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282 results on '"Cedola, Alessia"'

1. Glioblastoma Treatments with Photo-Nanotherapeutics Induce Massive Devascularization and Tumor Elimination

Author

Ricciardi, Loredana, Chatterjee, Sharmistha, Palermo, Giovanna, Szerb, Elisabeta I., Sanna, Alessia, Palermo, Francesca, Pieroni, Nicola, Fratini, Michela, Bartolino, Roberto, Cedola, Alessia, La Deda, Massimo, and Strangi, Giuseppe

Subjects
Physics - Applied Physics
Abstract

Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report in vivo studies of GBM treatments based on photo-nanotherapeutics able to induce synergistic killing mechanisms. Core-shell nanoparticles have been weaponized by combining the photophysical properties of an Ir(III) complex - a new generation PDT agent - with the thermo-plasmonic effects of resonant gold nanospheres. To investigate the damages induced in GBM treated with these nanosystems and exposed to optical radiation, we recurred to the X-ray phase contrast tomography (XPCT). This high-resolution 3D imaging technique highlighted a vast devascularization process by micro-vessels disruption, which is responsible of a tumor elimination without relapse.

Published
2021

4. Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in multiple sclerosis

Author

Palermo, Francesca, Pieroni, Nicola, Sanna, Alessia, Parodi, Benedetta, Venturi, Consuelo, Begani Provinciali, Ginevra, Massimi, Lorenzo, Maugeri, Laura, Marra, Gian Paolo, Longo, Elena, D’Amico, Lorenzo, Saccomano, Giulia, Perrin, Jonathan, Tromba, Giuliana, Bukreeva, Inna, Fratini, Michela, Gigli, Giuseppe, Kerlero de Rosbo, Nicole, and Cedola, Alessia

Published
2022
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5. Investigating Herculaneum papyri: An innovative 3D approach for the virtual unfolding of the rolls

Author

Bukreeva, Inna, Alessandrelli, Michele, Formoso, Vincenzo, Ranocchia, Graziano, and Cedola, Alessia

Subjects
Physics - Instrumentation and Detectors, Physics - Applied Physics
Abstract

After the first recent attempts at virtually opening and reading Herculaneum papyri, a new enhanced method for virtual unfolding and peeling of ancient unopened papyrus rolls has been developed. This new algorithms-based and semi-automatic procedure allowed to investigate with high resolution the 3D internal structure of two ancient papyrus rolls formerly analysed by X-ray phase-contrast tomography. Through a new rendering procedure, selected regions inside the rolls could be identified and isolated and the different sheets could be peeled one by one virtually, all without damaging these very precious manuscripts. Subsequently, traces of possible text were identified on the single sheets. Finally, by applying an additional flattening procedure we restored for the first time several extensive textual portions of Greek, the largest ever detected so far in unopened Herculaneum papyrus rolls, with different degrees of resolution and contrast

Published
2017

8. Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

Author

Fratini, Michela, Bukreeva, Inna, Campi, Gaetano, Brun, Francesco, Tromba, Giuliana, Modregger, Peter, Bucci, Domenico, Battaglia, Giuseppe, Spadon, Raffaele, Mastrogiacomo, Maddalena, Requardt, Herwig, Giove, Federico, Bravin, Alberto, and Cedola, Alessia

Subjects
Physics - Medical Physics
Abstract

Defaults in vascular (VN) and neuronal networks of spinal cord are responsible for serious neurodegenerative pathologies. Because of inadequate investigation tools, the lacking knowledge of the complete fine structure of VN and neuronal systems is a crucial problem. Conventional 2D imaging yields incomplete spatial coverage leading to possible data misinterpretation, whereas standard 3D computed tomography imaging achieves insufficient resolution and contrast. We show that X-ray high-resolution phase-contrast tomography allows the simultaneous visualization of three-dimensional VN and neuronal systems of mouse spinal cord at scales spanning from millimeters to hundreds of nanometers, with neither contrast agent nor a destructive sample-preparation. We image both the 3D distribution of micro-capillary network and the micrometric nerve fibers, axon-bundles and neuron soma. Our approach is a crucial tool for pre-clinical investigation of neurodegenerative pathologies and spinal-cord-injuries. In particular, it should be an optimal tool to resolve the entangled relationship between VN and neuronal system., Comment: 15 pages, 6 figures

