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1,584 results on '"Celik I"'

4. Shell evolution approaching the N=20 island of inversion: structure of 26Na

Author

Wilson, G. L., Catford, W. N., Orr, N. A., Diget, C. Aa., Matta, A., Hackman, G., Williams, S. J., Celik, I. C., Achouri, N. L., Falou, H. Al, Ashley, R., Austin, R. A. E., Ball, G. C., Blackmon, J. C., Boston, A. J., Boston, H. C., Brown, S. M., Cross, D. S., Djongolov, M., Drake, T. E., Hager, U., Fox, S. P., Fulton, B. R., Galinski, N., Garnsworthy, A. B., Jamieson, D., Kanungo, R., Leach, K. G., Orce, J. N., Pearson, C. J., Porter-Peden, M., Sarazin, F., Simpson, E. C., Sjue, S., Smalley, D., Sumithrarachchi, C., Svensson, C. E., Triambak, S., Unsworth, C., and Wadsworth, R.

Subjects
Nuclear Experiment
Abstract

The levels in 26Na with single particle character have been observed for the first time using the d(25Na,p gamma) reaction at 5 MeV/nucleon. The measured excitation energies and the deduced spectroscopic factors are in good overall agreement with (0+1) hbar-omega shell model calculations performed in a complete spsdfp basis and incorporating a reduction in the N=20 gap. Notably, the 1p3/2 neutron configuration was found to play an enhanced role in the structure of the low-lying negative parity states in 26Na, compared to the isotone 28Al. Thus, the lowering of the 1p3/2 orbital relative to the 0f7/2 occurring in the neighbouring Z=10 and 12 nuclei -- 25,27Ne and 27,29Mg -- is seen also to occur at Z=11 and further strengthens the constraints on the modelling of the transition into the island of inversion., Comment: 6 figures

Published
2015
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7. 160TiP Safety and antitumor activity of GEN1042 in combination with pembrolizumab ± chemotherapy in solid tumors: Phase IIb dose-expansion trial in progress

Author

Melero, I., primary, Grande, E., additional, Johnson, M.L., additional, Bauman, J.R., additional, Garcia, V. Moreno, additional, Adkins, D.R., additional, De Miguel, M.J., additional, Perez, D. Roda, additional, Gattoni-Celli, S., additional, Celik, I., additional, Steinberg, J., additional, Ong, T.J., additional, and Felip, E., additional

Published
2023
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9. Exploring the determinants of artificial intelligence (AI) literacy:digital divide, computational thinking, cognitive absorption

Author

Celik, I. (Ismail) and Celik, I. (Ismail)

Abstract

To effectively utilize artificial intelligence (AI)-based technologies such as ChatGPT and realize their novel ethical issues, individuals must have a variety of knowledge and skills about AI. Such knowledge and skills have led to the emergence of AI literacy. Despite the importance of AI literacy in everyday life, little is known about its determinants. To better understand the determinants of AI literacy, we attempted to build a research model relying on previous research and different theoretical frameworks. The model incorporated digital divide, cognitive absorption, and computational thinking. As a major finding from the current study, computational thinking was found to be a significant determinant of AI literacy, which facilitate using, recognizing, and evaluating AI-based technologies. Moreover, we found out that individuals with physical access to information and communication technologies (ICTs) are more expected to use and recognize AI. Also, motivation and skills in using ICTs enable individuals to better evaluate the outcomes of AI-based technologies. The findings also showed that convenient access to ICTs contributes to a deep involvement with AI-based technologies in the use. Further, individuals with higher motivation and skills to use AI technologies are likely to have a pleasant experience after using these technologies.

