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16 results on '"Ceccarelli, Jacopo"'

2. Evaluation of the risk of occupational exposure to antineoplastic drugs in healthcare sector: part I – medical gloves

Author

Dugheri Stefano, Squillaci Donato, Cappelli Giovanni, Saccomando Valentina, Fanfani Niccolò, Ceccarelli Jacopo, Mucci Nicola, and Arcangeli Giulio

Subjects
alert glove values, glove contamination, glove permeation, agv, propusnost, kontaminacija, Toxicology. Poisons, RA1190-1270
Abstract

Antineoplastic drugs (ADs) are essential tools in cancer treatment, but their cytotoxicity poses a risk to workers involved in their handling. In a hospital environment fundamental strategies for minimising exposure involve proper use of safety cabinets and closed-circuit transfer devices, along with personnel training and increased awareness of risks. However, medical gloves remain the first line of defence. In this respect the evaluation of glove materials and best choices can improve hospital safety management and prevent potential hazards and long-term consequences. The aim of this study was to assess contamination of gloves in samples taken from AD administration and preparation units of nine Italian hospitals and to raise awareness of the importance of evaluating chemico-physical properties of gloves. Our findings show that 33 % of the analysed gloves were positive for at least one AD, with contaminations ranging from 0.6 to 20,729 pg/ cm2. We proposed the alert glove values (AGVs) for each AD as a limit value for contamination assessment and good practice evaluation. Our findings also point to multiple AD contamination (43 % of positive findings in preparation units), calculated as total AGV (AGV-T), and confirm that gloves should be replaced after 30 min of AD handling, based on cumulative permeation and area under the curve (AUC), to maintain safety and limit dermal exposure.

Published
2023
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3. Strategy to evaluate the impact of formaldehyde in anatomical pathology laboratory part II

Author

Dugheri, Stefano, primary, Cappelli, Giovanni, additional, Mucci, Nicola, additional, Arcangeli, Giulio, additional, Isolani, Lucia, additional, Trevisani, Lucia, additional, Squillaci, Donato, additional, Bucaletti, Elisabetta, additional, Ceccarelli, Jacopo, additional, Pettinari, Simone, additional, Amagliani, Giovanni, additional, and Fanfani, Niccolò, additional

Published
2024
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6. A New Perspective on SPME and SPME Arrow: Formaldehyde Determination by On-Sample Derivatization Coupled with Multiple and Cooling-Assisted Extractions

Author

Dugheri, Stefano, primary, Cappelli, Giovanni, additional, Fanfani, Niccolò, additional, Ceccarelli, Jacopo, additional, Marrubini, Giorgio, additional, Squillaci, Donato, additional, Traversini, Veronica, additional, Gori, Riccardo, additional, Mucci, Nicola, additional, and Arcangeli, Giulio, additional

Published
2023
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10. INNOVATIVE GAS CHROMATOGRAPHIC DETERMINATION OF FORMALDEHYDE BY MINIATURIZED EXTRACTION AND ON-FIBER DERIVATIZATION, VIA SPME AND SPME ARROW

Author

Dugheri, Stefano, Cappelli, Giovanni, Ceccarelli, Jacopo, Fanfani, Niccolò, Trevisani, Lucia, Squillaci, Donato, Bucaletti, Elisabetta, Gori, Riccardo, Mucci, Nicola, and Arcangeli, Giulio

Subjects
mass spectrometry, headspace solid-phase microextraction, gas chromatography, formaldehyde, on-fiber derivatization
Abstract

Formaldehyde (FA) is a carbonyl compound, ubiquitous in the environment and among the most widespread pollutants: it has exhibited toxic properties and is classified as a human carcinogen. FA is released from several sources, both temporary (e.g., combustion processes) and permanent (e.g., building products). This work proposes an innovative fully-automated application of headspace solid-phase microextraction (SPME) with on-fiber derivatization for the analysis of airborne FA emitted from liquid solutions or solid manufacts, in static mode, via gas chromatography-mass spectrometry. The method was tested in a wide range of airborne FA concentrations, using SPME and SPME Arrow fibers: the inter-day LOD and LOQ for SPME and SPME Arrow were evaluated, resulting in 0.072 and 0.215 ppm and 0.014 and 0.042 ppm, respectively. Moreover, other conventional detectors, such as Electron Capture Detector (ECD), Thermoionic Specific Detector (TSD), Photoionization Detector (PID), and Flame Ionization Detector (FID), were tested to set an analytical method to meet different requirements. The sensitivity and linearity of PID, FID and MS were comparable, while TSD and ECD were not suitable for the developed method, due to issues of response or linearity. MS results to be the most suitable and perfoming detector, however PID and FID result to be cheaper valid alternatives.

Published
2022

11. Nonsteroidal Anti-Inflammatory Drugs–1-Phenylethylamine Diastereomeric Salts: A Systematic Solid-State Investigation

Author

Rossi, Patrizia, primary, Ceccarelli, Jacopo, additional, Milazzo, Stella, additional, Paoli, Paola, additional, Morais Missina, Juliana, additional, Ciattini, Samuele, additional, Ienco, Andrea, additional, Tuci, Giulia, additional, Valleri, Maurizio, additional, Giovannoni, Maria Paola, additional, Guerrini, Gabriella, additional, and Conti, Luca, additional

Published
2021
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