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17 results on '"Cepaitis, Z."'

1. The contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: The MORGAM Project Cohort Component

Author

Ferrario, Marco M, Veronesi, Giovanni, Chambless, Lloyd E, Tunstall-Pedoe, Hugh, Kuulasmaa, Kari, Salomaa, Veikko, Borglykke, Anders, Hart, Nigel, Söderberg, Stefan, Cesana, Giancarlo, Jørgensen, T., Agger, C., Borglykke, A., Salomaa, V., Juolevi, A., Vartiainen, E., Jousilahti, P., Kuulasmaa, K., Cepaitis, Z., Haukijärvi, A., Joseph, B.J, Kulathinal, S., Niemelä, M., Saarela, O., Ducimetière, P., Bingham, A., Arveiler, D., Haas, B., Wagner, A., Ferrières, J., Ruidavets, J-B., Bongard, V., Amouyel, P., Montaye, M., Dallongeville, J., Döring, A., Wichmann, E., Ferrario, M., Ferrario, M., Veronesi, G., Cesana, G., Fornari, C., Sega, R., Mancia, G., Facchetti, R., Vanuzzo, D., Pilotto, L., Picco, F., Mattiussi, F., Gigante, S., Tamosiunas, A., Domarkiene, S., Rastenyte, D., Bernotiene, G., Radisauskas, R., Baceviciene, M., Luksiene, D., Malinauskiene, V., Bernotaite, L., Pająk, A., Kawalec, E., Broda, G., Kurjata, P., Rywik, S.L., Polakowska, M., Pytlak, A., Nikitin, Yu., Malyutina, S., Gafarov, V., Feigin, V., Siminova, G., Voevoda, M., Vinogradova, T., Nasonova, N., Veriovkin, E., Eliasson, M., Söderberg, S., Stegmayr, B., Eriksson, M., Asplund, K., Kee, F, Evans, A., Yarnell, J., Gardner, E., Tunstall-Pedoe, H., Woodward, M, Evans, A., Cashman, S., Evans, A., Blankenberg, S., Ferrario, M., Kee, F., Kuulasmaa, K., Palotie, A., Perola, M., Peters, A., Salomaa, V., Tregouet, D., Tunstall-Pedoe, H., Asplund, K., Cambien, F., Tiret, L, Peltonen, L., Shields, D., Stegmayr, B., and Wiklund, P.-G.

Published
2014
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3. The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project

