1. Do small effects matter more in vulnerable populations? an investigation using Environmental influences on Child Health Outcomes (ECHO) cohorts
- Author
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Janet L. Peacock, Susana Diaz Coto, Judy R. Rees, Odile Sauzet, Elizabeth T. Jensen, Raina Fichorova, Anne L. Dunlop, Nigel Paneth, Amy Padula, Tracey Woodruff, Rachel Morello-Frosch, Jessica Trowbridge, Dana Goin, Luis E. Maldonado, Zhongzheng Niu, Akhgar Ghassabian, Leonardo Transande, Assiamira Ferrara, Lisa A. Croen, Stacey Alexeeff, Carrie Breton, Augusto Litonjua, Thomas G. O’Connor, Kristen Lyall, Heather Volk, Akram Alshawabkeh, Justin Manjourides, Carlos A. Camargo, Dana Dabelea, Christine W. Hockett, Casper G. Bendixsen, Irva Hertz-Picciotto, Rebecca J. Schmidt, Alison E. Hipwell, Kate Keenan, Catherine Karr, Kaja Z. LeWinn, Barry Lester, Marie Camerota, Jody Ganiban, Cynthia McEvoy, Michael R. Elliott, Sheela Sathyanarayana, Nan Ji, Joseph M. Braun, Margaret R. Karagas, and on behalf of Program Collaborators for Environmental influences on Child Health Outcomes
- Subjects
Pregnancy outcomes ,Child health outcome ,Health disparities ,Environmental exposure ,Social determinants of health ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background A major challenge in epidemiology is knowing when an exposure effect is large enough to be clinically important, in particular how to interpret a difference in mean outcome in unexposed/exposed groups. Where it can be calculated, the proportion/percentage beyond a suitable cut-point is useful in defining individuals at high risk to give a more meaningful outcome. In this simulation study we compute differences in outcome means and proportions that arise from hypothetical small effects in vulnerable sub-populations. Methods Data from over 28,000 mother/child pairs belonging to the Environmental influences on Child Health Outcomes Program were used to examine the impact of hypothetical environmental exposures on mean birthweight, and low birthweight (LBW) (birthweight
- Published
- 2024
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