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1. NGF and BDNF in pediatrics syndromes

Author

Ferraguti, Giampiero, Terracina, Sergio, Micangeli, Ginevra, Lucarelli, Marco, Tarani, Luigi, Ceccanti, Mauro, Spaziani, Matteo, D’Orazi, Valerio, Petrella, Carla, and Fiore, Marco

Published
2023
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2. Why haven't we solved the addiction crisis?

Author

Blum, Kenneth, Bowirrat, Abdalla, Gomez, Luis Llanos, Downs, B. William, Bagchi, Debasis, Barh, Debmalya, Modestino, Edward J., Baron, David, McLaughlin, Thomas, Thanos, Panayotis, Ceccanti, Mauro, Elman, Igor, Badgaiyan, Rajendra D., Dennen, Catherine, Gupta, Ashim, Braverman, Eric R., and Gold, Mark S.

Published
2022
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3. Identification of stress-induced epigenetic methylation onto dopamine D2 gene and neurological and behavioral consequences

Author

Blum, Kenneth, primary, Bowirrat, Abdalla, additional, Baron, David, additional, Elman, Igor, additional, Makale, Milan T., additional, Cadet, Jean Lud, additional, Thanos, Panayotis K., additional, Hanna, Colin, additional, Ahmed, Rania, additional, Gondre-Lewis, Marjorie C., additional, Dennen, Catherine A., additional, Braverman, Eric R., additional, Soni, Diwanshu, additional, Carney, Paul, additional, Khalsa, Jag, additional, Modestino, Edward J., additional, Barh, Debmalya, additional, Bagchi, Debasis, additional, Badgaiyan, Rajendra D., additional, McLaughlin, Thomas, additional, Cortese, Rene, additional, Ceccanti, Mauro, additional, Murphy, Kevin T., additional, Gupta, Ashim, additional, Makale, Miles T., additional, Sunder, Keerthy, additional, and Gold, Mark S., additional

Published
2024
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5. DNA Sequence Variations Affecting Serotonin Transporter Transcriptional Regulation and Activity: Do They Impact Alcohol Addiction?

Author

Ferraguti, Giampiero, Francati, Silvia, Codazzo, Claudia, Blaconà, Giovanna, Testino, Giancarlo, Angeloni, Antonio, Fiore, Marco, Ceccanti, Mauro, and Lucarelli, Marco

Subjects
MOLECULAR biology, GENE expression, GENETIC variation, SEROTONIN uptake inhibitors, ALCOHOLISM, SEROTONIN, INTRONS
Abstract

Genetic features of alcohol dependence have been extensively investigated in recent years. A large body of studies has underlined the important role of genetic variants not only in metabolic pathways but also in the neurobiology of alcohol dependence, mediated by the neuronal circuits regulating reward and craving. Serotonin transporter (5-HTT), encoded by the SLC6A4 gene (Solute carrier family 6-neurotransmitter transporter-member 4), is targeted by antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs) and plays a pivotal role in serotoninergic transmission; it has been associated with psychiatric diseases and alcohol dependence. Transcriptional regulation and expression of 5-HTT depend not only on epigenetic modifications, among which DNA methylation (CpG and non-CpG) is primarily involved, but also on sequence variations occurring in intron/exon regions and in untranslated regions in 5′ and 3′, being the first sequences important for the splicing machinery and the last for the binding of transcription factors and micro RNAs. This work intends to shed light on the role of sequence variations known to affect the expression or function of 5-HTT in alcohol-dependent individuals. We found a statistically significant difference in the allelic (p = 0.0083) and genotypic (p = 0.0151) frequencies of the tri-allelic polymorphism, with higher function alleles and genotypes more represented in the control population. Furthermore, we identified three haplotypes more frequent in subjects with AUD (p < 0.0001) and one more frequent in the control population (p < 0.0001). The results obtained for the tri-allelic polymorphism in alcohol dependence confirm what is already present in part of the literature. The role of haplotypes requires further studies to be clarified. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Olive polyphenols and chronic alcohol protection

Author

Petrella, Carla, primary, Ferraguti, Giampiero, additional, Tarani, Luigi, additional, Chaldakov, George N., additional, Ceccanti, Mauro, additional, Greco, Antonio, additional, Ralli, Massimo, additional, and Fiore, Marco, additional

Published
2021
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13. List of contributors