Published
2014

12. Mapping cellular magnesium using X-ray microfluorescence and atomic force microscopy

Author

Lagomarsino, Stefano, Iotti, Stefano, Farruggia, Giovanna, Cedola, Alessia, Trapani, Valentina, Fratini, Michela, Bukreeva, Inna, Notargiacomo, Andrea, Mastrototaro, Lucia, McNulty, Ian, Vogt, Stefan, Legnini, Daniel, Kim, Sangsoo, Maier, Jeanette A M, and Wolf, Federica I

Subjects
Quantitative Biology - Cell Behavior, Physics - Medical Physics
Abstract

Magnesium is the most abundant intracellular divalent cation. We present an innovative experimental approach to localizing intracellular magnesium that combines elemental and morphological information from individual cells with high-resolution spatial information. Integration of information from scanning fluorescence X-ray microscopy with information from atomic force microscopy was used to generate a magnesium concentration map and to determine the X-ray linear absorption coefficient map within a whole dehydrated mammary epithelial cell., Comment: 9 pages, 2 figures

Published
2010

13. The Study of the Caudal Vertebrae of Thick-Toed Geckos after a Prolonged Space Flight by X-ray Phase-Contrast Micro-CT

Author

Bukreeva, Inna, primary, Gulimova, Victoria I., additional, Krivonosov, Yuri S., additional, Buzmakov, Alexey V., additional, Junemann, Olga, additional, Cedola, Alessia, additional, Fratini, Michela, additional, Maugeri, Laura, additional, Begani Provinciali, Ginevra, additional, Palermo, Francesca, additional, Sanna, Alessia, additional, Pieroni, Nicola, additional, Asadchikov, Victor E., additional, and Saveliev, Sergey V., additional

Published
2023
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14. Lesion Extension and Neuronal Loss after Spinal Cord Injury Using X-Ray Phase-Contrast Tomography in Mice

Author

Maugeri, Laura, primary, Jankovski, Aleksandar, additional, Malucelli, Emil, additional, Mangini, Fabio, additional, Vandeweerd, Jean-Michel, additional, Gilloteaux, Jacques, additional, De Swert, Kathleen, additional, Brun, Francesco, additional, Begani Provinciali, Ginevra, additional, DiNuzzo, Mauro, additional, Mittone, Alberto, additional, Bravin, Alberto, additional, Gigli, Giuseppe, additional, Giove, Federico, additional, Cedola, Alessia, additional, Nicaise, Charles, additional, and Fratini, Michela, additional

Published
2023
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21. Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies

Author

Sandonà, Martina, Cavioli, Giorgia, Renzini, Alessandra, Cedola, Alessia, Gigli, Giuseppe, Coletti, Dario, Mckinsey, Timothy A, Moresi, Viviana, Saccone, Valentina, Saccone, Valentina (ORCID:0000-0002-0566-6384), Sandonà, Martina, Cavioli, Giorgia, Renzini, Alessandra, Cedola, Alessia, Gigli, Giuseppe, Coletti, Dario, Mckinsey, Timothy A, Moresi, Viviana, Saccone, Valentina, and Saccone, Valentina (ORCID:0000-0002-0566-6384)

Abstract

Histone deacetylases (HDACs) are enzymes that regulate the deacetylation of numerous histone and non-histone proteins, thereby affecting a wide range of cellular processes. Deregulation of HDAC expression or activity is often associated with several pathologies, suggesting potential for targeting these enzymes for therapeutic purposes. For example, HDAC expression and activity are higher in dystrophic skeletal muscles. General pharmacological blockade of HDACs, by means of pan-HDAC inhibitors (HDACi), ameliorates both muscle histological abnormalities and function in preclinical studies. A phase II clinical trial of the pan-HDACi givinostat revealed partial histological improvement and functional recovery of Duchenne Muscular Dystrophy (DMD) muscles; results of an ongoing phase III clinical trial that is assessing the long-term safety and efficacy of givinostat in DMD patients are pending. Here we review the current knowledge about the HDAC functions in distinct cell types in skeletal muscle, identified by genetic and -omic approaches. We describe the signaling events that are affected by HDACs and contribute to muscular dystrophy pathogenesis by altering muscle regeneration and/or repair processes. Reviewing recent insights into HDAC cellular functions in dystrophic muscles provides new perspectives for the development of more effective therapeutic approaches based on drugs that target these critical enzymes.

