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1. Frontline immune checkpoint inhibitor-based combination therapy in metastatic renal cell carcinoma patients with poor performance status

Author

Carril-Ajuria, Lucía, Colomba, Emeline, Romero-Ferreiro, Carmen, Cerbone, Luigi, Ratta, Raffaele, Barthelemy, Philippe, Vindry, Clarisse, Fléchon, Aude, Cherifi, François, Boughalem, Elouen, Linassier, Claude, Fornarini, Giuseppe, Rebuzzi, Sara E., Gross-Goupil, Marine, Saldana, Carolina, Martin-Soberón, Maricruz, de Velasco, Guillermo, Manneh, Ray, Pernaut, Cristina, Sanchez de Torre, Ana, Flippot, Ronan, Escudier, Bernard, and Albiges, Laurence

Published
2023
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4. Pathological complete response in a patient with pleural mesothelioma treated with immunotherapy: a case report

Author

Faccioli, Eleonora, primary, Grosso, Federica, additional, Dell’Amore, Andrea, additional, Delfanti, Sara, additional, Zambello, Giovanni, additional, Cerbone, Luigi, additional, Canu, Gianluca, additional, De Angelis, Antonina, additional, Sambataro, Viola, additional, Pezzuto, Federica, additional, Barbieri, Paola, additional, Pasello, Giulia, additional, Calabrese, Fiorella, additional, and Rea, Federico, additional

Published
2024
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5. Liquid Biopsies for Circulating Tumor DNA Detection May Reveal Occult Hematologic Malignancies in Patients With Solid Tumors

Author

Aldea, Mihaela, Tagliamento, Marco, Bayle, Arnaud, Vasseur, Damien, Vergé, Véronique, Marinello, Arianna, Danlos, François-Xavier, Blanc-Durand, Felix, Bernard, Elsa, Cerbone, Luigi, Mosele, Maria Fernanda, Renneville, Aline, Hadoux, Julien, Loriot, Yohann, Sakkal, Madona, Vozy, Aurore, Sarkozy, Clementine, Smolenschi, Cristina, Nicotra, Claudio, Martin-Romano, Patricia, Boccon-Gibod, Clementine, Habza, Wafikaamira, Lazarovici, Julien, Ponce, Santiago, Hollebecque, Antoine, Marzac, Christophe, Lacroix, Ludovic, Barlesi, Fabrice, André, Fabrice, Besse, Benjamin, Rouleau, Etienne, Italiano, Antoine, and Micol, Jean-Baptiste

Published
2023
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6. Immunotherapy of mesothelioma: the evolving change of a long-standing therapeutic dream

Author

Calabrò, Luana, primary, Bronte, Giuseppe, additional, Grosso, Federica, additional, Cerbone, Luigi, additional, Delmonte, Angelo, additional, Nicolini, Fabio, additional, Mazza, Massimiliano, additional, Di Giacomo, Anna Maria, additional, Covre, Alessia, additional, Lofiego, Maria Fortunata, additional, Crinò, Lucio, additional, and Maio, Michele, additional

Published
2024
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12. Supplementary Tables S1-S11 from Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic Cancer

Author

Pradat, Yoann, primary, Viot, Julien, primary, Yurchenko, Andrey A., primary, Gunbin, Konstantin, primary, Cerbone, Luigi, primary, Deloger, Marc, primary, Grisay, Guillaume, primary, Verlingue, Loic, primary, Scott, Véronique, primary, Padioleau, Ismael, primary, Panunzi, Leonardo, primary, Michiels, Stefan, primary, Hollebecque, Antoine, primary, Jules-Clément, Gérôme, primary, Mezquita, Laura, primary, Lainé, Antoine, primary, Loriot, Yohann, primary, Besse, Benjamin, primary, Friboulet, Luc, primary, André, Fabrice, primary, Cournède, Paul-Henry, primary, Gautheret, Daniel, primary, and Nikolaev, Sergey I., primary

Published
2023
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13. Supplementary Figures S1-S24 from Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic Cancer

