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1. Patient Preference Studies for Advanced Prostate Cancer Treatment Along the Medical Product Life Cycle: Systematic Literature Review

Author

Menges D, Piatti MC, Cerny T, and Puhan MA

Subjects
patient preferences, medical product life cycle, preference research, benefit-harm assessment, patient-centered care, prostate cancer, systematic review, Medicine (General), R5-920
Abstract

Dominik Menges,1 Michela C Piatti,1 Thomas Cerny,2,3 Milo A Puhan1 1Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH), Zurich, Switzerland; 2Foundation Board, Cancer Research Switzerland (Krebsforschung Schweiz KFS), Bern, Switzerland; 3Human Medicines Expert Committee (HMEC), Swissmedic, Bern, SwitzerlandCorrespondence: Dominik Menges, Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich (UZH), Hirschengraben 84, Zurich, CH-8001, Switzerland, Tel +41 44 634 46 15, Email dominik.menges@uzh.chBackground: Patient preference studies can inform decision-making across all stages of the medical product life cycle (MPLC). The treatment landscape for advanced prostate cancer (APC) treatment has substantially changed in recent years. However, the most patient-relevant aspects of APC treatment remain unclear. This systematic review of patient preference studies in APC aimed to summarize the evidence on patient preferences and patient-relevant aspects of APC treatments, and to evaluate the potential contribution of existing studies to decision-making within the respective stages of the MPLC.Methods: We searched MEDLINE and EMBASE for studies evaluating patient preferences related to APC treatment up to October 2020. Two reviewers independently performed screening, data extraction and quality assessment in duplicate. We descriptively summarized the findings and analyzed the studies regarding their contribution within the MPLC using an analytical framework.Results: Seven quantitative preference studies were included. One study each was conducted in the marketing approval and the health technology assessment (HTA) and reimbursement stage, and five were conducted in the post-marketing stage of the MPLC. While almost all stated to inform clinical practice, the specific contributions to clinical decision-making remained unclear for almost all studies. Evaluated attributes related to benefits, harms, and other treatment-related aspects and their relative importance varied relevantly between studies. All studies were judged of high quality overall, but some methodological issues regarding sample selection and the definition of patient-relevant treatment attributes were identified.Conclusion: The most patient-relevant aspects regarding the benefits and harms of APC treatment are not yet established, and it remains unclear which APC treatments are preferred by patients. Findings from this study highlight the importance of transparent reporting and discussion of study findings according to their aims and with respect to their stage within the MPLC. Future research may benefit from using the MPLC framework for analyzing or determining the aims and design of patient preference studies.Keywords: patient preferences, medical product life cycle, preference research, benefit-harm assessment, patient-centered care, prostate cancer, systematic review

Published
2022

3. Visualizing anti-patterns in microservices at runtime:a systematic mapping study

Author

Parker, G. (Garrett), Kim, S. (Samuel), Maruf, A. A. (Abdullah Al), Cerny, T. (Tomas), Frajtak, K. (Karel), Tisnovsky, P. (Pavel), Taibi, D. (Davide), Parker, G. (Garrett), Kim, S. (Samuel), Maruf, A. A. (Abdullah Al), Cerny, T. (Tomas), Frajtak, K. (Karel), Tisnovsky, P. (Pavel), and Taibi, D. (Davide)

Abstract

In the world of microservices, companies must be able to create systems that operate in the most efficient way. To achieve this, anti-patterns must be avoided because of their detriment to the quality of the system. Some of the most troubling anti-patterns are hard to detect because of their appearance at runtime. Effectively removing anti-patterns from a system requires dynamic analysis because of the large size of microservice-based systems. While the detection of anti-patterns is helpful, being able to visualize them offers a great benefit to companies working with microservices. Seeing how the overall system is flowing and recognizing the existence of anti-patterns can help improve microservice-based systems. In this paper, a systematic mapping study was performed to find the current state of research on visualizing anti-patterns in microservices from the dynamic perspective. Several hundred papers were examined and a total of 31 were found to be relevant to the research topic. The papers, when analyzed, revealed that there are mechanisms to detect anti-patterns at runtime in microservices, and there are also mechanisms for visualizing the architecture of a microservice-based system. This study’s findings could help to identify and remove anti-patterns that occur during runtime in microservices, as well as a means of visualizing these anti-patterns.

Published
2023

4. Analyzing organizational structure of microservice projects based on contributor collaboration

Author

Li, X. (Xiaozhou), Abdelfattah, A. S. (Amr S.), Yero, J. (Jorge), d'Aragona, D. A. (Dario Amoroso), Cerny, T. (Tomas), Taibi, D. (Davide), Li, X. (Xiaozhou), Abdelfattah, A. S. (Amr S.), Yero, J. (Jorge), d'Aragona, D. A. (Dario Amoroso), Cerny, T. (Tomas), and Taibi, D. (Davide)

Abstract

Software system quality is strongly affected by the organizational structure and collaboration across developers. Effective and loosely coupled organization structures reflect the high quality of the system architecture and the efficiency with which this system can evolve. Especially for microservice-based systems, as the notion of “one-microservice-per-team” is highly recommended and advocated as one of the best practices in the industry, it is crucial for the companies to be aware of the status of their organizational structure and the critical contributors therein. To such an end, this paper proposes an approach to analyze the organizational structure of microservice-based software projects in terms of contributor collaboration and to identify the core contributors therein. Furthermore, we can also monitor the evolution of the project’s organizational structure via the growing collaboration activities through different releases. The proposed method shall help the companies and organizations adopting microservices better understand their organizational structure and make more effective decisions in maintaining the quality of microservice architectures.

