31 results on '"Cernigliaro JG"'
Search Results
2. Imaging techniques for diagnosing and managing Peyronie disease.
- Author
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Pradeep A, Alexander LF, Padilla-Maldonado GW, Taylor LI, Bowman AW, Broderick GA, and Cernigliaro JG
- Abstract
Erectile dysfunction (ED) affects up to 50% of men to some degree and has a variety of physiologic and psychologic causes, but many patients do not seek specialist treatment. One cause of ED is Peyronie disease (PD) defined by the presence of fibrotic plaques in the tunica albuginea which cause painful penile contractures. While diagnosing PD relies on clinical history and a focused history and physical exam, adding imaging studies can identify nonpalpable plaques and any underlying vasculogenic ED to tailor the extent of surgical treatment and determine when implantable penile prostheses are beneficial. After briefly reviewing penile anatomy, erectile function, and the clinical features of PD, this paper describes the imaging findings of vasculogenic ED on Doppler ultrasound (US), followed by the imaging appearance of PD on US, computed tomography (CT), and magnetic resonance imaging (MRI) to increase recognition of this disease and show how imaging can be used as a problem-solving tool for treatment planning and evaluating post-surgical complications, especially malfunctioning implanted devices. By increasing the understanding of how imaging can be used for patients with PD with or without vasculogenic ED before and after treatment, radiologists and urologists can collaborate on patient management., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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3. The telltale triangle sign.
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DiSantis DJ and Cernigliaro JG
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- 2022
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4. Acute anxiety and tachycardia in a hospitalized 59-year-old woman.
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Applewhite AI, Stancampiano FF, Harris DM, Bernet V, Cernigliaro JG, and Valery JR
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- Anxiety etiology, Female, Humans, Middle Aged, Hospitalization, Tachycardia diagnosis, Tachycardia etiology
- Published
- 2022
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5. In Vivo Comparison of Radiation Exposure in Third-Generation vs Second-Generation Dual-Source Dual-Energy CT for Imaging Urinary Calculi.
- Author
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Lam JP, Alexander LF, William HE, Hodge DO, Kofler JM, Morin RL, Thiel DD, and Cernigliaro JG
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- Humans, Radiation Dosage, Retrospective Studies, Tomography, X-Ray Computed, Radiation Exposure, Urinary Calculi diagnostic imaging
- Abstract
Purpose: To investigate the potential for decreasing radiation dose when utilizing a third-generation vs second-generation dual-source dual-energy CT (dsDECT) scanner, while maintaining diagnostic image quality and acceptable image noise. Materials and Methods : Retrospective analysis of patients who underwent dsDECT for clinical suspicion of urolithiasis from October 2, 2017, to September 5, 2018. Patient demographics, body mass index, abdominal diameter, scanning parameters, and CT dose index volume (CTDIvol) were recorded. Image quality was assessed by measuring the attenuation and standard deviation (SD) regions of interest in the aorta and in the bladder. Image noise was determined by averaging the SD at both levels. Patients were excluded if they had not undergone both third- and second-generation dual-energy CT (DECT), time between DECT was more than 2 years, or scan parameters were outside the standard protocol. Results: A total of 117 patients met the inclusion criteria. Examinations performed on a third-generation DECT had an average CTDIvol 12.3 mGy, while examinations performed on a second-generation DECT had an average CTDIvol 13.3 mGy ( p < 0.001). Average image noise was significantly lower for the third-generation DECT (SD = 10.3) compared with the second-generation DECT (SD = 13.9) ( p < 0.001). Conclusions: The third-generation dsDECT scanners can simultaneously decrease patient radiation dose and decrease image noise compared with second-generation DECT. These reductions in radiation exposure can be particularly important in patients with urinary stone disease who often require repeated imaging to evaluate for stone development and recurrence as well as treatment assessment.
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- 2021
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6. Perinephric myxoid pseudotumor of fat: A very rare entity that can mimic a renal cyst and retroperitoneal liposarcoma on imaging.
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Chen F, Desai MA, Cernigliaro JG, Edgar MA, and Alexander LF
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- Aged, 80 and over, Humans, Male, Cysts, Kidney Diseases, Cystic, Liposarcoma diagnostic imaging, Retroperitoneal Neoplasms
- Abstract
We present a case of perinephric myxoid pseudotumor of fat, a rare benign entity that often occurs in patients with non-neoplastic renal disease. In our case, an 80 year old man with end-stage renal disease was imaged over the course of 5 years during evaluation for renal transplantation. Imaging identified a left perinephric mass whose appearance over time and on different imaging modalities variably suggested a simple cyst, cystic neoplasm, and liposarcoma. Contrast enhanced examination was necessary to discern the solid nature of this mass, and ultimately, tissue sampling with histopathologic evaluation and molecular testing were required to make the diagnosis of myxoid pseudotumor of fat and exclude the imaging mimics., (Copyright © 2020 Elsevier Inc. All rights reserved.)
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- 2021
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7. Multimodality Imaging of Abdominopelvic Tumors with Venous Invasion.
