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154 results on '"Cervantes, Jorge L."'

4. Effect of the Crystalline Phase Type on the Thermoluminescent Response of ZrO2 Due to Different Synthesis Methods.

Author

Leon, Manuel, Montes, Eduardo, Elias, Janet A., Cervantes, Jorge L., Diaz-Torres, Luis A., Sosa, Modesto A., and Vallejo, M. A.

Subjects
SCINTILLATORS, ZIRCONIUM oxide, NANOPARTICLE size, SCANNING electron microscopy, X-ray diffraction, PHOTONS
Abstract

ZrO2 samples were obtained using three different synthesis methods (Calcination, Co-precipitation and Hydrothermal). The samples were characterized to analyze the effect of the crystalline phase on their thermoluminescent (TL) and photoluminescent (PL) responses. The ZrO2 phase was analyzed by X-Ray diffraction (XRD) and Raman. Nanoparticle size distribution was obtained by scanning electron microscopy (SEM). For optical analysis, characterizations included absorbance measurements, where samples exhibited modifications in color centers, PL emission and experimental fluorescence lifetime decay ( τ exp) measurements. Additionally, their TL response was studied under UV (245 nm and 385 nm), and 6 MV photon energy from LINAC excitation. The obtained results show the improvement of TL and PL properties due to ZrO2 phase while an amorphous ZrO2 synthesized by hydrothermal method is an excellent prospect to be used as TL material and it may be a promising scintillator material at 254 nm. ZrO2 samples were obtained using three different synthesis methods (Calcination, Co-precipitation and Hydrothermal). The samples were then characterized, TL response was studied under UV (245 and 385 nm), and 6 MV photon energy from LINAC excitation showing an improvement of TL and PL properties due to ZrO2 phase. Amorphous ZrO2 synthesized by hydrothermal method has great potential as a TL material and it may be a promising scintillator material at 254 nm. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy)

Author

Sadofsky, Laura R., Hayman, Yvette A., Vance, Jesse, Cervantes, Jorge L., Fraser, Simon D., Wilkinson, Holly N., and Williamson, James D.

Subjects
Gene expression -- Research, Viral antibodies -- Research, Macrophages -- Research, Phagocytosis -- Research, Antibodies -- Research, Health
Abstract

Purpose There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In this study, we characterise a human macrophage cell line, derived from THP-1 cells, and compare its phenotype to the THP-1 cells. Methods THP-1 cells with and without mitogenic stimulation were compared to the newly derived macrophage-like cell line (Daisy) using microscopy, flow cytometry, phagocytosis assays, antigen binding assays and gene microarrays. Results We show that the cell line grows predominantly in an adherent monolayer. A panel of antibodies were chosen to investigate the cell surface phenotype of these cells using flow cytometry. Daisy cells expressed more CD11c, CD80, CD163, CD169 and CD206, but less CD14 and CD11b compared with mitogen-stimulated THP-1 cells. Unlike stimulated THP-1 cells which were barely able to bind immune complexes, Daisy cells showed large amounts of immune complex binding. Finally, although not statistically significant, the phagocytic ability of Daisy cells was greater than mitogen-stimulated THP-1 cells, suggesting that the cell line is more similar to mature macrophages. Conclusions The observed phenotype suggests that Daisy cells are a good model of human macrophages with a phenotype similar to human alveolar macrophages., Author(s): Laura R. Sadofsky [sup.1] , Yvette A. Hayman [sup.2] , Jesse Vance [sup.3] , Jorge L. Cervantes [sup.3] , Simon D. Fraser [sup.2] , Holly N. Wilkinson [sup.1] , [...]

Published
2019
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11. TLR8

Author

Cervantes, Jorge L., Maulén, Nancy, Chai, Han-Ha, and Choi, Sangdun, editor

Published
2018
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41. Macrophage mediated recognition and clearance ofBorrelia burgdorferinelicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation

Author

Benjamin, Sarah J., primary, Hawley, Kelly L., additional, Vera-Licona, Paola, additional, La Vake, Carson J., additional, Cervantes, Jorge L., additional, Burns, Rachel, additional, Luo, Oscar, additional, Ruan, Yijun, additional, Caimano, Melissa J., additional, Radolf, Justin D., additional, and Salazar, Juan C., additional

Published
2019
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43. IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages

Author

Hawley, Kelly L., primary, Cruz, Adriana R., additional, Benjamin, Sarah J., additional, La Vake, Carson J., additional, Cervantes, Jorge L., additional, LeDoyt, Morgan, additional, Ramirez, Lady G., additional, Mandich, Daniza, additional, Fiel-Gan, Mary, additional, Caimano, Melissa J., additional, Radolf, Justin D., additional, and Salazar, Juan C., additional

Published
2017
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44. Correction: Corrigendum: Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4

Author

Qiu, Zhijuan, primary, Cervantes, Jorge L., additional, Cicek, Basak B., additional, Mukherjee, Subhajit, additional, Venkatesh, Madhukumar, additional, Maher, Leigh A., additional, Salazar, Juan C., additional, Mani, Sridhar, additional, and Khanna, Kamal M., additional

Published
2017
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46. The Microbiome at the Pulmonary Alveolar Niche: How It Affects the Human Innate Response against Mycobacterium tuberculosis

Author

Adami, Alexander J. and Cervantes, Jorge L.

Subjects
Microbiota, Antitubercular Agents, chemical and pharmacologic phenomena, Comorbidity, Mycobacterium tuberculosis, respiratory system, Article, Immunity, Innate, Pulmonary Alveoli, Treatment Outcome, Cellular Microenvironment, Risk Factors, Host-Pathogen Interactions, Macrophages, Alveolar, Humans, Tuberculosis, Pulmonary
Abstract

Advances in next generation sequencing (NGS) technology have provided the tools to comprehensively and accurately characterize the microbial community in the respiratory tract in health and disease. The presence of commensal and pathogenic bacteria has been found to have important effects on the lung immune system. Until relatively recently, the lung has received less attention compared to other body sites in terms of microbiome characterization, and its study carries special technological difficulties related to obtaining reliable samples as compared to other body niches. Additionally, the complexity of the alveolar immune system, and its interactions with the lung microbiome, are only just beginning to be understood. Amidst this complexity sits Mycobacterium tuberculosis (Mtb), one of humanity's oldest nemeses and a significant public health concern, with millions of individuals infected with Mtb worldwide. The intricate interactions between Mtb, the lung microbiome, and the alveolar immune system are beginning to be understood, and it is increasingly apparent that improved treatment of Mtb will only come through deep understanding of the interplay between these three forces. In this review, we summarize our current understanding of the lung microbiome, alveolar immunity, and the interaction of each with Mtb.

Published
2015

47. Early Impact of the COVID-19 Pandemic on Congenital Heart Surgery Programs Across the World: Assessment by a Global Multi-Societal Consortium

Author

Protopapas, Eleftherios M., Rito, Mauro Lo, Vida, Vladimiro L., Sarris, George E., Tchervenkov, Christo I., Maruszewski, Bohdan J., Tobota, Zdzislaw, Zheleva, Bistra, Zhang, Hao, Jacobs, Jeffery P., Dearani, Joseph A., Stephens, Elizabeth H., Tweddell, James S., Sandoval, Nestor F., Bacha, Emile A., Austin, Erle H., Sakamoto, Kisaburo, Talwar, Sachin, Kurosawa, Hiromi, Halees, Zohair Y. Al, Jatene, Marcello B., Iyer, Krishna S., Lee, Cheul, Sharma, Rajesh, Hirata, Yasutaka, Edwin, Frank, Cervantes, Jorge L., O'Brien, James, St. Louis, James, and Kirklin, James K.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic currently gripping the globe is impacting the entire health care system with rapidly escalating morbidities and mortality. Although the infectious risk to the pediatric population appears low, the effects on children with congenital heart disease (CHD) remain poorly understood. The closure of congenital heart surgery programs worldwide to address the growing number of infected individuals could have an unintended impact on future health for COVID-19-negative patients with CHD. Pediatric and congenital heart surgeons, given their small numbers and close relationships, are uniquely positioned to collectively assess the impact of the pandemic on surgical practice and care of children with CHD. We present the results of an international survey sent to pediatric and congenital heart surgeons characterizing the early impact of COVID-19 on the care of patients with CHD.

Published
2020
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50. The phagosome: Meeting point of the Myddosome, NLRs, and degraded Borrelia burgdorferi

Author

Cervantes, Jorge L., primary, Benjamin, Sarah J., additional, Chang, Yuxiao, additional, Luo, Junhong, additional, La Vake, Carson J., additional, Hawley, Kelly L., additional, Caimano, Melissa, additional, Vera-Licona, Paola, additional, Laubenbacher, Reinhard, additional, Ruan, Yijun, additional, Radolf, Justin, additional, and Salazar, Juan C., additional

Published
2016
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