Published
2023

23. Contributors

Author

Addis, Anna, primary, Alessandrelli, Michele, additional, Andreani, Carla, additional, Arcidiacono, Laura, additional, Baglioni, Piero, additional, Baglioni, Michele, additional, Barresi, Giovanna, additional, Batasheva, Svetlana, additional, Bernabei, Mauro, additional, Bernardini, Federico, additional, Bonelli, Nicole, additional, Bukreeva, Inna, additional, Cappa, Federica, additional, Cavallaro, Giuseppe, additional, Cedola, Alessia, additional, Chelazzi, David, additional, Cherubini, Paolo, additional, Ciccola, Alessandro, additional, Drobyshev, Sergey, additional, Duce, Celia, additional, Fakhrullin, Rawil, additional, Festa, Giulia, additional, Formoso, Vincenzo, additional, Fratini, Michela, additional, Fruehmann, Bernadette, additional, Giordano, Ambra, additional, Giorgi, Rodorico, additional, Grazzi, Francesco, additional, Kardjilov, Nikolay, additional, Khramchenkova, Rezida, additional, Krčma, Frantisek, additional, Lazzara, Giuseppe, additional, Manke, Ingo, additional, Martinelli, Nicoletta, additional, Massimi, Lorenzo, additional, Milioto, Stefana, additional, Nuzhdin, Evgeny, additional, Palla, Franco, additional, Parisi, Filippo, additional, Ranocchia, Graziano, additional, Riela, Serena, additional, Rotolo, Valentina, additional, Safina, Ilvina, additional, Schiavone, Salvatore, additional, Schreiner, Manfred, additional, Secco, Michele, additional, Senesi, Roberto, additional, Serafini, Ilaria, additional, Tiné, Maria Rosaria, additional, Tiňo, Radko, additional, Tuniz, Claudio, additional, Valentini, Luca, additional, Vizárová, Katarína, additional, Woracek, Robin, additional, and Zanini, Franco, additional

Published
2018
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25. Micromorphology of pineal gland calcification in age‐related neurodegenerative diseases

Author

Bukreeva, Inna, primary, Junemann, Olga, additional, Cedola, Alessia, additional, Brun, Francesco, additional, Longo, Elena, additional, Tromba, Giuliana, additional, Wilde, Fabian, additional, Chukalina, Marina V., additional, Krivonosov, Yuri S., additional, Dyachkova, Irina G., additional, Buzmakov, Alexey V., additional, Zolotov, Denis A., additional, Palermo, Francesca, additional, Gigli, Giuseppe, additional, Otlyga, Dmitry A., additional, Saveliev, Sergey V., additional, Fratini, Michela, additional, and Asadchikov, Victor E., additional

Published
2022
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27. Theoretical Analysis of X-Ray Waveguides

Author

Lagomarsino, Stefano, Bukreeva, Inna, Cedola, Alessia, Pelliccia, Daniele, Jark, Werner, Rhodes, William T., editor, Erko, Alexei, editor, Idir, Mourad, editor, Krist, Thomas, editor, and Michette, Alan G., editor

Published
2008
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28. Deep Learning-Based Segmentation of Post-Mortem Human’s Olfactory Bulb Structures in X-ray Phase-Contrast Tomography

Author

Meshkov, Alexandr, primary, Khafizov, Anvar, additional, Buzmakov, Alexey, additional, Bukreeva, Inna, additional, Junemann, Olga, additional, Fratini, Michela, additional, Cedola, Alessia, additional, Chukalina, Marina, additional, Yamaev, Andrei, additional, Gigli, Giuseppe, additional, Wilde, Fabian, additional, Longo, Elena, additional, Asadchikov, Victor, additional, Saveliev, Sergey, additional, and Nikolaev, Dmitry, additional