Author

Abia, Rocio, primary, Abouloifa, H., additional, Adriana, Morales-Martínez, additional, Aggarwal, Diwakar, additional, Aggarwal, Vaishali, additional, Alicia, Sánchez-Mendoza, additional, Andreadou, Ioanna, additional, Angeles-Lo´pez, Quetzalli D., additional, Argüelles, Sandro, additional, Asehraou, A., additional, Audi, Namaa, additional, Ayala, Antonio, additional, Ayoub, Nehad M., additional, Badiu, Diana, additional, Badria, Farid A., additional, Barbouti, Alexandra, additional, Batanero, Eva, additional, Batarseh, Yazan S., additional, Baumann, Leslie S., additional, Ben Salah, R., additional, Bermudez, Beatriz, additional, Blanco, Santos, additional, Borras-Linares, Isabel, additional, Brasca, M., additional, Brenes, Manuel, additional, Perez-Calabuig, Ana M., additional, Cancilla, John C., additional, Cano, Mercedes, additional, Carbone, Fabrizio, additional, Carrera-González, María Pilar, additional, Casas, Rosa, additional, Ceccanti, Mauro, additional, Chaldakov, George N., additional, Covas, María-Isabel, additional, Culeddu, Nicola, additional, Cumaoğlu, Ahmet, additional, Curiel, José Antonio, additional, Damiano, Fabrizio, additional, de Castro, Antonio, additional, de Felipe, Félix López, additional, de la Torre, Rafael, additional, de las Rivas, Blanca, additional, Deiana, Pierfrancesco, additional, Dekanski, Dragana, additional, Dettori, Sandro, additional, Di Stefano, Vita, additional, Domínguez-Vías, German, additional, Dore, Antonio, additional, D’hallewin, G., additional, El Sayed, Khalid A., additional, Elgazar, Abdullah A., additional, Emanuelli, Tatiana, additional, Ferraguti, Giampiero, additional, Filigheddu, Maria Rosaria, additional, Fiore, Marco, additional, Fitó, Montserrat, additional, Francisca, Pérez-Severiano, additional, Fujiwara, Yoko, additional, Galaris, Dimitrios, additional, García, Pedro, additional, Ghabbour, N., additional, Giudetti, Anna Maria, additional, Gnoni, Antonio, additional, Gnoni, Gabriele Vincenzo, additional, Goulas, Vlasios, additional, Greco, Antonio, additional, Guclu, Gamze, additional, Haghbeen, Kamahldin, additional, Handjani, Farhad, additional, Heydari, Mojtaba, additional, Hosseini Mazinani, Mehdi, additional, Ishikawa, Tomoko, additional, Iuliano, Luigi, additional, Joel, Jiménez-Gómez, additional, Joshi, Asavari, additional, Juan, M. Emília, additional, Jugreet, Bibi Sharmeen, additional, Kaddoumi, Amal, additional, Kailis, Stanley George, additional, Kanavaros, Panagiotis, additional, Karboune, S., additional, Kelebek, Hasim, additional, Kitsoulis, Panagiotis, additional, Kouka, Paraskevi, additional, Kouretas, Demetrios, additional, Ktari, N., additional, Kumar, Gaurav, additional, Kumar, Manoj, additional, Landete, José María, additional, Lauretti, Elisabetta, additional, Lemus-Conejo, Ana, additional, Lombardo, Luca, additional, Longo, Serena, additional, Pradana-Lopez, Sandra, additional, Lopez, Sergio, additional, Lopez-Millan, Belen, additional, López-López, Antonio, additional, Lozano-Sánchez, Jesús, additional, Madar, Zecharia, additional, Mahomoodally, Mohamad Fawzi, additional, Mañas, Mariano, additional, Martinez-Victoria, Emilio, additional, Martinez-Burgos, Maria Alba, additional, Martínez-Martos, José Manuel, additional, Masre, Siti Fathiah, additional, Medina, Eduardo, additional, Medina, Rafael, additional, Menendez, Javier A., additional, Millan-Linares, Maria C., additional, Mittal, Sonam, additional, Mohammadnejad, Parvin, additional, Molinu, Maria Giovanna, additional, Montaño, Alfredo, additional, Montserrat-de la Paz, Sergio, additional, Muñoz, Mario, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Nenadis, N., additional, Nychas, G.-J.E., additional, Ortega-García, Francisca, additional, Ortega-Gomez, Almudena, additional, Pacheco, Yolanda M., additional, Panagou, E.Z., additional, Papoti, V.T., additional, Pariente, Jose Antonio, additional, Parvizi, Mohammad Mahdi, additional, Pathak, Kaveri, additional, Peinado, M. Ángeles, additional, Peragón, Juan, additional, Petrella, Carla, additional, Čabarkapa-Pirkovic, Andrea, additional, Planas, Joana M., additional, Plastina, Pierluigi, additional, Praticò, Domenico, additional, Prieto, Isabel, additional, Rajendram, Rajkumar, additional, Ralli, Massimo, additional, Ramírez-Expósito, María Jesús, additional, Ramírez-Sánchez, Manuel, additional, Rasouli, Hassan, additional, Al Rihani, Sweilem B., additional, Rodríguez, Héctor, additional, Rodríguez-López, Paloma, additional, Rokni, Y., additional, Romero, Concepción, additional, Rosillo, Maria A., additional, Ruiz-Barba, José Luis, additional, Saalaoui, E., additional, Sacanella, Emilio, additional, Sadeer, Nabeelah Bibi, additional, Sak, Katrin, additional, Saki, Maryam, additional, Salimonti, Amelia, additional, Sánchez, Antonio-Higinio, additional, Santona, Mario, additional, Segarra, Ana Belén, additional, Segura-Carretero, Antonio, additional, Selli, Serkan, additional, Sergio, Montes, additional, Sethi, Gautam, additional, Seyedebrahimi, Seyede Sanaz, additional, Shahbaz, Mana, additional, Sharma, Dhvani, additional, Soares, Mario J, additional, Spremo-Potparević, Biljana, additional, Stark, Aliza Hannah, additional, Suroowan, Shanoo, additional, Suvarna, Vasanti, additional, Tahiri, Iasim, additional, Tarani, Luigi, additional, Tassou, C.C., additional, Topalović, Dijana, additional, Torrecilla, José S., additional, Tseti, Ioulia, additional, Tsimidou, M.Z., additional, Tsoumani, Maria, additional, Tuli, Hardeep Singh, additional, Varela, Lourdes M., additional, Veskoukis, Aristidis S., additional, Villalba, Mayte, additional, Weisberg, Edmund M., additional, Yago, Maria Dolores, additional, Yang, Euitaek, additional, Yerer, Mükerrem Betül, additional, Zanwar, Anand, additional, Zelasco, Samanta, additional, and Živković, Lada, additional

Published
2021
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14. Neurogenetics and Epigenetics of Loneliness

Author

Bowirrat, Abdalla, primary, Elman, Igor, additional, Dennen, Catherine A, additional, Gondré-Lewis, Marjorie C, additional, Cadet, Jean Lud, additional, Khalsa, Jag, additional, Baron, David, additional, Soni, Diwanshu, additional, Gold, Mark S, additional, McLaughlin, Thomas, additional, Bagchi, Debasis, additional, Braverman, Eric R, additional, Ceccanti, Mauro, additional, Thanos, Panayotis K, additional, Modestino, Edward, additional, Sunder, Keerthy, additional, Jafari, Nicole, additional, Zeine, Foojan, additional, Badgaiyan, Rajendra D, additional, Barh, Debmalya, additional, Makale, Milan, additional, Murphy, Kevin T, additional, and Blum, Kenneth, additional

Published
2023
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16. How alcohol drinking affects our genes: an epigenetic point of view

Author

Ciafre, Stefania, Carito, Valentina, Ferraguti, Giampiero, Greco, Antonio, Chaldakov, George N., Fiore, Marco, and Ceccanti, Mauro

Subjects
Alcoholism -- Physiological aspects, Gene expression -- Physiological aspects, Chromatin -- Physiological aspects, Drinking of alcoholic beverages -- Physiological aspects, Genetic research -- Physiological aspects, Methylation -- Physiological aspects, Histones -- Physiological aspects, Genes -- Physiological aspects, Epigenetic inheritance -- Physiological aspects, DNA binding proteins -- Physiological aspects, Neurophysiology -- Physiological aspects, Biological sciences
Abstract

This work highlights recent studies in epigenetic mechanisms that play a role in alcoholism, which is a complex multifactorial disorder. There is a large body of evidence showing that alcohol can modify gene expression through epigenetic processes, namely DNA methylation and nucleosomal remodeling via histone modifications. In that regard, chronic exposure to ethanol modifies DNA and histone methylation, histone acetylation, and microRNA expression. The alcohol-mediated chromatin remodeling in the brain promotes the transition from use to abuse and addiction. Unravelling the multiplex pattern of molecular modifications induced by ethanol could support the development of new therapies for alcoholism and drug addiction targeting epigenetic processes. Key words: epigenetics, alcohol metabolism, DNA methylation, histone modifications, chromatin remodeling. Ce travail met en lumiere les etudes recentes des mecanismes epigenetiques qui jouent un role dans l'alcoolisme, une maladie complexe multifactorielle. De nombreuses preuves ont montre que l'alcool peut modifier l'expression genique au moyen de processus epigenetiques, a savoir la methylation d'ADN et le remodelage nucleosomique par les modifications d'histones. Dans cette veine, l'exposition chronique a l'alcool modifie l'ADN et la methylation des histones, l'acetylation des histones et l'expression de microARN. Le remodelage de la chromatine medie par l'alcool dans le cerveau favorise la transition de l'usage vers l'abus et la dependance. La resolution du patron multiplexe des modifications moleculaires induites par l'alcool implique la capacite de developper de nouvelles therapies de l'alcoolisme et de la dependance aux drogues qui ciblent les processus epigenetiques. [Traduit par la Redaction] Mots-cles: epigenetique, metabolisme de l'alcool, methylation d'ADN, modifications d'histones, remodelage de la chromatine., Introduction Revealing the action of alcohol at the molecular level means a better understanding of the effects of alcohol on behavior (Ceccanti et al. 2015a, 2018a, 2018b; Coriale et al. [...]