Author

Pradat, Yoann, primary, Viot, Julien, primary, Yurchenko, Andrey A., primary, Gunbin, Konstantin, primary, Cerbone, Luigi, primary, Deloger, Marc, primary, Grisay, Guillaume, primary, Verlingue, Loic, primary, Scott, Véronique, primary, Padioleau, Ismael, primary, Panunzi, Leonardo, primary, Michiels, Stefan, primary, Hollebecque, Antoine, primary, Jules-Clément, Gérôme, primary, Mezquita, Laura, primary, Lainé, Antoine, primary, Loriot, Yohann, primary, Besse, Benjamin, primary, Friboulet, Luc, primary, André, Fabrice, primary, Cournède, Paul-Henry, primary, Gautheret, Daniel, primary, and Nikolaev, Sergey I., primary

Published
2023
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14. Data from Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic Cancer

Author

Pradat, Yoann, primary, Viot, Julien, primary, Yurchenko, Andrey A., primary, Gunbin, Konstantin, primary, Cerbone, Luigi, primary, Deloger, Marc, primary, Grisay, Guillaume, primary, Verlingue, Loic, primary, Scott, Véronique, primary, Padioleau, Ismael, primary, Panunzi, Leonardo, primary, Michiels, Stefan, primary, Hollebecque, Antoine, primary, Jules-Clément, Gérôme, primary, Mezquita, Laura, primary, Lainé, Antoine, primary, Loriot, Yohann, primary, Besse, Benjamin, primary, Friboulet, Luc, primary, André, Fabrice, primary, Cournède, Paul-Henry, primary, Gautheret, Daniel, primary, and Nikolaev, Sergey I., primary

Published
2023
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15. Data from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Author

Fahrner, Jean-Eudes, primary, Lahmar, Imran, primary, Goubet, Anne-Gaëlle, primary, Haddad, Yacine, primary, Carrier, Agathe, primary, Mazzenga, Marine, primary, Drubay, Damien, primary, Alves Costa Silva, Carolina, primary, de Sousa, Eric, primary, Thelemaque, Cassandra, primary, Melenotte, Cléa, primary, Dubuisson, Agathe, primary, Geraud, Arthur, primary, Ferrere, Gladys, primary, Birebent, Roxanne, primary, Bigenwald, Camille, primary, Picard, Marion, primary, Cerbone, Luigi, primary, Lérias, Joana R., primary, Laparra, Ariane, primary, Bernard-Tessier, Alice, primary, Kloeckner, Benoît, primary, Gazzano, Marianne, primary, Danlos, François-Xavier, primary, Terrisse, Safae, primary, Pizzato, Eugenie, primary, Flament, Caroline, primary, Ly, Pierre, primary, Tartour, Eric, primary, Benhamouda, Nadine, primary, Meziani, Lydia, primary, Ahmed-Belkacem, Abdelhakim, primary, Miyara, Makoto, primary, Gorochov, Guy, primary, Barlesi, Fabrice, primary, Trubert, Alexandre, primary, Ungar, Benjamin, primary, Estrada, Yeriel, primary, Pradon, Caroline, primary, Gallois, Emmanuelle, primary, Pommeret, Fanny, primary, Colomba, Emeline, primary, Lavaud, Pernelle, primary, Deloger, Marc, primary, Droin, Nathalie, primary, Deutsch, Eric, primary, Gachot, Bertrand, primary, Spano, Jean-Philippe, primary, Merad, Mansouria, primary, Scotté, Florian, primary, Marabelle, Aurélien, primary, Griscelli, Frank, primary, Blay, Jean-Yves, primary, Soria, Jean-Charles, primary, Merad, Miriam, primary, André, Fabrice, primary, Villemonteix, Juliette, primary, Chevalier, Mathieu F., primary, Caillat-Zucman, Sophie, primary, Fenollar, Florence, primary, Guttman-Yassky, Emma, primary, Launay, Odile, primary, Kroemer, Guido, primary, La Scola, Bernard, primary, Maeurer, Markus, primary, Derosa, Lisa, primary, and Zitvogel, Laurence, primary

Published
2023
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16. Abstract 6570: Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer

