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1. AR Structural Variants and Prostate Cancer

Author

Cato, Laura, Shomali, Maysoun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Campbell, Moray J., editor, and Bevan, Charlotte L., editor

Published
2022
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2. Supplementary Figure 7 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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3. Supplementary Figure 12 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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4. Data from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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5. Supplementary Figure 3 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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6. Supplementary Figure 2 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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7. Supplementary Table 5 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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8. Supplementary Figure 9 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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9. Supplementary Table 6 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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10. Supplementary Table 1 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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11. Supplementary Table 3 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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12. Supplementary Figure 8 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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13. Supplementary Materials and Methods from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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14. Supplementary Figure 5 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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15. Supplementary Figure 6 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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16. Supplementary Table 7 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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17. Supplementary Table 4 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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18. Supplementary Table 2 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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19. Supplementary Figure 4 from Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, primary, Bogdan, Denisa, primary, Cato, Laura, primary, Stober, Jutta, primary, Jiménez-Vacas, Juan M., primary, Gourain, Victor, primary, Lee, Irene I., primary, Seeger, Rebecca, primary, Muhle-Goll, Claudia, primary, Gurel, Bora, primary, Welti, Jonathan, primary, Nava Rodrigues, Daniel, primary, Rekowski, Jan, primary, Qiu, Xintao, primary, Jiang, Yija, primary, Di Micco, Patrizio, primary, Mateos, Borja, primary, Bielskutė, Stasė, primary, Riisnaes, Ruth, primary, Ferreira, Ana, primary, Miranda, Susana, primary, Crespo, Mateus, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Bräse, Stefan, primary, Jung, Nicole, primary, Gräßle, Simone, primary, Swain, Amanda, primary, Salvatella, Xavier, primary, Plymate, Stephen R., primary, Al-Lazikani, Bissan, primary, Long, Henry W., primary, Yuan, Wei, primary, Brown, Myles, primary, Cato, Andrew C.B., primary, de Bono, Johann S., primary, and Sharp, Adam, primary

Published
2024
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20. A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway

Author

Kuznik, Nane C., Solozobova, Valeria, Lee, Irene I., Jung, Nicole, Yang, Linxiao, Nienhaus, Karin, Ntim, Emmanuel A., Rottenberg, Jaice T., Muhle-Goll, Claudia, Kumar, Amrish Rajendra, Peravali, Ravindra, Gräßle, Simone, Gourain, Victor, Deville, Célia, Cato, Laura, Neeb, Antje, Dilger, Marco, Cramer von Clausbruch, Christina A., Weiss, Carsten, Kieffer, Bruno, Nienhaus, G. Ulrich, Brown, Myles, Bräse, Stefan, and Cato, Andrew C.B.

Published
2022
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21. Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting.

Author

Luo, Jun, Attard, Gerhardt, Balk, Steven, Bevan, Charlotte, Burnstein, Kerry, Cato, Laura, Cherkasov, Artem, De Bono, Johann, Dong, Yan, Gao, Allen, Gleave, Martin, Heemers, Hannelore, Kanayama, Mayuko, Kittler, Ralf, Lang, Joshua, Lee, Richard, Logothetis, Christopher, Matusik, Robert, Plymate, Stephen, Sawyers, Charles, Selth, Luke, Soule, Howard, Tilley, Wayne, Weigel, Nancy, Zoubeidi, Amina, Dehm, Scott, and Raj, Ganesh

Subjects
Abiraterone, Androgen receptor variant 7, Androgen receptor variants, Castration-resistant prostate cancer, Enzalutamide, Aged, Androgen Antagonists, Androstenes, Benzamides, Biomarkers, Tumor, Congresses as Topic, Disease-Free Survival, Follow-Up Studies, Humans, Male, Middle Aged, Nitriles, Phenylthiohydantoin, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, Risk Assessment, Survival Analysis, Treatment Outcome
Abstract

