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3. The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children

Author

Versporten, Ann, Bielicki, Julia, Drapier, Nico, Sharland, Mike, Goossens, Herman, Calle, Graciela Maria, Garrahan, Juan P., Clark, Julia, Cooper, Celia, Blyth, Christopher C., Francis, Joshua Reginald, Alsalman, Jameela, Jansens, Hilde, Mahieu, Ludo, Van Rossom, Paul, Vandewal, Wouter, Lepage, Philippe, Blumental, Sophie, Briquet, Caroline, de Louvain, Catholique, Robbrecht, Dirk, Maton, Pierre, Gabriels, Patrick, Rubic, Zana, Kovacevic, Tanja, Nielsen, Jens Peter, Petersen, Jes Reinholdt, Poorisrisak, Porntiva, Jensen, Lise Heilmann, Laan, Mari, Tamm, Eda, Matsinen, Maire, Rummukainen, Maija-Liisa, Gajdos, Vincent, Olivier, Romain, Le Maréchal, Flore, Martinot, Alain, Prot-Labarthe, Sonia, Lorrot, Mathie, Orbach, Daniel, Pagava, Karaman, Hufnagel, Markus, Knuf, Markus, Schlag, Stephanie A. A., Liese, Johannes, Renner, Lorna, Enimil, Anthony, Awunyo, Marah, Syridou, Garyfallia, Spyridis, Nikos, Critselis, Elena, Kouni, Sofia, Mougkou, Katerina, Ladomenou, Fani, Gkentzi, Despoina, Iosifidis, Elias, Roilides, Emmanuel, Sahu, Suneeta, Murki, Srinivas, Malviya, Manoj, Kalavalapalli, Durga Bhavani, Singh, Sanjeev, Singhal, Tanu, Garg, Garima, Garg, Pankaj, Kler, Neelam, Soltani, Jafar, Jafarpour, Zahra, Pouladfar, Gholamreza, Nicolini, Giangiacomo, Montagnani, Carlotta, Galli, Luisa, Esposito, Susanna, Donaʼ, Daniele, Giaquinto, Carlo, Borgia, Eleonora, DʼArgenio, Patrizia, De Luca, Maia, Centenari, Chiara, Raka, Lul, Omar, Abeer, Al-Mousa, Haifaa, Mozgis, Dzintars, Sviestina, Inese, Burokiene, Sigita, Usonis, Vytautas, Tavchioska, Gabriela, Hargadon-Lowe, Antonia, Zarb, Peter, Borg, Michael A., González Lozano, Carlos Agustín, Zárate Castañon, Patricia, Cancino, Martha E., McCullagh, Bernadette, McCorry, Ann, Gormley, Cairine, Al Maskari, Zaina, Al-Jardani, Amina, Pluta, Magdalena, Rodrigues, Fernanda, Brett, Ana, Esteves, Isabel, Marques, Laura, Ali AlAjmi, Jameela, Claudia Cambrea, Simona, Rashed, Asia N., Mubarak Al Azmi, Aeshah Abdu, Chan, Si Min, Isa, Mas Suhaila, Najdenov, Peter, Čižman, Milan, Unuk, Sibila, Finlayson, Heather, Dramowski, Angela, Maté-Cano, Irene, Soto, Beatriz, Calvo, Cristina, Santiago, Begoña, Saavedra-Lozano, Jesus, Bustinza, Amaya, Escosa-García, Luis, Ureta, Noelia, Tagarro, Alfredo, Barrero, Pedro Terol, Rincon-Lopez, Elena Maria, Abubakar, Ismaela, Aston, Jeff, Heginbothom, Maggie, Satodia, Prakash, Garbash, Mehdi, Johnson, Alison, Sharpe, David, Barton, Christopher, Menson, Esse, Arenas-Lopez, Sara, Luck, Suzanne, Doerholt, Katja, McMaster, Paddy, Caldwell, Neil A., Lunn, Andrew, Drysdale, Simon B., Howe, Rachel, Scorrer, Tim, Gahleitner, Florian, Gupta, Richa, Nash, Clare, Alexander, John, Raman, Mala, Bell, Emily, Rajagopal, Veena, Kohlhoff, Stephan, Cox, Elaine, and Zaoutis, Theoklis