Author

Pradat, Yoann, primary, Viot, Julien, additional, Gunbin, Konstantin, additional, Yurchenko, Andrey, additional, Cerbone, Luigi, additional, Deloger, Marc, additional, Grisay, Guillaume, additional, Verlingue, Loic, additional, Scott, Véronique, additional, Padioleau, Ismael, additional, Panunzi, Leonardo, additional, Michiels, Stefan, additional, Hollebecque, Antoine, additional, Jules-Clément, Gerome, additional, Mezquita, Laura, additional, Lainé, Antoine, additional, Loriot, Yohann, additional, Besse, Benjamin, additional, Friboulet, Luc, additional, André, Fabrice, additional, Cournède, Paul-Henry, additional, Gautheret, Daniel, additional, and Nikolaev, Sergey, additional

Published
2023
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17. Supplementary Data from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Author

Fahrner, Jean-Eudes, primary, Lahmar, Imran, primary, Goubet, Anne-Gaëlle, primary, Haddad, Yacine, primary, Carrier, Agathe, primary, Mazzenga, Marine, primary, Drubay, Damien, primary, Alves Costa Silva, Carolina, primary, de Sousa, Eric, primary, Thelemaque, Cassandra, primary, Melenotte, Cléa, primary, Dubuisson, Agathe, primary, Geraud, Arthur, primary, Ferrere, Gladys, primary, Birebent, Roxanne, primary, Bigenwald, Camille, primary, Picard, Marion, primary, Cerbone, Luigi, primary, Lérias, Joana R., primary, Laparra, Ariane, primary, Bernard-Tessier, Alice, primary, Kloeckner, Benoît, primary, Gazzano, Marianne, primary, Danlos, François-Xavier, primary, Terrisse, Safae, primary, Pizzato, Eugenie, primary, Flament, Caroline, primary, Ly, Pierre, primary, Tartour, Eric, primary, Benhamouda, Nadine, primary, Meziani, Lydia, primary, Ahmed-Belkacem, Abdelhakim, primary, Miyara, Makoto, primary, Gorochov, Guy, primary, Barlesi, Fabrice, primary, Trubert, Alexandre, primary, Ungar, Benjamin, primary, Estrada, Yeriel, primary, Pradon, Caroline, primary, Gallois, Emmanuelle, primary, Pommeret, Fanny, primary, Colomba, Emeline, primary, Lavaud, Pernelle, primary, Deloger, Marc, primary, Droin, Nathalie, primary, Deutsch, Eric, primary, Gachot, Bertrand, primary, Spano, Jean-Philippe, primary, Merad, Mansouria, primary, Scotté, Florian, primary, Marabelle, Aurélien, primary, Griscelli, Frank, primary, Blay, Jean-Yves, primary, Soria, Jean-Charles, primary, Merad, Miriam, primary, André, Fabrice, primary, Villemonteix, Juliette, primary, Chevalier, Mathieu F., primary, Caillat-Zucman, Sophie, primary, Fenollar, Florence, primary, Guttman-Yassky, Emma, primary, Launay, Odile, primary, Kroemer, Guido, primary, La Scola, Bernard, primary, Maeurer, Markus, primary, Derosa, Lisa, primary, and Zitvogel, Laurence, primary

Published
2023
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18. Supplementary Figure from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Author