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LeGout JD, Bailey RE, Bolan CW, Bowman AW, Chen F, Cernigliaro JG, and Alexander LF
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- Contrast Media, Diagnosis, Differential, Humans, Neoplasm Recurrence, Local diagnostic imaging, Prognosis, Abdominal Neoplasms diagnostic imaging, Abdominal Neoplasms pathology, Multimodal Imaging, Neoplasm Invasiveness diagnostic imaging, Vascular Neoplasms diagnostic imaging, Vascular Neoplasms secondary
- Abstract
A broad range of abdominal and pelvic tumors can manifest with or develop intraluminal venous invasion. Imaging features at cross-sectional modalities and contrast-enhanced US that allow differentiation of tumor extension within veins from bland thrombus include the expansile nature of tumor thrombus and attenuation and enhancement similar to those of the primary tumor. Venous invasion is a distinctive feature of hepatocellular carcinoma and renal cell carcinoma with known prognostic and treatment implications; however, this finding remains an underrecognized characteristic of multiple other malignancies-including cholangiocarcinoma, adrenocortical carcinoma, pancreatic neuroendocrine tumor, and primary venous leiomyosarcoma-and can be a feature of benign tumors such as renal angiomyolipoma and uterine leiomyomatosis. Recognition of tumor venous invasion at imaging has clinical significance and management implications for a range of abdominal and pelvic tumors. For example, portal vein invasion is a strong negative prognostic indicator in patients with hepatocellular carcinoma. In patients with rectal cancer, diagnosis of extramural venous invasion helps predict local and distant recurrence and is associated with worse survival. The authors present venous invasion by vascular distribution and organ of primary tumor origin with review of typical imaging features. Common pitfalls and mimics of neoplastic thrombus, including artifacts and anatomic variants, are described to help differentiate these findings from tumor in vein. By accurately diagnosing tumor venous invasion, especially in tumors where its presence may not be a typical feature, radiologists can help referring clinicians develop the best treatment strategies for their patients.
© RSNA, 2020.- Published
- 2020
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8. Absent, Abnormal, or Reduced Flow in the Testis: Thinking Beyond Torsion.
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Alexander LF, Caserta MP, Baden K, Livingston D, Cernigliaro JG, and Bhatt S
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- Humans, Male, Epididymitis diagnostic imaging, Spermatic Cord Torsion diagnostic imaging, Testis blood supply, Testis injuries, Ultrasonography, Doppler
- Published
- 2020
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9. Imaging Tips for Performing a Perfect Barium Swallow.
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DiSantis DJ, Lewis JI, Menias CO, Balfe DM, Morgan DE, and Cernigliaro JG
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- Humans, Barium Sulfate administration & dosage, Contrast Media administration & dosage, Esophageal Diseases diagnostic imaging
- Published
- 2019
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10. Multidetector CT Findings in the Abdomen and Pelvis after Damage Control Surgery for Acute Traumatic Injuries.
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Alexander LF, Hanna TN, LeGout JD, Roda MS, Cernigliaro JG, Mittal PK, and Harri PA
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- Abdominal Injuries surgery, Abdominal Wound Closure Techniques, Artifacts, Emergencies, Female, Foreign Bodies diagnostic imaging, Foreign Bodies surgery, Hemorrhage etiology, Hemorrhage therapy, Hemostatic Techniques instrumentation, Humans, Hypothermia etiology, Hypothermia therapy, Intra-Abdominal Hypertension diagnostic imaging, Laparotomy, Male, Pelvis injuries, Pelvis surgery, Resuscitation, Shock diagnostic imaging, Wounds, Gunshot diagnostic imaging, Wounds, Gunshot surgery, Wounds, Nonpenetrating diagnostic imaging, Wounds, Nonpenetrating surgery, Wounds, Penetrating diagnostic imaging, Wounds, Penetrating surgery, Abdominal Injuries diagnostic imaging, Multidetector Computed Tomography methods, Pelvis diagnostic imaging
- Abstract
After experiencing blunt or penetrating trauma, patients in unstable condition who are more likely to die of uncorrected shock than of incomplete injury repairs undergo emergency limited exploratory laparotomy, which is also known as damage control surgery (DCS). This surgery is part of a series of resuscitation steps, with the goal of stabilizing the patient's condition, with rapid surgical control of hemorrhage followed by supportive measures in the intensive care unit before definitive repair of injuries. These patients often are imaged with multidetector CT within 24-48 hours of the initial surgery. Knowledge of this treatment plan is critical to CT interpretation, because there are anatomic derangements and foreign bodies that would not be present in patients undergoing surgery for other reasons. Patients may have injuries beyond the surgical field that are only identified at imaging, which can alter the care plan. Abnormalities related to the resuscitation period such as the CT hypoperfusion complex and ongoing hemorrhage can be recognized at CT. Familiarity with these imaging and clinical findings is important, because they can be seen not only in trauma patients after DCS but also in other patients in the critical care setting. The interpretation of imaging studies can be helped by an understanding of the diagnostic challenges of grading organ injuries with surgical materials in place and the awareness of potential artifacts on images in these patients. Online supplemental material is available for this article.
© RSNA, 2019 See discussion on this article by LeBedis .- Published
- 2019
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11. Bilateral Sustained Nephrograms After Parenteral Administration of Iodinated Contrast Material: A Potential Biomarker for Acute Kidney Injury, Dialysis, and Mortality.