Author

Hobbs, MST, Jamrozik, K., Thompson, PL, Armstrong, BK, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L., De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L., Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, HE, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F., Beck, D, Wunsch, G., Bertrand, F., van Houte, M., Rime, B., Rorive, G, Hannot, R., Adrienne, A, Luyckx, A, Wolf, HK, Gregor, RD, Bata, IR, Brownell, B., Webber, K, Skodova´, Z, Pisa, Z., Berka, L., Cicha, Z., Cerovska´, J, Emrova´, R, Hoke, M, Hronkova, M., Pikhartova´, J., Grafnetter, D., Poledne, R., Vojtisek, P., Vorlicek, J., Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A., Quitsau Lund, S, Tuomilehto, J, Puska, P., Vartiainen, E., Korhonen, H., Jousilahti, M, Ducimetie`re, P, Richard, JL, Bingham, A., Lang, T, Amouyel, P, Cottel, D., Nuttens, MC, Marecaux, N., Dallongeville, J., Salomez, J. L., Montaye, M., Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N., Savouret, M, Houset, M., Pierau, F., Goetz, V, Ferrie`res, J, Ruidavets, JB, Cambou, JP, Rodier, P., Saulet, C, Greiser, E., Herman, B., Stu¨demann, G, Nu¨ssel, E., Osto¨r Lamm, E., Scheidt, R., Morgenstern, W., Stadler, M, Ganova, M, Keil, U, Tietze, M., Banos, R., Do¨ring, A., Filipiak, B, Barth, W, Heinemann, L, Muche, J., Schmalfuss, S., Assmann, A., Bo¨thig, S., Voigt, G., Brasche, S., Quietzsch, D., Classen, E, Sigfu´sson, N, Gudmundsdo´ttir, II, Stefa´nsdo´ttir, I, Thorsteinsson, T., Sigvaldason H, Menotti, A, Giampaoli, S., Verdecchia, A, Righetti, G., De Pasquale, B., Di Raimo, P, Forte, E., Majetta, A, Vanuzzo, D, Feruglio, GA, Pilotto, L., Cignacco, G., Marini, R., Zilio, G, Cesana, GC, Ferrario, M, Sega, R., Mocarelli, P, BRAMBILLA, PAOLO, Bluzhas, J, Domarkiene, S., Tamosiunas, A., Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A., Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E., Pazucha, T., Malczewska, M., Mo´rawska, I, Rywik, SL, Broda,V, Polakowska, M., Kurjata, P, Varlamova, A, Britov, A., Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y.u. P, Malyutina, S., Gafarov, V, Feigin, V, Sans, S., Balaguer Vintro´, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode´s, A, Wilhelmsen, L, Harmsen, P., Rosengren, A., Lappas, G, Asplund, K., Huhtasaari, F., Stegmayr, B., Lundberg V, Gutzwiller, F, Paccaud, F., Rickenbach, M., Wietlisbach, V., Barazzoni, F, Mainieri, F., Tullen, B, Evans, V, McCrum, EE, Falconer, T, Cashman, S., Patterson, C., Kerr, M., O’Reilly, D., Scott, A., McConville, M., McMillan, I., McMaster, D, Tunstall Pedoe, H., Smith, WCS, Tavendale, R., Crombie, V, Barrett, K., Brown, C., Shewry, M., Hannh, M. K, Morrisson, C, Planojevic, M, Jakovljevic, D., Svircevic, A., Mirilov, V., Strasser, V., Mendis, S., Martin8, I, Gyarfas8, V, Pı´_sa8, V, Dodu8, S. R. A., Bo¨thig8, S., Watson, M. J., Hill, M., Price, A, Kuulasmaa, K., Tuomilehto, J., Ruokokoski, E, Rajakangas, A. M., Ma¨kinen, M., Virman Ojanen, T, Palonen, L., Akkila, J, Cepaitis, Z., Molarius, A., Moltchanov, V., Tolonen, H, Grafnetter, D, Dobson, A., Fortmann, SP, Shatchkute, A, Zaitsev, V, Epstein, FH, Feinleib, M, Karvonen, MJ, Prineas, RJ, Williams, OD, Hobbs, M, Jamrozik, K, Thompson, P, Armstrong, B, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L, De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L, Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, H, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F, Beck, D, Wunsch, G, Bertrand, F, van Houte, M, Rime, B, Rorive, G, Hannot, R, Adrienne, A, Luyckx, A, Wolf, H, Gregor, R, Bata, I, Brownell, B, Webber, K, Skodova´, Z, Pisa, Z, Berka, L, Cicha, Z, Cerovska´, J, Emrova´, R, Hoke, M, Hronkova, M, Pikhartova´, J, Grafnetter, D, Poledne, R, Vojtisek, P, Vorlicek, J, Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A, Quitsau Lund, S, Tuomilehto, J, Puska, P, Vartiainen, E, Korhonen, H, Jousilahti, M, Ducimetie`re, P, Richard, J, Bingham, A, Lang, T, Amouyel, P, Cottel, D, Nuttens, M, Marecaux, N, Dallongeville, J, Salomez, J, Montaye, M, Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N, Savouret, M, Houset, M, Pierau, F, Goetz, V, Ferrie`res, J, Ruidavets, J, Cambou, J, Rodier, P, Saulet, C, Greiser, E, Herman, B, Stu¨demann, G, Nu¨ssel, E, Osto¨r Lamm, E, Scheidt, R, Morgenstern, W, Stadler, M, Ganova, M, Keil, U, Tietze, M, Banos, R, Do¨ring, A, Filipiak, B, Barth, W, Heinemann, L, Muche, J, Schmalfuss, S, Assmann, A, Bo¨thig, S, Voigt, G, Brasche, S, Quietzsch, D, Classen, E, Sigfu´sson, N, Gudmundsdo´ttir, I, Stefa´nsdo´ttir, I, Thorsteinsson, T, Sigvaldason, H, Menotti, A, Giampaoli, S, Verdecchia, A, Righetti, G, De Pasquale, B, Di Raimo, P, Forte, E, Majetta, A, Vanuzzo, D, Feruglio, G, Pilotto, L, Cignacco, G, Marini, R, Zilio, G, Cesana, G, Ferrario, M, Sega, R, Mocarelli, P, Brambilla, P, Bluzhas, J, Domarkiene, S, Tamosiunas, A, Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A, Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E, Pazucha, T, Malczewska, M, Mo´rawska, I, Rywik, S, Broda, V, Polakowska, M, Kurjata, P, Varlamova, A, Britov, A, Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y, Malyutina, S, Gafarov, V, Feigin, V, Sans, S, Balaguer Vintro´, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode´s, A, Wilhelmsen, L, Harmsen, P, Rosengren, A, Lappas, G, Asplund, K, Huhtasaari, F, Stegmayr, B, Lundberg, V, Gutzwiller, F, Paccaud, F, Rickenbach, M, Wietlisbach, V, Barazzoni, F, Mainieri, F, Tullen, B, Evans, V, Mccrum, E, Falconer, T, Cashman, S, Patterson, C, Kerr, M, O’Reilly, D, Scott, A, Mcconville, M, Mcmillan, I, Mcmaster, D, Tunstall Pedoe, H, Smith, W, Tavendale, R, Crombie, V, Barrett, K, Brown, C, Shewry, M, Hannh, M, Morrisson, C, Planojevic, M, Jakovljevic, D, Svircevic, A, Mirilov, V, Strasser, V, Mendis, S, Martin8, I, Gyarfas8, V, Pı´_sa8, V, Dodu8, S, Bo¨thig8, S, Watson, M, Hill, M, Price, A, Kuulasmaa, K, Ruokokoski, E, Rajakangas, A, Ma¨kinen, M, Virman Ojanen, T, Palonen, L, Akkila, J, Cepaitis, Z, Molarius, A, Moltchanov, V, Tolonen, H, Dobson, A, Fortmann, S, Shatchkute, A, Zaitsev, V, Epstein, F, Feinleib, M, Karvonen, M, Prineas, R, and Williams, O

