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30 results on '"Cerni, Felipe Augusto"'

4. The State-of-the-Art of the Humoral Memory Response to Snakebites: Insights from the Yanomami Population

Author

Jati, Sewbert Rodrigues, primary, dos Anjos Martins, Thais Andréa, additional, Rocha, Anderson Maciel, additional, Melo-dos-Santos, Guilherme, additional, de Oliveira, Isadora Sousa, additional, Ferreira, Isabela Gobbo, additional, de Farias, Altair Seabra, additional, Filardi, Eloise T. M., additional, Cerni, Felipe Augusto, additional, Sartim, Marco Aurélio, additional, de Almeida Gonçalves Sachett, Jacqueline, additional, Monteiro, Wuelton Marcelo, additional, and Pucca, Manuela Berto, additional

Published
2023
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5. Statement of Peer Review—Immersing in a Neglected Problem Inside the Amazon Jungle: Abstracts of the 1st International Symposium on Research in Venomous Animals, Manaus, Brazil

Author

Sachett, Jacqueline, primary, Murta, Felipe, additional, da Silva, Ana Maria Moura, additional, de Farias, Altair Seabra, additional, Kaefer, Igor Luis, additional, Bisneto, Pedro, additional, Cerni, Felipe Augusto, additional, Carvalho, Érica da Silva, additional, Rocha, Gisele Santos, additional, Koolen, Hector, additional, Machado, Vinícius Azevedo, additional, Costa, Allyson Guimarães, additional, Sampaio, Vanderson, additional, Pucca, Manuela, additional, Wen, Fan Hui, additional, Sartim, Marco Aurélio, additional, and Monteiro, Wuelton, additional

Published
2023
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7. Minor snake venom proteins: Structure, function and potential applications

Author

Boldrini-França, Johara, Cologna, Camila Takeno, Pucca, Manuela Berto, Bordon, Karla de Castro Figueiredo, Amorim, Fernanda Gobbi, Anjolette, Fernando Antonio Pino, Cordeiro, Francielle Almeida, Wiezel, Gisele Adriano, Cerni, Felipe Augusto, Pinheiro-Junior, Ernesto Lopes, Shibao, Priscila Yumi Tanaka, Ferreira, Isabela Gobbo, de Oliveira, Isadora Sousa, Cardoso, Iara Aimê, and Arantes, Eliane Candiani

Published
2017
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9. The State-of-the-Art of the Humoral Memory Response to Snakebites: Insights from the Yanomami Population

Author

Jati, Sewbert Rodrigues, dos Anjos Martins, Thais Andréa, Rocha, Anderson Maciel, Melo-dos-Santos, Guilherme, de Oliveira, Isadora Sousa, Ferreira, Isabela Gobbo, de Farias, Altair Seabra, Filardi, Eloise T. M., Cerni, Felipe Augusto, Sartim, Marco Aurélio, Sachett, Jacqueline de Almeida Gonçalves, Monteiro, Wuelton Marcelo, Pucca, Manuela Berto, Jati, Sewbert Rodrigues, dos Anjos Martins, Thais Andréa, Rocha, Anderson Maciel, Melo-dos-Santos, Guilherme, de Oliveira, Isadora Sousa, Ferreira, Isabela Gobbo, de Farias, Altair Seabra, Filardi, Eloise T. M., Cerni, Felipe Augusto, Sartim, Marco Aurélio, Sachett, Jacqueline de Almeida Gonçalves, Monteiro, Wuelton Marcelo, and Pucca, Manuela Berto

Abstract

Snakebite envenomation (SBE)-induced immunity refers to individuals who have been previously bitten by a snake and developed a protective immune response against subsequent envenomations. The notion stems from observations of individuals, including in the indigenous population, who present only mild signs and symptoms after surviving multiple SBEs. Indeed, these observations have engendered scientific interest and prompted inquiries into the potential development of a protective immunity from exposure to snake toxins. This review explores the evidence of a protective immune response developing following SBE. Studies suggest that natural exposure to snake toxins can trigger protection from the severity of SBEs, mediated by specific antibodies. However, the evaluation of the immune memory response in SBE patients remains challenging. Further research is needed to elucidate the immune response dynamics and identify potential targets for therapeutic interventions. Furthermore, the estimation of the effect of previous exposures on SBE epidemiology in hyperendemic areas, such as in the indigenous villages of the Amazon region (e.g., the Yanomami population) is a matter of debate.

