1,418 results on '"Celik, S."'
Search Results
2. The effect of core exercises on pain and quality of life in teenagers with primary dysmenorrhea complaints: Non-randomized controlled study
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Bağci Çelik, S., Ege, E., and Arslan, F.
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- 2024
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3. Refugee Education in Turkey: Barriers and Suggested Solutions
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Celik, S., Kardas Isler, N., and Saka, D.
- Abstract
Education is among the areas most affected by immigration. Addressing refugee children's schooling is an important contribution to the refugee crises, which span the world with far-reaching socio-economic effect. This study unpacks the challenges that refugee children, mainly from Syria, face in integrating into primary and secondary public schools in Turkey. It also proposes some tentative resolutions, drawing from the experiences of refugee parents, teachers, and headteachers. Within the current study, data were collected by means of fishbone analysis and semi-structured interviews with the participation of teachers, school headteachers, and refugee parents. The study draws from the theories of refugee education and confirms students' barriers in schooling with regard to psychosocial factors, cultural adaptation, language learning, systemic barriers, and family relations. Some further implications were elicited from the data and are discussed in line with the existing research.
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- 2023
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4. “A chain of interlocking rings”: Preschool teachers’ experiences regarding home-school collaboration with a focus on children with special needs and their parents in inclusive education
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Çelik, S. and Tomris, G.
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- 2024
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5. Could immune cells be associated with nephropathy in Fabry disease patients?
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Turkmen, K., Karaselek, M. A., Celik, S. C., Esen, H. H., Ozer, H., Baloglu, I., Ozturk, Y., Guner, S. N., Reisli, I., and Keles, S.
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- 2023
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6. Breast cancer with synchronous massive metastasis in uterine myoma: A case report and literature review
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Eroglu, S., primary, Celik, S., additional, Tatlidil, F., additional, Caliskan, C., additional, and Aydin, S.M., additional
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- 2024
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7. GnRH antagonist protocol with hCG triggering ameliorates fertilization defect caused by failure of cumulus cell pentraxin-3 expression in unilateral endometriomas.
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GUNGOR, N. D., CELIK, O., ERSAHIN, A., CELIK, N., KOBANER, M., YARDIM, M., DALKILIC, S., MELIL, S., CIL, K., CELIK, S., and AKKOC, R.
- Abstract
OBJECTIVE: The aim of the study was to determine the expression pattern of long pentraxin 3 (PTX3) mRNA in cumulus cells (CCs) isolated from metaphase II oocytes of women with unilateral endometrioma undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRHa) protocol. PATIENTS AND METHODS: A total of 60 CC samples, 30 from the affected ovary and 30 from the contralateral ovary, were collected from 12 patients with unilateral endometrioma who underwent flexible GnRHa protocol with recombinant human chorionic gonadotropin (rhCG) trigger. Thirty CC samples collected from the left ovary of 12 women with male factor infertility were used as external controls. Long PTX3 mRNA expression in each group was analyzed by real-time polymerase chain reaction (RT-PCR). Relative gene expression (fold-change) was calculated according to the 2-ΔΔCt equation. Fertilization rates after intracytoplasmic sperm injection (ICSI) were recorded for each group. RESULTS: CC-PTX3 mRNA expression in the unilateral endometrioma group was significantly lower than the mRNA expression of the disease-free ovary (0.90±0.01 vs. 0.25±0.02, p<0.01). CC-PTX3 mRNA expression of MII oocytes of the disease-free ovary was found to be similar to the control group (1.02±0.03 vs. 0.90±0.01, p=0.107). A significant 3.6-fold downregulation was observed in the CC-PTX3 mRNA expression of the endometrioma group compared to the CC-PTX3 mRNA expression in the contralateral ovary. CCPTX3 mRNA expression in the endometrioma group was downregulated 4.08-fold compared to the CC-PTX3 mRNA expression of the control group (1.02±0.03 vs. 0.25±0.02, p<0.001). The cumulus morphologies of the endometrioma group with low CC-PTX3 expression and the groups with normal CC-PTX3 levels were similar. Fertilization rates of the endometrioma group were similar to the contralateral ovary and control groups. CONCLUSIONS: Unilateral endometrioma reduces CC-PTX3 expression but does not affect disease-free ovaries. The GnRHa protocol improved the fertilization rates, suggesting that failed CCPTX3 expression is an in vivo pathology. [ABSTRACT FROM AUTHOR]
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- 2024
8. The COVID-19 pandemic: The evaluation of the emergency remote parent training program based on at-home support for children with down syndrome
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Çelik, S., Tomris, G., and Tuna, D.M.
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- 2022
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9. AB1293 FREQUENCY AND THE EFFECTS OF SPONDYLOARTHRITIS-SPECTRUM DISORDERS ON THE CLINICAL COURSE AND MANAGEMENT OF TAKAYASU ARTERITIS
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Abacar, K., primary, Kaymaz Tahra, S., additional, Bayindir, O., additional, Ince, B., additional, Kutu, M. E., additional, Yazici, A., additional, Durak Ediboglu, E., additional, Demirci Yildirim, T., additional, Ademoğlu, Z., additional, Omma, A., additional, Yasar Bilge, N. S., additional, Kimyon, G., additional, Kaşifoğlu, T., additional, Emmungil, H., additional, Onen, F., additional, Akar, S., additional, Cefle, A., additional, Kanitez, N. A., additional, Celik, S., additional, Inanc, M., additional, Aksu, K., additional, Keser, G., additional, Direskeneli, H., additional, and Alibaz-Oner, F., additional
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- 2024
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10. POS0933 THE FREQUENCY OF AORTIC AND MITRAL VALVE INVOLVEMENT IN PATIENTS WITH TAKAYASU ARTERITIS
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Kutu, M. E., primary, Tastekin, F., additional, Kerim, D., additional, Ocak, T., additional, San, S., additional, Yildirim, F., additional, Kocaayan, H., additional, Isik, S., additional, Kenar, G., additional, Avcu, A., additional, Uludogan, B. C., additional, Celik, S., additional, Aksu, K., additional, Keser, G., additional, Pehlivan, Y., additional, Cefle, A., additional, Yazici, A., additional, Bes, C., additional, Akar, S., additional, Omma, A., additional, Onen, F., additional, Direskeneli, H., additional, Alibaz- Oner, F., additional, Yasar Bilge, N. S., additional, and Kanitez, N. A., additional
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- 2024
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11. AB1328 IS THERE A NEED FOR ROUTINE IMAGING FOLLOW-UP IN PATIENTS WITH TAKAYASU ARTERITIS?