CONTEXT: Although a number of studies have demonstrated the importance of constitutively active androgen receptor variants (AR-Vs) in prostate cancer, questions still remain about the precise role of AR-Vs in the progression of castration-resistant prostate cancer (CRPC). OBJECTIVE: Key stakeholders and opinion leaders in prostate cancer convened on May 11, 2017 in Boston to establish the current state of the field of AR-Vs. EVIDENCE ACQUISITION: The meeting Mission Androgen Receptor Variants was the second of its kind sponsored by the Prostate Cancer Foundation (PCF). This invitation-only event was attended by international leaders in the field and representatives from sponsoring organizations (PCF and industry sponsors). Eighteen faculty members gave short presentations, which were followed by in-depth discussions. Discussions focused on three thematic topics: (1) potential of AR-Vs as biomarkers of therapeutic resistance; (2) role of AR-Vs as functionally active CRPC progression drivers; and (3) utility of AR-Vs as therapeutic targets in CRPC. EVIDENCE SYNTHESIS: The three meeting organizers synthesized this meeting report, which is intended to summarize major data discussed at the meeting and identify key questions as well as strategies for addressing these questions. There was a critical consensus that further study of the AR-Vs is an important research focus in CRPC. Contrasting views and emphasis, each supported by data, were presented at the meeting, discussed among the participants, and synthesized in this report. CONCLUSIONS: This article highlights the state of knowledge and outlines the most pressing questions that need to be addressed to advance the AR-V field. PATIENT SUMMARY: Although further investigation is needed to delineate the role of androgen receptor (AR) variants in metastatic castration-resistant prostate cancer, advances in measurement science have enabled development of blood-based tests for treatment selection. Detection of AR variants (eg, AR-V7) identified a patient population with poor outcomes to existing AR-targeting therapies, highlighting the need for novel therapeutic agents currently under development.

Published
2018

23. Thio-2 inhibits key signaling pathways required for the development and progression of castration resistant prostate cancer.

Author

Neeb, Antje, primary, Figueiredo, Ines, additional, Bogdan, Denisa, additional, Cato, Laura, additional, Stober, Jutta, additional, Jiménez-Vacas, Juan M., additional, Gourain, Victor, additional, Lee, Irene I., additional, Seeger, Rebecca, additional, Muhle-Goll, Claudia, additional, Gurel, Bora, additional, Welti, Jonathan, additional, Nava Rodrigues, Daniel, additional, Rekowski, Jan, additional, Qiu, Xintao, additional, Jiang, Yija, additional, Di Micco, Patrizio, additional, Mateos, Borja, additional, Bielskutė, Stasė, additional, Riisnaes, Ruth, additional, Ferreira, Ana, additional, Miranda, Susana, additional, Crespo, Mateus, additional, Buroni, Lorenzo, additional, Ning, Jian, additional, Carreira, Suzanne, additional, Bräse, Stefan, additional, Jung, Nicole, additional, Gräßle, Simone, additional, Swain, Amanda, additional, Salvatella, Xavier, additional, Plymate, Stephen R., additional, Al-Lazikani, Bissan, additional, Long, Henry W., additional, Yuan, Wei, additional, Brown, Myles, additional, Cato, Andrew C.B., additional, de Bono, Johann S., additional, and Sharp, Adam, additional

Published
2024
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28. Supplementary Data from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy

Author

Pan, Mengwu, primary, Solozobova, Valeria, primary, Kuznik, Nane C., primary, Jung, Nicole, primary, Gräßle, Simone, primary, Gourain, Victor, primary, Heneka, Yvonne M., primary, Cramer von Clausbruch, Christina A., primary, Fuhr, Olaf, primary, Munuganti, Ravi S. N., primary, Maddalo, Danilo, primary, Blattner, Christine, primary, Neeb, Antje, primary, Sharp, Adam, primary, Cato, Laura, primary, Weiss, Carsten, primary, Jeselsohn, Rinath M., primary, Orian-Rousseau, Veronique, primary, Bräse, Stefan, primary, and Cato, Andrew C. B., primary

Published
2023
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29. Supplementary Table S2 from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy

Author

Pan, Mengwu, primary, Solozobova, Valeria, primary, Kuznik, Nane C., primary, Jung, Nicole, primary, Gräßle, Simone, primary, Gourain, Victor, primary, Heneka, Yvonne M., primary, Cramer von Clausbruch, Christina A., primary, Fuhr, Olaf, primary, Munuganti, Ravi S. N., primary, Maddalo, Danilo, primary, Blattner, Christine, primary, Neeb, Antje, primary, Sharp, Adam, primary, Cato, Laura, primary, Weiss, Carsten, primary, Jeselsohn, Rinath M., primary, Orian-Rousseau, Veronique, primary, Bräse, Stefan, primary, and Cato, Andrew C. B., primary

Published
2023
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30. Data from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy

Author

Pan, Mengwu, primary, Solozobova, Valeria, primary, Kuznik, Nane C., primary, Jung, Nicole, primary, Gräßle, Simone, primary, Gourain, Victor, primary, Heneka, Yvonne M., primary, Cramer von Clausbruch, Christina A., primary, Fuhr, Olaf, primary, Munuganti, Ravi S. N., primary, Maddalo, Danilo, primary, Blattner, Christine, primary, Neeb, Antje, primary, Sharp, Adam, primary, Cato, Laura, primary, Weiss, Carsten, primary, Jeselsohn, Rinath M., primary, Orian-Rousseau, Veronique, primary, Bräse, Stefan, primary, and Cato, Andrew C. B., primary

Published
2023
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31. Figure S1 from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy

Author

Pan, Mengwu, primary, Solozobova, Valeria, primary, Kuznik, Nane C., primary, Jung, Nicole, primary, Gräßle, Simone, primary, Gourain, Victor, primary, Heneka, Yvonne M., primary, Cramer von Clausbruch, Christina A., primary, Fuhr, Olaf, primary, Munuganti, Ravi S. N., primary, Maddalo, Danilo, primary, Blattner, Christine, primary, Neeb, Antje, primary, Sharp, Adam, primary, Cato, Laura, primary, Weiss, Carsten, primary, Jeselsohn, Rinath M., primary, Orian-Rousseau, Veronique, primary, Bräse, Stefan, primary, and Cato, Andrew C. B., primary

Published
2023
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32. Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy

Author

Pan, Mengwu, primary, Solozobova, Valeria, additional, Kuznik, Nane C., additional, Jung, Nicole, additional, Gräßle, Simone, additional, Gourain, Victor, additional, Heneka, Yvonne M., additional, Cramer von Clausbruch, Christina A., additional, Fuhr, Olaf, additional, Munuganti, Ravi S. N., additional, Maddalo, Danilo, additional, Blattner, Christine, additional, Neeb, Antje, additional, Sharp, Adam, additional, Cato, Laura, additional, Weiss, Carsten, additional, Jeselsohn, Rinath M., additional, Orian-Rousseau, Veronique, additional, Bräse, Stefan, additional, and Cato, Andrew C. B., additional

Published
2023
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34. Contributors

Author

Ataman, Lauren, primary, Auchus, Richard J., additional, Bach, Phil Vu, additional, Barbieri, Robert L., additional, Barnhart, Kurt, additional, Porter, Misty Blanchette, additional, Brannigan, Robert E., additional, Brown, Myles, additional, Bulun, Serdar E., additional, Carmina, Enrico, additional, Carrell, Douglas T., additional, Cato, Laura, additional, Chang, Alice Y., additional, Chang, R. Jeffrey, additional, Cidlowski, John A., additional, Délot, Emmanuèle C., additional, Dias, James A., additional, Dumesic, Daniel A., additional, Duncan, Francesca E., additional, Edlow, Andrea G., additional, Edmonds, Maxwell, additional, Evans, William S., additional, Fauser, Bart C.J.M., additional, Feinberg, Eve, additional, FitzGerald, Garrett A., additional, Ginsburg, Elizabeth S., additional, Giudice, Linda C., additional, Goldstein, Steven, additional, Hall, Janet E., additional, Jeselsohn, Rinath, additional, Kaser, Daniel J., additional, Khan, Zaraq, additional, Klibanski, Anne, additional, Kondapalli, Laxmi A., additional, Kutteh, William Hanna, additional, Lessey, Bruce A., additional, Liu, Peter Y., additional, Lobo, Rogerio A., additional, Marsh, Philip, additional, Marshall, John C., additional, Matzuk, Martin M., additional, McCartney, Christopher R., additional, Mesiano, Sam, additional, Narayan, Prema, additional, Nass, Ralf, additional, Norwitz, Errol R., additional, Olivera, Giovanna, additional, Pangas, Stephanie A., additional, Polotsky, Alex J., additional, Quinn, Molly, additional, Racowsky, Catherine, additional, Ribeiro, Salustiano, additional, Rieder, Jessica, additional, Rodriguez, Amanda, additional, Rosen, Mitchell, additional, Runge, Andrew, additional, Safer, Joshua D., additional, Santoro, Nanette, additional, Schlegel, Peter N., additional, Schreiber, Courtney A., additional, Schust, Danny Joseph, additional, Simbulan, Rhodel, additional, Snyder, Peter J., additional, Stanczyk, Frank Z., additional, Stanic, Aleksandar K., additional, Stewart, Elizabeth A., additional, Strauss, Jerome F., additional, Sutton, Patrice, additional, Topaloglu, A. Kemal, additional, Tritos, Nicholas A., additional, Ulloa-Aguirre, Alfredo, additional, Veldhuis, Johannes D., additional, Vilain, Eric, additional, Webb, Rebecca, additional, Whirledge, Shannon, additional, Williams, Carmen J., additional, Witchel, Selma Feldman, additional, Woodruff, Teresa K., additional, Woodruff, Tracey J., additional, Yang, Xinli, additional, Young, Steven L., additional, and Zlatnik, Marya G., additional

