Search

Your search keyword '"Cavaleri, Daniele"' showing total 110 results
Start Over Author "Cavaleri, Daniele"
110 results on '"Cavaleri, Daniele"'

5. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Aguglia, Eugenio, Aguglia, Andrea, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Barbato, Angelo, Barbui, Corrado, Bartoli, Francesco, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callegari, Camilla, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandro, Carbone, Elvira, Carosielli, Doriana, Carrà, Giuseppe, Cartabia, Massimo, Caselli, Ivano, Cavaleri, Daniele, Cavallotti, Simone, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, D'Agostino, Armando, D'Avanzo, Barbara, De Fazio, Pasquale, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Gari, Matteo, Gastaldon, Chiara, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Ielmini, Marta, Ingrosso, Gianmarco, Isella, Celeste, Lax, Annamaria, Mammarella, Silvia, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Monti, Igor, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Ostuzzi, Giovanni, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Rodolico, Alessandro, Romito, Samantha, Ronchi, Barbara, Roncone, Rita, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sterzi, Enrico, Sturiale, Serena, Tambelli, Antonio, Tettamanti, Mauro, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, Zerbinati, Luigi, Canozzi, Andrea, Carbone, Elvira Anna, Caruso, Rosangela, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, de Filippis, Renato, Martinotti, Giovanni, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, and Amaddeo, Francesco

Published
2024
Full Text
View/download PDF

14. Prioritising the Mental Health of Psychiatric Trainees across Europe

Author

Cavaleri, D, Longo, G, King, J, Kozina, L, Ryland, H, Santos Martins, F, Sprengers, J, Stirland, L, Seker, A, Cavaleri, Daniele, Longo, Giulio, King, Jacob D., Kozina, Lea, Ryland, Howard, Santos Martins, Filipa, Sprengers, Jan J., Stirland, Lucy, Seker, Asilay, Cavaleri, D, Longo, G, King, J, Kozina, L, Ryland, H, Santos Martins, F, Sprengers, J, Stirland, L, Seker, A, Cavaleri, Daniele, Longo, Giulio, King, Jacob D., Kozina, Lea, Ryland, Howard, Santos Martins, Filipa, Sprengers, Jan J., Stirland, Lucy, and Seker, Asilay

Abstract

This first special issue of the International Journal of Psychiatric Trainees (previously named European Journal of Psychiatric Trainees) features four articles based on posters presented at the 31st Forum of the European Federation of Psychiatric Trainees in Zurich. Focusing on mental health challenges faced by psychiatric trainees across Europe – including key themes such as burnout, depression, and the impact of patient suicide – this special issue highlights the need for systematic support programs, improved awareness and utilisation of mental health resources, and structural changes in medical education. By considering these matters, the Journal supports discussion and action towards improving the mental health of psychiatric trainees worldwide.

Published
2024

15. The impact of Patient Suicide on Psychiatric Trainees and Early Career Psychiatrists: a qualitative analysis of feelings and unmet needs from an Italian survey

Author

Longo, G, Cavaleri, D, Di Vincenzo, M, Null, N, Longo, Giulio, Cavaleri, Daniele, Di Vincenzo, Matteo, null, null, Longo, G, Cavaleri, D, Di Vincenzo, M, Null, N, Longo, Giulio, Cavaleri, Daniele, Di Vincenzo, Matteo, and null, null

Abstract

The experience of patient suicide (PS) represents a challenging event that most psychiatrists may deal with during their careers. We conducted a qualitative study to evaluate the emotional impact and reactions to PS, in a small sample of psychiatric trainees and early career psychiatrists (n=15) in one university hospital in Italy. Psychiatric trainees and early career psychiatrists working at the Clinical Psychiatry Unit of Polytechnic University of Marche (Ancona, Italy) were surveyed to assess emotional impact of PS, influence on future work, perceived support, and how the PS experience should be managed. An online survey was conducted, and a qualitative approach (thematic analysis) was used to analyse the data. Fifteen professionals completed the survey. Sadness (47%) and shock (33%) were the most reported emotions, along with feelings of guilt, impotence and inadequacy, disappointment, frustration, and anger. PS seemed to have a strong influence on clinical activity, increasing attention towards the patient and commitment, although the impression of being of limited help to the patient was commonly reported. Albeit valuing the opportunity to share their emotional experience with peers, the respondents highlighted the lack of professional support and the relevant need to implement discussion and interventions to deal with PS. Overall, our findings support the importance of addressing the strong emotional effect of PS on psychiatric trainees and early career psychiatrists as well as the necessity for more structured support strategies in the aftermath of PS. Larger investigations on this topic are warranted.

Published
2024

16. Exploring depression in people with schizophrenia spectrum disorders: A cross-sectional analysis of the clinical relationship with Positive and Negative Syndrome Scale dimensions

Author

Bartoli, F, Calabrese, A, Moretti, F, Castiglioni, M, Prestifilippo, L, De Pietra, A, Gazzola, M, Camera, P, Crocamo, C, Carrà, G, Bachi, B, Barbieri, F, Bartoccetti, A, Bassetti, C, Bernasconi, G, Bommartini, C, Bona, P, Boniello, F, Callovini, T, Canestro, A, Capogrosso, C, Cavaleri, D, Cioni, R, Colangelo, F, Di Lella, M, Gianfelice, L, Guzzi, P, Lauria, G, Limonta, S, Lucini Paioni, S, Mauro, S, Morello, P, Morreale, M, Nasti, C, Palpella, D, Piacenti, S, Re, M, Villa, O, Bartoli, Francesco, Calabrese, Angela, Moretti, Federico, Castiglioni, Marta, Prestifilippo, Luca, De Pietra, Aldo, Gazzola, Marco, Camera, Paolo, Crocamo, Cristina, Carrà, Giuseppe, Bachi, Bianca, Barbieri, Filippo Fabio, Bartoccetti, Alessandra, Bassetti, Carlo, Bernasconi, Gianna, Bommartini, Carlo, Bona, Paolo, Boniello, Federica, Callovini, Tommaso, Canestro, Aurelia, Capogrosso, Chiara Alessandra, Cavaleri, Daniele, Cioni, Riccardo Matteo, Colangelo, Francesca, Di Lella, Maria Elisa, Gianfelice, Letizia, Guzzi, Pierluca, Lauria, Giada, Limonta, Serena, Lucini Paioni, Susanna, Mauro, Stefano, Morello, Pietro, Morreale, Marco, Nasti, Christian, Palpella, Dario, Piacenti, Susanna, Re, Martina, Villa, Oliviero., Bartoli, F, Calabrese, A, Moretti, F, Castiglioni, M, Prestifilippo, L, De Pietra, A, Gazzola, M, Camera, P, Crocamo, C, Carrà, G, Bachi, B, Barbieri, F, Bartoccetti, A, Bassetti, C, Bernasconi, G, Bommartini, C, Bona, P, Boniello, F, Callovini, T, Canestro, A, Capogrosso, C, Cavaleri, D, Cioni, R, Colangelo, F, Di Lella, M, Gianfelice, L, Guzzi, P, Lauria, G, Limonta, S, Lucini Paioni, S, Mauro, S, Morello, P, Morreale, M, Nasti, C, Palpella, D, Piacenti, S, Re, M, Villa, O, Bartoli, Francesco, Calabrese, Angela, Moretti, Federico, Castiglioni, Marta, Prestifilippo, Luca, De Pietra, Aldo, Gazzola, Marco, Camera, Paolo, Crocamo, Cristina, Carrà, Giuseppe, Bachi, Bianca, Barbieri, Filippo Fabio, Bartoccetti, Alessandra, Bassetti, Carlo, Bernasconi, Gianna, Bommartini, Carlo, Bona, Paolo, Boniello, Federica, Callovini, Tommaso, Canestro, Aurelia, Capogrosso, Chiara Alessandra, Cavaleri, Daniele, Cioni, Riccardo Matteo, Colangelo, Francesca, Di Lella, Maria Elisa, Gianfelice, Letizia, Guzzi, Pierluca, Lauria, Giada, Limonta, Serena, Lucini Paioni, Susanna, Mauro, Stefano, Morello, Pietro, Morreale, Marco, Nasti, Christian, Palpella, Dario, Piacenti, Susanna, Re, Martina, and Villa, Oliviero.

