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3. Standards for practical intravenous rapid drug desensitization & delabeling: A WAO committee statement

Author

Ali, F. Runa, Angel-Pereira, Denisse, Banerji, Aleena, Berges-Gimeno, Maria Pilar, Bernal-Rubio, Lorena, Brockow, Knut, Cardona Villa, Ricardo, Castells, Mariana C., Caubet, Jean-Christoph, Chang, Yoon-Seok, Ensina, Luis Felipe, Chikhladze, Manana, Chiriac, Anca Mirela, Chung, Weng-Hung, Ebisawa, Motohiro, Fernandes, Bryan, Garvey, Lene Heise, Gomez, Maximiliano, Gomez Vera, Javier, Gonzalez Diaz, Sandra, Hong, David I., Ivancevich, Juan Carlos, Kang, Hye-Ryun, Khan, David A., Kuruvilla, Merin, Larco Sousa, Jose Ignacio, Latour-Staffeld, Patricia, Liu, Anne Y., Macy, Eric, Malling, Hans Jorgen, Maspero, Jorge, May, Sara M., Mayorga, Cristobalina, Park, Miguel A., Peter, Jonathan, Picard, Matthieu, Rodriguez-Bouza, Tito, Romano, Antonino, Sanchez-Borges, Mario, Tanno, Luciana Kase, Torres, Maria Jose, Ureña-Tavera, Alicia, Valluzzi, Rocco L., Volcheck, Gerald W., Yamaguchi, Masao, Alvarez-Cuesta, Emilio, Madrigal-Burgaleta, Ricardo, Broyles, Ana D., Cuesta-Herranz, Javier, Guzman-Melendez, Maria Antonieta, Maciag, Michelle C., Phillips, Elizabeth J., Trubiano, Jason A., Wong, Johnson T., and Ansotegui, Ignacio

Published
2022
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7. Managing food protein–induced enterocolitis syndrome during the coronavirus disease 2019 pandemic: Expert recommendations

Author

Arasi, Stefania, Barad, Ashis V., Bingemann, Theresa, Brown-Whitehorn, Terri, Durban, Raquel, Green, Todd, Konstantinou, George, Leonard, Stephanie, Lightdale, Jennifer, Muraro, Antonella, Nomura, Ichiro, Spergel, Jonathan, Venter, Carina, Nowak-Wegrzyn, Anna, Cianferoni, Antonella, Bird, J.A., Fiocchi, Alessandro, and Caubet, Jean Christoph

Published
2020
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13. EAACI/ENDA position paper on drug provocation testing

Author

Barbaud, Annick, Garvey, Lene Heise, Torres, Maria, Laguna, Jose Julio, Arcolaci, Alessandra, Bonadonna, Patrizia, Scherer Hofmeier, Kathrin, Chiriac, Anca Mirela, Cernadas, Josefina, Caubet, Jean Christoph, Brockow, Knut, Barbaud, Annick, Garvey, Lene Heise, Torres, Maria, Laguna, Jose Julio, Arcolaci, Alessandra, Bonadonna, Patrizia, Scherer Hofmeier, Kathrin, Chiriac, Anca Mirela, Cernadas, Josefina, Caubet, Jean Christoph, and Brockow, Knut