Published
2019
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35. Targeting the BAG-1 family of co-chaperones in lethal prostate cancer

Author

Neeb, Antje, primary, Figueiredo, Ines, additional, Bogdan, Denisa, additional, Cato, Laura, additional, Stober, Jutta, additional, Jimenez-Vacas, Juan M., additional, Gourain, Victor, additional, Lee, Irene I., additional, Seeger, Rebecca, additional, Muhle-Goll, Claudia, additional, Gurel, Bora, additional, Welti, Jonathan, additional, Rodrigues, Daniel Nava, additional, Rekowski, Jan, additional, Qiu, Xintao, additional, Jiang, Yija, additional, Di Micco, Patrizio, additional, Mateos, Borja, additional, Bielskutė, Stasė, additional, Riisnaes, Ruth, additional, Ferreira, Ana, additional, Miranda, Susana, additional, Crespo, Mateus, additional, Buroni, Lorenzo, additional, Ning, Jian, additional, Bräse, Stefan, additional, Jung, Nicole, additional, Gräßle, Simone, additional, Metzger, Daniel, additional, Swain, Amanda, additional, Salvatella, Xavier, additional, Plymate, Stephen R., additional, Al-Lazikani, Bissan, additional, Long, Henry, additional, Yuan, Wei, additional, Brown, Myles, additional, Cato, Andrew C. B., additional, de Bono, Johann S., additional, and Sharp, Adam, additional

Published
2022
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36. EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

Author

Xu, Kexin, Wu, Zhenhua Jeremy, Groner, Anna C., He, Housheng Hansen, Cai, Changmeng, Lis, Rosina T., Wu, Xiaoqiu, Stack, Edward C., Loda, Massimo, Liu, Tao, Xu, Han, Cato, Laura, Thornton, James E., Gregory, Richard I., Morrissey, Colm, Vessella, Robert L., Montironi, Rodolfo, Magi-Galluzzi, Cristina, Kantoff, Philip W., Balk, Steven P., Liu, X. Shirley, and Brown, Myles

Published
2012
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37. Androgen receptor splice variant 7 functions independently of the full length receptor in prostate cancer cells

Author

Liang, Jiaqian, primary, Wang, Liyang, additional, Poluben, Larysa, additional, Nouri, Mannan, additional, Arai, Seiji, additional, Xie, Lisha, additional, Voznesensky, Olga S., additional, Cato, Laura, additional, Yuan, Xin, additional, Russo, Joshua W., additional, Long, Henry W., additional, Brown, Myles, additional, Chen, Shaoyong, additional, and Balk, Steven P., additional

Published
2021
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40. EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-lndependent

