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4. COVID-19 - O VÍRUS QUE MOVIMENTOU A CIÊNCIA - VOLUME 2

Author

Duarte, Fábio Biguelini, primary, Dutra, Angélica Paula Barbosa Silva, additional, Freitas, Guilherme Vasconcelos de, additional, Fukuoka, Vitória Morita, additional, Guimarães, Lizandra Ferrari, additional, Moeller, Amanda Gonçalves, additional, Oliveira, Fabiana de, additional, Paz, Adriana Aparecida, additional, Seroiska, Gabriel, additional, Silva, André Luiz da, additional, SARAIVA, GABRIEL BEZERRA DO NASCIMENTO, additional, PONTES, AMANDA DAIANA, additional, SALIN, ADRIANE BONOTTO, additional, FREIRE, ALINE ARAUJO MAIA MIOLA, additional, SOUZA, LUANA RODRIGUES MARQUES DE, additional, SOUZA, CAMILA DE OLIVEIRA, additional, OLIVEIRA, CLARA GOMES DE, additional, MORENO, DIEGO LEÃO ARAÚJO, additional, ALMEIDA, EMILE PEREIRA, additional, SANTOS, GUILHERME AUGUSTO DE ARAÚJO, additional, SOARES, RAFAELA DA SILVA, additional, SARTOR, LUIGI AURELIO, additional, Barcelos, João P P, additional, FERNANDES, JOÃO PAULO ARGENTON, additional, MAGALHÃES, JOÃO VICTOR STARLING, additional, BANDEIRA, LORENA DE SOUZA, additional, CUNHA, LUCAS LANNA, additional, TURCI, MARIA APARECIDA, additional, WINKLER, INGRED, additional, SILVA, THAÍS DA, additional, FREITAS, DANIELLE DA PAIXÃO, additional, SILVA, LAVÍNIA FERREIRA DA, additional, MOREIRA, ALINE MORAIS, additional, FARIA, CECÍLIA ALMEIDA E AMARAL, additional, MOREIRA, RAISSA DE SOUZA MERCEDO, additional, LEITE, THARICK ANTÔNIO XAVIER DE OLIVEIRA, additional, CRUZ, YOLANDA VALOIS CHAGAS, additional, Lima, Maria Adriely Cunha, additional, SANTOS, EVELEN ROUSE DE SOUZA, additional, CESTARI, YASMIM LAILA FRAGOSO, additional, SANTOS, ISABELA DE MOURA, additional, VIEIRA, THAÍS FRANCIELLE SANTANA, additional, SOUSA, LARYSSA FIALHO DE OLIVEIRA, additional, SOUZA, CAMILLA RADIMACK SANTOS DE, additional, NASCIMENTO, MONALYSA DA CRUZ, additional, REZENDE, MATEUS LENIER, additional, OLIVEIRA, HALLEY FERRARO, additional, RIBEIRO, DANIELLA DE LOURDES BAGGIO REHFELD, additional, FERREIRA, SOFIA GONÇALVES, additional, SADER, LUÍSA MACHADO CAMPOLINA, additional, RODRIGUES, EMANUELA CARVALHO, additional, PEREIRA, LUÍSA BAMBIRRA, additional, BOAVENTURA, JÚLIA VELOSO, additional, RODRIGUES, MARIANNE NETO, additional, SCHERRER, ISABELA RESENDE SILVA, additional, SILVEIRA, PRISCILA FARIAS DA, additional, SIMÃO, FELIPE PRAUN, additional, CAREGNATO, NATHALIA, additional, SOUZA, PHELIPE S, additional, Araujo, Maria Isadora Benedito de, additional, Mamede, Iascara Vitória de Oliveira, additional, Braga, Francisca Ivina Leite, additional, Nascimento, José Paulo Lima do, additional, Silva, Marcos Paulo Da, additional, Lourenço, Heitor Fernandes, additional, Ribeiro, Luana da Hora, additional, Duarte, Rany Magnaelle Rodrigues, additional, Araujo, Luciana Mara Peixoto, additional, Almeida, Bárbara M P De, additional, SANTOS, ELLEN ARAUJO, additional, Filippetti, Eloah P, additional, CARVALHO, GABRIELA BARTANHA, additional, OLIVEIRA, RAQUEL ZECHETTI DE, additional, CARDOSO, RENATA ARAUJO, additional, RATTI, ANA FLÁVIA SACURRATO, additional, BASTIANELLO, FERNANDA, additional, MENDES, MAYARA, additional, FERNANDES, ALEXANDRE PEREIRA, additional, BARSOTTI, NATHALIA SILVEIRA, additional, Santos, Larissa R, additional, Bastos, Ariane Lopes, additional, Filippetti, Eloah Pascuotte, additional, Batista, Lysa Laura Figueiredo, additional, Damaia, Pedro