232 results on '"Cellular Blue Nevus"'
Search Results
2. Freckles, Lentigos, Melanocytic Nevi, and Melanoma
- Author
-
Ruiz Beguerie, Julieta, de Diego, Clara, Smoller, Bruce, editor, and Bagherani, Nooshin, editor
- Published
- 2022
- Full Text
- View/download PDF
Catalog
3. Blue nevi of the palpebral conjunctiva: report of 2 cases and review of literature.
- Author
-
Suller, Armida L., Zhao, Jiawei, Hodgson, Nickisa M., Erdag, Gulsun, Seethala, Raja R., Ramasubramanian, Aparna, and Fu, Roxana
- Subjects
- *
CONJUNCTIVA , *MELANOMA , *NEVUS , *SURGICAL margin , *DISEASE relapse , *KERATOCONJUNCTIVITIS - Abstract
To describe two patients with blue nevi of the palpebral conjunctiva and to review the existing literature on common and cellular blue nevi of the conjunctiva. Report of two cases and literature review. We present two cases of blue nevi in the palpebral conjunctiva: an atypical cellular blue nevus of the left upper eyelid and a common blue nevus around the lacrimal punctum of the left lower eyelid. Both patients underwent full thickness eyelid excision with wide margins. There was no tumor recurrence at 11 and 4 months postoperatively. Blue nevi are a group of melanocytic tumors that rarely involve the ocular adnexa. They may arise in the palpebral conjunctiva and should be considered in the differential diagnosis of pigmented lesions in this location as they can mimic melanoma. [ABSTRACT FROM AUTHOR] more...
- Published
- 2022
- Full Text
- View/download PDF
4. Mimics of Cutaneous Mesenchymal Tumors
- Author
-
Buehler, Darya, Patel, Rajiv M., Billings, Steven D., Billings, Steven D., editor, Patel, Rajiv M., editor, and Buehler, Darya, editor
- Published
- 2019
- Full Text
- View/download PDF
5. Blue nevus of the nail: A case report and review.
- Author
-
Satolli, Francesca, Gandolfi, Marco, Rovesti, Miriam, Zucchi, Alfredo, Roberta, Manuguerra, Stanganelli, Ignazio, De Felici Del Giudice, Mariabeatrice, Torello, Lotti, and Feliciani, Claudio
- Subjects
- *
NEVUS , *BLUE , *WOMEN patients - Abstract
Blue nevus (BN), in all its clinical variants, rarely affects the nail bed. This leads to difficulty in the diagnosis of BN within the nail bed as well as to challenges with regard to its treatment and follow‐up management, not solely attributed to the intrinsic difficulty of the anatomical site. We present the first case in the literature of an acquired cellular BN entirely confined within the nail bed, in a female Caucasian patient. We propose diagnostic and therapeutic options based on personal clinical and surgical experience. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
- Full Text
- View/download PDF
6. Updates on molecular diagnostic assays in melanocytic pathology.
- Author
-
Andea, Aleodor A.
- Abstract
Melanoma is the leading cause of death among cutaneous neoplasms. For the great majority of melanocytic tumors histopathologic examination can reliably distinguish nevi from melanomas; however, there is a subset of melanocytic neoplasms that defy an accurate diagnosis using histopathological criteria alone. For such tumors, additional ancillary tests would be beneficial in adjudicating a more definitive diagnosis. Conventional ancillary studies such as immunohistochemistry have only a limited utility in distinguishing an atypical nevus from melanoma. In recent years few molecular ancillary tests have been developed to help guide the diagnosis of ambiguous melanocytic proliferations. These tests are based either on the identification of genomic copy number changes or on the differential expression pattern of selected genes in nevi and melanomas. This review will present an updated overview of the major ancillary tests used in clinical practice for the diagnosis of challenging melanocytic neoplasms. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
- Full Text
- View/download PDF
7. A cellular blue nevus with pigmented epithelioid melanocytoma‐like pattern on the ipsilateral upper arm associated with a congenital plaque‐type blue nevus on the hand.
- Author
-
Lee, Min Young, Jin, Suna, Lee, Kyung‐Hwa, Park, Min Ho, Jung, Sung Taek, Rubin, Adam, and Yun, Sook Jung
- Subjects
- *
SKIN biopsy , *HISTOPATHOLOGY , *MELANOCYTES , *ARM diseases , *TUMORS - Abstract
A 36‐year‐old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Skin biopsies from the hand showed a heavily pigmented melanocyte proliferation in the dermis with perieccrine, perivascular, and perineural involvement, and a diagnosis of congenital plaque‐type blue nevus was made. The tumor on the arm was located closely along the median nerve, and was observed as a large black pedunculated round tumor. Histopathologically, the tumor on the arm consisted of densely packed tissue with nevoid cells without atypia in the larger nodular part, and heavily pigmented spindle and epithelioid melanocytes in the slender stalk area, which was diagnosed as cellular blue nevus with pigmented epithelioid melanocytoma‐like pattern. Next‐generation sequencing revealed GNAQ mutations in the hand lesion, and in the lesions on the arm. This case suggests that the areas of skin following the same neural distribution of a congenital plaque‐type blue nevus on the extremities should be followed up for secondary changes. [ABSTRACT FROM AUTHOR] more...
- Published
- 2019
- Full Text
- View/download PDF
8. Nevi
- Author
-
Happle, Rudolf and Happle, Rudolf
- Published
- 2014
- Full Text
- View/download PDF
9. Melanoma Resembling Blue Nevus
- Author
-
Massi, Guido, LeBoit, Philip E., Massi, Guido, and LeBoit, Philip E.
- Published
- 2014
- Full Text
- View/download PDF
10. Spitzoid Melanoma of Childhood
- Author
-
Massi, Guido, LeBoit, Philip E., Massi, Guido, and LeBoit, Philip E.
- Published
- 2014
- Full Text
- View/download PDF
11. Dermal Melanocytosis
- Author
-
Hoang, Mai P., Mihm, Martin C., Jr., Hoang, Mai P., editor, and Mihm Jr., Martin C., editor
- Published
- 2014
- Full Text
- View/download PDF
12. Cancer: Clinical Background and Key Challenges
- Author
-
Llombart-Bosch, Antonio, Ringborg, Ulrik, Rutella, Sergio, Celis, Julio E., Cesario, Alfredo, editor, and Marcus, Frederick, editor
- Published
- 2011
- Full Text
- View/download PDF
13. Melanoma Arising in Blue Nevus
- Author
-
Massi, Guido, Leboit, Philip E., Massi, Guido, and Leboit, Philip E.
- Published
- 2004
- Full Text
- View/download PDF
14. Cerebriform intradermal nevus presenting as cutis verticis gyrata with multiple cellular blue nevus over the body: A rare occurrence
- Author
-
Somenath Sarkar, Soumyajit Roychoudhury, Arpit Shrimal, and Kapildeb Das
- Subjects
Cellular blue nevus ,cutis verticis gyrata ,cerebriform intradermal nevus ,Dermatology ,RL1-803 - Abstract
Cutis verticis gyrata is a rare skin condition characterized by swelling of scalp resembling the surface of the brain. Various conditions, like cerebriform intradermal nevus (CIN), may give rise to this clinical entity. Moreover, its association with cellular blue nevus is extremely rare and has not been reported so far. Here, we report a 28-year-old male with a huge cerebriform swelling covering the occipital lobe along with multiple nodules all over the body. Histology of the scalp swelling showed solitary or clusters of nevus cells in the dermis and from the body lesions showed features of cellular blue nevus. The diagnosis of CIN with cellular blue nevus was confirmed more...