Fahrner, Jean-Eudes, primary, Lahmar, Imran, primary, Goubet, Anne-Gaëlle, primary, Haddad, Yacine, primary, Carrier, Agathe, primary, Mazzenga, Marine, primary, Drubay, Damien, primary, Alves Costa Silva, Carolina, primary, de Sousa, Eric, primary, Thelemaque, Cassandra, primary, Melenotte, Cléa, primary, Dubuisson, Agathe, primary, Geraud, Arthur, primary, Ferrere, Gladys, primary, Birebent, Roxanne, primary, Bigenwald, Camille, primary, Picard, Marion, primary, Cerbone, Luigi, primary, Lérias, Joana R., primary, Laparra, Ariane, primary, Bernard-Tessier, Alice, primary, Kloeckner, Benoît, primary, Gazzano, Marianne, primary, Danlos, François-Xavier, primary, Terrisse, Safae, primary, Pizzato, Eugenie, primary, Flament, Caroline, primary, Ly, Pierre, primary, Tartour, Eric, primary, Benhamouda, Nadine, primary, Meziani, Lydia, primary, Ahmed-Belkacem, Abdelhakim, primary, Miyara, Makoto, primary, Gorochov, Guy, primary, Barlesi, Fabrice, primary, Trubert, Alexandre, primary, Ungar, Benjamin, primary, Estrada, Yeriel, primary, Pradon, Caroline, primary, Gallois, Emmanuelle, primary, Pommeret, Fanny, primary, Colomba, Emeline, primary, Lavaud, Pernelle, primary, Deloger, Marc, primary, Droin, Nathalie, primary, Deutsch, Eric, primary, Gachot, Bertrand, primary, Spano, Jean-Philippe, primary, Merad, Mansouria, primary, Scotté, Florian, primary, Marabelle, Aurélien, primary, Griscelli, Frank, primary, Blay, Jean-Yves, primary, Soria, Jean-Charles, primary, Merad, Miriam, primary, André, Fabrice, primary, Villemonteix, Juliette, primary, Chevalier, Mathieu F., primary, Caillat-Zucman, Sophie, primary, Fenollar, Florence, primary, Guttman-Yassky, Emma, primary, Launay, Odile, primary, Kroemer, Guido, primary, La Scola, Bernard, primary, Maeurer, Markus, primary, Derosa, Lisa, primary, and Zitvogel, Laurence, primary

Published
2023
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19. Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic Cancer

Author

Pradat, Yoann, primary, Viot, Julien, additional, Yurchenko, Andrey A., additional, Gunbin, Konstantin, additional, Cerbone, Luigi, additional, Deloger, Marc, additional, Grisay, Guillaume, additional, Verlingue, Loic, additional, Scott, Véronique, additional, Padioleau, Ismael, additional, Panunzi, Leonardo, additional, Michiels, Stefan, additional, Hollebecque, Antoine, additional, Jules-Clément, Gérôme, additional, Mezquita, Laura, additional, Lainé, Antoine, additional, Loriot, Yohann, additional, Besse, Benjamin, additional, Friboulet, Luc, additional, André, Fabrice, additional, Cournède, Paul-Henry, additional, Gautheret, Daniel, additional, and Nikolaev, Sergey I., additional

Published
2023
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21. The Lung Immune Prognostic Index (LIPI) stratifies prognostic groups and correlates with gut microbiota (GM) in patients with advanced renal cell carcinoma (RCC).

Author

Silva, Carolina Alves Costa, primary, Zoppi, Silvia, additional, Reni, Anna, additional, Piccinno, Gianmarco, additional, Lahmar, Imran, additional, Cerbone, Luigi, additional, Carril-Ajuria, Lucía, additional, Colomba, Emeline, additional, Flippot, Ronan, additional, Sow, Cissé, additional, Segata, Nicola, additional, Escudier, Bernard, additional, Zitvogel, Laurence, additional, Albiges, Laurence, additional, and Derosa, Lisa, additional

Published
2023
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22. Abstract PR009: Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer

Author

Pradat, Yoann, primary, Viot, Julien, additional, Gunbin, Konstantin, additional, Iurchenko, Andrei, additional, Deloger, Marc, additional, Cerbone, Luigi, additional, Grisay, Guillaume, additional, Verlingue, Loic, additional, Scott, Veronique, additional, Michiels, Stefan, additional, Hollebecque, Antoine, additional, Jules-Clement, Gerome, additional, Laine, Antoine, additional, Friboulet, Luc, additional, Mezquita, Laura, additional, Loriot, Yohann, additional, Besse, Benjamin, additional, Andre, Fabrice, additional, Cournede, Paul-Henry, additional, Gautheret, Daniel, additional, and Nikolaev, Sergey, additional

Published
2023
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23. Unprecedented long‐term survival in a patient with malignant pleural mesothelioma treated with subsequent systemic chemo‐ and immunotherapeutic regimens