Published
2023

11. Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for proline-free ACE-inhibitors

Author

Pucca, Manuela Berto, Cerni, Felipe Augusto, Pinheiro-Junior, Ernesto Lopes, Zoccal, Karina Furlani, Bordon, Karla de Castro Figueiredo, Amorim, Fernanda Gobbi, Peigneur, Steve, Vriens, Kim, Thevissen, Karin, Cammue, Bruno Philippe Angelo, Júnior, Ronaldo Bragança Martins, Arruda, Eurico, Faccioli, Lúcia Helena, Tytgat, Jan, and Arantes, Eliane Candiani

Published
2016
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13. Tityus serrulatus venom – A lethal cocktail

Author

Pucca, Manuela Berto, Cerni, Felipe Augusto, Pinheiro Junior, Ernesto Lopes, Bordon, Karla de Castro Figueiredo, Amorim, Fernanda Gobbi, Cordeiro, Francielle Almeida, Longhim, Heloisa Tavoni, Cremonez, Caroline Marroni, Oliveira, Guilherme Honda, and Arantes, Eliane Candiani

Published
2015
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16. Anti-vaccination movements in the world and in Brazil

Author

Oliveira, Isadora Sousa de, primary, Cardoso, Larissa Soares, additional, Ferreira, Isabela Gobbo, additional, Alexandre-Silva, Gabriel Melo, additional, Jacob, Beatriz de Cássia da Silva, additional, Cerni, Felipe Augusto, additional, Monteiro, Wuelton Marcelo, additional, Zottich, Umberto, additional, and Pucca, Manuela Berto, additional

Published
2022
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17. Bothrops bilineatus: An Arboreal Pitviper in the Amazon and Atlantic Forest

Author

Bernarde, Paulo Sérgio, primary, Pucca, Manuela Berto, additional, Mota-da-Silva, Ageane, additional, da Fonseca, Wirven Lima, additional, de Almeida, Marllus Rafael Negreiros, additional, de Oliveira, Isadora Sousa, additional, Cerni, Felipe Augusto, additional, Gobbi Grazziotin, Felipe, additional, Sartim, Marco A., additional, Sachett, Jacqueline, additional, Wen, Fan Hui, additional, Moura-da-Silva, Ana Maria, additional, and Monteiro, Wuelton M., additional

Published
2021
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19. From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery

Author

Bordon, Karla de Castro Figueiredo, primary, Cologna, Camila Takeno, additional, Fornari-Baldo, Elisa Corrêa, additional, Pinheiro-Júnior, Ernesto Lopes, additional, Cerni, Felipe Augusto, additional, Amorim, Fernanda Gobbi, additional, Anjolette, Fernando Antonio Pino, additional, Cordeiro, Francielle Almeida, additional, Wiezel, Gisele Adriano, additional, Cardoso, Iara Aimê, additional, Ferreira, Isabela Gobbo, additional, Oliveira, Isadora Sousa de, additional, Boldrini-França, Johara, additional, Pucca, Manuela Berto, additional, Baldo, Mateus Amaral, additional, and Arantes, Eliane Candiani, additional

Published
2020
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20. Beyond hemostasis: A potassium channel blocker snake venom serine protease with potential antitumor activity

Author

Boldrini-França, Johara, primary, Pinheiro-Junior, Ernesto Lopes, additional, Peigneur, Steve, additional, Costa, Tássia Rafaella, additional, Borges, Rafael Junqueira, additional, Pucca, Manuela Berto, additional, Cerni, Felipe Augusto, additional, Carone, Sante Emmanuel, additional, de Mattos Fontes, Marcos Roberto, additional, Sampaio, Suely Vilela, additional, Arantes, Eliane Candiani, additional, and Tytgat, Jan, additional

Published
2020
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23. Statement of Peer Review—Immersing in a Neglected Problem Inside the Amazon Jungle: Abstracts of the 1st International Symposium on Research in Venomous Animals, Manaus, Brazil †.