Published
2023

10. Transparency and trustworthiness in user intentions to follow career recommendations from a learning analytics tool

Author

Gedrimiene, E. (Egle), Celik, I. (Ismail), Mäkitalo, K. (Kati), Muukkonen, H. (Hanni), Gedrimiene, E. (Egle), Celik, I. (Ismail), Mäkitalo, K. (Kati), and Muukkonen, H. (Hanni)

Abstract

Transparency and trustworthiness are among the key requirements for the ethical use of learning analytics (LA) and artificial intelligence (AI) in the context of social inclusion and equity. However, research on these issues pertaining to users is lacking, leaving it unclear as to how transparent and trustworthy current LA tools are for their users and how perceptions of these variables relate to user behaviour. In this study, we investigate user experiences of an LA tool in the context of career guidance, which plays a crucial role in supporting nonlinear career pathways for individuals. We review the ethical challenges of big data, AI, and LA in connection to career guidance and analyze the user experiences (N = 106) of the LA career guidance tool, which recommends study programs and institutions to users. Results indicate that the LA career guidance tool was evaluated as trustworthy but not transparent. Accuracy was found to be a stronger predictor for the intention to follow on the recommendations of the LA guidance tool than was understanding the origins of the recommendation. The user’s age emerged as an important factor in their assessment of transparency. We discuss the implications of these findings and suggest emphasizing accuracy in the development of LA tools for career guidance.

Published
2023

11. Hemmung des EGF-R/VEGF-R durch einen dualen Tyrosinkinaseinhibitor (AEE 788®), ein neuer Therapieansatz beim Schilddrüsenkarzinom?

Author

Hoffmann, S., Burchert, A., Wunderlich, A., Maschuw, K., Celik, I., Zielke, A., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
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12. The relationship between thorax computed tomography findings and prognosis in patients diagnosed with COVID-19.

Author

AKTAS, E., SEBER, T., CAGIR, U., SEBER, T. UYLAR, GUZEL, D. KAMALAK, SAVRANLAR, A., TOKMAK, T. T., and CELIK, I.

Abstract

OBJECTIVE: This study aimed to demonstrate the relationship between thorax computed tomography (CT) findings at the time of admission and prognosis using a semiquantitative CT severity scoring system in patients diagnosed with coronavirus disease 2019 (COVID-19) who tested positive for reverse transcriptase polymerase chain reaction (RT-PCR). PATIENTS AND METHODS: A total of 305 patients aged 18 years and older who were diagnosed with COVID-19 confirmed by RT-PCR and underwent thorax CT at the time of admission, were included in the study between March and July 2020. The demographic data of the patients, their presenting complaints at the time of admission, RT-PCR results, and thorax CT images were scanned retrospectively from electronic medical records. Lesions on thorax CT were evaluated for the presence of ground glass opacity, consolidation, and septal thickening and scoring. RESULTS: No significant relationship was found between mortality and CT score or other parameters. A significant relationship was found between admission to the intensive care unit and CT scoring (p=0.014), aortic diameter (p=0.032), chronic pulmonary disease (p=0.004), halo sign (p=0.031), mortality (p<0.001), fever (p=0.038), and dyspnea (p=0.031). A statistically significant difference was detected in the score parameter between discharged patients and intensive care unit patients who survived and those who died (p<0.001). In the parameter of the number of lobes, a statistically significant difference was found only between discharged patients and intensive care unit patients who survived (p=0.016). CONCLUSIONS: Thorax CT is an advisor for early diagnosis, treatment, and prognosis assessment of the disease. Semiquantitative CT severity scoring can provide valuable information about the prognosis of the patient. [ABSTRACT FROM AUTHOR]