Author

Xu, Kexin, Wu, Zhenhua Jeremy, Groner, Anna C., Hansen He, Housheng, Cai, Changmeng, Lis, Rosina T., Wu, Xiaoqiu, Stack, Edward C., Loda, Massimo, Liu, Tao, Xu, Han, Cato, Laura, Thornton, James E., Gregory, Richard I., Morrissey, Colm, Vessella, Robert L., Montironi, Rodolfo, Magi-Galluzzi, Cristina, Kantoff, Philip W., Balk, Steven P., Liu, Shirley X., and Brown, Myles

Published
2012
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42. ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

Author

Cato, Laura, primary, de Tribolet-Hardy, Jonas, additional, Lee, Irene, additional, Rottenberg, Jaice T., additional, Coleman, Ilsa, additional, Melchers, Diana, additional, Houtman, René, additional, Xiao, Tengfei, additional, Li, Wei, additional, Uo, Takuma, additional, Sun, Shihua, additional, Kuznik, Nane C., additional, Göppert, Bettina, additional, Ozgun, Fatma, additional, van Royen, Martin E., additional, Houtsmuller, Adriaan B., additional, Vadhi, Raga, additional, Rao, Prakash K., additional, Li, Lewyn, additional, Balk, Steven P., additional, Den, Robert B., additional, Trock, Bruce J., additional, Karnes, R. Jeffrey, additional, Jenkins, Robert B., additional, Klein, Eric A., additional, Davicioni, Elai, additional, Gruhl, Friederike J., additional, Long, Henry W., additional, Liu, X. Shirley, additional, Cato, Andrew C.B., additional, Lack, Nathan A., additional, Nelson, Peter S., additional, Plymate, Stephen R., additional, Groner, Anna C., additional, and Brown, Myles, additional

Published
2019
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43. Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Author

Cato, Laura, primary, Neeb, Antje, additional, Sharp, Adam, additional, Buzón, Victor, additional, Ficarro, Scott B, additional, Yang, Linxiao, additional, Muhle-Goll, Claudia, additional, Kuznik, Nane C, additional, Riisnaes, Ruth, additional, Nava Rodrigues, Daniel, additional, Armant, Olivier, additional, Gourain, Victor, additional, Adelmant, Guillaume, additional, Ntim, Emmanuel A, additional, Westerling, Thomas, additional, Dolling, David, additional, Rescigno, Pasquale, additional, Figueiredo, Ines, additional, Fauser, Friedrich, additional, Wu, Jennifer, additional, Rottenberg, Jaice T, additional, Shatkina, Liubov, additional, Ester, Claudia, additional, Luy, Burkhard, additional, Puchta, Holger, additional, Troppmair, Jakob, additional, Jung, Nicole, additional, Bräse, Stefan, additional, Strähle, Uwe, additional, Marto, Jarrod A, additional, Nienhaus, Gerd Ulrich, additional, Al-Lazikani, Bissan, additional, Salvatella, Xavier, additional, de Bono, Johann S, additional, Cato, Andrew CB, additional, and Brown, Myles, additional

Published
2017
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44. Author response: Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

Author

Cato, Laura, primary, Neeb, Antje, additional, Sharp, Adam, additional, Buzón, Victor, additional, Ficarro, Scott B, additional, Yang, Linxiao, additional, Muhle-Goll, Claudia, additional, Kuznik, Nane C, additional, Riisnaes, Ruth, additional, Nava Rodrigues, Daniel, additional, Armant, Olivier, additional, Gourain, Victor, additional, Adelmant, Guillaume, additional, Ntim, Emmanuel A, additional, Westerling, Thomas, additional, Dolling, David, additional, Rescigno, Pasquale, additional, Figueiredo, Ines, additional, Fauser, Friedrich, additional, Wu, Jennifer, additional, Rottenberg, Jaice T, additional, Shatkina, Liubov, additional, Ester, Claudia, additional, Luy, Burkhard, additional, Puchta, Holger, additional, Troppmair, Jakob, additional, Jung, Nicole, additional, Bräse, Stefan, additional, Strähle, Uwe, additional, Marto, Jarrod A, additional, Nienhaus, Gerd Ulrich, additional, Al-Lazikani, Bissan, additional, Salvatella, Xavier, additional, de Bono, Johann S, additional, Cato, Andrew CB, additional, and Brown, Myles, additional