Abstract

In drug hypersensitivity, drug provocation testing (DPT), also called drug challenge, is the gold standard for investigation. In recent years, risk stratification has become an important tool for adjusting the diagnostic strategy to the perceived risk, whilst still maintaining a high level of safety for the patient. Skin tests are recommended before DPT but may be omitted in low-risk patients. The task force suggests a strict definition of such low-risk patients in children and adults. Based on experience and evidence from studies of allergy to beta-lactam antibiotics, an algorithm on how to adjust DPT to the risk, and when to omit skin tests before DPT, is presented. For other antibiotics, non-steroidal anti-inflammatory drugs and other drugs, skin tests are poorly validated and DPT is frequently necessary. We recommend performing DPT with chemotherapeutics and biologicals to avoid unnecessary desensitization procedures and DPT with skin tests negative contrast media. We suggest DPT with anesthetics only in highly specialized centers. Specifics of DPT to proton pump inhibitors, anticonvulsants and corticosteroids are discussed. This position paper provides general recommendations and guidance on optimizing use of DPT, whilst balancing benefits with patient safety and optimizing the use of the limited available resources., In drug hypersensitivity, drug provocation testing (DPT), also called drug challenge, is the gold standard for investigation. In recent years, risk stratification has become an important tool for adjusting the diagnostic strategy to the perceived risk, whilst still maintaining a high level of safety for the patient. Skin tests are recommended before DPT but may be omitted in low-risk patients. The task force suggests a strict definition of such low-risk patients in children and adults. Based on experience and evidence from studies of allergy to beta-lactam antibiotics, an algorithm on how to adjust DPT to the risk, and when to omit skin tests before DPT, is presented. For other antibiotics, non-steroidal anti-inflammatory drugs and other drugs, skin tests are poorly validated and DPT is frequently necessary. We recommend performing DPT with chemotherapeutics and biologicals to avoid unnecessary desensitization procedures and DPT with skin tests negative contrast media. We suggest DPT with anesthetics only in highly specialized centers. Specifics of DPT to proton pump inhibitors, anticonvulsants and corticosteroids are discussed. This position paper provides general recommendations and guidance on optimizing use of DPT, whilst balancing benefits with patient safety and optimizing the use of the limited available resources.

Published
2024

14. Natural History of FPIES

Author

Graham, François, Tsabouri, Sophia, Caubet, Jean-Christoph, Brown-Whitehorn, Terri Faye, editor, and Cianferoni, Antonella, editor

Published
2019
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15. ICER report for peanut OIT comes up short

Author

Eiwegger, Thomas, Anagnostou, Katherine, Arasi, Stefania, Bégin, Philippe, Ben-Shoshan, Moshe, Beyer, Kirsten, Blumchen, Katharina, Brough, Helen, Caubet, Jean-Christoph, Chan, Edmond S., Chinthrajah, Sharon, Davis, Carla M., Roches, Anne Des, Du Toit, George, Elizur, Arnon, Galli, Stephen J., Håland, Geir, Hoffmann-Sommergruber, Karin, Kim, Harold, Leung, Donald Y.M., Muraro, Antonella, Nurmatov, Ulugbek B., Pajno, Giovanni B., Sindher, Sayantani, Szepfalusi, Zsolt, Torres, Maria Jose, Upton, Julia, Worm, Margitta, and Nadeau, Kari

Published
2019
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18. Working with companies that manufacture breastmilk substitutes: An EAACI position paper.

Author

Arasi, Stefania, Caubet, Jean‐Christoph, Ceylan, Ozlem, Eguíluz‐Gracia, Ibon, Del Giacco, Stefano, Gelincik, Aslı, Jutel, Marek, Meyer, Rosan, Ollert, Markus, and Torres, Maria J.

Subjects
*BREAST milk, *INFANT nutrition, *MILK industry, *MEDICAL personnel, *TASK forces
Abstract

Breastmilk is the optimal source of nutrition for infants and should ideally be provided exclusively for the first 6 months of life, and alongside complementary food until 2 years of life. However, there are circumstances where a breastmilk substitute (BMS) may be required. This includes maternal and/or child conditions or personal preference. Whilst these circumstances should never be used as an opportunity to promote BMS, healthcare professionals (HCPs) need to have the knowledge of suitable alternatives and should always be guided by scientific and health motives when recommending a BMS. The Task Force 'Milk Formula Industry Sponsorship' from the European Academy of Allergy and Clinical Immunology (EAACI), provides with this publication recommendations for EAACI interactions with the BMS manufacturers and how this will be supervised. [ABSTRACT FROM AUTHOR]

Published
2024
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21. The severity of allergic reactions in a real-world environment is independent of the eliciting amounts of foods.