Batistel, additional, Almeida, Vitor Amaral de, additional, Araújo, Ana Carolina Vieira, additional, Dumas, Juliana Cedro de Souza, additional, COSTA, LOUISE VICTORIA VIEIRA TOSTA DA, additional, Silva, Ana Carina Faleta De Aquino, additional, MOREIRA, EMANUELLE ALVES, additional, SANTOS, FLÁVIO CAMPAGNOLI DOS, additional, Costa, João Paulo Dias, additional, SANTOS, RAFAELLY DOS, additional, SANTANA, STEFANNY RAFAELA DE, additional, SIQUEIRA, YGOR RIBEIRO, additional, CAVALCANTE, RAFAEL CIRO MARQUES, additional, MIRANDA, RENATA, additional, FERNANDES, ÍTALO RUFINO DE QUEIROZ, additional, OLIVEIRA, MARCOS DIVINO DE, additional, Oliveira, Maria Eduarda Ferreira de, additional, Sampaio, Matheus Vieira, additional, FONSECA, WEILER FERREIRA, additional, Sobrinho, Weberton Dorásio, additional, Silva, João Lucas Rocha, additional, Formiga, Rafaela Carneiro de Almeida, additional, Camurça, Alessandra Bezerra de Almeida, additional, Facundo, Andressa Lisboa de Carvalho, additional, Gadelha, Ana Beatriz Freire, additional, Basto, Giovana Lins, additional, Leite, Lara Horta de Araújo, additional, Pedrosa, Pedro Palitot Pereira, additional, Costa, Rayane Mendonça da, additional, Camurça, Tainah Braga, additional, COSTA, YANNE GONÇALVES FERNANDES DA, additional, CAVALCANTI, MATHEUS DE ALMEIDA MURITIBA PORTELLA, additional, NOVAIS, THALLYS HENRIQUE DE OLIVEIRA, additional, NASCIMENTO, PEDRO HENRIQUE BRANDÃO DO, additional, MELO, IZABEL ROCHA DE, additional, MARQUES, THAÍS RAPOSO, additional, ALMEIDA, LETÍCIA MARIA PERRELLI RAMALHO DE, additional, SILVA, JÉSSICA BARBOSA MAIA DA, additional, BARBOSA, ARIANNA GONÇALVES, additional, SILVA, ALVARO BULHÕES DA, additional, Pereira, Lívia Leandro de Souza, additional, CAVALCANTI, BIANCA FRANCINE FERREIRA, additional, SILVA, GEOVANI ANDRIEL ALVES MARTINIANO DA, additional, STANFORD, GUSTAVO DE ALBUQUERQUE, additional, SANTANA, LETÍCIA KELLY MELO, additional, OLIVEIRA, MARIA EDUARDA TAVARES DE, additional, MARAFANTE, MARIA EDUARDA OSÓRIO, additional, Neves, Othilio Johanes Leite Ciraulo Ismael da Costa, additional, SILVA, MARIA FERNANDA LUZ, additional, AGUIAR, MILENA MARIA DA SILVA, additional, PENHA, WESLLEY JONATHAN LOPES DA, additional, BARROS, ANDRÉ LUIZ SOUZA, additional, ROCHA, GABRIELA ALMEIDA, additional, ROCHA, DANIELA ALMEIDA, additional, SANTOS, FILIPE VIANA, additional, FREITAS, GABRIEL BARBOSA DE, additional, COSTA, HENRIQUE REIS RABELO, additional, SILVA, LAIS GUSMÃO, additional, Hawerroth, Mayara Santana, additional, TOLENTINO, SOFIA LANNES, additional, MARTINS, THAYSA DRUMMOND, additional, RODRIGUES, VICTOR MUNIZ, additional, ASSIS, PEDRO IVO COSTA MORAIS DE, additional, ASSIS, VIVIAN COSTA MORAIS DE, additional, ROSA, LUIZA MARINHO MOTTA SANTA, additional, CISCOTTO, PAULA HENRIQUES CRUZ, additional, CRUZ, ANA BEATRIZ NOGUEIRA DA, additional, BRITO, GABRIELA SILVA DE, additional, ROSADO, LARA ANDRADE, additional, LOPES, LUIZA WANDERLEY PERSIANO, additional, CASSUNDÉ, MATHEUS ALHEIROS, additional, MENDONÇA, ARTHUR FARIA, additional, PERILLO, ANA LUISA PEREIRA, additional, SOUZA, ANA CAROLINE NOGUEIRA DE MOREIRA, additional, MATOS, ANDREA DE FARIA REZENDE, additional, JUBÉ, CAMILLA MACHADO FLEURY, additional, SILVA, DÉBORA CRISTINA RIBEIRO DA, additional, ROSA, HENRIQUE DANIN ARAÚJO, additional, OLIVEIRA, JESSYCA ZANELLA FERREIRA DE, additional, BORGES, JORDANA ARAÚJO, additional, ROSA, SUÉLIA