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Yildirim, F., primary, Bes, C., additional, Kutu, M. E., additional, Celik, S., additional, Tastekin, F., additional, Keser, G., additional, Ocak, T., additional, Dalkilic, E., additional, Pehlivan, Y., additional, Kocaayan, H., additional, Akar, S., additional, Isik, S., additional, Omma, A., additional, San, S., additional, Yazici, A., additional, Cefle, A., additional, Kenar, G., additional, Onen, F., additional, Avcu, A., additional, Alibaz- Oner, F., additional, Direskeneli, H., additional, Uludogan, B. C., additional, Yasar Bilge, N. S., additional, and Kanitez, N. A., additional
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- 2024
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12. Is thyroid function testing necessary in all cases of new onset atrial fibrillation diagnosed in the emergency department? - a real-life study
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Hytting, J, primary, Celik, S, additional, Bodestrom Eriksson, L, additional, Mallios, P, additional, Digerfeldt, C, additional, Waldemar, A, additional, Wijkman, M, additional, and Hubbert, L, additional
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- 2024
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13. Monogenic and Polygenic Contributions to Early Onset Advanced Heart Failure Based on Whole Genome Sequencing
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Linner, E., primary, Czuba, T., additional, Gidlöf, O., additional, Lundgren, J., additional, Bollano, E., additional, Hellberg, M., additional, Celik, S., additional, Pimpalwar, N., additional, Rentzsch, P., additional, Martorella, M., additional, Gummessson, A., additional, Melander, O., additional, Albinsson, S., additional, Dellgren, G., additional, Borén, J., additional, Jeppsson, A., additional, Lumbers, T., additional, Shah, S., additional, Nilsson, J., additional, Natarajan, P., additional, Lappalainen, T., additional, Levin, M., additional, Ehrencrona, H., additional, and Smith, J., additional
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- 2024
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14. The role of intermetallic particles on mode I crack propagation mechanisms in metal plates
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Tekog̃lu, C., Çelik, Ş., Duran, H., Efe, M., Baier-Stegmaier, S., and Nielsen, K.L.
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- 2021
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15. Monogenic and Polygenic Contributions to Early Onset Advanced Heart Failure Based on Whole Genome Sequencing
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Linner, E., Czuba, T., Gidlof, O., Lundgren, J., Bollano, E., Hellberg, M., Celik, S., Pimpalwar, N., Rentzsch, Philipp, Martorella, M., Gummessson, A., Melander, O., Albinsson, S., Dellgren, G., Boren, J., Jeppsson, A., Lumbers, T., Shah, S., Nilsson, J., Natarajan, P., Lappalainen, T., Levin, M., Ehrencrona, H., Smith, J., Linner, E., Czuba, T., Gidlof, O., Lundgren, J., Bollano, E., Hellberg, M., Celik, S., Pimpalwar, N., Rentzsch, Philipp, Martorella, M., Gummessson, A., Melander, O., Albinsson, S., Dellgren, G., Boren, J., Jeppsson, A., Lumbers, T., Shah, S., Nilsson, J., Natarajan, P., Lappalainen, T., Levin, M., Ehrencrona, H., and Smith, J.
- Abstract
QC 20240828
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- 2024
16. Unveiling complexity of hydrogen integration: A multi-faceted exploration of challenges in the Dutch context
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Hasankhani, M. (author), van Engelen, J.M.L. (author), Celik, S (author), Diehl, J.C. (author), Hasankhani, M. (author), van Engelen, J.M.L. (author), Celik, S (author), and Diehl, J.C. (author)
- Abstract
As the transition to sustainable energy intensifies, hydrogen emerges as a pivotal medium in mitigating climate change and improving energy security. While its applicability across various sectors is undeniable, its integration into established energy systems presents multifaceted challenges. This study investigates the complexities of integrating hydrogen into the Netherlands' energy systems. Beyond technological advancements, the successful design and rollout of a hydrogen supply chain require coordination and collaboration among a myriad of stakeholders. Through a mixed-methods approach, this study combines findings from a broad literature review, policy document analyses, evaluation of 59 field projects, and engaging dialogues with 33 key stakeholders from different sectors. This investigation led to the identification and categorization of key players in the Dutch hydrogen sector, revealing their interconnected roles and the challenges encountered in the hydrogen integration process. The study further categorized the identified challenges faced by stakeholders into five core domains: technical, infrastructural (including supply chain), socioeconomic, environmental, and institutional, with associated factors. Prominent challenges include transportation infrastructure upgrades, high initial costs and scalability, effective storage methods, safety and cybersecurity measures, storage and distribution infrastructure, security of supply, and public acceptance. This study contributes to the hydrogen integration discourse, offering insights for academics, industry, and policymakers. Its detailed stakeholder analysis, holistic categorization of challenges across five domains, and a stakeholder-centric approach grounded in real-world dialogues offer applicable frameworks beyond its primary context. In this vein, it guides future research and decisions, and its approach is adaptable for different regions or sectors, emphasizing comprehensive transition strategies., Design for Sustainability, Methodologie en Organisatie van Design
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- 2024
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17. Pool boiling heat transfer of ferrofluids on structured hydrophilic and hydrophobic surfaces: The effect of magnetic field
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Sadaghiani, A.K., Rajabnia, H., Çelik, S., Noh, H., Kwak, H.J., Nejatpour, M., Park, H.S., Acar, H.Y., Mısırlıoğlu, B., Özdemir, M.R., and Koşar, A.
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- 2020
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18. The effect of alpha blocker treatment prior to prostate biopsy on voiding functions, pain scores and health-related quality-of-life outcomes: A prospective randomized trial
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Sefik, E., Eker, A., Gunlusoy, B., Celik, S., Bozkurt, I.H., Basmaci, I., Polat, S., Degirmenci, T., and Ceylan, Y.
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- 2020
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19. Molecular Modeling, Dimer Calculations, Vibrational Spectra, and Molecular Docking Studies of 5-Chlorouracil
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Akalin, E., Celik, S., and Akyuz, S.
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- 2020
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20. IR laser line scanning treatments to improve levitation forces in MgTi0.06B2 bulk materials
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Ozturk, K., Aksoy, C., Angurel, L.A., Savaskan, B., Martínez, E., Badía-Majós, A., de la Fuente, G.F., Guner, B., Dancer, C.E.J., and Celik, S.