Author

Piletta-Zanin, Alexandre, primary, Scherl, Alexander, additional, Benhamou, Avigael, additional, Braendle, Gabriel, additional, Caubet, Jean-Christoph, additional, Graham, François, additional, Grosgurin, Olivier, additional, Harr, Thomas, additional, Manzano, Sergio, additional, Nigolian, Haig, additional, Ortelli, Didier, additional, Pahud, Jean-Pierre, additional, Tour, Aude Tonson la, additional, Spechbach, Hervé, additional, Edder, Patrick, additional, and Eigenmann, Philippe, additional

Published
2023
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25. International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

Author

Nowak-Węgrzyn, Anna, Chehade, Mirna, Groetch, Marion E., Spergel, Jonathan M., Wood, Robert A., Allen, Katrina, Atkins, Dan, Bahna, Sami, Barad, Ashis V., Berin, Cecilia, Brown Whitehorn, Terri, Burks, A. Wesley, Caubet, Jean-Christoph, Cianferoni, Antonella, Conte, Marisa, Davis, Carla, Fiocchi, Alessandro, Grimshaw, Kate, Gupta, Ruchi, Hofmeister, Brittany, Hwang, J.B., Katz, Yitzhak, Konstantinou, George N., Leonard, Stephanie A., Lightdale, Jennifer, McGhee, Sean, Mehr, Sami, Sopo, Stefano Miceli, Monti, Giovanno, Muraro, Antonella, Noel, Stacey Katherine, Nomura, Ichiro, Noone, Sally, Sampson, Hugh A., Schultz, Fallon, Sicherer, Scott H., Thompson, Cecilia C., Turner, Paul J., Venter, Carina, Westcott-Chavez, A. Amity, and Greenhawt, Matthew

Published
2017
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30. International Consensus (ICON): allergic reactions to vaccines

Author

Dreskin, Stephen C., Halsey, Neal A., Kelso, John M., Wood, Robert A., Hummell, Donna S., Edwards, Kathryn M., Caubet, Jean-Christoph, Engler, Renata J.M., Gold, Michael S., Ponvert, Claude, Demoly, Pascal, Sanchez-Borges, Mario, Muraro, Antonella, Li, James T., Rottem, Menachem, and Rosenwasser, Lanny J.

Published
2016
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31. EAACI Molecular Allergology User's Guide 2.0

Author

Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F., de las Vecillas, Leticia, Aalberse, Rob C., Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L., Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A., Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D., Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R., Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K., Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M., Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin

Abstract

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE-mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE-mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well-defined, highly pure molecules for component-resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state-of-the-art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

Published
2023

32. EAACI Molecular Allergology User's Guide 2.0

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, Hoffmann-Sommergruber, Karin, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Dramburg, Stephanie, Hilger, Christiane, Santos, Alexandra F, de Las Vecillas, Leticia, Aalberse, Rob C, Acevedo, Nathalie, Aglas, Lorenz, Altmann, Friedrich, Arruda, Karla L, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Beyer, Kirsten, Biedermann, Tilo, Bilo, Maria Beatrice, Blank, Simon, Bosshard, Philipp P, Breiteneder, Heimo, Brough, Helen A, Bublin, Merima, Campbell, Dianne, Caraballo, Luis, Caubet, Jean Christoph, Celi, Giorgio, Chapman, Martin D, Chruszcz, Maksymilian, Custovic, Adnan, Czolk, Rebecca, Davies, Janet, Douladiris, Nikolaos, Eberlein, Bernadette, Ebisawa, Motohiro, Ehlers, Anna, Eigenmann, Philippe, Gadermaier, Gabriele, Giovannini, Mattia, Gomez, Francisca, Grohman, Rebecca, Guillet, Carole, Hafner, Christine, Hamilton, Robert G, Hauser, Michael, Hawranek, Thomas, Hoffmann, Hans Jürgen, Holzhauser, Thomas, Iizuka, Tomona, Jacquet, Alain, Jakob, Thilo, Janssen-Weets, Bente, Jappe, Uta, Jutel, Marek, Kalic, Tanja, Kamath, Sandip, Kespohl, Sabine, Kleine-Tebbe, Jörg, Knol, Edward, Knulst, André, Konradsen, Jon R, Korošec, Peter, Kuehn, Annette, Lack, Gideon, Le, Thuy-My, Lopata, Andreas, Luengo, Olga, Mäkelä, Mika, Marra, Alessandro Maria, Mills, Clare, Morisset, Martine, Muraro, Antonella, Nowak-Wegrzyn, Anna, Nugraha, Roni, Ollert, Markus, Palosuo, Kati, Pastorello, Elide Anna, Patil, Sarita Ulhas, Platts-Mills, Thomas, Pomés, Anna, Poncet, Pascal, Potapova, Ekaterina, Poulsen, Lars K, Radauer, Christian, Radulovic, Suzana, Raulf, Monika, Rougé, Pierre, Sastre, Joaquin, Sato, Sakura, Scala, Enrico, Schmid, Johannes M, Schmid-Grendelmeier, Peter, Schrama, Denise, Sénéchal, Hélène, Traidl-Hoffmann, Claudia, Valverde-Monge, Marcela, van Hage, Marianne, van Ree, Ronald, Verhoeckx, Kitty, Vieths, Stefan, Wickman, Magnus, Zakzuk, Josefina, Matricardi, Paolo M, and Hoffmann-Sommergruber, Karin