Subjects
Adult, Male, Canada, medicine.medical_specialty, BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, Waist, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Logistic regression, Body Mass Index, Risk Factors, Internal medicine, Prevalence, medicine, Humans, Triglycerides, Abdominal obesity, Adiposity, Dyslipidemias, Nutrition and Dietetics, business.industry, Cholesterol, HDL, Smoking, Australia, nutritional and metabolic diseases, Cholesterol, LDL, Middle Aged, medicine.disease, Health Surveys, Europe, Menopause, Cross-Sectional Studies, Logistic Models, Endocrinology, Dyslipidemia, Quartile, Obesity, Abdominal, Female, Waist Circumference, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Body mass index, New Zealand, Demography
Abstract

Background and aims: The association between adiposity measures and dyslipidemia has seldom been assessed in a multipopulational setting. Methods and results: 27 populations from Europe, Australia, New Zealand and Canada (WHO MONICA project) using health surveys conducted between 1990 and 1997 in adults aged 35-64 years (n = 40,480). Dyslipidemia was defined as the total/HDL cholesterol ratio >6 (men) and >5 (women).Overall prevalence of dyslipidemia was 25% in men and 23% in women. Logistic regression showed that dyslipidemia was strongly associated with body mass index (BMI) in men and with waist circumference (WC) in women, after adjusting for region, age and smoking. Among normal-weight men and women (BMI84.8 cm) in normal-weight men, menopause in women and regular smoking further defined subgroups at increased risk. Conclusion: standard categories of BMI and WC, or their combinations, do not lead to optimal risk stratification for dyslipidemia in middle-age adults. Sex-specific adaptations are necessary, in particular by taking into account abdominal obesity in normal-weight men, post-menopausal age in women and regular smoking in both sexes

Published
2013
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4. The relation of body mass index and abdominal adiposity with dyslipidemia in 27 general populations of the WHO MONICA Project