Abstract

OBJECTIVE: Evidence on the relationship between depression and clinical dimensions of schizophrenia remains limited. This cross-sectional study investigated the association between depression and Positive and Negative Syndrome Scale (PANSS) dimensions in people with schizophrenia spectrum disorders. METHODS: Trained assessors administered the PANSS to measure symptoms of schizophrenia and the Calgary Depression Scale for Schizophrenia to measure depression. The association of depression with overall PANSS score and related dimensions was investigated in multiple logistic regression analyses. RESULTS: We included 231 inpatients with schizophrenia spectrum disorders (mean age: 42.4 (SD: 12.9) years; men: 58.9%; mean overall PANSS score: 82.5 (SD: 20.1); drug-free or naïve: 39.3%), including 78 (33.8%) with clinically significant depressive symptoms. Depression was associated with higher overall (regression coefficient, SE: 0.029, 0.008; p < 0.001) and general psychopathology (regression coefficient, SE: 0.118, 0.023; p < 0.001) PANSS scores. We found an inverse relationship between depression and positive symptoms (regression coefficient, SE: -0.088, 0.028; p = 0.002). No association between depression and negative symptoms was found. CONCLUSION: Despite some limitations, our study shows that people affected by schizophrenia spectrum disorders with depression are likely to show more overall and general psychopathology symptoms but lower positive symptoms. Additional studies are needed to explore the generalizability of our findings.

Published
2024

17. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, Zerbinati, Luigi, Ostuzzi, G, Gastaldon, C, Tettamanti, M, Cartabia, M, Monti, I, Aguglia, A, Aguglia, E, Bartoli, F, Callegari, C, Canozzi, A, Carbone, E, Carrà, G, Caruso, R, Cavallotti, S, Chiappini, S, Colasante, F, Compri, B, D'Agostino, A, De Fazio, P, de Filippis, R, Gari, M, Ielmini, M, Ingrosso, G, Mammarella, S, Martinotti, G, Rodolico, A, Roncone, R, Sterzi, E, Tarsitani, L, Tiberto, E, Todini, L, Amaddeo, F, D'Avanzo, B, Barbato, A, Barbui, C, Alessi, M, Avincola, G, Bachi, B, Bernasconi, G, Birgillito, A, Bisso, E, Bonora, S, Calabrese, A, Callovini, T, Canestro, A, Canonico, S, Capogrosso, C, Carosielli, D, Caselli, I, Cavaleri, D, Cavallotto, C, Cesca, M, Chiarenza, C, Cioni, R, Coloccini, S, Cruciata, M, Cumerlato, C, De Filippis, R, De Palma, M, Del Vecchio, S, Della Rocca, B, Di Natale, C, D'Onofrio, E, Espa, I, Fior, G, Gancitano, M, Giordano, B, Giusti, L, Grassi, L, Guzzi, P, Isella, C, Lax, A, Marano, L, Marconi, F, Marella, M, Metelli, A, Michencig, G, Miuli, A, Moncada, A, Morello, P, Moretti, F, Morreale, M, Mosca, A, Nasti, C, Nosé, M, Ogheri, F, Oresti, M, Ornaghi, A, Palpella, D, Pancheri, C, Papola, D, Passeri, S, Pettorusso, M, Piacenti, S, Pinucci, I, Pugliese, V, Purgato, M, Rania, M, Robbi, F, Romito, S, Ronchi, B, Roselli, V, Segura-Garcia, C, Signorelli, M, Simonelli, G, Sociali, A, Sturiale, S, Tambelli, A, Todesco, B, Trabucco, A, Turrini, G, Villa, V, Wiedenmann, F, Zambuto, L, Zanini, E, Zannini, C, Zerbinati, L, Ostuzzi, Giovanni, Gastaldon, Chiara, Tettamanti, Mauro, Cartabia, Massimo, Monti, Igor, Aguglia, Andrea, Aguglia, Eugenio, Bartoli, Francesco, Callegari, Camilla, Canozzi, Andrea, Carbone, Elvira Anna, Carrà, Giuseppe, Caruso, Rosangela, Cavallotti, Simone, Chiappini, Stefania, Colasante, Fabrizio, Compri, Beatrice, D'Agostino, Armando, De Fazio, Pasquale, de Filippis, Renato, Gari, Matteo, Ielmini, Marta, Ingrosso, Gianmarco, Mammarella, Silvia, Martinotti, Giovanni, Rodolico, Alessandro, Roncone, Rita, Sterzi, Enrico, Tarsitani, Lorenzo, Tiberto, Elisa, Todini, Liliana, Amaddeo, Francesco, D'Avanzo, Barbara, Barbato, Angelo, Barbui, Corrado, Alessi, Maria Chiara, Avincola, Gabriele, Bachi, Bianca, Bernasconi, Gianna, Birgillito, Andrea, Bisso, Emanuele, Bonora, Stefano, Calabrese, Angela, Callovini, Tommaso, Canestro, Aurelia, Canonico, Salvo, Capogrosso, Chiara Alessandra, Carbone, Elvira, Carosielli, Doriana, Caselli, Ivano, Cavaleri, Daniele, Cavallotto, Clara, Cesca, Marco, Chiarenza, Cecilia, Cioni, Riccardo Matteo, Coloccini, Sara, Cruciata, Marco, Cumerlato, Claudia, De Filippis, Renato, De Palma, Manuela, Del Vecchio, Sasha, Della Rocca, Bianca, Di Natale, Chiara, D'Onofrio, Ettore, Espa, Irene, Fior, Giulia, Gancitano, Marta, Giordano, Barbara, Giusti, Laura, Grassi, Luigi, Guzzi, Pierluca, Isella, Celeste, Lax, Annamaria, Marano, Leonardo, Marconi, Federico, Marella, Marco, Metelli, Alessia, Michencig, Giulia, Miuli, Andrea, Moncada, Alessandro, Morello, Pietro, Moretti, Federico, Morreale, Marco, Mosca, Alessio, Nasti, Christian, Nosé, Michela, Ogheri, Filippo, Oresti, Margherita, Ornaghi, Alessandra, Palpella, Dario, Pancheri, Corinna, Papola, Davide, Passeri, Silvia, Pettorusso, Mauro, Piacenti, Susanna, Pinucci, Irene, Pugliese, Valentina, Purgato, Marianna, Rania, Marianna, Robbi, Federica, Romito, Samantha, Ronchi, Barbara, Roselli, Valentina, Segura-Garcia, Cristina, Signorelli, Maria Salvina, Simonelli, Gabriele, Sociali, Antonella, Sturiale, Serena, Tambelli, Antonio, Todesco, Beatrice, Trabucco, Alice, Turrini, Giulia, Villa, Veronica, Wiedenmann, Federico, Zambuto, Luca, Zanini, Elisa, Zannini, Chiara, and Zerbinati, Luigi

