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1. Statin use moderates the beneficial effects of aerobic exercise on older adults' performances on the Stroop test: A subanalysis

Author

Kathia Saillant, Francis Langlois, Martin Juneau, Thien Tuong Minh Vu, Louis Bherer, Kristell Pothier, Navin Kaushal, Antoine Langeard, Anil Nigam, Mobilités : Vieillissement, Pathologie, Santé (COMETE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Sherbrooke (UdeS), Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Centre de recherche de l'Institut universitaire de gériatrie de Montreal (CRIUGM), and Université de Montréal (UdeM)

Subjects
0301 basic medicine, Aging, medicine.medical_specialty, Statin, medicine.drug_class, Physical exercise, Biochemistry, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, Endocrinology, Cognition, Genetics, Medicine, Aerobic exercise, Humans, Molecular Biology, Exercise, ComputingMilieux_MISCELLANEOUS, Aged, Hand Strength, business.industry, Confounding, Cardiorespiratory fitness, Cell Biology, Moderation, 030104 developmental biology, Stroop Test, Physical therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, 030217 neurology & neurosurgery, Stroop effect
Abstract

Aerobic training can lead to improved cognition in older adults and this effect can be explained by enhanced cardiorespiratory fitness. However, statins could limit the physical benefits of aerobic training by altering the mechanisms through which exercise improves cognition. Whether statins could have an effect on the cognitive benefits associated with aerobic training remains to be elucidated. The objective of this study was to determine whether the cognitive benefits of aerobic training were comparable in statin users and non-users. A total of 144 sedentary participants (60 y.o.; 106 non-users, 38 statin users) were included. Participants were either part of an aerobic training group (n = 75) or a control group (n = 69). Cognition was assessed using the Stroop test. Analyses were performed on z-score changes from pre to post-intervention of Stroop reaction time (RT) and number of errors, using Two-factor ANCOVAs, while controlling for potential confounding factors (age, education, BMI, Charlson Comorbidity Index, sex, protocol and handgrip strength). The moderating effect of statins on the cognitive changes associated with aerobic training was determined through moderation analyses. An interaction effect on the Stroop switching condition was detected between intervention and statin intake (F [1, 140] = 5.659, P 0.01). The intervention effect on switching RT was moderated by statin intake, where intervention improved switching RT only in non-users (Effect = 0.1678; P 0.01). Statins could limit the cognitive benefits of aerobic training on switching capacities in some patients. Future randomized studies including a larger number of participants and looking at different types of statins should be conducted to confirm these results.

Published
2021

2. A comparison of physical exercise and cognitive training interventions to improve determinants of functional mobility in healthy older adults

Author

Anil Nigam, Tudor Vrinceanu, Laurent Bosquet, Kristell Pothier, Brittany Intzandt, Karen Z. H. Li, Maxime Lussier, Nicolas Berryman, Louis Bherer, T. T. Minh Vu, Antony D. Karelis, Psychologie des âges de la vie et adaptation (PAVeA), Université de Tours (UT), Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), Université de Poitiers, Centre de recherche de l'Institut universitaire de gériatrie de Montreal (CRIUGM), Université de Montréal (UdeM), Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Department of Sport Studies, Bishop’s University, Québec, Bishop’s University [Sherbrooke, Canada], and Université de Tours

Subjects
0301 basic medicine, Aging, medicine.medical_specialty, Gross motor skill, Psychological intervention, Physical exercise, Timed Up and Go test, Walking, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Physical medicine and rehabilitation, Cognition, Genetics, Medicine, Aerobic exercise, Humans, Molecular Biology, Exercise, ComputingMilieux_MISCELLANEOUS, Aged, business.industry, Cardiorespiratory fitness, Cell Biology, Cognitive training, Exercise Therapy, Walking Speed, 030104 developmental biology, [SCCO.PSYC]Cognitive science/Psychology, business, 030217 neurology & neurosurgery
Abstract

Objectives Mobility is a complex but crucial clinical outcome in older adults. Past observational studies have highlighted that cardiorespiratory fitness (CRF), energy cost of walking (ECW), and cognitive switching abilities are associated with mobility performance, making these key determinants of mobility intervention targets to enhance mobility in older adults. The objective of this study was to compare, in the same design, the impact of three training methods - each known to improve either CRF, ECW, or cognitive switching abilities - on mobility in healthy older adults. Methods Seventy-eight participants (69.28 ± 4.85yo) were randomly assigned to one of three twelve-week interventions: Aerobic Exercise (AE; n = 26), Gross Motor Abilities (GMA; n = 27), or Cognitive (COG; n = 25) training. Each intervention was designed to improve one of the three key determinants of mobility (CRF, ECW, and cognitive switching). Primary outcomes (usual gait speed, and TUG performance) and the three mobility determinants were measured before and after the intervention. Results Repeated-measures ANOVAs showed a time effect for TUG performance (F(1,75) = 14.92, p Discussion This study provides further support to the notion that multiple interventional approaches (aerobic, gross motor exercise, or cognitive training) can be employed to improve functional mobility in older adults, giving them, and professionals, more options to promote healthy ageing.

Published
2020

3. Sex-moderated association between body composition and cognition in older adults

Author

Kristell, Pothier, Pothier, Kristell, Vrinceanu, Tudor, Intzandt, Brittany, Karelis, Antony, Lussier, Maxime, Vu, T.T. Minh, Nigam, Anil, Li, Karen Z.H., Berryman, Nicolas, Bherer, Louis, Loggia, Gilles, Attoh-Mensah, Elpidio, Morello, Rémy, Lescure, Pascale, Bocca, Marie-Laure, Marcelli, Christian, CHAVOIX, Chantal, Vu, TT Minh, Li, Karen, Gauthier, Claudine, Langeard, Antoine, Fakrahnak, Zahra, Noriega de la Colina, Adrián, Vu, Thien Tuong Minh, Girouard, Hélène, Maltais, Mathieu, de Souto Barreto, Philipe, Cantet, Christelle, Andrieu, Sandrine, Rolland, Yves, Vellas, Bruno, Mobilités : Attention, Orientation et Chronobiologie (COMETE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Psychologie des âges de la vie et adaptation (PAVeA), Université de Tours, Department of Sport Studies, Bishop’s University, Québec, Bishop’s University [Sherbrooke, Canada], Centre de recherche de l'Institut universitaire de gériatrie de Montreal (CRIUGM), Université de Montréal (UdeM), Université de Tours (UT), Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Département Filière Gériatrique [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Rhumatologie [CHU Caen], Centre National de la Recherche Scientifique (CNRS), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Fédérale Toulouse Midi-Pyrénées

