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3. Higher testosterone is associated with increased inflammatory markers in women with SARS-CoV-2 pneumonia: preliminary results from an observational study

Author

Di Stasi, V., primary, Rastrelli, G., additional, Inglese, F., additional, Beccaria, M., additional, Garuti, M., additional, Di Costanzo, D., additional, Spreafico, F., additional, Cervi, G., additional, Greco, G. F., additional, Pecoriello, A., additional, Todisco, T., additional, Cipriani, S., additional, Maseroli, E., additional, Scavello, I., additional, Glingani, C., additional, Franchini, M., additional, Maggi, M., additional, De Donno, G., additional, and Vignozzi, L., additional

Published
2021
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4. Self-efficacy in breastfeeding support: A research on italian midwifery students

Author

Prepelita, T, Ricchi, A, Messina, P, Molinazzi, M, Cappadona, R, Fieschi, L, Nespoli, A, Guana, M, Cervi, G, Parma, D, Mauri, P, Artioli, G, Banchelli, F, Foa, C, Neri, I, Molinazzi, MT, Mauri, PA, Prepelita, T, Ricchi, A, Messina, P, Molinazzi, M, Cappadona, R, Fieschi, L, Nespoli, A, Guana, M, Cervi, G, Parma, D, Mauri, P, Artioli, G, Banchelli, F, Foa, C, Neri, I, Molinazzi, MT, and Mauri, PA

Abstract

Background and aim of the study: Maternal breastmilk represents the best nourishment for the newborn baby during its first six months, as it offers several benefits for the health and well-being of babies and mothers. In order to promote, protect and support effectively mother and child during breastfeeding, it is essential for midwives to be properly educated and to acquire highly professionalizing skills. This study aimed to evaluate the level of self-efficacy of the students attending the Degree Course of Midwifery, regarding the support of mother and child in breastfeeding. Method: A questionnaire of 37 items (Blackmanet al, 2015) validated in Italian by Mazzeo Melchionda (2019), was sent on-line to students of ten different Midwifery Degree Courses to assess their level of self-efficacy regarding the management of breastfeeding. Statistical analysis was carried out using statistic software R3.4.3 (The Foundation for Statistical Computing). Results: 158 questionnaires were collected from ten Italian Midwifery Degree Courses. The areas in which students showed a high level of self-efficacy in managing breastfeeding include: the benefits of breastfeeding; the child’s tendency to take the breast within an hour from childbirth and the relevance of skin to skin contact and rooming-in. Low levels of self-efficacy concerned the comfortably breastfeeding in public places and avoiding giving formula to the baby in its first six weeks of life. Conclusions: Generally the students attending Midwifery Degree Courses show a high level of self-efficacy in assisting mothers during breastfeeding and they prove to have a good knowledge of the benefits of breastfeeding to improve the health of mothers and their children. (www.actabiomedica.it).

Published
2020

6. Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Author

Arnold, FW, Lopardo, G, Wiemken, TL, Kelley, R, Peyrani, P, Mattingly, WA, Feldman, C, Gnoni, M, Maurici, R, Ramirez, JA, Arnold, F, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Vialea, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, DP, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, AD, Riquelme, R, Barros, M, Luna, JM, Toala, I, de Morvil, GAO, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, MP, Mateo, M, Mendoza, M, and CAPO

Subjects
Community-acquired pneumonia, Antimicrobial treatment, Bacteremia, Mortality
Abstract

Background: Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide. Materials and methods: Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a positive blood culture were categorized based on the presence or absence of a macrolide in their initial antimicrobial regimen, and severity of their CAP. Outcomes included inhospital all-cause mortality, 30-day mortality, length of stay, and time to clinical stability. Results: Among 549 patients with CAP and bacteremia, 247 (45%) were treated with a macrolide and 302 (55%) were not. The primary pathogen was Streptococcus pneumoniae (74%). Poisson regression with robust error variance models were used to compare the adjusted effects of each study group on the outcomes. The unadjusted 30-day mortality was 18.4% in the macrolide group, and 29.6% in the non-macrolide group (adjusted relative risk (aRR)0.81; 95% confidence interval (CI)0.50-1.33; P = 0.41). Unadjusted in-hospital all-cause mortality was 7.3% in the macrolide group, and 18.9% in the non-macrolide group (aRR 0.54, 95% CI 0.30-0.98; P = 0.043). Length of stay and time to clinical stability were not significantly different. Conclusions: In-hospital mortality, but not 30-day mortality, was significantly better in the macrolide group. Our data support the use of a macrolide in hospitalized patients with CAP and bacteraemia.

Published
2018

7. Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Author

Arnold, F, Lopardo, G, Wiemken, T, Kelley, R, Peyrani, P, Mattingly, W, Feldman, C, Gnoni, M, Maurici, R, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Viale, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, D, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, A, Riquelme, R, Barros, M, Luna, J, Toala, I, Oze de Morvil, G, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, M, Mateo, M, Mendoza, M, Arnold, Forest W., Lopardo, Gustavo, Wiemken, Timothy L., Kelley, Robert, Peyrani, Paula, Mattingly, William A., Feldman, Charles, Gnoni, Martin, Maurici, Rosemeri, Ramirez, Julio A., Arnold, Forest, Ramirez, Julio, Ayesu, Kwabena, File, Thomas, Burdette, Steven, Blatt, Stephen, Restrepo, Marcos, Bordon, Jose, Gross, Peter, Musher, Daniel, Marrie, Thomas, Weiss, Karl, Roig, Jorge, Lode, Harmut, Welte, Tobias, Aliberti, Stephano, Blasi, Francesco, Cosentini, Roberto, Legnani, Delfino, Franzetti, Fabio, Montano, Nicola, Cervi, Giulia, Rossi, Paolo, Voza, Antonio, Ostrowsky, Belinda, Pesci, Alberto, Nava, Stefano, Viale, Pierluigi, Galavatti, Vanni, Patricia, Aruj, Dimas, Carlos, Piro, Roberto, Viscoli, Claudio, Torres, Antoni, Valenti, Vincenzo, Ojales, Daniel Portela, Bodi, Maria, Porras, Jose, Rello, Jordi, Menendez, Rosario, Stolz, Daiana, Schuetz, Philipp, Haubitz, Sebastian, Chalmers, James, Fardon, Tom, Benchetrit, Guillermo, Rodriguez, Eduardo, Corral, Jorge, Gonzalez, Jose, de Vedia, Lautaro, Luna, Carlos, Martinez, Jorge, Marzoratti, Lucia, Rodriguez, Maria, Videla, Alejandro, Saavedra, Federico, Lopez, Horacio, Victorio, Carlos, Riera, Fernando, Jimenez, Patricio, Fernandez, Patricia, Parada, Maria, Fuenzalida, Alejandro Díaz, Riquelme, Raul, Barros, Manuel, Luna, Juan Manuel, Toala, Ivan, Oze de Morvil, Guillermo Arbo, Fernandez, Ricardo, Aiello, Gonzalo, Alvarez, Pablo, Soca, Ana, Arteta, Federico, Delgado, Jose, Levy, Gur, Rivero, Ludwig, Rodriguez, Benito, Mirabal, Mario Perez, Mateo, Marilyn, Mendoza, Myrna, Arnold, F, Lopardo, G, Wiemken, T, Kelley, R, Peyrani, P, Mattingly, W, Feldman, C, Gnoni, M, Maurici, R, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Viale, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, D, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, A, Riquelme, R, Barros, M, Luna, J, Toala, I, Oze de Morvil, G, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, M, Mateo, M, Mendoza, M, Arnold, Forest W., Lopardo, Gustavo, Wiemken, Timothy L., Kelley, Robert, Peyrani, Paula, Mattingly, William A., Feldman, Charles, Gnoni, Martin, Maurici, Rosemeri, Ramirez, Julio A., Arnold, Forest, Ramirez, Julio, Ayesu, Kwabena, File, Thomas, Burdette, Steven, Blatt, Stephen, Restrepo, Marcos, Bordon, Jose, Gross, Peter, Musher, Daniel, Marrie, Thomas, Weiss, Karl, Roig, Jorge, Lode, Harmut, Welte, Tobias, Aliberti, Stephano, Blasi, Francesco, Cosentini, Roberto, Legnani, Delfino, Franzetti, Fabio, Montano, Nicola, Cervi, Giulia, Rossi, Paolo, Voza, Antonio, Ostrowsky, Belinda, Pesci, Alberto, Nava, Stefano, Viale, Pierluigi, Galavatti, Vanni, Patricia, Aruj, Dimas, Carlos, Piro, Roberto, Viscoli, Claudio, Torres, Antoni, Valenti, Vincenzo, Ojales, Daniel Portela, Bodi, Maria, Porras, Jose, Rello, Jordi, Menendez, Rosario, Stolz, Daiana, Schuetz, Philipp, Haubitz, Sebastian, Chalmers, James, Fardon, Tom, Benchetrit, Guillermo, Rodriguez, Eduardo, Corral, Jorge, Gonzalez, Jose, de Vedia, Lautaro, Luna, Carlos, Martinez, Jorge, Marzoratti, Lucia, Rodriguez, Maria, Videla, Alejandro, Saavedra, Federico, Lopez, Horacio, Victorio, Carlos, Riera, Fernando, Jimenez, Patricio, Fernandez, Patricia, Parada, Maria, Fuenzalida, Alejandro Díaz, Riquelme, Raul, Barros, Manuel, Luna, Juan Manuel, Toala, Ivan, Oze de Morvil, Guillermo Arbo, Fernandez, Ricardo, Aiello, Gonzalo, Alvarez, Pablo, Soca, Ana, Arteta, Federico, Delgado, Jose, Levy, Gur, Rivero, Ludwig, Rodriguez, Benito, Mirabal, Mario Perez, Mateo, Marilyn, and Mendoza, Myrna