DE SIQUEIRA RODRIGUES FLEURY, additional, BERNARDES, CELENE FERNANDES, additional, FAGIONATO, FELIPE WATANABE, additional, OLIVEIRA, VITOR SANCHES DE, additional, AMARAL, FELIPE AUGUSTO APARECIDO DO, additional, CARVALHO, ANA LUÍZA ZINATO DE, additional, ARAÚJO, BEATRIZ DE SÁ GUEDES, additional, Santos, Bárbara Aparecida Costa, additional, SANTOS, GENYSON CARVALHO, additional, Saldanha, Janaína Cláudia da Silva, additional, MELO, SILVIO JOSÉ, additional, SILVA, LARISSA NASCIMENTO PACHECO, additional, ROSÁRIO, JÚLIA FELIX ALMEIDA, additional, QUADROS, SOFIA FERREIRA PENA, additional, CARVALHO, LUANA IZABELA AZEVEDO DE, additional, BIASON, GIOVANNA GUIMARÃES, additional, EVANGELISTA, MARIA ESTHER LIMA RIOS, additional, ALVES, THAYNARA CASTELO DE LIMA, additional, FUJIMOTO, VICTÓRIA CRISTINA MENDONÇA, additional, SILVA, ANA CAROLINA MENDONÇA DA, additional, PALMA, MARIA EDUARDA ROCHA SOARES, additional, VIEIRA, VITOR MARTINS, additional, SILVA, THIAGO MAGELA GOMES DA, additional, REIS, LEVI EDUARDO SOARES, additional, BASTOS, MARIANA ARAÚJO PENA, additional, BASTOS, MARIANA RODRIGUES MARINHO DE, additional, Arão, Ana Elisa Choucair Hosken, additional, OLIVEIRA, AMANDA VASCONCELOS DE, additional, COSTA, BRUNA DIULY SANTOS, additional, COSTA, HELENA FONTENELLE DE CARVALHO, additional, SOUSA, KARLA SILVIA DE, additional, COSTA, JULIANA SILVEIRA MARTINS DA, additional, FRAZÃO, VICTOR CABREIRA, additional, ALVARENGA, ALICE MARTINS, additional, DIAS, FERNANDA DAS GRAÇAS, additional, BATISTA, TAINÁ RESENDE, additional, Braga, Regiane Helena Medeiros, additional, Saltara, Alessandra, additional, Medeiros, Daniela Virginia Rios Dias de, additional, Batista, Fernanda Rubia, additional, Paula, Fernanda Roberti Gil de, additional, Demoner, Frederico Octávio Perozini, additional, Correia, Rafaela Charles, additional, VILAÇA, JHEMILY LOPES LIMA, additional, SILVA, GABRIEL SOUZA SANTOS DA, additional, SOBRINHO, WEBERTON DORÁSIO, additional, SILVA, JOÃO LUCAS ROCHA, additional, SANTOS, VINICIUS DE OLIVEIRA, additional, FERREIRA, VITÓRIA DE ARAÚJO, additional, PACHECO, LETÍCIA MESQUITA, additional, SANTOS, JOÃO VITOR MORAIS, additional, DANTAS, VERIDIANA CÉLIA BEZERRA, additional, CEMBRANEL, VINICIUS MORAIS, additional, COSTA, TIAGO ALMEIDA, additional, SOBRAL, LARISSA DANTAS, additional, FARIA, MARIANA SOARES, additional, ARAÚJO, JULIANY LINS, additional, MENEZES, VICTORIA CAROLINA LUNA, additional, SOUZA, HAYANNA CÂNDIDA CARVALHO DE, additional, AZEVEDO, MARIA REGINA DOMINGUES DE, additional, CARVALHO, NAYARA ALMEIDA, additional, TEIXEIRA, BEATRIZ NASSER, additional, ARANTES, OTÁVIO AUGUSTO LANDIM, additional, SALES, PRISCILA MAGALHÃES ESTEVES DE, additional, BORGES, RAQUEL CAMARGOS, additional, QUISTE, SARAH SOUZA, additional, OLIVEIRA, THAYENE BARBOSA DE, additional, Costa, Ana Luísa Mendes Pinheiro, additional, COSTA, ANA LUÍSA MENDES PINHEIRO, additional, RODRIGUES, MARCELA DE CASTRO BASTOS, additional, Ribeiro, Luana, additional, PEREIRA, LÍVIA VILAÇA COTA, additional, Fernandes, Thalita Baptisteli, additional, Costa, Liliana Larissa Bandeira, additional, MENDES, JOÃO FERREIRA, additional, SANTOS, MAÍSA SARGES, additional, SILVEIRA, SANDRA MARIA DO CARMO, additional, MARTINS, BEATRIZ FREITAS DE ALBUQUERQUE, additional, PAIXA, LARISSA GABRIELLE SIQUEIRA, additional, OLIVEIRA, JÉSSICA DANIELE SILVA DE, additional, VENTURA, MARIA EDUARDA MALCHER, additional, PINTO, AYLA