Published
2019
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17. Erratum to Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey American Journal of Obstetrics & Gynecology MFM. Volume 5, Issue 6, June 2023, 100944

Author

La Maida, Nunzia, primary, Di Giorgi, Alessandro, additional, Pellegrini, Manuela, additional, Ceccanti, Mauro, additional, Caruso, Salvatore, additional, Ricci, Giuseppe, additional, Neri, Isabella, additional, Lana, Sheherazade, additional, Minutillo, Adele, additional, Berretta, Paolo, additional, Busardò, Francesco Paolo, additional, and Pichini, Simona, additional

Published
2023
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18. The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study

Author

Fiore, Marco, primary, Minni, Antonio, additional, Cavalcanti, Luca, additional, Raponi, Giammarco, additional, Puggioni, Gianluca, additional, Mattia, Alessandro, additional, Gariglio, Sara, additional, Colizza, Andrea, additional, Meliante, Piero Giuseppe, additional, Zoccali, Federica, additional, Tarani, Luigi, additional, Barbato, Christian, additional, Lucarelli, Marco, additional, Ceci, Flavio Maria, additional, Francati, Silvia, additional, Ferraguti, Giampiero, additional, Ceccanti, Mauro, additional, and Petrella, Carla, additional

Published
2023
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19. Oxidative Stress in a Mother Consuming Alcohol during Pregnancy and in Her Newborn: A Case Report

Author

Derme, Martina, primary, Piccioni, Maria Grazia, additional, Brunelli, Roberto, additional, Crognale, Alba, additional, Denotti, Marika, additional, Ciolli, Paola, additional, Scomparin, Debora, additional, Tarani, Luigi, additional, Paparella, Roberto, additional, Terrin, Gianluca, additional, Di Chiara, Maria, additional, Mattia, Alessandro, additional, Nicotera, Simona, additional, Salomone, Alberto, additional, Ceccanti, Mauro, additional, Messina, Marisa Patrizia, additional, Maida, Nunzia La, additional, Ferraguti, Giampiero, additional, Petrella, Carla, additional, and Fiore, Marco, additional

Published
2023
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20. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author

La Maida, Nunzia, primary, Di Giorgi, Alessandro, additional, Pellegrini, Manuela, additional, Ceccanti, Mauro, additional, Caruso, Salvatore, additional, Ricci, Giuseppe, additional, Neri, Isabella, additional, Lana, Sheherazade, additional, Minutillo, Adele, additional, Berretta, Paolo, additional, Busardò, Francesco Paolo, additional, Pichini, Simona, additional, Camandona, Franco, additional, Vaccari, Lucia, additional, Travan, Laura, additional, Maso, Giampaolo, additional, Stampalija, Tamara, additional, Zanazzo, Lucia, additional, Pisana, Paola, additional, Driul, Lorenza, additional, Barbui, Elisa, additional, Caissutti, Claudia, additional, Valente, Elena, additional, Ricchi, Alba, additional, Bettiga, Elisa, additional, Piccolo, Elisa, additional, Pati, Mariangela, additional, Pedori, Simona, additional, Antonazzo, Patrizio, additional, Sottile, Gilda, additional, Faro, Fabrizio Lo, additional, Tini, Anastasio, additional, Massacesi, Mario, additional, Rapisarda, Carmen, additional, Vivirito, Gabriella, additional, Pinna, Giampiero, additional, D'anna, Mariarosa, additional, Klein, Lili, additional, Bucolo, Antonino, additional, D'Anna, Rosario, additional, Monaco, Caterina, additional, La Ferrera, Giuseppe, additional, Capobianco, Giampiero, additional, Olzai, Mauro Giorgio, additional, Angioni, Stefano, additional, D'Alterio, Maurizio Nicola, additional, Serravalle, Paolo, additional, Vicquéry, Christine, additional, Scalchi, Sabrina, additional, Morando, Carla, additional, Meneghin, Margherita, additional, Scapolan, Cinzia, additional, Maggino, Tiziano, additional, Guarinoni, Barbara, additional, Napolitano, Giovanna M. Cristina, additional, De Vita, Maria Grazia, additional, Carlo, Costantino Di, additional, Interlandi, Fabiana, additional, Bisceglia, Massimo, additional, Barbaglia, Michelangelo, additional, Arnulfo, Alberto, additional, Finale, Enrico, additional, Marozio, Luca, additional, Natali, Ilaria, additional, Grazia, Signoretti Maria, additional, Staffler, Alex, additional, Tarani, Luigi, additional, Coriale, Giovanna, additional, Messina, Marisa Patrizia, additional, D'Angelo, Alessio, additional, Bonito, Marco, additional, Haass, Cristina, additional, Capasso, Letizia, additional, Raimondi, Francesco, additional, De Bernardo, Giuseppe, additional, Iacobelli, Pietro, additional, Spadarella, Simona, additional, Mastantuoni, Enrica, additional, Rabuano, Raffaello, additional, Calzatini, Francesco, additional, Bossi, Anna, additional, Aversa, Salvatore, additional, Prefumo, Federico, additional, Bellan, Cristina, additional, Leone, Giovanna, additional, Ciammella, Massimo, additional, Von-Wunster, Silvia, additional, Liguori, Antonella, additional, Ornaghi, Sara, additional, Fumagalli, Simona, additional, Sanguineti, Fabio, additional, Gianola, Gaia, additional, Cagnacci, Angelo, additional, Amidani, Arianna, additional, Sisto, Antonio, additional, Marcello, Francesca Di, additional, Santillo, Vincenzo, additional, Bartolomeo, Cristina Di, additional, Gerli, Sandro, additional, Cagnoli, Giacomo, additional, Petrisano, Mirella, additional, Pesce, Simona, additional, Lascio, Nicola Di, additional, Falvino, Sonia, additional, Appio, Petronilla, additional, Targiani, Vincenza, additional, Cavaliere, Anna Franca, additional, Turrini, Irene, additional, Belli, Gilda, additional, Gambi, Beatrice, additional, Florio, Pasquale, additional, Innocenti, Elena Degli, additional, Magi, Letizia, additional, Civitelli, Flavio, additional, Nappi, Luigi, additional, Sorrentino, Felice, additional, Silvestris, Teresa, additional, Indrio, Flavia, additional, Laforgia, Nicola, additional, Rizzo, Valentina, additional, La Rocca, Maria, additional, Pradal, Ugo, additional, Memo, Luigi, additional, Diaz, Claudio, additional, Riscica, Patrizia, additional, and Bazz, Stefania, additional

Published
2023
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23. Serum Lipocalin-2 Levels as a Biomarker in Pre- and Post-Pubertal Klinefelter Syndrome Patients: A Pilot Study.