Abstract

Background: Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide. Materials and methods: Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a positive blood culture were categorized based on the presence or absence of a macrolide in their initial antimicrobial regimen, and severity of their CAP. Outcomes included in-hospital all-cause mortality, 30-day mortality, length of stay, and time to clinical stability. Results: Among 549 patients with CAP and bacteremia, 247 (45%) were treated with a macrolide and 302 (55%) were not. The primary pathogen was Streptococcus pneumoniae (74%). Poisson regression with robust error variance models were used to compare the adjusted effects of each study group on the outcomes. The unadjusted 30-day mortality was 18.4% in the macrolide group, and 29.6% in the non-macrolide group (adjusted relative risk (aRR)0.81; 95% confidence interval (CI)0.50–1.33; P = 0.41). Unadjusted in-hospital all-cause mortality was 7.3% in the macrolide group, and 18.9% in the non-macrolide group (aRR 0.54, 95% CI 0.30–0.98; P = 0.043). Length of stay and time to clinical stability were not significantly different. Conclusions: In-hospital mortality, but not 30-day mortality, was significantly better in the macrolide group. Our data support the use of a macrolide in hospitalized patients with CAP and bacteraemia

Published
2018

9. Clinical failure in hospitalized patients with community acquired pneumonia (CAP): Preliminary results from the FAILCAP study

Author

ALIBERTI, STEFANO, PESCI, ALBERTO, Morlacchi, L, Gramegna, A, Parazzini, E, Stolz, D, Ruvolo, L, Karrer, F, Cervi, G, Cosentini, R, Zanaboni, A, Marruchella, A, Magni, E, Peyrani, P, Ramirez, J, Blasi, F., Aliberti, S, Morlacchi, L, Gramegna, A, Parazzini, E, Stolz, D, Ruvolo, L, Karrer, F, Cervi, G, Cosentini, R, Zanaboni, A, Marruchella, A, Magni, E, Peyrani, P, Pesci, A, Ramirez, J, and Blasi, F

Subjects
MED/17 - MALATTIE INFETTIVE, MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, pneumonia, failure
Published
2011

10. Documento di indirizzo sulla valutazione dell’apprendimento delle competenze professionali acquisite in tirocinio dagli Studenti dei Corsi di Laurea delle Professioni Sanitarie

Author

Saiani L, Bielli S, Brugnolli A, Bettarelli G, Mazzoni G, Gugnali A, ma strillo A, Cantucci G, Tani C, Trenti R, Apollonio B, Bonera G, Castelvedere F, Ghitti G, Migliorati P, Motta PC, Rossini S, Scumà C, Bozzolan M, Canella C, Francioni S, Galantini P, Innocenti C, Vacchina I, Canepa M, Napoletano G, Lancia L, Petrucci C, Sicilia A, Bezze A, brogli F, Panzeri MC, Valle G, Dalponte A, Moranda D, Budriesi C, Canalini A, Canovi L, Contesini M, Fantuzzi AL, Ferri P, Frigieri F, Losi E, Saladini G, Bragagnolo B, Busa E, Ciulo R, Dorigo M, Fanton E, Zanotti R, Ascolese F, Vicario M, Mazzocchi B, agnolotti M, Del Bo E, Dal Molin A, Chilin G, Biancheri A, Pancrazi S, Sinibaldi S, Burlon B, Lombardi R, Altini P, Derossi A, Dimonte V, Persico A, Sampietro P, Tortola C, Marmo G, Achil I, Bulfone G, Bulfone T, Del Frari M, Fabris S, Papero M, Palese A, Rendoni R, Zanini A, Zavarise D, Zuliani S, Ambrosi E, Casna C, Chiesa S, Curzel M, Dalla Pozza M, Ferrari MG, Foroni M, Mantovan F, Marognolli O, Mazzurana M, Rigo F, Cervi G., MANARA , DUILIO FIORENZO, Saiani, L, Bielli, S, Brugnolli, A, Bettarelli, G, Mazzoni, G, Gugnali, A, ma strillo, A, Cantucci, G, Tani, C, Trenti, R, Apollonio, B, Bonera, G, Castelvedere, F, Ghitti, G, Migliorati, P, Motta, Pc, Rossini, S, Scumà, C, Bozzolan, M, Canella, C, Francioni, S, Galantini, P, Innocenti, C, Vacchina, I, Canepa, M, Napoletano, G, Lancia, L, Petrucci, C, Sicilia, A, Bezze, A, Brogli, F, Panzeri, Mc, Valle, G, Dalponte, A, Manara, DUILIO FIORENZO, Moranda, D, Budriesi, C, Canalini, A, Canovi, L, Contesini, M, Fantuzzi, Al, Ferri, P, Frigieri, F, Losi, E, Saladini, G, Bragagnolo, B, Busa, E, Ciulo, R, Dorigo, M, Fanton, E, Zanotti, R, Ascolese, F, Vicario, M, Mazzocchi, B, Agnolotti, M, Del Bo, E, Dal Molin, A, Chilin, G, Biancheri, A, Pancrazi, S, Sinibaldi, S, Burlon, B, Lombardi, R, Altini, P, Derossi, A, Dimonte, V, Persico, A, Sampietro, P, Tortola, C, Marmo, G, Achil, I, Bulfone, G, Bulfone, T, Del Frari, M, Fabris, S, Papero, M, Palese, A, Rendoni, R, Zanini, A, Zavarise, D, Zuliani, S, Ambrosi, E, Casna, C, Chiesa, S, Curzel, M, Dalla Pozza, M, Ferrari, Mg, Foroni, M, Mantovan, F, Marognolli, O, Mazzurana, M, Rigo, F, and Cervi, G.

