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39 results on '"Celesti, Consuelo"'

8. Modified Gold Screen-Printed Electrodes for the Determination of Heavy Metals.

Author

Celesti, Consuelo, Giofrè, Salvatore Vincenzo, Espro, Claudia, Legnani, Laura, Neri, Giovanni, and Iannazzo, Daniela

Subjects
*GOLD electrodes, *HEAVY metals, *METAL detectors, *METAL ions, *SQUARE waves
Abstract

Screen-printed electrodes (SPEs) are reliable, portable, affordable, and versatile electrochemical platforms for the real-time analytical monitoring of emerging analytes in the environmental, clinical, and agricultural fields. The aim of this study was to evaluate the electrochemical behavior of gold screen-printed electrodes (SPGEs) modified with molecules containing amino (Tr-N) or α-aminophosphonate (Tr-P) groups for the selective and sensitive detection of the toxic metal ions Pb2+ and Hg2+ in aqueous samples. After optimizing the analytical parameters (conditioning potential and time, deposition potential and time, pH and concentration of the supporting electrolyte), anodic square wave stripping voltammetry (SWASV) was used to evaluate and compare the electrochemical performance of bare or modified electrodes for the detection of Hg2+ and Pb2+, either alone or in their mixtures in the concentration range between 1 nM and 10 nM. A significative improvement in the detection ability of Pb2+ ions was recorded for the amino-functionalized gold sensor SPGE-N, while the presence of a phosphonate moiety in SPGE-P led to greater sensitivity towards Hg2+ ions. The developed sensors allow the detection of Pb2+ and Hg2+ with a limit of detection (LOD) of 0.41 nM and 35 pM, respectively, below the legal limits for these heavy metal ions in drinking water or food, while the sensitivity was 5.84 µA nM−1cm−2 and 10 µA nM−1cm−2, respectively, for Pb2+ and Hg2+. The reported results are promising for the development of advanced devices for the in situ and cost-effective monitoring of heavy metals, even in trace amounts, in water resources. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Solid Lipid Nanoparticles Containing Morin: Preparation, Characterization, and Ex Vivo Permeation Studies

Author

De Gaetano, Federica, primary, Celesti, Consuelo, additional, Paladini, Giuseppe, additional, Venuti, Valentina, additional, Cristiano, Maria Chiara, additional, Paolino, Donatella, additional, Iannazzo, Daniela, additional, Strano, Vincenza, additional, Gueli, Anna M., additional, Tommasini, Silvana, additional, Ventura, Cinzia Anna, additional, and Stancanelli, Rosanna, additional

Published
2023
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16. Promising Materials in the Fight against Healthcare-Associated Infections: Antibacterial Properties of Chitosan-Polyhedral Oligomeric Silsesquioxanes Hybrid Hydrogels.

Author

Laganà, Antonio, Facciolà, Alessio, Iannazzo, Daniela, Celesti, Consuelo, Polimeni, Evelina, Biondo, Carmelo, Di Pietro, Angela, and Visalli, Giuseppa

Subjects
RHEOLOGY, DRUG resistance in bacteria, BIOMEDICAL materials, SURFACE charges, CONFOCAL microscopy, GRAM-positive bacteria, SILICONES
Abstract

New technologies and materials could help in this fight against healthcare-associated infections. As the majority of these infections are caused by antibiotic-resistant bacteria, the development of materials with intrinsic antibacterial properties is a promising field of research. We combined chitosan (CS), with antibacterial properties, with polyhedral oligomeric silsesquioxanes (POSS), a biocompatible polymer with physico-chemical, mechanical, and rheological properties, creating a hydrogel using cross-linking agent genipin. The antibacterial properties of CS and CS-POSS hydrogels were investigated against nosocomial Gram-positive and Gram-negative bacteria both in terms of membrane damage and surface charge variations, and finally, the anti-biofilm property was studied through confocal microscopy. Both materials showed a good antibacterial capacity against all analyzed strains, both in suspension, with % decreases between 36.36 and 73.58 for CS and 29.86 and 66.04 for CS-POSS, and in plates with % decreases between 55.29 and 78.32 and 17.00 and 53.99 for CS and CS-POSS, respectively. The treated strains compared to the baseline condition showed an important membrane damage, which also determined a variation of surface charges, and finally, for both hydrogels, a remarkable anti-biofilm property was highlighted. Our findings showed a possible future use of these biocompatible materials in the manufacture of medical and surgical devices with intrinsic antibacterial and anti-biofilm properties. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Chitosan/POSS Hybrid Hydrogels for Bone Tissue Engineering