Author

Paparella, Roberto, Ferraguti, Giampiero, Fiore, Marco, Menghi, Michela, Micangeli, Ginevra, Tarani, Francesca, Ligotino, Aurora, Messina, Marisa Patrizia, Ceccanti, Mauro, Minni, Antonio, Barbato, Christian, Lucarelli, Marco, Tarani, Luigi, and Petrella, Carla

Subjects
KLINEFELTER'S syndrome, LIPOCALIN-2, INHIBIN, X chromosome, PILOT projects, ENDOCRINE diseases, CHOLESTERYL ester transfer protein, SERUM
Abstract

Klinefelter syndrome (KS) is a male genetic disease caused by the presence of an extra X chromosome, causing endocrine disorders mainly responsible for a high rate of infertility and metabolic disorders in adulthood. Scientific research is interested in identifying new biomarkers that can be predictive or prognostic of alterations strictly connected to KS. Lipocalin-2 (LCN-2, also known as NGAL) is a small protein initially identified within neutrophils as a protein related to innate immunity. Serum LCN-2 estimation seems to be a useful tool in predicting the metabolic complications caused by several pathological conditions. However, little is known about its potential role in infertility conditions. The present pilot study aims to investigate the presence of LCN-2 in the serum of a group of pre-pubertal and post-pubertal children affected by KS, compared to healthy controls. We demonstrated for the first time the presence of elevated levels of LCN-2 in the serum of KS patients, compared to controls. This increase was accompanied, in pre-pubertal KS patients, by the loss of correlation with LH and HDL, which instead was present in the healthy individuals. Moreover, in all KS individuals, a positive correlation between LCN-2 and inhibin B serum concentration was found. Despite the limited size of the sample analyzed, our preliminary data encourage further studies to confirm the findings and to extend the study to KS adult patients, to verify the predictive/prognostic value of LCN-2 as new biomarker for metabolic diseases and infertility associated with the pathology. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Virtual Morris task responses in individuals in an abstinence phase from alcohol

Author

Ceccanti, Mauro, Coriale, Giovanna, Hamilton, Derek A., Carito, Valentina, Coccurello, Roberto, Scalese, Bruna, Ciafre, Stefania, Codazzo, Claudia, Messina, Marisa Patrizia, Chaldakov, George N., and Fiore, Marco

Subjects
Sex differences (Psychology) -- Comparative analysis, Detoxification (Substance abuse treatment) -- Comparative analysis, Spatial ability -- Comparative analysis, Human spatial behavior -- Comparative analysis, Biological sciences
Abstract

The present study was aimed at examining spatial learning and memory, in 33 men and 12 women with alcohol use disorder (AUD) undergoing ethanol detoxification, by using a virtual Morris task. As controls, we recruited 29 men and 10 women among episodic drinkers without a history of alcohol addiction or alcohol-related diseases. Elevated latency to the first movement in all trials was observed only in AUD persons; furthermore, control women had longer latencies compared with control men. Increased time spent to reach the hidden platform in the learning phase was found for women of both groups compared with men, in particular during trial 3. As predicted, AUD persons (more evident in men) spent less time in the target quadrant during the probe trial; however, AUD women had longer latencies to reach the platform in the visible condition during trials 6 and 7 that resulted in a greater distance moved. As for the probe trial, men of both groups showed increased virtual locomotion compared with the women of both groups. The present investigation confirms and extends previous studies showing (i) different gender responses in spatial learning tasks, (ii) some alterations due to alcohol addiction in virtual spatial learning, and (iii) differences between AUD men and AUD women in spatial-behaviour-related paradigms. Key words: alcoholism, virtual Morris task, gender, cognition, spatial memory. Les presents travaux visaient a etudier a l'aide d'une tache de Morris virtuelle l'apprentissage et la memoire spatiales chez 33 hommes et 12 femmes presentant des troubles lies a la consommation d'alcool (TCA) suivant une cure de desintoxication de l'ethanol. Comme temoins, nous avons inscrit 29 hommes et 10 femmes parmi des buveurs episodiques sans antecedents d'alcoolisme ni de maladies liees a l'alcool. Nous avons observe une augmentation de la latence avant le premier mouvement uniquement dans le groupe TCA. En outre, les temoins feminins presentaient des latences plus longues que les temoins masculins. Nous avons aussi observe au cours de la phase d'apprentissage que le temps ecoule avant de rejoindre la plateforme cachee etait plus eleve chez les femmes des deux groupes que chez les hommes, en particulier au cours de l'essai 3. Comme prevu les personnes atteintes de TCA (plus evident chez les hommes) ont passe moins de temps dans le quadrant cible pendant l'essai de sonde, mais les femmes atteintes de TCA presentaient de plus longues latences avant d'atteindre la plateforme en conditions de visibilite au cours des essais 6 et 7, ce qui s'est traduit par une plus grande distance de deplacement. Quant a l'essai de sonde, les hommes des deux groupes ont presente une augmentation de la locomotion virtuelle par rapport aux femmes des deux groupes. La presente etude confirme et elargit les observations d'etudes precedentes montrant (i) des reactions differentes selon le sexe quant aux taches d'apprentissage spatial, (ii) certaines modifications causees par l'alcoolisme quant a l'apprentissage spatial virtuel, et (iii) des differences entre les hommes et les femmes atteints de TCA quant aux paradigmes lies aux comportements spatiaux. [Traduit par la Redaction] Mots-cles: alcoolisme, tache de Morris virtuelle, sexe, facultes cognitives, memoire spatiale., Introduction Heavy alcohol consumption is known to be associated with changes across several domains of cognition, including executive functioning and memory domains (Oscar-Berman and Marinkovic 2003, 2007). Indeed in alcoholics, [...]

Published
2018
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26. Neurogenetics and Epigenetics of Loneliness

Author

Bowirrat,Abdalla, Elman,Igor, Dennen,Catherine A, Gondré-Lewis,Marjorie C, Cadet,Jean Lud, Khalsa,Jag, Baron,David, Soni,Diwanshu, Gold,Mark S, McLaughlin,Thomas, Bagchi,Debasis, Braverman,Eric R, Ceccanti,Mauro, Thanos,Panayotis K, Modestino,Edward, Sunder,Keerthy, Jafari,Nicole, Zeine,Foojan, Badgaiyan,Rajendra D, Barh,Debmalya, Makale,Milan, Murphy,Kevin T, Blum,Kenneth, Bowirrat,Abdalla, Elman,Igor, Dennen,Catherine A, Gondré-Lewis,Marjorie C, Cadet,Jean Lud, Khalsa,Jag, Baron,David, Soni,Diwanshu, Gold,Mark S, McLaughlin,Thomas, Bagchi,Debasis, Braverman,Eric R, Ceccanti,Mauro, Thanos,Panayotis K, Modestino,Edward, Sunder,Keerthy, Jafari,Nicole, Zeine,Foojan, Badgaiyan,Rajendra D, Barh,Debmalya, Makale,Milan, Murphy,Kevin T, and Blum,Kenneth