Published
2023

33. EAACI Molecular Allergology User's Guide 2.0

Author

Dramburg, Stephanie; https://orcid.org/0000-0002-9303-3260, Hilger, Christiane; https://orcid.org/0000-0001-9455-5442, Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, de las Vecillas, Leticia; https://orcid.org/0000-0003-4969-5678, Aalberse, Rob C; https://orcid.org/0000-0002-3902-6596, Acevedo, Nathalie; https://orcid.org/0000-0002-5154-2964, Aglas, Lorenz; https://orcid.org/0000-0002-1236-5934, Altmann, Friedrich; https://orcid.org/0000-0002-0112-7877, Arruda, Karla L; https://orcid.org/0000-0002-7505-210X, Asero, Riccardo; https://orcid.org/0000-0002-8277-1700, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barber, Domingo; https://orcid.org/0000-0002-5488-5700, Beyer, Kirsten; https://orcid.org/0000-0003-1859-0419, Biedermann, Tilo; https://orcid.org/0000-0002-5352-5105, Bilo, Maria Beatrice; https://orcid.org/0000-0002-9324-6039, Blank, Simon; https://orcid.org/0000-0002-5649-1078, Bosshard, Philipp P; https://orcid.org/0000-0002-1154-2281, Breiteneder, Heimo; https://orcid.org/0000-0003-2022-8689, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Bublin, Merima; https://orcid.org/0000-0002-7191-9431, Campbell, Dianne; https://orcid.org/0000-0002-0907-6963, Caraballo, Luis; https://orcid.org/0000-0002-5204-1109, Caubet, Jean Christoph; https://orcid.org/0000-0001-5006-5724, Celi, Giorgio, Chapman, Martin D; https://orcid.org/0000-0002-0845-3632, Chruszcz, Maksymilian; https://orcid.org/0000-0001-7521-5485, Custovic, Adnan; https://orcid.org/0000-0001-5218-7071, Czolk, Rebecca; https://orcid.org/0000-0003-4296-3051, Davies, Janet; https://orcid.org/0000-0002-6378-4119, Douladiris, Nikolaos; https://orcid.org/0000-0003-4037-4421, et al, Dramburg, Stephanie; https://orcid.org/0000-0002-9303-3260, Hilger, Christiane; https://orcid.org/0000-0001-9455-5442, Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, de las Vecillas, Leticia; https://orcid.org/0000-0003-4969-5678, Aalberse, Rob C; https://orcid.org/0000-0002-3902-6596, Acevedo, Nathalie; https://orcid.org/0000-0002-5154-2964, Aglas, Lorenz; https://orcid.org/0000-0002-1236-5934, Altmann, Friedrich; https://orcid.org/0000-0002-0112-7877, Arruda, Karla L; https://orcid.org/0000-0002-7505-210X, Asero, Riccardo; https://orcid.org/0000-0002-8277-1700, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barber, Domingo; https://orcid.org/0000-0002-5488-5700, Beyer, Kirsten; https://orcid.org/0000-0003-1859-0419, Biedermann, Tilo; https://orcid.org/0000-0002-5352-5105, Bilo, Maria Beatrice; https://orcid.org/0000-0002-9324-6039, Blank, Simon; https://orcid.org/0000-0002-5649-1078, Bosshard, Philipp P; https://orcid.org/0000-0002-1154-2281, Breiteneder, Heimo; https://orcid.org/0000-0003-2022-8689, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Bublin, Merima; https://orcid.org/0000-0002-7191-9431, Campbell, Dianne; https://orcid.org/0000-0002-0907-6963, Caraballo, Luis; https://orcid.org/0000-0002-5204-1109, Caubet, Jean Christoph; https://orcid.org/0000-0001-5006-5724, Celi, Giorgio, Chapman, Martin D; https://orcid.org/0000-0002-0845-3632, Chruszcz, Maksymilian; https://orcid.org/0000-0001-7521-5485, Custovic, Adnan; https://orcid.org/0000-0001-5218-7071, Czolk, Rebecca; https://orcid.org/0000-0003-4296-3051, Davies, Janet; https://orcid.org/0000-0002-6378-4119, Douladiris, Nikolaos; https://orcid.org/0000-0003-4037-4421, and et al

