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5. Protocolisation, utilisation et développement des médicaments anticancéreux dans le cadre de la mise en place de la T2A

Author

Aoustin, M., Atlani, C., Bassompierre, F., Benamouzig, R., Bonavita, M.-J., Borella, L., Calvo, F., Caulin, C., Cellier, D., Dahan, M., Daura, V., De Beels, F., De Vernejoul, N., Diebolt, V., Dumarcet, N., Durand Zaleski, I., Fery Lemonnier, E., Genève, J., Giri, I., Golinelli, D., Labreveux, C., Latour, J.-F., Maraninchi, D., Meresse, V., Mignot, L., Morlet, D., Pépin, S., Ravaud, P., Riché, C., Rouleau, A., Tilleul, P., Viens, P., Mathieu-Boué, Anne, Demolis, Pierre, and Bergmann, Jean-François

Published
2006
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6. Protocolisation, Use and Development of Anti-Cancer Drugs in the Context of T2A (Case-Mix Based Payment System) Set-Up

Author

Aoustin, M., Atlani, C., Bassompierre, F., Benamouzig, R., Bonavita, M.-J., Borella, L., Calvo, F., Caulin, C., Cellier, D., Dahan, M., Daura, V., De Beels, F., De Vernejoul, N., Diebolt, V., Dumarcet, N., Durand Zaleski, I., Fery Lemonnier, E., Genève, J., Giri, I., Golinelli, D., Labreveux, C., Latour, J.-F., Maraninchi, D., Meresse, V., Mignot, L., Morlet, D., Pépin, S., Ravaud, P., Riché, C., Rouleau, A., Tilleul, P., Viens, P., Mathieu-Boué, Anne, Demolis, Pierre, and Bergmann, Jean-François

Published
2006
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8. Modélisation et essais cliniques en pédiatrie

Author

Armengaud, D., Bost, I., Carpentier, A., Caulin, C., Crépin, C., Fuseau, E.-M., Gerberg, M., Grosskopf, C., Gueyffier, F., Labouret, N. Hoog, Jacqmin, P., Laveille, C., Le Gellec, C., Marquet, P., Ouslimani, A., Pons, G., Simeoni, U., Simon, N., Tranchand, B., Treluyer, J.-M., Jacqmin, Philippe, Labouret, Nathalie, and Gueyffier, François

Published
2005
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9. Modelling and Clinical Trials in Paediatrics

Author

Armengaud, D., Bost, I., Carpentier, A., Caulin, C., Crépin, C., Fuseau, E.-M., Gerberg, M., Grosskopf, C., Gueyffier, F., Labouret, N. Hoog, Jacqmin, P., Laveille, C., Le Gellec, C., Marquet, P., Ouslimani, A., Pons, G., Simeoni, U., Simon, N., Tranchand, B., Treluyer, J.-M., Jacqmin, Philippe, Labouret, Nathalie, and Gueyffier, François

Published
2005
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14. Adaptation of the Clinical Trials Directive

Author

Berger, F., Bertoye, P.-H., Brion, N., Buntix, A., Caplain, H., Caulin, C., Courcier-Duplantier, S., Daurat, V., Demarez, J.-P., Diquet, B., Echemann, M., Funck-Brentano, C., Lamarque, V., Laurent, S., Libersa, C., Marey, C., Moore, N., Patat, A., Pinquier, J.-L., Reynier, J.-C., Sawaya, A., Sibenaler, C., Simon, N., Tremblay, D., Vella, P., Warot, D., Bélorgey, Chantal, Plétan, Yannick, and Goehrs, Jean-Marie

Published
2004
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15. Transposition de la Directive Essais Cliniques

Author

Berger, F., Bertoye, P.-H., Brion, N., Buntix, A., Caplain, H., Caulin, C., Courcier-Duplantier, S., Daurat, V., Demarez, J.-P., Diquet, B., Echemann, M., Funck-Brentano, C., Lamarque, V., Laurent, S., Libersa, C., Marey, C., Moore, N., Patat, A., Pinquier, J.-L., Reynier, J.-C., Sawaya, A., Sibenaler, C., Simon, N., Tremblay, D., Vella, P., Warot, D., Bélorgey, Chantal, Plétan, Yannick, and Goehrs, Jean-Marie

Published
2004
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16. Infections I