Published
2022
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29. Innovative hierarchical X-ray imaging approach to assess the sequential evolution of multi-organ damage in multiple sclerosis

Author

Palermo, Francesca, primary, Pieroni, Nicola, additional, Sanna, Alessia, additional, Parodi, Benedetta, additional, Venturi, Consuelo, additional, Provinciali, Ginevra Begani, additional, Massimi, Lorenzo, additional, Maugeri, Laura, additional, Marra, Gian Paolo, additional, Longo, Elena, additional, D'Amico, Lorenzo, additional, Saccomano, Giulia, additional, Perrin, Jonathan, additional, Tromba, Giuliana, additional, Bukreeva, Inna, additional, Fratini, Michela, additional, Gigli, Giuseppe, additional, de Rosbo, Nicole Kerlero, additional, and Cedola, Alessia, additional

Published
2022
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30. Element differentiation with a Hartmann- based X-ray phase imaging system

Author

de La Rochefoucauld, Ombeline, primary, Begani Provinciali, Ginevra, additional, Cedola, Alessia, additional, Cook, Philip K., additional, Di Lillo, Francesca, additional, Dovillaire, Guillaume, additional, Harms, Fabrice, additional, Idir, Mourad, additional, Levecq, Xavier, additional, Oudjedi, Laura, additional, Phan, Tan-Binh, additional, Piponnier, Martin, additional, Tromba, Giuliana, additional, and Zeitoun, Philippe, additional

Published
2022
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32. Micromorphology of pineal gland calcification in age-related neurodegenerative diseases.

Author

Bukreeva, Inna, Junemann, Olga, Cedola, Alessia, Brun, Francesco, Longo, Elena, Tromba, Giuliana, Wilde, Fabian, Chukalina, Marina V., Krivonosov, Yuri S., Dyachkova, Irina G., Buzmakov, Alexey V., Zolotov, Denis A., Palermo, Francesca, Gigli, Giuseppe, Otlyga, Dmitry A., Saveliev, Sergey V., Fratini, Michela, and Asadchikov, Victor E.

Subjects
PINEAL gland, NEURODEGENERATION, CALCIFICATION, ALZHEIMER'S disease, THREE-dimensional imaging
Abstract

Background: The formation of concrements in human pineal gland (PG) is a physiological process and, according to many researchers, is associated with the involution of PG structures. The majority of scientific publications concern progressive calcification of PG, leaving out studies on the destruction of already formed calcified concrements. Our study fills the gap in knowledge about calcified zones destruction in PG in normal aging and neuropathological conditions, which has not been addressed until now. Purpose: Our objective is to gain insight into human PG tissue impairment in both normal aging and neurodegenerative conditions. X-ray phase-contrast tomography (XPCT) allowed us to study PG tissue degeneration at high spatial resolution and, for the first time, to examine the damaged PG concrements in detail. Our research finding could potentially enhance the understanding of the PG involvement in the process of aging as well as in Alzheimer’s disease (AD) and vascular dementia (VD). Methods: The research was carried out on human PG autopsy material in normal aging, VD, and AD conditions. Laboratory-based micro-computed tomography (micro-CT) was used to collect and evaluate samples of native, uncut, and unstained PG with different degrees of pineal calcification. The detailed high-resolution 3D images of the selected PGs were produced using synchrotron-based XPCT. Histology and immunohistochemistry of soft PG tissue confirmed XPCT results. Results: We performed via micro-CT the evaluation of the morphometric parameters of PG such as total sample volume, calcified concrements volume, and percentage of concrements in the total volume of the sample.XPCT imaging revealed high-resolution details of age-related PGalteration.In particular,we noted signs of moderate degradation of concrements in some PGs from elderly donors. In addition, our analysis revealed noticeable degenerative change in both concrements and soft tissue of PGs with neuropathology. In particular, we observed a hollow core and separated layers as well as deep ragged cracks in PG concrements of AD and VD samples. In parenchyma of some samples,we detected wide pinealocyte-free fluid-filled areas adjacent to the calcified zones. Conclusion: The present work provides the basis for future scientific research focused on the dynamic nature of PG calcium deposits and PG soft tissue in normal aging and neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Human Pineal Gland Involutionary Process: New Findings.