Subjects
Male, 0301 basic medicine, Gerontology, Aging, Biochemistry, Body Mass Index, 03 medical and health sciences, Absorptiometry, Photon, Cognition, 0302 clinical medicine, Endocrinology, Genetics, Humans, Medicine, Longitudinal Studies, Cognitive decline, Association (psychology), Molecular Biology, ComputingMilieux_MISCELLANEOUS, Aged, 2. Zero hunger, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Montreal Cognitive Assessment, Cell Biology, Moderation, Trunk, 030104 developmental biology, [SCCO.PSYC]Cognitive science/Psychology, Body Composition, Lean body mass, Female, business, Body mass index, 030217 neurology & neurosurgery
Abstract

Background Some studies have reported an association between body composition and cognition in older adults, but underlying mechanisms and physiological factors remain poorly understood. Moreover, sex-related differences in metabolic health and age-related cognitive decline have gained major interest lately. The present study investigated the potential moderating effect of sex on the relationship between body composition and cognition in older adults. Methods Global cognition, assessed by the Montreal Cognitive Assessment (MoCA), and body composition, measured using dual-energy x-ray absorptiometry (DXA), were analyzed in 155 women and 65 men aged 60 years old or more. Moderation analyses were computed to determine if sex moderates the effect of the different body composition parameters on the MoCA while controlling for the body mass index and the level of education of the participants. Results Sex moderated the association between total lean mass, trunk lean mass, arms lean mass, and the MoCA score. These body composition parameters were positively associated with cognition only in men. Fat mass was not associated with cognition in any sex. Conclusion Overall, higher lean mass and in particular trunk and arms lean mass was associated with higher cognitive abilities in older men. Longitudinal studies or intervention studies are needed to further identify physiological mechanisms that sustain the relationship between lean mass and cognition.

Published
2020

4. Systolic Blood Pressure And Heart Rate Recovery Are Related To Cognition In Healthy Older Adults

Author

Intzandt, Brittany, Vrinceanu, Tudor, Kristell, Pothier, Nigam, Anil, Vu, TT Minh, Li, Karen, Berryman, Nicolas, Gauthier, Claudine, Bherer, Louis, Psychologie des âges de la vie et adaptation (PAVeA), Université de Tours (UT), Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Department of Sport Studies, Bishop’s University, Québec, Bishop’s University [Sherbrooke, Canada], Centre National de la Recherche Scientifique (CNRS), Centre de recherche de l'Institut universitaire de gériatrie de Montreal (CRIUGM), Université de Montréal (UdeM), and Université de Tours

Subjects
[SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.PSYC]Cognitive science/Psychology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

5. Barriers to physical activity in coronary artery disease patients: Development and validation of a new scale

Author

Martin Juneau, Vincent Gremeaux, Charles Joussain, Davy Laroche, B. D’antono, J. Joubert, Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées ( END-ICAP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Pôle Rééducation - Réadaptation (Médecine Physique et Réadaptation) (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie ( CIC-P803 ), Université de Bourgogne ( UB ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département de Psychologie [Montréal], Université de Montréal [Montréal], Research Center, Montreal Heart Institute, Université de Montréal ( UdeM ), Department of Medicine, Montreal, Université de Montréal, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal, Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montréal (UdeM), and Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal

Subjects
Adult, Male, medicine.medical_specialty, Psychometrics, Neuropsychological Tests, 030204 cardiovascular system & hematology, Coronary artery disease, Statistics, Nonparametric, Validity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cronbach's alpha, medicine, Content validity, Humans, Orthopedics and Sports Medicine, Prospective cohort study, Exercise, Reliability (statistics), Face validity, Principal Component Analysis, Physical activity, Questionnaire, business.industry, Rehabilitation, Reproducibility of Results, Construct validity, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Reliability, Scale (social sciences), Physical therapy, Anxiety, Female, Self Report, medicine.symptom, business, Barriers, 030217 neurology & neurosurgery
Abstract

Objective To develop and validate a self-report questionnaire to measure barriers to regular physical activity (PA) in patients with stable coronary artery disease (CAD). Methods Phase 1: 17 patients completed a semi-structured interview. After grouping and reformulating the reported barriers, their pertinence was reevaluated by the patients. Then, a decision algorithm was used to select items. A principal component analysis was performed to determine content validity. Phase 2: 49 patients completed the questionnaire resulting from phase 1 twice, 7 days apart, and questionnaires to evaluate depression, anxiety, and the level of physical activity. Construct validity was evaluated by analysis of Spearman's correlation coefficient between the total score for the questionnaire and a convergent dimension (anxiety), as well as a divergent dimension (Dijon physical activity score). Internal consistency was evaluated by Cronbach's alpha coefficient. Test-retest reliability was evaluated by the intraclass coefficient (ICC). Results Eleven items were selected after phase 1. The questionnaire presented good face validity and the content validity seemed satisfactory after analysis of the literature by the experts. Construct validity was moderate. Internal consistency was very good (Cronbach's α>0.81). Reproducibility was excellent with an ICC at 0.95. Feasibility was good with less than 3 minutes to complete the questionnaire. Conclusion This questionnaire presents good psychometric properties. A further prospective study should evaluate sensitivity to change and help determine a threshold value indicating the need for a specific behavioral strategy to alleviate barriers to physical activity in these patients.

