1. Association of dietary intake and serum concentration of omega-3 fatty acids on celiac disease: evidence from observational study and Mendelian randomization.
- Author
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Bai T, Peng J, and Wu C
- Subjects
- Humans, Cross-Sectional Studies, Female, Male, Adult, Middle Aged, Risk Factors, Diet, Young Adult, Biomarkers blood, Polymorphism, Single Nucleotide, United States epidemiology, Aged, Celiac Disease blood, Celiac Disease diet therapy, Celiac Disease genetics, Mendelian Randomization Analysis, Fatty Acids, Omega-3 blood, Nutrition Surveys
- Abstract
Objective: The association between omega-3 fatty acids (O3FA) and celiac disease lacks sufficient investigation., Methods: Utilizing data gleaned from the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES), this research comprises a sample of 13 403 adults, each aged 20 years and above. We conducted a multivariable logistic regression analysis to assess the association between dietary intake of O3FA and celiac disease. Subsequently, a two-sample Mendelian randomization was performed to estimate the unconfounded causal relationship between serum O3FA and celiac disease. The principal analytical strategy utilized the inverse-variance weighted methodology., Results: In this cross-sectional study, 48 occurrences (0.36%) of celiac disease were encompassed. In the multivariable model, there was no association between dietary intake of O3FA and cases of celiac disease (odds ratio: 1.12, 95% confidence interval: 0.47-2.66, P = 0.792). However, serum levels of O3FA determined by genetic assay were correlated with celiac disease (inverse-variance weighted, β = 0.2439, P = 0.0287), with no evidence of horizontal pleiotropy ( P = 0.3689)., Conclusion: The dietary consumption of O3FA did not exhibit an association with the risk of celiac disease in this cross-sectional investigation. However, a correlation between celiac disease and serum levels of O3FA was observed in the Mendelian randomization. Further investigations, including human clinical trials, are warranted., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
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