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McDonald JS, Steckler EM, McDonald RJ, Katzberg RW, Williamson EE, Cernigliaro JG, Hamadah AM, Gharaibeh K, Kallmes DF, and Leung N
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- Acute Kidney Injury mortality, Acute Kidney Injury therapy, Administration, Intravenous, Aged, Biomarkers, Creatinine, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Acute Kidney Injury diagnosis, Cardiac Catheterization, Contrast Media administration & dosage, Iohexol administration & dosage, Renal Dialysis, Tomography, X-Ray Computed
- Abstract
Objective: To determine whether persistent bilateral global nephrograms are associated with acute kidney injury (AKI), dialysis, and mortality., Patients and Methods: All patients who underwent (1) contrast-enhanced computed tomography (CT) or cardiac catheterization with iohexol between January 1, 2000, and December 31, 2014, and (2) noncontrast abdominal CT in the subsequent 24±6 hours were identified. Patients without preprocedure and postprocedure creatinine measurements or who received additional contrast material were excluded. Nephrograms were identified by radiologist review and CT attenuation measurements. Univariate and multivariate analyses were performed to determine nephrogram risk factors. Acute kidney injury (defined as a creatinine level of ≥0.5 mg/dL or Kidney Disease: Improving Global Outcomes stages 1-3), dialysis, and mortality proportions were compared between patients with and without bilateral global nephrograms using the Fisher's exact test., Results: A total of 123 patients met all inclusion criteria. The proportion of patients with a nephrogram was 37.4% (n=46), with a higher proportion following interventional (67% [18 of 30]) vs diagnostic (27.3% [9 of 33]) catheterization or contrast-enhanced computed tomography (31.7% [19 of 60]). Age (P=.002), chronic kidney disease (P=.05), and acute hypotension or shock (P=.02) were significant risk factors for nephrogram development. Patients with nephrogram had significantly higher rates of AKI (37.0% [17 of 46] vs 5.2% [4 of 77]; odds ratio [OR], 10.7 [95% CI, 3.31-34.5]; P<.001), dialysis (17.4% [8 of 46] vs 1.3% [1 of 77]; OR, 16.0 [95% CI, 1.93-133]; P=.001), and mortality (15.2% [7 of 46] vs 1.3% [1 of 77]; OR, 13.6 [1.62-115]; P=.003) than patients without nephrogram., Conclusion: The presence of persistent bilateral global nephrograms suggests an increased risk of AKI, dialysis, and mortality when compared with patients whose kidneys fully eliminated the contrast material., (Copyright © 2018 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
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12. Contrast-induced nephropathy in outpatients with preexisting renal impairment: a comparison between intravenous iohexol and iodixanol.
- Author
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Cernigliaro JG, Haley WE, Adolphson DP, Jepperson MA, Crook JE, Thomas CS, and Parker AS
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- Acute Kidney Injury diagnosis, Acute Kidney Injury epidemiology, Adult, Aged, Aged, 80 and over, Contrast Media administration & dosage, Contrast Media adverse effects, Dose-Response Relationship, Drug, Female, Florida epidemiology, Humans, Incidence, Injections, Intravenous, Iohexol administration & dosage, Male, Middle Aged, Prognosis, Renal Insufficiency complications, Renal Insufficiency epidemiology, Tomography, X-Ray Computed methods, Triiodobenzoic Acids administration & dosage, Acute Kidney Injury chemically induced, Iohexol adverse effects, Outpatients, Renal Insufficiency diagnosis, Tomography, X-Ray Computed adverse effects, Triiodobenzoic Acids adverse effects
- Abstract
Background: Concern for contrast-induced nephropathy (CIN) may result in administration of more costly agents. We prospectively compared outpatient CIN incidence of iodixanol to iohexol., Methods: Patients were randomized to receive 100ml of iohexol (n=47) or iodixanol (n=55). We compared patients who developed CIN using the Wilson score interval and also calculated an odds ratio for the development of CIN., Results: CIN rate for iohexol was 2% compared to 9% for iodixanol. Those receiving iodixanol were almost 5 times more likely to experience CIN., Conclusion: These results do not suggest a benefit of iodixanol over iohexol in the study population., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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13. The Capabilities and Limitations of Clinical Magnetic Resonance Imaging for Detecting Kidney Stones: A Retrospective Study.
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Ibrahim EH, Cernigliaro JG, Bridges MD, Pooley RA, and Haley WE
- Abstract
The purpose of this work was to investigate the performance of currently available magnetic resonance imaging (MRI) for detecting kidney stones, compared to computed tomography (CT) results, and to determine the characteristics of successfully detected stones. Patients who had undergone both abdominal/pelvic CT and MRI exams within 30 days were studied. The images were reviewed by two expert radiologists blinded to the patients' respective radiological diagnoses. The study consisted of four steps: (1) reviewing the MRI images and determining whether any kidney stone(s) are identified; (2) reviewing the corresponding CT images and confirming whether kidney stones are identified; (3) reviewing the MRI images a second time, armed with the information from the corresponding CT, noting whether any kidney stones are positively identified that were previously missed; (4) for all stones MRI-confirmed on previous steps, the radiologist experts being asked to answer whether in retrospect, with knowledge of size and location on corresponding CT, these stones would be affirmed as confidently identified on MRI or not. In this best-case scenario involving knowledge of stones and their locations on concurrent CT, radiologist experts detected 19% of kidney stones on MRI, with stone size being a major factor for stone identification., Competing Interests: The authors declare that they have no competing interests.
- Published
- 2016
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14. Detection of different kidney stone types: an ex vivo comparison of ultrashort echo time MRI to reference standard CT.