- Published
- 2014
- Full Text
- View/download PDF
15. Blue nevus-like and blue nevus-associated melanoma: a comprehensive review of the literature.
- Author
-
Borgenvik, Thore L., Karlsvik, Tina M., Ray, Saikat, Fawzy, Monica, and James, Nick
- Subjects
- *
MELANOMA , *MELANOCYTES , *SKIN cancer , *DYSPLASTIC nevus syndrome , *SKIN abnormalities - Abstract
Background Malignant blue nevus, blue nevus-associated melanoma and blue nevus-like melanoma are all terms used to describe malignant melanomas arising from, in association with, or resembling blue nevi. This review is aimed at summarizing the available literature to reduce the confusion surrounding this rare malignancy, and aid the surgeon in choosing further diagnostic or therapeutic measures. Methods We conducted a search of Medline, Embase, Science Direct, Scopus and the Cochrane Library for all full text articles published in English that reported on a malignant melanoma arising from, in association with, or resembling a blue nevus. Results We identified 91 cases that fit the criteria above. The mean age at diagnosis was 45 years, with a slight male predominance (males: 48; females: 43). Metastatic cases were reported in 55% ( n = 50), of which 16 were metastatic at the time of diagnosis, 16 developed metastases within the first year and 18 within 5 years of initial diagnosis. The mean Breslow thickness was 6.8 mm at the time of diagnosis ( n = 39). Conclusions The histological criteria for diagnosing this malignancy are very poorly defined, and may contribute to the substantial confusion surrounding the terminology. There is no consensus on which prognostic indicators predictive of outcome in 'conventional' malignant melanoma are applicable to blue nevus-like melanoma/blue nevus-associated melanoma. However, two larger case series have demonstrated a significant association between Breslow thickness (or largest tumour dimension when non-epidermal) and recurrence-free survival, as well as rate of local recurrence, but larger studies are needed to confirm this. [ABSTRACT FROM AUTHOR] more...
- Published
- 2017
- Full Text
- View/download PDF
16. Atypical Cellular Blue Nevus With Necrosis Mimicking Melanoma Ex-Blue Nevus
- Author
-
Jennifer S. Ko, Steven D. Billings, Ania Henning, and Joshua Weaver
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Necrosis ,Dermatology ,Pathology and Forensic Medicine ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Infiltrative Growth Pattern ,Nevus, Blue ,medicine ,Humans ,Nevus ,skin and connective tissue diseases ,Melanoma ,Blue nevus ,business.industry ,Cytologic atypia ,Cellular Blue Nevus ,General Medicine ,medicine.disease ,Pleomorphism (cytology) ,medicine.symptom ,business - Abstract
Histologic distinction between melanoma ex-blue nevus and cellular blue nevus (CBN) can often be difficult, but features supporting melanoma include infiltrative growth pattern, frequent mitoses, cytologic atypia and pleomorphism, cell crowding, and tumor necrosis. Unfortunately, these features are not constantly dependable and frequently borderline lesions exist, so-called atypical CBN, which lack explicit malignant features. Furthermore, some CBN and atypical CBN show an assortment of features, which may lead to their misdiagnosis as melanoma, but to date necrosis is generally absent. We present an unusual case of an atypical cellular blue nevus with extensive necrosis mimicking melanoma ex-blue nevus. more...
- Published
- 2021
- Full Text
- View/download PDF
17. Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature
- Author
-
Pai-Shan Cheng, Shih-Sung Chuang, Tseng-Tong Kuo, and Feng-Jie Lai
- Subjects
animal-type melanoma ,cellular blue nevus ,epithelioid blue nevus ,malignant melanoma ,pigmented epithelioid melanocytoma ,Dermatology ,RL1-803 - Abstract
Pigmented epithelioid melanocytoma (PEM), or animal-type melanoma, is an unusual variant of melanoma which has been reported to have indolent behavior and a relatively good prognosis. We report a 12-year-old girl with PEM on the third finger web of her right hand. Histopathologically, it was composed of heavily pigmented dermal epithelioid and spindled melanocytic tumor cells. A sentinel lymph node biopsy was negative, and no recurrence was noted 1 year later. We reviewed 173 previously published cases of PEM or so-called animal-type melanoma in the literature. Among the 173 cases and our case, extremities were the most common sites of occurrence (52/129, 40.3%), and most of the depth of invasions were Clark level IV and V [76/114 (66.7%) and 33/114 (28.9%), respectively]. Lymph nodes metastasis was noted in 39/89 (43.8%) of the cases being investigated. Only two cases died of the disease with visceral metastasis. Thus, a more advanced level of invasion and the presence of lymph node metastasis did not imply a definitely malignant clinical course, because spreading beyond lymph nodes was rare (5/174, 2.9%). However, long-term follow-up with more cases and further research are needed to fully delineate the true biological nature of this pigmented melanocytic tumor. more...
- Published
- 2012
- Full Text
- View/download PDF
18. Evaluation of Serum Protein S-100 as a New Melanoma Marker
- Author
-
Ghanem, G., Loir, B., Pector, J. C., Ewalenko, P., Kerger, J., Frühling, J., Liénard, D., Lejeune, F., Deraemaecker, R., Altmeyer, Peter, editor, Hoffmann, Klaus, editor, and Stücker, Markus, editor
- Published
- 1997
- Full Text
- View/download PDF
19. Unexpected high fluorine-18 fluorodeoxyglucose uptake on positron emission tomography/computed tomography of a benign cellular blue nevus
- Author
-
Jun Young Kim and Hyun Ji Lee
- Subjects
Infectious Diseases ,Fluorine-18-fluorodeoxyglucose ,business.industry ,Cellular Blue Nevus ,Medicine ,Dermatology ,business ,Nuclear medicine ,Positron Emission Tomography-Computed Tomography - Published
- 2021
- Full Text
- View/download PDF
20. CYSLTR2-mutant Cutaneous Melanocytic Neoplasms Frequently Simulate 'Pigmented Epithelioid Melanocytoma,' Expanding the Morphologic Spectrum of Blue Tumors
- Author
-
Keisuke Goto, Daniel Pissaloux, Franck Tirode, Arnaud de la Fouchardière, and Sandrine Paindavoine
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Pathology and Forensic Medicine ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Nevus, Blue ,Female patient ,Biomarkers, Tumor ,medicine ,Hotspot mutation ,Humans ,Nevus ,Genetic Predisposition to Disease ,skin and connective tissue diseases ,Aged ,Aged, 80 and over ,Receptors, Leukotriene ,BAP1 ,integumentary system ,business.industry ,Tumor Suppressor Proteins ,Melanoma ,Cellular Blue Nevus ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Scalp ,Mutation ,Melanocytes ,Female ,Surgery ,Anatomy ,Melanocytoma ,business ,Melanoma-Specific Antigens ,Ubiquitin Thiolesterase ,gp100 Melanoma Antigen - Abstract
Recurrent activating Gαq mutations in the spectrum of blue nevi have been well studied. However, the clinicopathologic characteristics of the recently described CYSLTR2-mutant and PLCB4-mutant blue nevi remain limited, owing to their rarity. Herein, we present 7 CYSLTR2-mutant melanocytic neoplasms, including 1 cellular blue nevus, 4 atypical cellular blue nevi, and 2 blue nevus-like melanomas. They occurred on the scalp, breast, flank, forearm, thigh, leg, and ankle of 3 male patients and 4 female patients, with a median age of 43 (25 to 81) years at diagnosis. Five exhibited an exophytic growth, and 6 were heavily pigmented. A fascicular arrangement of medium to large spindle melanocytes was seen in 6 cases, but epithelioid cytology was present in only 2 cases, one of them being focal. A junctional component was present in 3 cases. Immunoreactivity for HMB45 was diffusely present, except in 1 cellular blue nevus. BAP1 nuclear immunoexpression was lost in 1 melanoma case. A canonical CYSLTR2 L129Q hotspot mutation was present in all cases. Altogether, these histopathologic findings suggest that CYSLTR2-mutant melanocytic blue neoplasms frequently exhibit a heavily pigmented exophytic tumor with a silhouette resembling "pigmented epithelioid melanocytoma" rather than usual cellular blue nevus. Moreover, most of these tumors were not clinically recognized as blue nevi and not located in the classic topography of cellular blue nevus aside from the scalp. However, a fascicular arrangement of medium to large-sized spindled melanocytes, as well as a lack of epithelioid or nevoid melanocytes, could be potential diagnostic clues to morphologically distinguish CYSLTR2-mutant tumors from "pigmented epithelioid melanocytoma." more...