Author

Cerbone, Luigi, primary, Delfanti, Sara, additional, De Angelis, Antonina M., additional, Crivellari, Stefania, additional, Boccuzzi, Francesco, additional, Cimorelli, Angela, additional, Bertolotti, Marinella, additional, Righi, Luisella, additional, Bertino, Pietro, additional, and Grosso, Federica, additional

Published
2023
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24. Combined Response of Advanced Cutaneous Squamous Cell Carcinoma and Renal Cell Carcinoma to Immunotherapy: A Case Report

Author

Murianni, Veronica, primary, Cerbone, Luigi, additional, Rescigno, Pasquale, additional, Catalano, Fabio, additional, Damassi, Alessandra, additional, Cremante, Malvina, additional, Gandini, Annalice, additional, Puglisi, Silvia, additional, Pesola, Guido, additional, Banna, Giuseppe Luigi, additional, Buti, Sebastiano, additional, Signori, Alessio, additional, Fornarini, Giuseppe, additional, and Rebuzzi, Sara Elena, additional

Published
2022
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26. Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer

Author

Pradat, Yoann, primary, Viot, Julien, additional, Gunbin, Konstantin, additional, Yurchenko, Andrey, additional, Cerbone, Luigi, additional, Deloger, Marc, additional, Grisay, Guillaume, additional, Verlingue, Loic, additional, Scott, Véronique, additional, Padioleau, Ismael, additional, Panunzi, Leonardo, additional, Michiels, Stefan, additional, Hollebecque, Antoine, additional, Jules-Clément, Gérôme, additional, Mezquita, Laura, additional, Lainé, Antoine, additional, Loriot, Yohann, additional, Besse, Benjamin, additional, Friboulet, Luc, additional, André, Fabrice, additional, Cournède, Paul-Henry, additional, Gautheret, Daniel, additional, and Nikolaev, Sergey, additional

Published
2022
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28. Efficacy of first-line combination therapy in metastatic renal cell carcinoma (mRCC) patients (pts) with poor performance status (PS).

Author

Carril, Lucia, primary, Colomba, Emeline, additional, Romero-Ferreiro, Carmen, additional, Cerbone, Luigi, additional, Ratta, Raffaele, additional, Barthélémy, Philippe, additional, Vindry, Clarisse, additional, Cherifi, Francois, additional, Boughalem, Elouen, additional, Linassier, Claude, additional, Fornarini, Giuseppe, additional, Gross-Goupil, Marine, additional, Saldana, Carolina, additional, Martin Soberón, Maria Cruz, additional, de Velasco, Guillermo, additional, Pernaut, Cristina, additional, Alves Costa Silva, Carolina, additional, Flippot, Ronan, additional, Escudier, Bernard, additional, and Albiges, Laurence, additional

Published
2022
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29. Application of the Meet-URO score to metastatic renal cell carcinoma patients treated with second- and third-line cabozantinib

Author

Rebuzzi, Sara Elena, primary, Cerbone, Luigi, additional, Signori, Alessio, additional, Santoni, Matteo, additional, Murianni, Veronica, additional, De Giorgi, Ugo, additional, Procopio, Giuseppe, additional, Porta, Camillo, additional, Milella, Michele, additional, Basso, Umberto, additional, Massari, Francesco, additional, Maruzzo, Marco, additional, Iacovelli, Roberto, additional, Battelli, Nicola, additional, Carmisciano, Luca, additional, Banna, Giuseppe Luigi, additional, Buti, Sebastiano, additional, and Fornarini, Giuseppe, additional

Published
2022
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30. Durable response after immunotherapy discontinuation for delayed and severe immune-related adverse events: a case report

Author

Pesola, Guido, primary, Murianni, Veronica, additional, Rebuzzi, Sara Elena, additional, Banna, Giuseppe Luigi, additional, Cerbone, Luigi, additional, Catalano, Fabio, additional, Borea, Roberto, additional, Gandini, Annalice, additional, Cremante, Malvina, additional, Puglisi, Silvia, additional, Trovato, Francesco, additional, and Fornarini, Giuseppe, additional

Published
2021
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31. Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients

Author

Bourgin, Mélanie, primary, Derosa, Lisa, additional, Silva, Carolina Alves Costa, additional, Goubet, Anne-Gaëlle, additional, Dubuisson, Agathe, additional, Danlos, François-Xavier, additional, Grajeda-Iglesias, Claudia, additional, Cerbone, Luigi, additional, Geraud, Arthur, additional, Laparra, Ariane, additional, Aprahamian, Fanny, additional, Nirmalathasan, Nitharsshini, additional, Madeo, Frank, additional, Zitvogel, Laurence, additional, Kroemer, Guido, additional, and Durand, Sylvère, additional

Published
2021
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32. Response to systemic therapy in fumarate hydratase–deficient renal cell carcinoma

Author

Carril-Ajuria, Lucia, primary, Colomba, Emeline, additional, Cerbone, Luigi, additional, Romero-Ferreiro, Carmen, additional, Crouzet, Laurence, additional, Laguerre, Brigitte, additional, Thibault, Constance, additional, Vicier, Cécile, additional, de Velasco, Guillermo, additional, Fléchon, Aude, additional, Saldana, Carolina, additional, Benusiglio, Patrick R., additional, Bressac-de Paillerets, Brigitte, additional, Guillaud-Bataille, Marine, additional, Gaignard, Pauline, additional, Scoazec, Jean-Yves, additional, Richard, Stéphane, additional, Caron, Olivier, additional, Escudier, Bernard, additional, and Albiges, Laurence, additional

Published
2021
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33. The Effect of Concomitant Proton Pump Inhibitor and Cabozantinib on the Outcomes of Patients with Metastatic Renal Cell Carcinoma

Author

Rassy, Elie, primary, Cerbone, Luigi, additional, Auclin, Edouard, additional, Benchimoll-Zouari, Axelle, additional, Flippot, Ronan, additional, Alves Costa Silva, Carolina, additional, Colomba, Emeline, additional, Geraud, Arthur, additional, Guida, Annalisa, additional, Mir, Olivier, additional, Combarel, David, additional, Paci, Angelo, additional, Escudier, Bernard, additional, and Albiges, Laurence, additional

Published
2021
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35. Association of cabozantinib residual concentration (Ctrough) and blood clearance (Cl/F) with toxicity (tox) and progressive disease (PD) in metastatic renal cell carcinoma (mRCC) patients (pts): Results from a monocentric pharmacokinetics (PK) study.

Author

Cerbone, Luigi, primary, Combarel, David, additional, Foulon, Stéphanie, additional, Geraud, Arthur, additional, Alves, Carolina, additional, Colomba, Emeline, additional, Carril, Lucia, additional, Derosa, Lisa, additional, Flippot, Ronan, additional, Mir, Olivier, additional, Escudier, Bernard, additional, Paci, Angelo, additional, and Albiges, Laurence, additional

Published
2021
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42. Prognostic variables in localized small cell neuroendocrine carcinoma of the bladder: A population-based study.

Author

Cattrini, Carlo, primary, Cerbone, Luigi, additional, Rubagotti, Alessandra, additional, Zinoli, Linda, additional, Latocca, Maria Maddalena, additional, Buzzatti, Giulia, additional, Vallome, Giacomo, additional, Rizzo, Fabio, additional, Cavo, Alessia, additional, Beshiri, Kristi, additional, Soldato, Davide, additional, Messina, Carlo, additional, Zanardi, Elisa, additional, and Boccardo, Francesco, additional

Published
2018
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43. Nivolumab in pretreated pleural mesothelioma: Results from an observational real-world study of patients treated within the AIFA 5% Fund

Author

Cerbone, Luigi, Delfanti, Sara, Crivellari, Stefania, De Angelis, Antonina Maria, Mazzeo, Laura, Proto, Claudia, Occhipinti, Mario, Lo Russo, Giuseppe, Dellepiane, Chiara, Biello, Federica, Alabiso, Irene, Verderame, Francesco, Gauna, Roberta, De Simone, Irene, Cuppone, Federica, Petraglia, Sandra, Pasello, Giulia, Ceresoli, Giovanni Luca, Garassino, Marina Chiara, Torri, Valter, and Grosso, Federica