Author

Hobbs, M, Jamrozik, K, Thompson, P, Armstrong, B, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L, De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L, Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, H, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F, Beck, D, Wunsch, G, Bertrand, F, van Houte, M, Rime, B, Rorive, G, Hannot, R, Adrienne, A, Luyckx, A, Wolf, H, Gregor, R, Bata, I, Brownell, B, Webber, K, Skodova ́, Z, Pisa, Z, Berka, L, Cicha, Z, Cerovska ́, J, Emrova ́, R, Hoke, M, Hronkova, M, Pikhartova ́, J, Grafnetter, D, Poledne, R, Vojtisek, P, Vorlicek, J, Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A, Quitsau Lund, S, Tuomilehto, J, Puska, P, Vartiainen, E, Korhonen, H, Jousilahti, M, Ducimetie`re, P, Richard, J, Bingham, A, Lang, T, Amouyel, P, Cottel, D, Nuttens, M, Marecaux, N, Dallongeville, J, Salomez, J, Montaye, M, Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N, Savouret, M, Houset, M, Pierau, F, Goetz, V, Ferrie`res, J, Ruidavets, J, Cambou, J, Rodier, P, Saulet, C, Greiser, E, Herman, B, Stu ̈demann, G, Nu ̈ssel, E, Osto ̈r Lamm, E, Scheidt, R, Morgenstern, W, Stadler, M, Ganova, M, Keil, U, Tietze, M, Banos, R, Do ̈ring, A, Filipiak, B, Barth, W, Heinemann, L, Muche, J, Schmalfuss, S, Assmann, A, Bo ̈thig, S, Voigt, G, Brasche, S, Quietzsch, D, Classen, E, Sigfu ́sson, N, Gudmundsdo ́ttir, I, Stefa ́nsdo ́ttir, I, Thorsteinsson, T, Sigvaldason, H, Menotti, A, Giampaoli, S, Verdecchia, A, Righetti, G, De Pasquale, B, Di Raimo, P, Forte, E, Majetta, A, Vanuzzo, D, Feruglio, G, Pilotto, L, Cignacco, G, Marini, R, Zilio, G, Cesana, G, Ferrario, M, Sega, R, Mocarelli, P, Brambilla, P, Bluzhas, J, Domarkiene, S, Tamosiunas, A, Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A, Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E, Pazucha, T, Malczewska, M, Mo ́rawska, I, Rywik, S, Broda, V, Polakowska, M, Kurjata, P, Varlamova, A, Britov, A, Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y, Malyutina, S, Gafarov, V, Feigin, V, Sans, S, Balaguer Vintro ́, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode ́s, A, Wilhelmsen, L, Harmsen, P, Rosengren, A, Lappas, G, Asplund, K, Huhtasaari, F, Stegmayr, B, Lundberg, V, Gutzwiller, F, Paccaud, F, Rickenbach, M, Wietlisbach, V, Barazzoni, F, Mainieri, F, Tullen, B, Evans, V, Mccrum, E, Falconer, T, Cashman, S, Patterson, C, Kerr, M, O’Reilly, D, Scott, A, Mcconville, M, Mcmillan, I, Mcmaster, D, Tunstall Pedoe, H, Smith, W, Tavendale, R, Crombie, V, Barrett, K, Brown, C, Shewry, M, Hannh, M, Morrisson, C, Planojevic, M, Jakovljevic, D, Svircevic, A, Mirilov, V, Strasser, V, Mendis, S, Martin8, I, Gyarfas8, V, Pı ́_sa8, V, Dodu8, S, Bo ̈thig8, S, Watson, M, Hill, M, Price, A, Kuulasmaa, K, Ruokokoski, E, Rajakangas, A, Ma ̈kinen, M, Virman Ojanen, T, Palonen, L, Akkila, J, Cepaitis, Z, Molarius, A, Moltchanov, V, Tolonen, H, Dobson, A, Fortmann, S, Shatchkute, A, Zaitsev, V, Epstein, F, Feinleib, M, Karvonen, M, Prineas, R, Williams, O, Hobbs, MST, Jamrozik, K., Thompson, PL, Armstrong, BK, Van Parys, L., Berghmans, L., Kulbertus, HE, Lefebvre, F., Wunsch, G., Bertrand, F., van Houte, M., Rime, B., Hannot, R., Wolf, HK, Gregor, RD, Bata, IR, Brownell, B., Pisa, Z., Berka, L., Cicha, Z., Hronkova, M., Pikhartova ́, J., Grafnetter, D., Poledne, R., Vojtisek, P., Vorlicek, J., Sjøl, A., Puska, P., Vartiainen, E., Korhonen, H., Richard, JL, Bingham, A., Cottel, D., Nuttens, MC, Marecaux, N., Dallongeville, J., Salomez, J. L., Montaye, M., Lamamy, N., Houset, M., Pierau, F., Ruidavets, JB, Cambou, JP, Rodier, P., Greiser, E., Herman, B., Nu ̈ssel, E., Osto ̈r Lamm, E., Scheidt, R., Morgenstern, W., Tietze, M., Banos, R., Do ̈ring, A., Muche, J., Schmalfuss, S., Assmann, A., Bo ̈thig, S., Voigt, G., Brasche, S., Quietzsch, D., Gudmundsdo ́ttir, II, Thorsteinsson, T., Sigvaldason H, Giampaoli, S., Righetti, G., De Pasquale, B., Forte, E., Feruglio, GA, Pilotto, L., Cignacco, G., Marini, R., Cesana, GC, Sega, R., BRAMBILLA, PAOLO, Domarkiene, S., Tamosiunas, A., Stewart, A., Kawalec, E., Pazucha, T., Malczewska, M., Rywik, SL, Broda,V, Polakowska, M., Britov, A., Nikitin, Y.u. P, Malyutina, S., Sans, S., Harmsen, P., Rosengren, A., Asplund, K., Huhtasaari, F., Stegmayr, B., Lundberg V, Paccaud, F., Rickenbach, M., Wietlisbach, V., Mainieri, F., McCrum, EE, Cashman, S., Patterson, C., Kerr, M., O’Reilly, D., Scott, A., McConville, M., McMillan, I., McMaster, D, Tunstall Pedoe, H., Smith, WCS, Tavendale, R., Barrett, K., Brown, C., Shewry, M., Hannh, M. K, Jakovljevic, D., Svircevic, A., Mirilov, V., Strasser, V., Mendis, S., Dodu8, S. R. A., Bo ̈thig8, S., Watson, M. J., Hill, M., Kuulasmaa, K., Tuomilehto, J., Rajakangas, A. M., Ma ̈kinen, M., Palonen, L., Cepaitis, Z., Molarius, A., Moltchanov, V., Dobson, A., Fortmann, SP, Epstein, FH, Karvonen, MJ, Prineas, RJ, Williams, OD, Hobbs, M, Jamrozik, K, Thompson, P, Armstrong, B, de