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- 2019
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21. An analysis on the relation between the seed distance and vertical levitation force for the multi−seeded YBCO using the modified advanced frozen image (MAFI) and experimental methods
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Ozturk, K., Guner, S.B., Abdioglu, M., Demirci, M., Celik, S., and Cansiz, A.
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- 2019
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22. Experimental Investigation of Crack Propagation Mechanisms in Commercially Pure Aluminium Plates
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Tekoğlu, C., Çelik, Ş., Duran, H., Efe, M., and Nielsen, K.L.
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- 2019
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23. Investigation of structural, superconducting and mechanical properties of Co/Cu substituted YBCO-358 ceramic composites
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Ozturk, O., Arebat, R. A. M., Nefrow, A. R. A., Bulut, F., Guducu, G., Asikuzun, E., and Celik, S.
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- 2019
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24. Improvement in levitation force performance of bulk MgB2 superconductors through coronene powder adding
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Erdem, O., Abdioglu, M., Guner, S.B., Celik, S., and Kucukomeroglu, T.
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- 2017
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25. The investigation on the regional nanoparticle Ag doping into MgTi0.06B2 bulk for improvement the magnetic levitation force and the bulk critical current
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Ozturk, K., Dancer, C.E.J., Savaskan, B., Aksoy, C., Guner, B., Badica, P., Aldica, G., and Celik, S.
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- 2017
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26. The dynamics of prehospital/hospital care and modes of transport during civil conflict and terrorist incidents
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Celik, S., Dursun, R., Aycan, A., Gönüllü, H., Adanaş, C., Eryılmaz, M., Gönüllü, E., Akyol, M.E., Keskin, S., and Güloğlu, C.
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- 2017
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27. Investigations of Archaeological Glass Bracelets and Perfume Bottles Excavated in Ancient Ainos (Enez) by Multiple Analytical Techniques
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Celik, S., Akyuz, T., Akyuz, S., Ozel, A. E., Kecel-Gunduz, S., and Basaran, S.
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- 2018
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28. Predictors of all-cause 30-days mortality in acute decompensated heart failure patients in the emergency department setting
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Bodestrom, L, primary, Celik, S, additional, Ftakas, D, additional, Digerfeldt, C, additional, and Hubbert, L, additional
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- 2023
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29. Troponin-T and age as predictors for mortality in patients with atrial fibrillation at the emergency department
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Celik, S, primary, Bodestrom Eriksson, L, additional, Waldemar, A, additional, Mallios, P, additional, Andersson, J, additional, Lunden, M, additional, Digerfeldt, C, additional, and Hubbert, L, additional
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- 2023
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30. We zijn er nog niet: De lange weg naar een inclusieve organisatie
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Brink, M.C.L. van den, Celik, S., Brink, M.C.L. van den, and Celik, S.
- Abstract
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- 2023
31. Emerging decentralized infrastructure networks
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Hasankhani, M. (author), van Engelen, J.M.L. (author), Celik, S (author), Diehl, J.C. (author), Hasankhani, M. (author), van Engelen, J.M.L. (author), Celik, S (author), and Diehl, J.C. (author)
- Abstract
Distributed hydrogen infrastructures have emerged as a complementary element in the quest for sustainable energy solutions, with potential applications in regions featuring high industrial demands and spatially resolved negative residual loads. These infrastructures can contribute to the decarbonization of electricity, heating, and transport sectors while enhancing local renewable energy consumption and supporting energy storage and demand-side management. However, their development presents unique design challenges, calling for a comprehensive understanding of stakeholder roles and relationships in the evolving ecosystem. This study examines stakeholder network dynamics within the distributed hydrogen ecosystem, focusing on the Netherlands' built environments. Through the analysis of 16 case studies, we employ Social Network Analysis (SNA) to identify and analyse stakeholder network involved in the early design and implementation of distributed hydrogen infrastructures. Our findings highlight emerging roles and interests due to the rise of such infrastructures, emphasizing the need for adaptable stakeholder relations. Design plays a critical role in this context, enabling stakeholders to navigate challenges, innovate, and foster collaboration. The paper explores stakeholder categories, providing insights into their interactions and coordination strategies. Ultimately, our study offers valuable guidance to practitioners and policymakers, promoting stakeholder collaboration for successful distributed hydrogen infrastructure deployment in pursuit of a sustainable, low-carbon energy future., Design for Sustainability, Methodologie en Organisatie van Design
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- 2023
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32. Environmental considerations in engineering: systemic differences between experts and novices
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Kirjavainen, Senni (author), Celik, S (author), Kirjavainen, Senni (author), and Celik, S (author)
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Engineering knowledge forms an essential part of our planetary fight against climate change. Traditionally, engineering curricula emphasizes the importance of technical knowledge and encourages to specialize in niche areas, where engineers develop themselves into experts. However, it is important to be able to reflect on complex societal challenges from a variety of perspectives to produce not only innovative, but also long-lasting and inclusive solutions for the greater good. This paper aims to understand the extent of systems thinking abilities of engineers by differentiating experts from novices. The study traces sustainability connections made by professional engineers and master's level engineering students when solving engineering design problems. This qualitative study highlights seven recurring themes that relate to the global sustainability discourse and describe a problem-centred approach through a real-life case that focuses on paper and pulp production, through a thematic analysis of 59 responses. The results portray system-level differences in how novice and expert engineers approach sustainability questions and how these differences shape their solution spaces., Methodologie en Organisatie van Design
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- 2023
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33. The size effect on the magnetic levitation force of MgB2 bulk superconductors
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Savaskan, B., Koparan, E.T., Güner, S.B., Celik, S., and Yanmaz, E.
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- 2016
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34. Utility of DN4 questionnaire in assessment of neuropathic pain and its clinical correlations in Turkish patients with diabetes mellitus
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Celik, S., Yenidunya, G., Temel, E., Purisa, S., Uzum, A. Kubat, Gul, N., Cinkil, G., Dinccag, N., and Satman, I.
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- 2016
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35. Comparative study of the magnetic stiffness, levitation and guidance force properties of single and multi seeded YBCOs for different HTS–PMG arrangements
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Ozturk, K., Sahin, E., Abdioglu, M., Kabaer, M., Celik, S., Yanmaz, E., and Kucukomeroglu, T.
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- 2015
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36. Lateral Position Effect of Auxiliary Permanent Magnets on the Magnetic Force Properties of Cylindrical YBCO
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Abdioglu, M., Kabaer, M., Ozturk, K., Erdem, O., and Celik, S.