Published
2023

5. Comparing 2D and augmented reality visualizations for microservice system understandability:a controlled experiment

Author

Abdelfattah, A. S. (Amr S.), Cerny, T. (Tomas), Taibi, D. (Davide), Vegas, S. (Sira), Abdelfattah, A. S. (Amr S.), Cerny, T. (Tomas), Taibi, D. (Davide), and Vegas, S. (Sira)

Abstract

Microservice-based systems are often complex to understand, especially when their sizes grow. Abstracted views help practitioners with the system understanding from a certain perspective. Recent advancement in interactive data visualization begs the question of whether established software engineering models to visualize system design remain the most suited approach for the service-oriented design of microservices. Our recent work proposed presenting a 3D visualization for microservices in augmented reality. This paper analyzes whether such an approach brings any benefits to practitioners when dealing with selected architectural questions related to system design quality. For this purpose, we conducted a controlled experiment involving 20 participants investigating their performance in identifying service dependency, service cardinality, and bottlenecks. Results show that the 3D enables novices to perform as well as experts in the detection of service dependencies, especially in large systems, while no differences are reported for the identification of service cardinality and bottlenecks. We recommend industry and researchers to further investigate AR for microservice architectural analysis, especially to ease the onboarding of new developers in microservice projects.

Published
2023

6. Benchmarks for end-to-end microservices testing

Author

Smith, S. (Sheldon), Robinson, E. (Ethan), Frederiksen, T. (Timmy), Stevens, T. (Trae), Cerny, T. (Tomas), Bures, M. (Miroslav), Taibi, D. (Davide), Smith, S. (Sheldon), Robinson, E. (Ethan), Frederiksen, T. (Timmy), Stevens, T. (Trae), Cerny, T. (Tomas), Bures, M. (Miroslav), and Taibi, D. (Davide)

Abstract

Testing microservice systems involves a large amount of planning and problem-solving. The difficulty of testing microservice systems increases as the size and structure of such systems become more complex. To help the microservice community and simplify experiments with testing and traffic simulation, we created a test benchmark containing full functional testing coverage for two well-established open-source microservice systems. Through our benchmark design, we aimed to demonstrate ways to overcome certain challenges and find effective strategies when testing microservices. In addition, to demonstrate our benchmark use, we conducted a case study to identify the best approaches to take to validate a full coverage of tests using service-dependency graph discovery and business process discovery using tracing.

Published
2023

7. Catalog and detection techniques of microservice anti-patterns and bad smells:a tertiary study

Author

Cerny, T. (Tomas), Abdelfattah, A. S. (Amr S.), Maruf, A. A. (Abdullah Al), Janes, A. (Andrea), Taibi, D. (Davide), Cerny, T. (Tomas), Abdelfattah, A. S. (Amr S.), Maruf, A. A. (Abdullah Al), Janes, A. (Andrea), and Taibi, D. (Davide)

Abstract

Background: Various works investigated microservice anti-patterns and bad smells in the past few years. We identified seven secondary publications that summarize these, but they have little overlap in purpose and often use different terms to describe the identified anti-patterns and smells. Objective: This work catalogs recurring bad design practices known as anti-patterns and bad smells for microservice architectures, and provides a classification into categories as well as methods for detecting these practices. Method: We conducted a systematic literature review in the form of a tertiary study targeting secondary studies identifying poor design practices for microservices. Results: We provide a comprehensive catalog of 58 disjoint anti-patterns, grouped into five categories, which we derived from 203 originally identified anti-patterns for microservices. Conclusion: The results provide a reference to microservice developers to design better-quality systems and researchers who aim to detect system quality based on anti-patterns. It also serves as an anti-pattern catalog for development-aiding tools, which are not currently available for microservice system development but could mitigate quality degradation throughout system evolution.

Published
2023

8. Niere

Author

Cerny, Thomas, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Kistler, Andreas D; https://orcid.org/0000-0002-4114-9560, Brandt, Simone; https://orcid.org/0000-0002-8558-6674, Gaspert, Ariana, Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Cerny, Thomas, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Kistler, Andreas D; https://orcid.org/0000-0002-4114-9560, Brandt, Simone; https://orcid.org/0000-0002-8558-6674, Gaspert, Ariana, and Cerny, Thomas; https://orcid.org/0000-0002-3404-7769

Abstract

Im Studium fällt es oft schwer, Themen wie die Glomerulonephritiden o. akute u. chronische TIN zu begreifen. Das liegt zT. daran, dass Nierenerkrankungen auf drei verschiedenen Ebenen eingeteilt werden können: Ätio-Pathogenese, anatomisch-histologische Veränderungen u. Klinik. Zwischen den Ebenen bestehen Korrelationen, aber oft kann eine Ätiologie (zB HepB, multiples Myelom) zu verschiedenen histologischen Mustern führen (=Schwierigkeit Nr. 1). Die anatomisch-histologische Sicht unterteilt Nierenerkrankungen weiter in vaskulär, glomerulär, tubulointerstitiell sowie zystisch bzw. neoplastisch; dabei kann eine Nierenerkrankung aber auch mehrere Strukturen betreffen (=Schwierigkeit Nr. 2). Schliesslich sind viele Diagnosen auf der anatomisch-histologischen Ebene definiert (zB membranöse GN, akute TIN), ohne per se eine Aussage über deren Ätiologie zu machen, gewisse Diagnosen hingegen auf der ätio-pathogenetischen (z.B. Lupusnephritis), ohne Nennung der dabei möglichen Muster. Dieses Wechselspiel zwischen Ätiologie, Histologie u. Klinik ist für die Glomerulonephritiden in 7 Abschn. 10.5 dargestellt.

Published
2023

9. Hals, Nase und Ohren

Author

Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Soyka, Michael; https://orcid.org/0000-0003-4179-4989, Ikenberg, Kristian, Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Soyka, Michael; https://orcid.org/0000-0003-4179-4989, and Ikenberg, Kristian

Abstract

Herausfordernd sind zum einen die HNO-Untersuchungsmethoden. Besonders die indirekte Laryngoskopie u. die Epipharyngoskopie können aufgrund eines Würgereizes schwierig sein u. bedürfen häufigen Übens u. grosser Erfahrung in der Interpretation der teils nur subtilen Veränderungen. Klinisch bereitet die Unterscheidung der verschiedenen Rhinitis-Formen u. deren Abgrenzung von der chronischen Rhinosinusitis immer wieder Mühe. Ähnlich schwierig ist es, ohne langjährige Erfahrung chronische Mittelohr- u. Gehörgangsprozesse wie Cholesteatome korrekt zu identifizieren. In der Mundhöhle u. dem Pharynx ist die Unterscheidung zwischen Entzündung u. Tumor auch für erfahrene Kliniker nicht immer eindeutig.