VITÓRIA CARRÉRA DA SILVA, additional, LOBO, MIKÉY MONTEIRO, additional, ALMEIDA, JULIANA VIEIRA QUEIROZ, additional, ALMADA, BRUNO HENRIQUE GONÇALVES, additional, TORQUETTE, SARAH LOUREDO, additional, BLASSIOLI, VITOR COURI, additional, DIAS, YVES HENRIQUE FARIA, additional, ALMEIDA, FERNANDA VIEIRA QUEIROZ, additional, RODRIGUES, ELDA CRISTINA DE SOUZA RIBEIRO, additional, CASTILHO, CÉSAR TEIXEIRA, additional, Sander, Renata Cury, additional, OLIVEIRA, ANA CORINA BANDEIRA ALMEIDA RODRIGUES DE, additional, SILVA, DIOVANNA LIMA, additional, PINHEIRO, LUZIA FRANCINY DE SOUZA, additional, BITTENCOURT, MARIANA LOUZADA, additional, TANAJURA, NADYNNE PORTO MAGALHÃES, additional, AGUIAR, NATÁLIA MENDES, additional, CORRÊA, SHESLLEN MIKAELLY CRUZ, additional, MARQUES, VALERIA GOMES, additional, ARAGÃO, VITOR SANTOS, additional, SOUZA, JOANA TRENGROUSE LAIGNIER DE, additional, ZAMBOM, DANIELLE DE AQUINO, additional, SANTOS, GRACIELLE DE JESUS, additional, DÓREA, GABRIEL SILVA, additional, TELES, DANILO OLIVEIRA, additional, LACERDA, ROBERTO DOS SANTOS, additional, Souza, Letícia Karen Rodrigues de, additional, Miranda, Ana Maria Ramos, additional, Maia, Jade Menezes, additional, Desteffani, Karine Gomes Bandeira, additional, Nascimento, Andressa Schmidt do, additional, Rizziolli, Daniele Sutherland Wallauer, additional, Diniz, Lilian Coelho Heringer, additional, Lima, Cristiane dos Santos, additional, Silva, Mara Iza Alves, additional, Fecury, Priscylla Celeste Milhomem Silva, additional, SANTOS, CAROLINA TEODORO DOS, additional, NASCIMENTO, NATÁLIA SILVA, additional, BUENO, MARCELA ELISA, additional, ARAÚJO, GABRIELY TRINDADE, additional, Ferreira, Luis Marcos, additional, Sousa, Christianna Eller Silva, additional, GOMES, BRUNA LUÍSA PALHARES, additional, AMARAL, DEIVID RIBEIRO DO, additional, NASCIMENTO, DEBORAH RIBEIRO, additional, MONTEIRO, FERNANDA MENESES, additional, NASCIMENTO, IGOR RIBEIRO, additional, Souza, Thaynara N, additional, FARIAS, JOÃO VICTOR TRINDADE, additional, BARBOSA, CARLA DÉA TRINDADE, additional, Bogea, Eduarda G, additional, NASCIMENTO, RENAN MONTEIRO DO, additional, SANTOS, GIOVANA BORGES, additional, GAMA, SÁVIO FRANÇA, additional, LISBOA, THIAGO RODRIGUES, additional, SERAFIM, ISAK BATISTA MEDEIROS, additional, RAMOS, AYLA CAMPANHA, additional, RONER, MÁRCIA NUNES BANDEIRA, additional, VASCONCELLOS, ANNA FERNANDA, additional, CHARNEAU, SÉBASTIEN, additional, Silva, Maria Marta Lino de Oliveira, additional, castro, Joane Ramos Viana de, additional, Fanaia, Raphaela Tingo Narita, additional, FUJIMOTO, Camila Kazue, additional, Lopes, Franciane Silva, additional, Rêgo, Alexsandra Maria Calheiros de Almeida, additional, Silva, Graciete Mirian Pereira, additional, Takaki, Eduardo Costa, additional, Silveira, Fernanda Maria Magalhães, additional, VASCONCELOS, RAQUEL LEITE, additional, LINHARES, LIDUINA JOYCE PRADO, additional, DUARTE, ALESSANDRA CARVALHO NÓBREGA, additional, MEDEIROS, TELMA ALVES, additional, SILVA, RITA WIGNA DE SOUZA, additional, OLIVEIRA, KARINE DA SILVA, additional, VASCONCELOS, FRANCISCO HERLON PONTE DE, additional, BATISTA, CARULINA CARDOSO, additional, MARRONE, VITTORIA GIULIA DA SILVA, additional, NOIA, CHARMYLLY BISPO, additional, OLIVEIRA, ANNA VITORIA GONÇALVES SOARES DE, additional, NOGUEIRA, MARIA ISABEL TELES, additional, ARAÚJO, IOHANNA MELO DE, additional, and FREITAS, ELUANY NOGUEIRA DE, additional