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- 2017
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37. Kinetic field theory: perturbation theory beyond first order
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Pixius, C., primary, Celik, S., additional, and Bartelmann, M., additional
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- 2022
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38. Comprehensive Bio-Imaging Using Myocardial Perfusion Reserve Index During Cardiac Magnetic Resonance Imaging and High-Sensitive Troponin T for the Prediction of Outcomes in Heart Transplant Recipients
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Hofmann, N.P., Steuer, C., Voss, A., Erbel, C., Celik, S., Doesch, A., Ehlermann, P., Giannitsis, E., Buss, S.J., Katus, H.A., and Korosoglou, G.
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- 2014
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39. Are active surveillance criteria sufficient for predicting advanced stage prostate cancer patients?
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Ongun, S., Celik, S., Gül-Niflioglu, G., Aslan, G., Tuna, B., Mungan, U., Uner, S., and Yörükoğlu, K.
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- 2014
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40. Investigation on the levitation force behaviour of malic acid added bulk MgB2 superconductors
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Savaskan, B., Taylan Koparan, E., Celik, S., Ozturk, K., and Yanmaz, E.
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- 2014
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41. Treatment and outcomes of patients with metastatic spinal cord compression: a double-center study.
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AYCAN, A., EREN, B., TAS, A., CELIK, S., KARAGOZ GUZEY, F., KUYUMCU, F., AKYOL, M. E., SAGLAM, E., and AYCAN, N.
- Abstract
OBJECTIVE: Spinal metastases may only affect the bone tissue and result in spinal instability or may additionally result in epidural compression, leading to neurological deficits. Surgery has emerged as a popular method in treating metastatic epidural spinal cord compression (MESCC) due to the advances in surgical techniques and instrumentation. In this study, we evaluated patients with MESCC regarding neurological status, pain status, and survival rates, and presented our experience managing MESCC. PATIENTS AND METHODS: Clinical and radiographic records of 53 patients diagnosed with MESCC between January 2011 and March 2017 were retrospectively evaluated. The study included patients with a pathological diagnosis of primary cancer, those who complained of spinal metastasis, and those who had indications of MESCC on Magnetic Resonance Imaging (MRI). Bone structure and spinal stability were evaluated using assessed Computed Tomography (CT), and metastatic spread was considered using assessed Positron Emission Tomography (PET) in suitable cases. For each patient, the presence of a tumor compressing the spinal cord, age, gender, preoperative, and postoperative American Spinal Injury Association scores (ASIA), Tokuhashi prognostic score (TPS), affected spinal segment, pathological diagnosis, preoperative, and postoperative Visual Analog Scale (VAS), the status of spinal stability, follow-up period, and complications were evaluated. RESULTS: Forty-five patients (82.2% of them were women) underwent surgery with a mean age of 58.29 ± 15.14 years. The most frequent type of primary tumor was multiple myeloma (33.9%), followed by lung (24.6%), gastric (7.5%), and prostate (5.7%). The most common site of lowed by lumbar (24.5%), multiple (24.5%), and cervical (5.7%). The analysis indicated that a significant difference was found between the survival rates of the TPS categories. CONCLUSIONS: Common symptoms of MESCC include spinal pain and neurological deficit below the level of the injury. Prompt surgical treatment followed by oncological treatment leads to significant neurological recovery, more prolonged survival, pain relief, and improved quality of life in patients with a short survival time. Oncological treatments, including radiotherapy (RT), should be recommended after surgical treatment. [ABSTRACT FROM AUTHOR]
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- 2023
42. Celiac crisis in an adult type 1 diabetes mellitus patient presented with diarrhea, weight loss and hypoglycemic attacks
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Kizilgul, M., Kan, S., Celik, S., Apaydin, M., Ozcelik, O., Beysel, S., Cakal, E., Ozbek, M., Karaahmet, F., and Delibasi, T.
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- 2017
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43. Effect of hexagonal boron nitride on poly(vinyl phosphonic acid) composite polymer electrolytes for fuel cells
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Tutgun, M. S., Sinirlioglu, D., Celik, S. U., and Bozkurt, A.
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- 2016
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44. Effects of Bi-2212 addition on the levitation force properties of bulk MgB2 superconductors
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Taylan Koparan, E., Savaskan, B., Guner, S. B., and Celik, S.
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- 2016
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45. Mental health, quality of life, and COVID-19 fear in Turkish healthcare workers practicing in pandemic hospitals
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Sandal, A, primary, Karadogan, D, additional, Telatar, T G, additional, Kotan, A, additional, Konyalıhatipoğlu, E B, additional, Yumrukuz Senel, M, additional, Karadeniz Guven, D, additional, Huseynova, K, additional, Yalcin, B, additional, Asfuroglu, P, additional, Ramasli Gursoy, T, additional, Sismanlar Eyuboglu, T, additional, Karakas, F G, additional, Kose, N, additional, Kara, K, additional, Celik, S, additional, Ilgar, C, additional, Yuksel, A, additional, Guner Zirih, N M, additional, Selimoglu, I, additional, Yildiz, P, additional, Ercelik, M, additional, Cerit Cakir, A, additional, Cetin Beyaz, N, additional, Kaya, I, additional, Karaoglanoglu, S, additional, Marim, F, additional, Ozden Sertcelik, U, additional, Uyar Er, K, additional, Ozcelik, N, additional, Ataoglu, O, additional, Gultekin, O, additional, Er, A B, additional, and Akgun, M, additional
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- 2022
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46. Direct measurement of total antioxidant capacity of cereals: QUENCHER-CUPRAC method
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Tufan, Ayşe Nur, Çelik, S. Esin, Özyürek, Mustafa, Güçlü, Kubilay, and Apak, Reşat
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- 2013
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47. Ethical and medico-legal issues of TOETVA procedure and simulation on cadavers: a scoping review
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Oliva, Antonio, Grassi, S, Zedda, Massimo, Dionigi, G, Makay, O, Filograna, Laura, Cazzato, Francesca, De Crea, Carmela, Celik, S, Spagnolo, Antonio Gioacchino, Bellantone, Rocco Domenico Alfonso, Raffaelli, Marco, Oliva, A (ORCID:0000-0001-7120-616X), Zedda, M, Filograna, L, Cazzato, F, De Crea, C (ORCID:0000-0002-7303-9657), Spagnolo, A G (ORCID:0000-0002-5762-2164), Bellantone, R (ORCID:0000-0002-0844-3469), Raffaelli, M (ORCID:0000-0002-1259-2491), Oliva, Antonio, Grassi, S, Zedda, Massimo, Dionigi, G, Makay, O, Filograna, Laura, Cazzato, Francesca, De Crea, Carmela, Celik, S, Spagnolo, Antonio Gioacchino, Bellantone, Rocco Domenico Alfonso, Raffaelli, Marco, Oliva, A (ORCID:0000-0001-7120-616X), Zedda, M, Filograna, L, Cazzato, F, De Crea, C (ORCID:0000-0002-7303-9657), Spagnolo, A G (ORCID:0000-0002-5762-2164), Bellantone, R (ORCID:0000-0002-0844-3469), and Raffaelli, M (ORCID:0000-0002-1259-2491)
- Abstract
Conventional open thyroidectomy is still considered the gold standard for thyroid surgery. Transoral endoscopic thyroidectomy vestibular approach (also known as TOETVA) is often considered to be more advantageous than the other approaches, such as minimally invasive video assisted thyroidectomy, thyroidectomy via breast/axillary/retroauricular access, bilateral axillo-breast approach and axillo- bilateral breast approach. In this scoping review, we discuss the risks and the benefits of this surgical approach and its medico- legal and ethical implications, particularly focusing on the importance of practice on cadavers. Currently, there is little scientific evidence supporting TOETVA, since there are few papers on the comparison with the traditional open thyroidectomy that have been published and thus little data on the long-term outcomes of TOETVA are available. Since the better cosmetic outcome currently represents the main indication for this surgical technique, substantial medico- legal and ethical issues arise. Moreover, practice on cadavers can help surgeons to develop the technical and non-technical skills required to perform efficiently and safely this new surgical procedure.