Published
2017

6. High-intensity interval training vs. hydrochlorothiazide on blood pressure, cardiovascular health and cognition: Protocol of a non-inferiority trial

Author

Miloudza Olmand, Florent Besnier, Kathia Saillant, Annick Fortier, Martine Lacroix, Daniel Gagnon, Louis Bherer, Simon-Olivier Cloutier, Catherine-Alexandra Grégoire, Julie Lalongé, Mathieu Gayda, Antoine Langeard, Christine Gagnon, Anil Nigam, Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Université de Montréal (UdeM), Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal Health Innovations Coordinating Center [Montreal Heart Institute] (MHICC), Montreal Heart Institute - Institut de Cardiologie de Montréal, and CRSN/Faculté de médecine Université de Montréal

Subjects
medicine.medical_specialty, [SDV]Life Sciences [q-bio], Equivalence Trials as Topic, Prehypertension, Interval training, law.invention, 03 medical and health sciences, Cognition, 0302 clinical medicine, Hydrochlorothiazide, Randomized controlled trial, law, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Diuretics, Exercise, Antihypertensive Agents, Aged, 030505 public health, business.industry, Cardiovascular outcome, General Medicine, medicine.disease, 3. Good health, Treatment Outcome, Blood pressure, Hypertension, High-intensity interval training, Ambulatory, Arterial stiffness, Physical therapy, Drug Therapy, Combination, 0305 other medical science, business, medicine.drug
Abstract

Background While the number of people with hypertension (HBP) continues to increase, the therapeutic target for optimal blood pressure (BP) has been revised to a lower level. Studies have suggested that High-Intensity Interval Training (HIIT) could be as efficient as BP-lowering drugs, but no study has compared their efficacy in a randomized trial. The aim of this protocol is to determine if HIIT is as efficient as Hydrochlorothiazide (HCTZ) in lowering 24 h ambulatory BP in prehypertensive older adults. Moreover, the secondary aim is to determine if HIIT is associated with greater cardiovascular and cognitive benefits than HCTZ. Methods This study is an interventional, single-center, non-inferiority trial, with two randomized parallel groups of prehypertensive participants aged 60 years or more. One group will be prescribed daily doses of 12.5 mg of HCTZ for 12 weeks, and the other group will follow thrice-weekly HIIT for 12 weeks. Each group will be composed of 30 participants. The primary outcome is 24 h ambulatory BP. Secondary outcomes are scores on neuropsychological assessments, balance and gait performances, maximal oxygen uptake, peripheral endothelial function, and arterial stiffness. Non-inferiority tests will be performed on the primary outcome, and secondary outcomes will be compared using independent t-tests. Conclusion This study will determine if HIIT is at least as efficient as HCTZ in lowering BP in prehypertensive older adults. This study will also determine if HIIT provides greater benefits in terms of cardiovascular and cognitive status ( NCT04103411 ).

Published
2021

7. Cognitive function in patients with stable coronary heart disease: Related cerebrovascular and cardiovascular responses

Author

Vincent Gremeaux, Véronique Labelle, Martin Juneau, Annik Fortier, Gabriel Lapierre, Joffrey Drigny, Anil Nigam, Olivier Dupuy, Mathieu Gayda, Louis Bherer, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal, Montreal Heart Institute - Institut de Cardiologie de Montréal, Department of Medicine, Montreal, Université de Montréal, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), PERFORM centre, Concordia University [Montreal, Canada], Centre de recherche de l'Institut universitaire de gériatrie de Montreal ( CRIUGM ), Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) ( MOVE ), Université de Poitiers, Montreal Health Innovations Coordinating Center [Montreal Heart Institute] ( MHICC ), Cardiovascular Prevention and Rehabilitation Centre Foundation Montreal Heart Institute Foundation Reseau Quebecois de Recherche sur le Vieillissement, Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Concordia University [Montreal], Centre de recherche de l'Institut universitaire de gériatrie de Montreal (CRIUGM), Université de Montréal (UdeM), Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), and Montreal Health Innovations Coordinating Center [Montreal Heart Institute] (MHICC)

Subjects
Male, Aging, cardiac-output, Cardiac index, Hemodynamics, lcsh:Medicine, Coronary Disease, 030204 cardiovascular system & hematology, Neuropsychological Tests, Cardiovascular System, Vascular Medicine, 0302 clinical medicine, Cognition, Spectrum Analysis Techniques, Learning and Memory, Medicine and Health Sciences, Coronary Heart Disease, Public and Occupational Health, Prospective Studies, older-adults, lcsh:Science, Cognitive Impairment, Brain Mapping, Multidisciplinary, Spectroscopy, Near-Infrared, cardiorespiratory fitness, medicine.diagnostic_test, exercise, Cognitive Neurology, near-Infrared Spectroscopy, Hematology, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Sports Science, failure, Impedance cardiography, Cognitive inhibition, Neurology, Cerebrovascular Circulation, Cardiology, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, impedance cardiograph device, performance, Research Article, Adult, medicine.medical_specialty, Cognitive Neuroscience, Prefrontal Cortex, Infrared Spectroscopy, Research and Analysis Methods, Asymptomatic, Cardiography, Impedance, artery-disease, metabolic syndrome, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Memory, Internal medicine, medicine, Humans, cerebral oxygenation, Sports and Exercise Medicine, Aged, Long-Term Memory, Working memory, business.industry, Pulmonary Gas Exchange, lcsh:R, Biology and Life Sciences, Physical Activity, Surgery, Oxygen, Physical Fitness, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Exercise Test, Cognitive Science, lcsh:Q, Verbal memory, business, Mental Status Schedule, 030217 neurology & neurosurgery, Neuroscience
Abstract

Chronic exercise has been shown to prevent or slow age-related decline in cognitive functions in otherwise healthy, asymptomatic individuals. We sought to assess cognitive function in a stable coronary heart disease (CHD) sample and its relationship to cerebral oxygenation-perfusion, cardiac hemodynamic responses, and [Formula: see text] peak compared to age-matched and young healthy control subjects. Twenty-two young healthy controls (YHC), 20 age-matched old healthy controls (OHC) and 25 patients with stable CHD were recruited. Cognitive function assessment included short term-working memory, perceptual abilities, processing speed, cognitive inhibition and flexibility and long-term verbal memory. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamic (impedance cardiography) and left frontal cerebral oxygenation-perfusion (near-infra red spectroscopy) were measured during and after a maximal incremental ergocycle test. Compared to OHC and CHD, YHC had higher [Formula: see text] peak, maximal cardiac index (CI max), cerebral oxygenation-perfusion (ΔO2 Hb, ΔtHb: exercise and recovery) and cognitive function (for all items) (P