Abstract

Background: Major depressive disorder (MDD) is prevalent and disabling among older adults. Standing on its tolerability profile, vortioxetine might be a promising alternative to selective serotonin reuptake inhibitors (SSRIs) in such a vulnerable population. Methods: We conducted a randomised, assessor- and statistician-blinded, superiority trial including older adults with MDD. The study was conducted between 02/02/2019 and 02/22/2023 in 11 Italian Psychiatric Services. Participants were randomised to vortioxetine or one of the SSRIs, selected according to common practice. Treatment discontinuation due to adverse events after six months was the primary outcome, for which we aimed to detect a 12% difference in favour of vortioxetine. The study was registered in the online repository clinicaltrials.gov (NCT03779789). Findings: The intention-to-treat population included 179 individuals randomised to vortioxetine and 178 to SSRIs. Mean age was 73.7 years (standard deviation 6.1), and 264 participants (69%) were female. Of those on vortioxetine, 78 (44%) discontinued the treatment due to adverse events at six months, compared to 59 (33%) of those on SSRIs (odds ratio 1.56; 95% confidence interval 1.01–2.39). Adjusted and per-protocol analyses confirmed point estimates in favour of SSRIs, but without a significant difference. With the exception of the unadjusted survival analysis showing SSRIs to outperform vortioxetine, secondary outcomes provided results consistent with a lack of substantial safety and tolerability differences between the two arms. Overall, no significant differences emerged in terms of response rates, depressive symptoms and quality of life, while SSRIs outperformed vortioxetine in terms of cognitive performance. Interpretation: As opposed to what was previously hypothesised, vortioxetine did not show a better tolerability profile compared to SSRIs in older adults with MDD in this study. Additionally, hypothetical advantages of vortioxetine on depress

Published
2024

18. The Resistant Depression Response to Esketamine Assessing Metabolomics (ReDREAM) Project— Untargeted Metabolomics to Identify Biomarkers of Treatment Response to Intranasal Esketamine in Individuals with Treatment-Resistant Depression: A Study Protocol.

Author

Bartoli, Francesco, Cavaleri, Daniele, Riboldi, Ilaria, Crocamo, Cristina, de Filippis, Renato, Callegher, Riccardo Zandonella, Paglia, Giuseppe, Albert, Umberto, De Fazio, Pasquale, and Carrà, Giuseppe

Subjects
*AMINO acid metabolism, *MENTAL depression, *INTRANASAL medication, *METABOLOMICS, *ENERGY metabolism
Abstract

Objective: Treatment-resistant depression (TRD) affects around 20-30% of people with major depressive disorder. In 2019, esketamine nasal spray was approved for TRD by both the US Food and Drug Administration and the European Medicines Agency. While its clinical efficacy and safety are proven, the mechanisms underlying its antidepressant effect remain unclear. The use of metabolomics may allow understanding the metabolic effects of esketamine and predicting biological features associated with clinical response in TRD. Nonetheless, there is a lack of studies exploring the predictive value of metabolomics. The Resistant Depression Response to Esketamine Assessing Metabolomics (ReDREAM) project aims at identifying metabolic biosignatures that may represent novel correlates of response to esketamine treatment. Study Design: This is the protocol of an observational, prospective study. Methods: We plan to select 60 people with TRD from 3 clinical sites in Italy. The participants will be administered with esketamine nasal spray, following standard clinical practice, twice a week for 4 weeks (“induction phase”), then once a week for 4 additional weeks (“maintenance phase”). We will test the correlations between baseline metabolic profile and depressive symptom improvement at study endpoints (weeks 4 and 8) and we will explore the likelihood of different metabolic phenotypes between responders and non-responders. Expected results: An involvement of energy metabolism, amino acid metabolism, urea cycle, and nitric oxide synthesis in response to treatment with esketamine nasal spray is hypothesized. Conclusion: Unbiased data from untargeted metabolomics associated with clinical changes after esketamine treatment may contribute to define new paradigms for precision psychiatry-oriented, personalized care of TRD. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

19. Tolerability of vortioxetine compared to selective serotonin reuptake inhibitors in older adults with major depressive disorder (VESPA): a randomised, assessor-blinded and statistician-blinded, multicentre, superiority trial