Published
2011

12. Documento di indirizzo sulla valutazione dell'apprendimento delle competenze professionali acquisite in tirocinio dagli studenti dei Corsi di Laurea delle Professioni Sanitarie

Author

Saiani, L, Bielli, S, Brugnolli, A, e per il gruppo di lavoro: Lombardi R, Bozzolan, M, Canella, C, Galantini, P, Innocenti, C, Vacchina, F, Francioni, S, Broggi, F, Valle, G, Panzeri, Mc, Bezze, E, Dimonte, V, Altini, P, Persico, A, Sampietro, P, Tortola, C, Marmo, G, Derossi, Am, Dalponte, A, Manara, D, Moranda, D, Dorigo, M, Fanton, E, Bragagnolo, B, Ciulo, R, Busa, E, Zanotti, R, Vicario, M, Ascolese, F, Ambrosi, E, Marognolli, O, Casna, G, Foroni, M, Rigo, F, Curzel, M, Mazzurana, M, Ferrari, Mg, Chiesa, S, Mantovan, F, Dalla Pozza, A, Scumà, C, Motta, Pc, Migliorati, P, Ghitti, G, Castelvedere, F, Rossini, S, Apollonio, B, Bonera, G, Ferri, P, Losi, E, Budriesi, C, Fantuzzi, Al, Canalini, A, Frigieri, F, Saladini, G, Contesini, M, Canovi, L, Mazzocchi, B, Palese, A, Bulfone, G, Zanini, A, Fabris, S, Bulfone, T, Zuliani, S, Achil, I, Pajero, M, Zavarise, D, Del Frari, M, Rendoni, R, Sicilia, A, Gugnali, A, Tani, C, Santucci, G, Trenti, R, Mastrillo, A, Biancheri, A, Pancrazi, S, Burlon, B, Sinibaldi, E, Napoletano, G, Canepa, M, Cervi, G, Mazzoni, G, Bettarelli, G, Dal Molin, A, Chilin, G, Lancia, L, Petrucci, C, Del Bo, E, and Agnoletti, M.

Published
2011

13. [Surgical treatment of non-metastatic gastric GIST: two cases and review of the literature]

Author

Gheza, Federico, Pulcini, G., Cervi, Edoardo, Ferrari, A. B., Cesare, V. D., and Cervi, G. C.

Subjects
etiology/surgery, Anastomosis, Gastrointestinal Stromal Tumors, methods, Treatment Outcome, Gastrectomy, Stomach Neoplasms, Surgical, complications/pathology/surgery, 80 and over, Humans, Female, Aged, Aged, 80 and over, Anastomosis, Surgical, Female, Gastrectomy, methods, Gastrointestinal Hemorrhage, etiology/surgery, Gastrointestinal Stromal Tumors, complications/pathology/surgery, Humans, Stomach Neoplasms, complications/pathology/surgery, Treatment Outcome, Gastrointestinal Hemorrhage, Aged
Published
2010

14. MST e rischio riproduttivo

Author

Ricci, Giuseppe, Santis, M., Pagnini, G., Zito, Gabriella, Giolo, E., Cervi, G., Fisher Tamaro, L., Autori Vari, Ricci, Giuseppe, M., Santi, G., Pagnini, Zito, Gabriella, E., Giolo, G., Cervi, and L., Fisher Tamaro

Subjects
malattie sessualmente trasmissibili, Sterilità femminile
Abstract

Le MST provocano una compromissione della capacità riproduttiva, sia nella donna che nell'uomo, è di tipo prevalentemente immunitario, ne derivano importanti conseguenze. La terapia antibiotica risulterebbe del tutto inefficace. Risulta necessario sperimentare altre forme di terapia: antinfiammatori, immunosoppressori, anticitochine (ove disponibili).

Published
2007

15. [A case of amputation neuroma of the bile duct following video-laparoscopic cholecystectomy]

Author

Cimaschi, D., De Cesare, V., Pulcini, G., Cervi, Edoardo, Belloni, M., Liserre, B., and Cervi, G. C.

Subjects
Male, Anastomosis, Obstructive, Aged, Roux-en-Y, Cholecystectomy, Laparoscopic, Common Bile Duct Neoplasms, Humans, Jaundice, Neuroma, Treatment Outcome, Video-Assisted Surgery, Anastomosis, Roux-en-Y, Jaundice, Obstructive, Cholecystectomy, Laparoscopic
Abstract

We report a case of neuroma of the common hepatic duct arising five years after cholecystectomy (laparoscopic then converted in laparotomy). A 73-years-old patient was admitted for obstructive jaundice. Ultrasonography, TC and cholangiography showed a nodular lesion of the common hepatic of 1 cm in diameter, causing a regular and important stenosis of the main bile duct. Histologic examination demonstrated neuroma. By the analysis of this and 42 other previously published cases, the following features of bile duct neuroma were outlined: 1) variable interval between cholecystectomy and the onset of jaundice (2 months to 40 years); 2) the same incidence after laparoscopic or laparotomic cholecystectomy; 3) the generally complicated postoperative course after first surgical approach; 4) the various localizations on the biliary tree (cystic, main bile duct, intrahepatic ducts); 5) the circumstances of onset are almost the same (obstructive jaundice); 6) the histologic examination is mandatory for a correct diagnosis; and 7) the best treatment is resection of the bile duct tract involved in neuroma and reconstruction of biliary tree with hepaticojejunostomy.

Published
2006

16. Clinical failure in hospitalized patients with community acquired pneumonia (CAP): Preliminary results from the FAILCAP study

Author

Aliberti, S, Morlacchi, L, Gramegna, A, Parazzini, E, Stolz, D, Ruvolo, L, Karrer, F, Cervi, G, Cosentini, R, Zanaboni, A, Marruchella, A, Magni, E, Peyrani, P, Pesci, A, Ramirez, J, Blasi, F, ALIBERTI, STEFANO, PESCI, ALBERTO, Blasi, F., Aliberti, S, Morlacchi, L, Gramegna, A, Parazzini, E, Stolz, D, Ruvolo, L, Karrer, F, Cervi, G, Cosentini, R, Zanaboni, A, Marruchella, A, Magni, E, Peyrani, P, Pesci, A, Ramirez, J, Blasi, F, ALIBERTI, STEFANO, PESCI, ALBERTO, and Blasi, F.