Abstract

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

Published
2023

34. EAACI Molecular Allergology User's Guide 2.0

Author

Dramburg, Stephanie, primary, Hilger, Christiane, additional, Santos, Alexandra F., additional, de las Vecillas, Leticia, additional, Aalberse, Rob C., additional, Acevedo, Nathalie, additional, Aglas, Lorenz, additional, Altmann, Friedrich, additional, Arruda, Karla L., additional, Asero, Riccardo, additional, Ballmer‐Weber, Barbara, additional, Barber, Domingo, additional, Beyer, Kirsten, additional, Biedermann, Tilo, additional, Bilo, Maria Beatrice, additional, Blank, Simon, additional, Bosshard, Philipp P., additional, Breiteneder, Heimo, additional, Brough, Helen A., additional, Bublin, Merima, additional, Campbell, Dianne, additional, Caraballo, Luis, additional, Caubet, Jean Christoph, additional, Celi, Giorgio, additional, Chapman, Martin D., additional, Chruszcz, Maksymilian, additional, Custovic, Adnan, additional, Czolk, Rebecca, additional, Davies, Janet, additional, Douladiris, Nikolaos, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Ehlers, Anna, additional, Eigenmann, Philippe, additional, Gadermaier, Gabriele, additional, Giovannini, Mattia, additional, Gomez, Francisca, additional, Grohman, Rebecca, additional, Guillet, Carole, additional, Hafner, Christine, additional, Hamilton, Robert G., additional, Hauser, Michael, additional, Hawranek, Thomas, additional, Hoffmann, Hans Jürgen, additional, Holzhauser, Thomas, additional, Iizuka, Tomona, additional, Jacquet, Alain, additional, Jakob, Thilo, additional, Janssen‐Weets, Bente, additional, Jappe, Uta, additional, Jutel, Marek, additional, Kalic, Tanja, additional, Kamath, Sandip, additional, Kespohl, Sabine, additional, Kleine‐Tebbe, Jörg, additional, Knol, Edward, additional, Knulst, André, additional, Konradsen, Jon R., additional, Korošec, Peter, additional, Kuehn, Annette, additional, Lack, Gideon, additional, Le, Thuy‐My, additional, Lopata, Andreas, additional, Luengo, Olga, additional, Mäkelä, Mika, additional, Marra, Alessandro Maria, additional, Mills, Clare, additional, Morisset, Martine, additional, Muraro, Antonella, additional, Nowak‐Wegrzyn, Anna, additional, Nugraha, Roni, additional, Ollert, Markus, additional, Palosuo, Kati, additional, Pastorello, Elide Anna, additional, Patil, Sarita Ulhas, additional, Platts‐Mills, Thomas, additional, Pomés, Anna, additional, Poncet, Pascal, additional, Potapova, Ekaterina, additional, Poulsen, Lars K., additional, Radauer, Christian, additional, Radulovic, Suzana, additional, Raulf, Monika, additional, Rougé, Pierre, additional, Sastre, Joaquin, additional, Sato, Sakura, additional, Scala, Enrico, additional, Schmid, Johannes M., additional, Schmid‐Grendelmeier, Peter, additional, Schrama, Denise, additional, Sénéchal, Hélène, additional, Traidl‐Hoffmann, Claudia, additional, Valverde‐Monge, Marcela, additional, van Hage, Marianne, additional, van Ree, Ronald, additional, Verhoeckx, Kitty, additional, Vieths, Stefan, additional, Wickman, Magnus, additional, Zakzuk, Josefina, additional, Matricardi, Paolo M., additional, and Hoffmann‐Sommergruber, Karin, additional

Published
2023
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