Published
2023

13. The burden and epidemiology of community-acquired central nervous system infections: a multinational study

Author

Erdem, H., Inan, A., Guven, E., Hargreaves, S., Larsen, L., Shehata, G., Pernicova, E., Khan, E., Bastakova, L., Namani, S., Harxhi, A., Roganovic, T., Lakatos, B., Uysal, S., Sipahi, O. R., Crisan, A., Miftode, E., Stebel, R., Jegorovic, B., Fehér, Z., Jekkel, C., Pandak, N., Moravveji, A., Yilmaz, H., Khalifa, A., Musabak, U., Yilmaz, S., Jouhar, A., Oztoprak, N., Argemi, X., Baldeyrou, M., Bellaud, G., Moroti, R. V., Hasbun, R., Salazar, L., Tekin, R., Canestri, A., Čalkić, L., Praticò, L., Yilmaz-Karadag, F., Santos, L., Pinto, A., Kaptan, F., Bossi, P., Aron, J., Duissenova, A., Shopayeva, G., Utaganov, B., Grgic, S., Ersoz, G., Wu, A. K. L., Lung, K. C., Bruzsa, A., Radic, L. B., Kahraman, H., Momen-Heravi, M., Kulzhanova, S., Rigo, F., Konkayeva, M., Smagulova, Z., Tang, T., Chan, P., Ahmetagic, S., Porobic-Jahic, H., Moradi, F., Kaya, S., Cag, Y., Bohr, A., Artuk, C., Celik, I., Amsilli, M., Gul, H. C., Cascio, A., Lanzafame, M., and Nassar, M.

Published
2017
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14. The Anthroscape Approach in Sustainable Land Use

Author

Eswaran, H., Berberoğlu, S., Cangir, C., Boyraz, D., Zucca, C., Özevren, E., Yazıcı, E., Zdruli, P., Dingil, M., Dönmez, C., Akça, E., Çelik, I., Watanabe, T., Koca, Y. K., Montanarella, L., Cherlet, M., Kapur, S., Kapur, Selim, editor, Eswaran, Hari, editor, and Blum, Winfried E.H., editor

Published
2011
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16. In vitro und in vivo Analyse der Wirkung von Vitamin C und Gemcitabine auf eine humane Pankreaskarzinom- Zelllinie (BxPC-3) sowie HUVEC’s und die Tumorinhibition im Pankreaskarzinom SCID-Maus-Modell

Author

Dietz, Carsten, Bühne, I., McGregor, G. P., Hennig, S., Soulaiman, M., Karakas, E., Dederichs, F., Eitner, S., Celik, I., Rothmund, M., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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18. Effektive Tumortherapie in SCID-Mäusen durch koagulationsaktives Antithrombin III

Author

Celik, I., Dietz, C., Sürücü, O., Karakas, E., Hennig, S., Soulaiman, M., Kisker, O., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Kremer, B., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Junginger, T., editor, Senninger, N., editor, Allgayer, H., editor, Broll, R., editor, Bruns, C. J., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Brückner, U. B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Biemer, E., editor, Germann, G., editor, Haas, N., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Rogiers, X., editor, Jauch, K. W., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Celik, I., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Neuhaus, P., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Zerkowski, H. R., editor, Becker, H. D., editor, Saeger, H. -D., editor, Jauch, K. -W., editor, and Bauer, H., editor

Published
2006
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19. Exploring Wild Tomato Species for Morphological Traits, Mineral Elements and Known Disease Resistance Genes.

Author

Kabas, A., Celik, I., Sonmez, I., Kabas, O., and Ilbi, H.

Subjects
*TOMATO breeding, *SPECIES, *MINERAL analysis, *NUTRITIONAL value, *MINERALS
Abstract

Tomato is one of the worldwide major foods consumed fresh, cooked, or processed. Mineral elements, vitamins, and antioxidant content of tomatoes are of interest because of their nutritional value and beneficial health effects. The present study was performed to evaluate the macro- and micro-elements contents of leaves and fruits of seven wild tomato species, in addition to morphological traits. Wild tomato species had variations for all elements in fruits. Coefficient of variation was calculated for elements as 18.50 to 94.32% for potassium and phosphor, respectively. Most of the wild tomato species had higher content of all mineral elements than cultivated tomato. Resistance genes (Frl, I-2, I-3, Mi-3, Pto Ty-1, Ty-3 and Sw-5) of wild tomato species were screened using molecular markers. LA1971, with six resistant genes, and LA1393 and LA1777, with five resistant genes, were considered the most promising parental candidates for breeding. The results of the analysis of mineral elements of seven wild tomatoes species are useful for future tomato breeding. [ABSTRACT FROM AUTHOR]