Author

Schneider, F., Lutun, Ph., Runge, I., Launoy, A., Hasselmann, M., Tempé, J. D., Sipria, A., Talvik, R., Mancebo, J., Domingo, P., Coll, P., Net, A., Ibarz, M., Sancho, J., Sitges-Serra, A., Woittiez, A. J. J., Kaan, J., Goldhoorn, P., Almirall, J., Mesalles, E., Klanturg, J., Armengol, S., Agudo, A., González, C. A., Tomasa, A., Santré, C., Leroy, O., Beuscart, C., Guéry, B., Georges, H., Beaucaire, G., Salord, F., Grando, J., Verges, M., Desgaches, C., Chacornac, R., Maravi, E., García-Jalón, J., Sánchez-Nicolay, I., Saenz, JJ., Maynar, J., Fonseca, F., Jiménez, I., Eami, V., Mencherini, S., Barzaghi, N., Marone, P., Gallini, G. Sala, Olivei, M., Eraschi, A., Nouira, S., Elatrous, S., Abroug, F., Jaafoura, M., Bouchoucha, S., Thabet, H., Rauss, A., Brun-Buisson, C., Sproat, Lu, Inglis, T. J. J., Elkharrat, D., Mauboussin, Ph., Bodossian, P., Porché, M., Pénicaud, M., Le Corre, A., Caulin, C., Leleu, G., Le Junter, J., Villiers, S., Garrouste, M. T., Rabbat, A., Schremmer, B., Le Gall, J. R., Morinet, F., Schlemmer, B., Ribeiro C., Moreira J., Costa D., Costa M., Pina E., Salgado M. J., Gasanovic-Popovic, D., Ratkovic, R., Bura-Nikolic, G., Stosic, M., Kaludjerovic, M., Grujicic, D., Santré, Ch., Simon, M., Konrad, F., Wagner, R., Kilian, J., Georgieff, M., Zhongmin, Hou, Huping, Zhou, Sarmiento, X., Tonig, R., Hosallos, E., Torres, A., Soler, H., Mills, J., Tomasal, A., León, M. A., Ayuso, A., Díaz, R., Robusté, J., Soria, G., Torres, C., Nolla, M., Jimenez, M. J., Lizasoein, M., Suarez, T., Sanchez-Izquierdo, J. A., Martinez, A., Arribas, P., Bermejo, S., Alted, E., Santré, Ch., Fourrier, F., Gregorakos, L., Katsanos, C., Malessios, V., Nicolopoulos, J., Tsokou, J., Nicolaou, Ch., Kountouri, M., Velasco, P., Moreno, J. A., Torrabadella, P., Castellà, E., Gómez, M. C., Condom, J. M., Esquirol, X., Domingo, Ch., Pérez-Piteira, J., Tomás, R., Reingardiené, D., Ambrazevićiené, N., and Working group on infectious diseases. Espanish Society of Intensive Care Medicine

Published
1992
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24. The therapeutic guidelines database, an original new tool

Author

Caulin, C., Autret-Leca, E., Baumelou, A., Trémolières, F., German, C., Darmoni, Stéfan, Thirion, Benoit, Forget, Jean-François, and Lecroq, Thierry

Subjects
[INFO.INFO-DS] Computer Science [cs]/Data Structures and Algorithms [cs.DS]
Published
2007

28. [Fatal fulminant acute amebic colitis in metropolitan France]

Author

Mahé I, Delahaye V, Caulin C, and Jean-Francois Bergmann

Subjects
Diagnosis, Differential, Male, Fatal Outcome, Urban Population, Colon, Risk Factors, Biopsy, Dysentery, Amebic, Humans, Colonoscopy, France, Aged
Abstract

Emergency care is required for patients presenting dysentery and fever.A 65-year old patient living in metropolitan France was hospitalized for watery diarrhea that had progressively worsened over the last month. Rectal bleeding was also noted. Serology tests at admission, together with parasitology examination of the fecal matter and colonoscopy led to the diagnosis of intestinal amebiasis a few hours before the patient's rapid death. Serology was positive for amebas and the diagnosis was confirmed by pathology examination of the colonoscopy biopsies.The diagnosis of amebiasis should be entertained even in Europe when there is no history of travel to endemic areas in patients who develop suggestive manifestations. Identification of amebas in the fecal matter and serology tests provide certain diagnosis. Clinicians should recall that rapidly fatal outcome is not uncommon in severe forms. Emergency care is mandatory.