Published
2011

17. Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor

Author

Casale, E., primary, Casuscelli, F., additional, Ardini, E., additional, Avanzi, N., additional, Cervi, G., additional, D'Anello, M., additional, Donati, D., additional, Faiardi, D., additional, Ferguson, R.D., additional, Fogliatto, G., additional, Galvani, A., additional, Marsiglio, A., additional, Mirizzi, D.G., additional, Montemartini, M., additional, Orrenius, C., additional, Papeo, G., additional, Piutti, C., additional, Salom, B., additional, and Felder, E.R., additional

Published
2013
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18. Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor

Author

Casale, E., primary, Casuscelli, F., additional, Ardini, E., additional, Avanzi, N., additional, Cervi, G., additional, D'Anello, M., additional, Donati, D., additional, Faiardi, D., additional, Ferguson, R.D., additional, Fogliatto, G., additional, Galvani, A., additional, Marsiglio, A., additional, Mirizzi, D.G., additional, Montemartini, M., additional, Orrenius, C., additional, Papeo, G., additional, Piutti, C., additional, Salom, B., additional, and Felder, E.R., additional

Published
2013
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19. Bicyclic carbohydrate-derived scaffolds for combinatorial libraries

Author

Cervi, G, Peri, F, Gennari, C, Battistini, C, Nicotra, F, PERI, FRANCESCO, NICOTRA, FRANCESCO, Cervi, G, Peri, F, Gennari, C, Battistini, C, Nicotra, F, PERI, FRANCESCO, and NICOTRA, FRANCESCO

Abstract

A bicyclic scaffold derived from the natural monosaccharide D-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-30 position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.

Published
2006

21. AURORA-A T288E COMPLEXED WITH PHA-828300

Author

Bindi, S., primary, Fancelli, D., additional, Alli, C., additional, Berta, D., additional, Bertrand, J.A., additional, Cameron, A.D., additional, Cappella, P., additional, Carpinelli, P., additional, Cervi, G., additional, Croci, W., additional, D'Anello, M., additional, Forte, B., additional, LauraGiorgini, M., additional, Marsiglio, A., additional, Moll, J., additional, Pesenti, E., additional, Pittala, V., additional, Pulici, M., additional, Riccardi-Sirtori, F., additional, Roletto, F., additional, Soncini, C., additional, Storici, P., additional, Varasi, M., additional, Volpi, D., additional, Zugnoni, P., additional, and Vianello, P., additional

Published
2010
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22. STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125

Author

Brasca, M.G., primary, Amboldi, N., additional, Ballinari, D., additional, Cameron, A.D., additional, Casale, E., additional, Cervi, G., additional, Colombo, M., additional, Colotta, F., additional, Croci, V., additional, Dalessio, R., additional, Fiorentini, F., additional, Isacchi, A., additional, Mercurio, C., additional, Moretti, W., additional, Panzeri, A., additional, Pastori, W., additional, Pevarello, P., additional, Quartieri, F., additional, Roletto, F., additional, Traquandi, G., additional, Vianello, P., additional, Vulpetti, A., additional, and Ciomei, M., additional

Published
2009
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23. STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID

Author

Brasca, M.G., primary, Amboldi, N., additional, Ballinari, D., additional, Cameron, A.D., additional, Casale, E., additional, Cervi, G., additional, Colombo, M., additional, Colotta, F., additional, Croci, V., additional, Dalessio, R., additional, Fiorentini, F., additional, Isacchi, A., additional, Mercurio, C., additional, Moretti, W., additional, Panzeri, A., additional, Pastori, W., additional, Pevarello, P., additional, Quartieri, F., additional, Roletto, F., additional, Traquandi, G., additional, Vianello, P., additional, Vulpetti, A., additional, and Ciomei, M., additional

Published
2009
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27. Indoprofen in Rheumatic Patients with Acute Episodes: A Multicentre Trial

Author

Ambanelli, U, Bassi, G, Bianchi, V, Carcassi, U, Caruso, I, Colombo, B, Goretti, P, Mansoldo, G, Marcolongo, R, Pasero, G, Pellegrini, P, Pipitone, V, Rubegni, M, Todesco, S, Accardo, S, Bedendo, A, Cervi, G, Chérié-Lignière, G, Ciompi, M, Fumagalli, M, Giordano, N, Lavezzari, M, Loizzi, P, Manganelli, P, Perpignano, G, Provvedi, D, and Rossi, R

Abstract

The results are reported of an open multicentre trial in 228 rheumatic patients with flare-ups. Fourteen centres adopting the same investigational protocol collaborated in the study.Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i.v. bolus was followed by 200 mg (1 tablet) t.i.d. Subjective (pain) and objective variables were used for reliable assessment of activity.Marked reduction of pain intensity was already noticeable on day 1 of treatment and was followed by progressive improvement in subjective and objective variables for all the diagnoses considered.According to the patients' own overall assessments, results were good or very good in more than 50% of cases. The best outcomes were obtained in low back pain, acute gout and psoriatic arthritis. At the end of treatment only 7·4% of patients experienced no change or deterioration of symptoms.Adverse reactions, consisting mostly of mild and reversible gastrointestinal disturbances, were reported by 9·2% of patients, but only in 1·8% was treatment discontinued.Indoprofen administered according to the above schedule is an appropriate treatment for acute episodes of rheumatic diseases.

Published
1982
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28. [Staging of lung cancer by computerized tomography: evaluation based on surgical experience]

Author

Pouche', Antonio, Galvani, G., Giulini, Stefano Maria, Tambussi, U., Cervi, G. C., Canini, T., and Tiberio, Giorgio

Subjects
Lung Neoplasms, Carcinoma, Bronchogenic, X-Ray Computed, Diagnosis, Differential, Carcinoma, Bronchogenic, Diagnosis, Differential, Evaluation Studies as Topic, Humans, Neoplasm Staging, Pneumonectomy, Tomography, Tomography, X-Ray Computed
Abstract

One hundred seventy patients with M0 bronchogenic carcinoma were preoperatively evaluated by CT staging whose results were correlated with surgical findings. A number of over and understaging were observed in assessing mediastinal nodes involvement, chest wall invasion, mediastinal pleura and vessels invasion as well as pulmonary vessels involvement. In conclusion, the Authors believe that no patient surgical indication should be excluded on the basis of CT evidence of intrathoracic invasion, in the light of the demonstrated potential for false-positive diagnoses.

Published
1989

30. POLIENTESOPATIA IPEROSTOSANTE DISMETABOLICA

Author

Pellegrini, Pietro, Bazzanini, G, Cervi, G, DELLI GATTI, I, Dovigo, Livio, Govoni, Marcello, LA CORTE, Renato, Menegale, G, Scaramelli, M, and Trotta, Francesco

Published
1986

31. Factors affecting prognosis in acute intestinal ischemia

Author

Giulini, Stefano Maria, Bonardelli, Stefano, Cangiotti, L., Floriani, M., Cervi, G. C., Portolani, Nazario, and Tiberio, Giorgio

Subjects
Adult, Male, Acute Disease, Aged, Female, Humans, Intestines, Ischemia, Mesenteric Vascular Occlusion, Middle Aged, Prognosis, Risk Factors, Splanchnic Circulation
Abstract

The anamnestic, clinical, laboratory, radiological and intraoperative data on 34 consecutive patients affected by acute intestinal ischemia or infarction, caused by superior mesenteric obstructive and nonocclusive pathology were collected and assessed. The aim of this study is the identification of the factors influencing the prognosis which in this disease is still really displeasing, with a mortality of over 90% in many surveys, and 73.5% in this report. The mean age of the 34 patients was 73. Cardiac ischemic disease and or arrhythmias were present in 83.8% of the patients. The most significant prognostic factors were those related to the evolutive stages of the intestinal ischemia. Among the anamnestic ones, the interval between the onset of the symptoms and diagnosis (mortality of 50% if less than or equal to 24 hrs., 86.4% if greater than 24 hrs.). Among the clinical factors, the presence of peritoneal signs was followed by a mortality of 82.3%, in contrast with the 33.3% when the same signs were absent. Also significant was the presence of shock (100% mortality), in contrast with 50% in patients presenting systemic systolic pressure greater than 100 mmHg. Extensive intestinal infarction caused a 100% mortality rate, while early revascularization allowed the survival of 81.8% of the patients treated in the absence of infarction or when irreversible ischemic damage was limited to less than 1 meter of bowel.

