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2. Prevalence of Fabry disease and GLA variants in young patients with acute stroke: The challenge to widen the screening. The Fabry-Stroke Italian Registry

Author

Romani, Ilaria, Sarti, Cristina, Nencini, Patrizia, Pracucci, Giovanni, Zedde, Marialuisa, Cianci, Vittoria, Nucera, Antonia, Moller, Jessica, Orsucci, Daniele, Toni, Danilo, Palumbo, Pasquale, Casella, Carmela, Pinto, Vincenza, Barbarini, Leonardo, Bella, Rita, Scoditti, Umberto, Ragno, Michele, Mezzapesa, Domenico Maria, Tassi, Rossana, Volpi, Gino, Diomedi, Marina, Bigliardi, Guido, Cavallini, Anna Maria, Chiti, Alberto, Ricci, Stefano, Cecconi, Emanuela, Linoli, Giovanni, Sacco, Simona, Rasura, Maurizia, Giordano, Antonello, Bonetti, Bruno, Melis, Marta, Cariddi, Lucia Princiotta, Dossi, Roberto Currò, Grisendi, Ilaria, Aguglia, Umberto, Di Ruzza, Maria Rita, Melis, Maurizio, Sbardella, Emilia, Vista, Marco, Valenti, Raffaella, Musolino, Rosa Fortunata, Passarella, Bruno, Direnzo, Vita, Pennisi, Giovanni, Genovese, Antonio, Di Marzio, Fabio, Sgobio, Rossana, Acampa, Maurizio, Nannucci, Serena, Dagostino, Federica, Dell'Acqua, Maria Luisa, Cuzzoni, Maria Giovanna, Picchioni, Antonella, Calchetti, Benedetta, Notturno, Francesca, Di Lisi, Filomena, Forlivesi, Stefano, Delodovici, Maria Luisa, Buechner, Susanne Christiane, Biagini, Silvia, Accavone, Donatella, Manna, Raffaele, Morrone, Amelia, and Inzitari, Domenico

Published
2024
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3. Fabry-Stroke Italian Registry (FSIR): a nationwide, prospective, observational study about incidence and characteristics of Fabry-related stroke in young-adults. Presentation of the study protocol

Author

Romani, Ilaria, Nencini, Patrizia, Sarti, Cristina, Pracucci, Giovanni, Zedde, Marialuisa, Nucera, Antonia, Cianci, Vittoria, Moller, Jessica, Toni, Danilo, Orsucci, Daniele, Casella, Carmela, Pinto, Vincenza, Palumbo, Pasquale, Barbarini, Leonardo, Bella, Rita, Ragno, Michele, Scoditti, Umberto, Mezzapesa, Domenico Maria, Tassi, Rossana, Diomedi, Marina, Cavallini, Anna, Volpi, Gino, Chiti, Alberto, Bigliardi, Guido, Sacco, Simona, Linoli, Giovanni, Ricci, Stefano, Giordano, Antonello, Bonetti, Bruno, Rasura, Maurizia, Cecconi, Emanuela, Princiotta Cariddi, Lucia, Currò Dossi, Roberto, Melis, Marta, Consoli, Domenico, Guidetti, Donata, Biagini, Silvia, Accavone, Donatella, and Inzitari, Domenico

Published
2022
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4. Effect of the COVID-19 pandemic and the lockdown measures on the local stroke network

Author

Brunetti, Valerio, Broccolini, Aldobrando, Caliandro, Pietro, Di Iorio, Riccardo, Monforte, Mauro, Morosetti, Roberta, Piano, Carla, Pilato, Fabio, Bellavia, Simone, Marotta, Jessica, Scala, Irene, Pedicelli, Alessandro, Pennisi, Mariano Alberto, Caricato, Anselmo, Roberti, Cinzia, Altavista, Maria Concetta, Valenza, Alessandro, Distefano, Marisa, Cecconi, Emanuela, Fanella, Martina, Roncacci, Sabina, Tasillo, Miriam, Calabresi, Paolo, Frisullo, Giovanni, and Marca, Giacomo Della