Author

Junemann, Olga, Bukreeva, Inna, Otlyga, Dmitry A, Cedola, Alessia, Fratini, Michela, and Saveliev, Sergei V

Subjects
PINEAL gland, CONNECTIVE tissues, OLDER people, AUTOPSY, HISTOLOGY
Abstract

In this work, we report preliminary results about the involution of the human pineal gland involution. The detailed analysis of pineal structure was done on autopsy material of 77 persons in age 27–96 using x-ray phase-contrast tomography, histology, and immunohistochemistry. Our study suggests that the pineal gland alteration in older adults may be more profound than has been reported to date. We identified and described a new form of pineal gland involution that eventually led to the total degradation of the pineal gland. To our knowledge, this study is the first to report on the complete replacement of pineal gland parenchyma with connective tissue in older adults. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Intracellular concentration map of magnesium in whole cells by combined use of X-ray fluorescence microscopy and atomic force microscopy

Author

Lagomarsino, Stefano, Iotti, Stefano, Farruggia, Giovanna, Cedola, Alessia, Trapani, Valentina, Fratini, Michela, Bukreeva, Inna, Notargiacomo, Andrea, Mastrototaro, Lucia, Marraccini, Chiara, Sorrentino, Andrea, McNulty, Ian, Vogt, Stefan, Legnini, Daniel, Kim, Sangsoo, Gianoncelli, Alessandra, Maier, Jeanette A.M., and Wolf, Federica I.

Published
2011
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35. Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations

Author

Ricciardi, Loredana, primary, Chatterjee, Sharmistha, additional, Palermo, Giovanna, additional, Szerb, Elisabeta I., additional, Sanna, Alessia, additional, Palermo, Francesca, additional, Pieroni, Nicola, additional, Fratini, Michela, additional, Bartolino, Roberto, additional, Cedola, Alessia, additional, La Deda, Massimo, additional, and Strangi, Giuseppe, additional

Published
2022
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38. Sex and HDAC4 Differently Affect the Pathophysiology of Amyotrophic Lateral Sclerosis in SOD1-G93A Mice.

Author

Renzini, Alessandra, Pigna, Eva, Rocchi, Marco, Cedola, Alessia, Gigli, Giuseppe, Moresi, Viviana, and Coletti, Dario

Subjects
AMYOTROPHIC lateral sclerosis, PATHOLOGICAL physiology, MOTOR neuron diseases, MUSCULAR atrophy, SKELETAL muscle, HISTONE deacetylase, MICE, FEMALES, SEX (Biology)
Abstract

Amyotrophic Lateral Sclerosis (ALS) is a devastating adult-onset neurodegenerative disease, with ineffective therapeutic options. ALS incidence and prevalence depend on the sex of the patient. Histone deacetylase 4 (HDAC4) expression in skeletal muscle directly correlates with the progression of ALS, pointing to the use of HDAC4 inhibitors for its treatment. Contrarily, we have found that deletion of HDAC4 in skeletal muscle worsened the pathological features of ALS, accelerating and exacerbating skeletal muscle loss and negatively affecting muscle innervations in male SOD1-G93A (SOD1) mice. In the present work, we compared SOD1 mice of both sexes with the aim to characterize ALS onset and progression as a function of sex differences. We found a global sex-dependent effects on disease onset and mouse lifespan. We further investigated the role of HDAC4 in SOD1 females with a genetic approach, and discovered morpho-functional effects on skeletal muscle, even in the early phase of the diseases. The deletion of HDAC4 decreased muscle function and exacerbated muscle atrophy in SOD1 females, and had an even more dramatic effect in males. Therefore, the two sexes must be considered separately when studying ALS. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Study of sodium depositions in heart interstitium using methods of X-ray absorption and X-ray fluorescence microscopy

Author

Artyukov, Igor A., primary, Arutyunov, Grigori P., additional, Bobrov, Maksim A., additional, Bukreeva, Inna N., additional, Cedola, Alessia, additional, Dragunov, Dmitri O., additional, Feshchenko, Ruslan F., additional, Fratini, Michela, additional, Gianoncelli, Alessandra, additional, Mitrokhin, Vadim ., additional, Sokolova, Anna ., additional, and Vinogradov, Alexander V., additional