Published
2017
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45. Abstract 1806: TRIM24 is an oncogenic transcriptional activator in prostate cancer

Author

Groner, Anna C., primary, Cato, Laura, additional, de Tribolet-Hardy, Jonas, additional, Bernasocchi, Tiziano, additional, Zhong, Qing, additional, Fankhauser, Christian, additional, Fritz, Christine, additional, Poyet, Cédric, additional, Wagner, Ulrich, additional, Garraway, Levi A., additional, Wild, Peter J., additional, Theurillat, Jean-Philippe, additional, and Brown, Myles, additional

Published
2016
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47. TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer

Author

Groner, Anna C., primary, Cato, Laura, additional, de Tribolet-Hardy, Jonas, additional, Bernasocchi, Tiziano, additional, Janouskova, Hana, additional, Melchers, Diana, additional, Houtman, René, additional, Cato, Andrew C.B., additional, Tschopp, Patrick, additional, Gu, Lei, additional, Corsinotti, Andrea, additional, Zhong, Qing, additional, Fankhauser, Christian, additional, Fritz, Christine, additional, Poyet, Cédric, additional, Wagner, Ulrich, additional, Guo, Tiannan, additional, Aebersold, Ruedi, additional, Garraway, Levi A., additional, Wild, Peter J., additional, Theurillat, Jean-Philippe, additional, and Brown, Myles, additional

Published
2016
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48. Highly disordered histone H1--DNA model complexes and their condensates.

Author

Turner, Abigail L., Watson, Matthew, Wilkins, Oscar G., Thomas, Jean O., Stott, Katherine, Cato, Laura, and Travers, Andrew

Subjects
HISTONES, CHROMATIN, PHOSPHORYLATION, PHASE separation, POLYMERS
Abstract

Disordered proteins play an essential role in a wide variety of biological processes, and are often posttranslationally modified. One such protein is histone H1; its highly disordered C-terminal tail (CH1) condenses internucleosomal linker DNA in chromatin in a way that is still poorly understood. Moreover, CH1 is phosphorylated in a cell cycle-dependent manner that correlates with changes in the chromatin condensation level. Here we present a model system that recapitulates key aspects of the in vivo process, and also allows a detailed structural and biophysical analysis of the stages before and after condensation. CH1 remains disordered in the DNA-bound state, despite its nanomolar affinity. Phase-separated droplets (coacervates) form, containing higher-order assemblies of CH1/DNA complexes. Phosphorylation at three serine residues, spaced along the length of the tail, has little effect on the local properties of the condensate. However, it dramatically alters higher-order structure in the coacervate and reduces partitioning to the coacervate phase. These observations show that disordered proteins can bind tightly to DNA without a disorder-to-order transition. Importantly, they also provide mechanistic insights into how higher-order structures can be exquisitely sensitive to perturbation by posttranslational modifications, thus broadening the repertoire of mechanisms that might regulate chromatin and other macromolecular assemblies. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

Author

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Cato, Laura, Peng Zhang, Cotter, Maura B., Bowden, Michaela, Lis, Rosina T., Zhao, Shuang G., Qiu Wu, Feng, Felix Y., Loda, Massimo, Housheng Hansen He, Liu, X. Shirley, and Brown, Myles

Subjects
PROSTATE cancer treatment, CRISPRS, NUCLEOPROTEINS, ALTERNATIVE RNA splicing, RNA-binding proteins, IMMUNOPRECIPITATION
Abstract

Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes, including most notably heterogeneous nuclear ribonucleoprotein L (HNRNPL). We defined the HNRNPL-bound RNA landscape by RNA immunoprecipitation coupled with next-generation sequencing and linked these RBP-RNA interactions to changes in RNA processing. HNRNPL directly regulates the alternative splicing of a set of RNAs, including those encoding the androgen receptor, the key lineage-specific prostate cancer oncogene. HNRNPL also regulates circular RNA formation via back splicing. Importantly, both HNRNPL and its RNA targets are aberrantly expressed in human prostate tumors, supporting their clinical relevance. Collectively, our data reveal HNRNPL and its RNA clients as players in prostate cancer growth and potential therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2017
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