- Published
- 2019
- Full Text
- View/download PDF
21. Large Plaque-type Blue Nevus with GNAQ Q209P Mutation, Involving Mammary Gland Tissue: Under-Recognized Mammary Condition as an Origin of Primary Mammary Melanocytic Tumors
- Author
-
Takashi Sugino, Kosuke Satake, Keisuke Goto, Kazuaki Nakashima, Tamotsu Sudo, Shusuke Yoshikawa, Tomomi Hayashi, and Yoshio Kiyohara
- Subjects
medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Mammary gland ,Mammary Gland Tissue ,Breast Neoplasms ,Dermatology ,Pathology and Forensic Medicine ,Nevus, Blue ,medicine ,Humans ,skin and connective tissue diseases ,Blue nevus ,Mammary tumor ,business.industry ,Melanoma ,Cellular Blue Nevus ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Mutation ,GTP-Binding Protein alpha Subunits, Gq-G11 ,Histopathology ,Female ,medicine.symptom ,business ,GNAQ - Abstract
Plaque-type blue nevus is a rare variant of blue nevi that was first described in 1954. This article presents clinical, macroscopic, histopathological, and genetic findings for a case of large plaque-type blue nevus expanding into the mammary gland tissue as well as the skin of the right breast. A 63-year-old woman presented with a congenital, large, blue-colored macule limited to the hypochondriac area of the right breast. A nodule 8 mm in diameter was also present in the mammary gland tissue. Magnetic resonance imaging was unable to detect diffuse melanin deposition in the mammary gland tissue, but pigmentation in the whole mammary parenchyma was observed in the cut surfaces of the mastectomy specimen. Histopathology revealed a sparse distribution of dendritic melanocytes in whole sections of the mammary fibrous tissue and partial sections of the dermis. The histopathological criteria for atypical cellular blue nevus were fulfilled for the mammary tumor. Nodal blue nevus was diagnosed in the sentinel lymph node. Sanger sequencing confirmed the GNAQ Q209P mutation, which was also identified in all 4 literature cases of plaque-type blue nevus, but rarely in conventional blue nevi and uveal melanoma. It should be noted that plaque-type blue nevus can expand into the mammary gland tissue, even if the pigmented lesion does not exist on the overlying breast skin. The mammary condition can be the origin of primary mammary melanocytic tumors. Mosaicism of the GNAQ Q209P mutation can be a characteristic genetic alteration to extensive blue nevi, including plaque-type blue nevus. more...
- Published
- 2021
22. Atypia and Differential Diagnosis in Cellular Blue Nevi: Clinicopathological Study of 21 Cases.
- Author
-
YAMAN, Banu, KANDİLOĞLU, Gülşen, SARSİK KUMBARACİ, Banu, and AKA LIN, Taner
- Subjects
- *
NEVUS , *PIGMENTATION disorders , *MELANOMA , *MITOSIS , *LYMPH node diseases - Abstract
Objective: Cellular blue nevus differs from the classic blue nevus with characteristics such as large size, cellularity, intense pigmentation, and growing pattern with subcutaneous infiltration. It is a dermal melanocytic tumor that can be confused with melanoma due to the atypia it may contain. Material and Method: Hematoxylin-eosin and MIB-1 stained slides of 21 cases diagnosed between 2000-2014 were re-evaluated. In order to attract attention to this rare lesion, 21 cases are presented with the clinical and above-mentioned histopathological findings. Results: Thirteen (61.9%) cases were females and eight (38.1%) were male. The mean age was 25.4 (2-73). The most frequent localization was the sacral and gluteal region (11 cases). The mean diameter was 14.4 mm (4-60 mm). From the parameters defined to assess the atypia, ulceration was identified in four cases. Prominent cellularity and subcutaneous infiltration were seen in three and 16 cases, respectively. Mitosis was seen in six tumors. Immunohistochemically, MIB-1 was present in two cases as 3% and 2% respectively, while in others it was 1% or less. Although there is no precise definition for the "atypical cellular blue nevus", five patients were assessed as atypical cellular blue nevus (a case with infiltrative development of six cm tumor diameter, two cases with two mitosis and a MIB-1 index 3% and 2%, a case with one mitosis and confluent development and a case with one mitosis in addition to focal necrosis areas). No lymph node and/or distant metastasis was observed during follow-up. Conclusion: We think it is more important to rule out the possibility of conventional melanoma in cellular blue nevus with exaggerated morphological findings alongside low proliferative activity rather than to determine the atypia. [ABSTRACT FROM AUTHOR] more...
- Published
- 2015
- Full Text
- View/download PDF
23. Cellular blue nevus - A challenging entity: Case report.
- Author
-
Kasturi, Sumalatha, Vemula, Sreenivas, Babu Rendla, Santhosh, Gajula, Narender, and Thota, Ravindra
- Subjects
- *
HISTOLOGY , *MELANOCYTES , *DERMIS , *MELANOMA treatment - Abstract
Blue nevi can present clinically as blue, gray, brown, or black solitary nodules or plaques on the skin. Histologically, they represent collections of melanocytes and melanophages in the dermis. We presented here a case of a cellular blue nevus in a 20 years old man that presented as an enlarging blue-gray nodule on the right buttock. These cases can be challenging both clinically and histologically because malignant melanoma or malignant transformation of a blue nevus could be considered. [ABSTRACT FROM AUTHOR] more...
- Published
- 2015
24. A successfully treated malignant melanoma arising in a large congenital vulvar blue nevus
- Author
-
Pingping Song, Ruiman Li, Weizhao Lin, Xuefeng Jiang, and Xiaoxia Ran
- Subjects
Adult ,Reconstructive surgery ,medicine.medical_specialty ,Local excision ,Skin Neoplasms ,Dermatology ,Vulvar Blue Nevus ,Malignant transformation ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Nevus, Blue ,Humans ,Medicine ,Melanoma ,Blue nevus ,Vulvar Neoplasms ,business.industry ,Cellular Blue Nevus ,General Medicine ,medicine.disease ,female genital diseases and pregnancy complications ,030220 oncology & carcinogenesis ,Female ,Neoplasm Recurrence, Local ,medicine.symptom ,business ,Vulvar melanoma - Abstract
An atypical cellular blue nevus, a benign mass, may sometimes transform into a malignant melanoma. Here, we report a rare case of melanoma arising in a large congenital vulvar blue nevus. A 28-year-old Chinese woman presented to our hospital with a chief complaint of a vulvar mass that had persisted for 8 years. The patient underwent extensive local excision, followed by reconstructive surgery of the female reproductive tract. The mass was diagnosed as being a vulvar malignant melanoma. Postoperatively, the patient received interferon immunotherapy and recovered without complications. No evidence of recurrence was observed after 32 months of follow-up. Our case thus shows that comprehensive treatment with surgery supplemented by immunotherapy can be effective against a malignant melanoma arising in a vulvar blue nevus. more...
- Published
- 2020
- Full Text
- View/download PDF
25. BAP-1 Expression Status by Immunohistochemistry in Cellular Blue Nevus and Blue Nevus-like Melanoma
- Author
-
Victor G. Prieto, Carlos A. Torres-Cabala, Nastaran Neishaboori, Phyu P. Aung, Jonathan L. Curry, Wen-Jen Hwu, Michael T. Tetzlaff, Priyadharsini Nagarajan, Doina Ivan, Wei Shen Chen, and Pei Ling Chen more...
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,animal structures ,Skin Neoplasms ,Adolescent ,Dermatology ,Common Blue Nevus ,complex mixtures ,Protein expression ,Pathology and Forensic Medicine ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Blue Nevus-Like Melanoma ,Nevus, Blue ,polycyclic compounds ,medicine ,Biomarkers, Tumor ,Humans ,Child ,Blue nevus ,Melanoma ,In Situ Hybridization, Fluorescence ,Malignant phenotype ,Chemistry ,Tumor Suppressor Proteins ,Cellular Blue Nevus ,Infant ,General Medicine ,Middle Aged ,Immunohistochemistry ,Child, Preschool ,embryonic structures ,Female ,medicine.symptom ,Ubiquitin Thiolesterase - Abstract
The family of blue nevi includes the common blue nevus (BN), cellular blue nevus (CBN), and atypical BN, while melanomas with BN-like morphology can either arise in association with a blue nevus (MABN) or in the de novo setting mimicking cellular blue nevus (MMCBN). Recent molecular and immunohistochemical studies have demonstrated loss of BAP-1 in MABN/MMCBN but not in BN/CBN, suggesting that loss of BAP-1 correlates with a malignant phenotype in these lesions. In this study, we applied anti-BAP-1 antibodies to a series of CBN/BN (n = 11) and MABN/MMCBN (n = 4). Nuclear BAP-1 expression was detected in the majority of CBN/BN (n = 10/11) but was lost in 1 case. Most cases of MABN/MMCBN showed loss of nuclear BAP-1 expression (n = 3/4), with one case of MMCBN showing preserved BAP-1 expression. Demonstration of BAP-1 loss in a single case of CBN and preservation of BAP-1 expression in 1 case of MMCBN may indicate that detection of alterations in BAP-1 protein expression by immunohistochemistry may not be a completely reliable biomarker for the distinction of BN/CBN from MABN/MMCBN. Further investigation of the significance of BAP-1 loss/preservation in BN-like tumors is warranted. more...
