCVA r = −0.75; for the Deep parafovea VD and LogMAR BCVA r = −0.78). Conclusion: Retinal microvascular assessment by OCTA angiography can provide relevant clinical information on retinal involvement in ADOA patients. In patients with genetically confirmed OPA1‐related ADOA, there is a decrease in retinal vessel density associated with GCL thinning and DLS reduction. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Diffusional Kurtosis Imaging of White Matter Degeneration in Glaucoma

Author

Nucci, Carlo, primary, Garaci, Francesco, additional, Altobelli, Simone, additional, Di Ciò, Francesco, additional, Martucci, Alessio, additional, Aiello, Francesco, additional, Lanzafame, Simona, additional, Di Giuliano, Francesca, additional, Picchi, Eliseo, additional, Minosse, Silvia, additional, Cesareo, Massimo, additional, Guerrisi, Maria Giovanna, additional, Floris, Roberto, additional, Passamonti, Luca, additional, and Toschi, Nicola, additional

Published
2020
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49. Retinal and Choroidal Vasculature in Patients with Marfan Syndrome

Author

Di Marino, Matteo, primary, Cesareo, Massimo, additional, Aloe, Gianluca, additional, Nucci, Carlo, additional, Giannini, Clarissa, additional, Martucci, Alessio, additional, Aiello, Francesco, additional, Pisano, Calogera, additional, Ruvolo, Giovanni, additional, and Mancino, Raffaele, additional

Published
2020
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50. A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

Author

Chimenti, Maria Sole, primary, Triggianese, Paola, additional, Salandri, Giorgia, additional, Conigliaro, Paola, additional, Canofari, Claudia, additional, Caso, Francesco, additional, Costa, Luisa, additional, Nucci, Carlo, additional, Aiello, Francesco, additional, Cesareo, Massimo, additional, and Perricone, Roberto, additional

Published
2020
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