Published
1987

32. [Postoperative fistulae in abdominal surgery. Comments on 11 cases]

Author

Portolani, Nazario, Cervi, G. C., Giulini, Stefano Maria, Laffranchini, G., Bonardelli, Stefano, Tambussi, U., and Tiberio, Giorgio

Subjects
Parenteral Nutrition, Postoperative Complications, Fistula, Italy, Incidence, Abdomen, Humans, Total, Parenteral Nutrition, Total, Combined Modality Therapy, Anti-Bacterial Agents, Retrospective Studies
Published
1989

33. [Bilateral breast carcinoma. Considerations on 11 treated cases]

Author

Cervi, G. C., Coniglio, Arianna, Vittoria, A., Marini, G., Giulini, S. M., Biasca, F., and Tiberio, G.

Subjects
Adult, Adenocarcinoma, Scirrhous, Intraductal, Carcinoma, Breast Neoplasms, Adenocarcinoma, Middle Aged, Prognosis, Noninfiltrating, Carcinoma, Intraductal, Noninfiltrating, Scirrhous, Humans, Female, Mastectomy
Published
1983

37. Duodenal metastasis from male breast cancer: a case report and review of the literature

Author

Ferrari Alberto Bruno, Pulcini Giuseppe, Gheza Federico, Vinco Alessandro, Manenti Stefania, Cervi Edoardo, Villanacci Vincenzo, and Cervi Giancarlo

Subjects
Medicine
Abstract

Abstract Introduction Breast cancer is the most frequent type of tumor and the second leading cause of death in women. Metastases are present in nearly 60% of cases at the time of diagnosis with the lymph nodes, skeleton, lungs, brain and liver as the most frequent sites of metastases. Gastrointestinal involvement is rare, present in only 10% of all the cases. There is a very low risk of developing breast cancer in men. Case presentation A 68-year-old man, with a past history of ductal breast cancer, presented with duodenal obstruction. Medical treatment was attempted without success, so he underwent surgery with subtotal gastrectomy and resection of the first portion of the duodenum. Histological examination showed a duodenal metastasis originating from the previous carcinoma of the breast. Five months after surgery, the patient is alive and well. Conclusion Gastrointestinal metastases should be considered in patients with a past history of breast cancer. Surgical treatment should be performed in patients who are symptomatic and in good general condition. To our knowledge this is the only case of a gastrointestinal metastasis from breast carcinoma in a man.

Published
2009
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38. Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients

Author

Giulia Cervi, Domenica Di Costanzo, Andrea Salonia, Linda Vignozzi, Fabio Spreafico, Martina Garuti, Andrea Lenzi, Vincenza Di Stasi, Massimiliano Beccaria, Francesco Inglese, Giuseppe De Donno, Mario Maggi, Tommaso Todisco, Giulia Rastrelli, Graziana Francesca Greco, Giovanni Corona, Elisa Maseroli, Sarah Cipriani, A. Magini, Antonietta Pecoriello, Rastrelli, G., Di Stasi, V., Inglese, F., Beccaria, M., Garuti, M., Di Costanzo, D., Spreafico, F., Greco, G. F., Cervi, G., Pecoriello, A., Magini, A., Todisco, T., Cipriani, S., Maseroli, E., Corona, G., Salonia, A., Lenzi, A., Maggi, M., De Donno, G., and Vignozzi, L.

Subjects
Male, medicine.medical_specialty, Time Factors, Urology, Endocrinology, Diabetes and Metabolism, Down-Regulation, sex hormones, Risk Assessment, Procalcitonin, 03 medical and health sciences, 0302 clinical medicine, Sex hormone-binding globulin, Endocrinology, Predictive Value of Tests, Risk Factors, Internal medicine, Epidemiology, Medicine, Humans, Testosterone, Hospital Mortality, COVID-19, inflammatory markers, mortality, prognosis, Aged, Aged, 80 and over, 030219 obstetrics & reproductive medicine, biology, business.industry, Middle Aged, medicine.disease, Ferritin, Pneumonia, Psychiatry and Mental health, Treatment Outcome, Reproductive Medicine, Predictive value of tests, Cohort, biology.protein, Absolute neutrophil count, Disease Progression, business, Biomarkers
Abstract

Background: The pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical worsening and mortality. Epidemiological data showing a differential impact of SARS-CoV-2 infection on women and men have suggested a potential role for testosterone (T) in determining gender disparity in the SARS-CoV-2 clinical outcomes. Objectives: To estimate the association between T level and SARS-CoV-2 clinical outcomes (defined as conditions requiring transfer to higher or lower intensity of care or death) in a cohort of patients admitted in the respiratory intensive care unit (RICU). Materials and methods: A consecutive series of 31 male patients affected by SARS-CoV-2 pneumonia and recovered in the respiratory intensive care unit (RICU) of the “Carlo Poma” Hospital in Mantua were analyzed. Several biochemical risk factors (ie, blood count and leukocyte formula, C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), ferritin, D-dimer, fibrinogen, interleukin 6 (IL-6)) as well as total testosterone (TT), calculated free T (cFT), sex hormone–binding globulin (SHBG), and luteinizing hormone (LH) were determined. Results: Lower TT and cFT were found in the transferred to ICU/deceased in RICU group vs groups of patients transferred to IM or maintained in the RICU in stable condition. Both TT and cFT showed a negative significant correlation with biochemical risk factors (ie, the neutrophil count, LDH, and PCT) but a positive association with the lymphocyte count. Likewise, TT was also negatively associated with CRP and ferritin levels. A steep increase in both ICU transfer and mortality risk was observed in men with TT&nbsp

Published
2020

39. Self-efficacy in breastfeeding support: A research on italian midwifery students

Author

Prepelita, Tania, Ricchi, Alba, Messina, Marisa Patrizia, Molinazzi, Maria Teresa, Cappadona, Rosaria, Fieschi, Laura, Nespoli, Antonella, Guana, Miriam, Cervi, Gina, Parma, Dila, Mauri, Paola Agnese, Artioli, Giovanna, Banchelli, Federico, Foa, Chiara, Neri, Isabella, Prepelita, T, Ricchi, A, Messina, P, Molinazzi, M, Cappadona, R, Fieschi, L, Nespoli, A, Guana, M, Cervi, G, Parma, D, Mauri, P, Artioli, G, Banchelli, F, Foa, C, and Neri, I

Subjects
breastfeeding, newborn, mother, skills, self-efficacy, midwifery students, breastfeeding, midwifery students, mother, newborn, self-efficacy, skills, Breastfeeding, Midwifery students, Mother, Newborn, Self-efficacy, Skills, Rooming-in Care, Social Support, Socio-culturale, Breastfeeding, Midwifery students, Mother, Newborn, Self-efficacy, Skills, Midwifery, Object Attachment, Mother-Child Relations, Self Efficacy, Kangaroo-Mother Care Method, Breast Feeding, Italy, Surveys and Questionnaires, Humans, Female, MED/47 - SCIENZE INFERMIERISTICHE OSTETRICO-GINECOLOGICHE, Original Article: The Opinions and Needs of Health Professions
Abstract