Published
2017

8. Cardiovascular and cerebral hemodynamics during exercise and recovery in obese individuals as a function of their fitness status

Author

Louis Bherer, Olivier Dupuy, Sarah Fraser, Vincent Gremeaux, Martin Juneau, Mathieu Gayda, Anil Nigam, Gabriel Lapierre, Faculté de Médecine, Université de Montréal, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal, Montreal Heart Institute - Institut de Cardiologie de Montréal, Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) ( MOVE ), Université de Poitiers, Interdisciplinary School of Health Sciences (University of Ottawa, Canada), University of Ottawa [Ottawa], Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] ( PIT ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie ( CIC-P803 ), Université de Bourgogne ( UB ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Montreal Heart Institute Foundation EPIC Centre Foundation Reseau Quebecois de Recherche sur le Vieillissement Diabete Quebec, Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] (PIT), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), and Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Central Nervous System, Male, Cardiac output, obesity, intensity interval exercise, Physiology, near-infrared spectroscopy, cardiac-output, Cardiac index, Gas Exchange and Transport, Blood Pressure, 030204 cardiovascular system & hematology, Cardiovascular Physiology, Incremental exercise, Hemoglobins, 0302 clinical medicine, Original Research, medicine.diagnostic_test, exercise, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Endurance and Performance, Middle Aged, Exercise Therapy, Impedance cardiography, Cardiorespiratory Fitness, Cerebrovascular Circulation, Cardiology, Female, oxygenation, impedance cardiograph device, Adipose Tissue and Obesity, Cardiac function curve, medicine.medical_specialty, men, metabolic syndrome, normal-weight, 03 medical and health sciences, recovery, Oxygen Consumption, Physiology (medical), Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Aerobic exercise, Humans, Aged, Cardiac and cerebral hemodynamics, business.industry, Oxygenation, Blood pressure, Vasoconstriction, Physical therapy, diastolic dysfunction, business, coronary-heart-disease, 030217 neurology & neurosurgery
Abstract

International audience; The aim of this study was to compare cardiovascular hemodynamics and cerebral oxygenation/perfusion (COP) during and after maximal incremental exercise in obese individuals according to their aerobic fitness versus age-matched healthy controls (AMHC). Fifty-four middle-aged obese (OB) and 16 AMHC were recruited. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamics (impedance cardiography), and left frontal COP (near-infrared spectroscopy: NIRS) were measured continuously during a maximal incremental ergocycle test. During recovery, reoxygenation/perfusion rate (ROPR: oxyhemoglobin: Delta O(2)Hb, deoxyhemoglobin: Delta HHb and total hemoglobin: Delta tHb; with NIRS) was also measured. Obese participants (OB, n = 54) were divided into two groups according to the median VO2 peak: the low-fit obese (LF-OB, n = 27) and the high-fit obese (HF-OB, n = 27). During exercise, end tidal pressure of CO2 (PETCO2), and COP (Delta O(2)Hb, Delta HHb and Delta tHb) did not differ between groups (OB, LF-OB, HF-OB, AMHC). During recovery, PETCO2 and ROPR (Delta O(2)Hb, Delta HHb and DtHb) were similar between the groups (OB, LF-OB, HF-OB, AMHC). During exercise and recovery, cardiac index was lower (P < 0.05) in LF-OB versus the other two groups (HF-OB, AMHC). As well, systolic blood pressure was higher during exercise in the OB, LF-OB and HF-OB groups versus AMHC (P < 0.05). When compared to AMHC, obese individuals (OB, LF-OB, HF-OB) have a similar cerebral vasoreactivity by CO2 and cerebral hemodynamics during exercise and recovery, but a higher systolic blood pressure during exercise. Higher fitness in obese subjects (HF-OB) seems to preserve their cardiopulmonary and cardiac function during exercise and recovery.

Published
2017

9. The ambulatory hypotensive effect of aerobic training: a reappraisal through a meta-analysis of selected moderators

Author

Laurent Bosquet, Vincent Gremeaux, Denis Arvisais, Thibaut Guiraud, Daniel Herpin, Philippe Sosner, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Service de cardiologie [CHU de Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre médico-sportif Mon Stade [Paris], Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), Université de Poitiers, Réeducation Cardio-Vasculaire et Pulmonaire [Clinique de Saint-Orens], Clinique Saint-Orens, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Pôle Rééducation - Réadaptation (Médecine Physique et Réadaptation) (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] (PIT), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Direction of Libraries / Direction des bibliothèques [Montréal], Université de Montréal (UdeM), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers - Faculté des Sciences du sport, Département de Kinésiologie, Laboratoire d'Étude de la Santé Cognitive des Ainés [Montréal] (LESCA), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal, CHU de Poitiers, Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) ( MOVE ), Institut des Maladies Métaboliques et Cardiovasculaires ( I2MC ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Hôpital de Rangueil-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] ( PIT ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie ( CIC-P803 ), Université de Bourgogne ( UB ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Montréal [Montréal], Faculté de Médecine et de Pharmacie - Université de Poitiers, Faculté des Sciences du sport - Université de Poitiers, Université de Montréal, LESCA, and LESCA - Université du Québec à Montréal

Subjects
medicine.medical_specialty, Diastole, Blood Pressure, Physical Therapy, Sports Therapy and Rehabilitation, 030204 cardiovascular system & hematology, Prehypertension, Weighted mean difference, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Weight loss, Weight Loss, medicine, Humans, Aerobic exercise, Orthopedics and Sports Medicine, pre-hypertension, 030212 general & internal medicine, 10. No inequality, Exercise, training, business.industry, Age Factors, Blood Pressure Determination, Blood Pressure Monitoring, Ambulatory, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diet, Exercise Therapy, hypotensive, Blood pressure, Meta-analysis, Ambulatory, Hypertension, Physical therapy, medicine.symptom, business
Abstract