Published
2023

10. Allgemeine Pathologie

Author

Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Koelzer, Viktor H; https://orcid.org/0000-0001-9206-4885, Moch, Holger; https://orcid.org/0000-0002-7986-2839, Vogt, Peter K; https://orcid.org/0000-0002-4519-7500, Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Koelzer, Viktor H; https://orcid.org/0000-0001-9206-4885, Moch, Holger; https://orcid.org/0000-0002-7986-2839, and Vogt, Peter K; https://orcid.org/0000-0002-4519-7500

Abstract

Der menschliche Körper verfügt im Grunde genommen über ein limitiertes Repertoire, wie er auf Schädigungen reagieren kann. In diesem Kapitel finden Sie die Grundelemente dieser Antworten, geordnet nach den ätiologischen Hauptkategorien (vaskulär, infektiös, toxisch, autoimmun, metabolisch, neoplastisch etc.), welche durch das ganze Buch hindurch verwendet werden.

Published
2023

13. Weichteilsarkom

Author

Cerny, T., Issels, R. D., Budach, V., Schlag, P. M., Brecht, I., Schmoll, H. -J., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor

Published
2006
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18. A Nodalization Study of Phebus FPT-1 Experiment in MELCOR 2.2

Author

Cerny, T., Ptacek, M., Cerny, T., and Ptacek, M.

Abstract

Phebus, an integral experimental facility located in France, is scaled down version of a French 900 MWe pressurized water reactor (PWR) by a ratio of 1/5000. The goal of the facility is to study phenomena occurring during light water reactor severe accidents and validate models and computer codes used for calculation of sever accidents. The aim of this paper is to compare different modelling approaches in MELCOR 2.2 computer code and the influence on thermal hydraulic behavior and core degradation in comparison with experimental results.

Published
2022

19. Visualizing microservice architecture in the dynamic perspective:a systematic mapping study

Author

Gortney, M. E. (Mia E.), Harris, P. E. (Patrick E.), Cerny, T. (Tomas), Maruf, A. A. (Abdullah Al), Bures, M. (Miroslav), Taibi, D. (Davide), Tisnovsky, P. (Pavel), Gortney, M. E. (Mia E.), Harris, P. E. (Patrick E.), Cerny, T. (Tomas), Maruf, A. A. (Abdullah Al), Bures, M. (Miroslav), Taibi, D. (Davide), and Tisnovsky, P. (Pavel)

Abstract

As microservices become more popular, more drawbacks become apparent to developers. One issue that many teams face today is the failure to visualize the entire system architecture holistically. Without a full view of the system, the architecture can become convoluted as teams add and subtract from their system without reconciling their changes. One established practice to determine a view on the entire system involves dynamic analysis of microservice interaction and dependencies. In this mapping study, we investigate dynamic analysis as a way to visualize system architecture. Capturing the architectural view with dynamic analysis has the ability to build the system and then show its behavior at run-time. We identify dynamic analysis techniques, the corresponding tools, and the models that these practices can generate. The findings of this study are relevant to developers of decentralized systems looking for a way to visualize their system architecture in a dynamic perspective.

Published
2022

20. Architectural languages in the microservice era:a systematic mapping study

Author

Lelovic, L. (Luka), Mathews, M. (Michael), Elsayed, A. (Amr), Cerny, T. (Tomas), Frajtak, K. (Karel), Tisnovsky, P. (Pavel), Taibi, D. (Davide), Lelovic, L. (Luka), Mathews, M. (Michael), Elsayed, A. (Amr), Cerny, T. (Tomas), Frajtak, K. (Karel), Tisnovsky, P. (Pavel), and Taibi, D. (Davide)

Abstract

In modern software systems, Microservice Architecture (MSA) has gained popularity over monolithic design by providing the ability for flexible and independently upgradable services. Although there are considerable benefits that MSA provides, as new microservices are introduced into these MSA-based systems, they can become increasingly complex and hard to understand. Architectural languages are a potential solution to this problem because they can provide a comprehensive overview of system’s architecture as it changes. In this paper, the authors conduct a systematic mapping study to identify the architectural languages discussed in academia. In particular, the authors observe the architectural languages that have the capability of representing MSA-based systems. Through the use of a detailed query in 4 reliable indexers, a collection of 402 papers were filtered down to a small set of 19 relevant papers. This filtration was done based on a research paper inclusion criteria and a language inclusion criteria. With these papers, a total of 12 architectural languages were investigated for the representation of MSA-based systems.

Published
2022

22. Weichteilsarkom

Author

Cerny, T., Schmoll, H.-J., Schlag, P. M., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor

Published
1999
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24. Weichteilsarkome

Author

Cerny, T., Schmoll, H.-J., Hartlapp, J. H., Schlag, P. M., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor

Published
1997
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25. Supportivtherapie

Author

Casper, J., Aapro, M. S., Schmoll, H.-J., Link, H., Ludwig, H., Fritz, E., Bokemeyer, C., Sauer, H., Cerny, T., Schlag, R., Schöffski, P., Schöber, C., Hartenstein, R., Kleeberg, U. R., Heim, M. E., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor

Published
1996
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26. Toxizität

Author

Bokemeyer, C., Peters, H.-D., Schmoll, H.-J., Radermacher, J., Schöber, C., Kath, R., Niedermeyer, J., Fabel, H., Perry, M. C., Cerny, T., Weiß, J., Beck, J. D., Dörr, H. G., Meier, W., Bielack, S. S., Rossi, R., Gutjahr, P., Schneider, U., Buurmann, O., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor

Published
1996
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27. Antineoplastische Substanzen

Author

Osieka, R., Efferth, T., Borner, M., Cerny, T., Sauter, H., Barth, J., Schneemann, H., Paul, H., Sauer, H., Illiger, H.-J., Bornmann, L., Laupert, A., Illiger, H.-L., Berdel, W. E., Schmoll, H.-J., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor

Published
1996
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34. sPlotOpen:an environmentally balanced, open-access, global dataset of vegetation plots

Author

Sabatini, F. M. (Francesco Maria), Lenoir, J. (Jonathan), Hattab, T. (Tarek), Arnst, E. A. (Elise Aimee), Chytry, M. (Milan), Dengler, J. (Juergen), De Ruffray, P. (Patrice), Hennekens, S. M. (Stephan M.), Jandt, U. (Ute), Jansen, F. (Florian), Jimenez-Alfaro, B. (Borja), Kattge, J. (Jens), Levesley, A. (Aurora), Pillar, V. D. (Valerio D.), Purschke, O. (Oliver), Sandel, B. (Brody), Sultana, F. (Fahmida), Aavik, T. (Tsipe), Acic, S. (Svetlana), Acosta, A. T. (Alicia T. R.), Agrillo, E. (Emiliano), Alvarez, M. (Miguel), Apostolova, I. (Iva), Arfin Khan, M. A. (Mohammed A. S.), Arroyo, L. (Luzmila), Attorre, F. (Fabio), Aubin, I. (Isabelle), Banerjee, A. (Arindam), Bauters, M. (Marijn), Bergeron, Y. (Yves), Bergmeier, E. (Erwin), Biurrun, I. (Idoia), Bjorkman, A. D. (Anne D.), Bonari, G. (Gianmaria), Bondareva, V. (Viktoria), Brunet, J. (Jorg), Carni, A. (Andraz), Casella, L. (Laura), Cayuela, L. (Luis), Cerny, T. (Tomas), Chepinoga, V. (Victor), Csiky, J. (Janos), Custerevska, R. (Renata), De Bie, E. (Els), de Gasper, A. L. (Andre Luis), De Sanctis, M. (Michele), Dimopoulos, P. (Panayotis), Dolezal, J. (Jiri), Dziuba, T. (Tetiana), El-Sheikh, M. A. (Mohamed Abd El-Rouf Mousa), Enquist, B. (Brian), Ewald, J. (Joerg), Fazayeli, F. (Farideh), Field, R. (Richard), Finckh, M. (Manfred), Gachet, S. (Sophie), Galan-de-Mera, A. (Antonio), Garbolino, E. (Emmanuel), Gholizadeh, H. (Hamid), Giorgis, M. (Melisa), Golub, V. (Valentin), Alsos, I. G. (Inger Greve), Grytnes, J.-A. (John-Arvid), Guerin, G. R. (Gregory Richard), Gutierrez, A. G. (Alvaro G.), Haider, S. (Sylvia), Hatim, M. Z. (Mohamed Z.), Herault, B. (Bruno), Hinojos Mendoza, G. (Guillermo), Hoelzel, N. (Norbert), Homeier, J. (Juergen), Hubau, W. (Wannes), Indreica, A. (Adrian), Janssen, J. A. (John A. M.), Jedrzejek, B. (Birgit), Jentsch, A. (Anke), Juergens, N. (Norbert), Kacki, Z. (Zygmunt), Kapfer, J. (Jutta), Karger, D. N. (Dirk Nikolaus), Kavgaci, A. (Ali), Kearsley, E. (Elizabeth), Kessler, M. (Michael), Khanina, L. (Larisa), Killeen, T. (Timothy), Korolyuk, A. (Andrey), Kreft, H. (Holger), Kuehl, H. S. (Hjalmar S.), Kuzemko, A. (Anna), Landucci, F. (Flavia), Lengyel, A. (Attila), Lens, F. (Frederic), Lingner, D. V. (Debora Vanessa), Liu, H. (Hongyan), Lysenko, T. (Tatiana), Mahecha, M. D. (Miguel D.), Marceno, C. (Corrado), Martynenko, V. (Vasiliy), Moeslund, J. E. (Jesper Erenskjold), Monteagudo Mendoza, A. (Abel), Mucina, L. (Ladislav), Muller, J. V. (Jonas V.), Munzinger, J. (Jerome), Naqinezhad, A. (Alireza), Noroozi, J. (Jalil), Nowak, A. (Arkadiusz), Onyshchenko, V. (Viktor), Overbeck, G. E. (Gerhard E.), Partel, M. (Meelis), Pauchard, A. (Anibal), Peet, R. K. (Robert K.), Penuelas, J. (Josep), Perez-Haase, A. (Aaron), Peterka, T. (Tomas), Petrik, P. (Petr), Peyre, G. (Gwendolyn), Phillips, O. L. (Oliver L.), Prokhorov, V. (Vadim), Rasomavicius, V. (Valerijus), Revermann, R. (Rasmus), Rivas-Torres, G. (Gonzalo), Rodwell, J. S. (John S.), Ruprecht, E. (Eszter), Rusina, S. (Solvita), Samimi, C. (Cyrus), Schmidt, M. (Marco), Schrodt, F. (Franziska), Shan, H. (Hanhuai), Shirokikh, P. (Pavel), Sibik, J. (Jozef), Silc, U. (Urban), Sklenar, P. (Petr), Skvorc, Z. (Zeljko), Sparrow, B. (Ben), Sperandii, M. G. (Marta Gaia), Stancic, Z. (Zvjezdana), Svenning, J.-C. (Jens-Christian), Tang, Z. (Zhiyao), Tang, C. Q. (Cindy Q.), Tsiripidis, I. (Ioannis), Vanselow, K. A. (Kim Andre), Vasquez Martinez, R. (Rodolfo), Vassilev, K. (Kiril), Velez-Martin, E. (Eduardo), Venanzoni, R. (Roberto), Vibrans, A. C. (Alexander Christian), Violle, C. (Cyrille), Virtanen, R. (Risto), von Wehrden, H. (Henrik), Wagner, V. (Viktoria), Walker, D. A. (Donald A.), Waller, D. M. (Donald M.), Wang, H.-F. (Hua-Feng), Wesche, K. (Karsten), Whitfeld, T. J. (Timothy J. S.), Willner, W. (Wolfgang), Wiser, S. K. (Susan K.), Wohlgemuth, T. (Thomas), Yamalov, S. (Sergey), Zobel, M. (Martin), Bruelheide, H. (Helge), Sabatini, F. M. (Francesco Maria), Lenoir, J. (Jonathan), Hattab, T. (Tarek), Arnst, E. A. (Elise Aimee), Chytry, M. (Milan), Dengler, J. (Juergen), De Ruffray, P. (Patrice), Hennekens, S. M. (Stephan M.), Jandt, U. (Ute), Jansen, F. (Florian), Jimenez-Alfaro, B. (Borja), Kattge, J. (Jens), Levesley, A. (Aurora), Pillar, V. D. (Valerio D.), Purschke, O. (Oliver), Sandel, B. (Brody), Sultana, F. (Fahmida), Aavik, T. (Tsipe), Acic, S. (Svetlana), Acosta, A. T. (Alicia T. R.), Agrillo, E. (Emiliano), Alvarez, M. (Miguel), Apostolova, I. (Iva), Arfin Khan, M. A. (Mohammed A. S.), Arroyo, L. (Luzmila), Attorre, F. (Fabio), Aubin, I. (Isabelle), Banerjee, A. (Arindam), Bauters, M. (Marijn), Bergeron, Y. (Yves), Bergmeier, E. (Erwin), Biurrun, I. (Idoia), Bjorkman, A. D. (Anne D.), Bonari, G. (Gianmaria), Bondareva, V. (Viktoria), Brunet, J. (Jorg), Carni, A. (Andraz), Casella, L. (Laura), Cayuela, L. (Luis), Cerny, T. (Tomas), Chepinoga, V. (Victor), Csiky, J. (Janos), Custerevska, R. (Renata), De Bie, E. (Els), de Gasper, A. L. (Andre Luis), De Sanctis, M. (Michele), Dimopoulos, P. (Panayotis), Dolezal, J. (Jiri), Dziuba, T. (Tetiana), El-Sheikh, M. A. (Mohamed Abd El-Rouf Mousa), Enquist, B. (Brian), Ewald, J. (Joerg), Fazayeli, F. (Farideh), Field, R. (Richard), Finckh, M. (Manfred), Gachet, S. (Sophie), Galan-de-Mera, A. (Antonio), Garbolino, E. (Emmanuel), Gholizadeh, H. (Hamid), Giorgis, M. (Melisa), Golub, V. (Valentin), Alsos, I. G. (Inger Greve), Grytnes, J.-A. (John-Arvid), Guerin, G. R. (Gregory Richard), Gutierrez, A. G. (Alvaro G.), Haider, S. (Sylvia), Hatim, M. Z. (Mohamed Z.), Herault, B. (Bruno), Hinojos Mendoza, G. (Guillermo), Hoelzel, N. (Norbert), Homeier, J. (Juergen), Hubau, W. (Wannes), Indreica, A. (Adrian), Janssen, J. A. (John A. M.), Jedrzejek, B. (Birgit), Jentsch, A. (Anke), Juergens, N. (Norbert), Kacki, Z. (Zygmunt), Kapfer, J. (Jutta), Karger, D. N. (Dirk Nikolaus), Kavgaci, A. (Ali), Kearsley, E. (Elizabeth), Kessler, M. (Michael), Khanina, L. (Larisa), Killeen, T. (Timothy), Korolyuk, A. (Andrey), Kreft, H. (Holger), Kuehl, H. S. (Hjalmar S.), Kuzemko, A. (Anna), Landucci, F. (Flavia), Lengyel, A. (Attila), Lens, F. (Frederic), Lingner, D. V. (Debora Vanessa), Liu, H. (Hongyan), Lysenko, T. (Tatiana), Mahecha, M. D. (Miguel D.), Marceno, C. (Corrado), Martynenko, V. (Vasiliy), Moeslund, J. E. (Jesper Erenskjold), Monteagudo Mendoza, A. (Abel), Mucina, L. (Ladislav), Muller, J. V. (Jonas V.), Munzinger, J. (Jerome), Naqinezhad, A. (Alireza), Noroozi, J. (Jalil), Nowak, A. (Arkadiusz), Onyshchenko, V. (Viktor), Overbeck, G. E. (Gerhard E.), Partel, M. (Meelis), Pauchard, A. (Anibal), Peet, R. K. (Robert K.), Penuelas, J. (Josep), Perez-Haase, A. (Aaron), Peterka, T. (Tomas), Petrik, P. (Petr), Peyre, G. (Gwendolyn), Phillips, O. L. (Oliver L.), Prokhorov, V. (Vadim), Rasomavicius, V. (Valerijus), Revermann, R. (Rasmus), Rivas-Torres, G. (Gonzalo), Rodwell, J. S. (John S.), Ruprecht, E. (Eszter), Rusina, S. (Solvita), Samimi, C. (Cyrus), Schmidt, M. (Marco), Schrodt, F. (Franziska), Shan, H. (Hanhuai), Shirokikh, P. (Pavel), Sibik, J. (Jozef), Silc, U. (Urban), Sklenar, P. (Petr), Skvorc, Z. (Zeljko), Sparrow, B. (Ben), Sperandii, M. G. (Marta Gaia), Stancic, Z. (Zvjezdana), Svenning, J.-C. (Jens-Christian), Tang, Z. (Zhiyao), Tang, C. Q. (Cindy Q.), Tsiripidis, I. (Ioannis), Vanselow, K. A. (Kim Andre), Vasquez Martinez, R. (Rodolfo), Vassilev, K. (Kiril), Velez-Martin, E. (Eduardo), Venanzoni, R. (Roberto), Vibrans, A. C. (Alexander Christian), Violle, C. (Cyrille), Virtanen, R. (Risto), von Wehrden, H. (Henrik), Wagner, V. (Viktoria), Walker, D. A. (Donald A.), Waller, D. M. (Donald M.), Wang, H.-F. (Hua-Feng), Wesche, K. (Karsten), Whitfeld, T. J. (Timothy J. S.), Willner, W. (Wolfgang), Wiser, S. K. (Susan K.), Wohlgemuth, T. (Thomas), Yamalov, S. (Sergey), Zobel, M. (Martin), and Bruelheide, H. (Helge)