Published
2016
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5. The pediatric endoscopy practice in Italy: A nationwide survey on behalf of the Italian society of pediatric gastroenterology, hepatology and nutrition (SIGENP)

Author

de’Angelis, Gian Luigi, Accomando, Salvatore, Alvisi, Patrizia, Balassone, Valerio, Bramuzzo, Matteo, Campanozzi, Angelo, Cavataio, Francesca, Centenari, Chiara, Chiaro, Andrea, Cisarò, Fabio, Citrano, Michele, Costa, Lorenzo, Cozzali, Rita, D’Adamo, Grazia, D’Altilia, Mario, Di Chio, Teresa, Di Nardo, Giovanni, Dodaro, Natale, Falchetti, Diego, Famiani, Annalisa, Fanti, Lorella, Felici, Enrico, Francavilla, Ruggiero, Gandullia, Paolo, Gatti, Simona, Granata, Antonino, Illiceto, Maria Teresa, Maino, Marta, Malaventura, Cristina, Mantegazza, Cecilia, Martelossi, Stefano, Miele, Erasmo, Monzani, Alice, Muscas, Alessandro, Nicastro, Emanuele, Orizio, Paolo, Pacenza, Caterina, Paci, Monica, Parma, Barbara, Raffaele, Alessandro, Ravelli, Alberto, Romano, Claudio, Strisciuglio, Caterina, Deganello Saccomani, Marco, Norsa, Lorenzo, and Oliva, Salvatore

Published
2019
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7. High Rates of Prescribing Antimicrobials for Prophylaxis in Children and Neonates: Results From the Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey

Author

Hufnagel, Markus Versporten, Ann Bielicki, Julia Drapier, Nico Sherland, Mike Goossens, Herman Maria Calle, Graciela and Clark, Julia Cooper, Celia Blyth, Christopher C. and Francis, Joshua Reginald Alsalman, Jameela Jansen, Hilde and Mahieu, Ludo Van Rossom, Paul Vandewal, Wouter Lepage, Philippe Blumental, Sophie Briquet, Caroline Robbrecht, Dirk and Maton, Pierre Gabriels, Patrick Rubic, Zana Kovacevic, Tanja Nielsen, Jens Peter Petersen, Jes Reinholdt and Poorisrisak, Porntiva Jensen, Lise Heilmann Laan, Mari Tamm, Eda Matsinen, Maire Rummukainen, Maija-Liisa Gajdos, Vincent and Olivier, Romain Le Marechal, Flore Martinot, Alain and Dubos, Francois Lagree, Marion Prot-Labarthe, Sonia Lorrot, Mathie Orbach, Daniel Pagava, Karaman Knuf, Markus and Schlag, Stephanie A. A. Liese, Johannes Renner, Lorna and Enimil, Anthony Awunyo, Marah Syridou, Garyfallia Spyridis, Nikos Critselis, Elena Kouni, Sofia Mougkou, Katerina and Ladomenou, Fani Gkentzi, Despoina Iosifidis, Elias Roilides, Emmanuel Sahu, Suneeta Murki, Srinivas Malviya, Manoj and Kalavalapalli, Durga Bhavani Singh, Sanjeev Singhal, Tanu and Garg, Garima Garg, Pankaj Kler, Neelam Soltani, Jafar and Jafarpour, Zahra Pouladfar, Gholamreza Nicolini, Giangiacomo and Montagnani, Carlotta Galli, Luisa Esposito, Susanna Tenconi, Rossana Lo Vecchio, Andrea Dona, Daniele Giaquinto, Carlo and Borgia, Eleonora D'Argenio, Patrizia De Luca, Maia and Centenari, Chiara Raka, Lul Raka, Denis Omar, Abeer and Al-Mousa, Haifaa Mozgis, Dzintars Sviestina, Inese and Burokiene, Sigita Usonis, Vytautas Tavchioska, Gabriela and Hargadon-Lowe, Antonia Zarb, Peter Borg, Michael A. Gonzalez Lozano, Carlos Agustin Zarate Castanon, Patricia Cancino, Martha E. McCullagh, Bernadette McCorry, Ann Gormley, Cairine and Al Maskari, Zaina Al-Jardani, Amina Pluta, Magdalena and Rodrigues, Fernanda Brett, Ana Esteves, Isabel Marques, Laura AlAjmi, Jameela Ali Cambrea, Simona Claudia Rashed, Asia N. Al Azmi, Aeshah Abdu Mubarak Chan, Si Min Isa, Mas Suhaila Najdenov, Peter Cizman, Milan Unuk, Sibila and Finlayson, Heather Dramowski, Angela Mate-Cano, Irene Soto, Beatriz Calvo, Cristina Santiago, Begona Saavedra-Lozano, Jesus Bustinza, Amaya Escosa-Garcia, Luis Ureta, Noelia and Lopez-Varela, Elisa Rojo, Pablo Tagarro, Alfredo Terol Barrero, Pedro Maria Rincon-Lopez, Elena Abubakar, Ismaela and Aston, Jeff Patel, Mitul Russell, Alison Bedford and Heginbothom, Maggie Satodia, Prakash Garbash, Mehdi Johnson, Alison Sharpe, David Barton, Christopher Menson, Esse and Arenas-Lopez, Sara Luck, Suzanne Doerholt, Katja McMaster, Paddy Caldwell, Neil A. Lunn, Andrew Drysdale, Simon B. and Howe, Rachel Scorrer, Tim Gahleitner, Florian Gupta, Richa and Nash, Clare Alexander, John Raman, Mala Bell, Emily and Rajagopal, Veena Kohlhoff, Stephan Cox, Elaine Nichols, Kristen Zaoutis, Theoklis ARPEC Project Grp