Published
2023
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20. 1072TiP Phase I/II dose escalation/expansion trial to evaluate safety and preliminary efficacy of DuoBody-EpCAM×4-1BB (BNT314/GEN1059) alone or in combination with an immune checkpoint inhibitor in patients with malignant solid tumors

Author

Melero, I., Lakhani, N.J., Powderly, J., Adjei, A.A., Lopez, J.S., Paz-Ares, L.G., Moreno Candilejo, I., Thistlethwaite, F., Rohrberg, K.S., Jerusalem, G., Malmberg, A., Ioan-Facsinay, A., Upadhyay, P.J., Tan, B., Bartz, R., Gaziel, T.B.B., Forssmann, U., Celik, I., Gann, C., and De Mattos-Arruda, L.

Published
2024
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22. Examining teachers’ behavioural intention for online teaching after COVID-19 pandemic:a large-scale survey

Author

Khong, H. (Hang), Celik, I. (Ismail), Le, T. T. (Tinh T. T.), Lai, V. T. (Van Thi Thanh), Nguyen, A. (Andy), Bui, H. (Hong), Khong, H. (Hang), Celik, I. (Ismail), Le, T. T. (Tinh T. T.), Lai, V. T. (Van Thi Thanh), Nguyen, A. (Andy), and Bui, H. (Hong)

Abstract

Recently, the coronavirus disease 2019 (COVID-19) pandemic has led to rapid digitalisation in education, requiring educators to adopt several technologies simultaneously for online learning and teaching. Using a large-scale survey (N = 1740), this study aims to construct a model that predicts teachers’ extensive technology acceptance by extending the Technology Acceptance Model (TAM) with their technological pedagogical content knowledge (TPACK) and innovativeness. TAM has been a valuable tool to measure the adoption of new technology in various contexts, including education. However, TAM has been designed and principally applied to assess user acceptance of a specific technology implementation. This study has extended TAM to measure teachers’ technology-enabled practice (online teaching) with the adoption of various technologies. The proposed model explains teachers’ behavioural intention to teach online with a good fit. Our findings revealed the collective effects of TPACK, perceived usefulness (PU) of technology, and innovativeness on teachers’ behavioural intention to teach online post-pandemic. Moreover, the study identified training and support from school as a significant predictor for both teachers’ TPACK and PU. The novelty of this study lies in its model conceptualisation that incorporates both information-technology-based constructs and personal-competence-based features, including TPACK and innovativeness. Furthermore, our study contributes to the growing body of literature that addresses the online teaching adoption by schoolteachers in the post-pandemic era.

Published
2022

23. Response of learning analytics to the online education challenges during pandemic:opportunities and key examples in higher education

Author

Celik, I. (Ismail), Gedrimiene, E. (Egle), Silvola, A. (Anni), Muukkonen, H. (Hanni), Celik, I. (Ismail), Gedrimiene, E. (Egle), Silvola, A. (Anni), and Muukkonen, H. (Hanni)

Abstract

Emerging technological advancements can play an essential role in overcoming challenges caused by the COVID-19 pandemic. As a promising educational technology field, Learning Analytics (LA) tools or systems can offer solutions to COVID-19 pandemic-related needs, obstacles, and expectations in higher education. In the current study, we systematically reviewed 20 papers to better understand the responses of LA tools to the online learning challenges that higher education students, instructors, and institutions faced during the pandemic. In addition, we attempted to provide key cases in which LA has been effectively deployed for various purposes during the pandemic in the higher education context. We found out several prominent challenges for stakeholders. Accordingly, learners needed of timely support and interaction, and experienced difficulty of time management. Instructors lacked pedagogical knowledge for online teaching. In particular, individual and collaborative assessment have been a challenge for them. Institutions have not been ready for a digital transformation and online teaching. In response to these challenges, LA tools have been deployed for the following opportunities: monitoring, planning online learning process, fostering learners’ engagement and motivation, facilitating assessment process; increasing interaction, improving retention, being easy to use. Understanding these promises can also give insight into future higher education policies.