Abstract

Motivation: Assessing biodiversity status and trends in plant communities is critical for understanding, quantifying and predicting the effects of global change on ecosystems. Vegetation plots record the occurrence or abundance of all plant species co-occurring within delimited local areas. This allows species absences to be inferred, information seldom provided by existing global plant datasets. Although many vegetation plots have been recorded, most are not available to the global research community. A recent initiative, called ‘sPlot’, compiled the first global vegetation plot database, and continues to grow and curate it. The sPlot database, however, is extremely unbalanced spatially and environmentally, and is not open-access. Here, we address both these issues by (a) resampling the vegetation plots using several environmental variables as sampling strata and (b) securing permission from data holders of 105 local-to-regional datasets to openly release data. We thus present sPlotOpen, the largest open-access dataset of vegetation plots ever released. sPlotOpen can be used to explore global diversity at the plant community level, as ground truth data in remote sensing applications, or as a baseline for biodiversity monitoring. Main types of variable contained: Vegetation plots (n = 95,104) recording cover or abundance of naturally co-occurring vascular plant species within delimited areas. sPlotOpen contains three partially overlapping resampled datasets (c. 50,000 plots each), to be used as replicates in global analyses. Besides geographical location, date, plot size, biome, elevation, slope, aspect, vegetation type, naturalness, coverage of various vegetation layers, and source dataset, plot-level data also include community-weighted means and variances of 18 plant functional traits from the TRY Plant Trait Database. Spatial location and grain: Global, 0.01–40,000 m². Time period and grain: 1888–2015, recording dates. Major taxa and level of measuremen

Published
2021

41. Single agent rituximab in patients with follicular or mantle cell lymphoma: clinical and biological factors that are predictive of response and event-free survival as well as the effect of rituximab on the immune system: a study of the Swiss Group for Clinical Cancer Research (SAKK)

Author

Ghielmini, M., Rufibach, K., Salles, G., Leoncini-Franscini, L., Léger-Falandry, C., Cogliatti, S., Fey, M., Martinelli, G., Stahel, R., Lohri, A., Ketterer, N., Wernli, M., Cerny, T., and Schmitz, S.-F. Hsu

Published
2005
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48. sPlot:a new tool for global vegetation analyses