Backer, G, De Craene, I, Van Onsem, P, Van Parys, L, De Henauw, S, De Bacquer, D, Kornitzer, M, Berghmans, L, Bara, L, de Smet, P, Jeanjean, M, Brohet, C, Kulbertus, H, Degre, S, Lavenne, F, Jansens, D, Lefebvre, F, Beck, D, Wunsch, G, Bertrand, F, van Houte, M, Rime, B, Rorive, G, Hannot, R, Adrienne, A, Luyckx, A, Wolf, H, Gregor, R, Bata, I, Brownell, B, Webber, K, Skodova ́, Z, Pisa, Z, Berka, L, Cicha, Z, Cerovska ́, J, Emrova ́, R, Hoke, M, Hronkova, M, Pikhartova ́, J, Grafnetter, D, Poledne, R, Vojtisek, P, Vorlicek, J, Wiesner, E, Schroll, M, Kirchhoff, M, Sjøl, A, Quitsau Lund, S, Tuomilehto, J, Puska, P, Vartiainen, E, Korhonen, H, Jousilahti, M, Ducimetie`re, P, Richard, J, Bingham, A, Lang, T, Amouyel, P, Cottel, D, Nuttens, M, Marecaux, N, Dallongeville, J, Salomez, J, Montaye, M, Steclebout, C, Arveiler, D, Schaffer, P, Haas, V, Wagner, A, Lamamy, N, Savouret, M, Houset, M, Pierau, F, Goetz, V, Ferrie`res, J, Ruidavets, J, Cambou, J, Rodier, P, Saulet, C, Greiser, E, Herman, B, Stu ̈demann, G, Nu ̈ssel, E, Osto ̈r Lamm, E, Scheidt, R, Morgenstern, W, Stadler, M, Ganova, M, Keil, U, Tietze, M, Banos, R, Do ̈ring, A, Filipiak, B, Barth, W, Heinemann, L, Muche, J, Schmalfuss, S, Assmann, A, Bo ̈thig, S, Voigt, G, Brasche, S, Quietzsch, D, Classen, E, Sigfu ́sson, N, Gudmundsdo ́ttir, I, Stefa ́nsdo ́ttir, I, Thorsteinsson, T, Sigvaldason, H, Menotti, A, Giampaoli, S, Verdecchia, A, Righetti, G, De Pasquale, B, Di Raimo, P, Forte, E, Majetta, A, Vanuzzo, D, Feruglio, G, Pilotto, L, Cignacco, G, Marini, R, Zilio, G, Cesana, G, Ferrario, M, Sega, R, Mocarelli, P, Brambilla, P, Bluzhas, J, Domarkiene, S, Tamosiunas, A, Reklaitiene, R, Beaglehole, R, Jackson, R, Bonita, R, Stewart, A, Mahon, V, Bingley, W, Pajak, A, Sznajd, J, Kawalec, E, Pazucha, T, Malczewska, M, Mo ́rawska, I, Rywik, S, Broda, V, Polakowska, M, Kurjata, P, Varlamova, A, Britov, A, Konstantinov, V, Timofeeva, V, Alexandri, V, Konstantinova, O, Nikitin, Y, Malyutina, S, Gafarov, V, Feigin, V, Sans, S, Balaguer Vintro ́, V, Balana`, V, Gonzalez, V, Gomez, V, Borras, V, Rode ́s, A, Wilhelmsen, L, Harmsen, P, Rosengren, A, Lappas, G, Asplund, K, Huhtasaari, F, Stegmayr, B, Lundberg, V, Gutzwiller, F, Paccaud, F, Rickenbach, M, Wietlisbach, V, Barazzoni, F, Mainieri, F, Tullen, B, Evans, V, Mccrum, E, Falconer, T, Cashman, S, Patterson, C, Kerr, M, O’Reilly, D, Scott, A, Mcconville, M, Mcmillan, I, Mcmaster, D, Tunstall Pedoe, H, Smith, W, Tavendale, R, Crombie, V, Barrett, K, Brown, C, Shewry, M, Hannh, M, Morrisson, C, Planojevic, M, Jakovljevic, D, Svircevic, A, Mirilov, V, Strasser, V, Mendis, S, Martin8, I, Gyarfas8, V, Pı ́_sa8, V, Dodu8, S, Bo ̈thig8, S, Watson, M, Hill, M, Price, A, Kuulasmaa, K, Ruokokoski, E, Rajakangas, A, Ma ̈kinen, M, Virman Ojanen, T, Palonen, L, Akkila, J, Cepaitis, Z, Molarius, A, Moltchanov, V, Tolonen, H, Dobson, A, Fortmann, S, Shatchkute, A, Zaitsev, V, Epstein, F, Feinleib, M, Karvonen, M, Prineas, R, Williams, O, Hobbs, MST, Jamrozik, K., Thompson, PL, Armstrong, BK, Van Parys, L., Berghmans, L., Kulbertus, HE, Lefebvre, F., Wunsch, G., Bertrand, F., van Houte, M., Rime, B., Hannot, R., Wolf, HK, Gregor, RD, Bata, IR, Brownell, B., Pisa, Z., Berka, L., Cicha, Z., Hronkova, M., Pikhartova ́, J., Grafnetter, D., Poledne, R., Vojtisek, P., Vorlicek, J., Sjøl, A., Puska, P., Vartiainen, E., Korhonen, H., Richard, JL, Bingham, A., Cottel, D., Nuttens, MC, Marecaux, N., Dallongeville, J., Salomez, J. L., Montaye, M., Lamamy, N., Houset, M., Pierau, F., Ruidavets, JB, Cambou, JP, Rodier, P., Greiser, E., Herman, B., Nu ̈ssel, E., Osto ̈r Lamm, E., Scheidt, R., Morgenstern, W., Tietze, M., Banos, R., Do ̈ring, A., Muche, J., Schmalfuss, S., Assmann, A., Bo ̈thig, S., Voigt, G., Brasche, S., Quietzsch, D., Gudmundsdo ́ttir, II, Thorsteinsson, T., Sigvaldason H, Giampaoli, S., Righetti, G., De Pasquale, B., Forte, E., Feruglio, GA, Pilotto, L., Cignacco, G., Marini, R., Cesana, GC, Sega, R., BRAMBILLA, PAOLO, Domarkiene, S., Tamosiunas, A., Stewart, A., Kawalec, E., Pazucha, T., Malczewska, M., Rywik, SL, Broda,V, Polakowska, M., Britov, A., Nikitin, Y.u. P, Malyutina, S., Sans, S., Harmsen, P., Rosengren, A., Asplund, K., Huhtasaari, F., Stegmayr, B., Lundberg V, Paccaud, F., Rickenbach, M., Wietlisbach, V., Mainieri, F., McCrum, EE, Cashman, S., Patterson, C., Kerr, M., O’Reilly, D., Scott, A., McConville, M., McMillan, I., McMaster, D, Tunstall Pedoe, H., Smith, WCS, Tavendale, R., Barrett, K., Brown, C., Shewry, M., Hannh, M. K, Jakovljevic, D., Svircevic, A., Mirilov, V., Strasser, V., Mendis, S., Dodu8, S. R. A., Bo ̈thig8, S., Watson, M. J., Hill, M., Kuulasmaa, K., Tuomilehto, J., Rajakangas, A. M., Ma ̈kinen, M., Palonen, L., Cepaitis, Z., Molarius, A., Moltchanov, V., Dobson, A., Fortmann, SP, Epstein, FH, Karvonen, MJ, Prineas, RJ, and Williams, OD