- Published
- 2022
48. Design experiments for a development organisation in the Brazilian Amazon rainforest
- Author
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Mello Pereira Uriartt, S. (author), Celik, S (author), Lloyd, P.A. (author), Mello Pereira Uriartt, S. (author), Celik, S (author), and Lloyd, P.A. (author)
- Abstract
In the midst of climate change, and the need to seek more sustainable ways of living, design is increasingly tackling problems at a societal level. This paper reflects on a strategic design project at a Brazilian foundation focused on sustainable development in the Amazon rainforest region. In this study, we asked what contributions design can bring to organisations involved in addressing development issues. The paper describes several experiments and strategies to make it tangible to non-designers howa design-led process unfolds and how design can support the organisation's efforts in delivering value to the communities they serve. The case study offers an example on how design practices combined with systemic approaches can spark increasing levelsof collaboration across siloed departments, Methodologie en Organisatie van Design
- Published
- 2022
49. Body mass index and complications following major gastrointestinal surgery
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F, Shah R, Pickard J, Suleman YN, North AS, McClymont LF, Hussain N, Ibrahim I, Ng GS, Wong V, Lim AE, Harris LN, Tharmachandirar T, Mittapalli D, Patel V, Lakhani M, Bazeer HZ, Narwani V, Sandhu KK, Wingfield LR, Gentry S, Adjei H, Bhatti M, Braganza L, Barnes J, Mistry S, Chillarge G, Stokes S, Cleere J, Bucko AM, Meek J, Boxall N, Heywood EG, Wiltshire JJ, Toh C, Ward AE, Shurovi BN, Horth D, Patel BY, Ali B, Spencer T, Axelson T, Kretzmer L, Chhina C, Anandarajah C, Fautz T, Horst C, Thevathasan AA, Ng JQ, Hirst F, Brewer CF, Logan AE, Lockey JW, Forrest PR, Keelty N, Wood AD, Springford LR, Avery P, Schulz TM, Bemand TP, Howells L, Collier H, Khajuria A, Tharakan RG, Parsons S, Buchan AM, McGalliard RJ, Mason JD, Cundy OJ, Li N, Redgrave NA, Watson RP, Pezas TP, Dennis YF, Segall E, Hameed M, Lynch AS, Chamberlain M, Peck FS, Neo YN, Russell G, Elseedawy M, Foster NL, Soo YH, Puan L, Dennis R, Goradia H, Qureshi A, Osman S, Reeves T, Dinsmore L, Marsden M, Lu Q, Pitts-Tucker T, Dunn CE, Walford RA, Heathcote E, Martin R, Pericleous A, Brzyska K, Reid KG, Williams MR, Wetherall N, McAleer E, Thomas D, Kiff R, Milne S, Holmes MJV, Bartlett J, Lucas de Carvalho J, Bloomfield T, Tongo F, Bremner RH, Yong N, Atraszkiewicz BA, Mehdi A, Tahir M, Sherliker GXJ, Tear AK, Pandey A, Broyd A, Omer HM, Raphael M, Chaudhry WW, Shahidi S, Jawad AS, Gill CK, Hindle Fisher I, Adeleja I, Clark IJ, Aidoo-Micah GE, Stather PW, Salam GJ, Glover TE, Deas G, Sim NK, Obute RD, Wynell-Mayow WM, Sait MS, Mitha N, de Bernier GL, Siddiqui M, Shaunak R, Wali A, Cuthbert G, Bhudia R, Webb E, Shah S, Ansari N, Perera M, Kelly N, McAllister R, Stanley GH, Keane CP, Shatkar V, Maxwell-Armstrong C, Henderson LA, Maple N, Manson R, Adams RD, Semple E, Mills M, Daoub A, Marsh A, Ramnarine A, Hartley J, Malaj M, Jewell PD, Whatling EA, Hitchen N, Chen M, Goh B, Fern J, Rogers S, Derbyshire L, Robertson DT, Deekonda P, Abid A, Harrison PLM, Aildasani L, Turley H, Sherif MA, Pandey G, Filby JJ, Johnston A, Burke E, Mohamud M, Gohil K, Tsui AY, Singh R, Lim SJ, O'Sullivan K, McKelvey LL, O'Neill S, Roberts HF, Brown FS, Cao Y, Buckle RT, Liew Y, Sii S, Ventre CM, Graham CJ, Filipescu T, Yousif A, Dawar R, Wright A, Peters M, Varley R, Owczarek S, Hartley S, Khattak M, Iqbal A, Ali M, Durrani B, Narang Y, Bethell GS, Horne L, Pinto R, Nicholls K, Kisyov I, Torrance HD, English W, Lakhani SM, Ashraf SF, Venn M, Elangovan V, Kazmi Z, Brecher J, Sukumar S, Mastan A, Mortimer A, Parker J, Boyle J, Elkawafi M, Beckett J, Mohite A, Narain A, Mazumdar E, Sreh A, Hague A, Weinberg D, Fletcher L, Steel M, Shufflebotham H, Masood M, Sinha Y, Jenvey C, Kitt H, Slade R, Craig AR, Deall C, Reakes T, Chervenkoff J, Strange E, O'Bryan M, Murkin C, Joshi D, Bergara T, Naqib S, Wylam D, Scotcher SE, Hewitt CM, Stoddart MT, Kerai A, Trist AJ, Cole SJ, Knight CL, Stevens S, Cooper GE, Ingham R, Dobson J, O'Kane A, Moradzadeh J, Duffy A, Henderson C, Ashraf S, McLaughin C, Hoskins TC, Reehal RS, Bookless LR, McLean RC, Stone EJ, Wright EV, Abdikadir HR, Roberts C, Spence O, Srikantharajah M, Ruiz EM, Matthews JH, Gardner E, Hester E, Naran P, Simpson