Abstract

Background. This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used for prophylaxis among pediatric patients hospitalized in 41 countries worldwide. Methods. Using the standardized Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey was conducted at 226 pediatric hospitals in 41 countries from October 1 to November 30, 2012. Results. Overall, 17 693 pediatric patients were surveyed and 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242 (32.9%) received at least 1 antimicrobial for prophylactic use. Of 11 899 prescriptions for antimicrobials, 3400 (28.6%) were provided for prophylactic use. Prophylaxis for medical diseases was the indication in 73.4% of cases (2495 of 3400), whereas 26.6% of prescriptions were for surgical diseases (905 of 3400). In approximately half the cases (48.7% [1656 of 3400]), a combination of 2 or more antimicrobials was prescribed. The use of broad-spectrum antibiotics (BSAs), which included tetracyclines, macrolides, lincosamides, and sulfonamides/trimethoprim, was high (51.8% [1761 of 3400]). Broad-spectrum antibiotic use for medical prophylaxis was more common in Asia (risk ratio [RR], 1.322; 95% confidence interval [CI], 1.202-1.653) and more restricted in Australia (RR, 0.619; 95% CI, 0.521-0.736). Prescription of BSA for surgical prophylaxis also varied according to United Nations region. Finally, a high percentage of surgical patients (79.7% [721 of 905]) received their prophylaxis for longer than 1 day. Conclusions. A high proportion of hospitalized children received prophylactic BSAs. This represents a clear target for quality improvement. Collectively speaking, it is critical to reduce total prophylactic prescribing, BSA use, and prolonged prescription.