Published
2001

31. A randomised clinical trial of the effect of informed consent on the analgesic activity of placebo and naproxen in cancer pain

Author

Jean-Francois Bergmann, Chassany O, Gandiol J, Deblois P, Ja, Kanis, Jm, Segrestaa, Caulin C, and Dahan R

Subjects
Adult, Aged, 80 and over, Male, Analgesics, Cross-Over Studies, Informed Consent, Research Subjects, Pain, Disclosure, Middle Aged, Placebo Effect, Therapeutic Human Experimentation, Placebos, Naproxen, Double-Blind Method, Neoplasms, Humans, Female, Prospective Studies, Aged, Pain Measurement
Abstract

To determine whether informed consent in a therapeutic trial modifies the analgesic effect of naproxen and placebo, we conducted a prospective, randomised, single dose, placebo-controlled trial. Patients were randomly selected to receive or not information concerning the study. All patients included were then given a single dose of naproxen and placebo according to a crossover, double-blind design. Forty-nine patients with mild or moderate cancer pain which did not need narcotic analgesics entered the study. Twenty-five received both treatments without any information and constituted the uninformed group. Twenty-four had a complete information about the trial; six refused to participate. The 18 others constituted the informed-consent group. Visual analogue scales of pain before and 30, 60, 120 and 180 min after the intake of naproxen and placebo were recorded. As an analgesic, naproxen was more effective than placebo in both groups of patients (p = 0.001). For naproxen as well as for placebo, the analgesic effect was better in the informed-consent group compared to the uninformed group (p = 0.012). The difference in therapeutic activity between naproxen and placebo was moderately higher in the uninformed patients (p = 0.08). We concluded that, in contrast with parallel studies, giving information in a crossover, placebo-controlled trial may increase the apparent efficacy of both the tested agent and the placebo, and decrease the perceived difference the two.

Published
1994

33. [Protective effect of misoprostol on the changes of transgastric potential difference induced by aspirin in man]

Author

Jean-Francois Bergmann, Simoneau G, Naudin R, Caulin C, and Jm, Segrestaa

Subjects
Adult, Male, Aspirin, Double-Blind Method, Gastric Mucosa, Humans, Female, Alprostadil, Anti-Ulcer Agents, Misoprostol, Membrane Potentials
Abstract

The measurement of transgastric electric potential difference (DDP) is an easy and reproducible method for evaluation of the gastrotoxicity of aspirin. This randomised crossover placebo-controlled trial in 12 healthy volunteers involved study of the protective effect of misoprostol (Cytotec) against the fall in DDP induced by a gram of aspirin. One day of treatment with misoprostol 200 micrograms morning and evening led to a statistically lower fall in DDP than with the placebo: area under the curve 130 +/- 315 mV.min cf. 589 +/- 465 mV.min (p = 0.012), maximum variation 11.4 +/- 11.3 mV cf. 24.9 +/- 13.2 mV (p = 0.04). This result independent of the antisecretory action of the compound, confirms the protective effect of this prostaglandin analogue against the gastric damage caused by aspirin.

Published
1991

34. Effect of psychological stress on gastric potential difference in man

Author

Jean-Francois Bergmann, Caulin C, Genève J, Simoneau G, and Jm, Segrestaa

Subjects
Adult, Male, Gastric Juice, Heart Rate, Respiration, Stomach, Humans, Blood Pressure, Female, Noise, Stress, Psychological, Membrane Potentials
Abstract

This study investigated the effect of three different mental stress tests on gastric transmucosal electric potential difference (GPD). GPD measurement was carried out in six healthy volunteers using the agar-KCl bridges method during dichotomous listening, the ringing of a telephone and 90 dB noise. Cardiac, pulmonary and psychological responses to stress were evaluated at the same time. During the stress period, two of the subjects had no change in GPD as well as no extragastric modification due to the stressor. The four other volunteers had a significant stress-induced fall in GPD (12.5 + 5.6 mV) with a simultaneous acceleration of heart and respiration rates and an increase in systolic blood pressure and anxiety feelings which were evaluated on a visual scale. Such mental stress, possibly mediated by autonomous nervous system, may cause some gastric mucosa changes inducing the retrodiffusion of H+ ions and a fall in GPD. This model could be useful in therapeutic research into the prevention and treatment of stress-induced gastric lesions.

Published
1991

35. Protocolisation, utilisation et développement des médicaments anticancéreux dans le cadre de la mise en place de la T2A

Author

Mathieu-Boué, Anne, primary, Demolis, Pierre, additional, Bergmann, Jean-François, additional, Aoustin, M., additional, Atlani, C., additional, Bassompierre, F., additional, Benamouzig, R., additional, Bonavita, M.-J., additional, Borella, L., additional, Calvo, F., additional, Caulin, C., additional, Cellier, D., additional, Dahan, M., additional, Daura, V., additional, De Beels, F., additional, De Vernejoul, N., additional, Diebolt, V., additional, Dumarcet, N., additional, Durand Zaleski, I., additional, Fery Lemonnier, E., additional, Genève, J., additional, Giri, I., additional, Golinelli, D., additional, Labreveux, C., additional, Latour, J.-F., additional, Maraninchi, D., additional, Meresse, V., additional, Mignot, L., additional, Morlet, D., additional, Pépin, S., additional, Ravaud, P., additional, Riché, C., additional, Rouleau, A., additional, Tilleul, P., additional, and Viens, P., additional

