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Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic liver alteration whose prevalence is increasing in Western countries. Microalgae and macroalgae have attracted great interest due to the high content in bioactive compounds with beneficial effects on health. The aim of the present study is to assess the potential interest of extracts rich in proteins obtained from the microalgae Chlorella vulgaris and Nannochloropsis gaditana and the macroalga Gracilaria vermiculophylla in the prevention of lipid accumulation in AML-12 hepatocytes. Toxicity was not observed at any of the tested doses. Both microalgae and the macroalga were effective in preventing triglyceride accumulation, with Nannochloropsis gaditana being the most effective one. Although the three algae extracts were able to increase different catabolic pathways involved in triglyceride metabolism, the mechanisms underlying the anti-steatotic effect were different in each algae extract. In conclusion, the present study demonstrates that Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla extracts are able to partially prevent the accumulation of triglycerides induced by palmitic acid in cultured hepatocytes, a model used to mimic the steatosis induced in liver by dietary patterns rich in saturated fat.

Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic liver alteration whose prevalence is increasing in Western countries. Microalgae and macroalgae have attracted great interest due to the high content in bioactive compounds with beneficial effects on health. The aim of the present study is to assess the potential interest of extracts rich in proteins obtained from the microalgae Chlorella vulgaris and Nannochloropsis gaditana and the macroalga Gracilaria vermiculophylla in the prevention of lipid accumulation in AML-12 hepatocytes. Toxicity was not observed at any of the tested doses. Both microalgae and the macroalga were effective in preventing triglyceride accumulation, with Nannochloropsis gaditana being the most effective one. Although the three algae extracts were able to increase different catabolic pathways involved in triglyceride metabolism, the mechanisms underlying the anti-steatotic effect were different in each algae extract. In conclusion, the present study demonstrates that Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla extracts are able to partially prevent the accumulation of triglycerides induced by palmitic acid in cultured hepatocytes, a model used to mimic the steatosis induced in liver by dietary patterns rich in saturated fat.

[ES] El presente trabajo contempla el estudio del estado actual del edificio del Gran Casino ubicado en la ciudad de Vila-real, analizando algunas de sus patologías y aportando propuestas para su intervención basándose en los criterios y técnicas adecuadas y las valoraciones de las mismas. Para todo ello se ha recopilado previamente, información de diferentes fuentes documentales e históricas, compaginándolo con trabajo de campo., [EN] The following project represents the study and investigation of the actual building of Gran Casino , which can be found and in the city of Vila-real. It includes the analysis of some of the buildings pathologies, as well as proposals for its future intervention based on the criteria and adequate techniques, together with their evaluation. In order to achieve all of this, information of different sources, historical and graphical has been gathered, combining it with the possibility of visiting the side whenever was needed.

[ES] El siguiente Trabajo de Fin de Grado de la titulación de arquitectura técnica es una proposición para la intervención y cambio de uso del edificio de la calle Molí nº4, más conocido como “el antiguo Cine Condal” por los vecinos de Vila-real. Está ubicado en Vila-real, Castellón. Se trata de un edificio construido a principios del siglo anterior y está anexo a la parroquia y convento de los Padres Franciscanos. Este edificio, como se explicará en el proyecto, durante el paso de los años, se ha destinado a diversos usos. Aunque el interior se ha conservado prácticamente bien, la fachada principal es la parte más dañada y afectada. Durante varias visitas que se han realizado en estos meses al edificio, se ha podido recoger toda la información necesaria para el desarrollo del proyecto. Para ello se han tomado medidas, realizado croquis, levantamiento de planos, etc. Por eso, en primer lugar, mediante un análisis constructivo y detallado del edificio y de la fachada, se han presentado en el proyecto diversas fichas de patología para la intervención de la misma. Estudiando cada lesión y el tipo de material usado en la época, y seguidamente realizando un análisis de las posibles causas y la propuesta de intervención correspondiente. En segundo lugar, se presenta una propuesta de cambio de uso de la planta baja y una nueva distribución de los espacios de la planta primera, aprovechando mejor el espacio. Para la propuesta del trabajo, toda la información recogida se ha plasmado tanto en explicaciones, como en fichas de patología y en planos., [EN] The following Final Degree Project of the Bachelor’s Degree in Technical Architecture (o Building Engineering, creo que arch tecnica ya no tienes q poner eh… no se) consists of a proposal for the intervention and functional change of a building, which can be found at Nº 4 of Molí Street, in Vila-real, Castellón; best known by its neighbours by the name of ‘the old County Cinema’. The building was constructed in the beginning of the XXth century and it is placed next to the Parish and Convent of the Franciscans Fathers. This building, as it is explained in the project, has been destined to diverse usages along the years. Even though the interior has been preserved quite well, the front façade is the part that has suffered most damages. During the months corresponding to the elaboration of this project, many visits to the site have been made, having permitted to collect all the necessary information needed to elaborate the project. In order to accomplish it, measurements have been taken, site drawings have been made as well as the digital plans of the building. Firstly, throughout a detailed constructive analysis of the building and the façade, several pathology files had to be made, for a posterior and more coherent intervention. This allowed to study very well each of them and the type of material used back then, being able to discover the causes of the damage and choosing the correspondent intervention. Second, the proposal consists of a functional change for the ground floor and a new distribution of spaces on the first floor, making the most out of it. For the overall proposal in this project, all the gathered information relies on the texts, the pathology files and finally, the plans.