- Published
- 2020
26. A diagnostically‐challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23‐gene expression signature (myPath melanoma)
- Author
-
Joel A. Lefferts, Shaofeng Yan, Dorothea T. Barton, Anh Khoa Pham, Konstantinos Linos, Stephanie A. Castillo, and Julia A. Bridge
- Subjects
Pathology ,medicine.medical_specialty ,Histology ,medicine.diagnostic_test ,business.industry ,Melanoma ,Cellular Blue Nevus ,Dermatology ,medicine.disease ,Pathology and Forensic Medicine ,Molecular analysis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Gene expression ,medicine ,medicine.symptom ,business ,Lymph node ,Blue nevus ,Fluorescence in situ hybridization ,SNP array - Abstract
Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. It was also analyzed by the recently-introduced proprietary 23-gene expression signature test. To the best of our knowledge, this is the second reported case of MEBN analyzed by the 23-gene expression signature, which provided a false-negative result. More studies are needed to assess the sensitivity and specificity of this test in various melanocytic proliferations. more...
- Published
- 2018
- Full Text
- View/download PDF
27. Blue Nevi of the Ocular Surface
- Author
-
Ibrahim O. Sayed-Ahmed, Carol L. Karp, Juan Carlos Murillo, Jan Paul Ulloa, Sander R. Dubovy, James Wong, Maria Paula Fernandez, George W. Elgart, Anat Galor, and Pedro Monsalve
- Subjects
medicine.medical_specialty ,education.field_of_study ,Conjunctiva ,medicine.diagnostic_test ,business.industry ,Ocular Pathology ,Population ,Cellular Blue Nevus ,medicine.disease ,Dermatology ,03 medical and health sciences ,Ophthalmology ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Biopsy ,030221 ophthalmology & optometry ,medicine ,Nevus ,sense organs ,medicine.symptom ,business ,education ,Blue nevus ,Conjunctival Melanoma - Abstract
Purpose Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Design Retrospective, noncomparative case series. Participants Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016. Methods Chart review of patients identified from a database search of the Florida Lions Ocular Pathology Laboratory records. Pathologic diagnoses were confirmed by 2 pathologists (S.R.D. and G.E.). All specimens were bleached and, tissue permitting, stained using SOX10 (MilliporeSigma, Darmstadt, Germany) and CD68 (Leica Biosystems, Nussloch, Germany). Main Outcome Measures Clinical characteristics, pathologic features, and clinical course. Results Mean age of the population was 55±15 years; 71.4% (n = 15) were white and 57.1% (n = 12) were men. One patient had 3 lesions, for a total of 23 lesions examined. Clinically, 13 lesions were on the bulbar conjunctiva, 3 were on the tarsal conjunctiva, 3 were in the fornix, 2 were caruncular, 1 was episcleral, and 1 was at the limbus. Before excision, 8 patients were thought to have primary acquired melanosis, 4 with concern for primary conjunctival melanoma, and 1 thought to have metastatic disease from a plantar melanoma. Five lesions were thought to be benign, and in 8 patients, the lesions were identified incidentally after other ocular surgeries, with no diagnosis of the lesions before excision. Pathologic features were consistent with simple blue nevi in 21 lesions and cellular blue nevus in 2 lesions. No malignant transformations were noted in any patient over the mean 20.2-month follow-up period (range, 2 weeks–103 months). Conclusions Blue nevus is a rare deeply pigmented congenital melanocytic lesion with a benign clinical course that can appear clinically similar to primary acquired melanosis or melanoma. more...
- Published
- 2018
- Full Text
- View/download PDF
28. ALK Rearrangements Are Infrequent in Cellular Blue Nevus and Deep Penetrating Nevus
- Author
-
Jennifer R. Kaley, Sara C. Shalin, Jerad M. Gardner, William T. Bellamy, and Andrew Dunn
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Dermatology ,Pathology and Forensic Medicine ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Nevus, Blue ,Nevus, Epithelioid and Spindle Cell ,hemic and lymphatic diseases ,medicine ,Humans ,Anaplastic lymphoma kinase ,Nevus ,Anaplastic Lymphoma Kinase ,HRAS ,Child ,Aged ,Aged, 80 and over ,Gene Rearrangement ,Chemistry ,ALK Gene Rearrangement ,Cellular Blue Nevus ,Receptor Protein-Tyrosine Kinases ,General Medicine ,Gene rearrangement ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Female ,Immunostaining - Abstract
Recent studies have identified kinase fusions in Spitzoid melanocytic neoplasms, and approximately 10% of Spitzoid neoplasms harbor anaplastic lymphoma kinase (ALK) rearrangements and corresponding ALK immunoreactivity. Deep penetrating nevi (DPN), a subset of melanocytic neoplasms, have histologic and immunohistochemical overlap that have historically supported classification of DPN with blue/cellular blue nevi (CBN). However, HRAS mutations have rarely been detected in DPN, thereby also linking them to Spitz nevi. The purpose of this study was to see if DPN or CBN possess ALK rearrangements, thereby providing more evidence that these melanocytic lesions may be pathogenetically related to Spitzoid neoplasms. Using ALK immunohistochemistry as a surrogate for ALK rearrangement, the authors examined 26 DPN, 30 CBN, and 4 conventional blue nevi. ALK immunoreactive cases underwent fluorescent in situ hybridization to investigate for the presence of ALK gene rearrangement. Patchy and focal ALK immunostaining was found in only 1 case of DPN (1/26, 3.8%). Seven cases of CBN (7/30; 23%) showed ALK immunostaining (6 focal/patchy, 1 strong and diffuse). Fluorescent in situ hybridization using ALK break-apart probes showed various degrees of gain of 2p23 and rare ALK break-apart signals. Four CBN showed ALK rearrangement in 2%-4% of cells. Two cases of CBN showed gain of 2p23 in 10%-20% of cells. In our study, ALK rearrangements are uncommon in both CBN and DPN, making ALK an unlikely driver in tumorigenesis and classification of these melanocytic variants. However, our study did identify ALK molecular changes and immunohistochemical staining patterns that have not been previously described in CBN or DPN. more...
- Published
- 2018
- Full Text
- View/download PDF
29. Cerebriform intradermal nevus presenting as cutis verticis gyrata with multiple cellular blue nevus over the body: A rare occurrence.
- Author
-
Sarkar, Somenath, Roychoudhury, Soumyajit, Shrimal, Arpit, and Das, Kapildeb
- Subjects
DERMIS ,SCALP ,SKIN diseases ,NEVUS ,DISEASES - Abstract
Cutis verticis gyrata is a rare skin condition characterized by swelling of scalp resembling the surface of the brain. Various conditions, like cerebriform intradermal nevus (CIN), may give rise to this clinical entity. Moreover, its association with cellular blue nevus is extremely rare and has not been reported so far. Here, we report a 28-year-old male with a huge cerebriform swelling covering the occipital lobe along with multiple nodules all over the body. Histology of the scalp swelling showed solitary or clusters of nevus cells in the dermis and from the body lesions showed features of cellular blue nevus. The diagnosis of CIN with cellular blue nevus was confirmed. [ABSTRACT FROM AUTHOR] more...
- Published
- 2014
- Full Text
- View/download PDF
30. Large Agminated Cellular 'Plaque-Type' Blue Nevus Surrounding the Ear: A Case and Review.
- Author
-
Spring, P., Perrier, P., Erba, P., Hagmann, P., Mihm, M.C., and Hohl, D.