Published
2006
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36. Protocolisation, Use and Development of Anti-Cancer Drugs in the Context of T2A (Case-Mix Based Payment System) Set-Up

Author

Mathieu-Boué, Anne, primary, Demolis, Pierre, additional, Bergmann, Jean-François, additional, Aoustin, M., additional, Atlani, C., additional, Bassompierre, F., additional, Benamouzig, R., additional, Bonavita, M.-J., additional, Borella, L., additional, Calvo, F., additional, Caulin, C., additional, Cellier, D., additional, Dahan, M., additional, Daura, V., additional, De Beels, F., additional, De Vernejoul, N., additional, Diebolt, V., additional, Dumarcet, N., additional, Durand Zaleski, I., additional, Fery Lemonnier, E., additional, Genève, J., additional, Giri, I., additional, Golinelli, D., additional, Labreveux, C., additional, Latour, J.-F., additional, Maraninchi, D., additional, Meresse, V., additional, Mignot, L., additional, Morlet, D., additional, Pépin, S., additional, Ravaud, P., additional, Riché, C., additional, Rouleau, A., additional, Tilleul, P., additional, and Viens, P., additional

Published
2006
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37. Modelling and Clinical Trials in Paediatrics

Author

Jacqmin, Philippe, primary, Labouret, Nathalie, additional, Gueyffier, François, additional, Armengaud, D., additional, Bost, I., additional, Carpentier, A., additional, Caulin, C., additional, Crépin, C., additional, Fuseau, E.-M., additional, Gerberg, M., additional, Grosskopf, C., additional, Gueyffier, F., additional, Labouret, N. Hoog, additional, Jacqmin, P., additional, Laveille, C., additional, Le Gellec, C., additional, Marquet, P., additional, Ouslimani, A., additional, Pons, G., additional, Simeoni, U., additional, Simon, N., additional, Tranchand, B., additional, and Treluyer, J.-M., additional

Published
2005
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38. Modélisation et essais cliniques en pédiatrie

Author

Jacqmin, Philippe, primary, Labouret, Nathalie, additional, Gueyffier, François, additional, Armengaud, D., additional, Bost, I., additional, Carpentier, A., additional, Caulin, C., additional, Crépin, C., additional, Fuseau, E.-M., additional, Gerberg, M., additional, Grosskopf, C., additional, Gueyffier, F., additional, Labouret, N. Hoog, additional, Jacqmin, P., additional, Laveille, C., additional, Le Gellec, C., additional, Marquet, P., additional, Ouslimani, A., additional, Pons, G., additional, Simeoni, U., additional, Simon, N., additional, Tranchand, B., additional, and Treluyer, J.-M., additional

Published
2005
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40. Adaptation of the Clinical Trials Directive

Author

Bélorgey, Chantal, primary, Plétan, Yannick, additional, Goehrs, Jean-Marie, additional, Berger, F., additional, Bertoye, P.-H., additional, Brion, N., additional, Buntix, A., additional, Caplain, H., additional, Caulin, C., additional, Courcier-Duplantier, S., additional, Daurat, V., additional, Demarez, J.-P., additional, Diquet, B., additional, Echemann, M., additional, Funck-Brentano, C., additional, Lamarque, V., additional, Laurent, S., additional, Libersa, C., additional, Marey, C., additional, Moore, N., additional, Patat, A., additional, Pinquier, J.-L., additional, Reynier, J.-C., additional, Sawaya, A., additional, Sibenaler, C., additional, Simon, N., additional, Tremblay, D., additional, Vella, P., additional, and Warot, D., additional

Published
2004
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41. Transposition de la Directive Essais Cliniques

Author

Bélorgey, Chantal, primary, Plétan, Yannick, additional, Goehrs, Jean-Marie, additional, Berger, F., additional, Bertoye, P.-H., additional, Brion, N., additional, Buntix, A., additional, Caplain, H., additional, Caulin, C., additional, Courcier-Duplantier, S., additional, Daurat, V., additional, Demarez, J.-P., additional, Diquet, B., additional, Echemann, M., additional, Funck-Brentano, C., additional, Lamarque, V., additional, Laurent, S., additional, Libersa, C., additional, Marey, C., additional, Moore, N., additional, Patat, A., additional, Pinquier, J.-L., additional, Reynier, J.-C., additional, Sawaya, A., additional, Sibenaler, C., additional, Simon, N., additional, Tremblay, D., additional, Vella, P., additional, and Warot, D., additional

Published
2004
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