R, Minhas M, Cornish E, Semnani SA, Rojoa D, Radotra A, Eraifej J, Eparh K, Smith DNE, Mistry BD, Hickling SL, Din W, Liu C, Mithrakumar P, Mirdavoudi V, Rashid M, Mcgenity C, Hussain O, Kadicheeni M, Gardner H, Anim-Addo N, Pearce J, Aslanyan A, Ntala C, Sorah T, Parkin J, Alizadeh M, White A, Edozie F, Johnston J, Kahar A, Navayogaarajah V, Carter D, Khonsari P, Burgess A, Patel B, Kong C, Ponweera A, Cody A, Tan Y, Ng AYL, Croall A, Allan C, Ng S, Raghuvir V, Telfer R, Greenhalgh AD, McKerr CN, Edison MA, Patel BA, Dear K, Hardy MR, Williams P, Hassan S, Sajjad U, O'Neill EM, Lopes S, Healy L, Jamal N, Tan S, Lazenby D, Husnoo SB, Beecroft S, Sarvanandan T, Weston C, Bassam N, Rabinthiran S, Hayat U, Ng L, Varma D, Sukkari M, Mian A, Omar A, Kim JW, Sellathurai J, Mahmood J, O'Connell C, Bose R, Heneghan H, Lalor P, Matheson J, Doherty C, Cullen C, Cooper D, Angelov S, Drislane C, Smith ACD, Kreibich A, Palkhi E, Durr A, Lotfallah A, Gold D, Mckean E, Dhanji A, Anilkumar A, Thacoor A, Siddiqui ZH, Lim S, Piquet A, Anderson SM, McCormack DR, Gulati J, Ibrahim A, Murray SE, Walsh SL, McGrath A, Ziprin P, Chua EY, Lou CN, Bloomer J, Paine HR, Osei-Kuffour D, White CJ, Szczap A, Gokani S, Patel K, Malys MK, Reed A, Torlot GE, Cumber EM, Charania A, Ahmad S, Varma N, Cheema H, Austreng L, Petra H, Chaudhary M, Zegeye MI, Cheung F, Coffey D, Heer RS, Singh S, Seager E, Cumming S, Suresh RS, Verma S, Ptacek IB, Gwozdz AM, Yang T, Khetarpal AA, Shumon S, Fung TMP, Leung W, Kwang P, Chew L, Loke W, Curran A, Chan C, McGarrigle C, Mohan K, Cullen S, Wong E, Toale C, Collins D, Keane N, Traynor BP, Shanahan D, Yan A, Jafree DJ, Topham C, Mitrasinovic S, Omara S, Bingham G, Lykoudis PM, Miranda BH, Whitehurst K, Kumaran G, Devabalan Y, Aziz H, Shoa M, Dindyal S, Yates JA, Bernstein I, Rattan G, Coulson R, Stezaker S, Isaac A, Salem M, McBride A, McFarlane H, Yow L, MacDonald J, Bartlett RD, Turaga S, White U, Liew W, Yim N, Ang A, Simpson A, McAuley D, Craig E, Murphy L, Shepherd P, Kee JY, Abdulmajid A, Chung A, Warwick HL, Livesey A, Holton P, Theodoreson MD, Jenkin SL, Turner J, Entwisle JH, Marchal ST, O'Connor S, Blege HK, Aithie JM, Sabine LM, Stewart GE, Jackson S, Kishore A, Lankage CM, Acquaah F, Joyce HL, McKevitt KL, Coffey CJ, Fawaz AS, Dolbec KS, O'Sullivan DA, Geraghty JM, Lim E, Bolton L, FitzPatrick D, Robinson C, Ramtoola T, Collinson S, Grundy L, McEnhill PM, Harbhajan Singh GS, Loughran D, Golding DM, Keeling RE, Williams RP, Whitham RDJ, Yoganathan S, Nachiappan R, Egan RJ, Owasil R, Kwan ML, He A, Goh RW, Bhome R, Wilson H, Teoh PJ, Raji K, Jayakody N, Matthams J, Chong J, Luk CY, Greig RJ, Trail M, Charalambous G, Rocke AS, Gardiner N, Bulley F, Warren N, Brennan E, Fergurson P, Wilson R, Whittingham H, Brown EJ, Khanijau R, Gandhi K, Morris S, Boulton AJ, Chandan N, Barthorpe AE, Maamari R, Sandhu S, McCann M, Higgs L, Balian V, Reeder C, Diaper C, Sale T, Ali H, Archer CH, Clarke AK, Heskin J, Hurst PC, Farmer JD, O'Flynn LD, Doan L, Shuker BA, Stott GD, Vithanage NA, Hoban KA, Nesargikar PN, Kennedy HR, Grossart CM, Tan ESM, Roy CSD, Sim P, Leslie KE, Sim D, Abul MH, Cody N, Tay AY, Woon E, Sng S, Mah J, Robson J, Shakweh E, Wing VC, Mills H, Li MM, Barrow TR, Balaji S, Jordan HEM, Phillips C, Naveed H, Hirani S, Tai A, Ratnakumaran R, Sahathevan A, Shafi AMA, Seedat M, Weaver R, Batho A, Punj R, Selvachandran H, Bhatt N, Botchey S, Khonat Z, Brennan K, Morrison CJ, Devlin E, Linton A, Galloway E, McGarvie S, Ramsay N, McRobbie HD, Whewell H, Dean W, Nelaj S, Eragat M, Mishra A, Kane T, Zuhair M, Wells M, Wilkinson D, Woodcock N, Sun E, Aziz N, Abd Ghaffar MK, Bath MF, Nepogodiev D., Blanco-Colino, R, Lee, S, Kamarajah, Sk, Vasko, P, Kuiper, Sz, Farina, V, Chapman, Sj, Drake, Tm, Gavagna, L, Pasquali, S, Pata, F, Pellino, G, de la Rosa-Estadella, M, Stellingwerf, Me, Stijns, Rch, Borrellas, A, Golding, D, Ngaage, M, Van Tol, Rr, de Groof, J, de Wilt, H, Bemelman, Wa, Mcnamee, L, Espin-Basany, E, Emre Baki, B, Gecim, Ie, Can Tatar, O, Bach, S, Bhangu, A, Bresges, K, Burke, J, Claireaux, Ha, Fearnhead, N, Fitzgerald, Je, Gallagher, S, Glasbey, Jc, Gundogan, B, Harrison, Em, Hernon, J, Khatri, C, Kong, Cy, Lyons, A, Mohan, M, Morton, D, Pinkney, Td, Arezzo, A, Foppa, C, Morino, M, Rubbini, M, Selvaggi, F, Sensi, B, Sica, G, Orhalmi, J, Naccari, P, Sgrò, A, Burger, Bhcm, Fares, Da, Spijkerman, R, van Elst, Tr, Wiersema, R, Stassen, Lp, Rodriguez