Published
2022

24. #NotHolidayButDistance education:a study on social media use for K-12 education during the COVID-19 pandemic

Author

Celik, I. (Ismail), Dindar, M. (Muhterem), Muukkonen, H. (Hanni), Celik, I. (Ismail), Dindar, M. (Muhterem), and Muukkonen, H. (Hanni)

Abstract

Purpose: This study aims to explore Twitter posts of Turkish government agencies and the public under a specific hashtag, #NotHolidayButDistanceEducation, specifically related to online distance education during the Covid-19 pandemic. Design/methodology/approach: This study used a thematic analysis on 22,547 original tweets posted by 6,970 users during the first month of online distance education in Turkish K-12 schools. Based on like and retweet counts, the study further explored the extent of stakeholders’ engagement with the observed themes. Findings: The findings showed that government agencies and citizens used Twitter to provide technical and psychological support, appreciate and motivate stakeholders, demonstrate sample distance education activities, share information and offer suggestions about the ongoing online distance education. It was also observed that the hashtag has been used for expressing negative views about online distance education and for political purposes. A positive relationship was found between social media engagement and providing technical support or sharing information for online distance education. Practical implications: This study highlights the role of social media in providing practical and emotional support to education stakeholders in times of crisis. Thus, governments can use social media to provide evidence-based psychological and physical health support to their citizens during a pandemic. Social media can serve to improve education practices in schools through the interactions between the public and policymakers. Originality/value: To the best of the authors’ knowledge, this study can be considered unique because it demonstrates the civic use of social media for educational crisis management. This study highlights the influence of social media in educational policy and practice development in the contemporary era.

Published
2022

25. The promises and challenges of artificial intelligence for teachers:a systematic review of research

Author

Celik, I. (Ismail), Dindar, M. (Muhterem), Muukkonen, H. (Hanni), Järvelä, S. (Sanna), Celik, I. (Ismail), Dindar, M. (Muhterem), Muukkonen, H. (Hanni), and Järvelä, S. (Sanna)

Abstract

This study provides an overview of research on teachers’ use of artificial intelligence (AI) applications and machine learning methods to analyze teachers’ data. Our analysis showed that AI offers teachers several opportunities for improved planning (e.g., by defining students’ needs and familiarizing teachers with such needs), implementation (e.g., through immediate feedback and teacher intervention), and assessment (e.g., through automated essay scoring) of their teaching. We also found that teachers have various roles in the development of AI technology. These roles include acting as models for training AI algorithms and participating in AI development by checking the accuracy of AI automated assessment systems. Our findings further underlined several challenges in AI implementation in teaching practice, which provide guidelines for developing the field.

Published
2022

26. Towards Intelligent-TPACK:an empirical study on teachers’ professional knowledge to ethically integrate artificial intelligence (AI)-based tools into education

Author

Celik, I. (Ismail) and Celik, I. (Ismail)

Abstract

The affordances of artificial intelligence (AI) have not been totally utilized in education. To effectively integrate AI into education, teachers’ AI-specific technological and pedagogical knowledge is important. Furthermore, due to novel ethical issues caused by Al, teachers also must have the knowledge to assess AI-based decisions. None of the previous studies so far explored teacher knowledge to pedagogically and ethically use AI-based tools. Considering this gap, we first developed a scale to measure the knowledge for instructional AI use based on the technological, pedagogical, and content knowledge (TPACK) framework. We extended TPACK with ethical aspects. Secondly, we built a model to investigate the interplay of TPACK components and ethics. The results indicated that as long as teachers have more knowledge to interact with AI-based tools, they will have a better understanding of the pedagogical contributions of AI. Further, technological knowledge (TK) allows teachers to better assess decisions of AI. However, only TK is not sufficient educational integration of AI-based tools. For teachers to deploy AI in education efficiently, TK is meaningful when it is combined with pedagogical knowledge (PK), reflected in technological pedagogical knowledge (TPK). Given pedagogical and technological affordances of AI-based tools, the current study suggests the Intelligent-TPACK framework.