- Author
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Ibrahim el-SH, Cernigliaro JG, Pooley RA, Bridges MD, Giesbrandt JG, Williams JC, and Haley WE
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- Animals, Humans, Phantoms, Imaging, Reference Standards, Swine, Kidney Calculi diagnostic imaging, Kidney Calculi pathology, Magnetic Resonance Imaging methods, Tomography, X-Ray Computed methods
- Abstract
Background and Purpose: With the development of ultrashort echo time (UTE) sequences, it may now be possible to detect kidney stones by using magnetic resonance imaging (MRI). In this study, kidney stones of varying composition and sizes were imaged using both UTE MRI as well as the reference standard of computed tomography (CT), with different surrounding materials and scan setups., Methods: One hundred and fourteen kidney stones were inserted into agarose and urine phantoms and imaged both on a dual-energy CT (DECT) scanner using a standard renal stone imaging protocol and on an MRI scanner using the UTE sequence with both head and body surface coils. A subset of the stones representing all composition types and sizes was then inserted into the collecting system of porcine kidneys and imaged in vitro with both CT and MRI., Results: All of the stones were visible on both CT and MRI imaging. DECT was capable of differentiating between uric acid and nonuric acid stones. In MRI imaging, the choice of coil and large field of view (FOV) did not affect stone detection or image quality. The MRI images showed good visualization of the stones' shapes, and the stones' dimensions measured from MRI were in good agreement with the actual values (R(2)=0.886, 0.895, and 0.81 in the agarose phantom, urine phantom, and pig kidneys, respectively). The measured T2 relaxation times ranged from 4.2 to 7.5ms, but did not show significant differences among different stone composition types., Conclusions: UTE MRI compared favorably with the reference standard CT for imaging stones of different composition types and sizes using body surface coil and large FOV, which suggests potential usefulness of UTE MRI in imaging kidney stones in vivo., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2016
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15. Motion artifacts in kidney stone imaging using single-source and dual-source dual-energy CT scanners: a phantom study.
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Ibrahim el-SH, Cernigliaro JG, Pooley RA, Williams JC, and Haley WE
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- Humans, Motion, Phantoms, Imaging, Reproducibility of Results, Tomography Scanners, X-Ray Computed, Artifacts, Kidney Calculi diagnostic imaging, Tomography, X-Ray Computed instrumentation, Tomography, X-Ray Computed methods
- Abstract
Purpose: Dual-energy computed tomography (DECT) has shown the capability of differentiating uric acid (UA) from non-UA stones with 90-100% accuracy. With the invention of dual-source (DS) scanners, both low- and high-energy images are acquired simultaneously. However, DECT can also be performed by sequential acquisition of both images on single-source (SS) scanners. The objective of this study is to investigate the effects of motion artifacts on stone classification using both SS-DECT and DS-DECT., Methods: 114 kidney stones of different types and sizes were imaged on both DS-DECT and SS-DECT scanners with tube voltages of 80 and 140 kVp with and without induced motion. Postprocessing was conducted to create material-specific images from corresponding low- and high-energy images. The dual-energy ratio (DER) and stone material were determined and compared among different scans., Results: For the motionless scans, all stones were correctly classified with SS-DECT, while two cystine stones were misclassified with DS-DECT. When motion was induced, 94% of the stones were misclassified with SS-DECT versus 11% with DS-DECT (P < 0.0001). Stone size was not a factor in stone misclassification under motion. Stone type was not a factor in stone misclassification under motion with SS-DECT, although with DS-DECT, cystine showed higher number of stone misclassification., Conclusions: Motion artifacts could result in stone misclassification in DECT. This effect is more pronounced in SS-DECT versus DS-DECT, especially if stones of different types lie in close proximity to each other. Further, possible misinterpretation of the number of stones (i.e., missing one, or thinking that there are two) in DS-DECT could be a potentially significant problem.
- Published
- 2015
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16. How the ACR works: the vital role of the council steering committee: representing our members and setting college policy.
- Author
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Gunderman RB, Cernigliaro JG, Herrington WT, and Applegate KE
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- United States, Advisory Committees organization & administration, Committee Membership, Organizational Objectives, Radiology organization & administration, Societies, Medical organization & administration
- Published
- 2015
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17. How the ACR Works-The Chapters' Vital Role.
- Author
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Gunderman RB, Adams MJ, Cernigliaro JG, and Madison T
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- Humans, United States, Organizational Objectives, Radiology, Societies, Medical organization & administration
- Published
- 2015
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18. Forecasting the Effect of the Change in Timing of the ABR Diagnostic Radiology Examinations: Results of the ACR Survey of Practice Leaders.
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Bluth EI, Muroff LR, Cernigliaro JG, Moore AV Jr, Smith GG, Flug J, DeStigter KK, Allen B Jr, Thorwarth WT Jr, and Roberts AC
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- Certification trends, Personnel Staffing and Scheduling trends, Radiology trends, Surveys and Questionnaires, United States, Workforce, Certification statistics & numerical data, Forecasting, Leadership, Personnel Staffing and Scheduling statistics & numerical data, Radiology standards
- Abstract
The results of a survey sent to practice leaders in the ACR Practice of Radiology Environment Database show that the majority of responding groups will continue to hire recently trained residents and fellows even though they have been unable to take the final ABR diagnostic radiology certifying examination. However, a significant minority of private practice groups will not hire these individuals. The majority of private practices expect the timing change for the ABR certifying examinations to affect their groups' function. In contrast, the majority of academic medical school practices expect little or no impact. Residents and fellows should not expect work time off or protected time to study for the certifying examination or for their maintenance of certification examinations in the future., (Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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19. In vivo comparison of radiation exposure of dual-energy CT versus low-dose CT versus standard CT for imaging urinary calculi.