Author

Ostuzzi, Giovanni, primary, Gastaldon, Chiara, additional, Tettamanti, Mauro, additional, Cartabia, Massimo, additional, Monti, Igor, additional, Aguglia, Andrea, additional, Aguglia, Eugenio, additional, Bartoli, Francesco, additional, Callegari, Camilla, additional, Canozzi, Andrea, additional, Carbone, Elvira Anna, additional, Carrà, Giuseppe, additional, Caruso, Rosangela, additional, Cavallotti, Simone, additional, Chiappini, Stefania, additional, Colasante, Fabrizio, additional, Compri, Beatrice, additional, D'Agostino, Armando, additional, De Fazio, Pasquale, additional, de Filippis, Renato, additional, Gari, Matteo, additional, Ielmini, Marta, additional, Ingrosso, Gianmarco, additional, Mammarella, Silvia, additional, Martinotti, Giovanni, additional, Rodolico, Alessandro, additional, Roncone, Rita, additional, Sterzi, Enrico, additional, Tarsitani, Lorenzo, additional, Tiberto, Elisa, additional, Todini, Liliana, additional, Amaddeo, Francesco, additional, D'Avanzo, Barbara, additional, Barbato, Angelo, additional, Barbui, Corrado, additional, Alessi, Maria Chiara, additional, Avincola, Gabriele, additional, Bachi, Bianca, additional, Bernasconi, Gianna, additional, Birgillito, Andrea, additional, Bisso, Emanuele, additional, Bonora, Stefano, additional, Calabrese, Angela, additional, Callovini, Tommaso, additional, Canestro, Aurelia, additional, Canonico, Salvo, additional, Capogrosso, Chiara Alessandro, additional, Carbone, Elvira, additional, Carosielli, Doriana, additional, Caselli, Ivano, additional, Cavaleri, Daniele, additional, Cavallotto, Clara, additional, Cesca, Marco, additional, Chiarenza, Cecilia, additional, Cioni, Riccardo Matteo, additional, Coloccini, Sara, additional, Cruciata, Marco, additional, Cumerlato, Claudia, additional, De Filippis, Renato, additional, De Palma, Manuela, additional, Del Vecchio, Sasha, additional, Della Rocca, Bianca, additional, Di Natale, Chiara, additional, D'Onofrio, Ettore, additional, Espa, Irene, additional, Fior, Giulia, additional, Gancitano, Marta, additional, Giordano, Barbara, additional, Giusti, Laura, additional, Grassi, Luigi, additional, Guzzi, Pierluca, additional, Isella, Celeste, additional, Lax, Annamaria, additional, Marano, Leonardo, additional, Marconi, Federico, additional, Marella, Marco, additional, Metelli, Alessia, additional, Michencig, Giulia, additional, Miuli, Andrea, additional, Moncada, Alessandro, additional, Morello, Pietro, additional, Moretti, Federico, additional, Morreale, Marco, additional, Mosca, Alessio, additional, Nasti, Christian, additional, Nosé, Michela, additional, Ogheri, Filippo, additional, Oresti, Margherita, additional, Ornaghi, Alessandra, additional, Ostuzzi, Giovanni, additional, Palpella, Dario, additional, Pancheri, Corinna, additional, Papola, Davide, additional, Passeri, Silvia, additional, Pettorusso, Mauro, additional, Piacenti, Susanna, additional, Pinucci, Irene, additional, Pugliese, Valentina, additional, Purgato, Marianna, additional, Rania, Marianna, additional, Robbi, Federica, additional, Romito, Samantha, additional, Ronchi, Barbara, additional, Roselli, Valentina, additional, Segura-Garcia, Cristina, additional, Signorelli, Maria Salvina, additional, Simonelli, Gabriele, additional, Sociali, Antonella, additional, Sturiale, Serena, additional, Tambelli, Antonio, additional, Todesco, Beatrice, additional, Trabucco, Alice, additional, Turrini, Giulia, additional, Villa, Veronica, additional, Wiedenmann, Federico, additional, Zambuto, Luca, additional, Zanini, Elisa, additional, Zannini, Chiara, additional, and Zerbinati, Luigi, additional

Published
2024
Full Text
View/download PDF

22. Breaking barriers into the future of (publishing in) psychiatry: The new truly Open Access journal empowering trainees

Author

Seker, Asilay, primary, Santos, Mario J., additional, Fernandes, Luis Afonso, additional, Zaja, Nikola, additional, Santos Martins, Filipa, additional, Tomasic, Lea, additional, King, Jacob, additional, Stirland, Lucy, additional, Ryland, Howard, additional, Markin, Kirill, additional, Kibitov, Andrey, additional, Sprengers, Jan, additional, Cavaleri, Daniele, additional, Pinto da Costa, Mariana, additional, Fiorillo, Andrea, additional, Leucht, Stefan, additional, Treasure, Janet, additional, and Sartorius, Norman, additional

Published
2023
Full Text
View/download PDF

23. First CINP Research Fellowship for Early Careers: Bridging Scientific Goals and Professional Networking

Author

Krivosova, M, Vellucci, L, Cavaleri, D, Afonso Fernandes, L, Leung, E, Gobbi, G, A. Grace, A, Ikeda, K, A. Oquendo, M, Vermetten, E, Zohar, J, Seker, A, Krivosova, Michaela, Vellucci, Licia, Cavaleri, Daniele, Afonso Fernandes, Luís, Leung, Edison, Gobbi, Gabriella, A. Grace, Anthony, Ikeda, Kazutaka, A. Oquendo, Maria, Vermetten, Eric, Zohar, Joseph, Seker, Asilay, Krivosova, M, Vellucci, L, Cavaleri, D, Afonso Fernandes, L, Leung, E, Gobbi, G, A. Grace, A, Ikeda, K, A. Oquendo, M, Vermetten, E, Zohar, J, Seker, A, Krivosova, Michaela, Vellucci, Licia, Cavaleri, Daniele, Afonso Fernandes, Luís, Leung, Edison, Gobbi, Gabriella, A. Grace, Anthony, Ikeda, Kazutaka, A. Oquendo, Maria, Vermetten, Eric, Zohar, Joseph, and Seker, Asilay

Abstract

Participating in scientific conferences and professional networking support productivity in research. However, there are barriers for early career scientists to benefit from these activities. In 2023, the International College of Neuropsychopharmacology (CINP) Committee for Early Careers organised the first edition of the CINP Research Fellowship for Early Careers to support international collaboration of junior neuroscientists and facilitate in-person exchange between early career and senior investigators. The programme included online and in-person sessions, the latter during the 34th CINP World Congress in Montreal. Selected fellows had the opportunity to learn and make round-table discussions with renowned scientists, including Professors Paola Dazzan, Alan Frazer, Gabriella Gobbi, Anthony Grace, Oliver Howes, Kazutaka Ikeda, Kazuyuki Nakagome, Maria Oquendo, Dan Rujescu, Eric Vermetten, and Joseph Zohar, enabling early career researchers to understand each mentor’s main scientific trajectory and research methodology. The underpinning aim to support the global networking of early career researchers was achieved through the programme, as evidenced by the ensuing collaborative projects.

Published
2023

24. Breaking barriers into the future of (publishing in) psychiatry: The new truly Open Access journal empowering trainees

Author

Seker, A, Santos, M, Fernandes, L, Zaja, N, Santos Martins, F, Tomasic, L, King, J, Stirland, L, Ryland, H, Markin, K, Kibitov, A, Sprengers, J, Cavaleri, D, Pinto da Costa, M, Fiorillo, A, Leucht, S, Treasure, J, Sartorius, N, Seker, Asilay, Santos, Mario J., Fernandes, Luis Afonso, Zaja, Nikola, Santos Martins, Filipa, Tomasic, Lea, King, Jacob, Stirland, Lucy, Ryland, Howard, Markin, Kirill, Kibitov, Andrey, Sprengers, Jan, Cavaleri, Daniele, Pinto da Costa, Mariana, Fiorillo, Andrea, Leucht, Stefan, Treasure, Janet, Sartorius, Norman, Seker, A, Santos, M, Fernandes, L, Zaja, N, Santos Martins, F, Tomasic, L, King, J, Stirland, L, Ryland, H, Markin, K, Kibitov, A, Sprengers, J, Cavaleri, D, Pinto da Costa, M, Fiorillo, A, Leucht, S, Treasure, J, Sartorius, N, Seker, Asilay, Santos, Mario J., Fernandes, Luis Afonso, Zaja, Nikola, Santos Martins, Filipa, Tomasic, Lea, King, Jacob, Stirland, Lucy, Ryland, Howard, Markin, Kirill, Kibitov, Andrey, Sprengers, Jan, Cavaleri, Daniele, Pinto da Costa, Mariana, Fiorillo, Andrea, Leucht, Stefan, Treasure, Janet, and Sartorius, Norman

