Search

Your search keyword '"Cavallini, Gian Maria"' showing total 343 results
Start Over Author "Cavallini, Gian Maria"
343 results on '"Cavallini, Gian Maria"'

3. Levosimendan and Dobutamin Attenuate LPS-Induced Inflammation in Microglia by Inhibiting the NF-κB Pathway and NLRP3 Inflammasome Activation via Nrf2/HO-1 Signalling.

Author

Mannino, Federica, Urzì Brancati, Valentina, Lauro, Rita, Pirrotta, Igor, Rottura, Michelangelo, Irrera, Natasha, Cavallini, Gian Maria, Pallio, Giovanni, Gitto, Eloisa, and Manti, Sara

Subjects
LEVOSIMENDAN, DOBUTAMINE, NLRP3 protein, INFLAMMASOMES, HYPOVOLEMIC anemia, MICROGLIA, CARDIOGENIC shock
Abstract

Hypovolemic shock is a circulatory failure, due to a loss in the effective circulating blood volume, that causes tissue hypoperfusion and hypoxia. This condition stimulates reactive oxygen species (ROS) and pro-inflammatory cytokine production in different organs and also in the central nervous system (CNS). Levosimendan, a cardioprotective inodilator, and dobutamine, a β1-adrenergic agonist, are commonly used for the treatment of hypovolemic shock, thanks to their anti-inflammatory and antioxidant effects. For this reason, we aimed at investigating levosimendan and dobutamine's neuroprotective effects in an "in vitro" model of lipopolysaccharide (LPS)-induced neuroinflammation. Human microglial cells (HMC3) were challenged with LPS (0.1 µg/mL) to induce an inflammatory phenotype and then treated with levosimendan (10 µM) or dobutamine (50 µM) for 24 h. Levosimendan and dobutamine significantly reduced the ROS levels and markedly increased Nrf2 and HO-1 protein expression in LPS-challenged cells. Levosimendan and dobutamine also decreased p-NF-κB expression and turned off the NLRP3 inflammasome together with its downstream signals, caspase-1 and IL-1β. Moreover, a reduction in TNF-α and IL-6 expression and an increase in IL-10 levels in LPS-stimulated HMC3 cells was observed following treatment. In conclusion, levosimendan and dobutamine attenuated LPS-induced neuroinflammation through NF-κB pathway inhibition and NLRP3 inflammasome activation via Nrf2/HO-1 signalling, suggesting that these drugs could represent a promising therapeutic approach for the treatment of neuroinflammation consequent to hypovolemic shock. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Reply

Author

Date, Purva, Forlini, Matteo, Ferrari, Tommaso Micelli, DʼEliseo, Domenico, and Cavallini, Gian Maria

Published
2019
Full Text
View/download PDF

14. Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis

Author

Gozzi, Fabrizio, primary, Belloni, Lucia, additional, Aldigeri, Raffaella, additional, Gentile, Pietro, additional, Mastrofilippo, Valentina, additional, De Simone, Luca, additional, Bolletta, Elena, additional, Alessandrello, Federica, additional, Bonacini, Martina, additional, Croci, Stefania, additional, Zerbini, Alessandro, additional, Cavallini, Gian Maria, additional, Salvarani, Carlo, additional, and Cimino, Luca, additional

Published
2022
Full Text
View/download PDF

29. Long-Term Evaluation of Capsulotomy Shape and Posterior Capsule Opacification after Low-Energy Bimanual Femtosecond Laser-Assisted Cataract Surgery

Author

Verdina, Tommaso, Peppoloni, Chiara, Barbieri, Lucrezia, Carbotti, Maria Rosaria, Battaglia, Bruno, Mastropasqua, Rodolfo, and Cavallini, Gian Maria

Subjects
Ophthalmology, Article Subject, RE1-994, eye diseases, Research Article
Abstract