Published
2021
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44. X‐ray microtomography and phylogenomics provide insights into the morphology and evolution of an enigmatic Mesozoic insect larva

Author

Badano, Davide, primary, Fratini, Michela, additional, Maugeri, Laura, additional, Palermo, Francesca, additional, Pieroni, Nicola, additional, Cedola, Alessia, additional, Haug, Joachim T., additional, Weiterschan, Thomas, additional, Velten, Jürgen, additional, Mei, Maurizio, additional, Di  Giulio, Andrea, additional, and Cerretti, Pierfilippo, additional

Published
2021
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45. 3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography

Author

Longo, Elena, primary, Sancey, Lucie, additional, Cedola, Alessia, additional, Barbier, Emmanuel L., additional, Bravin, Alberto, additional, Brun, Francesco, additional, Bukreeva, Inna, additional, Fratini, Michela, additional, Massimi, Lorenzo, additional, Greving, Imke, additional, Le Duc, Geraldine, additional, Tillement, Olivier, additional, De La Rochefoucauld, Ombeline, additional, and Zeitoun, Philippe, additional

Published
2021
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47. Corrigendum: X-ray Phase Contrast Tomography Serves Preclinical Investigation of Neurodegenerative Diseases

Author

Palermo, Francesca, primary, Pieroni, Nicola, additional, Maugeri, Laura, additional, Provinciali, Ginevra Begani, additional, Sanna, Alessia, additional, Bukreeva, Inna, additional, Massimi, Lorenzo, additional, Catalano, Maura, additional, Olbinado, Margie P., additional, Fratini, Michela, additional, Uccelli, Antonio, additional, Gigli, Giuseppe, additional, Kerlero de Rosbo, Nicole, additional, Balducci, Claudia, additional, and Cedola, Alessia, additional

Published
2021
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49. X-ray Phase Contrast Tomography for the investigation of ALS disease

Author

Begani Provinciali, Ginevra, Cedola, Alessia, Begani Provinciali, Ginevra, CNR Istituto di Nanotecnologia (NANOTEC), and Consiglio Nazionale delle Ricerche [Roma] (CNR)

Subjects
[PHYS.PHYS.PHYS-OPTICS] Physics [physics]/Physics [physics]/Optics [physics.optics], [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

50. Multiscale pink-beam microCT imaging at the ESRF-ID17 biomedical beamline

Author

Mittone, Alberto, Fardin, Luca, Di Lillo, Francesca, Fratini, Michela, Requardt, Herwig, Mauro, Anthony, Homs-Regojo, Roberto Arturo, Douissard, Paul-Antoine, Barbone, Giacomo E., Stroebel, Johannes, Romano, Mariele, Massimi, Lorenzo, Begani-Provinciali, Ginevra, Palermo, Francesca, Bayat, Sam, Cedola, Alessia, Coan, Paola, Bravin, Alberto, Mittone, Alberto, Fardin, Luca, Di Lillo, Francesca, Fratini, Michela, Requardt, Herwig, Mauro, Anthony, Homs-Regojo, Roberto Arturo, Douissard, Paul-Antoine, Barbone, Giacomo E., Stroebel, Johannes, Romano, Mariele, Massimi, Lorenzo, Begani-Provinciali, Ginevra, Palermo, Francesca, Bayat, Sam, Cedola, Alessia, Coan, Paola, and Bravin, Alberto

Abstract

Recent trends in hard X-ray micro-computed tomography (microCT) aim at increasing both spatial and temporal resolutions. These challenges require intense photon beams. Filtered synchrotron radiation beams, also referred to as 'pink beams', which are emitted by wigglers or bending magnets, meet this need, owing to their broad energy range. In this work, the new microCT station installed at the biomedical beamline ID17 of the European Synchrotron is described and an overview of the preliminary results obtained for different biomedical-imaging applications is given. This new instrument expands the capabilities of the beamline towards sub-micrometre voxel size scale and simultaneous multi-resolution imaging. The current setup allows the acquisition of tomographic datasets more than one order of magnitude faster than with a monochromatic beam configuration.

Published
2020
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