Background and aim of the study: Maternal breastmilk represents the best nourishment for the newborn baby during its first six months, as it offers several benefits for the health and well-being of babies and mothers. In order to promote, protect and support effectively mother and child during breastfeeding, it is essential for midwives to be properly educated and to acquire highly professionalizing skills. This study aimed to evaluate the level of self-efficacy of the students attending the Degree Course of Midwifery, regarding the support of mother and child in breastfeeding. Method: A questionnaire of 37 items (Blackmanet al, 2015) validated in Italian by Mazzeo Melchionda (2019), was sent on-line to students of ten different Midwifery Degree Courses to assess their level of self-efficacy regarding the management of breastfeeding. Statistical analysis was carried out using statistic software R3.4.3 (The Foundation for Statistical Computing). Results: 158 questionnaires were collected from ten Italian Midwifery Degree Courses. The areas in which students showed a high level of self-efficacy in managing breastfeeding include: the benefits of breastfeeding; the child’s tendency to take the breast within an hour from childbirth and the relevance of skin to skin contact and rooming-in. Low levels of self-efficacy concerned the comfortably breastfeeding in public places and avoiding giving formula to the baby in its first six weeks of life. Conclusions: Generally the students attending Midwifery Degree Courses show a high level of self-efficacy in assisting mothers during breastfeeding and they prove to have a good knowledge of the benefits of breastfeeding to improve the health of mothers and their children. (www.actabiomedica.it).

Published
2020

40. Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Author

Forest W. Arnold, Gustavo Lopardo, Timothy L. Wiemken, Robert Kelley, Paula Peyrani, William A. Mattingly, Charles Feldman, Martin Gnoni, Rosemeri Maurici, Julio A. Ramirez, Forest Arnold, Julio Ramirez, Kwabena Ayesu, Thomas File, Steven Burdette, Stephen Blatt, Marcos Restrepo, Jose Bordon, Peter Gross, Daniel Musher, Thomas Marrie, Karl Weiss, Jorge Roig, Harmut Lode, Tobias Welte, Stephano Aliberti, Francesco Blasi, Roberto Cosentini, Delfino Legnani, Fabio Franzetti, Nicola Montano, Giulia Cervi, Paolo Rossi, Antonio Voza, Belinda Ostrowsky, Alberto Pesci, Stefano Nava, Pierluigi Viale, Vanni Galavatti, Aruj Patricia, Carlos Dimas, Roberto Piro, Claudio Viscoli, Antoni Torres, Vincenzo Valenti, Daniel Portela Ojales, Maria Bodi, Jose Porras, Jordi Rello, Rosario Menendez, Daiana Stolz, Philipp Schuetz, Sebastian Haubitz, James Chalmers, Tom Fardon, Guillermo Benchetrit, Eduardo Rodriguez, Jorge Corral, Jose Gonzalez, Lautaro de Vedia, Carlos Luna, Jorge Martinez, Lucia Marzoratti, Maria Rodriguez, Alejandro Videla, Federico Saavedra, Horacio Lopez, Carlos Victorio, Fernando Riera, Patricio Jimenez, Patricia Fernandez, Maria Parada, Alejandro Díaz Fuenzalida, Raul Riquelme, Manuel Barros, Juan Manuel Luna, Ivan Toala, Guillermo Arbo Oze de Morvil, Ricardo Fernandez, Gonzalo Aiello, Pablo Alvarez, Ana Soca, Federico Arteta, Jose Delgado, Gur Levy, Ludwig Rivero, Benito Rodriguez, Mario Perez Mirabal, Marilyn Mateo, Myrna Mendoza, Arnold, F, Lopardo, G, Wiemken, T, Kelley, R, Peyrani, P, Mattingly, W, Feldman, C, Gnoni, M, Maurici, R, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Viale, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, D, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, A, Riquelme, R, Barros, M, Luna, J, Toala, I, Oze de Morvil, G, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, M, Mateo, M, and Mendoza, M

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Databases, Factual, Community-acquired pneumonia, Antimicrobial treatment, Bacteremia, Kaplan-Meier Estimate, medicine.disease_cause, Severity of Illness Index, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Internal medicine, Streptococcus pneumoniae, medicine, Pneumonia, Bacterial, Humans, 030212 general & internal medicine, Poisson regression, Hospital Mortality, Mortality, Aged, Aged, 80 and over, business.industry, Length of Stay, Middle Aged, medicine.disease, Confidence interval, Anti-Bacterial Agents, Community-Acquired Infections, Pneumonia, Regimen, Treatment Outcome, 030228 respiratory system, Relative risk, symbols, Drug Therapy, Combination, Female, Macrolides, business
Abstract

Background Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide. Materials and methods Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a positive blood culture were categorized based on the presence or absence of a macrolide in their initial antimicrobial regimen, and severity of their CAP. Outcomes included in-hospital all-cause mortality, 30-day mortality, length of stay, and time to clinical stability. Results Among 549 patients with CAP and bacteremia, 247 (45%) were treated with a macrolide and 302 (55%) were not. The primary pathogen was Streptococcus pneumoniae (74%). Poisson regression with robust error variance models were used to compare the adjusted effects of each study group on the outcomes. The unadjusted 30-day mortality was 18.4% in the macrolide group, and 29.6% in the non-macrolide group (adjusted relative risk (aRR)0.81; 95% confidence interval (CI)0.50–1.33; P = 0.41). Unadjusted in-hospital all-cause mortality was 7.3% in the macrolide group, and 18.9% in the non-macrolide group (aRR 0.54, 95% CI 0.30–0.98; P = 0.043). Length of stay and time to clinical stability were not significantly different. Conclusions In-hospital mortality, but not 30-day mortality, was significantly better in the macrolide group. Our data support the use of a macrolide in hospitalized patients with CAP and bacteraemia.

Published
2018

41. Bicyclic carbohydrate-derived scaffolds for combinatorial libraries

Author

Francesco Nicotra, Francesco Peri, Giovanni Cervi, Carlo Battistini, Cesare Gennari, Cervi, G, Peri, F, Gennari, C, Battistini, C, and Nicotra, F

Subjects
Male, Stereochemistry, Molecular Sequence Data, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Ether, Biochemistry, Chemical synthesis, Bridged Bicyclo Compounds, chemistry.chemical_compound, Cell Line, Tumor, Amide, CHIM/06 - CHIMICA ORGANICA, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Monosaccharide, Molecular Biology, Cell Proliferation, Pyrans, chemistry.chemical_classification, Molecular Structure, Bicyclic molecule, Organic Chemistry, Prostatic Neoplasms, Carbohydrate, Sulfonamide, Glucose, Carbohydrate Sequence, chemistry, Aldose, carbohydrate, scaffolds, Colonic Neoplasms, Molecular Medicine, Drug Screening Assays, Antitumor, combinatorial chemistry
Abstract

A bicyclic scaffold derived from the natural monosaccharide d-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-3' position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.