Purpose To evaluate capsulotomy shape and posterior capsule opacification (PCO) during an 18-month follow-up for bimanual femtosecond laser-assisted cataract surgery (FLACS). Methods 74 eyes operated by a well-trained surgeon with bimanual FLACS technique using low-energy LDV Z8 (Ziemer Ophthalmic Systems AG, Port, Switzerland) were included in the study. The follow-up period was 18 ± 2 months. Another 91 eyes, which underwent standard bimanual microincision cataract surgery (B-MICS), served as a control group. In all cases, a BunnyLens AF (Hanita Lenses, Israel) intraocular lens was implanted in the bag. A digital image of the capsule with slit-lamp retroillumination was performed in all patients at 18 months of follow-up. Image analysis software (ImageJ) was used to evaluate the shape of the capsulotomy in terms of diameter, area, and circularity. PCO score was evaluated using EPCO 2000 software. Best corrected visual acuity (BCVA) and endothelial cell count (ECC) were evaluated before and after surgery at 1 and 18 ± 2 months. Results At 18 months, mean capsulotomy diameter was 5.34 ± 0.21 mm while capsulorhexis was 5.87 ± 0.37 mm (p < 0.001) and the deviation area from baseline was 1.13 ± 1.76 mm2 in FLACS and 2.67 ± 1.69 mm2 in B-MICS (p < 0.001). Capsulotomy circularity was 0.94 ± 0.04 while capsulorhexis was 0.83 ± 0.07 (p < 0.001). EPCO score was 0.050 ± 0.081 in the FLACS group and 0.122 ± 0.239 in the B-MICS group (p=0.03). The mean BCVA improvement was significant in both groups, without a significant difference at 18 months. We noticed a statistically significant difference in endothelial cell loss at 18 months (FLACS 12.4% and B-MICS 18.1%; p=0.017). Conclusions Bimanual FLACS is a safe and effective technique, as determined in a long-term follow-up. Capsulotomy shape presented higher stability and circularity in the FLACS group over the 18-month observation period. FLACS resulted in lower PCO scores and endothelial cell loss at 18 months in comparison to B-MICS standard technique.

Published
2020

30. The Role of Subthreshold Micropulse Yellow Laser as an Alternative Option for the Treatment of Refractory Postoperative Cystoid Macular Edema

Author

Verdina, Tommaso, D'Aloisio, Rossella, Lazzerini, Andrea, Ferrari, Cecilia, Valerio, Edoardo, Mastropasqua, Rodolfo, and Cavallini, Gian Maria

Subjects
post-surgical cystoid macular edema, genetic structures, lcsh:R, micropulse yellow laser, lcsh:Medicine, sense organs, cataract surgery, refractory macular edema, Article, eye diseases
Abstract

Background: To evaluate the efficacy and the safety of subthreshold micropulse yellow laser (SMYL) in the treatment of chronic postoperative cystoid macular edema (PCME), which is refractory to standard therapies. Methods: A retrospective chart review of ten eyes of ten patients affected by refractory PCME who underwent SMYL was performed. Five PCME cases were subsequent to uncomplicated cataract surgery (CS), two cases to complicated CS (CCS) with posterior capsule rupture and three cases occurred after retinal detachment surgery (RD). All conditions were refractory to conventional treatments prior to SMYL interventions for at least 4 months, including nonsteroidal anti-inflammatory eyedrops, topical steroids, oral indomethacin, sub-Tenon’s triamcinolone injections and Dexamethasone intravitreal implants. All patients underwent one or more treatments with 577 nm SMYL photo-stimulation, with 7 × 7 grids with confluent spots and a 5% duty cycle covering the whole edematous retina, including the foveal center. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were obtained using OCT, and evaluated before and after the treatment at 1, 2, 3 and 6-month follow-ups. Results: A complete subfoveal macular edema resolution was observed in all of the eyes, with statistically significant improvements in terms of BCVA and CMT in all of the follow-up timelines (at 6 months, p = 0.002 and p = 0.005, respectively). The mean number of laser treatments was 1.3. At the final follow-up, a complete subfoveal edema reabsorption was observed in all patients with visual acuity improvement. No complications were observed in any case. Conclusions: SMYL seems to be a safe and effective treatment for the long-term resolution of refractory PCME and may be a useful alternative to expensive and invasive therapeutic options.