Abstract

Abdalla Bowirrat,1 Igor Elman,2 Catherine A Dennen,3 Marjorie C Gondré-Lewis,4 Jean Lud Cadet,5 Jag Khalsa,6 David Baron,7 Diwanshu Soni,8 Mark S Gold,9 Thomas J McLaughlin,10 Debasis Bagchi,11 Eric R Braverman,12 Mauro Ceccanti,13 Panayotis K Thanos,14,15 Edward Justin Modestino,16 Keerthy Sunder,17,18 Nicole Jafari,19,20 Foojan Zeine,21,22 Rajendra D Badgaiyan,23 Debmalya Barh,24,25 Milan Makale,26 Kevin T Murphy,27 Kenneth Blum1,7,10,12,18,20,24,28,29 1Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, 40700, Israel; 2Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, 02139, USA; 3Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, USA; 4Neuropsychopharmacology Laboratory, Department of Anatomy, Howard University College of Medicine, Washington, DC, 20059, USA; 5Molecular Neuropsychiatry Research Branch, NIH National Institute on Drug Abuse, Bethesda, MD, 20892, USA; 6Department of Microbiology, Immunology and Tropical Medicine, George Washington University, School of Medicine, Washington, DC, USA; 7Division of Addiction Research & Education, Center for Sports, Exercise, and Mental Health, Western University of Health Sciences, Pomona, CA, 91766, USA; 8Western University Health Sciences School of Medicine, Pomona, CA, USA; 9Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA; 10Division of Reward Deficiency Clinics, TranspliceGen Therapeutics, Inc, Austin, TX, USA; 11Department of Pharmaceutical Sciences, Texas Southern University College of Pharmacy, Houston, TX, USA; 12Division of Clinical Neurology, The Kenneth Blum Institute of Neurogenetics & Behavior, LLC, Austin, TX, USA; 13Alcohol Addiction Program, Latium Region Referral Center, Sapienza University of Rome, Roma, 00185, Italy; 14Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicolo

Published
2023

27. Investigating Biomarkers for COVID-19 Morbidity and Mortality

Author

Fiore, Marco, primary, Ceci, Flavio Maria, additional, Ferraguti, Giampiero, additional, Lucarelli, Marco, additional, Angeloni, Antonio, additional, Bonci, Enea, additional, Petrella, Carla, additional, Francati, Silvia, additional, Barbato, Christian, additional, Di Certo, Maria Grazia, additional, Gabanella, Francesca, additional, Gavaruzzi, Francesca, additional, Mastroianni, Claudio Maria, additional, Minni, Antonio, additional, Greco, Antonio, additional, Ralli, Massimo, additional, Ceccanti, Mauro, additional, and Tarani, Luigi, additional

Published
2023
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28. Characteristic Hallmarks of Aging and the Impact on Carcinogenesis

Author

Fiore, Marco, primary, Terracina, Sergio, additional, Ferraguti, Giampiero, additional, Petrella, Carla, additional, Bruno, Sabina Maria, additional, Blaconà, Giovanna, additional, Di Certo, Maria Grazia, additional, Minni, Antonio, additional, Greco, Antonio, additional, Musacchio, Angela, additional, Ralli, Massimo, additional, Tarani, Luigi, additional, Ceccanti, Mauro, additional, Polimeni, Antonella, additional, and Triaca, Viviana, additional

Published
2023
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30. Invited Expert Opinion- Bio-informatic and Limitation Di-rectives to Help Adopt Ge-netic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Re-quired Analytic Evidence to Induce Dopamine Homeo-statsis

Author

Blum, Kenneth, primary, Gold, Mark, additional, Cadet, Jean, additional, Lewis, Marjorie, additional, McLaughlin, Thomas, additional, Braverman, Eric, additional, Elman, Igor, additional, Carney, B. Paul, additional, Cortese, Rene, additional, Abijo, Tomilowo, additional, Bagchi, Debasis, additional, Giordano, John, additional, Dennen, Catherine, additional, Baron, David, additional, Thanos, Panayotis, additional, Soni, Diwanshu, additional, Makale, Milan, additional, Makale, Miles, additional, Murphy, Kevin, additional, Jafari, Nicole, additional, Sunder, Keerthy, additional, Zeine, Foojan, additional, Ceccanti, Mauro, additional, Bowirrat, Abdalla, additional, and Badgaiyan, Rajendra, additional

Published
2023
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31. Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids

Author

Ceccanti, Mauro, primary, Blum, Kenneth, additional, Bowirrat, Abdalla, additional, Dennen, Catherine A., additional, Braverman, Eric R., additional, Baron, David, additional, Mclaughlin, Thomas, additional, Giordano, John, additional, Gupta, Ashim, additional, Downs, Bernard W., additional, Bagchi, Debasis, additional, Barh, Debmalya, additional, Elman, Igor, additional, Thanos, Panayotis K., additional, Badgaiyan, Rajendra D., additional, Edwards, Drew, additional, and Gold, Mark S., additional

Published
2022
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32. Cancer screenings among sexual and gender minorities by midwives' point of view

Author

MESSINA, Marisa P., primary, D’ANGELO, Alessio, additional, GIOVAGNOLI, Rebecca, additional, NAPOLITANO, Monica, additional, PETRELLA, Carla, additional, RALLI, Massimo, additional, GRECO, Antonio, additional, CAVALCANTI, Luca, additional, RICCHI, Alba, additional, NERI, Isabella, additional, DE PERSIS, Simone, additional, FIORE, Marco, additional, and CECCANTI, Mauro, additional

Published
2022
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33. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author

Camandona, Franco, Vaccari, Lucia, Travan, Laura, Maso, Giampaolo, Stampalija, Tamara, Zanazzo, Lucia, Pisana, Paola, Driul, Lorenza, Barbui, Elisa, Caissutti, Claudia, Valente, Elena, Ricchi, Alba, Bettiga, Elisa, Piccolo, Elisa, Pati, Mariangela, Pedori, Simona, Antonazzo, Patrizio, Sottile, Gilda, Faro, Fabrizio Lo, Tini, Anastasio, Massacesi, Mario, Rapisarda, Carmen, Vivirito, Gabriella, Pinna, Giampiero, D'anna, Mariarosa, Klein, Lili, Bucolo, Antonino, D'Anna, Rosario, Monaco, Caterina, La Ferrera, Giuseppe, Capobianco, Giampiero, Olzai, Mauro Giorgio, Angioni, Stefano, D'Alterio, Maurizio Nicola, Serravalle, Paolo, Vicquéry, Christine, Scalchi, Sabrina, Morando, Carla, Meneghin, Margherita, Scapolan, Cinzia, Maggino, Tiziano, Guarinoni, Barbara, Napolitano, Giovanna M. Cristina, De Vita, Maria Grazia, Carlo, Costantino Di, Interlandi, Fabiana, Bisceglia, Massimo, Barbaglia, Michelangelo, Arnulfo, Alberto, Finale, Enrico, Marozio, Luca, Natali, Ilaria, Grazia, Signoretti Maria, Staffler, Alex, Tarani, Luigi, Coriale, Giovanna, Messina, Marisa Patrizia, D'Angelo, Alessio, Bonito, Marco, Haass, Cristina, Capasso, Letizia, Raimondi, Francesco, De Bernardo, Giuseppe, Iacobelli, Pietro, Spadarella, Simona, Mastantuoni, Enrica, Rabuano, Raffaello, Calzatini, Francesco, Bossi, Anna, Aversa, Salvatore, Prefumo, Federico, Bellan, Cristina, Leone, Giovanna, Ciammella, Massimo, Von-Wunster, Silvia, Liguori, Antonella, Ornaghi, Sara, Fumagalli, Simona, Sanguineti, Fabio, Gianola, Gaia, Cagnacci, Angelo, Amidani, Arianna, Sisto, Antonio, Marcello, Francesca Di, Santillo, Vincenzo, Bartolomeo, Cristina Di, Gerli, Sandro, Cagnoli, Giacomo, Petrisano, Mirella, Pesce, Simona, Lascio, Nicola Di, Falvino, Sonia, Appio, Petronilla, Targiani, Vincenza, Cavaliere, Anna Franca, Turrini, Irene, Belli, Gilda, Gambi, Beatrice, Florio, Pasquale, Innocenti, Elena Degli, Magi, Letizia, Civitelli, Flavio, Nappi, Luigi, Sorrentino, Felice, Silvestris, Teresa, Indrio, Flavia, Laforgia, Nicola, Rizzo, Valentina, La Rocca, Maria, Pradal, Ugo, Memo, Luigi, Diaz, Claudio, Riscica, Patrizia, Bazz, Stefania, La Maida, Nunzia, Di Giorgi, Alessandro, Pellegrini, Manuela, Ceccanti, Mauro, Caruso, Salvatore, Ricci, Giuseppe, Neri, Isabella, Lana, Sheherazade, Minutillo, Adele, Berretta, Paolo, Busardò, Francesco Paolo, and Pichini, Simona