Abstract

Background and aims: The association between adiposity measures and dyslipidemia has seldom been assessed in a multipopulational setting. Methods and results: 27 populations from Europe, Australia, New Zealand and Canada (WHO MONICA project) using health surveys conducted between 1990 and 1997 in adults aged 35-64 years (n = 40,480). Dyslipidemia was defined as the total/HDL cholesterol ratio >6 (men) and >5 (women).Overall prevalence of dyslipidemia was 25% in men and 23% in women. Logistic regression showed that dyslipidemia was strongly associated with body mass index (BMI) in men and with waist circumference (WC) in women, after adjusting for region, age and smoking. Among normal-weight men and women (BMI<25 kg/m2), an increase in the odds for being dyslipidemic was observed between lowest and highest WC quartiles (OR = 3.6, p < 0.001). Among obese men (BMI ≥ 30), the corresponding increase was smaller (OR = 1.2, p = 0.036). A similar weakening was observed among women. Classification tree analysis was performed to assign subjects into classes of risk for dyslipidemia. BMI thresholds (25.4 and 29.2 kg/m2) in men and WC thresholds (81.7 and 92.6 cm) in women came out at first stages. High WC (>84.8 cm) in normal-weight men, menopause in women and regular smoking further defined subgroups at increased risk. Conclusion: standard categories of BMI and WC, or their combinations, do not lead to optimal risk stratification for dyslipidemia in middle-age adults. Sex-specific adaptations are necessary, in particular by taking into account abdominal obesity in normal-weight men, post-menopausal age in women and regular smoking in both sexes

Published
2013

5. Seasonal variation in the incidence of Type 1 diabetes mellitus during 1983 to 1992 in the countries around the Baltic Sea.

Author

Padaiga, Z, Tuomilehto, J, Karvonen, M, Dahlquist, Gisela, Podar, T, Adojaan, B, Urbonaite, B, Zalinkevicius, R, Brigis, G, Virtala, E, Kohtamäki, K, Cepaitis, Z, Tuomilehto-Wolf, E, Padaiga, Z, Tuomilehto, J, Karvonen, M, Dahlquist, Gisela, Podar, T, Adojaan, B, Urbonaite, B, Zalinkevicius, R, Brigis, G, Virtala, E, Kohtamäki, K, Cepaitis, Z, and Tuomilehto-Wolf, E

Abstract

The seasonal pattern with two cycles among older children and one cycle only among younger children may indicate different triggers of Type 1 diabetes mellitus for different age groups.