- Author
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Jepperson MA, Cernigliaro JG, Ibrahim el-SH, Morin RL, Haley WE, and Thiel DD
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- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, Nephrolithiasis diagnostic imaging, Radiation Dosage, Tomography, X-Ray Computed methods
- Abstract
Purpose: Dual-energy computed tomography (DECT) is an emerging imaging modality with the unique capability of determining urinary stone composition. This study compares radiation exposure of DECT, standard single-energy CT (SECT), and low-dose renal stone protocol single-energy CT (LDSECT) for the evaluation of nephrolithiasis in a single in vivo patient cohort., Materials and Methods: Following institutional review board (IRB) approval, we retrospectively reviewed 200 consecutive DECT examinations performed on patients with suspected urolithiasis over a 6-month period. Of these, 35 patients had undergone examination with our LDSECT protocol, and 30 patients had undergone examination of the abdomen and pelvis with our SECT imaging protocol within 2 years of the DECT examination. The CT dose index volume (CTDIvol) was used to compare radiation exposure between scans. Image quality was objectively evaluated by comparing image noise. Statistical evaluation was performed using a Student's t-test., Results: DECT performed at 80/140 kVp and 100/140 kVp did not produce a significant difference in radiation exposure compared with LDSECT (p=0.09 and 0.18, respectively). DECT performed at 80/140 kVp and 100/140 kVp produced an average 40% and 31%, respectively, reduction in radiation exposure compared with SECT (p<0.001). For patients imaged with the 100/140 kVp protocol, average values for images noise were higher in the LDSECT images compared with DECT images (p<0.001) and there was no significant difference in image noise between DECT and SECT images in the same patient (p=0.88). Patients imaged with the 80/140 kVp protocol had equivocal image noise compared with LDSECT images (p=0.44), however, DECT images had greater noise compared with SECT images in the same patient (p<0.001). Of the 75 patients included in the study, stone material was available for 16; DECT analysis correctly predicted stone composition in 15/16 patients (93%)., Conclusion: DECT provides knowledge of stone composition in addition to the anatomic information provided by LDSECT/SECT without increasing patient radiation exposure and with minimal impact on image noise.
- Published
- 2015
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20. The Clinical Impact of Accurate Cystine Calculi Characterization Using Dual-Energy Computed Tomography.
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Haley WE, Ibrahim el-SH, Qu M, Cernigliaro JG, Goldfarb DS, and McCollough CH
- Abstract
Dual-energy computed tomography (DECT) has recently been suggested as the imaging modality of choice for kidney stones due to its ability to provide information on stone composition. Standard postprocessing of the dual-energy images accurately identifies uric acid stones, but not other types. Cystine stones can be identified from DECT images when analyzed with advanced postprocessing. This case report describes clinical implications of accurate diagnosis of cystine stones using DECT.
- Published
- 2015
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21. Accuracy and efficiency of determining urinary calculi composition using dual-energy computed tomography compared with Hounsfield unit measurements for practicing physicians.
- Author
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Jepperson MA, Ibrahim el-SH, Taylor A, Cernigliaro JG, Haley WE, and Thiel DD
- Subjects
- Humans, Image Interpretation, Computer-Assisted, Image Processing, Computer-Assisted, Observer Variation, Physicians, Reproducibility of Results, Software, Time Factors, Urology standards, Tomography, X-Ray Computed methods, Urinary Calculi diagnosis, Urinary Calculi diagnostic imaging
- Abstract
Objective: To compare speed and accuracy for determining urinary calculi composition between dual-energy computed tomography (DECT) and Hounsfield unit (HU) measurements of calculi by a set of reviewers at varying levels of training and practice., Materials and Methods: Sixteen patients with known stone composition were randomly selected. Fourteen reviewers of varying levels of practice interpreted DECT and HU images from the selected patients to predict stone composition in 2 sessions (day 1: tutorial or flow sheet available for image interpretation and day 2: tutorial or flow sheet not available). Reviewers recorded HU values, stone color, and predicted stone composition as they were timed. Accuracy of image interpretation, determination of calculi composition, and interpretation time were compared., Results: DECT accuracy: image interpretation 100% (day 1) and 94% (day 2); predicted stone composition: 100% (day 1) and 73% (day 2). Mean interpretation time was the same for both days, 21 seconds per study (range, 11-40 seconds). HU accuracy: image interpretation 97% (day 1) and 91% (day 2); predicted stone composition was 45% accurate on both days. Mean interpretation time was 53 seconds per study (range, 28-79 seconds) and 41 seconds per study (range, 19-71 seconds) on days 1 and 2, respectively. Overall accuracy of determination of stone composition and interpretation time for DECT were essentially double those of the HU images (87% vs 45% and 21 vs 47 seconds, respectively). Reviewer's experience level did not affect accuracy or speed., Conclusion: DECT is easier to learn, faster to interpret, and more accurate than HU in determining urinary calculi composition for physicians at various levels of training and practice., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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22. Characterization of ureteral stents by dual-energy computed tomography: Clinical implications.