Published
2020

34. Limited Vitrectomy versus Complete Vitrectomy for Epiretinal Membranes: A Comparative Multicenter Trial

Author

Forlini, Matteo, primary, Date, Purva, additional, D’Eliseo, Domenico, additional, Rossini, Paolo, additional, Bratu, Adriana, additional, Volinia, Andrea, additional, Neri, Giovanni, additional, Verdina, Tommaso, additional, Carbotti, Maria Rosaria, additional, Cavallini, Gian Maria, additional, Sborgia, Luigi, additional, Galeone, Alessandra, additional, Imburgia, Aurelio, additional, Mularoni, Alessandro, additional, and Meduri, Alessandro, additional

Published
2020
Full Text
View/download PDF

35. CONTRIBUTORS

Author

Abbott, Richard L., primary, Afshari, Natalie A., additional, Agrawal, Jaya, additional, Agrawal, Shishir, additional, Agrawal, Trilok P., additional, Akduman, Levent, additional, Akpek, Esen K., additional, Al-Sayyed, Amal, additional, Albini, Thomas A., additional, Alcorn, Deborah M., additional, Alwitry, Amar, additional, Amzel, Anouk, additional, Anderson, Nicole J., additional, Ansari, Ejaz A., additional, Antoszyk, Andrew, additional, Antoszyk, James H., additional, Aquavella, James V., additional, Arain, Sumaira A., additional, Arévalo, J. Fernando, additional, Arunagiri, Guruswami, additional, Arzabe, Carlos W., additional, Atchaneeyasakul, La-ongsri, additional, Atilla, Huban, additional, Aykan, Ümit, additional, Ayres, Brandon D., additional, Barbón, Juan J., additional, Bailey, Kristi, additional, Baloh, Frank G., additional, Barequet, Irina S., additional, Barkhuizen, André, additional, Bearn, Michael A., additional, Belfort, Rubens, additional, Bellows, A. Robert, additional, Berrocal, Audina M., additional, Bettink-Remeijer, Marijke Wefers, additional, Bhandari, Anuja, additional, Bhatti, M. Tariq, additional, Blumenkranz, Mark S., additional, Boboridis, Kostas G., additional, Bolling, James P., additional, Boniuk, Vivien, additional, Botelho, Paul Jorge, additional, Brazis, Paul W., additional, Bremner, Fion D., additional, Buckley, Edward G., additional, Bullock, John D., additional, Bushley, David Matthew, additional, Caldeira, Jorge Alberto F., additional, Carricajo, Anne, additional, Cavallini, Gian Maria, additional, Chan, Matilda Frances, additional, Chandler, Damon B., additional, Channa, H., additional, Char, Devron H., additional, Charles, Steve, additional, Chen, Teresa C., additional, Ching, Steven S.T., additional, Chiquet, Christophe, additional, Hyunchul, Phillip, additional, Chou, Timothy Y., additional, Christiansen, Stephen P., additional, Chung, Kelly D., additional, Cioffi, George A., additional, Clarke, Michael P., additional, Coats, David K., additional, Cohen, Elisabeth J., additional, Conway, R. Max, additional, Creuzot-Garcher, Catherine, additional, Cunningham, Emmett T., additional, Curtis, Theodore H., additional, Dailey, Roger A., additional, Davis, Richard M., additional, Cock, Romain De, additional, de Faber, Jan-Tjeerd H.N., additional, de la Mano, Daniel, additional, Dekkers, Nick W.H.M., additional, Monte, Monte Anthony Del, additional, Rocca, David A. Della, additional, Rocca, Robert C. Della, additional, Dhaliwal, Deepinder K., additional, Do, Diana V., additional, Dolman, Peter J., additional, Donahue, Sean P., additional, Donnenfeld, Eric D., additional, Duguid, Graham, additional, Duker, Jay S., additional, Dunn, James P., additional, Dunn, Steven P., additional, Duong, Hon-Vu Q., additional, Egan, Robert A., additional, Eichler, Michael D., additional, El-Dairi, Mays, additional, Ellis, Forrest J., additional, Emerson, Geoffrey, additional, Emerson, M. Vaughn, additional, Enyedi, Laura B., additional, Evans, Teodoro, additional, Falardeau, Julie, additional, Faris, Bishara M., additional, Feitl, Marianne E., additional, Felton, Warren L., additional, Feman, Stephen S., additional, ffytche, Timothy J, additional, Flaxel, Christina J., additional, Foroozan, Rod, additional, Foster, Allen, additional, Fraunfelder, Frederick T., additional, Fraunfelder, Frederick W., additional, Freeman, H. Mackenzie, additional, Friedlaender, Mitchell H., additional, Frohman, Larry P., additional, Fung, Wayne E., additional, Gain, Philippe, additional, Gaitan, Jaime R., additional, Gancher, Stephen, additional, Gard, Tim, additional, Gattey, Devin M., additional, Gehlbach, Peter L., additional, Ghajarnia, Mehdi, additional, Ghanem, Vinícius Coral, additional, Ghosh, Amit