Published
2021
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7. Fabry-Stroke Italian Registry (FSIR): a nationwide, prospective, observational study about incidence and characteristics of Fabry-related stroke in young-adults. Presentation of the study protocol

Author

Romani, Ilaria, primary, Nencini, Patrizia, additional, Sarti, Cristina, additional, Pracucci, Giovanni, additional, Zedde, Marialuisa, additional, Nucera, Antonia, additional, Cianci, Vittoria, additional, Moller, Jessica, additional, Toni, Danilo, additional, Orsucci, Daniele, additional, Casella, Carmela, additional, Pinto, Vincenza, additional, Palumbo, Pasquale, additional, Barbarini, Leonardo, additional, Bella, Rita, additional, Ragno, Michele, additional, Scoditti, Umberto, additional, Mezzapesa, Domenico Maria, additional, Tassi, Rossana, additional, Diomedi, Marina, additional, Cavallini, Anna, additional, Volpi, Gino, additional, Chiti, Alberto, additional, Bigliardi, Guido, additional, Sacco, Simona, additional, Linoli, Giovanni, additional, Ricci, Stefano, additional, Giordano, Antonello, additional, Bonetti, Bruno, additional, Rasura, Maurizia, additional, Cecconi, Emanuela, additional, Princiotta Cariddi, Lucia, additional, Currò Dossi, Roberto, additional, Melis, Marta, additional, Consoli, Domenico, additional, Guidetti, Donata, additional, Biagini, Silvia, additional, Accavone, Donatella, additional, and Inzitari, Domenico, additional

Published
2021
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8. Reduced Admissions for Cerebrovascular Events During COVID-19 Outbreak in Italy