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Ibrahim el-SH, Haley WE, Jepperson MA, Wehle MJ, and Cernigliaro JG
- Abstract
Dual-energy computed-tomography (DECT) has been suggested as the method of choice for imaging urinary calculi due to the modality's high sensitivity for detecting stones and its capability of accurately differentiating between uric-acid (UA) and non-UA (predominantly calcium) stones. The clinical significance of the latter feature relates to the differences in management of UA vs non-UA calculi. Like calculi, ureteral stents are assigned color by the dual-energy post-processing algorithm, which may lead to improved or worsened stone visualization based on the resulting stent/stone contrast. Herein we depict the case of a nephrolithiasis patient with bilateral stents, each with different color, clearly displaying the effect of stent color on stone visualization. Further, three-dimensional reconstruction of the DECT images illustrates advantages of this enhancement compared to conventional two-dimensional computed tomography. The resulting stent/stone contrast produces an unanticipated potential advantage of DECT in patients with urolithiasis and stents and may promote improved management decision-making.
- Published
- 2014
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23. Case series demonstrating the clinical utility of dual energy computed tomography in patients requiring stents for urinary calculi.
- Author
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Jepperson MA, Thiel DD, Cernigliaro JG, Broderick GA, and Haley WE
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- Aged, Female, Humans, Kidney Calculi chemistry, Kidney Calculi therapy, Male, Middle Aged, Ureteral Calculi chemistry, Ureteral Calculi therapy, Uric Acid analysis, Kidney Calculi diagnostic imaging, Stents, Tomography, X-Ray Computed methods, Ureteral Calculi diagnostic imaging
- Abstract
Dual energy computed tomography (DECT) utilizes the material change in attenuation when imaged at two different energies to determine the composition of urinary calculi as uric acid or non-uric acid. We discuss a series of case reports illustrating DECT's ability to provide immediate determination of uric acid versus non-uric acid calculi and facilitate more informed clinical decision-making. Further, these cases demonstrate a unique population of patients with ureteral stents and percutaneous nephrostomy tubes that benefit from DECT's ability to create a virtual color contrast between an indwelling device and the stone material and thereby significantly impacting patient morbidity.
- Published
- 2014
24. Kidney stone imaging with 3D ultra-short echo time (UTE) magnetic resonance imaging. A phantom study.
- Author
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Ibrahim el-SH, Pooley RA, Bridges MD, Cernigliaro JG, and Haley WE
- Subjects
- Humans, Imaging, Three-Dimensional, Kidney Calculi diagnostic imaging, Kidney Calculi urine, Sepharose, Time Factors, Tomography, X-Ray Computed, Kidney Calculi diagnosis, Magnetic Resonance Imaging methods, Phantoms, Imaging
- Abstract
Computed tomography (CT) is the current gold standard for imaging kidney stones, albeit at the cost of radiation exposure. Conventional magnetic resonance imaging (MRI) sequences are insensitive to detecting the stones because of their appearance as a signal void. With the development of 2D ultra-short echo-time (UTE) MRI sequences, it becomes possible to image kidney stones in vitro. In this work, we optimize and implement a modified 3D UTE MRI sequence for imaging kidney stones embedded in agarose phantoms mimicking the kidney tissue and in urine phantoms at 3.0T. The proposed technique is capable of imaging the stones with high spatial resolution in a short scan time.
- Published
- 2014
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25. Dual-energy CT for the evaluation of urinary calculi: image interpretation, pitfalls and stone mimics.
- Author
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Jepperson MA, Cernigliaro JG, Sella D, Ibrahim E, Thiel DD, Leng S, and Haley WE
- Subjects
- Humans, Nephrostomy, Percutaneous adverse effects, Radiography, Dual-Energy Scanned Projection instrumentation, Radiography, Dual-Energy Scanned Projection methods, Tomography, X-Ray Computed instrumentation, Tomography, X-Ray Computed methods, Urinary Calculi diagnostic imaging
- Abstract
Urolithiasis is a common disease with a reported prevalence between 4% and 20% in developed countries. Determination of urinary calculi composition is a key factor in preoperative evaluation, treatment, and stone recurrence prevention. Prior to the introduction of dual-energy computed tomography (DECT), available methods for determining urinary stone composition were only available after stone extraction, and thereby unable to aid in optimized stone management prior to intervention. DECT utilizes the attenuation difference produced by two different x-ray energy spectra to quantify urinary calculi composition as uric acid or non-uric acid (with likely further classification in the future) while still providing the information attained with a conventional CT. Knowledge of DECT imaging pitfalls and stone mimics is important, as the added benefit of dual-energy analysis is the determination of stone composition, which in turn affects all aspects of stone management. This review briefly describes DECT principles, scanner types and acquisition protocols for the evaluation of urinary calculi as they relate to imaging pitfalls (inconsistent characterization of small stones, small dual-energy field of view, and mischaracterization from surrounding material) and stone mimics (drainage devices) that may adversely impact clinical decisions. We utilize our clinical experience from scanning over 1200 patients with this new imaging technique to present clinically relevant examples of imaging pitfalls and possible mechanisms for resolution., (Copyright © 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