Published
1999

7. Seasonal variation in the incidence of Type 1 diabetes mellitus during 1983 to 1992 in the countries around the Baltic Sea

Author

Padaiga, Z., primary, Tuomilehto, J., additional, Karvonen, M., additional, Dahlquist, G., additional, Podar, T., additional, Adojaan, B., additional, Urbonaite, B., additional, Zalinkevicius, R., additional, Brigis, G., additional, Virtala, E., additional, Kohtamaki, K., additional, Cepaitis, Z., additional, and Tuomilehto-Wolf, E., additional

Published
1999
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10. Comparison of the Incidence of Insulin-Dependent Diabetes Mellitus in Childhood among Five Baltic Populations during 1983–1988

Author

TUOMILEHTO, J, primary, PODAR, T, additional, BRIGIS, G, additional, URBONAITE, B, additional, REWERS, M, additional, ADOJAAN, B, additional, CEPAITIS, Z, additional, KALITS, I, additional, KING, H, additional, LaPORTE, R, additional, LOUNAMAA, R, additional, PADAIGA, Z, additional, REUNANEN, A, additional, TUOMILEHTO-WOLF, E, additional, and WALCZAK, M, additional

Published
1992
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11. Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study.

Author

Laaksonen DE, Lindström J, Lakka TA, Eriksson JG, Niskanen L, Wikström K, Aunola S, Keinänen-Kiukaanniemi S, Laakso M, Valle TT, Ilanne-Parikka P, Louheranta A, Hämäläinen H, Rastas M, Salminen V, Cepaitis Z, Hakumäki M, Kaikkonen H, Härkönen P, and Sundvall J

Abstract

Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals. [ABSTRACT FROM AUTHOR]

Published
2005
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14. Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations.

Author

Tunstall-Pedoe H, Vanuzzo D, Hobbs M, Mähönen M, Cepaitis Z, Kuulsamaa K, Keill U, WHO MONICA Project, Tunstall-Pedoe, H, Vanuzzo, D, Hobbs, M, Mähönen, M, Cepaitis, Z, Kuulasmaa, K, and Keil, U

Abstract

Background: The revolution in coronary care in the mid-1980s to mid-1990s corresponded with monitoring of coronary heart disease (CHD) in 31 populations of the WHO MONICA Project. We studied the impact of this revolution on coronary endpoints.Methods: Case fatality, coronary-event rates, and CHD mortality were monitored in men and women aged 35-64 years in two separate 3-4-year periods. In each period, we recorded percentage use of eight treatments: coronary-artery reperfusion before, thrombolytics during, and beta-blockers, antiplatelet drugs, and angiotensin-converting-enzyme (ACE) inhibitors before and during non-fatal myocardial infarction. Values were averaged to produce treatment scores. We correlated changes across populations, and regressed changes in coronary endpoints on changes in treatment scores.Findings: Treatment changes correlated positively with each other but inversely with change in coronary endpoints. By regression, for the common average treatment change of 20, case fatality fell by 19% (95% CI 12-26) in men and 16% (5-27) in women; coronary-event rates fell by 25% (16-35) and 23% (7-39); and CHD mortality rates fell by 42% (31-53) and 34% (17-50). The regression model explained an estimated 61% and 41% of variance for men and women in trends for case fatality, 52% and 30% for coronary-event rates, and 72% and 56% for CHD mortality.Interpretation: Changes in coronary care and secondary prevention were strongly linked with declining coronary endpoints. Scores and benefits followed a geographical east-to-west gradient. The apparent effects of the treatment might be exaggerated by other changes in economically successful populations, so their specificity needs further assessment. [ABSTRACT FROM AUTHOR]

Published
2000
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15. New susceptibility haplotype for type 1 diabetes. DIME Study Group.

Author

Tuomilehto-Wolf, E, Tuomilehto, J, Cepaitis, Z, and Lounamaa, R

Subjects
*COMPARATIVE studies, *GENES, *TYPE 1 diabetes, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *PUBLIC health surveillance, *RESEARCH, *HLA-B27 antigen, *EVALUATION research, *HAPLOTYPES
Abstract

In a prospective family study in Finland HLA genotyping was carried out for 1610 individuals from 422 consecutively registered families of children aged 14 years or younger with newly diagnosed insulin-dependent diabetes mellitus (IDDM). A haplotype (A2, Cw1, Bw56, w6, DR4) that has not been identified previously was the third most common (5.5%) among 746 haplotypes found in the probands. Only the haplotypes A1, Cw7, B8, w6, DR3 and A2, Cw3, Bw62, w6, DR4, which are well known to occur with high frequency in IDDM, were more frequent (10.7% and 9.7%, respectively). Among the 30 families in which a parent had IDDM, the newly identified haplotype was the most common haplotype transmitted from the diabetic parent to the proband (16.7%). Among 642 "non-diabetic" haplotypes (parental haplotypes not found in probands, or siblings or parents with IDDM), this haplotype was found only twice. This haplotype may partially explain the high incidence of IDDM in Finland. [ABSTRACT FROM AUTHOR]

Published
1989
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16. Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial.