- Abstract
Large or giant cellular blue nevi are usually congenital and represent a challenge for the physician. Close anatomic structures may be altered by the size of the moles. In this article, we report the case of an uncommon large, agminated, cellular blue nevus of the 'plaque type' in a 42-year-old female. Due to the risks of malignant melanoma development on a large or giant blue nevus, we highlight the importance of proper histopathological diagnosis. Furthermore, because of the possibility that the nevus may invade the bone and cerebral tissues, we discuss the indication of a radiological diagnosis. The accurate correlation to clinical and histopathological findings and appropriate multidisciplinary management can save the lives of patients. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] more...
- Published
- 2013
- Full Text
- View/download PDF
31. Recurrent nodules in a periauricular plaque-type blue nevus with fatal outcome.
- Author
-
Held, Laura, Metzler, Gisela, Eigentler, Thomas K., Leiter, Ulrike, Messina, Jane, Gogel, Jeannette, Bauer, Juergen, and Garbe, Claus
- Subjects
- *
IMMUNOHISTOCHEMISTRY , *NEVUS , *MELANOMA , *MELANOCYTES , *LIVER cancer - Abstract
Plaque-type blue nevus is a rare variant of blue nevus characterized by grouped nodules displaying histomorphological features of a cellular blue nevus. We report the clinical, histopathologic and immunohistologic features of a patient with recurrent nodules in a periauricular plaque-type blue nevus with malignant transformation and fatal outcome. The nevus was characterized clinically by childhood onset, with slow enlargement during adolescence. At age 16, the patient presented with nodules located retroauricularly. Several surgical excisions with the intent of complete removal of the nodules and the nevus were performed. Histopathological, dermal and subcutaneous proliferations of pigmented melanocytes with melanophages were detected. The nodules showed some cellular atypia and few mitotic figures, (Ki67 estimated <1%). At age 20, the patient developed new nodules retroauricular, with histopathology similar to previous lesions; however, the proliferation rate was higher. A comparative genomic hybridization (CGH) showed chromosomal changes indicative of melanoma. At age 25, the patient developed multiple liver metastases and died after 4 weeks. A sequencing of the tumor DNA revealed a GNAQ Q209P mutation, whereas mutations of GNA11, BRAF, NRAS and cKIT were not detected. This case shows that nodules in plaque-type blue nevus may have malignant potential which may be uncovered by CGH. [ABSTRACT FROM AUTHOR] more...
- Published
- 2012
- Full Text
- View/download PDF
32. Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature.
- Author
-
Cheng, Pai-Shan, Chuang, Shih-Sung, Kuo, Tseng-Tong, and Lai, Feng-Jie
- Subjects
MELANOMA ,PROGNOSIS ,HISTOPATHOLOGY ,SENTINEL lymph nodes ,METASTASIS ,LYMPHATICS - Abstract
Abstract: Pigmented epithelioid melanocytoma (PEM), or animal-type melanoma, is an unusual variant of melanoma which has been reported to have indolent behavior and a relatively good prognosis. We report a 12-year-old girl with PEM on the third finger web of her right hand. Histopathologically, it was composed of heavily pigmented dermal epithelioid and spindled melanocytic tumor cells. A sentinel lymph node biopsy was negative, and no recurrence was noted 1 year later. We reviewed 173 previously published cases of PEM or so-called animal-type melanoma in the literature. Among the 173 cases and our case, extremities were the most common sites of occurrence (52/129, 40.3%), and most of the depth of invasions were Clark level IV and V [76/114 (66.7%) and 33/114 (28.9%), respectively]. Lymph nodes metastasis was noted in 39/89 (43.8%) of the cases being investigated. Only two cases died of the disease with visceral metastasis. Thus, a more advanced level of invasion and the presence of lymph node metastasis did not imply a definitely malignant clinical course, because spreading beyond lymph nodes was rare (5/174, 2.9%). However, long-term follow-up with more cases and further research are needed to fully delineate the true biological nature of this pigmented melanocytic tumor. [Copyright &y& Elsevier] more...
- Published
- 2012
- Full Text
- View/download PDF
33. Fluorescence in situ hybridization for distinguishing cellular blue nevi from blue nevus-like melanoma.
- Author
-
Gammon, Bryan, Beilfuss, Beth, Guitart, Joan, Busam, Klaus J, and Gerami, Pedram
- Subjects
- *
MELANOMA , *NEVUS , *FLUORESCENCE in situ hybridization , *MELANOCYTES , *TUMOR necrosis factors - Abstract
Blue nevus-like melanomas are melanomas that arise in association with blue nevi or closely simulate the histopathologic appearance of a blue nevus, usually a cellular blue nevus (CBN). Although the majority of CBN can be readily distinguished from blue nevus-like melanoma by conventional microscopy, there are a subset of cases where this distinction may be exceedingly difficult or impossible. In this study, we evaluated the ability of a fluorescence in situ hybridization (FISH) assay targeting 6p25 (RREB1), 6q23 (MYB), 11q13 (CCND1) and the centromere of chromosome 6 (Cep6) to distinguish between CBN and blue nevus-like melanoma. We identified five cases of blue nevus-like melanoma and 12 cases of CBN. The FISH assay was performed with 100% sensitivity and 100% specificity. Three of five cases met the 6p25/Cep6 criteria, all five met the 6p25 gain criteria and three of five met the 6q23/Cep6 loss criteria. None of the cases met criteria for gains in 11q13. None of the 12 CBN met any criteria for melanoma. A combined analysis of clinical aspects, histopathologic changes and FISH analysis could potentially contribute significantly to the ability of pathologists to discriminate between blue nevus-like melanoma and blue nevi in challenging cases. Gammon B, Beilfuss B, Guitart J, Busam KJ, Gerami P. Fluorescence in situ hybridization for distinguishing cellular blue nevi from blue nevus-like melanoma. [ABSTRACT FROM AUTHOR] more...
- Published
- 2011
- Full Text
- View/download PDF
34. Cellular blue nevus tumor presenting as a submandibular lymph node in a 16-year-old
- Author
-
M. Noonan, H. Sans-Cuellar, L. Boven, Anil Gungor, Cherie-Ann O. Nathan, and N. Dela-Cruz
- Subjects
Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Population ,Neck mass ,Mandible ,Diagnosis, Differential ,03 medical and health sciences ,MART-1 Antigen ,0302 clinical medicine ,Nevus, Blue ,Biomarkers, Tumor ,medicine ,Humans ,skin and connective tissue diseases ,030223 otorhinolaryngology ,education ,Submandibular lymph nodes ,education.field_of_study ,SOXE Transcription Factors ,business.industry ,Cellular Blue Nevus ,Soft tissue ,Melanocytic nevus ,medicine.disease ,Treatment Outcome ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Scalp ,Female ,Lymph Nodes ,Differential diagnosis ,medicine.symptom ,Tomography, X-Ray Computed ,business ,gp100 Melanoma Antigen - Abstract
The cellular blue nevus tumor is a type of dendritic melanocytic nevus that is typically benign and exceedingly rare. The incidence of all blue nevi is about 1%, usually affecting the adult population and appearing on the extremities, sacrococcygeal or gluteal regions. There have only been a handful of case reports cited in the literature where cellular blue nevi present in the head and neck region, usually affecting the scalp and young adult population (7, 8). As such, it is exceedingly rare to encounter a cellular blue nevus tumor in the neck or infiltrating into neck lymph nodes. Here we report a rare case of a cellular blue nevus tumor presenting as a right neck mass in a pediatric 16-year-old patient, shown to invade into the submandibular lymph node and surrounding soft tissue. It is important to be aware of the cellular blue nevus tumor as a differential diagnosis in pediatric neck masses. Histological evaluation is necessary to determine tumor aggression and malignant potential which can guide further treatment in pediatric patients. more...
- Published
- 2021
- Full Text
- View/download PDF
35. So-Called "Malignant Blue Nevus": A Clinicopathologic Study of 23 Patients.
- Author
-
Martin, Richard C. W., Murali, Rajmohan, Scolyer, Richard A., Fitzgerald, Patrick, Colman, Marjorie H., and Thompson, John F.