Published
2019

8. High rates of prescribing antimicrobials for prophylaxis in children and neonates : results from the antibiotic resistance and prescribing in European children point prevalence survey

Author

Hufnagel, Markus, Versporten, Ann, Bielicki, Julia, Drapier, Nico, Sharland, Mike, Goossens, Herman, Sherland, Mike, Maria Calle, Graciela, Clark, Julia, Cooper, Celia, Blyth, Christopher C., Francis, Joshua Reginald, Alsalman, Jameela, Jansen, Hilde, Mahieu, Ludo, Van Rossom, Paul, Vandewal, Wouter, Lepage, Philippe, Blumental, Sophie, Briquet, Caroline, Robbrecht, Dirk, Maton, Pierre, Gabriels, Patrick, Rubic, Zana, Kovacevic, Tanja, Nielsen, Jens Peter, Petersen, Jes Reinholdt, Poorisrisak, Porntiva, Jensen, Lise Heilmann, Laan, Mari, Tamm, Eda, Matsinen, Maire, Rummukainen, Maija-Liisa, Gajdos, Vincent, Olivier, Romain, Le Marechal, Flore, Martinot, Alain, Dubos, Francois, Lagree, Marion, Prot-Labarthe, Sonia, Lorrot, Mathie, Orbach, Daniel, Pagava, Karaman, Knuf, Markus, Schlag, Stephanie A. A., Liese, Johannes, Renner, Lorna, Enimil, Anthony, Awunyo, Marah, Syridou, Garyfallia, Spyridis, Nikos, Critselis, Elena, Kouni, Sofia, Mougkou, Katerina, Ladomenou, Fani, Gkentzi, Despoina, Iosifidis, Elias, Roilides, Emmanuel, Sahu, Suneeta, Murki, Srinivas, Malviya, Manoj, Kalavalapalli, Durga Bhavani, Singh, Sanjeev, Singhal, Tanu, Garg, Garima, Garg, Pankaj, Kler, Neelam, Soltani, Jafar, Jafarpour, Zahra, Pouladfar, Gholamreza, Nicolini, Giangiacomo, Montagnani, Carlotta, Galli, Luisa, Esposito, Susanna, Tenconi, Rossana, Lo Vecchio, Andrea, Dona, Daniele, Giaquinto, Carlo, Borgia, Eleonora, D'Argenio, Patrizia, De Luca, Maia, Centenari, Chiara, Raka, Lul, Raka, Denis, Omar, Abeer, Al-Mousa, Haifaa, Mozgis, Dzintars, Sviestina, Inese, Burokiene, Sigita, Usonis, Vytautas, Tavchioska, Gabriela, Hargadon-Lowe, Antonia, Zarb, Peter, Borg, Michael A., Gonzalez Lozano, Carlos Agustin, Zarate Castanon, Patricia, Cancino, Martha E., McCullagh, Bernadette, McCorry, Ann, Gormley, Cairine, Al Maskari, Zaina, Al-Jardani, Amina, Pluta, Magdalena, Rodrigues, Fernanda, Brett, Ana, Esteves, Isabel, Marques, Laura, AlAjmi, Jameela Ali, Cambrea, Simona Claudia, Rashed, Asia N., Al Azmi, Aeshah Abdu Mubarak, Chan, Si Min, Isa, Mas Suhaila, Najdenov, Peter, Cizman, Milan, Unuk, Sibila, Finlayson, Heather, Dramowski, Angela, Mate-Cano, Irene, Soto, Beatriz, Calvo, Cristina, Santiago, Begona, Saavedra-Lozano, Jesus, Bustinza, Amaya, Escosa-Garcia, Luis, Ureta, Noelia, Lopez-Varela, Elisa, Rojo, Pablo, Tagarro, Alfredo, Terol Barrero, Pedro, Maria Rincon-Lopez, Elena, Abubakar, Ismaela, Aston, Jeff, Patel, Mitul, Russell, Alison Bedford, Heginbothom, Maggie, Satodia, Prakash, Garbash, Mehdi, Johnson, Alison, Sharpe, David, Barton, Christopher, Menson, Esse, Arenas-Lopez, Sara, Luck, Suzanne, Doerholt, Katja, McMaster, Paddy, Caldwell, Neil A., Lunn, Andrew, Drysdale, Simon B., Howe, Rachel, Scorrer, Tim, Gahleitner, Florian, Gupta, Richa, Nash, Clare, Alexander, John, Raman, Mala, Bell, Emily, Rajagopal, Veena, Kohlhoff, Stephan, Cox, Elaine, Nichols, Kristen, Zaoutis, Theoklis, Mahieu, Ludo, and ARPEC Project Grp