International audience; The effectiveness of regular exercise in decreasing both systolic and diastolic blood pressure (BP) is well-established. Our purpose was to assess the impact of both subject and physical activity program characteristics on ambulatory BP through a meta-analysis of the existing literature. Three databases (PubMed, Embase, Web of Science) were searched using relevant terms and strategies. From 637 identified records, 37 studies met inclusion criteria: details about training intervention and participant characteristics, pre- and post-training ambulatory BP measurements, at home (HBPM) or during 24-h (ABPM). The weighted mean difference was for 24-h systolic/diastolic ABPM (n = 847 participants): -4.06/-2.77 mmHg (95%CI: -5.19 to -2.93/-3.58 to -1.97; P < 0.001), for daytime (ABPM or HBPM, n = 983): -3.78/-2.73 mmHg (95%CI: -5.09 to -2.47/-3.57 to -1.89; P < 0.001) and nighttime ABPM periods (n = 796): -2.35/-1.70 mmHg (95%CI: -3.26 to -1.44/-2.45 to -0.95; P < 0.001). Characteristics significantly influencing BP improvement were: an initial office BP ≥130/85 mmHg and diet-induced weight-loss. We found no differences according to sex, age, or training characteristics (intensity, number of sessions, training duration). Antihypertensive effects of aerobic training assessed by ambulatory BP measurements appear significant and clinically relevant for both daytime and nighttime periods, in particular for participants with an office BP ≥130/85 mmHg.

Published
2017

10. Ambulatory blood pressure reduction following high-intensity interval exercise performed in water or dryland condition

Author

Vincent Gremeaux, Christopher Lemasson, Julie Lalongé, Philippe Sosner, D. Hayami, Laurent Bosquet, Martin Juneau, Mauricio Garzon, Olivier Dupuy, Mathieu Gayda, Mariel Gonzales, Anil Nigam, Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) ( MOVE ), Université de Poitiers, Centre médico-sportif Mon Stade [Paris], Service de cardiologie [CHU de Poitiers], CHU de Poitiers, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal, Montreal Heart Institute - Institut de Cardiologie de Montréal, Department of Medicine, Montreal, Université de Montréal, université de montréal kinésiologie, Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] ( PIT ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie ( CIC-P803 ), Université de Bourgogne ( UB ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Pôle Rééducation - Réadaptation (Médecine Physique et Réadaptation) (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] (PIT), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)

Subjects
Male, Hemodynamics, Blood Pressure, 030204 cardiovascular system & hematology, High-Intensity Interval Training, Random Allocation, 0302 clinical medicine, prevention, Immersion, guidelines, physical-activity, Pulse wave velocity, high-intensity interval exercise, mechanisms, High intensity, Blood Pressure Monitoring, Ambulatory, Middle Aged, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, arterial stiffness, pulse-wave velocity, Hypertension, Practice Guidelines as Topic, Cardiology, Female, Ambulatory blood pressure monitoring, Cardiology and Cardiovascular Medicine, High-intensity interval training, management, hypertensive patients, medicine.medical_specialty, Ambulatory blood pressure, Diastole, men, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, water exercise, Internal Medicine, medicine, Humans, Exercise, Aged, business.industry, Water, 030229 sport sciences, medicine.disease, postexercise hypotension, cardiac rehabilitation, Blood pressure, Physical therapy, Arterial stiffness, business
Abstract

International audience; We aimed to compare blood pressure (BP) responses following moderate-intensity continuous exercise (MICE), high intensity interval exercise (HIIE) in dry land or HIM in immersed condition, using 24-hour ambulatory BP monitoring. Forty-two individuals (65 +/- 7 years, 52% men) with a baseline BP >= 130/85 mm Hg (systolic/diastolic blood pressures [SBP/DBP]) were randomly assigned to perform one of the three following exercises on a stationary cycle: MICE (24 minutes at 50% peak power output) or HIIE in dry land (two sets of 10 minutes with phases of 15 seconds 100% peak power output interspersed by 15 seconds of passive recovery) or HIIE in up-to-the-chest immersed condition. While MICE modified none of the 24-hour average hemodynamic variables, dryland HIIE induced a 24-hour BP decrease (SBP: -3.6 +/- 5.7/DBP: -2.8 +/- 3.0 mm Hg, P < .05) and, to a much greater extent, immersed HIIE (SBP: -6.8 +/- 9.5/DBP: -3.0 +/- 4.5 mm Hg, P < .05). The one condition that modified 24-hour pulse-wave velocity was immersed HIIE (-0.21 +/- 0.30 m/s, P < .05).

Published
2016

11. Sex hormone levels are not associated with progression of renal disease in male patients with T2DM

Author

Bruno Guerci, Jean-Michel Halimi, Pierre Gourdy, Stéphanie Ragot, P. Zaoui, Ronan Roussel, Pierre-Jean Saulnier, Samy Hadjadj, Elise Gand, Dured Dardari, Philippe Sosner, E. Feigerlová, M. Marre, Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Poitiers, Centre hospitalier universitaire de Poitiers (CHU Poitiers), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Biomécanique et génie biomédical (BIM), Centre National de la Recherche Scientifique (CNRS), Department of electrical, electronic and information engineering 'GUGLIELMO MARCONI' [Bologna] (DEI), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Service d'endocrinologie diabétologie et nutrition [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Anne-de-Bretagne, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulouse (UT)-Université de Toulouse (UT)- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UR)-CHU Pontchaillou [Rennes]-Hôpital Anne-de-Bretagne