Kumar, additional, Ghosh, Chandak, additional, Giegengack, Matthew, additional, Gladstone, Geoffrey, additional, Gold, Daniel H., additional, Golub, Richard L., additional, Gombos, Dan S., additional, Gombos, George M., additional, Good, William V., additional, Goodman, Shawn, additional, Gottsch, John D., additional, Goverdhan, Srinivas, additional, Grimson, Baird S., additional, Güemes, Adolfo, additional, Guerra, Roberto, additional, Haller, Julia A., additional, Hammersmith, Kristin M., additional, Handelman, Irvin L., additional, Hargrove, Roderick N., additional, Harney, Michael S., additional, Harper, Richard A., additional, Hatt, Sarah R., additional, Hawkins, Barbara S., additional, Hayreh, Sohan S., additional, Heiligenhaus, Arnd, additional, Heinz, Carsten, additional, Herndon, Leon W., additional, Hickman, Simon J., additional, Hirano, Koji, additional, Holland, Edward J., additional, Holland, Gary N., additional, Holz, Eric R., additional, Hommura, Sachiko, additional, Horn, Jeffrey D., additional, Hornick, Richard B., additional, Hoskins, H. Dunbar, additional, Hung, James W., additional, Hunter, Brian A., additional, Hunter, Krista A., additional, Hunyor, Alex P., additional, Hurwitz, Brian, additional, Hwang, Thomas S., additional, Hyndiuk, Robert A., additional, Ilhan-Sarac, Ozge, additional, Ing, Edsel, additional, Ino-ue, Masanori, additional, Isada, Carlos M., additional, Iturriaga, Saylin, additional, Iuorno, Joseph D., additional, Iwach, Andrew G., additional, Iyer, Mohan N., additional, Izquierdo, Natalio J., additional, Jampol, Lee M., additional, Johnston, Suzanne, additional, Kadayifçilar, Sibel, additional, Kaden, Ian H., additional, Kaimbo, Dieudonne Kaimbo Wa, additional, Kapur, Rashmis, additional, Kastl, Peter R., additional, Katsavounidou, Garyfallia, additional, Kazerouni, Ayat, additional, Kazim, Michael, additional, Kedhar, Sanjay R., additional, Keech, Ronald V., additional, Kersten, Robert C., additional, Keys, Marshall P., additional, Khanna, Sangeeta, additional, Khaw, Peng Tee, additional, Kinyoun, James L., additional, Kirwan, Caitriona, additional, Kivelä, Tero, additional, Klein, Michael L., additional, Klotz, Stephen A., additional, Ko, John, additional, Kowalski, Regis P., additional, Krachmer, Jay H., additional, Krupin, Theodore, additional, Kuhn, Ferenc, additional, Kulkarni, Abhaya Vivek, additional, Kwun, Robert C., additional, Laibson, Peter R., additional, Lakhanpal, Rohit R., additional, Lam, Byron L., additional, Lamer, Laurent, additional, Lawlor, David P., additional, Lawton, Andrew W., additional, Leahey, Alan B., additional, LeBoyer, Russell, additional, Lee, Andrew G., additional, Lee, Wen-Hsiang, additional, Lee, William Barry, additional, Lehman, Sharon S., additional, Leibowitz, Howard M., additional, Leong, James, additional, Levin, Alex V., additional, Levin, Leonard A., additional, Levine, Mark R., additional, Levy, Norman S., additional, Liesegang, Thomas J., additional, Lim, Lyndell L., additional, Lin, Linda H., additional, Lisman, Richard D., additional, Litoff, David, additional, Liu, James C., additional, Loft, Evan, additional, Lubritz, Ronald R., additional, Mabey, David C.W., additional, Mackie, Ian A., additional, Maguluri, Srilakshmi, additional, Maliki, M., additional, Mamalis, Nick, additional, Mannis, Mark J., additional, Mansberger, Steven L., additional, Mansour, Ahmad M., additional, Marcon, Alexandre S., additional, Marcon, Italo M., additional, Marsh, Peter B., additional, Mather, Rookaya, additional, Mathers, William D., additional, Saari, K. Matti, additional, Mawn, Louise A., additional, McAllum, Penny J., additional, McCallum, Rex M., additional, McCluskey, Peter, additional, McCormick, Gregory J., additional, McCormick, Steven A., additional, McCulley, James P., additional, McHenry, John G., additional, McNab, Alan A., additional, Mee, Jared J., additional, Meier, Douglas L., additional, Meisler, David M., additional, Merin, Saul C., additional, Meyer, Dale R., additional, Meyer, Roger F., additional, Michels, Kevin S., additional, Milman, Tatyana, additional, Mintz, Roni, additional, Morel, Chantal F, additional, Morris, William R., additional, Moster, Mark L., additional, Mourani, John, additional, Muccioli, Cristina, additional, Mudumbai, Raghu C., additional, Murillo-Lopez, Fernando H., additional, Myint, Shoib, additional, Nagra, Parveen K, additional, Naoumi, A, additional, Nassif, John, additional, Nee, Michelle