Author

Celesti, Consuelo, primary, Iannazzo, Daniela, additional, Espro, Claudia, additional, Visco, Annamaria, additional, Legnani, Laura, additional, Veltri, Lucia, additional, Visalli, Giuseppa, additional, Di Pietro, Angela, additional, Bottino, Paola, additional, and Chiacchio, Maria Assunta, additional

Published
2022
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19. Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy

Author

Iannazzo, Daniela, primary, Celesti, Consuelo, additional, Espro, Claudia, additional, Ferlazzo, Angelo, additional, Giofrè, Salvatore V., additional, Scuderi, Mario, additional, Scalese, Silvia, additional, Gabriele, Bartolo, additional, Mancuso, Raffaella, additional, Ziccarelli, Ida, additional, Visalli, Giuseppa, additional, and Di Pietro, Angela, additional

Published
2022
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28. Sterile inflammation induced by respirable micro and nano polystyrene particles in the pathogenesis of pulmonary diseases

Author

Antonio, Laganà, Visalli, Giuseppa, Facciolà, Alessio, Saija, Caterina, Bertuccio, Maria Paola, Baluce, Barbara, Celesti, Consuelo, Iannazzo, Daniela, and Di Pietro, Angela

Abstract

Sterile inflammation is involved in the lung pathogenesis induced by respirable particles, including micro- and nanoplastics. Their increasing amounts in the ambient and in indoor air pose a risk to human health.In two human cell lines (A549 and THP-1) we assessed the proinflammatory behavior of polystyrene nanoplastics (nPS) and microplastics (mPS) (Ø 0.1 and 1 μm). Reproducing environmental aging, in addition to virgin, the cells were exposed to oxidized nPS/mPS. To study the response of the monocytes to the inflammatory signal transmitted by the A549 through the release of soluble factors (e.g. alarmins and cytokines), THP-1 cells were also exposed to the supernatants of previously nPS/mPS-treated A549. After dynamic-light-scattering (DLS) analysis and protein measurements for the assessment of protein corona in nPS/mPS, real-time PCR and enzyme-linked-immunosorbent (ELISA) assays were performed in exposed cells. The pro-inflammatory effects of v- and ox-nPS/mPS were attested by the imbalance of the Bax/Bcl-2 ratio in A549, which was able to trigger the inflammatory cascade, inhibiting the immunologically silent apoptosis. The involvement of NFkB was confirmed by the overexpression of p65 after exposure to ox-nPS and v- and ox-mPS. The fast and higher levels of IL-1β, only in THP-1 cells, underlined the NLPR3 inflammasome activation.

Published
2024
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29. Functionalized polyhedral oligosilsesquioxane (POSS) based composites for bone tissue engineering: synthesis, computational and biological studies

Author

Legnani, L, Iannazzo, D, Pistone, A, Celesti, C, Giofrè, S, Romeo, R, Di Pietro, A, Visalli, G, Fresta, M, Bottino, P, Blanco, I, Chiacchio, M, Legnani, Laura, Iannazzo, Daniela, Pistone, Alessandro, Celesti, Consuelo, Giofrè, Salvatore, Romeo, Roberto, Di Pietro, Angela, Visalli, Giuseppa, Fresta, Monica, Bottino, Paola, Blanco, Ignazio, Chiacchio, Maria Assunta, Legnani, L, Iannazzo, D, Pistone, A, Celesti, C, Giofrè, S, Romeo, R, Di Pietro, A, Visalli, G, Fresta, M, Bottino, P, Blanco, I, Chiacchio, M, Legnani, Laura, Iannazzo, Daniela, Pistone, Alessandro, Celesti, Consuelo, Giofrè, Salvatore, Romeo, Roberto, Di Pietro, Angela, Visalli, Giuseppa, Fresta, Monica, Bottino, Paola, Blanco, Ignazio, and Chiacchio, Maria Assunta