Subjects
Male, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Population, Renal function, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Gastroenterology, End stage renal disease, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Sex hormone-binding globulin, Internal medicine, Sex Hormone-Binding Globulin, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Testosterone, Prospective Studies, education, ComputingMilieux_MISCELLANEOUS, Aged, Creatinine, education.field_of_study, biology, Estradiol, business.industry, General Medicine, Middle Aged, Androgen, 3. Good health, Cross-Sectional Studies, chemistry, Diabetes Mellitus, Type 2, Sex steroid, Case-Control Studies, biology.protein, Disease Progression, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background Greater renal function decline (RFD) in type 2 diabetes (T2DM) has been suggested in men compared with women, and imbalances in estrogen/androgen levels have been associated with cardiovascular disease mortality in elderly men, but it remains unclear whether sex hormone disequilibrium is related to diabetic nephropathy (DN) in men with T2DM. Objective This study examined the relationship between sex steroid concentrations and renal outcomes in male T2DM patients. Population and methods Total testosterone (T), total estradiol (E2), sex hormone-binding globulin (SHBG), and total and calculated free (cf) E2/T ratios were compared in 735 male T2DM patients with ( n =513) and without ( n =222) DN, using a cross-sectional approach. Also, in a pilot complementary prospective nested case-control cohort, total E2/total T and cfE2/cfT were evaluated according to a hard renal outcome (HRO): end-stage renal disease/doubling of baseline serum creatinine (36 HRO cases, 72 HRO controls) and rate of eGFR decline (68 rapid vs 68 slow RFD). Result With the cross-sectional approach, E2 and cfE2 were higher in DN cases vs DN controls (95.5 vs 86.8pmol/L [ P =0.0246] and 2.59 vs 2.36pmol/L [ P =0.005], respectively). The difference in E2 persisted on multivariate analysis. In the prospective approach, E2 and T concentrations, and total E2/total T and cfE2/cfT2 ratios did not differ in HRO cases vs controls or in patients with rapid vs slow RFD. Conclusion Although positively related to DN in the cross-sectional analysis, progression of renal disease in male patients with T2DM was not related to either sex hormone levels or aromatase index as reflected by E2/T ratio.

Published
2016

12. Whole-Body Strength Training Using a Huber Motion Lab in Coronary Heart Disease Patients

Author

Guiraud, Thibaut, Labrunée, Marc, Pillard, Fabien, Granger, Richard, Bousquet, Marc, Richard, Lisa, Boned, Anne, Pathak, Atul, Gayda, Mathieu, Grémeaux, Vincent, Centre de Rééducation Cardiovasculaire et Pulmonaire [Clinique Saint Orens - Toulouse), Clinique Saint-Orens, Institut des Maladies Métaboliques et Cardiovasculaires ( I2MC ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Hôpital de Rangueil-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de médecine physique et réadaptation [Hôpital Rangueil - Toulouse], Hôpital de Rangueil, Service de Pharmacologie Clinique du CHU de Toulouse, Université Paul Sabatier - Toulouse 3 ( UPS ), Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal, Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] ( PIT ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie ( CIC-P803 ), Université de Bourgogne ( UB ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Pôle Rééducation - Réadaptation (Médecine Physique et Réadaptation) (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), LPG Systems, Valence, France, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service de Pharmacologie Clinique, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital Purpan [Toulouse], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] (PIT), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)

Subjects
endurance, cardiovascular prevention, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, myocardial-infarction, failure, intermittent exercise, resistance exercise, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, lipid oxidation, Physiologic Responses, Oxygen Uptake, Substrate Oxidation, Coronary Heart Disease, skeletal-muscle, cardiac-rehabilitation, secondary prevention
Abstract

International audience; Objective: The aim of this study was to investigate safety, tolerance, relative exercise intensity, and muscle substrate oxidation during sessions performed on a Huber Motion Lab in coronary heart disease patients.Design: After an assessment of (V) over dotO(2) peak, 20 coronary heart disease patients participated in two different exercises performed in random order at 40% and 70% (W40 and W70) of the maximal isometric voluntary contraction.Results: No significant arrhythmia or abnormal blood pressure responses occurred during either session, and no muscle soreness was reported within 48 hrs posttest. The authors found a difference between W40 and W70 sessions for mean (standard deviation) ventilation (25.1% [8%] and 32.1% [9%] of maximal ventilation, respectively; P = 0.04) and a small difference for mean (standard deviation) heart rate (73 [7] and 79 [8] beats/min, respectively; P < 0.01). When compared with the W40, the W70 was associated with higher active energy expenditure (2.4 [0.6] and 3.1 [0.9] Kcal/min, respectively; P < 0.0001) and a similar mean (standard deviation) oxygen uptake (5.5 [1] and 6.6 [1] ml/min per kilogram, respectively; P = 0.07). The qualitative percentages of carbohydrates and lipids oxidized were 71% and 29%, respectively, at W40 and 91% and 9%, respectively, at W70.Conclusions: Both protocols, which consisted of repeating 6-sec phases of contractions with 10 secs of passive recovery on the Huber Motion Lab, seemed to be well tolerated, safe, and feasible in this group of coronary heart disease patients.

Published
2015

13. Muscle VO2 and forearm blood flow repeatability during venous and arterial occlusions in healthy and coronary heart disease subjects

Author

Vincent Gremeaux, Joffrey Drigny, Anil Nigam, Martin Juneau, Mathieu Gayda, CRSN/Faculté de médecine Université de Montréal, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal, Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] ( PIT ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie ( CIC-P803 ), Université de Bourgogne ( UB ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] (PIT), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, medicine.medical_specialty, Physiology, Intraclass correlation, Near-infra red spectroscopy, near-infrared spectroscopy, Coefficient of variation, Coronary Disease, healthy middle aged subjects, Oxygen Consumption, vascular occlusions, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Arterial occlusions, Physiology (medical), Internal medicine, Humans, Medicine, patients with coronary heart disease, skeletal-muscle, repeatability, parameters, noninvasive measurement, exercise, business.industry, Hemodynamics, Healthy subjects, Hematology, Repeatability, Middle Aged, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Arterial occlusion, Coronary heart disease, failure, body regions, Forearm, Regional Blood Flow, Forearm blood flow, Cardiology, Female, oxygen-consumption, Cardiology and Cardiovascular Medicine, business, agreement, performance
Abstract