Author

Sacco, Simona, primary, Ricci, Stefano, additional, Ornello, Raffaele, additional, Eusebi, Paolo, additional, Petraglia, Luca, additional, Toni, Danilo, additional, Rota, Eugenia, additional, Bruzzone, Gianluca, additional, Testa, Lucia, additional, Bongioanni, Roberta, additional, Rosso, Mara, additional, Labate, Carmelo, additional, Tarletti, Roberto, additional, Cantello, Roberto, additional, Fleetwood, Thomas, additional, Melis, Fabio, additional, Imperiale, Daniele, additional, Amarù, Salvatore, additional, Reggiani, Monica, additional, Ruiz, Luigi, additional, Cipriano, Elia, additional, Ferrandi, Delfina, additional, Julita, Patrizia, additional, Africa, Liana, additional, Meinieri, Piero, additional, Grasso, Maria Federica, additional, Servo, Serena, additional, Cavallo, Roberto, additional, Chianale, Gigliola, additional, Naldi, Andrea, additional, Cerrato, Paolo, additional, Rubino, Elisa, additional, Giossi, Alessia, additional, Puglisi, Valentina, additional, Vinciguerra, Luisa, additional, Santilli, Ignazio, additional, Bordo, Bianca Maria, additional, Marcheselli, Simona, additional, Bottini, Julia, additional, D’Alessandro, Caterina Mariotto, additional, Micieli, Giuseppe, additional, Cavallini, Anna, additional, Canavero, Isabella, additional, Muscia, Francesco, additional, Nuzzaco, Graziamaria, additional, Ciccone, Alfonso, additional, Silvestrelli, Giorgio, additional, Salmaggi, Andrea, additional, Sangalli, Davide, additional, Zanferrari, Carla, additional, Fanucchi, Simona, additional, Ranieri, Michela, additional, Beretta, Simone, additional, Ferrarese, Carlo, additional, Pasini, Francesco, additional, Santangelo, Francesco, additional, Checcarelli, Nicoletta, additional, Beretta, Sandro, additional, Bazzi, Paola, additional, Camerlingo, Massimo, additional, Tognozzi, Marcello, additional, Caneve, Giorgio, additional, Adami, Alessandro, additional, Quatrale, Rocco, additional, Critelli, Adriana, additional, Bartolomei, Luigi, additional, Masato, Maela, additional, Perini, Francesco, additional, De Boni, Antonella, additional, Disco, Caterina, additional, Baracchini, Claudio, additional, Pieroni, Alessio, additional, Lerario, Roberto, additional, Russo, Monia, additional, Polo, Alberto, additional, Danese, Alessandra, additional, Valentinis, Luca, additional, Baldi, Antonio, additional, Tonello, Simone, additional, Paladin, Francesco, additional, Tonon, Agnese, additional, Bonetti, Bruno, additional, Cappellari, Manuel, additional, Teatini, Francesco, additional, Dossi, Roberto Currò, additional, Franchini, Enrica, additional, Giometto, Bruno, additional, Bignamini, Valeria, additional, Manganotti, Paolo, additional, Naccarato, Marcello, additional, Gigli, Gian Luigi, additional, Lorenzut, Simone, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Rana, Michele, additional, Gentile, Carolina, additional, Tassinari, Tiziana, additional, Sugo, Annalisa, additional, Saia, Valentina, additional, Balestrino, Maurizio, additional, Coccia, Alberto, additional, Finocchi, Cinzia, additional, Valzania, Franco, additional, Zedde, Maria Luisa, additional, Toschi, Giulia, additional, Longoni, Marco, additional, Paolucci, Matteo, additional, Tugnoli, Valeria, additional, Querzani, Pietro, additional, Padroni, Marina, additional, Meletti, Stefano, additional, Bigliardi, Guido, additional, Dall’Acqua, Maria Luisa, additional, Zini, Andrea, additional, Gentile, Mauro, additional, Migliaccio, Ludovica, additional, Chiti, Alberto, additional, Tassi, Rossana, additional, Martini, Giuseppe, additional, Nencini, Patrizia, additional, Lamassa, Maria, additional, Mancuso, Michelangelo, additional, Orlandi, Giovanni, additional, Ferrari, Elena, additional, Marconi, Roberto, additional, Gallerini, Simone, additional, Groggia, Vincenzo, additional, Volpi, Gino, additional, Menichetti, Chiara, additional, Spolveri, Stefano, additional, Silvestrini, Mauro, additional, Viticchi, Giovanna, additional, Buratti, Laura, additional, Pelliccioni, Giuseppe, additional, Potente, Eleonora, additional, Mazzoli, Tatiana, additional, Marsili, Erica, additional, Cenciarelli, Silvia, additional, Picchioni, Antonella, additional, Costantini, Franco, additional, Colosimo, Carlo, additional, Paciaroni, Maurizio, additional, Caso, Valeria, additional, Rasura, Maurizia, additional, Beccia, Mario, additional, Falcone, Nicola, additional, Di Stefano, Marisa, additional, Cecconi, Emanuela, additional, Anticoli, Sabrina, additional, Pezzella, Francesca Romana, additional, Mangiardi, Marilena, additional, Plocco, Maurizio, additional, Magarelli, Maria, additional, Saggese, Carlo Emanuele, additional, Berto, Irene, additional, Altavista, Maria Concetta, additional, Roberti, Cinzia, additional, Diomedi, Marina, additional, Sallustio, Fabrizio, additional, Rocco, Alessandro, additional, Cupini, Letizia Maria, additional, Bonaffini, Novella, additional, De Angelis, Maria Vittoria, additional, Digiovanni, Anna, additional, Rispoli, Marianna, additional, Orlandi, Berardino, additional, Santis, Federica De, additional, Colangeli, Enrico, additional, Blasio, Francesco Di, additional, Carmine, Caterina Di, additional, Tocco, Pierluigi, additional, Melis, Maurizio, additional, Moller, Jessica, additional, Saddi, Valeria, additional, Manca, Antonio, additional, Baule, Antonio, additional, Caddeo, Antonello, additional, Iorio, Nicola, additional, Napoletano, Rosa, additional, di Gregorio, Maria, additional, Volpe, Giampiero, additional, D’Onofrio, Florindo, additional, Spitaleri, Daniele, additional, Barbarini, Leonardo, additional, Barbagallo, Gaetano, additional, Caggiula, Marcella, additional, Ardito, Bonaventura, additional, Noia, Domenico Di, additional, Viesti, Pietro Di, additional, Leone, Maurizio Angelo, additional, Inchingolo, Vincenzo, additional, Petruzzellis, Marco, additional, Rizzo, Federica, additional, Savarese, Mariantonietta, additional, Petrone, Alfredo, additional, Galati, Franco, additional, Arcudi, Luciano, additional, Branca, Damiano, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Musolino, Rosa, additional, Dell’Aera, Cristina, additional, Francalanza, Isabella, additional, Grimaldi, Luigi, additional, Gammino, Matilde, additional, Giordano, Antonello, additional, Zelante, Giuseppe, additional, Sanzaro, Enzo, additional, and Gasparro, Antonio, additional