Author

Sachett, Jacqueline, Murta, Felipe, da Silva, Ana Maria Moura, de Farias, Altair Seabra, Kaefer, Igor Luis, Bisneto, Pedro, Cerni, Felipe Augusto, Carvalho, Érica da Silva, Rocha, Gisele Santos, Koolen, Hector, Machado, Vinícius Azevedo, Costa, Allyson Guimarães, Sampaio, Vanderson, Pucca, Manuela, Wen, Fan Hui, Sartim, Marco Aurélio, and Monteiro, Wuelton

Subjects
PEER review of students, LABORATORY animals, JUNGLES, CONFERENCES & conventions, EMAIL systems
Published
2023
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25. Experimental Lachesis muta rhombeata envenomation and effects of soursop (Annona muricata) as natural antivenom

Author

Cremonez, Caroline Marroni, primary, Leite, Flávia Pine, additional, Bordon, Karla de Castro Figueiredo, additional, Cerni, Felipe Augusto, additional, Cardoso, Iara Aimê, additional, Gregório, Zita Maria de Oliveira, additional, de Souza, Rodrigo Cançado Gonçalves, additional, de Souza, Ana Maria, additional, and Arantes, Eliane Candiani, additional

Published
2016
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29. Serrumab: A novel human single chain-fragment antibody with multiple scorpion toxin-neutralizing capacities.

Author

Pucca, Manuela Berto, Cerni, Felipe Augusto, Peigneur, Steve, Arantes, Eliane Candiani, Tytgat, Jan, and Barbosa, José Elpidio

Subjects
*IMMUNOGLOBULINS, *SCORPION venom, *PUBLIC health, *LEIURUS quinquestriatus, *BLOOD serum analysis, *ANTIVENINS
Abstract

In Brazil, scorpion envenomation is an important public health problem. The yellow scorpion, Tityus serrulatus (Ts), is considered the most dangerous species in the country, being responsible for the most severe clinical cases of envenomation. Currently, the administration of serum produced in horses is recognized and used as a treatment for accidents with scorpions. However, horse herds' maintenance is costly and the antibodies are heterologous, which can cause anaphylaxis and Serum Sickness. In the present work, a human monoclonal fragment antibody, Serrumab, has been analysed. Toxin neutralizing effects of Serrumab were evaluated using a two-electrode voltage-clamp technique. The results show that Serrumab presented a high neutralizing effect against Ts β-toxins (Ts1, 43.2% and Ts2, 68.8%) and none or low neutralizing effect against α-toxins (Ts3, 0% and Ts5, 10%). Additional experiments demonstrated that Serrumab was also able to neutralize the action of toxins from other scorpion genus (Css II, 45.96% and Lqh III, 100%/β- and α-toxins, respectively). This work indicated that Serrumab is able to neutralize many toxins in Ts venom, and could being considered as a neutralizing antibody for formulating a human anti-scorpion serum in Brazil. Additionally, this work demonstrated that Serrumab could neutralize different toxins from distinct scorpion genus. All these results reinforce the idea that Serrumab is a scFv antibody with multiple neutralizing capacities and a promising candidate for inclusion in scorpion anti-venoms against different genera. [ABSTRACT FROM AUTHOR]

Published
2014
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30. Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components.

Author

de Oliveira IS, Alano-da-Silva NM, Ferreira IG, Cerni FA, Sachett JAG, Monteiro WM, Pucca MB, and Arantes EC

Abstract

Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and β), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds' mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil., Competing Interests: Competing interests: The authors declare that they have no competing interests.

Published
2024
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