Garcia, R, Özkan, Bb, Tavuz, Ai, Demirci, Z, Baki, Be, Choi, Pj, O'Sullivan, H, Salman, M, Simioni, A, Colombo, F, Turati, L, Cazzola, Fe, Gallo, G, Perrotta, G, Papandrea, M, Naccari, Pm, Menduni, N, Rossi, E, Chetta, N, Romeo, F, Giordano, F, Randisi, B, Curletti, G, Kuiper, J, Costa, A, Marcos Rodrigo, A, Sanchez, A, Varo Muñoz, A, Martinez Rios, Ce, Aliseda-Jover, D, Fernandez Nieto, D, Alvarez Reyes, I, Dominguez Rodriguez, Lm, Hernandez Ros, Mi, Esteban Sinovas, O, Bartrina Soler, P, Villarejo Campos, P, Laguna Román, S, Fontanet-Soler, S, Raurich-Leandro, J, Dominguez-Prieto, V, Segura-Sampedro, Jj, Alconchel-Gago, F, Salazar-García, C, Gezen, Ae, Sahin, A, Atasoy, H, Yuksek, B, Arslan, E, Ozmen, Bb, Sen, Ay, Erol, Hi, Ucar, E, Aktas, Mk, Yurdaor, S, Mermer, S, Seyhan, U, Tosun, V, Gunaydin, Y, Ekinci, Zb, Yazkan, Z, Choi, J, Yeoh, Tsl, Jones, C, Venturini, S, Saat, Mi, Loo, J, Pike, G, Davies, Sc, Kabariti, R, Olivier, J, Hurný, M, Žebrák, R, Machačová, A, Schulzová, M, Smolák, P, Široká, M, Palyzová, H, Jaroš, J, Dušek, T, Šimáčková, B, Bartoš, M, Sotona, O, Pös, M, Karásek, D, Higgins, P, Hacking, S, Arora, E, Coughlan, G, Palanivail, N, Quill, S, Zhang, Aa, Malak, M, Maan, D, Cheema, J, Goh, Awj, Shamsul Badrin, Ak, Guinness, F, Howard James, N, Neary, A, Sebaoui, S, Gilroy, D, Petrov, G, Craven, K, Macdonald, A, Redmond, A, Brennan, D, Roche, D, O'Dwyer, M, 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Puccioni, C, Truma, A, Giardino, Fr, Giuffrida, A, Ripa, M, Cautiero, R, Patturelli, M, Capozzolo, A, Selvaggi, L, Facchiano, A, Milazzo, Lf, Papazachariou, Sk, Pattapola, V, Anania, G, Feo, C, Bellinato, M, Priani, P, Zigiotto, D, Troia, A, Vable, T, Piran, G, Targa, S, Pulpito, S, Tagariello, F, Fasano, A, Anconelli, D, Castiglione, F, Tognolo, L, Lopez, G, Campion, A, Tarantino, M, Sacco, R, Sammarco, G, Palmisano, S, Giacca, M, Rocco, I, Bellio, G, Favero, A, Raimondi, P, Pantalone, Mr, De Nardi, P, Notarnicola, M, Picciariello, A, Licari, L, Parinisi, Z, Fazzotta, S, Ciciliot, M, Reggiani, L, Mariani, F, Aonzo, P, Checcacci, P, Montanelli, P, Guerra, F, Skalamera, I, Staderini, F, Grandi, S, Nelli, T, de Boer, Dv, van der Pool, Aem, Janssen, Tl, El-Atmani, S, van Verschuer, Vmt, Poelman, M, Dronkers, Wj, van Steensel, L, Toorenvliet, Br, Duinhouwer, Le, Vermaas, M, Ter Bruggen, Ffja, Hogendoorn, W, van der Harst, E, van Rijckevorsel, Vajim, Bayoumy, Ab, Lap, Cr, Gooszen, Jah, Abdulrahman, N, de Roy van Zuidewijn, D, de Groof, Ej, Zijlmans, Jl, van Dalen, Ashm, Bos, K, Musters, Gd, Looijen, Rc, Fliers, Jm, Oostendorp, Se, Mosterd, Cm, Blonk, L, Jurgens, J, Ribbink, Me, Boom, M, Boersma, Am, Hidding, E, Schmidt, Pa, Mensink, G, Graus, Sa, Gastel, Mda, Veenker, Cgh, Van Heumen, Tm, Slieker, Fjb, Sedee, Wja, Löwensteyn, Yn, Amelung, Fj, de Guerre, Levm, Nota, Clma, Van Dijck, Wpm, van Wijnbergen, Jwm, Pronk, A, Kip, M, van der Zee, C, Heiloo, S, Muller, S, Verboeket, B, Oudman, T, Zope, S, Gilissen, V, Gommers, J, Cremers, D, Van der Lubbe, M, Smet, M, Ter Weele, K, de Bruin, M, Geerlings, M, Ter Horst, L, Kerimova, N, Pesser, N, Heesakkers, H, de Mees, T, de Gooyer, Jm, Willems, L, Gawria, L, Bonouvrie, D, Harms, J, Eggen, Y, Hengeveld, E, Smeets, Hj, Hoffman, Rpc, Detmers Blom, Fpn, Van Bruggen, D, Steup, Wh, Gooiker, Ga, Willems, Yr, van der Hoeven, Ac, Vallve-Bernal, M, Perez-Gandara, B, Perez, Jl, Caballero Rodriguez, E, Perez Febles, M, Protti Ruiz, Gp, Hidalgo Pujol, M, Alberti Delgado, P, Gil Barrionuevo, E, Anabitarte, O, Caballero, L, Poyato Nuñez, Fj, Prado Perez, R, de la Portilla de Juan, F, Fulgencio Barbarin, J, Elorza Echaniz, G, Mitxelena Elosegi, L, Delgado, At, Marti Gelonch, L, Gonzalez Arribas, M, De Serra Tejada, I, Alberdi San Roman, I, de Andres Olabarria, U, Fernández-Domper, L, Perez Costoya, C, Perez Arias, H, Fa Binefa, M, Becerra Nieves, M, Escalona Canal, Mg, Aldrey, I, Vazquez-Gonzalez, I, Falcon Cazas, A, Amarelo Garcia, M, Gonzalez Ruiz, Aa, Garcia Garrido, M, Simon Frapolli, V, Martinez Diaz, Jm, De la Torre Conde, C, Rodrigues Silva, K, Hernandez Kakauridze, S, Lopez Garcia, Mc, Flores Funes, D, Gómez-López de San Román, C, San Martín Bragado, M, Tejero Pintor, Fj, Pando Ruiz, B, Sánchez Estébanez, E, Roquet Puigneró, E, Pla Seró, S, Vela Polanco, Ff, Mirallas Viñas, O, Caro Gonzalez, Mp, Bertelli Puche, Jl, Gonzalez-Martinez, A, Sanchez Cambronero, M, Garcia Torres, A, Dominguez Jimenez, M, de Jesus 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Nachiappan R, Egan RJ, Owasil R, Kwan ML, He A, Goh