Published
2020
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11. Neuroanatomical, Clinical and Cognitive Correlates of Post-Stroke Dysphagia

Author

Toscano, Massimiliano, primary, Cecconi, Emanuela, additional, Capiluppi, Elisa, additional, Viganò, Alessandro, additional, Bertora, Pierluigi, additional, Campiglio, Laura, additional, Mariani, Claudio, additional, Petolicchio, Barbara, additional, Sasso D''Elia, Tullia, additional, Verzina, Angela, additional, Vicenzini, Edoardo, additional, Fiorelli, Marco, additional, Cislaghi, Giuliana, additional, and Di Piero, Vittorio, additional

Published
2015
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14. Early Hospital Discharge on Day Two Post-Robotic Lobectomy with Telehealth Home Monitoring.

Author

Mangiameli G, Bottoni E, Tagliabue A, Giudici VM, Crepaldi A, Testori A, Voulaz E, Cariboni U, Re Cecconi E, Luppichini M, Alloisio M, Brascia D, Morenghi E, and Marulli G

Abstract

Background: Despite the implementation of enhanced recovery programs, the reported average postoperative length of stay after robotic lobectomy remains as 4 days. In this prospective study, we present the outcomes of early discharge (on day 2) with telehealth home monitoring device after robotic lobectomy for lung cancer in selected patients. Methods: All patients with a caregiver were discharged on postoperative day 2 (POD 2) with a telemonitoring device provided they met the specific discharge criteria. Inclusion criteria: <75 years old, stage I-II NSCLC, with caregiver, ECOG 0-2, scheduled for lobectomy, logistic proximity to hospital (<60 km); intra-postoperative exclusion criteria: conversion to open surgery, early complications needing hospital monitoring or redo-operation, difficult pain management, <92 HbO2% saturation on room air or need for O2 supplementation, altered vital or laboratory parameters. Teleconsultations were scheduled as follows: the first one in afternoon of POD2, two on POD3, then once a day until chest tube removal. After discharge, patients recorded their vital signs at least four times a day using the device, which allowed two surgeons to monitor them via a mobile application. In the event of sudden changes in vital signs or the occurrence of adverse events, patients had access to a direct phone line and a dedicated re-hospitalization pathway. The primary outcome was safety, assessed by the occurrence of post-discharge complications or readmissions, as well as feasibility. Secondary outcomes: comparison of safety profile with a matched control group in which the standard of care and the evaluation of resource optimization were maintained and economic evaluation. Results: Between July 2022 and February 2024, 48 patients were enrolled in the present study. Six patients (12.5%) dropped out due to unsatisfied discharge criteria on POD2. Exclusion causes were: significant air leaks (n:2) requiring monitoring and the use of suction device, uncontrolled pain (n:2), atrial fibrillation, and occurrence of cerebral ischemia (n:1 each). The adherence rate to vital signs monitoring by patients was 100%. A mean number of four measurements per day was performed by each patient. During telehealth home monitoring, a total of 71/2163 (1.4%) vital sign measurements violated the established acceptable threshold in 22 (52%) patients. All critical violations were managed at home. During the surveillance period (defined as the time from POD 2 to the day of chest tube removal), a persistent air leak was recorded in one patient requiring readmission to the hospital (on POD 13) and re-intervention with placement of a second thoracic drainage due to unsatisfactory lung expansion. No other postoperative complication occurred nor was there any readmission needed. Compared to the control group, the discharge gain was 2.5 days, with an economic benefit of 528 €/day (55.440 € on the total enrolled population). Conclusions: Our results confirm that the adoption of telehealth home monitoring is feasible and allows a safe discharge on postoperative day two after robotic surgery for stage I-II NSCLC in selected patients. A potential economic benefit (141 days of hospitalizations avoided) for the healthcare system could result from the adoption of this protocol.