Abstract

The European Journal of Psychiatric Trainee is the official journal of the European Federation of Psychiatric Trainees. It is a fully open-access peer-reviewed scientific journal which will prioritize work by psychiatric trainees while also publishing a wide range of papers on mental health by other authors from diverse professional backgrounds. This editorial marks the first issue of the European Journal of Psychiatric Trainees and outlines its vision, mission and the articles this issue includes. It is the hope of the editorial board that this issue and the future ones reach a wide network of readers with original, informative and engaging papers.

Published
2023

25. Long-acting injectable antipsychotics for the treatment of bipolar disorder: evidence from mirror-image studies

Author

Bartoli, F, Cavaleri, D, Nasti, C, Palpella, D, Guzzi, P, Riboldi, I, Crocamo, C, Pappa, S, Carrà, G, Bartoli, Francesco, Cavaleri, Daniele, Nasti, Christian, Palpella, Dario, Guzzi, Pierluca, Riboldi, Ilaria, Crocamo, Cristina, Pappa, Sofia, Carrà, Giuseppe, Bartoli, F, Cavaleri, D, Nasti, C, Palpella, D, Guzzi, P, Riboldi, I, Crocamo, C, Pappa, S, Carrà, G, Bartoli, Francesco, Cavaleri, Daniele, Nasti, Christian, Palpella, Dario, Guzzi, Pierluca, Riboldi, Ilaria, Crocamo, Cristina, Pappa, Sofia, and Carrà, Giuseppe

Abstract

Clinical trials and real-world data have shown that long-acting injectable antipsychotics (LAIs) might be an effective therapeutic option also for people with bipolar disorder (BD). However, complementing evidence from mirror-image studies investigating LAIs in BD is scattered and has not been systematically evaluated so far. We thus performed a review of observational mirror-image studies testing the effectiveness of LAI treatment on clinical outcomes in people with BD. Embase, MEDLINE, and PsycInfo electronic databases were systematically searched (via Ovid) up to November 2022. We included six mirror-image studies that compared relevant clinical outcomes between the 12-months after (post-treatment period) and the 12-months before (pre-treatment period) the initiation of a LAI treatment in adults with BD. We found that LAI treatment is associated with a significant reduction in days spent in hospital and number of hospitalizations. Moreover, LAI treatment seems to be associated with a significant decrease in the proportion of individuals with at least one hospital admission, even though data on this outcome were reported by just two studies. In addition, studies consistently estimated a significant reduction of hypo-/manic relapses after LAI treatment initiation, while the effect of LAIs for depressive episodes is less clear. Finally, LAI treatment initiation was associated with a lower number of emergency department visits in the year after LAI initiation. The findings of this review seem to suggest that the use of LAIs is an effective strategy to improve major clinical outcomes in people with BD. Nonetheless, additional research, based on standardized assessments of prevalent polarity and relapses, is needed to identify the clinical characteristics of individuals with BD who are most likely to benefit from a LAI treatment.

Published
2023

26. Effect of long-acting injectable antipsychotics on 1-year hospitalization in bipolar disorder: a mirror-image study

Author

Bartoli, F, Callovini, T, Cavaleri, D, Crocamo, C, Riboldi, I, Aguglia, A, De Fazio, P, Martinotti, G, D'Agostino, A, Ostuzzi, G, Barbui, C, Carrà, G, Bartoli, Francesco, Callovini, Tommaso, Cavaleri, Daniele, Crocamo, Cristina, Riboldi, Ilaria, Aguglia, Andrea, De Fazio, Pasquale, Martinotti, Giovanni, D'Agostino, Armando, Ostuzzi, Giovanni, Barbui, Corrado, Carrà, Giuseppe, Bartoli, F, Callovini, T, Cavaleri, D, Crocamo, C, Riboldi, I, Aguglia, A, De Fazio, P, Martinotti, G, D'Agostino, A, Ostuzzi, G, Barbui, C, Carrà, G, Bartoli, Francesco, Callovini, Tommaso, Cavaleri, Daniele, Crocamo, Cristina, Riboldi, Ilaria, Aguglia, Andrea, De Fazio, Pasquale, Martinotti, Giovanni, D'Agostino, Armando, Ostuzzi, Giovanni, Barbui, Corrado, and Carrà, Giuseppe

Abstract

Long-acting injectable (LAI) antipsychotics are often used for the long-term management also of bipolar disorder (BD). Nonetheless, evidence on their effect on pragmatic outcomes such as hospitalization risk in BD is inconsistent. We carried out a mirror-image study comparing rates and number of days of hospitalization, one year before and after the initiation of LAI treatment, in a sample of subjects with BD. Participants were selected from the STAR Network Depot Study, a pragmatic, observational, multicenter research involving a cohort of inpatients and outpatients consecutively started on LAI treatment. Variations in rates and in total number of days of hospitalization between the 12 months before and those after treatment initiation were analyzed. Among 461 individuals screened for eligibility, we included 71 adults with BD, initiated either on first- (FGA) or second-generation (SGA) LAIs. We found a significant decrease in terms of 12-month hospitalization rates (p < 0.001) and number of days (p < 0.001) after LAI initiation, without any effect by age, gender, alcohol/substance use disorders, and symptom severity. Subgroup analyses based on antipsychotic class, history of LAI treatment, and concomitant oral medications, confirmed the decreasing trend on both hospitalization rates and number of days. However, these reductions were not significant among participants who continued this treatment for less than 6 months. Comprehensively, this study supports the role of LAIs as effective maintenance treatment options for BD. Further research is needed to identify clinical characteristics of people with BD who would most benefit from long-acting formulations of antipsychotics.