- Subjects
- *
MELANOMA , *CANCER research , *CLINICAL pathology , *NEUROENDOCRINE tumors , *CYSTS (Pathology) ,TUMOR prognosis - Abstract
The article presents a study on blue nevus-like melanomas (BNLMs). The study reveals that BNLMs tended to demonstrate at a more advanced stage, with thicker main tumors, but had a metastatic pattern like other types of melanoma. It suggests that BNLMs should be dealt in the same way as other variants of melanoma based on pathologic prognostic indices and clinical staging. more...
- Published
- 2009
- Full Text
- View/download PDF
36. Melanocytic “ball-in-mitts” and “microalveolar structures” and their role in the development of cellular blue nevi.
- Author
-
Kazakov, Dmitry V. and Michal, Michal
- Subjects
SKIN ,MELANOCYTES ,HYPOTHESIS ,EPITHELIAL cells - Abstract
Abstract: To test the hypothesis of whether cellular blue nevi (CBN) may originate from “ordinary” compound and dermal nevi, a total of 275 melanocytic nevi including 59 CBN, 34 ordinary blue nevi, 87 combined nevi (including 43 so-called clonal nevi), 35 deep penetrating nevi, and 60 ordinary compound and dermal nevi (30 of each) were studied for the presence of so-called ball-in-mitts and microalveolar structures. A ball-in-mitts structure was defined as a single centrally placed melanocyte with a round to oval nucleus (the “ball” cell) and a clear, dusty, or pigmented cytoplasm encircled by a single dendritic cell (the “mitt” cell) with an oval to spindle-shaped nucleus and slender bipolar processes containing melanin and surrounding at least one fourth of the ball''s diameter. A microalveolar structure was defined as a group of 2 to 10 centrally placed melanocytes with round to oval nuclei and clear, dusty, or pigmented cytoplasm (balls) surrounded by one or more cells (mitts) with spindle-shaped nuclei and slender bipolar processes containing melanin. Microscopically, ball-in-mitt and microalveolar structures were detected in all types of nevi studied, with the highest incidence in combined nevi (82%), CBN (76%), and ordinary “nonblue” nevi (73%). In CBN, ball-in-mitts and microalveolar structures tended to be located in the deeper portion of the lesions, whereas in ordinary nonblue nevi, they were most often found superficially, just below the epidermis; in clonal nevi, these structures were often confined to the “clonal” parts. Immunohistochemically, ball-in-mitts and microalveolar structures were positive for HMB45. Ultrastructurally, the balls tended to have round to oval nuclei, whereas the mitts possessed oval, elongated to spindled nuclei. Melanosomes were found in various stages in the cells of both structures. The cytoplasm of the mitts typically formed elongated polar processes, sometimes with club-like widenings at the ends, completely or partially encircling the balls. In the microalveolar structures, the adjacent cells forming the mitts surrounded the ball cells like a chain. Our study suggests that some or even most cases of CBN may evolve from ordinary nonblue nevi. This process may involve several steps and is probably reflected by the appearances of combined nevi, deep penetrating nevi, and CBN. These nevi often show a morphological overlap, and ball-in-mitts and microalveolar structures found in various stages of their development seem to greatly account for this overlap. [Copyright &y& Elsevier] more...
- Published
- 2007
- Full Text
- View/download PDF
37. Blue Nevi and Related Tumors
- Author
-
Artur Zembowicz
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Clinical Biochemistry ,Biology ,medicine.disease_cause ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Nevus, Blue ,medicine ,Humans ,skin and connective tissue diseases ,Blue nevus ,Mutation ,integumentary system ,GNA11 ,Molecular pathology ,Biochemistry (medical) ,Cellular Blue Nevus ,Neural crest ,030104 developmental biology ,030220 oncology & carcinogenesis ,Disease Progression ,medicine.symptom ,Differential diagnosis ,GNAQ - Abstract
The major entities related to blue nevus are common blue nevus, cellular blue nevus, atypical blue nevus, and malignant blue nevus. These lesions share presence of dermal pigmented dendritic melanocytes derived from embryonal precursors to melanocytes, Schwann cells, and glial cells migrating to the skin from the ventral neural crest. Genetically, blue nevi harbor mutations in G-protein-coupled receptor subunits GNAQ and GNA11. Progression to malignant blue nevus is associated with additional mutations and partial gains and losses of chromosomal material. This article discusses recent advances in pathology of blue nevi with emphasis on differential diagnosis and molecular pathology. more...
- Published
- 2017
- Full Text
- View/download PDF
38. Metastatic Cellular Blue Nevus: A Rare Case With Metastasis Beyond Regional Nodes
- Author
-
Justin Bui, Benjamin A. Wood, Muhammad A. Khattak, Nima Mesbah Ardakani, Andrew Crocker, and Irene Tan
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Dermatology ,Pathology and Forensic Medicine ,Metastasis ,Lesion ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Nevus, Blue ,Rare case ,medicine ,Humans ,Nevus ,Lymph node ,business.industry ,Cellular Blue Nevus ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Lymph ,medicine.symptom ,business - Abstract
In this study, we present a rare case of a 35-year-old man with a long-standing blue-black lesion on his left hand with subsequent infraclavicular and axillary lymph node tumor deposits. The hand lesion and lymph nodes were excised revealing histological, immunohistochemical, and molecular findings consistent with cellular blue nevus. Despite nonregional lymph node involvement, there has been no progression at 12-months follow-up. This is an index case of a cellular blue nevus with metastasis to both regional and nonregional lymph nodes. The lack of atypical/malignant features in this lesion makes the metastatic behavior extraordinary, and hence the prognosis of lesions of this type is indeterminate. more...
- Published
- 2017
- Full Text
- View/download PDF
39. Blue Nevus Developing at a Combined Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination Site: Case Report and Summary of Vaccine-Associated Cutaneous Lesions
- Author
-
Yoo Jung Kim and Philip R. Cohen
- Subjects
medicine.medical_specialty ,Dermatology ,tetanus ,complex mixtures ,vaccine ,medicine ,Nevus ,diphtheria ,skin and connective tissue diseases ,Blue nevus ,blue ,cutaneous ,Tetanus ,business.industry ,pertussis ,Diphtheria ,General Engineering ,Cellular Blue Nevus ,Papule ,vaccination ,medicine.disease ,Vaccination ,Pertussis vaccine ,papule ,deltoid ,medicine.symptom ,business ,nevus ,medicine.drug - Abstract
Skin reaction may develop at the site of vaccine administration. A 54-year-old woman who developed a cellular blue nevus at the site of the combined tetanus, diphtheria, and acellular pertussis (Tdap) vaccine injection four years prior to presentation is described. In addition to blue nevus, other reactions at combined tetanus, diphtheria, and pertussis vaccine injection sites include abscess, deep reactive nodular infiltrates of mixed inflammation, and necrotizing granuloma. In conclusion, blue nevus can be added to the list of cutaneous events that can occur at Tdap vaccination sites. more...
- Published
- 2019
- Full Text
- View/download PDF
40. Atypical Cellular Blue Nevus of the Foot: A Case Report
- Author
-
Lorenzi, Caroline De, Quenan, Sandrine, Ibrahim, Yasmine, Mihm, Martin C, Kaya, Gürkan, and Jr., Martin
- Subjects
ddc:616 ,medicine.medical_specialty ,business.industry ,Cellular Blue Nevus ,Case Report ,Common Blue Nevus ,ddc:616.07 ,lcsh:RL1-803 ,Atypical nevus ,Dermatology ,Malignant blue nevus ,Atypical Nevus ,medicine ,lcsh:Dermatology ,medicine.symptom ,business ,skin and connective tissue diseases ,Blue nevus ,Foot (unit) ,Blue Nevus - Abstract
Blue nevus is a congenital and acquired melanocytic proliferation that includes different histological types. The atypical cellular type has been rarely described and it classically has a benign course. However, because of its intermediate features between common blue nevus and malignant blue nevus, long-term clinical follow-up is required. Here we report the case of a 28-year-old woman who presented with an atypical cellular blue nevus on the right foot. more...