Published
2023
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35. Genetic Addiction Risk Severity Assessment Identifies Polymorphic Reward Genes as Antecedents to Reward Deficiency Syndrome (RDS) Hypodopaminergia’s Effect on Addictive and Non-Addictive Behaviors in a Nuclear Family

Author

Dennen, Catherine A., primary, Blum, Kenneth, additional, Bowirrat, Abdalla, additional, Thanos, Panayotis K., additional, Elman, Igor, additional, Ceccanti, Mauro, additional, Badgaiyan, Rajendra D., additional, McLaughlin, Thomas, additional, Gupta, Ashim, additional, Bajaj, Anish, additional, Baron, David, additional, Downs, B. William, additional, Bagchi, Debasis, additional, and Gold, Mark S., additional

Published
2022
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36. Markers of Neuroinflammation in the Serum of Prepubertal Children with Fetal Alcohol Spectrum Disorders

Author

Fiore, Marco, primary, Petrella, Carla, additional, Coriale, Giovanna, additional, Rosso, Pamela, additional, Fico, Elena, additional, Ralli, Massimo, additional, Greco, Antonio, additional, De Vincentiis, Marco, additional, Minni, Antonio, additional, Polimeni, Antonella, additional, Vitali, Mario, additional, Messina, Marisa Patrizia, additional, Ferraguti, Giampiero, additional, Tarani, Francesca, additional, de Persis, Simone, additional, Ceccanti, Mauro, additional, and Tarani, Luigi, additional

Published
2022
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37. Reward Deficiency Syndrome Model of Addiction Psychiatry: Everywhere, Everything, and All at Once

Author

Blum, Kenneth, primary, Bowirrat, Abdalla, additional, Ceccanti, Mauro, additional, Dennen, Catherine, additional, McLaughlin, Thomas, additional, Baron, David, additional, Elman, Igor, additional, Braverman, Eric R, additional, Gold, Mark S, additional, Gupta, Ashim, additional, Thanos, Panayotis K, additional, Gastelu, Daniel, additional, and Badgaiyan, Rajendra D, additional

Published
2022
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38. The Impact of Oxidative Stress on Pediatrics Syndromes

Author

Micangeli, Ginevra, primary, Menghi, Michela, additional, Profeta, Giovanni, additional, Tarani, Francesca, additional, Mariani, Alessandro, additional, Petrella, Carla, additional, Barbato, Christian, additional, Ferraguti, Giampiero, additional, Ceccanti, Mauro, additional, Tarani, Luigi, additional, and Fiore, Marco, additional

Published
2022
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39. Correction: Messina et al. Knowledge and Practice towards Alcohol Consumption in a Sample of University Students. Int. J. Environ. Res. Public Health 2021, 18, 9528

Author

Messina, Marisa Patrizia, primary, Battagliese, Gemma, additional, D’Angelo, Alessio, additional, Ciccarelli, Rosaria, additional, Pisciotta, Fabiola, additional, Tramonte, Luigi, additional, Fiore, Marco, additional, Ferraguti, Giampiero, additional, Vitali, Mario, additional, and Ceccanti, Mauro, additional

Published
2022
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40. Transgenerational Abnormalities Induced by Paternal Preconceptual Alcohol Drinking: Findings from Humans and Animal Models

Author

Terracina, Sergio, primary, Ferraguti, Giampiero, additional, Tarani, Luigi, additional, Messina, Marisa Patrizia, additional, Lucarelli, Marco, additional, Vitali, Mario, additional, De Persis, Simone, additional, Greco, Antonio, additional, Minni, Antonio, additional, Polimeni, Antonella, additional, Ceccanti, Mauro, additional, Petrella, Carla, additional, and Fiore, Marco, additional

Published
2022
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42. Deep TMS on alcoholics: effects on cortisolemia and dopamine pathway modulation. A pilot study

Author

Ceccanti, Marco, Inghilleri, Maurizio, Attilia, Maria Luisa, Raccah, Ruggero, Fiore, Marco, Zangen, Abraham, and Ceccanti, Mauro

Subjects
Dopamine -- Health aspects, Drug-alcohol interactions -- Identification and classification, Alcoholics -- Health aspects, Neural stimulation -- Health aspects, Biological sciences
Abstract

The hypothalamic pituitary adrenal axis and dopamine have a key role in transition from alcohol social use to addiction. The medial prefrontal cortex was shown to modulate dopaminergic activity and cortisol releasing factor (CRF) release in hypothalamic and extra-hypothalamic systems. The recent advancements in non-invasive neurostimulation technologies has enabled stimulation of deeper brain regions using H-coil transcranial magnetic stimulation (TMS) in humans. This randomized double-blind placebo-controlled pilot study aims to evaluate H-coil efficacy in stimulating the medial prefrontal cortex. Cortisolemia and prolactinemia were evaluated as effectiveness markers. Alcohol intake and craving were considered as secondary outcomes. Eighteen alcoholics were recruited and randomized into 2 homogeneous groups: 9 in the real stimulation group and 9 in the sham stimulation group. Repetitive TMS (rTMS) was administered through a magnetic stimulator over 10 sessions at 20 Hz, directed to the medial prefrontal cortex. rTMS significantly reduced blood cortisol levels and decreased prolactinemia, thus suggesting dopamine increase. Craving visual analogic scale (VAS) in treated patients decreased, as well as mean number of alcoholic drinks/day and drinks on days of maximum alcohol intake (DMAI). In the sham group there was no significant effect observed on cortisolemia, prolactinemia, mean number of alcoholic drinks/day, or drinks/DMAI. Thus, deep rTMS could be considered a potential new treatment for alcoholism. Key words: alcohol, prefrontal cortex, transcranic magnetic stimulation, cortisol, prolactin. L'axe hypothalamo-hypophyso-surrenalien et la dopamine jouent un role cle dans la transition d'une consommation sociale d'alcool vers une dependance a l'alcool. Le cortex prefrontal interne module l'activite dopaminergique et la liberation de corticoliberine (CRF) dans les systemes hypothalamique et extra-hypothalamique. Un progres recent sur le plan des technologies de neurostimulation non-invasive permet de stimuler ces regions profondes du cerveau a l'aide de la stimulation magnetique trans-cranienne (SMT) chez l'humain. Cet essai pilote aleatoire a double aveugle comparatif avec placebo visait a evaluer l'efficacite de stimulation du cortex prefrontal interne de la bobine solenoide. La cortisolemie et la prolactinemie ont ete evaluees en tant que marqueurs d'efficacite. La consommation d'alcool et l'etat de besoin ont ete consideres comme resultats secondaires. Dix-huit personnes alcooliques ont ete recrutees et reparties de maniere aleatoire en deux groupes homogenes, 9 personnes avec stimulation reelle et 9 personnes avec stimulation simulee. La STM repetitive (STMr) a ete appliquee au moyen d'un stimulateur magnetique en 10 sessions de 20 Hz, et dirigee sur le cortex prefrontal interne. La STMr pouvait reduire significativement le niveau de cortisol sanguin et la prolactinemie, suggerant ainsi un accroissement de la dopamine. L'echelle visuelle de l'etat de besoin chez les patients traites diminuait, de meme que le nombre moyen de consommations par jour et le nombre de consommations lors des jours de consommation d'alcool maximale. Chez le groupe simule, aucun effet significatif n'etait observe sur la cortisolemie, la prolactinemie, le nombre moyen de consommations par jour et le nombre de consommations lors des jours de consommation maximale. Le STMr profonde pourrait etre consideree comme un outil supplementaire pour traiter l'alcoolisme. [Traduit par la Redaction] Mots-cles : alcool, cortex prefrontal, stimulation magnetique trans-cranienne, cortisol, prolactine., Introduction Background Impulse-control disorders and antisocial personality disorders are very common in patients affected by substance dependence, particularly alcoholics (Hasin et al. 2011; Lewis 2011). In the context of alcohol [...]