T., additional, Netto, Marcelo V., additional, Ng, John D., additional, Nguyen, Hau T., additional, Nguyen, Quan Dong, additional, O'Day, Denis M., additional, O'Day, A. Justin, additional, O'Halloran, Henry S., additional, O'Keefe, Michael, additional, Okamoto, Fumiki, additional, Olson, Richard J., additional, Orcutt, James C., additional, Dundar, Sema Oruc, additional, Osbourne, Aaron, additional, Palazzi, Maristela Amaral, additional, Palmer, Earl A., additional, Papadopoulos, Maria, additional, Parnell, Jeffrey R., additional, Parsa, Cameron F., additional, Patel, Sanjay V., additional, Patterson, Emily, additional, Pendergast, Scott D., additional, Perry, Henry D., additional, Peters, Keith Roberson, additional, Po, Stephanie M., additional, Pokroy, Russell, additional, Putterman, Allen Michael, additional, Queiro, Rubén, additional, Rafiei, Nastaran, additional, Rahmani, Bahram, additional, Rapuano, Christopher J, additional, Rasheed, Karim, additional, Rathinam, S.R., additional, Raymond, Lawrence A., additional, Read, Russell W., additional, Lafayette, August, additional, Recchia, Franco M., additional, Reidy, James J., additional, Reynolds, Adam C., additional, Rich, Larry F., additional, Ritch, Robert, additional, Robb, Richard M., additional, Robert, Pierre-Yves, additional, Robertson, Joseph E., additional, Roh, Shiyoung, additional, Romanet, Jean-Paul, additional, Rootman, Jack, additional, Roque, Barbara L., additional, Roque, Manolette R., additional, Rosenbaum, Arthur L., additional, Rosenbaum, James Todd, additional, Roy, F. Hampton, additional, Rundle, Paul A., additional, Sadun, Alfredo A., additional, Saffra, Norman A., additional, Salim, Sarwat, additional, Samples, John R., additional, Santiago, Alvina Pauline D, additional, Saperstein, David A., additional, Saunders, Richard A., additional, Savage, James A., additional, Scheufele, Tina A., additional, Schiedler, Vivian, additional, Schlesinger, Thomas K., additional, Schlossman, Abraham, additional, Schwartz, Lee K., additional, Scott, Ingrid U., additional, Scruggs, Jennifer, additional, Segal, Ernesto I., additional, Shalaby, Ismail A., additional, Sheikh, Aziz, additional, Sheppard, John D., additional, Sherman, Mark D., additional, Shields, Carol L., additional, Shields, Jerry A., additional, Singh, Amarpreet, additional, Singh, Christopher N., additional, Singman, Eric L., additional, Siracuse-Lee, Donna, additional, Smalley, Aaron D., additional, Smith, Patricia W., additional, Solomon, Anthony W., additional, Souhail, Hassane, additional, Spitzberg, Daniel H., additional, Spoor, Thomas C., additional, Stamper, Robert L., additional, Stark, Walter J., additional, Steele, Eric A., additional, Steinemann, Thomas L., additional, Stout, Ann U., additional, Stout, J. Timothy, additional, Stulting, R. Doyle, additional, Sugar, Alan, additional, Sugar, Joel, additional, Suh, Donny W., additional, Suhler, Eric B., additional, Sullivan, John H., additional, Sutphin, John Everett, additional, Swan, Kenneth C., additional, Tabbara, Khalid F., additional, Tamber, Mandeep S., additional, Tanna, Angelo P., additional, Tatlipinar, Sinan, additional, Tayani, Ramin, additional, Teichmann, Klaus D., additional, Terry, Mark A., additional, Tham, Clement Chee Yung, additional, Therzaz, A., additional, Thuret, Gilles, additional, Tinley, Christopher Graham, additional, Tongue, Andrea C., additional, Torres, Rodrigo J., additional, Tower, Robert N., additional, Traboulsi, Elias I, additional, Trikha, Rupan, additional, Tripathi, Brenda J., additional, Tripathi, Ramesh C., additional, Tugal-Tutkun, Ilknur, additional, Tung, Irene, additional, Evendingen, Judith A. M. Van, additional, Vaudaux, Jean D., additional, Wairagkar, Niteen S, additional, Walrath, Joseph D., additional, Walsh, Rory McConn, additional, Walton, David S., additional, Warwar, Ronald E., additional, Watson, Peter G., additional, Weiter, John J., additional, Weleber, Richard G., additional, Wertz, Fleming D., additional, Westra, Igor, additional, Wheeler, David T., additional, Wilkinson, Charles P., additional, Wilson, David J., additional, Wilson, M. Edward, additional, Wilson, Matthew W., additional, Wilson, Steven E, additional, Wobig, John L., additional, Wood, Terry D., additional, Wu, Lihteh, additional, Yalcinbayir, Ozgur, additional, Ying, Howard Shann-Cherng, additional, Youssef, Peter N., additional, and Zaidman, Gerald W., additional