- Published
- 2019
- Full Text
- View/download PDF
41. Recognizing Histopathological Simulators of Melanoma to Avoid Misdiagnosis.
- Author
-
Waqar S, George S, Jean-Baptiste W, Yusuf Ali A, Inyang B, Koshy FS, George K, Poudel P, Chalasani R, Goonathilake MR, and Mohammed L
- Abstract
Melanocytic lesions have a wide morphological spectrum, ranging from benign nevi to malignant melanoma. In contrast to a diagnosis of a benign nevus, a diagnosis of melanoma could mean intensive treatment, lifetime monitoring, and a worse prognosis. Therefore, melanocytic tumors are notoriously challenging and associated with a high risk of litigation in surgical pathology. After describing the basic features of nevi and melanoma, this article describes the detailed clinical and histological features of those lesions that share many similar features with melanoma. The entities included are Spitz nevi and atypical Spitz tumors (AST), Reed nevus, dysplastic nevus, cellular blue nevus (CBN), deep penetrating nevus, combined nevus, recurrent nevus, irritated nevus, congenital pattern nevus, acral nevus, and nevi of special sites. Knowledge of these imitators can help pathologists distinguish between benign and malignant cases and avoid misdiagnosis., Competing Interests: This article has copyrighted material in the form of histopathological images, used with permission from © 2019 Innovative Pathology Press and Archives of Pathology & Laboratory Medicine, © 2010 College of American Pathologists., (Copyright © 2022, Waqar et al.) more...
- Published
- 2022
- Full Text
- View/download PDF
42. Blue nevus with satellitosis: case report and literature review
- Author
-
Bogdana Victoria Kadunc, Ana Flávia de Melo Cavalcanti Shiraishi, Patrícia de Carvalho Sotero, Cínthia Mendes, Ana Helena Kalies Oliveira, and Rafael Fantelli Stelini
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Nevus, blue ,Biopsy ,Case Report ,Dermoscopy ,Dermatology ,Diagnosis, differential ,Malignancy ,Melanocytic lesion ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Female patient ,medicine ,Humans ,Nevus ,skin and connective tissue diseases ,Melanoma ,Blue nevus ,business.industry ,Cellular Blue Nevus ,General Medicine ,medicine.disease ,Malignant blue nevus ,Satellite ,RL1-803 ,030220 oncology & carcinogenesis ,Melanocytes ,Female ,medicine.symptom ,Differential diagnosis ,business - Abstract
Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Many histological subtypes are recognized, the most commons being: common blue nevus, cellular blue nevus, and combined blue nevus. New rare variants have been described in the literature, with emphasis on eruptive blue nevus, plaque, agminate, linear, with satellitosis, disseminated, familial and targetoid. The diagnosis of blue nevus usually presents no difficulties, however, the presence of structures such as irregular edges or satellitosis, are highly suggestive of malignancy, and the differential diagnosis with malignant blue nevus and melanoma with peripheral spread should be considered. We report a case of blue nevus with satellitosis in a 15-year-old female patient. more...
- Published
- 2017
- Full Text
- View/download PDF
43. Genetic profile ofGNAQ-mutated blue melanocytic neoplasms reveals mutations in genes linked to genomic instability and the PI3K pathway
- Author
-
Vicente García-Patos, Javier Cortes, Mileidys Perez-Alea, Juan A. Recio, Javier Hernández-Losa, Ana Vivancos, Ginevra Caratu, Berta Ferrer, Eva Muñoz, and Judit Matito
- Subjects
0301 basic medicine ,Genome instability ,Skin Neoplasms ,DNA Mutational Analysis ,medicine.disease_cause ,Genomic Instability ,blue nevus ,Phosphatidylinositol 3-Kinases ,03 medical and health sciences ,0302 clinical medicine ,GNAQ ,Nevus, Blue ,melanoma ,Humans ,Medicine ,BAP1 ,Epigenetics ,Blue nevus ,ATRX ,Genetics ,Mutation ,business.industry ,Cellular Blue Nevus ,3. Good health ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,GTP-Binding Protein alpha Subunits, Gq-G11 ,medicine.symptom ,business ,genetic profile ,Research Paper - Abstract
Melanomas arising in association with a common or cellular blue nevus (MABN) comprise a relatively rare and heterogeneous group of lethal melanomas. Although GNAQ is known to be frequently mutated in common blue nevus, cellular blue nevus (CBN) and MABN and these malignant lesions present gross chromosome alterations harboring BAP1 mutations, little is known about other mutations that contribute to the development and progression of these neoplasms. Thus, the genetic profile of these tumors is important to increase the number of intervention and treatment modalities. Here, we characterized and genetically profiled two different sections of a rare MABN and two CBNs from three different patients. All of the samples harbored a GNAQ mutation, exhibited RAS pathway activation, and harbored additional mutations in genes associated with genomic instability and epigenetic regulation (KMT2C, FANCD2, ATR, ATRX, NBN, ERCC2, SETD2, and WHSC1). In addition, all neoplasms harbored mutations that directly or indirectly affected either the regulation or activation of the PI3K pathway (PIK3CA, NF1, INPP5B and GSK3B). Our results not only help understand the genetic complexity of these blue melanocytic lesions but provide a rationale to use the combination of PI3K/MTOR and MEK1/2 inhibitors against these types of tumors. more...
- Published
- 2016
- Full Text
- View/download PDF
44. Genomic copy number analysis of a spectrum of blue nevi identifies recurrent aberrations of entire chromosomal arms in melanoma ex blue nevus
- Author
-
Alison B. Durham, Patrick Robichaud, Timothy M. Johnson, Aleodor A. Andea, Min Wang, May P. Chan, Douglas R. Fullen, Paul W. Harms, Rajiv M. Patel, and Gary J. Fisher
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,DNA Mutational Analysis ,Gene Dosage ,Copy number analysis ,Biology ,Gene mutation ,Pathology and Forensic Medicine ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Nevus, Blue ,medicine ,Humans ,Nevus ,Child ,skin and connective tissue diseases ,Melanoma ,neoplasms ,Blue nevus ,Oligonucleotide Array Sequence Analysis ,Aged, 80 and over ,Chromosome Aberrations ,integumentary system ,GNA11 ,Cellular Blue Nevus ,Middle Aged ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,Microdissection ,GNAQ - Abstract
Blue nevi may display significant atypia or undergo malignant transformation. Morphologic diagnosis of this spectrum of lesions is notoriously difficult, and molecular tools are increasingly used to improve diagnostic accuracy. We studied copy number aberrations in a cohort of cellular blue nevi, atypical cellular blue nevi, and melanomas ex blue nevi using Affymetrix's OncoScan platform. Cases with sufficient DNA were analyzed for GNAQ, GNA11, and HRAS mutations. Copy number aberrations were detected in 0 of 5 (0%) cellular blue nevi, 3 of 12 (25%) atypical cellular blue nevi, and 6 of 9 (67%) melanomas ex blue nevi. None of the atypical cellular blue nevi displayed more than one aberration, whereas complex aberrations involving four or more regions were seen exclusively in melanomas ex blue nevi. Gains and losses of entire chromosomal arms were identified in four of five melanomas ex blue nevi with copy number aberrations. In particular, gains of 1q, 4p, 6p, and 8q, and losses of 1p and 4q were each found in at least two melanomas. Whole chromosome aberrations were also common, and represented the sole finding in one atypical cellular blue nevus. When seen in melanomas, however, whole chromosome aberrations were invariably accompanied by partial aberrations of other chromosomes. Three melanomas ex blue nevi harbored aberrations, which were absent or negligible in their precursor components, suggesting progression in tumor biology. Gene mutations involving GNAQ and GNA11 were each detected in two of eight melanomas ex blue nevi. In conclusion, copy number aberrations are more common and often complex in melanomas ex blue nevi compared with cellular and atypical cellular blue nevi. Identification of recurrent gains and losses of entire chromosomal arms in melanomas ex blue nevi suggests that development of new probes targeting these regions may improve detection and risk stratification of these lesions. more...