Published
2021
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8. Efectividad y seguridad de los medicamentos en individuos de diferentes colores de piel y grupos étnicos con polimorfismos genéticos en el sistema enzimático del citocromo P-450: una revisión sistemática

Author

Matos, Luiz Eduardo Oliveira, Cavalcante, Rafael Ciro Marques, Brito, Gisele de Carvalho, Santos, Keila Eduarda Pereira dos, Cruz, Ivana Beatrice Mânica da, Felin, Giancarllo Danezi, Felin, Giulliano Danezi, and Unfer, Tais Cristina

Subjects
Salud Étnica, Medicina de Precisión, Estudo Farmacogenômico, Ethnic Health, Medicina de Precisão, Estudio Farmacogenómico, Farmacocinética, Medicina basada en la evidencia, Pharmacogenomic Study, Medicina baseada em evidências, Origem Étnica e Saúde, Pharmacokinetics, Precision Medicine, Evidence-based medicine
Abstract

The objective was to review, among individuals of different skin colors and ethnic groups, how the effectiveness and safety of drugs could be influenced by pharmacokinetics variations resulting from genetic polymorphisms in the cytochrome P-450 enzyme system (CYP-450). This is a systematic review study, with a descriptive and observational approach. The systematic review protocol was registered on the international platform Prospective Register of Systematic Reviews under the identification number 25581111. Data collection was performed on Medical Literature Analysis and Retrieval System Online (MedLine) through PubMed, Latin American Literature, and the Caribbean Health Sciences (LILACS), as well as the Scientific Electronic Library Online (SciELO). Six CY450 genetic polymorphisms that may affect pharmacodynamic and pharmacokinetics parameters of therapy in drug users of different ethnic and skin color was identified and described to drugs as Olanzapine, Efavirenz, and Irinotecan. However, the results found did not demonstrate the existence of clinically significant differences when evaluating the aspects of safety and effectiveness of the drugs, despite the identification of polymorphisms in the CYP450 enzyme system that influenced these parameters. The findings point to the identification of individual genotypes, without ethnic or skin color cut, to provide a better application of precision medicine, thus helping to make therapeutic decisions in clinical practice in the light Evidence-Based medicine. El objetivo fue revisar, entre individuos de diferentes colores de piel y grupos étnicos, cómo la efectividad y la seguridad de los medicamentos pueden verse influenciadas por variaciones farmacocinéticas resultantes de polimorfismos genéticos en el sistema enzimático del citocromo P-450 (CYP450). Se trata de un estudio de revisión sistemática, con enfoque descriptivo y observacional. El protocolo de revisión sistemática se registró en la plataforma internacional Prospective Register of Systematic Reviews con el número de identificación 25581. La recolección de datos se realizó en las plataformas Medical Literature Analysis and Retrieval System Online (MedLine) a través de PubMed, Latin American Literature and Caribbean in Health Sciences (LILACS), así como la Biblioteca Científica Electrónica en Línea (SciELO). Fue posible identificar y describir seis polimorfismos genéticos de CYP450 que parecen afectar los parámetros farmacocinéticos y farmacodinámicos de la farmacoterapia en usuarios de medicamentos de diferentes colores de piel y grupos étnicos para los medicamentos Olanzapina, Efavirenz e Irinotecan. Sin embargo, los resultados encontrados no demostraron la existencia de diferencias clínicamente significativas al evaluar los aspectos de seguridad y eficacia del fármaco, a pesar de la identificación de polimorfismos en el sistema enzimático CYP450 que influían en estos parámetros. Los hallazgos apuntan a la identificación de genotipos individuales, sin etnia ni color de piel, para brindar una mejor aplicación de la medicina de precisión, ayudando así a la toma de decisiones terapéuticas en la práctica clínica a la luz de la Evidencia Basada en Salud. Objetivou-se revisar, dentre indivíduos de diferentes cores de pele e grupos étnicos, como a efetividade e a segurança de medicamentos pode ser influenciada por variações farmacocinéticas resultantes de polimorfismos genéticos no sistema enzimático do citocromo P-450 (CYP450). Trata-se de um estudo do tipo revisão sistemática, com abordagem descritiva e observacional. O protocolo da revisão sistemática foi submetido a registro na plataforma internacional Prospective Register of Systematic Reviews sob o número de identificação 25581. A coleta de dados foi realizada nas plataformas Medical Literature Analysis and Retrieval System Online (MedLine) através da PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), bem como na Scientific Eletronic Library Online (SciELO). Foi possível identificar e descrever seis polimorfismos genéticos do CYP450 que parecem afetar os parâmetros farmacocinéticos e farmacodinâmicos da farmacoterapia em usuários de medicamentos de diferentes cores de pele e grupos étnicos para os medicamentos Olanzapina, Efavirenz e Irinotecano. No entanto, os resultados encontrados não demonstraram a existência de diferenças clinicamente significativas quando avaliados os aspectos de segurança e efetividade de medicamento, apesar de serem identificados os polimorfismos no sistema enzimático do CYP450 que influenciavam nesses parâmetros. Os achados apontam para a identificação dos genótipos individuais, sem recorte étnico ou de cor da pele, a fim de propiciar uma melhor aplicação da medicina de precisão, auxiliando, assim, na tomada de decisões terapêuticas na prática clínica sob à luz da Saúde Baseada em Evidências.