Published
2008
Full Text
View/download PDF

49. Multimodal analysis of the Preferred Retinal Location and the Transition Zone with macular atrophy in Patients with Stargardt Disease

Author

Verdina, Tommaso, Greenstein, Vivienne C., Sodi, Andrea, Tsang, Stephen H., Burke, Tomas R., Passerini, Ilaria, Allikmets, Rando, Virgili, Gianni, Cavallini, Gian Maria, and Rizzo, Stanislao

Subjects
Adult, Male, Fundus Oculi, Visual Acuity, Reproducibility of Results, Retinal Pigment Epithelium, Middle Aged, Multimodal Imaging, Article, Ophthalmoscopy, Macular Degeneration, Young Adult, Humans, Stargardt Disease, Female, Macula Lutea, Fluorescein Angiography, Visual Fields, Tomography, Optical Coherence, Aged, Retrospective Studies
Abstract

The purpose of our study was to investigate morpho-functional features of the preferred retinal location (PRL) and the transition zone (TZ) in a series of patients with recessive Stargardt disease (STGD1).Fifty-two STGD1 patients with at least one ABCA4 mutation, atrophy of the central macula (MA) and an eccentric PRL were recruited for the study. Microperimetry, fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT) were performed. The location and stability of the PRL along with the associated FAF pattern and visual sensitivities were determined and compared to the underlying retinal structure.The mean visual sensitivity of the PRLs for the 52 eyes was 10.76 +/- 3.70 dB. For the majority of eyes, PRLs were associated with intact ellipsoid zone (EZ) bands and qualitatively normal FAF patterns. In 17 eyes (32.7%) the eccentric PRL was located at the edge of the MA. In 35 eyes (67.3%) it was located at varying distances from the border of the MA with a TZ between the PRL and the MA. The TZ was associated with decreased sensitivity values (5.92 +/- 4.69 dB) compared to PRLs (p0.05), with absence/disruption of the EZ band and abnormal FAF patterns (hyper or hypo-autofluorescence).In STGD1 eccentric PRLs are located away from the border of MA and associated with intact EZ bands and normal FAF. The TZ is characterized by structural and functional abnormalities. The results of multimodal imaging of the PRL and TZ suggest a possible sequence of retinal and functional changes with disease progression that may help in the planning of future therapies; RPE dysfunction appears to be the primary event leading to photoreceptor degeneration and then to RPE loss.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results