Published
2006
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42. Synthesis of a β-carboline scaffold properly functionalysed for the generation of libraries of bioactive compounds

Author

Gianluca Papeo, Francesco Nicotra, Eduard R. Felder, Giovanni Cervi, Alexandre Orsato, Barbara La Ferla, Cristiano Zona, LA FERLA, B, Orsato, A, Zona, C, Cervi, G, Papeo, G, Felder, E, and Nicotra, F

Subjects
Indole test, Chemoselectivity, Scaffold, Chemistry, Cyclization, Indole, β-carboline, Organic Chemistry, CHIM/06 - CHIMICA ORGANICA, Organic chemistry, Combinatorial chemistry, Catalysis
Abstract

In this work we report the synthesis of the 1-oxo-1,2,3,4-tetrahydro-β-carboline scaffold with two regioselectively functionalizable positions, starting from a readily available indole precursor.

Published
2010

43. Cellular non-specific interstitial pneumonia as a pulmonary manifestation of primary biliary cirrhosis

Author

Fabrizio Luppi, Francesco Falco, Lucia Spaggiari, A. Roggeri, Giulio Rossi, Domenico Corradi, Alberto Cavazza, Giulia Cervi, Cavazza, A, Rossi, G, Corradi, D, Luppi, F, Cervi, G, Spaggiari, L, Falco, F, and Roggeri, A

Subjects
Autoimmune disease, Pathology, medicine.medical_specialty, Granuloma, Non-specific interstitial pneumonia, business.industry, Liver Cirrhosis, Biliary, Intrahepatic bile ducts, Middle Aged, medicine.disease, digestive system, digestive system diseases, Pathology and Forensic Medicine, Primary biliary cirrhosis, medicine, Humans, Female, Cellular non-specific interstitial pneumonia, primary biliary cirrhosis, business, Lung Diseases, Interstitial
Abstract

Sir,Primary biliary cirrhosis (PBC) is a slowly progressive autoimmune disease characterised by granulomatous destruction of intrahepatic bile ducts. Extrahepatic manifestations are frequent and in...

Published
2010

44. Isomeric Speciation of Bisbenzoxazine Intermediates by Ion Spectroscopy and Ion Mobility Mass Spectrometry.

Author

Ribeiro FWM, Silva-Oliveira D, Cervi G, Koyanagui ED, and Correra TC

Abstract

Bisbenzoxazines ( BisBz ) are a relevant model for the diverse bifunctional benzoxazines that are used to increase the polybenzoxazines cross-linking extensions and modulate the final resin properties for various usages. The presence of side products and intermediates during monomer formation can influence the resin characteristics by inducing chain termination and ramifications, affecting the polymerization and cure processes. This work investigated the diverse isomeric intermediates and side products that are present during the BisBz formation from bisphenol A, aniline, and formaldehyde by ion mobility coupled to tandem mass spectrometry (MS/MS) and ion spectroscopy techniques. The species detected in this work suggest that these multifunctional phenols open diverse concurrent reaction pathways based on two main reactive steps: (i) the imine/iminium phenol attack to form a phenylamino intermediate and (ii) the formaldehyde attack followed by dehydration to form the oxazine ring. The species observed also support previous studies of the benzoxazine formation mechanism and showcase the application of advanced analytical techniques in studying complex chemical systems., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Published
2024
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45. 1-Iodoglycal: A Versatile Intermediate for the Synthesis of d-Glyco Amides and Esters Employing Carbonylative Cross-Coupling Reaction.

Author

Hornink MM, Toledo MFZJ, Pimenta DC, Paschoalin C, Silva PM, Figlino GE, Aguiar E, Cervi G, Ribeiro FWM, Carita Correra T, Ferry A, and Stefani HA

Abstract

In this study, we present the development of two catalytic processes: a Pd-PEPPSI-catalyzed aminocarbonylation and a Pd(OAc) 2 -Xantphos-catalyzed alkoxycarbonylation of d-glycals, utilizing carbonylative cross-coupling reactions. We explored successfully various types of aromatic amines, as well as alkyl amines and amino acids, to synthesize new d-glycal amides. However, we observed limitations in the reactivity of alkyl and heteroaromatic amines. The processes enabled the synthesis of 20 novel C1-branched glycoamides and 7 new d-gluco esters., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Published
2024
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46. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors.

Author

Cervi G, D'Alessio R, Bindi S, Buffa L, Burocchi A, Canevari G, Modugno M, Motto I, Saturno G, and Orsini P

Subjects
Humans, Syk Kinase metabolism, Intracellular Signaling Peptides and Proteins metabolism, Signal Transduction, Phosphorylation, Protein Kinase Inhibitors therapeutic use, Protein-Tyrosine Kinases, Hematologic Neoplasms drug therapy, Pyrimidines
Abstract

Spleen tyrosine kinase (Syk) is a key signal transduction mediator of the B cell receptor (BCR) signaling pathway. Abnormal BCR signaling plays a key role in initiation and development of B-cell-derived hematological malignancies, therefore, Syk represents a potential target for inhibiting the BCR signaling resulting in a therapeutic effect in these cancers. Herein, we describe a novel series of SYK inhibitors with 4-(3'-pyrazolyl)-2-amino-pyrimidine scaffold. Extensive study of structure-activity relationships led to the identification of 1 (NMS-0963), a highly potent Syk inhibitor (IC 50  = 3 nM) endowed with high selectivity within a panel of tested kinases and high antiproliferative activity in SYK-dependent BaF3-TEL/SYK cells and in other BCR-dependent hematological tumor cell lines. Additionally, 1 effectively inhibited Syk phosphorylation and downstream signaling mediators of the BCR in treated cells. In in vivo pharmacokinetics studies, 1, displayed good pharmacokinetics properties, with linear exposure with dose and excellent oral bioavailability. These findings suggest that 1 is a promising new Syk inhibitor for treating BCR-dependent hematological cancers., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Masson SAS. All rights reserved.)

Published
2024
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47. A novel diselenide attenuates the carrageenan-induced inflammation by reducing neutrophil infiltration and the resulting tissue damage in mice.

Author

Lessa TLADS, Correia TML, Santos TCD, da Silva RP, Silva BPD, Cavallini MCM, Rocha LS, Souza Peixoto A, Cugnasca BS, Cervi G, Correra TC, Gonçalves AC, Festuccia WTL, Cunha TM, Yatsuda R, de Magalhães ACM, Dos Santos AA, Meotti FC, and Queiroz RF

Subjects
Animals, Mice, Humans, Male, Neutrophils drug effects, Neutrophils metabolism, Edema drug therapy, Edema chemically induced, Peroxidase metabolism, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Organoselenium Compounds pharmacology, Organoselenium Compounds therapeutic use, Hypochlorous Acid, Carrageenan, Inflammation drug therapy, Inflammation chemically induced, Neutrophil Infiltration drug effects
Abstract