Published
2015
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45. List of Contributors

Author

Abbas, Ghulam, primary, Adamowicz, Piotr, additional, Adan, Ana, additional, Agay, Nirit, additional, Al-Halabí, S., additional, Altun, Hatice, additional, Amini, Maryam, additional, Andersen, Monica L., additional, Andreassen, Cecilie Schou, additional, Anthony, James C., additional, Ardakani, Yalda Hosseinzadeh, additional, Aromatario, Mariarosaria, additional, Arun, Priti, additional, Atik, Anzari, additional, Atti, Anna Rita, additional, Baird, Alison L., additional, Balconi, Michela, additional, Ballóková, Anna Lukačišinová, additional, Bascarán, M.T., additional, Battagliese, Gemma, additional, Benaiges, Irina, additional, Bergen-Cico, Dessa, additional, Berrettini, Wade H., additional, Berro, Laís F., additional, Bertol, Elisabetta, additional, Bian, Jin-Song, additional, Bobes-Bascarán, M.T., additional, Bobes, J., additional, Bocarsly, Miriam E., additional, Bocca, Marie-Laure, additional, Bonafede, Roberta, additional, Borroto-Escuela, Dasiel O., additional, Bottoni, Edoardo, additional, Bousoño, M., additional, Bowen, Michael T., additional, Bramanti, Placido, additional, Buck, Kari J., additional, Buisman-Pijlman, Femke T.A., additional, Büttner, Andreas, additional, Calabrò, Rocco S., additional, Çamsari, Ulaş M., additional, Cappelletti, Simone, additional, Carbo-Gas, María, additional, Casadio, Paola, additional, Casadó-Anguera, Verònica, additional, Casadó, Vicent, additional, Ceccanti, Mauro, additional, Chang, Yong-Yuan, additional, Chang, Young-Tae, additional, Chiu, Meng-Chun, additional, Chiu, Nan-Ying, additional, Cho, Zang-Hee, additional, Chung, Yemina, additional, Ciallella, Costantino, additional, Cinosi, Eduardo, additional, Conigrave, Katherine M., additional, Coogan, Andrew N., additional, Coppola, Maurizio, additional, Cortés, Antoni, additional, Costa, Giulia, additional, Cox, Stephen, additional, Dafny, Nachum, additional, Das, Subhash, additional, Davis, Jonathan M., additional, De Matteo, Robert, additional, Demetrovics, Zsolt, additional, Demirkol, Apo, additional, Denovan-Wright, Eileen M., additional, di Giannantonio, Massimo, additional, Edgunlu, Tuba, additional, Elliott, Simon, additional, Enman, Nicole M., additional, Ensafi, Ali A., additional, Faccini, Marco, additional, Falls, Brian A., additional, Fang, Chiu-Ping, additional, Fan, Lir-Wan, additional, Farooq, Ahsana Dar, additional, Feingold, Daniel, additional, Ferraro, Luca, additional, Fialová, Daniela, additional, Filip, Malgorzata, additional, Findikli, Ebru, additional, Finocchiaro, Roberta, additional, Fiore, Paola A., additional, Font-Mayolas, Sílvia, additional, Fox, Jonah, additional, Fragou, Domniki, additional, Fu, Qiang, additional, Fuxe, Kjell, additional, Gahr, Maximilian, additional, García-Portilla, M.P., additional, George, Preeta, additional, Gil-Miravet, Isis, additional, Gorwood, Philip, additional, Gras, Maria Eugènia, additional, Gravielle, María Clara, additional, Griffiths, Mark D., additional, Haber, Paul S., additional, Hadad, Natalie A., additional, Hall, F. Scott, additional, Han, Doug Hyun, additional, Harding, Richard, additional, Hashmi, Rida, additional, Hassanian-Moghaddam, Hossein, additional, Hernández-Serrano, Olga, additional, Herrmann, Evan S., additional, Herzog, Thaddeus A., additional, Heydari-Bafrooei, Esmaeil, additional, Hirota, Kiichi, additional, Ho, Ming-Chou, additional, Howell, Leonard L., additional, Hsu, Wen-Yu, additional, Huang, Chieh-Liang, additional, Hughes, Robert N., additional, Hymel, Kristen A., additional, Hyun, Gi Jung, additional, Inoue, Koichi, additional, Islam, M. Mofizul, additional, Jamali, Bardia, additional, Jerzemowska, Grażyna, additional, Job, Martin O., additional, Johannessen, Jan Olav, additional, Johansen, Helen J., additional, Johnson, Matthew W., additional, Johnson, Patrick S., additional, Kang, Chang-Ki, additional, Karakaş-Çelik, Sevim, additional, Kharas, Natasha, additional, Kim, Young-Bo, additional, Knackstedt, Lori A., additional, Kokki, Hannu, additional, Kokki, Merja, additional, Konopka, Anna, additional, Kopcza, Kathleen, additional, Kouvelas, Dimitrios, additional, Kovatsi, Leda, additional, Kruse, Lauren C., additional, Lai, Chien-Wen, additional, Lapeyre-Mestre, Maryse, additional, Lauterbach, Edward C., additional, Le Strat, Yann, additional, Lee, Chen-Yi, additional, Lejoyeux, Michel, additional, Leone, Roberto, additional, Lev-Ran, Shaul, additional, Li, Ren-Hau, additional, Liang, Willmann, additional, Liu, Jiajun, additional, Liu, Ling-Jun, additional, Liu, Liwei, additional, Liu, Sheng-Wen, additional, Liu, Yu-Li, additional, Li, Zia, additional, Lobo, Daniela S.S., additional, Lou, Jingsheng, additional, Luigi Picci, Rocco, additional, Lupi, Matteo, additional, Lutz, Brianna M., additional, MacClurg, Kendra, additional, Magro, Lara, additional, Manchia, Mirko, additional, Maraz, Aniko, additional, Martin-Fardon, Rémi, additional, Martinotti, Giovanni, additional, Matzeu, Alessandra, additional, McLaughlin, Jay P., additional, McRae, Ian S., additional, Meyerhoff, Dieter J., additional, Miquel, Marta, additional, Mondola, Raffaella, additional, Moore, Robert, additional, Morelli, Micaela, additional, Moreno, Estefanía, additional, Mori, Tomohisa, additional, Murnion, Bridin, additional, Murphy, Kelle L., additional, Nagpure, Bhushan Vijay, additional, Naro, Antonino, additional, Neutel, C. Ineke, additional, Nielsen, Suzanne, additional, Nomura, Motoo, additional, Oliva, Francesco, additional, Olive, M. Foster, additional, Olivoni, Deanna, additional, Ouyang, Qin, additional, Pallesen, Ståle, additional, Palmaro, Aurore, additional, Papazisis, Georgios, additional, Paris, Jason J., additional, Park, Chan-A, additional, Park, Jeong Ha, additional, Pełka Wysiecka, Justyna, additional, Pearson-Dennett, Verity, additional, Phillips, Daniel E., additional, Pinna, Martina, additional, Plener, Paul L., additional, Ramoz, Nicolas, additional, Renshaw, Perry F., additional, Reyes, Beverly A.S., additional, Rivera, Alicia, additional, Robinson, Susan E., additional, Romolo, Francesco S., additional, Roohbakhsh, Ali, additional, Rouini, Mohammadreza, additional, Roussin, Anne, additional, Roussotte, Florence F., additional, Saiz, P.A., additional, Samochowiec, J., additional, Sanchis-Segura, Carla, additional, Santacroce, Rita, additional, Sato-Bigbee, Carmen, additional, Sayin, H. Umit, additional, Searles Quick, Veronica B., additional, Şenormanci, Ömer, additional, Seseña, Emmanuel, additional, Shamsizadeh, Ali, additional, Sheikholeslami, Behjat, additional, Shen, Bin, additional, Shibasaki, Masahiro, additional, Shillcutt, Samuel D., additional, Simola, Nicola, additional, Singh, Rachana, additional, Soraisham, Amuchou Singh, additional, Soto, Enrique, additional, Soyka, Michael, additional, Stepens, Ainars, additional, Sullman, Mark J.M., additional, Sun, Linlin, additional, Suzuki, Tsutomu, additional, Szabo, Attila, additional, Taba, Pille, additional, Tang, Hong Chai, additional, Tang, Tze-Chun, additional, Tao, Yuan-Xiang, additional, ten Velden Hegelstad, Wenche, additional, Thome, Johannes, additional, Thompson, Paul M., additional, Tien, Lu-Tai, additional, Tietz, Elizabeth I., additional, Todd, Gabrielle, additional, Tolcos, Mary, additional, Torkamanian, Meshkat, additional, Tsung, Jieh-Hen, additional, Tufik, Sergio, additional, Ullah, Mafaz, additional, Vaiano, Fabio, additional, Van Bockstaele, Elisabeth J., additional, Vandrey, Ryan, additional, Vazquez-Sanroman, Dolores, additional, Vega, Rosario, additional, Vitali, Mario, additional, Wai, Maria S.M., additional, Wang, Junmei, additional, Wang, Lirong, additional, Wang, Sheng-Chang, additional, Weibell, Melissa A., additional, Weinstein, Aviv, additional, White, Jason M., additional, Wilcox, Robert A., additional, Wilson, Hester, additional, Wouldes, Trecia A., additional, Wydra, Karolina, additional, Xie, Xiang-Qun, additional, Xie, Zhaojun, additional, Xi, Zheng-Xiong, additional, Xu, Wang, additional, Yang, Hai-Yu, additional, Yang, Peng, additional, Yechiam, Eldad, additional, Yew, David T., additional, Yong, Andrew W.S., additional, Zamani, Nasim, additional, Zoellner, Hans, additional, and Zuba, Dariusz, additional