International audience; This study aims were: 1) to assess forearm blood flow (FBF) and muscle oxygen consumption (mVO(2)) repeatability assessed with near-infra red spectroscopy (NIRS) during venous occlusions (VO) in middle aged healthy subjects and patients with stable coronary heart disease (CHD), 2) to assess the agreement betweenmVO(2) calculated from NIRS signals duringVOand arterial occlusion (AO) in 18 middle aged healthy subjects and 12 patients with CHD. FBF andmVO(2) were measured using NIRS during 2 successive VO (1-min duration), followed by a 5-min AO. Repeatability for FBF and mVO(2) during VO was assessed with intra class correlation (ICC), coefficient of variation (CV %) and agreement between VO and AOmVO(2) was assessed with a Bland and Altman analysis. FBF and mVO(2) during VO were highly reproducible in healthy (FBF: ICC 0.73, CV% 9.75; mVO(2): ICC 0.89, CV% 12.6) and CHD subjects (FBF: ICC 0.95, CV% 10.26; mVO(2): ICC 0.98, CV% 7.92). VO and AO mVO(2) were in agreement in healthy (mean bias: 0.002mL O-2.min(-1).100g(-1)) and CHD subjects (mean bias: 0.014mL O-2.min(-1).100g(-1)). FBF and mVO(2) measured with NIRS during VO and/or AO are highly reproducible methods to assess microvascular function in healthy subjects and stable CHD patients.

Published
2015

14. The influence of sex on renal function decline in people with Type 2 diabetes

Author

Jean-Michel Halimi, S. Hadjadj Samy, Stéphanie Ragot, P. Zaoui, Philippe Sosner, Elise Gand, A. Miot, Yousri Slaoui, Ronan Roussel, A. de Hauteclocque, Vincent Rigalleau, Pierre-Jean Saulnier, Laboratoire de Mathématiques et Applications (LMA-Poitiers), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre EPIC [Institut de Cardiologie de Montréal], and Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Urology, Renal function, Type 2 diabetes, urologic and male genital diseases, Kidney Function Tests, chemistry.chemical_compound, Endocrinology, Sex Factors, Risk Factors, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Renal replacement therapy, Renal Insufficiency, Risk factor, ComputingMilieux_MISCELLANEOUS, Creatinine, business.industry, Middle Aged, medicine.disease, Prognosis, 3. Good health, [STAT]Statistics [stat], chemistry, Diabetes Mellitus, Type 2, Disease Progression, Female, medicine.symptom, business, Kidney disease, Glomerular Filtration Rate
Abstract

AIMS Several reports have suggested a relationship between male sex and albuminuria in Type 2 diabetes, but impact on renal function decline has not been established. Our aim was to describe the influence of sex on renal function decline in Type 2 diabetes. METHODS SURDIAGENE, an inception cohort, consisted in 1470 people with Type 2 diabetes. Patients without renal replacement therapy and with ≥ 3 serum creatinine determinations during follow-up prior to end-stage renal disease were included in the study. Estimated glomerular filtration rate was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Primary outcome was steep estimated glomerular filtration rate (eGFR) decline, defined as a yearly slope value lower than -3.5 ml min(-1) 1.73 m(-2). Secondary outcomes were estimated glomerular filtration rate trajectories according to sex and occurrence of end-stage renal disease. RESULTS A total of 22 914 serum creatinine determinations were considered in 1146 participants (60% men), aged 65 ± 11 years, with a median follow-up duration of 5.7 years (range 0.1-10.2). Median yearly estimated glomerular filtration rate slope was -1.31 ml min(-1) 1.73 m(-2) in women and -1.77 ml min(-1) 1.73 m(-2) in men (P < 0.001). Men were more likely than women to develop end-stage renal disease (22 men vs. 7 women; P(log-rank) = 0.03). Male sex was an independent risk factor of steep estimated glomerular filtration rate decline [adjusted odds ratio = 1.33 (1.02-1.76), P = 0.04] after adjustment for age, time from diagnosis of Type 2 diabetes, glycated haemoglobin, systolic blood pressure and urinary albumin:creatinine ratio. A multivariable linear mixed-effects model showed a significant difference of estimated glomerular filtration rate trajectories between men and women (P < 0.001). CONCLUSION Male sex is an important independent factor associated with renal function decline in Type 2 diabetes.

Published
2014

15. O12 La trajectoire de créatinine chez les diabétiques de type 2 : un bon marqueur pronostique de la survenue d’évènements cardio-vasculaires

Author

Jean-Michel Halimi, Vincent Rigalleau, A. de Hauteclocque, Stéphanie Ragot, Samy Hadjadj, Philippe Sosner, Ronan Roussel, Pierre-Jean Saulnier, Yousri Slaoui, Laboratoire de Mathématiques et Applications (LMA-Poitiers), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre EPIC [Institut de Cardiologie de Montréal], and Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal

Subjects
[STAT]Statistics [stat], [STAT.AP]Statistics [stat]/Applications [stat.AP], Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine, General Medicine, ComputingMilieux_MISCELLANEOUS
Abstract

Introduction Le role deletere de l’atteinte renale sur la survenue de maladies cardio-vasculaires (CV) dans le diabete de type 2 (DT2) a ete montre. La trajectoire de la fonction renale anterieure a la survenue d’un evenement CV est cependant mal caracterisee. L’objectif principal etait d’etudier l’association entre les trajectoires de creatinines seriques (CrS) et la survenue d’evenements CV chez les patients DT2. Patients et methodes Les patients DT2 de la cohorte prospective SURDIAGENE, sans epuration extra-renale, avec un debit de filtration glomerulaire estime (DFGe) > 30 ml/min/1,73 m2, et au moins 3 creatinines seriques (CrS) au cours du suivi ont ete inclus. L’evenement CV etait le critere composite : deces CV ou survenue non fatale d’un accident vasculaire cerebral ou d’un infarctus du myocarde. Les pentes annuelles de CrS issues d’un modele lineaire a effets mixtes representaient les trajectoires globales et les pentes obtenues par regression lineaire simple, les trajectoires individuelles. Resultats Au total, 158 evenements CV et 19 808 CrS sur une duree mediane de suivi de 5,6 ans ont ete consideres chez 1 070 participants (60 % d’hommes) âges de 65 ± 11 ans. La pente annuelle de CrS etait significativement plus elevee chez les patients avec un evenement CV par rapport a ceux sans evenement (9,5 et 3,3 μmol/L respectivement, pinteraction 4,4 μmol/L/an etait independamment associee a la survenue d’evenements CV (HRajuste = 2,38 [1,67–3,33]) apres ajustement sur l’âge, l’albuminurie et les antecedents CV. Une pente annuelle > 4,4 μmol/L calculee sur les 2 premieres annees de suivi etait un facteur pronostique independant d’evenement CV (HRajuste = 1,80 [1,48–2,46]) apres ajustement sur les memes covariables. Conclusion L’evolution annuelle de la creatinine est associee a un sur-risque d’evenement CV. La determination de la pente anuelle de CrS calculee sur 2 ans de suivi peut etre proposee comme facteur pronostique d’evenement CV.