Abstract

Functionalized polyhedral oligosilsesquioxanes (POSS) containing an isoxazolidine nucleus have been synthesized by microwave assisted 1,3-dipolar cycloaddition of N-methyl-C-alkoxycarbonyl nitrone 1 with POSS containing olefin moieties. The results of cycloaddition processes were rationalized by computational studies at the DFT level. The covalent conjugation of chitosan with the cycloadduct 3a leads to composite material CS-POSS 7 which was gelified using genipin as cross linking agent. The suitability of the system for bone tissue engineering purposes was evaluated by in vitro drug release studies using ketoprofen as a model drug and cytotoxicity assays performed on human fetal osteoblastic cells. The preliminary biological tests showed the lack of cytotoxicity of the hybrid material and suggest its potential role in bone tissue engineering applications.

Published
2020

33. Functionalized polyhedral oligosilsesquioxane (POSS) based composites for bone tissue engineering: synthesis, computational and biological studies

Author

Legnani, Laura, primary, Iannazzo, Daniela, additional, Pistone, Alessandro, additional, Celesti, Consuelo, additional, Giofrè, Salvatore, additional, Romeo, Roberto, additional, Di Pietro, Angela, additional, Visalli, Giuseppa, additional, Fresta, Monica, additional, Bottino, Paola, additional, Blanco, Ignazio, additional, and Chiacchio, Maria Assunta, additional

Published
2020
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34. Engineering of chitosan-hydroxyapatite-magnetite hierarchical scaffolds for guided bone growth

Author

Pistone, Alessandro, Iannazzo, Daniela, Celesti, Consuelo, Piperopoulos, Elpida, Ashok, Deepu, Cembran, Arianna, Tricoli, Antonio, Nisbet, David, Pistone, Alessandro, Iannazzo, Daniela, Celesti, Consuelo, Piperopoulos, Elpida, Ashok, Deepu, Cembran, Arianna, Tricoli, Antonio, and Nisbet, David

Abstract

Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds.

Published
2019

35. A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots

Author

Iannazzo, Daniela, primary, Pistone, Alessandro, additional, Celesti, Consuelo, additional, Triolo, Claudia, additional, Patané, Salvatore, additional, Giofré, Salvatore, additional, Romeo, Roberto, additional, Ziccarelli, Ida, additional, Mancuso, Raffaella, additional, Gabriele, Bartolo, additional, Visalli, Giuseppa, additional, Facciolà, Alessio, additional, and Di Pietro, Angela, additional

Published
2019
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38. Affinity of deep eutectic solvents with aromatic molecules and with aromatic nanostructures in chemical transformations

Author

Giofré, Salvatore V., Celesti, Consuelo, Mistretta, Giuseppe, and Tiecco, Matteo

Abstract

Deep Eutectic Solvents (DESs) are an innovative class of green liquids that are finding fruitful applications as substitutes of polluting organic solvents. One of the topics in which they are finding favourable outcomes is represented by their use in chemical transformations, subject in which they can act as green solvents as well they can participate to the reaction path as catalysts or reagents. Thanks to their structural features, a network of H-bonds between a donor and an acceptor molecule, DESs revealed to be successfully used with aromatic molecules or moieties thanks to the participation of the aromatic rings in this network of weak forces.

Published
2023
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39. Engineering of Chitosan-Hydroxyapatite-Magnetite Hierarchical Scaffolds for Guided Bone Growth.

Author

Pistone A, Celesti C, Piperopoulos E, Ashok D, Cembran A, Tricoli A, and Nisbet D

Abstract

Bioabsorbable materials have received increasing attention as innovative systems for the development of osteoconductive biomaterials for bone tissue engineering. In this paper, chitosan-based composites were synthesized adding hydroxyapatite and/or magnetite in a chitosan matrix by in situ precipitation technique. Composites were characterized by optical and electron microscopy, thermogravimetric analyses (TGA), x-ray diffraction (XRD), and in vitro cell culture studies. Hydroxyapatite and magnetite were found to be homogeneously dispersed in the chitosan matrix and the composites showed superior biocompatibility and the ability to support cell attachment and proliferation; in particular, the chitosan/hydroxyapatite/magnetite composite (CS/HA/MGN) demonstrated superior bioactivity with respect to pure chitosan (CS) and to the chitosan/hydroxyapatite (CS/HA) scaffolds., Competing Interests: The authors declare no conflict of interest.

Published
2019
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