26. Noncathartic CT colonography: Image quality assessment and performance and in a screening cohort.
- Author
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Fletcher JG, Silva AC, Fidler JL, Cernigliaro JG, Manduca A, Limburg PJ, Wilson LA, Engelby TA, Spencer G, Harmsen WS, Mandrekar J, and Johnson CD
- Subjects
- Adult, Aged, Cathartics, Cohort Studies, Contrast Media, Enema, Female, Humans, Image Enhancement methods, Male, Middle Aged, Prevalence, Reproducibility of Results, Risk Assessment, Sensitivity and Specificity, United States epidemiology, Barium Sulfate, Colonic Polyps diagnostic imaging, Colonic Polyps epidemiology, Colonography, Computed Tomographic statistics & numerical data, Image Interpretation, Computer-Assisted methods, Mass Screening statistics & numerical data
- Abstract
Objective: Cathartic bowel preparation is a major barrier for colorectal cancer screening. We examined noncathartic CT colonography (CTC) quality and performance using four similar bowel-tagging regimens in an asymptomatic screening cohort., Subjects and Methods: This prospective study included 564 asymptomatic subjects who underwent noncathartic CTC without dietary modification but with 21 g of barium with or without iodinated oral contrast material (four regimens). The quality of tagging with oral agents was evaluated. A gastrointestinal radiologist evaluated examinations using primary 2D search supplemented by electronic cleansing (EC) and 3D problem solving. Results were compared with complete colonoscopy findings after bowel purgation and with retrospective unblinded evaluation in 556 of the 564 (99%) subjects., Results: Of the 556 subjects, 7% (37/556) and 3% (16/556) of patients had 52 and 20 adenomatous polyps ≥ 6 and ≥ 10 mm, respectively. The addition of iodine significantly improved the percentage of labeled stool (p ≤ 0.0002) and specificity (80% vs 89-93%, respectively; p = 0.046). The overall sensitivity of noncathartic CTC for adenomatous polyps ≥ 6 mm was 76% (28/37; 95% CI, 59-88%), which is similar to the sensitivity of the iodinated regimens with most patients (sensitivity: 231 patients, 74% [14/19; 95% CI, 49-91%]; 229 patients, 80% [12/15; 95% CI, 52-96%]). The negative predictive value was 98% (481/490), and the lone cancer was detected (0.2%, 1/556). EC was thought to improve conspicuity of 10 of 21 visible polyps ≥ 10 mm., Conclusion: In this prospective study of asymptomatic subjects, the per-patient sensitivity of noncathartic CTC for detecting adenomas ≥ 6 mm was approximately 76%. Inclusion of oral iodine contrast material improves examination specificity and the percentage of labeled stool. EC may improve polyp conspicuity.
- Published
- 2013
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27. Three-dimensional dual-energy computed tomography for enhancing stone/stent contrasting and stone visualization in urolithiasis.
- Author
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Ibrahim el-SH, Haley WE, Jepperson MA, Thiel DD, Wehle MJ, and Cernigliaro JG
- Abstract
The use of dual-energy computed tomography (DECT) for evaluating urinary calculi has been appreciated due to the modality's capability of differentiating between uric acid (UA) and non-UA stones, which are color coded based on a postprocessing algorithm. No other imaging modality or laboratory test is able to identify the stone composition without first attaining the stone material. Knowledge of the stone composition is clinically significant since UA calculi may be treated medically whereas non-UA calculi may require surgical removal. Regardless of the stone type, ureteral stents are often placed to prevent or treat obstruction. Recent work has demonstrated that commonly used stents are also colored based on their dual energy characteristics and may thereby either improve or obscure the identification of adjacent calculi. Herein, we report the case of a 65-year-old man who underwent percutaneous nephrolithotomy of a large staghorn stone with subsequent significant residual stone fragments noted on a follow-up scan. By using three-dimensional DECT and taking advantage of color contrasting, the stone composition, burden, shape, and boundary were clearly depicted apart from the adjacent stent, resulting in successful medical treatment and obviating the need for further surgical intervention.
- Published
- 2013
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- View/download PDF
28. Determination of ureter stent appearance on dual-energy computed tomography scan.
- Author
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Jepperson MA, Thiel DD, Cernigliaro JG, Broderick GA, Parker AS, and Haley WE
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Kidney Calculi surgery, Male, Middle Aged, Phantoms, Imaging, Ureter diagnostic imaging, Kidney Calculi diagnostic imaging, Stents, Tomography, X-Ray Computed methods, Ureter surgery, Urologic Surgical Procedures methods
- Abstract
Objective: To examine the dual-energy computed tomography (DECT) properties of 7 commonly used ureteral stents to optimize stent selection for calculi monitored using DECT. The use of DECT to evaluate renal and ureteral calculi has recently increased., Methods: Seven stents were individually placed in a fish bowl phantom and imaged using a Siemens Somatom Definition Flash CT scanner. DECT peak tube potentials of 80 and 140 kVp and 100 and 140 kVp were used, reflecting our current dual-energy protocols. These were compared to 31 in vivo stents of known composition. The data were reconstructed on a multimodality WorkPlace (Siemens) using CT syngo Post-Processing Suite software., Results: The average patient age was 64 years (range 27-90). The average body mass index was 31.9 kg/m(2) (range 24-51.6). Of the 27 patients, 4 had uric acid stones and 22 had calcium-based stones; 1 patient had undergone renal transplantation. No difference was seen in the dual-energy characterization of stents from the same manufacturer. All imaged Cook and Bard stents had a dual-energy characterization that approached that of calcium stones (blue). All Boston Scientific and Gyrus ACMI stents had a dual-energy characterization resembling that of uric acid stones (red)., Conclusion: The present study evaluated the stent appearance on DECT for various stent manufacturers. This information will aid in the optimal stent selection for patients undergoing treatment of renal calculi and followed up with DECT., (Copyright © 2012 Elsevier Inc. All rights reserved.)