Published
2024
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15. Comprehensive Observational and Longitudinal study on the Outbreak of Stroke-related Spasticity focusing on the Early Onset management with Botulinum NeuroToxin (COLOSSEO-BoNT): protocol for a real-world prospective observational study on upper limb spasticity.

Author

Marano M, Suppa A, Palmieri MG, Cecconi E, Frisullo G, Bovenzi R, Riso V, Anzini A, Brienza M, Anticoli S, Crupi D, Giovannelli M, Massimiani A, Rinalduzzi S, Morena E, Massara MC, Cupini L, Bressi F, Pilato F, Maggi L, Sauchelli D, Iezzi E, Centonze D, Aprile I, Di Lazzaro V, Toni D, and Altavista MC

Subjects
Female, Humans, Male, Longitudinal Studies, Observational Studies as Topic, Prospective Studies, Stroke Rehabilitation methods, Botulinum Toxins, Type A therapeutic use, Botulinum Toxins, Type A administration & dosage, Muscle Spasticity drug therapy, Muscle Spasticity etiology, Neuromuscular Agents therapeutic use, Neuromuscular Agents administration & dosage, Stroke complications, Upper Extremity physiopathology
Abstract

Introduction: Poststroke spasticity (PSS) affects up to 40% of patients who had a stroke. Botulinum neurotoxin type A (BoNT-A) has been shown to improve spasticity, but the optimal timing of its application remains unclear. While several predictors of upper limb PSS are known, their utility in clinical practice in relation to BoNT-A treatment has yet to be fully elucidated. The COLOSSEO-BoNT study aims to investigate predictors of PSS and the effects of BoNT-A timing on spasticity-related metrics in a real-world setting., Methods and Analysis: The recruitment will involve approximately 960 patients who have recently experienced an ischaemic stroke (within 10 days, V0) and will follow them up for 24 months. Parameters will be gathered at specific intervals: (V1) 4, (V2) 8, (V3) 12, (V4) 18 months and (V5) 24 months following enrolment. Patients will be monitored throughout their rehabilitation and outpatient clinic journeys and will be compared based on their BoNT-A treatment status-distinguishing between patients receiving treatment at different timings and those who undergo rehabilitation without treatment. Potential predictors will encompass the Fugl-Meyer assessment, the National Institute of Health Stroke Scale (NIHSS), stroke radiological characteristics, performance status, therapies and access to patient care pathways. Outcomes will evaluate muscle stiffness using the modified Ashworth scale and passive range of motion, along with measures of quality of life, pain, and functionality., Ethics and Dissemination: This study underwent review and approval by the Ethics Committee of the Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. Regardless of the outcome, the findings will be disseminated through publication in peer-reviewed journals and presentations at national and international conferences., Trial Registration Number: NCT05379413., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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