Published
2023

28. Practical Guidance for the Use of Long-Acting Injectable Antipsychotics in the Treatment of Schizophrenia

Author

Riboldi,Ilaria, Cavaleri,Daniele, Capogrosso,Chiara A, Crocamo,Cristina, Bartoli,Francesco, and Carrà ,Giuseppe

Subjects
Psychology Research and Behavior Management
Abstract

Ilaria Riboldi,1 Daniele Cavaleri,1 Chiara A Capogrosso,1 Cristina Crocamo,1 Francesco Bartoli,1 Giuseppe Carrà 1,2 1Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; 2Division of Psychiatry, University College London, London, UKCorrespondence: Ilaria Riboldi, Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, Monza, 20900, Italy, Tel +39 0257998647, Email i.riboldi1@campus.unimib.itAbstract: Schizophrenia is a severe mental illness causing a high degree of disability. First- and second-generation antipsychotics (FGAs and SGAs) represent key resources for its acute and long-term management. Since a poor adherence to oral treatments may negatively impact the course of the disorder, long-acting injectable antipsychotics (LAIs) are often used to reduce clinical relapses. Notwithstanding their potential beneficial features, LAIs use in clinical practice remains somewhat hampered by the limited amount of relevant systematic information. This review thus aims at providing a clinical, practical guidance for the use of LAIs in the treatment of schizophrenia. We synthetized main information on indications, dosage, and administration of LAIs approved by the US Food and Drug Administration (FDA) and/or in EU countries, as well as evidence from the most recent systematic reviews and meta-analyses. Currently available information, though heterogeneous, shows that LAIs can prevent relapses and rehospitalizations, improving clinical outcomes and favouring sustained remission among people with schizophrenia. The use of SGA LAIs is supported by more robust evidence than FGA LAIs. Along with their positive impact on the prevention of treatment discontinuation, some LAIs might also enhance individual global functioning and quality of life, without additional adverse events or health-care costs, as compared with oral antipsychotics. Although which LAIs can be considered a first-choice option, as well as their superiority over oral antipsychotics, remain unclear issues, this review offers a comprehensive overview of information available on the use of LAIs for people with schizophrenia, providing clinicians with practical guidance in terms of efficacy and acceptability of single agents. Literature gaps and future research needs are also described.Keywords: antipsychotic agents, injections, guidelines, schizophrenia

Published
2022

29. The peripheral blood levels of neopterin, biopterin, and tetrahydrobiopterin in depression: a systematic review and meta-analysis

Author

Cavaleri, Daniele

Subjects
Serum, BH4, Tetrahydrobiopterin, Neuroscience and Neurobiology, Mental and Social Health, Depression, Life Sciences, Psychiatry and Psychology, Immunopathology, Other Neuroscience and Neurobiology, Biopterin, Neopterin, Meta-analysis, Plasma, Blood, Medicine and Health Sciences, Molecular and Cellular Neuroscience, Psychiatric and Mental Health, Systematic Review, Biochemistry, Biophysics, and Structural Biology, Immunology and Infectious Disease
Abstract

Abnormalities in the tetrahydrobiopterin synthesis pathway have been described in depression. Research has reported inconsistent and conflicting findings so far, and no systematic synthesis of existing evidence is available. We will conduct a systematic review and meta-analysis of observational studies aimed at investigating the peripheral blood levels of neopterin, biopterin, and tetrahydrobiopterin (BH4) in individuals with depression as compared with those of subjects without mental disorders (healthy controls – HCs).

Published
2022
Full Text
View/download PDF

30. Protocol: systematic review of randomized controlled trials of psychological interventions in university students during the COVID-19 pandemic

Author

Cavaleri, Daniele

Subjects
systematic review, university, Medicine and Health Sciences, psychological interventions, COVID-19, Psychiatry and Psychology, Other Psychiatry and Psychology
Abstract

The COVID-19 pandemic has undoubtedly affected the psychological well-being of youths and students, particularly among those studying at university, frequently living alone and being burdened by performance-related anxiety and depression. As a consequence, identifying those interventions that can be beneficial on the mental health of these individuals stands out as a crucial issue. We will perform a systematic review of the existing evidence on psychological interventions on university students by synthesizing data from randomized controlled studies conducted during the COVID-19 emergency.

Published
2022
Full Text
View/download PDF

31. Clinical correlates of Attention Deficit-Hyperactivity Disorder comorbidity in individuals suffering from Bipolar Disorder: a meta-analysis

Author

Cavaleri, Daniele

Subjects
Bipolar Disorder, Neuroscience and Neurobiology, Mental and Social Health, Mental Disorders, Life Sciences, Psychiatry and Psychology, Other Neuroscience and Neurobiology, behavioral disciplines and activities, Other Psychiatry and Psychology, meta-analysis, Other Life Sciences, mental disorders, Medicine and Health Sciences, Psychiatric and Mental Health, Attention Deficit-Hyperactivity Disorder
Abstract

Attention Deficit-Hyperactivity Disorder (ADHD) is a frequently concurrent condition in Bipolar Disorder (BD). We will conduct a meta-analysis of observational studies aimed at identifying the clinical characteristics of adults with BD-ADHD comorbidity as compared with those suffering from BD alone.

Published
2022
Full Text
View/download PDF

32. Clinical correlates of Attention Deficit-Hyperactivity Disorder comorbidity in individuals suffering from Bipolar Disorder: a meta-analysis

Author

Bartoli, Francesco, callovini, tommaso, Cavaleri, Daniele, Riboldi, Ilaria, Cioni, Riccardo, Bachi, Bianca, Calabrese, Angela, Moretti, Federico, Canestro, Aurelia, Morreale, Marco, Nasti, Christian, Palpella, Dario, Piacenti, Susanna, Nacinovich, Renata, Crocamo, Cristina, and Carrà, Giuseppe

Subjects
Bipolar Disorder, Neuroscience and Neurobiology, Mental and Social Health, Mental Disorders, Life Sciences, Psychiatry and Psychology, Other Neuroscience and Neurobiology, behavioral disciplines and activities, Other Psychiatry and Psychology, meta-analysis, Other Life Sciences, mental disorders, Medicine and Health Sciences, Psychiatric and Mental Health, Attention Deficit-Hyperactivity Disorder
Abstract

Attention Deficit-Hyperactivity Disorder (ADHD) is a frequently concurrent condition in Bipolar Disorder (BD). We will conduct a meta-analysis of observational studies aimed at identifying the clinical characteristics of adults with BD-ADHD comorbidity as compared with those suffering from BD alone.

Published
2022
Full Text
View/download PDF

33. Prevalence and correlates of anxiety and depressive symptoms in international university students during the COVID-19 pandemic: a systematic review

Author

Riboldi, Ilaria, Capogrosso, Chiara, Piacenti, Susanna, Calabrese, Angela, Cavaleri, Daniele, Paioni, Susanna, Bartoli, Francesco, Crocamo, Cristina, and Carrà, Giuseppe

Subjects
education
Abstract

The unexpected circumstances regarding the COVID-19 pandemic may have a detrimental effect on the mental health of university students. Compared to domestic students, international ones could have faced greater difficulties in sustaining their mental health during the COVID-19 pandemic. The following factors are likely to exacerbate these adversities: language barriers, economic pressure, living abroad status, adaptation to the host country’s culture, and the lack of access to local health care and social support systems. We will perform a systematic review of the existing evidence on the prevalence and the correlates of anxiety and depressive symptoms in international university students by synthesizing data from studies conducted during the COVID-19 emergency.