Published
2022

9. Dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in the Northeast region of Brazil

Author

de Souza Araújo, Adriano Antunes, primary, Quintans-Júnior, Lucindo José, additional, Heimfarth, Luana, additional, Schimieguel, Dulce Marta, additional, Corrêa, Cristiane Bani, additional, de Moura, Tatiana Rodrigues, additional, Cavalcante, Rafael Ciro Marques, additional, Grespan, Renata, additional, de Souza Siqueira Quintans, Jullyana, additional, dos Santos, Danillo Menezes, additional, da Silva, Danilo Nobre, additional, de Oliveira, Yrna Lorena Matos, additional, de Franca, Mariana Nobre Farias, additional, da Conceição Silva, Marcílio, additional, de Sá, Darla Lorena Freitas, additional, de Carvalho, Fernanda Oliveira, additional, de Souza, Mércia Feitosa, additional, de Oliveira Góes, Marco Aurélio, additional, Santos, Victor Santana, additional, and Martins-Filho, Paulo Ricardo, additional

Published
2022
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10. Efetividade e segurança de medicamentos em indivíduos de diferentes cores de pele e grupos étnicos com polimorfismos genéticos no sistema enzimático do citocromo P-450: uma revisão sistemática

Author

Matos, Luiz Eduardo Oliveira, primary, Cavalcante, Rafael Ciro Marques, additional, Brito, Gisele de Carvalho, additional, Santos, Keila Eduarda Pereira dos, additional, Cruz, Ivana Beatrice Mânica da, additional, Felin, Giancarllo Danezi, additional, Felin, Giulliano Danezi, additional, and Unfer, Tais Cristina, additional

Published
2022
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11. Dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in the Northeast region of Brazil.

Author

de Souza Araújo, Adriano Antunes, Quintans-Júnior, Lucindo José, Heimfarth, Luana, Schimieguel, Dulce Marta, Corrêa, Cristiane Bani, de Moura, Tatiana Rodrigues, Cavalcante, Rafael Ciro Marques, Grespan, Renata, de Souza Siqueira Quintans, Jullyana, dos Santos, Danillo Menezes, da Silva, Danilo Nobre, de Oliveira, Yrna Lorena Matos, de Franca, Mariana Nobre Farias, da Conceição Silva, Marcílio, de Sá, Darla Lorena Freitas, de Carvalho, Fernanda Oliveira, de Souza, Mércia Feitosa, de Oliveira Góes, Marco Aurélio, Santos, Victor Santana, and Martins-Filho, Paulo Ricardo

Subjects
COVID-19 pandemic, SEROPREVALENCE, SARS-CoV-2, COVID-19, METROPOLITAN areas, ANTIBODY titer
Abstract

In this household-based seroepidemiological survey, we analyzed the dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in Sergipe State, Northeast Brazil, the poorest region of the country. A total of 16,547 individuals were tested using a rapid IgM−IgG antibody test and fluorescence immunoassay (FIA). Seroprevalence rates were presented according to age, sex, and geographic region. A comparative analysis was performed between the results obtained in July 2020 (peak of the first wave), August – November 2020 (end of the first wave), and February – March 2021 (beginning of the second wave). Seroprevalence rates in the three phases were estimated at 9.3% (95% CI 8.5–10.1), 12.0% (95% CI 11.2–12.9) and 15.4% (95% CI 14.5–16.4). At the end of the first wave, there was a rise in seroprevalence in the countryside (p < 0.001). At the beginning of the second wave, we found an increase in seroprevalence among women (p < 0.001), adults aged 20 to 59 years (p < 0.001), and the elderly (p < 0.001). In this phase, we found an increase in estimates both in metropolitan areas and in the countryside (p < 0.001). This study showed an increase in SARS-CoV-2 seroprevalence over the first year of the pandemic, with approximately one in six people having anti-SARS-CoV-2 antibodies at the beginning of the second wave of COVID-19. Furthermore, our results suggest a rapid spread of COVID-19 from metropolitan areas to the countryside during the first months of the pandemic. [ABSTRACT FROM AUTHOR]

Published
2023
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12. OTIMIZAÇÃO E VALIDAÇÃO DE MÉTODO ENZIMÁTICO SEMIQUANTITATIVO SIMPLES E DE BAIXO CUSTO PARA A BUSCA DE INIBIDORES DE CISTEINO PROTEASES

Author

Andrade, Ana Karolina de Souza, Santos, Luana Andrade, Menezes, Edisleide Silva, Cavalcante, Rafael Ciro Marques, and Silva, James Almada da

Subjects
papain, natural products, enzyme inhibitors, food and beverages, agar diffusion, casein
Abstract

Cysteine proteases are an important class of enzymes involved in several essential biological processes. For this reason, these enzymes are important therapeutic targets, and therefore can be used in enzymatic assays for the search of hits. The most widely used methods in the search of enzyme inhibitors are spectrophotometric, however they have relatively high operational costs. For this reason, simpler, and cheaper methods can be useful in the search for enzyme inhibitors. In this work, a simple and low-cost semi-quantitative method was optimized and validated using papain and skimmed powdered milk (casein) as a substrate. The ideal condition for the method was the one that used powdered milk, 0.250%, papain solution, 9.4 mg mL-1 and incubation time, 18 h. The method validation was performed using the inhibitor E64 and herb extracts, in different concentrations. After carrying out the experiments and statistical analyses, a high reproducibility can be observed, with relative standard deviations below 2.1%. Plant extracts were used to test the method and the results indicated that these extracts are promising for the search of cysteine protease inhibitors. The method developed here has simplicity and reproducibility and has great application, as preliminary study, in the search for inhibitors of cysteine proteases.