Subjects
antimicrobials, inpatients, pediatrics, point-prevalence survey, prophylactic prescribing, Point-prevalence survey, Male, medicine.medical_specialty, medicine.drug_class, Antibiotics, Pediatrics, Drug Prescriptions, 03 medical and health sciences, Surgical prophylaxis, 0302 clinical medicine, Pharmacotherapy, Antibiotic resistance, Anti-Infective Agents, 030225 pediatrics, Internal medicine, medicine, Prevalence, Humans, Medical prescription, Antimicrobials, Inpatients, Prophylactic prescribing, 0303 health sciences, 030306 microbiology, business.industry, Pharmacology. Therapy, Infant, Newborn, Drug Resistance, Microbial, General Medicine, Antibiotic Prophylaxis, Hospitals, Pediatric, Prophylactic Surgery, Drug Utilization, Anti-Bacterial Agents, Hospitalization, Infectious Diseases, Cross-Sectional Studies, Relative risk, Health Care Surveys, Pediatrics, Perinatology and Child Health, Chemoprophylaxis, Drug Therapy, Combination, Female, Human medicine, business, Child, Hospitalized
Abstract

Background: This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used for prophylaxis among pediatric patients hospitalized in 41 countries worldwide.Methods: Using the standardized Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey was conducted at 226 pediatric hospitals in 41 countries from October 1 to November 30, 2012.Results: Overall, 17693 pediatric patients were surveyed and 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242 (32.9%) received at least 1 antimicrobial for prophylactic use. Of 11899 prescriptions for antimicrobials, 3400 (28.6%) were provided for prophylactic use. Prophylaxis for medical diseases was the indication in 73.4% of cases (2495 of 3400), whereas 26.6% of prescriptions were for surgical diseases (905 of 3400). In approximately half the cases (48.7% [1656 of 3400]), a combination of 2 or more antimicrobials was prescribed. The use of broad-spectrum antibiotics (BSAs), which included tetracyclines, macrolides, lincosamides, and sulfonamides/trimethoprim, was high (51.8% [1761 of 3400]). Broad-spectrum antibiotic use for medical prophylaxis was more common in Asia (risk ratio [RR], 1.322; 95% confidence interval [CI], 1.202-1.653) and more restricted in Australia (RR, 0.619; 95% CI, 0.521-0.736). Prescription of BSA for surgical prophylaxis also varied according to United Nations region. Finally, a high percentage of surgical patients (79.7% [721 of 905]) received their prophylaxis for longer than 1 day.Conclusions: A high proportion of hospitalized children received prophylactic BSAs. This represents a clear target for quality improvement. Collectively speaking, it is critical to reduce total prophylactic prescribing, BSA use, and prolonged prescription.

Published
2019

9. The pediatric endoscopy practice in Italy: A nationwide survey on behalf of the Italian society of pediatric gastroenterology, hepatology and nutrition (SIGENP)

Author

Deganello Saccomani, Marco, primary, Norsa, Lorenzo, additional, Oliva, Salvatore, additional, de’Angelis, Gian Luigi, additional, Accomando, Salvatore, additional, Alvisi, Patrizia, additional, Balassone, Valerio, additional, Bramuzzo, Matteo, additional, Campanozzi, Angelo, additional, Cavataio, Francesca, additional, Centenari, Chiara, additional, Chiaro, Andrea, additional, Cisarò, Fabio, additional, Citrano, Michele, additional, Costa, Lorenzo, additional, Cozzali, Rita, additional, D’Adamo, Grazia, additional, D’Altilia, Mario, additional, Di Chio, Teresa, additional, Di Nardo, Giovanni, additional, Dodaro, Natale, additional, Falchetti, Diego, additional, Famiani, Annalisa, additional, Fanti, Lorella, additional, Felici, Enrico, additional, Francavilla, Ruggiero, additional, Gandullia, Paolo, additional, Gatti, Simona, additional, Granata, Antonino, additional, Illiceto, Maria Teresa, additional, Maino, Marta, additional, Malaventura, Cristina, additional, Mantegazza, Cecilia, additional, Martelossi, Stefano, additional, Miele, Erasmo, additional, Monzani, Alice, additional, Muscas, Alessandro, additional, Nicastro, Emanuele, additional, Orizio, Paolo, additional, Pacenza, Caterina, additional, Paci, Monica, additional, Parma, Barbara, additional, Raffaele, Alessandro, additional, Ravelli, Alberto, additional, Romano, Claudio, additional, and Strisciuglio, Caterina, additional