Author

Bruelheide, H. (Helge), Dengler, J. (Juergen), Jimenez-Alfaro, B. (Borja), Purschke, O. (Oliver), Hennekens, S. M. (Stephan M.), Chytry, M. (Milan), Pillar, V. D. (Valerio D.), Jansen, F. (Florian), Kattge, J. (Jens), Sandel, B. (Brody), Aubin, I. (Isabelle), Biurrun, I. (Idoia), Field, R. (Richard), Haider, S. (Sylvia), Jandt, U. (Ute), Lenoir, J. (Jonathan), Peet, R. K. (Robert K.), Peyre, G. (Gwendolyn), Sabatini, F. M. (Francesco Maria), Schmidt, M. (Marco), Schrodt, F. (Franziska), Winter, M. (Marten), Acic, S. (Svetlana), Agrillo, E. (Emiliano), Alvarez, M. (Miguel), Ambarli, D. (Didem), Angelini, P. (Pierangela), Apostolova, I. (Iva), Khan, M. A. (Mohammed A. S. Arfin), Arnst, E. (Elise), Attorre, F. (Fabio), Baraloto, C. (Christopher), Beckmann, M. (Michael), Berg, C. (Christian), Bergeron, Y. (Yves), Bergmeier, E. (Erwin), Bjorkman, A. D. (Anne D.), Bondareva, V. (Viktoria), Borchardt, P. (Peter), Botta-Dukat, Z. (Zoltan), Boyle, B. (Brad), Breen, A. (Amy), Brisse, H. (Henry), Byun, C. (Chaeho), Cabido, M. R. (Marcelo R.), Casella, L. (Laura), Cayuela, L. (Luis), Cerny, T. (Tomas), Chepinoga, V. (Victor), Csiky, J. (Janos), Curran, M. (Michael), Custerevska, R. (Renata), Stevanovic, Z. D. (Zora Dajic), De Bie, E. (Els), de Ruffray, P. (Patrice), De Sanctis, M. (Michele), Dimopoulos, P. (Panayotis), Dressler, S. (Stefan), Ejrnaes, R. (Rasmus), El-Sheikh, M. A. (Mohamed Abd El-Rouf Mousa), Enquist, B. (Brian), Ewald, J. (Joerg), Fagundez, J. (Jaime), Finckh, M. (Manfred), Font, X. (Xavier), Forey, E. (Estelle), Fotiadis, G. (Georgios), Garcia-Mijangos, I. (Itziar), de Gasper, A. L. (Andre Luis), Golub, V. (Valentin), Gutierrez, A. G. (Alvaro G.), Hatim, M. Z. (Mohamed Z.), He, T. (Tianhua), Higuchi, P. (Pedro), Holubova, D. (Dana), Hoelzel, N. (Norbert), Homeier, J. (Juergen), Indreica, A. (Adrian), Gursoy, D. I. (Deniz Isik), Jansen, S. (Steven), Janssen, J. (John), Jedrzejek, B. (Birgit), Jirousek, M. (Martin), Juergens, N. (Norbert), Kacki, Z. (Zygmunt), Kavgaci, A. (Ali), Kearsley, E. (Elizabeth), Kessler, M. (Michael), Knollova, I. (Ilona), Kolomiychuk, V. (Vitaliy), Korolyuk, A. (Andrey), Kozhevnikova, M. (Maria), Kozub, L. (Lukasz), Krstonosic, D. (Daniel), Kuehl, H. (Hjalmar), Kuehn, I. (Ingolf), Kuzemko, A. (Anna), Kuzmic, F. (Filip), Landucci, F. (Flavia), Lee, M. T. (Michael T.), Levesley, A. (Aurora), Li, C.-F. (Ching-Feng), Liu, H. (Hongyan), Lopez-Gonzalez, G. (Gabriela), Lysenko, T. (Tatiana), Macanovic, A. (Armin), Mahdavi, P. (Parastoo), Manning, P. (Peter), Marceno, C. (Corrado), Martynenko, V. (Vassiliy), Mencuccini, M. (Maurizio), Minden, V. (Vanessa), Moeslund, J. E. (Jesper Erenskjold), Moretti, M. (Marco), Mueller, J. V. (Jonas V.), Munzinger, J. (Jerome), Niinemets, U. (Ulo), Nobis, M. (Marcin), Noroozi, J. (Jalil), Nowak, A. (Arkadiusz), Onyshchenko, V. (Viktor), Overbeck, G. E. (Gerhard E.), Ozinga, W. A. (Wim A.), Pauchard, A. (Anibal), Pedashenko, H. (Hristo), Penuelas, J. (Josep), Perez-Haase, A. (Aaron), Peterka, T. (Tomas), Petrik, P. (Petr), Phillips, O. L. (Oliver L.), Prokhorov, V. (Vadim), Rasomavicius, V. (Valerijus), Revermann, R. (Rasmus), Rodwell, J. (John), Ruprecht, E. (Eszter), Rusina, S. (Solvita), Samimi, C. (Cyrus), Schaminee, J. H. (Joop H. J.), Schmiedel, U. (Ute), Sibik, J. (Jozef), Silc, U. (Urban), Skvorc, Z. (Zeljko), Smyth, A. (Anita), Sop, T. (Tenekwetche), Sopotlieva, D. (Desislava), Sparrow, B. (Ben), Stancic, Z. (Zvjezdana), Svenning, J.-C. (Jens-Christian), Swacha, G. (Grzegorz), Tang, Z. (Zhiyao), Tsiripidis, I. (Ioannis), Turtureanu, P. D. (Pavel Dan), Ugurlu, E. (Emin), Uogintas, D. (Domas), Valachovic, M. (Milan), Vanselow, K. A. (Kim Andre), Vashenyak, Y. (Yulia), Vassilev, K. (Kiril), Velez-Martin, E. (Eduardo), Venanzoni, R. (Roberto), Vibrans, A. C. (Alexander Christian), Violle, C. (Cyrille), Virtanen, R. (Risto), von Wehrden, H. (Henrik), Wagner, V. (Viktoria), Walker, D. A. (Donald A.), Wana, D. (Desalegn), Weiher, E. (Evan), Wesche, K. (Karsten), Whitfeld, T. (Timothy), Willner, W. (Wolfgang), Wiser, S. (Susan), Wohlgemuth, T. (Thomas), Yamalov, S. (Sergey), Zizka, G. (Georg), Zverev, A. (Andrei), Bruelheide, H. (Helge), Dengler, J. (Juergen), Jimenez-Alfaro, B. (Borja), Purschke, O. (Oliver), Hennekens, S. M. (Stephan