Published
2021

13. Description and Interrelationship Analysis of the Phenotypic and Genotypic Characteristics of MSSA and MRSA Strains Isolated From Healthcare Workers in North-eastern Brazil

Author

de Oliveira, Maraiza Alves, primary, Andrade, Yasmin Monara Ferreira Sousa, additional, Souza, Alisson da Costa, additional, Silva, Icaro Bonyek Santos da, additional, Campos, Guilherme Barreto, additional, Marques, Lucas Miranda, additional, Doria, Grace Anne Azevedo, additional, and Cavalcante, Rafael Ciro Marques, additional

Published
2021
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14. Seroprevalence of SARS-CoV-2 antibodies in low-income university students

Author

Araújo, Adriano Antunes De Souza, Quintans-Júnior, Lucindo José, Schimieguel, Dulce Marta, Corrêa, Cristiane Bani, De Moura, Tatiana Rodrigues, Cavalcante, Rafael Ciro Marques, Grespan, Renata, Cerqueira-Meneses, Daniele De Vasconcelos, Barreto-Alves, José Antônio, and Martins-Filho, Paulo Ricardo

Subjects
poverty, seroepidemiologic studies, COVID-19, Letter to the Editor, Brazil, universities
Abstract

EXCLI Journal; 20:Doc276; ISSN 1611-2156

Published
2021

15. Mapping the technological landscape of SARS, MERS, and SARS-CoV-2 vaccines

Author

Nascimento Júnior, José Adão Carvalho, primary, Santos, Anamaria Mendonça, additional, Cavalcante, Rafael Ciro Marques, additional, Quintans-Júnior, Lucindo José, additional, Walker, Cristiani Isabel Banderó, additional, Borges, Lysandro Pinto, additional, Frank, Luiza Abrahão, additional, and Serafini, Mairim Russo, additional

Published
2021
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16. Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study

Author

de Souza Araújo, Adriano Antunes, primary, Quintans-Júnior, Lucindo José, additional, Heimfarth, Luana, additional, Schimieguel, Dulce Marta, additional, Corrêa, Cristiane Bani, additional, de Moura, Tatiana Rodrigues, additional, Cavalcante, Rafael Ciro Marques, additional, Rodrigues Bomfim, Rangel, additional, Grespan, Renata, additional, Santana Rodrigues, Lorranny, additional, dos Santos, Danillo Menezes, additional, de Sá Resende, Ayane, additional, de Lima Silva, Nathanielly, additional, da Silva Santos, Anna Clara Ramos, additional, Dantas Araújo, Jéssica Maria, additional, de Souza, Mércia Feitosa, additional, de Oliveira Góes, Marco Aurélio, additional, Santana Santos, Victor, additional, and Martins-Filho, Paulo Ricardo, additional

Published
2021
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22. Bacillus subtilis Spores as Vaccine Adjuvants: Further Insights into the Mechanisms of Action.

Author

de Souza, Renata Damásio, Batista, Milene Tavares, Luiz, Wilson Barros, Cavalcante, Rafael Ciro Marques, Amorim, Jaime Henrique, Bizerra, Raíza Sales Pereira, Martins, Eduardo Gimenes, and de Souza Ferreira, Luís Carlos

Subjects
BIOTECHNOLOGY, BACILLUS subtilis, BACTERIAL spores, BACTERIAL vaccines, DRUG administration, IMMUNIZATION
Abstract

Bacillus subtilis spores have received growing attention regarding potential biotechnological applications, including the use as probiotics and in vaccine formulations. B. subtilis spores have also been shown to behave as particulate vaccine adjuvants, promoting the increase of antibody responses after co-administration with antigens either admixed or adsorbed on the spore surface. In this study, we further evaluated the immune modulatory properties of B. subtilis spores using a recombinant HIV gag p24 protein as a model antigen. The adjuvant effects of B. subtilis spores were not affected by the genetic background of the mouse lineage and did not induce significant inflammatory or deleterious effects after parenteral administration. Our results demonstrated that co-administration, but not adsorption to the spore surface, enhanced the immunogenicity of that target antigen after subcutaneous administration to BALB/c and C57BL/6 mice. Spores promoted activation of antigen presenting cells as demonstrated by the upregulation of MHC and CD40 molecules and enhanced secretion of pro-inflammatory cytokines by murine dendritic cells. In addition, in vivo studies indicated a direct role of the innate immunity on the immunomodulatory properties of B. subtilis spores, as demonstrated by the lack of adjuvant effects on MyD88 and TLR2 knockout mouse strains. [ABSTRACT FROM AUTHOR]