RW, Bhome R, Wilson H, Teoh PJ, Raji K, Jayakody N, Matthams J, Chong J, Luk CY, Greig RJ, Trail M, Charalambous G, Rocke AS, Gardiner N, Bulley F, Warren N, Brennan E, Fergurson P, Wilson R, Whittingham H, Brown EJ, Khanijau R, Gandhi K, Morris S, Boulton AJ, Chandan N, Barthorpe AE, Maamari R, Sandhu S, McCann M, Higgs L, Balian V, Reeder C, Diaper C, Sale T, Ali H, Archer CH, Clarke AK, Heskin J, Hurst PC, Farmer JD, O'Flynn LD, Doan L, Shuker BA, Stott GD, Vithanage NA, Hoban KA, Nesargikar PN, Kennedy HR, Grossart CM, Tan ESM, Roy CSD, Sim P, Leslie KE, Sim D, Abul MH, Cody N, Tay AY, Woon E, Sng S, Mah J, Robson J, Shakweh E, Wing VC, Mills H, Li MM, Barrow TR, Balaji S, Jordan HEM, Phillips C, Naveed H, Hirani S, Tai A, Ratnakumaran R, Sahathevan A, Shafi AMA, Seedat M, Weaver R, Batho A, Punj R, Selvachandran H, Bhatt N, Botchey S, Khonat Z, Brennan K, Morrison CJ, Devlin E, Linton A, Galloway E, McGarvie S, Ramsay N, McRobbie HD, Whewell H, Dean W, Nelaj S, Eragat M, Mishra A, Kane T, Zuhair M, Wells M, Wilkinson D, Woodcock N, Sun E, Aziz N, Abd Ghaffar MK., Nepogodiev, Dmitri, Rosati, Riccardo, Nepogodiev, D., and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
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Male ,obesity ,Multivariate analysis ,Gastrointestinal Diseases ,IMPACT ,Settore MED/18 - CHIRURGIA GENERALE ,Body mass index ,Body weight ,Digestive tract ,Gastrointestinal tract ,Obesity ,Postoperative complications ,Gastroenterology ,digestive tract ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Risk Factors ,Medicine ,Prospective Studies ,Prospective cohort study ,Aged ,Europe ,Female ,Gastrointestinal Neoplasms ,Humans ,Middle Aged ,Postoperative Complications ,Body Mass Index ,OUTCOMES ,body mass index ,body weight ,gastrointestinal tract ,030220 oncology & carcinogenesis ,Meta-analysis ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Cohort ,030211 gastroenterology & hepatology ,Cohort study ,medicine.medical_specialty ,Malignancy ,NO ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,business.industry ,postoperative complications ,MORTALITY ,medicine.disease ,Settore MED/18 ,Surgery ,Postoperative complication ,Postoperative Complications, Obesity, Digestive Tract, Gastrointestinal Tract, Body Mass Index, Body Weight ,business - Abstract
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
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- 2018
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50. Does intestinal obstruction influence hypo-albuminemia: assessment of the physio-pathogenesis of protein-losing enteropathy with literature review.
- Author
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BAKKALOGLU, O. K., BAVUNOGLU, I., ASLAN, S., ESKAZAN, T., CELIK, S., KEPIL, N., HATEMI, I., ERZIN, Y., and CELIK, A. F.
- Abstract
BACKGROUND: Non-steroidal anti-inflammatory drug (NSAID) use may cause diaphragm-like lesions in the bowel. Although NSAID-enteropathy is among the causes of protein-losing enteropathy (PLE), intractable hypoalbuminemia is rare. CASE REPORT: Here, we discuss a case of NSAID-enteropathy with a diaphragm-like disease that presented with Protein Losing Enteropathy (PLE) rather than obstruction. The hypoalbuminemia recovered immediately after resection of the obstructive segment, despite ongoing annular ulcerations in the early postoperative period. Thus, it was not clear whether obstructive mechanisms influenced resistant hypoalbuminemia besides the ulcers. We also reviewed the English-written literature for “diaphragm-type lesion, NSAID-enteropathy, obstruction, and protein-losing enteropathy”. We noted that the role of obstruction in the pathophysiology of PLE was not clear. CONCLUSIONS: As our case and a couple of cases reported in literature, slow-onset obstructive pathology seems to contribute to well-known factors: inflammatory response, exudation, tight-junction dysfunction, and increase in permeability in the physiopathology of NSAID-induced PLE. Factors such as distention-induced low-flow ischemia and reperfusion, cholecystectomy-related continuous bile flow, bacterial overgrowth-related bile deconjugation and concomitant inflammation are among other potential influencers. The possible role of a slow-onset obstructive pathology in the physiopathology of NSAID-induced and other PLE needs to be further elucidated. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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