M.), Chytry, M. (Milan), Pillar, V. D. (Valerio D.), Jansen, F. (Florian), Kattge, J. (Jens), Sandel, B. (Brody), Aubin, I. (Isabelle), Biurrun, I. (Idoia), Field, R. (Richard), Haider, S. (Sylvia), Jandt, U. (Ute), Lenoir, J. (Jonathan), Peet, R. K. (Robert K.), Peyre, G. (Gwendolyn), Sabatini, F. M. (Francesco Maria), Schmidt, M. (Marco), Schrodt, F. (Franziska), Winter, M. (Marten), Acic, S. (Svetlana), Agrillo, E. (Emiliano), Alvarez, M. (Miguel), Ambarli, D. (Didem), Angelini, P. (Pierangela), Apostolova, I. (Iva), Khan, M. A. (Mohammed A. S. Arfin), Arnst, E. (Elise), Attorre, F. (Fabio), Baraloto, C. (Christopher), Beckmann, M. (Michael), Berg, C. (Christian), Bergeron, Y. (Yves), Bergmeier, E. (Erwin), Bjorkman, A. D. (Anne D.), Bondareva, V. (Viktoria), Borchardt, P. (Peter), Botta-Dukat, Z. (Zoltan), Boyle, B. (Brad), Breen, A. (Amy), Brisse, H. (Henry), Byun, C. (Chaeho), Cabido, M. R. (Marcelo R.), Casella, L. (Laura), Cayuela, L. (Luis), Cerny, T. (Tomas), Chepinoga, V. (Victor), Csiky, J. (Janos), Curran, M. (Michael), Custerevska, R. (Renata), Stevanovic, Z. D. (Zora Dajic), De Bie, E. (Els), de Ruffray, P. (Patrice), De Sanctis, M. (Michele), Dimopoulos, P. (Panayotis), Dressler, S. (Stefan), Ejrnaes, R. (Rasmus), El-Sheikh, M. A. (Mohamed Abd El-Rouf Mousa), Enquist, B. (Brian), Ewald, J. (Joerg), Fagundez, J. (Jaime), Finckh, M. (Manfred), Font, X. (Xavier), Forey, E. (Estelle), Fotiadis, G. (Georgios), Garcia-Mijangos, I. (Itziar), de Gasper, A. L. (Andre Luis), Golub, V. (Valentin), Gutierrez, A. G. (Alvaro G.), Hatim, M. Z. (Mohamed Z.), He, T. (Tianhua), Higuchi, P. (Pedro), Holubova, D. (Dana), Hoelzel, N. (Norbert), Homeier, J. (Juergen), Indreica, A. (Adrian), Gursoy, D. I. (Deniz Isik), Jansen, S. (Steven), Janssen, J. (John), Jedrzejek, B. (Birgit), Jirousek, M. (Martin), Juergens, N. (Norbert), Kacki, Z. (Zygmunt), Kavgaci, A. (Ali), Kearsley, E. (Elizabeth), Kessler, M. (Michael), Knollova, I. (Ilona), Kolomiychuk, V. (Vitaliy), Korolyuk, A. (Andrey), Kozhevnikova, M. (Maria), Kozub, L. (Lukasz), Krstonosic, D. (Daniel), Kuehl, H. (Hjalmar), Kuehn, I. (Ingolf), Kuzemko, A. (Anna), Kuzmic, F. (Filip), Landucci, F. (Flavia), Lee, M. T. (Michael T.), Levesley, A. (Aurora), Li, C.-F. (Ching-Feng), Liu, H. (Hongyan), Lopez-Gonzalez, G. (Gabriela), Lysenko, T. (Tatiana), Macanovic, A. (Armin), Mahdavi, P. (Parastoo), Manning, P. (Peter), Marceno, C. (Corrado), Martynenko, V. (Vassiliy), Mencuccini, M. (Maurizio), Minden, V. (Vanessa), Moeslund, J. E. (Jesper Erenskjold), Moretti, M. (Marco), Mueller, J. V. (Jonas V.), Munzinger, J. (Jerome), Niinemets, U. (Ulo), Nobis, M. (Marcin), Noroozi, J. (Jalil), Nowak, A. (Arkadiusz), Onyshchenko, V. (Viktor), Overbeck, G. E. (Gerhard E.), Ozinga, W. A. (Wim A.), Pauchard, A. (Anibal), Pedashenko, H. (Hristo), Penuelas, J. (Josep), Perez-Haase, A. (Aaron), Peterka, T. (Tomas), Petrik, P. (Petr), Phillips, O. L. (Oliver L.), Prokhorov, V. (Vadim), Rasomavicius, V. (Valerijus), Revermann, R. (Rasmus), Rodwell, J. (John), Ruprecht, E. (Eszter), Rusina, S. (Solvita), Samimi, C. (Cyrus), Schaminee, J. H. (Joop H. J.), Schmiedel, U. (Ute), Sibik, J. (Jozef), Silc, U. (Urban), Skvorc, Z. (Zeljko), Smyth, A. (Anita), Sop, T. (Tenekwetche), Sopotlieva, D. (Desislava), Sparrow, B. (Ben), Stancic, Z. (Zvjezdana), Svenning, J.-C. (Jens-Christian), Swacha, G. (Grzegorz), Tang, Z. (Zhiyao), Tsiripidis, I. (Ioannis), Turtureanu, P. D. (Pavel Dan), Ugurlu, E. (Emin), Uogintas, D. (Domas), Valachovic, M. (Milan), Vanselow, K. A. (Kim Andre), Vashenyak, Y. (Yulia), Vassilev, K. (Kiril), Velez-Martin, E. (Eduardo), Venanzoni, R. (Roberto), Vibrans, A. C. (Alexander Christian), Violle, C. (Cyrille), Virtanen, R. (Risto), von Wehrden, H. (Henrik), Wagner, V. (Viktoria), Walker, D. A. (Donald A.), Wana, D. (Desalegn), Weiher, E. (Evan), Wesche, K. (Karsten), Whitfeld, T. (Timothy), Willner, W. (Wolfgang), Wiser, S. (Susan), Wohlgemuth, T. (Thomas), Yamalov, S. (Sergey), Zizka, G. (Georg), and Zverev, A. (Andrei)