Published
2016
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47. Reward Deficiency Syndrome (RDS) Surprisingly Is Evolutionary and Found Everywhere: Is It “Blowin’ in the Wind”?

Author

Blum, Kenneth, primary, McLaughlin, Thomas, additional, Bowirrat, Abdalla, additional, Modestino, Edward J., additional, Baron, David, additional, Gomez, Luis Llanos, additional, Ceccanti, Mauro, additional, Braverman, Eric R., additional, Thanos, Panayotis K., additional, Cadet, Jean Lud, additional, Elman, Igor, additional, Badgaiyan, Rajendra D., additional, Jalali, Rehan, additional, Green, Richard, additional, Simpatico, Thomas A., additional, Gupta, Ashim, additional, and Gold, Mark S., additional

Published
2022
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48. Early Routine Biomarkers of SARS-CoV-2 Morbidity and Mortality: Outcomes from an Emergency Section

Author

Ceci, Flavio Maria, primary, Fiore, Marco, additional, Gavaruzzi, Francesca, additional, Angeloni, Antonio, additional, Lucarelli, Marco, additional, Scagnolari, Carolina, additional, Bonci, Enea, additional, Gabanella, Francesca, additional, Di Certo, Maria Grazia, additional, Barbato, Christian, additional, Petrella, Carla, additional, Greco, Antonio, additional, Vincentiis, Marco De, additional, Ralli, Massimo, additional, Passananti, Claudio, additional, Poscia, Roberto, additional, Minni, Antonio, additional, Ceccanti, Mauro, additional, Tarani, Luigi, additional, and Ferraguti, Giampiero, additional

Published
2022
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49. Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

Author

Ferraguti, Giampiero, primary, Terracina, Sergio, additional, Petrella, Carla, additional, Greco, Antonio, additional, Minni, Antonio, additional, Lucarelli, Marco, additional, Agostinelli, Enzo, additional, Ralli, Massimo, additional, de Vincentiis, Marco, additional, Raponi, Giammarco, additional, Polimeni, Antonella, additional, Ceccanti, Mauro, additional, Caronti, Brunella, additional, Di Certo, Maria Grazia, additional, Barbato, Christian, additional, Mattia, Alessandro, additional, Tarani, Luigi, additional, and Fiore, Marco, additional

Published
2022
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50. Exploration of Epigenetic State Hyperdopaminergia (Surfeit) and Genetic Trait Hypodopaminergia (Deficit) during Adolescent Brain Development

Author

Blum, Kenneth, primary, Bowirrat, Abdalla, additional, Lewis, Marjorie C.G., additional, Simpatico, Thomas A., additional, Ceccanti, Mauro, additional, Steinberg, Bruce, additional, Modestino, Edward J., additional, Thanos, Panayotis K., additional, Baron, David, additional, McLaughlin, Thomas, additional, Brewer, Raymond, additional, Badgaiyan, Rajendra D., additional, Ponce, Jessica V., additional, Lott, Lisa, additional, and Gold, Mark S., additional

Published
2021
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