Published
2014
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23. Otimização da extração de sesquiterpenos de Zingiber officinale roscoe e avaliação do seu potencial biológico frente a fatores de virulência de bactérias

Author

Santos, Jussara Oliveira dos, Silva, James Almada da, and Cavalcante, Rafael Ciro Marques

Subjects
Optimization, QUIMICA [CIENCIAS EXATAS E DA TERRA], Agentes anti-infecciosos, Hidrofobicidade, Biofilm, Hydrophobicity, Gengibre, Biofilme, Química, Ginger, Antimicrobiano, Protease, Antimicrobial, Enzimas proteolíticas
Abstract

Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq Ginger (Zingiber officinale Roscoe) is a medicinal plant known for its anti-inflammatory, antitumoral, antioxidant and antimicrobial properties. The objective of this study was to optimize the extraction of sesquiterpenes (α-curcumene, α-zingiberene, α-farnesene, β-sesquifelandrene and β-bisabolene), to evaluate their antimicrobial and antibiotic potential against Staphylococcus aureus, Streptococcus mutans, S. agalactiae, Escherichia coli and Pseudomonas aeruginosa, in addition to their antiproteic activity. Analyzes of the extracted compounds were performed by GC-MS. Antimicrobial and biofilm formation assays were performed by the 96 well plate microdilution technique. In addition to assessing biofilm inhibition, the hydrophobicity index was also determined as an indirect way of assessing the ability of microorganisms to adhere to host tissues and abiotic surfaces. The best conditions for obtaining the sesquiterpene-enriched fraction (SEF) were: extraction time: 4 min, plant / solvent ratio: 1:20 (m / v) and microwave power: 400 W. The SEF presented a MIC of 2000 μg / mL compared to S. mutans and was ineffective in inhibiting the growth of other bacteria. Nevertheless, SEF (250 μg / mL) inhibited the biofilm formation of S. aureus, S. agalactiae and E. coli by 50%, 80% and 80%, respectively. In addition, and E. coli bacteria by 61.86%, 73.44% and 49.10%, respectively. FES (500 μg / mL) was able to reduce papain enzymatic activity by 71.5%, with an IC50 of 386.8 μg / mL. The results showed that SEF had potential to combat the production of bacterial biofilms. Thus, these substances are good candidates for drug prototypes used to treat infections caused by multi-resistant bacteria. To our knowledge, this is the first time that the SEF antimicrobial and antibiofilm activity has been studied. O gengibre (Zingiber officinale Roscoe) é uma planta medicinal conhecida por suas propriedades anti-inflamatórias, antitumorais, antioxidantes e antimicrobianas. O objetivo deste trabalho foi otimizar a extração de sesquiterpenos (α-curcumeno, α-zingibereno, α-farneseno, β-sesquifelandreno e β-bisaboleno), avaliar seu potencial antimicrobiano e antibiofilme contra Staphylococcus aureus, Streptococcus mutans, S. agalactiae, Escherichia coli e Pseudomonas aeruginosa, além da sua atividade antiproteásica. As análises dos compostos extraídos foram realizadas por CG-ES. Os ensaios antimicrobianos e formação de biofilmes foram realizados pela técnica de microdiluição em placas de 96 poços. Além de avaliar a inibição do biofilme, o índice de hidrofobicidade também foi determinado como uma forma indireta de avaliar a capacidade de adesão dos micro-organismos aos tecidos hospedeiros e superfícies abióticas. As melhores condições para obtenção da fração enriquecida em sesquiterpenos (FES) foram: tempo de extração: 4 min, razão planta/solvente: 1:20 (m/v) e potência de micro-ondas: 400 W. A FES apresentou CIM de 2000 μg/mL frente a S. mutans e foi inefetivo na inibição do crescimento das outras bactérias. Apesar disso a FES (250 g/mL) inibiu a formação de biofilme de S. aureus, S. agalactiae E. coli em 50%, 80% e 80%, respectivamente. Ademais, a FES (250 g/mL) reduziu o índice de hidrofobicidade das bactérias S. aureus, S. agalactiae e E. coli em 61,86%, 73,44% e 49,10%, respectivamente. A FES (500 μg/mL) foi capaz de reduzir em 71,5% a atividade enzimática da papaína, apresentando IC50 386,8 μg/mL. Os resultados mostraram que a FES apresentou potencial no combate à produção de biofilmes bacterianos. Desse modo, essas substâncias representam-se como bons candidatos a protótipos de medicamentos utilizados no tratamento de infecções causadas por bactérias multirresistentes. Até onde sabemos, esta é a primeira vez que a atividade antimicrobiana e antibiofilme da FES foi estudada. São Cristóvão, SE

Published
2019

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