Selenium-containing compounds have emerged as promising treatment for redox-based and inflammatory diseases. This study aimed to investigate the in vitro and in vivo anti-inflammatory activity of a novel diselenide named as dibenzyl[diselanediyIbis(propane-3-1diyl)] dicarbamate (DD). DD reacted with HOCl ( k  = 9.2 x 10 7 M -1 s -1 ), like glutathione ( k  = 1.2 x 10 8 M -1 s -1 ), yielding seleninic and selenonic acid derivatives, and it also decreased HOCl formation by activated human neutrophils (IC 50 =4.6 μM) and purified myeloperoxidase (MPO) (IC 50 =3.8 μM). However, tyrosine, MPO-I and MPO-II substrates, did not restore HOCl formation in presence of DD. DD inhibited the oxidative burst in d HL-60 cells with no toxicity up to 25 µM for 48h. Next, an intraperitoneal administration of 25, 50, and 75 mg/kg DD decreased total leukocyte, neutrophil chemotaxis, and inflammation markers (MPO activity, lipid peroxidation, albumin exudation, nitrite, TNF-α, IL-1β, CXCL1/KC, and CXCL2/MIP-2) on a murine model of carrageenan-induced peritonitis. Likewise, 50 mg/kg DD (i.p.) decreased carrageenan-induced paw edema over 5h. Histological and immunohistochemistry analyses of the paw tissue showed decreased neutrophil count, edema area, and MPO, carbonylated, and nitrated protein staining. Furthermore, DD treatment decreased the fMLP-induced chemotaxis of human neutrophils (IC 50 =3.7 μM) in vitro with no toxicity. Lastly, DD presented no toxicity in a single-dose model using mice (50 mg/kg, i.p.) over 15 days and in Artemia salina bioassay (50 to 2000 µM), corroborating findings from in silico toxicological study. Altogether, these results demonstrate that DD attenuates carrageenan-induced inflammation mainly by reducing neutrophil migration and the resulting damage from MPO-mediated oxidative burst.

Published
2024
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48. Up-regulation by overexpression of c-MET in fibroblastic foci of usual interstitial pneumonia.

Author

Melocchi L, Cervi G, Sartori G, Gandolfi L, Jocollé G, Cavazza A, and Rossi G

Subjects
Humans, Lung pathology, Retrospective Studies, Up-Regulation, Idiopathic Pulmonary Fibrosis genetics, Idiopathic Pulmonary Fibrosis diagnosis, Idiopathic Pulmonary Fibrosis pathology, Lung Diseases, Interstitial genetics, Lung Diseases, Interstitial pathology, Lung Neoplasms pathology, Pneumonia pathology
Abstract

Background: Usual interstitial pneumonia (UIP) is the radiologic and histologic hallmark of idiopathic pulmonary fibrosis (IPF) and the commonest histologic pattern of other progressive fibrosing interstitial lung diseases (e.g., fibrotic hypersensitivity pneumonia). Analogous to lung cancer, activation of epithelial-to-mesenchymal transition (EMT) is one of the main molecular pathways recently identified by transcriptomic studies in IPF. Fibroblastic foci (FF) are considered the active/trigger component of UIP pattern. The proto-oncogene C-MET is a key gene among molecules promoting EMT against which several inhibitors are currently available or promising in ongoing studies on lung cancer., Methods: Twenty surgical cases of diffuse fibrosing interstitial lung diseases (fILD) with UIP pattern and FF-rich (17 IPF and 3 patients with fibrotic hypersensitivity pneumonia, fHP) were retrospectively selected. FF were manually microdissected and analysed for c-MET gene alterations (FISH amplification and gene hot-spot mutations Sanger sequencing) and tested with a c-MET companion diagnostic antibody (clone SP44 metmab) by immunohistochemistry., Results: FF are characterized by upregulation of c-MET as shown by overexpression of the protein in 80% of cases, while no gene amplification by FISH or mutations were detected. C-MET upregulation of FF was observed either in IPF and fHP, with a tropism for the epithelial cell component only., Conclusion: Upregulation of c-MET in FF of ILD with UIP pattern further confirms the key role of the proto-oncogene c-MET in its pathogenesis, possibly representing an interesting and easily-detectable molecular target for selective therapy using specific inhibitors in future clinical trials, similar to lung cancer. It is reasonable to speculate that molecular alterations in FF can also be detected in FF by transbronchial cryobiopsy., (Copyright © 2023 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.)

Published
2023
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49. Convalescent Plasma for Hospitalized COVID-19 Patients: A Single-Center Experience.

Author

Franchini M, Glingani C, Donno G, Lucchini G, Beccaria M, Amato M, Castelli GP, Bianciardi L, Pagani M, Ghirardini M, Puma G, Presciuttini B, Costantino MT, Frigato M, Crosato V, Tiecco G, Mulè A, Papalia DA, Inglese F, Spreafico F, Garuti M, Pecoriello A, Cervi G, Greco G, Galavotti V, Santini T, Berselli A, Montalto C, Bertoletti R, Bellometti SA, Capuzzo E, Benazzi D, Grisolia G, Pajola F, Stradoni R, Zani M, Verzola A, Codeluppi V, Vesentini S, Bellocchio E, Candini M, Ambrosi G, Carandina F, Scarduelli C, Reggiani A, Casari S, and On Behalf Of Convalescent Plasma Study Group

Abstract

In Winter 2020, Italy, and in particular the Lombardy region, was the first country in the Western hemisphere to be hit by the COVID-19 pandemic. Plasma from individuals recovered from COVID-19 (COVID-19 convalescent plasma, CCP) was the first therapeutic tool adopted to counteract the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In this retrospective cohort study, we report the experience of the city hospital of Mantua, Lombardy region, on the compassionate use of CCP in patients hospitalized for severe COVID-19. Between April 2020 and April 2021, 405 consecutive COVID-19 patients received 657 CCP units with a median anti-SARS-CoV-2 neutralizing antibody (nAb) titer of 160 (interquartile range (IQR), 80−320). Their median age was 68 years (IQR, 56−78 years), and 62% were males. At enrollment, 55% of patients had an increased body mass index (BMI), and 25.6% had at least three comorbidities. The 28-day crude mortality rate was 12.6% (51/405). Young age (<68 years), mild disease (admission to low-intensity departments) and early treatment (<7 days from symptoms onset) with high nAb titer (≥320) CCP were found as independently associated with a favorable response to CCP treatment. No safety concerns were recorded, with a rate of CCP-related adverse reactions (all of mild intensity) of 1.3%. In our real-life experience, the first in the western world, early administration of high-titer CCP was a safe and effective treatment for hospitalized COVID-19 patients.

Published
2022
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50. Pulmonary embolism in patients with severe COVID-19 treated with intermediate- to full-dose enoxaparin: A retrospective study.

Author

Scarduelli C, Inglese F, Beccaria M, Spreafico F, Garuti M, Pecoriello A, Cervi G, Greco G, Scarduelli S, Lucchini G, De Donno G, and Borghi C

Subjects
Anticoagulants adverse effects, Enoxaparin therapeutic use, Humans, Retrospective Studies, SARS-CoV-2, COVID-19, Pulmonary Embolism diagnostic imaging, Pulmonary Embolism drug therapy, Pulmonary Embolism epidemiology, Venous Thromboembolism
Abstract

Coronavirus disease (COVID-19) may predispose patients to pulmonary embolism (PE), despite standard thromboprophylaxis. Our retrospective study aimed to report the prevalence of PE in patients with COVID-19 and severe respiratory failure (SRF) treated with intermediate- to full-dose enoxaparin. We analyzed data from patients with COVID-19 pneumonia and SRF admitted to our Respiratory Intensive Care Unit (RICU) from February 27 to April 20, 2020. All patients received at least intermediate-dose enoxaparin (40 mg twice daily). Computed tomography pulmonary angiography (CTPA) was used to detect PE. Ninety-two patients with COVID-19 pneumonia and SRF were admitted to our RICU. Twenty-two patients underwent CTPA (24 %), 11 of whom had PEs (12%). We hypothesize that the enoxaparin treatment may be responsible for the lower prevalence of PE as compared to previous reports of similar patients, even if our report had several limitations, mainly the small sample size.

Published
2021
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