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475 results on '"Ceroni, Francesca"'

9. Embrace experimentation in biosecurity governance

Author

Evans, Sam Weiss, Beal, Jacob, Berger, Kavita, Bleijs, Diederik A, Cagnetti, Alessia, Ceroni, Francesca, Epstein, Gerald L, Garcia-Reyero, Natàlia, Gillum, David R, Harkess, Graeme, Hillson, Nathan J, Hogervorst, Petra AM, Jordan, Jacob L, Lacroix, Geneviève, Moritz, Rebecca, ÓhÉigeartaigh, Seán S, Palmer, Megan J, and van Passel, Mark WJ

Subjects
Animals, Biomedical Research, Containment of Biohazards, Humans, General Science & Technology
Abstract

We must rethink and test assumptions about relationships among biological research, security, and society

Published
2020

10. In-plane Behavior of Iron-Framed Masonry Panels: Numerical Analyses

Author

Celano, Thomas, Argiento, Luca, Ceroni, Francesca, Casapulla, Claudia, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, and Mazzolani, Federico M., editor

Published
2022
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11. Bond Behavior of Steel Plates Externally Bonded on Concrete Elements

Author

Ciampa, Elena, Ceroni, Francesca, Pecce, Maria Rosaria, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Ilki, Alper, editor, Ispir, Medine, editor, and Inci, Pinar, editor

Published
2022
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16. On the Dynamic Performance of the Santa Maria Maddalena Church, Ischia Island (Italy): Numerical and Experimental Comparative Analysis

Author

Casapulla, Claudia, Celano, Thomas, Rainieri, Carlo, Fabbrocino, Giovanni, Ceroni, Francesca, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Rainieri, Carlo, editor, Fabbrocino, Giovanni, editor, Caterino, Nicola, editor, Ceroni, Francesca, editor, and Notarangelo, Matilde A., editor

Published
2021
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19. Initial cell density encodes proliferative potential in cancer cell populations

Author

Bena, Chiara Enrico, Del Giudice, Marco, Grob, Alice, Gueudré, Thomas, Miotto, Mattia, Gialama, Dimitra, Osella, Matteo, Turco, Emilia, Ceroni, Francesca, De Martino, Andrea, and Bosia, Carla

Subjects
Quantitative Biology - Quantitative Methods, Physics - Biological Physics, Quantitative Biology - Populations and Evolution, 92-05, 92C30, 92B05
Abstract

Individual cells exhibit specific proliferative responses to changes in microenvironmental conditions. Whether such potential is constrained by the cell density throughout the growth process is however unclear. Here, we identify a theoretical framework that captures how the information encoded in the initial density of cancer cell populations impacts their growth profile. By following the growth of hundreds of populations of cancer cells, we found that the time they need to adapt to the environment decreases as the initial cell density increases. Moreover, the population growth rate shows a maximum at intermediate initial densities. With the support of a mathematical model, we show that the observed interdependence of adaptation time and growth rate is significantly at odds both with standard logistic growth models and with the Monod-like function that governs the dependence of the growth rate on nutrient levels. Our results (i) uncover and quantify a previously unnoticed heterogeneity in the growth dynamics of cancer cell populations; (ii) unveil how population growth may be affected by single-cell adaptation times; (iii) contribute to our understanding of the clinically-observed dependence of the primary and metastatic tumor take rates on the initial density of implanted cancer cells., Comment: 25 pages (13 main text + 12 supplementary information), 16 figures (5 main text + 11 supplementary information). Comments welcome

Published
2017
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23. Influence of different set-up parameters on the bond behavior of FRCM composites

Author

Bellini, Alessandro, Aiello, Maria Antonietta, Bencardino, Francesco, de Carvalho Bello, Claudia Brito, Castori, Giulio, Cecchi, Antonella, Ceroni, Francesca, Corradi, Marco, D'Antino, Tommaso, De Santis, Stefano, Fagone, Mario, de Felice, Gianmarco, Leone, Marianovella, Lignola, Gian Piero, Napoli, Annalisa, Nisticò, Mattia, Poggi, Carlo, Prota, Andrea, Ranocchiai, Giovanna, Realfonzo, Roberto, Sacco, Elio, and Mazzotti, Claudio

Published
2021
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26. Multiplexed Transactivation of Mammalian Cells Using dFnCas12a-VPR

Author

Ceroni, Francesca, Polizzi, Karen, Bryson, James W., Rosser, Susan J., Ceroni, Francesca, Polizzi, Karen, Bryson, James W., and Rosser, Susan J.