Published
2019
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10. Antibiotic Prescriptions and Prophylaxis in Italian Children. Is It Time to Change? Data from the ARPEC Project

Author

De Luca, Maia, primary, Donà, Daniele, additional, Montagnani, Carlotta, additional, Lo Vecchio, Andrea, additional, Romanengo, Marta, additional, Tagliabue, Claudia, additional, Centenari, Chiara, additional, D’Argenio, Patrizia, additional, Lundin, Rebecca, additional, Giaquinto, Carlo, additional, Galli, Luisa, additional, Guarino, Alfredo, additional, Esposito, Susanna, additional, Sharland, Mike, additional, Versporten, Ann, additional, Goossens, Herman, additional, and Nicolini, Giangiacomo, additional

Published
2016
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11. Genotype-dependency of butyrate efficacy in children with congenital chloride diarrhea

Author

Canani, Roberto, primary, Terrin, Gianluca, additional, Elce, Ausilia, additional, Pezzella, Vincenza, additional, Heinz-Erian, Peter, additional, Pedrolli, Annalisa, additional, Centenari, Chiara, additional, Amato, Felice, additional, Tomaiuolo, Rossella, additional, Calignano, Antonio, additional, Troncone, Riccardo, additional, and Castaldo, Giuseppe, additional

Published
2013
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14. Retrospective Evaluation of the Incidence of Acute Gastroenteritis and Rotavirus Gastroenteritis in Italy.

Author

Centenari, Chiara, Donà, Daniele, Fillol, Florie, Picelli, Gino, Mozzo, Elena, Villa, Marco, Cantarutti, Luigi, and Giaquinto, Carlo

Subjects
*RETROSPECTIVE studies, *GASTROENTERITIS in children, *CHILD mortality, *ROTAVIRUS diseases, *DIAGNOSIS
Abstract

Introduction Acute gastroenteritis (AGE) is one of the most important causes of morbidity and mortality in childhood. Among all the causative agents of AGE, rotavirus (RV) is themost common pathogen. The aim of this study is to estimate the incidence by age group of rotavirus gastroenteritis (RVGE) in children <5 years of age seen at primary care level. This estimation relies on a specifically developed statistical model applied on AGE data reported in the Pedianet database. Materials and Methods This was an observational, retrospective, cohort study using the Pedianet database that included all children aged 12 years with a diagnosis of AGE or acute diarrhea, and registered on the network during the period from January 2002 to December 2008. Since development of the model was specifically based on data collected during the Rotavirus gastroenteritis Epidemiology and Viral types in Europe Accounting for Losses in Public Health and Society Study (REVEAL study), RVGE estimation was restricted to children aged <60 months who experienced an AGE. Results A total of 128,154 children <12 years of age were registered on the Pedianet database during the study period by 83 family pediatricians (FPs). Information on 36,679 episodes of AGE between 2002 and 2008 was collected. Of overall 36,679 AGE cases, 24,275 (66.2%) occurred in children <5 years of age. For children <5 years of age, more than half the episodes of AGE occurred in children between 12 and 35 months. Number of RVGE predicted by themodel ranged from 2,864 to 4,700 cases, allowing for the estimated underreporting as calculated from the patients participating both in the REVEAL study and included in Pedianet. As expected, the highest rate occurred from November to May, whereas a lower incidence was reported during the summer season from June to September. [ABSTRACT FROM AUTHOR]

Published
2015
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15. Identità di genere in pediatria