Published
2022
Full Text
View/download PDF

34. Blood concentrations of pituitary hormones in first-episode, drug-naïve psychosis: a systematic review and meta-analysis

Author

Cavaleri, Daniele, Bartoli, Francesco, Capogrosso, Chiara, Guzzi, Pierluca, Bernasconi, Gianna, Re, Martina, Crocamo, Cristina, Carrà, Giuseppe, and Misiak, Blazej

Subjects
Mental and Social Health, Medicine and Health Sciences, Psychiatric and Mental Health, #pituitary, #first-episode psychosis, #systematic review, #meta-analysis
Abstract

Several abnormalities in pituitary functionality have been described in subjects with first episode, drug-naïve psychosis. Research has reported inconsistent and conflicting findings so far, and no systematic synthesis of the existing evidence is available. We will conduct a systematic review and meta-analysis of observational studies investigating blood concentrations of anterior pituitary hormones – namely adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) – in drug-naïve (or minimally treated) individuals with first-episode psychosis (FEP) as compared with those of healthy controls (HCs).

Published
2022
Full Text
View/download PDF

35. Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Author

Bartoli, Francesco, primary, Callovini, Tommaso, additional, Cavaleri, Daniele, additional, Cioni, Riccardo Matteo, additional, Bachi, Bianca, additional, Calabrese, Angela, additional, Moretti, Federico, additional, Canestro, Aurelia, additional, Morreale, Marco, additional, Nasti, Christian, additional, Palpella, Dario, additional, Piacenti, Susanna, additional, Nacinovich, Renata, additional, Riboldi, Ilaria, additional, Crocamo, Cristina, additional, and Carrà, Giuseppe, additional

Published
2022
Full Text
View/download PDF

36. Practical Guidance for the Use of Long-Acting Injectable Antipsychotics in the Treatment of Schizophrenia

Author

Riboldi, I, Cavaleri, D, Capogrosso, C, Crocamo, C, Bartoli, F, Carrà, G, Riboldi, Ilaria, Cavaleri, Daniele, Capogrosso, Chiara A, Crocamo, Cristina, Bartoli, Francesco, Carrà, Giuseppe, Riboldi, I, Cavaleri, D, Capogrosso, C, Crocamo, C, Bartoli, F, Carrà, G, Riboldi, Ilaria, Cavaleri, Daniele, Capogrosso, Chiara A, Crocamo, Cristina, Bartoli, Francesco, and Carrà, Giuseppe

Abstract

Schizophrenia is a severe mental illness causing a high degree of disability. First-and second-generation antipsychotics (FGAs and SGAs) represent key resources for its acute and long-term management. Since a poor adherence to oral treatments may negatively impact the course of the disorder, long-acting injectable antipsychotics (LAIs) are often used to reduce clinical relapses. Notwithstanding their potential beneficial features, LAIs use in clinical practice remains somewhat hampered by the limited amount of relevant systematic information. This review thus aims at providing a clinical, practical guidance for the use of LAIs in the treatment of schizophrenia. We synthetized main information on indications, dosage, and administration of LAIs approved by the US Food and Drug Administration (FDA) and/or in EU countries, as well as evidence from the most recent systematic reviews and meta-analyses. Currently available information, though heterogeneous, shows that LAIs can prevent relapses and rehospitalizations, improving clinical outcomes and favouring sustained remission among people with schizophrenia. The use of SGA LAIs is supported by more robust evidence than FGA LAIs. Along with their positive impact on the prevention of treatment discontinuation, some LAIs might also enhance individual global functioning and quality of life, without additional adverse events or health-care costs, as compared with oral antipsychotics. Although which LAIs can be considered a first-choice option, as well as their superiority over oral antipsychotics, remain unclear issues, this review offers a comprehensive overview of information available on the use of LAIs for people with schizophrenia, providing clinicians with practical guidance in terms of efficacy and acceptability of single agents. Literature gaps and future research needs are also described.

Published
2022

38. sj-docx-1-anp-10.1177_00048674221106669 – Supplemental material for Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Author

Bartoli, Francesco, Callovini, Tommaso, Cavaleri, Daniele, Cioni, Riccardo Matteo, Bachi, Bianca, Calabrese, Angela, Moretti, Federico, Canestro, Aurelia, Morreale, Marco, Nasti, Christian, Palpella, Dario, Piacenti, Susanna, Nacinovich, Renata, Riboldi, Ilaria, Crocamo, Cristina, and Carrà, Giuseppe

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-docx-1-anp-10.1177_00048674221106669 for Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis by Francesco Bartoli, Tommaso Callovini, Daniele Cavaleri, Riccardo Matteo Cioni, Bianca Bachi, Angela Calabrese, Federico Moretti, Aurelia Canestro, Marco Morreale, Christian Nasti, Dario Palpella, Susanna Piacenti, Renata Nacinovich, Ilaria Riboldi, Cristina Crocamo and Giuseppe Carrà in Australian & New Zealand Journal of Psychiatry

Published
2022
Full Text
View/download PDF

41. Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis.

Author

Bartoli, Francesco, Callovini, Tommaso, Cavaleri, Daniele, Cioni, Riccardo Matteo, Bachi, Bianca, Calabrese, Angela, Moretti, Federico, Canestro, Aurelia, Morreale, Marco, Nasti, Christian, Palpella, Dario, Piacenti, Susanna, Nacinovich, Renata, Riboldi, Ilaria, Crocamo, Cristina, and Carrà, Giuseppe

Subjects
PSYCHOLOGY information storage & retrieval systems, META-analysis, MEDICAL information storage & retrieval systems, SUBSTANCE abuse, SYSTEMATIC reviews, ATTENTION-deficit hyperactivity disorder, SUICIDAL behavior, SEX distribution, DESCRIPTIVE statistics, EMPLOYMENT, SOCIODEMOGRAPHIC factors, MEDLINE, ODDS ratio, MARITAL status, BIPOLAR disorder, COMORBIDITY, SYMPTOMS, ADULTS
Abstract