Abstract

Aims: Vegetation‐plot records provide information on the presence and cover or abundance of plants co‐occurring in the same community. Vegetation‐plot data are spread across research groups, environmental agencies and biodiversity research centers and, thus, are rarely accessible at continental or global scales. Here we present the sPlot database, which collates vegetation plots worldwide to allow for the exploration of global patterns in taxonomic, functional and phylogenetic diversity at the plant community level. Results: sPlot version 2.1 contains records from 1,121,244 vegetation plots, which comprise 23,586,216 records of plant species and their relative cover or abundance in plots collected worldwide between 1885 and 2015. We complemented the information for each plot by retrieving climate and soil conditions and the biogeographic context (e.g., biomes) from external sources, and by calculating community‐weighted means and variances of traits using gap‐filled data from the global plant trait database TRY. Moreover, we created a phylogenetic tree for 50,167 out of the 54,519 species identified in the plots. We present the first maps of global patterns of community richness and community‐weighted means of key traits. Conclusions: The availability of vegetation plot data in sPlot offers new avenues for vegetation analysis at the global scale.

Published
2019

49. Hals, Nase und Ohren

Author

Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Soyka, Michael B; https://orcid.org/0000-0003-4179-4989, Ikenberg, Kristian, Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Soyka, Michael B; https://orcid.org/0000-0003-4179-4989, and Ikenberg, Kristian

Published
2019

50. Männliche Geschlechtsorgane und ableitende Harnwege

Author

Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Eberli, Daniel; https://orcid.org/0000-0001-8866-8010, Moch, Holger; https://orcid.org/0000-0002-7986-2839, Cerny, Thomas; https://orcid.org/0000-0002-3404-7769, Karlin, Kirill, Cerny, T ( Thomas ), Karlin, K ( Kirill ), Eberli, Daniel; https://orcid.org/0000-0001-8866-8010, and Moch, Holger; https://orcid.org/0000-0002-7986-2839

Published
2019

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