Abstract

CRISPR activation provides an invaluable tool for experimental biologists to convert correlations into causation by directly observing phenotypic changes upon targeted changes in gene expression. With few exceptions, most diseases are caused by complex polygenic interactions, with multiple genes contributing to define the output of a gene network. As such researchers are increasingly interested in tools that can offer not only control but also the capacity to simultaneously upregulate multiple genes. The adaptation of CRISPR/Cas12a has provided a system especially suited to the tightly coordinated overexpression of multiple targeted genes. Here we describe an approach to test for active targeting crRNAs for dFnCas12a-VPR, before proceeding to generate and validate longer crRNA arrays for multiplexed targeting of genes of interest., CRISPR activation provides an invaluable tool for experimental biologists to convert correlations into causation by directly observing phenotypic changes upon targeted changes in gene expression. With few exceptions, most diseases are caused by complex polygenic interactions, with multiple genes contributing to define the output of a gene network. As such researchers are increasingly interested in tools that can offer not only control but also the capacity to simultaneously upregulate multiple genes. The adaptation of CRISPR/Cas12a has provided a system especially suited to the tightly coordinated overexpression of multiple targeted genes. Here we describe an approach to test for active targeting crRNAs for dFnCas12a-VPR, before proceeding to generate and validate longer crRNA arrays for multiplexed targeting of genes of interest.

Published
2024

29. Nucleated synthetic cells with genetically driven intercompartment communication.

Author

Ioannou, Ion A., Monck, Carolina, Ceroni, Francesca, Brooks, Nicholas J., Kuimova, Marina K., and Elani, Yuval

Subjects
ARTIFICIAL cells, MEMBRANE proteins, BIOLOGICAL membranes, SYNTHETIC biology, PROTEIN expression
Abstract

Eukaryotic cells are characterized by multiple chemically distinct compartments, one of the most notable being the nucleus. Within these compartments, there is a continuous exchange of information, chemicals, and signaling molecules, essential for coordinating and regulating cellular activities. One of the main goals of bottom-up synthetic biology is to enhance the complexity of synthetic cells by establishing functional compartmentalization. There is a need to mimic autonomous signaling between compartments, which in living cells, is often regulated at the genetic level within the nucleus. This advancement is key to unlocking the potential of synthetic cells as cell models and as microdevices in biotechnology. However, a technological bottleneck exists preventing the creation of synthetic cells with a defined nucleus-like compartment capable of genetically programmed intercompartment signaling events. Here, we present an approach for creating synthetic cells with distinct nucleus-like compartments that can encapsulate different biochemical mixtures in discrete compartments. Our system enables in situ protein expression of membrane proteins, enabling autonomous chemical communication between nuclear and cytoplasmic compartments, leading to downstream activation of enzymatic pathways within the cell. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Engineered Bacteria as Living Biosensors in Dermal Tattoos.

Author

Allen, Matthew E., Kamilova, Elina, Monck, Carolina, Ceroni, Francesca, Hu, Yubing, Yetisen, Ali K., and Elani, Yuval

Subjects
EMPLOYABILITY, SMALL molecules, BIOSENSORS, MICROFLUIDICS, DATA analytics, SYNTHETIC biology
Abstract

Dermal tattoo biosensors are promising platforms for real‐time monitoring of biomarkers, with skin used as a diagnostic interface. Traditional tattoo sensors have utilized small molecules as biosensing elements. However, the rise of synthetic biology has enabled the potential employment of engineered bacteria as living analytical tools. Exploiting engineered bacterial sensors will allow for potentially more sensitive detection across a broad biomarker range, with advanced processing and sense/response functionalities using genetic circuits. Here, the interfacing of bacterial biosensors as living analytics in tattoos is shown. Engineered bacteria are encapsulated into micron‐scale hydrogel beads prepared through scalable microfluidics. These biosensors can sense both biochemical cues (model biomarkers) and biophysical cues (temperature changes, using RNA thermometers), with fluorescent readouts. By tattooing beads into skin models and confirming sensor activity post‐tattooing, our study establishes a foundation for integrating bacteria as living biosensing entities in tattoos. [ABSTRACT FROM AUTHOR]

Published
2024
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38. NSM Systems

Author

Sena-Cruz, José, Barros, Joaquim, Bianco, Vincenzo, Bilotta, Antonio, Bournas, Dionysios, Ceroni, Francesca, Dalfré, Glaucia, Kotynia, Renata, Monti, Giorgio, Nigro, Emilio, Triantafillou, Thanasis, Pellegrino, Carlo, editor, and Sena-Cruz, José, editor

Published
2016
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39. Special Problems

Author

Ceroni, Francesca, Pecce, Marisa, Carloni, Christian, Leusmann, Thorsten, Budelmann, Harald, Nigro, Emidio, Bilotta, Antonio, Barros, Joaquim, Costa, Inês, Lignola, Gian Piero, Napoli, Annalisa, Realfonzo, Roberto, Pellegrino, Carlo, editor, and Sena-Cruz, José, editor

Published
2016
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40. Bond Between EBR FRP and Concrete

Author

Mazzotti, Claudio, Bilotta, Antonio, Carloni, Christian, Ceroni, Francesca, D’Antino, Tommaso, Nigro, Emidio, Pellegrino, Carlo, Pellegrino, Carlo, editor, and Sena-Cruz, José, editor

Published
2016
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45. Resource-aware construct design in mammalian cells

Author

Di Blasi, Roberto, primary, Pisani, Mara, additional, Tedeschi, Fabiana, additional, Marbiah, Masue M., additional, Polizzi, Karen, additional, Furini, Simone, additional, Siciliano, Velia, additional, and Ceroni, Francesca, additional

Published
2023
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