Author

Chiara Centenari, Gianluca Tornese, Centenari, Chiara, and Tornese, Gianluca

Subjects
gender dysphoria, gender identity, children, adolescents, pediatrics, adolescent, Pediatrics, Perinatology and Child Health
Abstract

N/A

Published
2022

16. Antibiotic Prescriptions and Prophylaxis in Italian Children. Is It Time to Change? Data from the ARPEC Project

Author

Luisa Galli, Daniele Donà, Susanna Esposito, Claudia Tagliabue, Giangiacomo Nicolini, Ann Versporten, Andrea Lo Vecchio, Maia De Luca, Herman Goossens, Patrizia D'Argenio, Rebecca Lundin, Mike Sharland, Chiara Centenari, Alfredo Guarino, Carlo Giaquinto, Carlotta Montagnani, Marta Romanengo, De Luca, Maia, Donà, Daniele, Montagnani, Carlotta, LO VECCHIO, Andrea, Romanengo, Marta, Tagliabue, Claudia, Centenari, Chiara, D'Argenio, Patrizia, Lundin, Rebecca, Giaquinto, Carlo, Galli, Luisa, Guarino, Alfredo, Esposito, Susanna, Sharland, Mike, Versporten, Ann, Goossens, Herman, and Nicolini, Giangiacomo

Subjects
Genetics and Molecular Biology (all), Pediatrics, Time Factors, Antibiotics, lcsh:Medicine, Medicine (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Biochemistry, 0302 clinical medicine, Medicine and Health Sciences, Ethnicities, Medicine, Public and Occupational Health, 030212 general & internal medicine, Antibiotic prophylaxis, Child, lcsh:Science, Multidisciplinary, Respiratory tract infections, Antimicrobials, agricultural and biological sciences (all), biochemistry, genetics and molecular biology (all), medicine (all), Age Factors, Drugs, Bacterial Infections, Vaccination and Immunization, Hospitals, Italian People, Anti-Bacterial Agents, Hospitalization, Italy, Child, Preschool, Drug Therapy, Combination, Female, Pediatric Infections, Engineering sciences. Technology, Research Article, medicine.drug, medicine.medical_specialty, medicine.drug_class, Immunology, Surgical and Invasive Medical Procedures, Microbiology, Drug Prescriptions, 03 medical and health sciences, Pharmacotherapy, Antibiotic resistance, Microbial Control, 030225 pediatrics, Humans, Medical prescription, Pharmacology, Prophylaxis, business.industry, lcsh:R, Infant, Newborn, Biology and Life Sciences, Neonates, Infant, Antibiotic Prophylaxis, medicine.disease, Health Care, Penicillin, Health Care Facilities, Health Care Surveys, People and Places, Population Groupings, lcsh:Q, Preventive Medicine, business, Febrile neutropenia, Developmental Biology
Abstract

Background Antimicrobials are the most commonly prescribed drugs. Many studies have evaluated antibiotic prescriptions in the paediatric outpatient but few studies describing the real antibiotic consumption in Italian children's hospitals have been published. Point-prevalence survey (PPS) has been shown to be a simple, feasible and reliable standardized method for antimicrobials surveillance in children and neonates admitted to the hospital. In this paper, we presented data from a PPS on antimicrobial prescriptions carried out in 7 large Italian paediatric institutions. Methods A 1-day PPS on antibiotic use in hospitalized neonates and children was performed in Italy between October and December 2012 as part of the Antibiotic Resistance and Prescribing in European Children project (ARPEC). Seven institutions in seven Italian cities were involved. The survey included all admitted patients less than 18 years of age present in the ward at 8: 00 am on the day of the survey, who had at least one on-going antibiotic prescription. For all patients data about age, weight, underlying disease, antimicrobial agent, dose and indication for treatment were collected. Results The PPS was performed in 61 wards within 7 Italian institutions. A total of 899 patients were eligible and 349 (38.9%) had an on-going prescription for one or more antibiotics, with variable rates among the hospitals (25.7% -53.8%). We describe antibiotic prescriptions separately in neonates ( = 30 days to

Published
2016

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