Published
2022

28. Inhibition der Dihydroorotat-Dehydrogenase mit Leflunomid bzw. seinem aktiven Metaboliten A771726 führt zur Proliferationshemmung von Pankreaskarzinom-Zellen in vitro sowie zur Reduktion der Tumorvolumina im SCID-Maus-Modell in vivo

Author

Dietz, C., Becker, J. S., Hennig, S., Welter, V., Celik, I., Bartsch, D. K., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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29. Investigation of structural, electrical and tribological properties of duplex surface treated and aged Cu−Cr−Zr alloy.

Author

Celik, I. and Yuksel, O.

Subjects
*ELECTRICAL conductivity measurement, *DUPLEX stainless steel, *PHYSICAL vapor deposition, *COPPER, *SCANNING electron microscopes, *SURFACE properties
Abstract

In this study, Cu−Cr−Zr alloy specimens were first subjected to aging heat treatment at 500 °C for two different durations (2 hours and 4 hours). Three different coating processes (silver, silver/copper duplex, and copper/silver duplex) were applied to the aged specimens using the physical vapor deposition method. Tensile test, microhardness measurement, wear test, electrical conductivity measurement and structural analysis (x‐ray diffraction and scanning electron microscope) were applied to the specimens. After the aging processes, the highest hardness and strength values of the Cu−Cr−Zr alloy were obtained in the specimens that were aged at 500 °C for 4 hours. When the wear resistance and electrical conductivity of the coated specimens were examined, it was determined that the specimens with duplex surface treatment performed better. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Beta Elemene induces cytotoxic effects in FLT3 ITD-mutated acute myeloid leukemia by modulating apoptosis.

Author

ALAFNAN, A., DOGAN, R., BENDER, O., CELIK, I., MOLLICA, A., MALIK, J. A., RENGASAMY, K. R. R., BREAK, M. K. B., KHOJALI, W. M. A., ALHARBY, T. N., ATALAY, A., and ANWAR, S.

Abstract

OBJECTIVE: β-Elemene, a sesquiterpene with a broad anti-cancer spectrum, is particularly effective against drug-resistant and complex tumors. It can also be efficient against FLT3-expressed acute myeloid leukemia. This research aims to determine whether β-Elemene has cytotoxic effects on FLT3 ITD-mutated AML cells. MATERIALS AND METHODS: Cytotoxicity, cell morphology, mRNA analysis with apoptotic markers, and analysis of 43 distinct protein markers related to cell death, survival, and resistance were all performed to elucidate its mechanism. Additionally, in order to understand how β-Elemene and FLT3 interact, molecular docking, molecular dynamics simulations, and computational ADME investigations were performed. RESULTS: β-Elemene exhibited cytotoxic activity against FLT3-mutated MV4-11 and FLT3 wild-type THP-1 cells, with an IC50 of around 25 μg/ml. The molecular studies revealed that β-Elemene inhibited cell proliferation by inducing p53, and the involvement of p21, p27, HTRA, and HSPs were also demonstrated. The interactive inhibition in proliferation was confirmed via molecular docking and dynamics analyses. β-Elemene occupied the FLT3 enzymatic pocket with good stability at the FLT3 active site. CONCLUSIONS: We concluded from our observations that β-Elemene causes cell death in ITD mutant AML cells, together with the effects of stress factors and inhibiting cell division. [ABSTRACT FROM AUTHOR]

Published
2023

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