Published
2014

16. Reliability of heart rate measures used to assess post-exercise parasympathetic reactivation

Author

Michel Audiffren, Nicolas Berryman, Louis Bherer, Laurent Bosquet, Said Mekary, Olivier Dupuy, Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE) (MOVE), Université de Poitiers, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, and Université de Poitiers - UFR Sciences Humaines et Arts (Poitiers UFR SHA)

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Physiology, Coefficient of variation, 030204 cardiovascular system & hematology, 03 medical and health sciences, Electrocardiography, Young Adult, 0302 clinical medicine, exercise intensity, Heart Rate, Parasympathetic Nervous System, Predictive Value of Tests, Physiology (medical), Internal medicine, Heart rate, medicine, Heart rate variability, Humans, Exercise, heart rate recovery, Observer Variation, Analysis of Variance, medicine.diagnostic_test, business.industry, autonomic nervous system, heart rate variability, Repeated measures design, Reproducibility of Results, 030229 sport sciences, General Medicine, Recovery of Function, Autonomic nervous system, Standard error, [SCCO.PSYC]Cognitive science/Psychology, Exercise intensity, Cardiology, Physical therapy, Exercise Test, business
Abstract

International audience; SummaryPurposePostexercise HRR (heart rate recovery) and HRV (heart rate variability) are commonly used to asses non‐invasive cardiac autonomic regulation and more particularly reactivation parasympathetic function. Unfortunately, the reliability of postexercise HRR and HRV remains poorly quantified and is still lacking. The aim of this study was to examine absolute and relative reliability of HRR and HRV indices used to assess postexercise cardiac parasympathetic reactivation.MethodsWe studied 30 healthy men, who underwent 10‐minute heart rate recording after cessation of maximal and submaximal intensity exercises. Each condition of testing was repeated twice within 5 ± 2 days after the first one. Standard indexes of HRR and HRV were computed from heart rate and RR intervals.ResultsWe found no significant bias between repeated measures. Relative reliability was assessed with the intraclass coefficient correlation (ICC) and absolute reliability with the standard error measurement (SEM) and coefficient of variation (CV). A large range for ICC was observed for both indexes of HRR and HRV (0·12 < ICC < 0·87 and 0·14 < ICC < 0·97, respectively). The same heterogeneity was observed for absolute reliability (5% < CV < 72% for HRR parameters and 24% < CV < 141% for HRV parameters).ConclusionAccording to our results, ∆60 (the absolute difference between heart rate immediately at the end of exercise and after 60 s) and HFnu (High Frequency expressed in normalized unit; that is, in a percentage of LF+HF) represent the most reliable parameters. In conclusion, we found that the measures used to asses cardiac parasympathetic reactivation were characterized by large random variations and their reliability remains moderate.

Published
2012

17. Whole-body strength training with Huber Motion Lab and traditional strength training in cardiac rehabilitation: A randomized controlled study

Author

Atul Pathak, Daniel Rivière, Fabien Pillard, Marc Labrunee, Mathieu Gayda, Thibaut Guiraud, Vincent Gremeaux, Frédéric Sanguignol, Davy Laroche, Jean-Michel Senard, Florent Besnier, L. Richard, Réeducation Cardio-Vasculaire et Pulmonaire [Clinique de Saint-Orens], Clinique Saint-Orens, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine physique et réadaptation [Hôpital Rangueil - Toulouse], Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service d'exploration de la fonction respiratoire et de médecine du sport, CHU Toulouse [Toulouse], Pôle Rééducation - Réadaptation (Médecine Physique et Réadaptation) (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinique de Bondigoux, Clinique Pasteur, Clinique Pasteur [Toulouse], Montreal Heart Institute - Institut de Cardiologie de Montréal, Centre EPIC [Institut de Cardiologie de Montréal], Université de Montréal (UdeM)-Montreal Heart Institute - Institut de Cardiologie de Montréal, Institut des Maladies Métaboliques et Cardiovasculaires ( I2MC ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Hôpital de Rangueil-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Université de Montréal [Montréal]-Montreal Heart Institute - Institut de Cardiologie de Montréal

Subjects
Adult, Male, medicine.medical_specialty, Strength training, medicine.medical_treatment, Cardiac rehabilitation, Coronary Disease, Isometric exercise, 030204 cardiovascular system & hematology, Isometric contraction, law.invention, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Randomized controlled trial, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, law, Heart rate, Humans, Medicine, Orthopedics and Sports Medicine, Muscle Strength, Muscle, Skeletal, Exercise, Aged, Rehabilitation, business.industry, Resistance training, Resistance Training, 030229 sport sciences, Middle Aged, Anthropometry, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Chest Press, Physical therapy, Female, business
Abstract

International audience; BACKGROUND:Isometric strengthening has been rarely studied in patients with coronary heart disease (CHD), mainly because of possible potential side effects and lack of appropriate and reliable devices.OBJECTIVE:We aimed to compare 2 different modes of resistance training, an isometric mode with the Huber Motion Lab (HML) and traditional strength training (TST), in CHD patients undergoing a cardiac rehabilitation program.DESIGN:We randomly assigned 50 patients to HML or TST. Patients underwent complete blinded evaluation before and after the rehabilitation program, including testing for cardiopulmonary exercise, maximal isometric voluntary contraction, endothelial function and body composition.RESULTS:After 4 weeks of training (16 sessions), the groups did not differ in body composition, anthropometric characteristics, or endothelial function. With HML, peak power output (P=0.035), maximal heart rate (P

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