Objective: Attention deficit hyperactivity disorder is a frequent comorbid condition in adults with bipolar disorder. We performed a meta-analysis aimed at assessing sociodemographic and clinical correlates of attention deficit hyperactivity disorder in bipolar disorder. Method: We searched main electronic databases up to June 2021. Random-effects meta-analyses, with relevant meta-regression and quality-based sensitivity analyses, were carried out to estimate the association between attention deficit hyperactivity disorder and putative correlates, grading the quality of evidence. Results: We included 43 studies, based on 38 independent samples. Attention deficit hyperactivity disorder participants were more likely to be males (odds ratio = 1.46; p < 0.001) and unemployed (odds ratio = 1.45; p = 0.045), and less likely to be married (odds ratio = 0.62; p = 0.014). They had an earlier onset of bipolar disorder (standardized mean difference = −0.36; p < 0.001); more mood episodes (standardized mean difference = 0.35; p = 0.007), particularly depressive (standardized mean difference = 0.30; p = 0.011) and mixed (standardized mean difference = 0.30; p = 0.031) ones; higher odds of using antidepressants (odds ratio = 1.80; p = 0.024) and attempted suicides (odds ratio = 1.83; p < 0.001) and lower odds of psychotic features (odds ratio = 0.63; p = 0.010). Moreover, they were more likely to have generalized anxiety disorder (odds ratio = 1.50; p = 0.019), panic disorder (odds ratio = 1.89; p < 0.001), social phobia (odds ratio = 1.61; p = 0.017), eating disorders (odds ratio = 1.91; p = 0.007), antisocial personality disorder (odds ratio = 3.59; p = 0.004) and substance (odds ratio = 2.29; p < 0.001) or alcohol (odds ratio = 2.28; p < 0.001) use disorders. Quality of the evidence was generally low or very low for the majority of correlates, except for bipolar disorder onset and alcohol/substance use disorders (high), and suicide attempts (moderate). Conclusion: Comorbid bipolar disorder/attention deficit hyperactivity disorder may have some distinctive clinical features including an earlier onset of bipolar disorder and higher comorbid alcohol/substance use disorder rates. Further research is needed to identify additional clinical characteristics of this comorbidity. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

44. Some of us are most at risk: Systematic Review and Meta-Analysis of correlates of depressive symptoms among healthcare workers during the SARS-CoV-2 outbreak

Author

Crocamo, C, Bachi, B, Calabrese, A, Callovini, T, Cavaleri, D, Cioni, R, Moretti, F, Bartoli, F, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Calabrese, Angela, Callovini, Tommaso, Cavaleri, Daniele, Cioni, Riccardo M., Moretti, Federico, Bartoli, Francesco, Carrà, Giuseppe, Crocamo, C, Bachi, B, Calabrese, A, Callovini, T, Cavaleri, D, Cioni, R, Moretti, F, Bartoli, F, Carrà, G, Crocamo, Cristina, Bachi, Bianca, Calabrese, Angela, Callovini, Tommaso, Cavaleri, Daniele, Cioni, Riccardo M., Moretti, Federico, Bartoli, Francesco, and Carrà, Giuseppe

Abstract

The COVID-19 pandemic has had a severe psychosocial impact on healthcare workers (HCWs). This systematic review and meta-analysis aimed at evaluating the association between individual features and depressive symptoms reported by HCWs during the pandemic. We searched Medline, Embase, and PsycInfo up to 23 June 2020. We included cross-sectional studies testing the association between individual correlates and depressive symptoms in HCWs during the SARS-CoV-2 outbreak. Fourteen studies met inclusion criteria, involving 14,173 HCWs (3,070 with depressive symptoms). Women (OR = 1.50; 95 %CI: 1.28–1.76; I2 = 40.0 %), individuals with suspected/confirmed COVID-19 (OR = 2.10; 95 %CI: 1.64–2.69; I2 = 0 %), and those with an infected family member or friend (OR = 1.67; 95 %CI: 1.37–2.04; I2 = 0%) were more likely to report depressive features, which, instead, were less frequent among doctors (compared with nurses) (OR = 0.80; 95 %CI: 0.66–0.98; I2 = 48.2 %) and HCWs who felt adequately protected (OR = 0.48; 95 %CI: 0.32–0.72; I2 = 36.3 %). Our study provided timely evidence on the correlates of depressive symptoms among HCWs during the pandemic. Early screening is crucial to develop tailored health interventions, redesigning the response to COVID-19.

Published
2021

46. Pre-Discharge Predictors of 1-Year Rehospitalization in Adolescents and Young Adults with Severe Mental Disorders: A Retrospective Cohort Study

Author

Bartoli, Francesco, primary, Cavaleri, Daniele, additional, Moretti, Federico, additional, Bachi, Bianca, additional, Calabrese, Angela, additional, Callovini, Tommaso, additional, Cioni, Riccardo M., additional, Riboldi, Ilaria, additional, Nacinovich, Renata, additional, Crocamo, Cristina, additional, and Carrà, Giuseppe, additional

Published
2020
Full Text
View/download PDF

49. Biomolecular Research on Electroconvulsive Therapy for Mental Disorders: State of the Art and Future Directions.

Author

Cavaleri, Daniele and Bartoli, Francesco

Subjects
*ELECTROCONVULSIVE therapy, *MENTAL illness, *CATATONIA, *ACUTE stress disorder
Abstract

An editorial is presented on unique role of ECT in the management of treatment-refractory psychiatric conditions attributable to the potential higher efficacy over standard psychopharmacological treatments. Topics include stigma, lack of knowledge of modern ECT techniques, and concerns about the safety, primarily regarding cognition; and analyzing the effects of ECT on markers of oxidative stress in both experimental models and humans with major mental disorders.

Published
2022
Full Text
View/download PDF

50. Digital mental health interventions for anxiety and depressive symptoms in university students during the COVID-19 pandemic: A systematic review of randomized controlled trials

Author

Riboldi, Ilaria, Cavaleri, Daniele, Calabrese, Angela, Capogrosso, Chiara Alessandra, Piacenti, Susanna, Bartoli, Francesco, Crocamo, Cristina, and Carrà, Giuseppe

Abstract

Los estudiantes universitarios son particularmente vulnerables a los problemas de salud mental, siendo la ansiedad y la depresión las condiciones más comunes. Durante la pandemia de COVID-19, el distanciamiento social, el autoaislamiento y las dificultades relacionadas con la enseñanza y el aprendizaje en línea han aumentado su carga de ansiedad y síntomas depresivos. Así, la urgente necesidad de intervenir a favor de estos sujetos vulnerables, junto con las dificultades para realizar intervenciones presenciales a causa de los confinamientos y restricciones, ha llevado a priorizar estrategias de salud mental digital. Este estudio tuvo como objetivo revisar sistemáticamente la literatura existente sobre intervenciones digitales de salud mental dirigidas a la ansiedad y los síntomas depresivos en estudiantes universitarios durante la emergencia de COVID-19. Las búsquedas sistemáticas en las bases de datos Medline, Embase y PsycInfo identificaron ocho ensayos controlados aleatorios. Con respecto a los síntomas de ansiedad, la terapia cognitiva conductual, la terapia conductual dialéctica y las técnicas de práctica mente-cuerpo entregadas digitalmente surgieron como estrategias válidas, mientras que la psicología positiva digital y las intervenciones basadas en el mindfulness mostraron resultados mixtos. Por otro lado, la terapia conductual dialéctica y las intervenciones de psicología positiva proporcionadas digitalmente han demostrado cierta eficacia en la reducción de los síntomas depresivos. En general, la literatura disponible, aunque de baja calidad, parece respaldar el papel de las intervenciones digitales en la promoción de la salud mental de los estudiantes universitarios durante la pandemia de COVID-19.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results