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- 2012
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29. High-dose gadodiamide for catheter angiography and CT in patients with varying degrees of renal insufficiency: Prevalence of subsequent nephrogenic systemic fibrosis and decline in renal function.
- Author
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Bridges MD, St Amant BS, McNeil RB, Cernigliaro JG, Dwyer JP, and Fitzpatrick PM
- Subjects
- Adult, Aged, Aged, 80 and over, Catheterization statistics & numerical data, Comorbidity, Contrast Media, Female, Florida epidemiology, Humans, Male, Middle Aged, Prevalence, Risk Assessment methods, Risk Factors, Young Adult, Gadolinium DTPA, Nephrogenic Fibrosing Dermopathy diagnostic imaging, Nephrogenic Fibrosing Dermopathy epidemiology, Renal Insufficiency diagnosis, Renal Insufficiency epidemiology, Tomography, X-Ray Computed statistics & numerical data
- Abstract
Objective: The purpose of our study was to evaluate the prevalence of nephrogenic systemic fibrosis (NSF) and nephrotoxicity among patients with differing degrees of renal dysfunction who are exposed to high doses of gadodiamide., Materials and Methods: A search of medical records identified patients who received high-dose IV gadodiamide for catheter angiography or CT between January 2002 and December 2005. The cohort was limited to patients who had received a dose of at least 40 mL of gadodiamide during a single imaging session, who underwent at least 1 year of clinical follow-up, and who had moderate to end-stage renal disease (estimated glomerular filtration rate [GFR] < 60 mL/min/1.73 m(2)) established within the previous 48 hours. Any observation suggestive of NSF was recorded, as were all estimated GFR values obtained during the 2 weeks before and the 5 days after gadodiamide administration., Results: Sixty-one patients met the inclusion criteria. The median estimated GFR was 30 mL/min/1.73 m(2) (range, 3-57 mL/min/1.73 m(2)). The median gadodiamide exposure was 80 mL (range, 40-200 mL). NSF eventually developed in one of the 61 patients, yielding a prevalence of 1.6%. Among the 33 patients not undergoing dialysis with estimated GFR documented within 5 days after contrast injection, the change in estimated GFR ranged from -8.8 to 42.9 mL/min/1.73 m(2), with a statistically significant median improvement of 2.4 mL/min/1.73 m(2) (p = 0.007)., Conclusion: Although gadolinium exposure appears to be a necessary precondition for NSF, gadolinium-based contrast agents alone are not sufficient to cause the disorder, even in very high doses. Clinically relevant nephrotoxicity of gadolinium-based contrast agents was not found.
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- 2009
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30. Esophageal Intramural Pseudodiverticulosis.
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DeVault KR and Cernigliaro JG
- Abstract
Esophageal intramural pseudodiverticulosis (EIPD) is an uncommon esophageal abnormality that is best diagnosed with a barium esophagram. The disorder is usually associated with other esophageal pathology, including strictures, motility disturbances, and other conditions that are outlined later. There is no specific treatment (either surgical or medical) for EIPD itself, and treatment should be directed at the underlying, associated conditions. If this condition is diagnosed on a barium study, endoscopy usually is needed to treat an associated stricture or to diagnose an associated inflammatory condition (particularly acid reflux and esophageal infections). Thus, endoscopy and barium studies are critical to guide the management of this condition.
- Published
- 2003
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31. Iliopsoas compartment: normal anatomy and pathologic processes.
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Torres GM, Cernigliaro JG, Abbitt PL, Mergo PJ, Hellein VF, Fernandez S, and Ros PR
- Subjects
- Abscess diagnostic imaging, Hemorrhage diagnostic imaging, Humans, Muscle Neoplasms diagnostic imaging, Muscle, Skeletal anatomy & histology, Psoas Muscles anatomy & histology, Radiography, Muscle, Skeletal diagnostic imaging, Muscular Diseases diagnostic imaging, Psoas Muscles diagnostic imaging
- Abstract
The iliopsoas compartment is an extraperitoneal space that contains the greater psoas, smaller psoas, and iliac muscles. Many pathologic processes may involve the iliopsoas compartment, including inflammatory, hemorrhagic, and neoplastic conditions. Psoas muscle infection is usually due to direct extension from contiguous structures. With the decreasing incidence of tuberculosis, the majority of psoas abscesses now encountered have a pyogenic origin. Hemorrhage into the psoas muscle can be spontaneous or secondary to various conditions. Neoplastic involvement of the psoas muscle is usually due to contiguous spread and is rarely primary. With the refinement of imaging modalities, there has been increased recognition of diseases that involve the iliopsoas compartment. Although these conditions may look similar radiologically, they can be correctly diagnosed by combining the radiologic findings with the clinical history. Biopsy is effective in diagnosis of such conditions; aspiration and drainage are effective in both diagnosis and therapy.
- Published
- 1995
- Full Text
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