Author

Lindström J, Eriksson JG, Valle TT, Aunola S, Cepaitis Z, Hakumäki M, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Martikkala V, Moltchanov V, Rastas M, Salminen V, Sundvall J, Uusitupa M, and Tuomilehto J

Subjects
Adult, Confidence Intervals, Diabetes Mellitus, Type 2 therapy, Female, Finland, Follow-Up Studies, Glucose Tolerance Test, Humans, Male, Middle Aged, Reference Values, Risk Assessment, Severity of Illness Index, Treatment Outcome, Diabetes Mellitus, Type 2 prevention & control, Diet, Life Style, Primary Prevention methods, Weight Loss
Abstract

Type 2 diabetes mellitus is increasing worldwide largely as a result from increasing obesity and sedentary lifestyle. The Finnish Diabetes Prevention Study (DPS) is the first individually randomized controlled clinical trial to test the feasibility and efficacy of lifestyle modification in high-risk subjects. We randomly assigned 522 (172 men, 350 women) middle-aged (mean age 55 yr), overweight (mean body mass index 31 kg/m(2)) subjects with impaired glucose tolerance either to the lifestyle intervention or control group. Each subject in the intervention group received individualized counseling aimed at reducing weight and intake of total and saturated fat, and increasing intake of fiber and physical activity. An oral glucose tolerance test was performed annually to detect incident cases of diabetes and to measure changes in metabolic parameters. The mean (+/- SD) weight reduction from baseline to year 1 and to year 2, respectively, was 4.2 +/- 5.1 kg and 3.5 +/- 5.5 in the intervention group and 0.8 +/- 3.7 kg and 0.8 +/- 4.4 in the control group (P < 0.001 between the groups). At the time of first analysis of the outcome data the mean duration of follow-up was 3.2 yr. The risk of diabetes was reduced by 58% (P < 0.001) in the intervention group compared with the control group. The reduction in the incidence of diabetes was directly associated with number and magnitude of lifestyle changes made. In conclusion, the DPS is the first controlled trial demonstrating that type 2 diabetes can be prevented by changes in lifestyle in high-risk subjects.

Published
2003
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17. Comparison of trends in ischaemic heart disease between North Karelia, Finland, and Kaunas, Lithuania, from 1971 to 1987.

Author

Rastenyte D, Salomaa V, Mustaniemi H, Rasteniene D, Grazuleviciene R, Cepaitis Z, Kankaanpää J, Kuulasmaa K, Torppa J, and Bluzhas J

Subjects
Adult, Female, Finland epidemiology, Humans, Incidence, Lithuania epidemiology, Male, Middle Aged, Myocardial Infarction epidemiology, Myocardial Ischemia mortality, Sex Factors, Myocardial Ischemia epidemiology
Abstract

Objective: To compare the long-term trends in mortality and attack rate of ischaemic heart disease in North Karelia, Finland, and in Kaunas, Lithuania, from 1971 to 1987., Design: Data on routine mortality statistics were obtained from the Central Statistical Office of Finland and from the Central City Archives of Kaunas. In addition, data from the community based myocardial infarction registers were used. The registers used similar diagnostic criteria and had operated in both areas during the entire study period., Setting: The province of North Karelia in Finland and the city of Kaunas in Lithuania., Subjects: The target populations were the people of North Karelia and Kaunas aged 35-64 years., Main Outcome Measures: Mortality from ischaemic heart disease and the attack rate of acute myocardial infarction., Results: In North Karelia mortality from ischaemic heart disease and the attack rate of acute myocardial infarction declined steeply both in men and women. This decline was accompanied by a decrease in total mortality. In Kaunas, both mortality and the attack rate increased in men but remained unchanged in women. In 1985 to 1987, age standardised total mortality per 100,000 inhabitants was similar in the two populations in men (1081 (95% confidence interval (CI) 1013 to 1149), in North Karelia; 1082 (95% CI 1032 to 1132), in Kaunas). The proportional mortality from ischaemic heart disease was considerably higher in North Karelia (40%) than in Kaunas (28%). In women, age standardised total mortality was lower in North Karelia (350 (95% CI 312-388)) than in Kaunas (440 (95% CI 413 to 467)). The proportional mortality from ischaemic heart disease in women was also higher in North Karelia (28%) than in Kaunas (13%)., Conclusions: Despite the remarkable decline in the occurrence of ischaemic heart disease, it still remains the most important cause of premature mortality in North Karelia. In Kaunas ischaemic heart disease mortality and attack rate increased in men. Experiences from successful cardiovascular disease prevention programmes in western countries, such as the North Karelia Project, should be exploited to prevent an increasing epidemic of ischaemic heart disease in eastern Europe.

Published
1992
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