Abstract

Background: Pleural mesothelioma is a rare cancer with a dismal prognosis and few therapeutic options, especially in the pretreated setting. Immunotherapy with checkpoint inhibitors as single agents yielded interesting results in refractory pleural mesothelioma, achieving a response rate between 10-20%, median progression-free survival of 2-5 months and median overall survival of 7-13 months.Patients and methods: A retrospective, multi-institutional study of pleural mesothelioma patients treated with nivolumab in second and further line was performed. The endpoints of the study are response rate, disease control rate, progression free survival and overall survival.Results: Sixty-five patients with pleural mesothelioma treated with nivolumab in second and further line were enrolled at seven Italian institutions. The response rate was 8%, disease control rate was 37%, median progression free survival was 5.7 months (95% CI: 2.9-9.0) and median overall survival was 11.1 (95% CI 6.2-19.9) months. A higher neutrophils and neutrophils to lymphocytes ratio at baseline were associated with worse prognosis.Conclusion: Nivolumab as a single agent is fairly active in a cohort of unselected pretreated pleural mesothelioma patients. Further investigations on clinical and translational factors are needed to define which patient might benefit most from nivolumab treatment in pleural mesothelioma.

Published
2024
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44. The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals.

Author

Fahrner JE, Lahmar I, Goubet AG, Haddad Y, Carrier A, Mazzenga M, Drubay D, Alves Costa Silva C, de Sousa E, Thelemaque C, Melenotte C, Dubuisson A, Geraud A, Ferrere G, Birebent R, Bigenwald C, Picard M, Cerbone L, Lérias JR, Laparra A, Bernard-Tessier A, Kloeckner B, Gazzano M, Danlos FX, Terrisse S, Pizzato E, Flament C, Ly P, Tartour E, Benhamouda N, Meziani L, Ahmed-Belkacem A, Miyara M, Gorochov G, Barlesi F, Trubert A, Ungar B, Estrada Y, Pradon C, Gallois E, Pommeret F, Colomba E, Lavaud P, Deloger M, Droin N, Deutsch E, Gachot B, Spano JP, Merad M, Scotté F, Marabelle A, Griscelli F, Blay JY, Soria JC, Merad M, André F, Villemonteix J, Chevalier MF, Caillat-Zucman S, Fenollar F, Guttman-Yassky E, Launay O, Kroemer G, La Scola B, Maeurer M, Derosa L, and Zitvogel L

Subjects
Antibodies, Neutralizing, Humans, SARS-CoV-2, Spike Glycoprotein, Coronavirus chemistry, Spike Glycoprotein, Coronavirus genetics, Antiviral Restriction Factors immunology, COVID-19 immunology, Neoplasms complications, T-Lymphocytes immunology
Abstract

Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized the polarity and specificity of memory T cells directed against SARS-CoV-2 viral lysates and peptides to determine correlates with spontaneous, virus-elicited, or vaccine-induced protection against COVID-19 in disease-free and cancer-bearing individuals. A disbalance between type 1 and 2 cytokine release was associated with high susceptibility to COVID-19. Individuals susceptible to infection exhibited a specific deficit in the T helper 1/T cytotoxic 1 (Th1/Tc1) peptide repertoire affecting the receptor binding domain of the spike protein (S1-RBD), a hotspot of viral mutations. Current vaccines triggered Th1/Tc1 responses in only a fraction of all subject categories, more effectively against the original sequence of S1-RBD than that from viral variants. We speculate that the next generation of vaccines should elicit Th1/Tc1 T-cell responses against the S1-RBD domain of emerging viral variants., Significance: This study prospectively analyzed virus-specific T-cell correlates of protection against COVID-19 in healthy and cancer-bearing individuals. A disbalance between Th1/Th2 recall responses conferred susceptibility to COVID-19 in both populations, coinciding with selective defects in Th1 recognition of the receptor binding domain of spike. See related commentary by McGary and Vardhana, p. 892. This article is highlighted in the In This Issue feature, p. 873., (©2022 The Authors; Published by the American Association for Cancer Research.)

Published
2022
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