- Published
- 2016
- Full Text
- View/download PDF
45. Orbital cellular blue nevus complicated by malignant melanoma
- Author
-
Navdeep Nijhawan, Michael Sidiropoulos, Sunit Das, David G. Munoz, and Ahsen Hussain
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Biopsy ,Melanoma ,Cellular Blue Nevus ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Dermatology ,Diagnosis, Differential ,Neoplasms, Multiple Primary ,03 medical and health sciences ,Ophthalmology ,0302 clinical medicine ,Nevus, Blue ,030220 oncology & carcinogenesis ,030221 ophthalmology & optometry ,Humans ,Orbital Neoplasms ,Medicine ,business - Published
- 2017
- Full Text
- View/download PDF
46. A Practical Approach to the Diagnosis of Melanocytic Lesions
- Author
-
Nathan T. Harvey and Benjamin A. Wood
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Lymph node biopsy ,In situ hybridization ,Dermatology ,Pathology and Forensic Medicine ,Surgical pathology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Copy-number variation ,Melanoma diagnosis ,Melanoma ,Pathology, Clinical ,medicine.diagnostic_test ,business.industry ,Cellular Blue Nevus ,General Medicine ,Clinical method ,Medical Laboratory Technology ,030104 developmental biology ,030220 oncology & carcinogenesis ,business ,Comparative genomic hybridization - Abstract
Context.—Melanocytic lesions are common in routine surgical pathology. Although the majority of these lesions can be confidently diagnosed using well-established morphologic criteria, there is a significant subset of lesions that can be diagnostically difficult. These can be a source of anxiety for patients, clinicians, and pathologists, and the potential consequences of a missed diagnosis of melanoma are serious.Objective.—To provide a practical approach to the diagnosis of melanocytic lesions, including classic problem areas as well as suggestions for common challenges and appropriate incorporation of ancillary molecular techniques.Data Sources.—Literature search using PubMed and Google Scholar, incorporating numerous search terms relevant to the particular section, combined with contemporaneous texts and lessons from personal experience.Conclusions.—Although a subset of melanocytic lesions can be diagnostically challenging, the combination of a methodical approach to histologic assessment, knowledge of potential diagnostic pitfalls, opinions from trusted colleagues, and judicious use of ancillary techniques can help the pathologist navigate this difficult area. more...
- Published
- 2018
47. Angiomatoid giant cellular blue nevus of vaginal wall associated with pregnancy
- Author
-
Al-Shraim Mubarak M
- Subjects
Cellular blue nevus ,vagina ,pregnancy ,melanocytes ,Pathology ,RB1-214 - Abstract
Abstract Background Blue nevi that arise from the Müllerian tract are rare melanocytic lesions. Several histopathologic variants of cellular blue nevi have been described. The angiomatoid variant is characterized by a vascular component, and is considered to be a rare variant. Few studies have explored the influence of pregnancy on melanocytic lesions. Case A 29-year-old woman was presented with a pigmented vaginal lesion that increased gradually during pregnancy. A full term gynecologic examination showed a tumor mass protruding into the vaginal canal. The mass was resected during cesarean-section under the clinical impression of vaginal hemangioma. Result Gross examination revealed a cystic mass measuring 6.0 × 4.3 × 3.5 cm, which was filled with dark friable material. Histologically, the mass showed a subepithelial cellular proliferation of heavily pigmented dendritic melanocytes with prominent vascular stroma. Cytologic pleomorphism, junctional activity, atypical mitosis, and necrosis were not found. The proliferation was immunoreactive for HMB-45, S-100 and melan-A, and non-immunoreactive for CD34, smooth muscle actin, and AE1/AE3. The MIB-1 proliferative index was less than 1%. The patient had a postoperative course without complication. Conclusions Angiomatoid giant cellular blue nevus arising from the vagina during pregnancy is extremely rare. The low proliferative index and absence of cytologic pleomorphism, or necrosis, supports a benign biological behavior. Clinical follow-up showed no evidence of recurrence at one year after the resection of the mass. more...
- Published
- 2011
- Full Text
- View/download PDF
48. Oral melanocytic nevi: a clinicopathologic study of 100 cases
- Author
-
Allison Readinger, Harvey P Kessler, Rouba Assi, Leticia Ferreira, and Bruno C. Jham
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Junctional nevus ,Pathology and Forensic Medicine ,Oral and maxillofacial pathology ,medicine ,Humans ,Nevus ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Vermilion border ,Child ,skin and connective tissue diseases ,Aged ,Aged, 80 and over ,Mouth neoplasm ,Nevus, Pigmented ,business.industry ,Cellular Blue Nevus ,Middle Aged ,Compound nevus ,medicine.disease ,Dermatology ,stomatognathic diseases ,medicine.anatomical_structure ,Child, Preschool ,Dysplastic nevus ,Female ,Mouth Neoplasms ,Surgery ,Oral Surgery ,business - Abstract
Objective The purpose of this study was to evaluate the clinical and histopathologic features of oral melanocytic nevi (OMN). Study Design One hundred cases of OMN were retrieved from the files of two oral pathology services, and the data were analyzed with regard to histologic type and clinical features. Results Intramucosal nevus was the most common type (61%), followed by common blue nevus (23%), compound nevus (7%), and junctional nevus (3%). Combined nevus and cellular blue nevus were rare (2% each). The hard palate was the most commonly affected site (33%), followed by the buccal mucosa (18%), vermilion border of the lip (18%), and gingiva (15%). An interesting case of intramucosal nevus with lipomatosus-like changes and neurotization and two cases of oral dysplastic nevus are also reported. Conclusions Intramucosal and common blue nevi are the most common types of OMN. Dysplastic nevus, which is recognized as a marker for melanoma in the skin, can rarely involve the oral cavity. Accordingly, dentists, especially oral and maxillofacial pathologists, should become familiar with the clinical and histopathologic features of this entity. more...
- Published
- 2015
- Full Text
- View/download PDF
49. Cellular blue nevus of the vulva mimicking Bartholin's gland abscess in a 15-year-old girl: a case report.
- Author
-
Yamazhan, Mustafa, Ertas, Ibrahim, Kandiloglu, Gulsen, and Ozeren, Mehmet
- Subjects
- *
NEVUS , *BARTHOLIN'S gland , *ABSCESSES , *MYOMETRIUM , *VULVAR cancer , *HYSTERECTOMY , *DIFFERENTIAL diagnosis , *SYSTEMATIC reviews - Abstract
Introduction: Literature review revealed descriptions of three cellular blue nevus (CBN) in the gynecologic tract. Two of them were myometrial CBN and incidental findings in hysterectomies performed in women aged 37 and 48 years. The single ectocervical CBN involving the hymenal ring and vagina was reported in a 19-year-old woman. The other reported cases of cervical blue nevi were common type and have been localized to endocervix. Case report: Vulvar CBN in left labia majora mimicking Bartholin's gland abscess in a 15-year-old white virgin girl and also the youngest case has not been reported previously. Conclusion: CBN should be considered in the differential diagnosis of vulvar masses in adolescent period. [ABSTRACT FROM AUTHOR] more...
- Published
- 2012
- Full Text
- View/download PDF
50. Giant congenital cellular blue nevus of the scalp: neonatal presentation and approach.
- Author
-
Debyser, Martine, De Schepper, Sofie, D'haese, James, De Ketelaere, Veerle, and Cornette, Luc
- Subjects
- *
HEMORRHAGIC shock , *NEWBORN infants , *HYPOTHERMIA , *SHOCK (Pathology) , *HEMATOMA - Abstract
The authors report the case of a massive vaginal bleeding during labor and delivery, resulting in the birth of a newborn infant in hypovolemic shock. The origin of the bleeding was a giant congenital cellular blue nevus (CBN) of the scalp. The report illustrates the crucial role of immediate and aggressive volume resuscitation, suturing of the skin dehiscence, and firm external compression. This therapy was combined with whole-body hypothermia. The neurological outcome of the patient was normal. A shiny blue mass on the scalp should alert neonatologists to the possibility of a blue nevus of the scalp, rather than a simple scalp hematoma. Final diagnosis is made by biopsy and histologic examination. Early surgical intervention is necessary to prevent malignant degeneration and metastasis. A multidisciplinary approach involving a pediatrician/neonatologist, dermatologist, and surgeon is thus needed for diagnosis, treatment, and long-term follow-up [ABSTRACT FROM AUTHOR] more...
- Published
- 2012
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.