1. A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33 weeks.
- Author
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Mubiru JN, Garcia-Forey M, Higgins PB, Hemmat P, Cavazos NE, Dick EJ Jr, Owston MA, Bauer CA, Shade RE, Comuzzie AG, and Rogers J
- Subjects
- Absorptiometry, Photon veterinary, Animals, Blood Glucose analysis, Cholesterol blood, Cholesterol chemistry, Dietary Carbohydrates adverse effects, Dietary Fats adverse effects, Energy Metabolism, Insulin blood, Male, Metabolic Syndrome blood, Metabolic Syndrome etiology, Metabolic Syndrome physiopathology, Models, Animal, Triglycerides blood, Biomarkers blood, Body Composition, Body Weight, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Macaca fascicularis metabolism, Metabolic Syndrome veterinary
- Abstract
Background: The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition., Methods: We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33 weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33 weeks., Results: The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33 weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period., Conclusions: Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome., (© 2011 John Wiley & Sons A/S.)
- Published
- 2011
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