Author: "Catherine Boisson" - Searchworks@Jio Institute Digital Library Search Results

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1. In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia

Author: Rida Al-Rifai, Philippe Nguyen, Nicole Bouland, Christine Terryn, Lukshe Kanagaratnam, Gaël Poitevin, Caroline François, Catherine Boisson-Vidal, Marie-Antoinette Sevestre, and Claire Tournois
Subjects: Angiogenesis, Cell therapy, Critical limb ischemia, Mesenchymal stem cells, Medicine
Abstract: Abstract Background Cell therapy has been proposed for patients with critical limb ischemia (CLI). Autologous bone marrow derived cells (BMCs) have been mostly used, mesenchymal stem cells (MSCs) being an alternative. The aim of this study was to characterize two types of MSCs and evaluate their efficacy. Methods MSCs were obtained from CLI-patients BMCs. Stimulated- (S-) MSCs were cultured in endothelial growth medium. Cells were characterized by the expression of cell surface markers, the relative expression of 6 genes, the secretion of 10 cytokines and the ability to form vessel-like structures. The cell proangiogenic properties was analysed in vivo, in a hindlimb ischemia model. Perfusion of lower limbs and functional tests were assessed for 28 days after cell infusion. Muscle histological analysis (neoangiogenesis, arteriogenesis and muscle repair) was performed. Results S-MSCs can be obtained from CLI-patients BMCs. They do not express endothelial specific markers but can be distinguished from MSCs by their secretome. S-MSCs have the ability to form tube-like structures and, in vivo, to induce blood flow recovery. No amputation was observed in S-MSCs treated mice. Functional tests showed improvement in treated groups with a superiority of MSCs and S-MSCs. In muscles, CD31+ and αSMA+ labelling were the highest in S-MSCs treated mice. S-MSCs induced the highest muscle repair. Conclusions S-MSCs exert angiogenic potential probably mediated by a paracrine mechanism. Their administration is associated with flow recovery, limb salvage and muscle repair. The secretome from S-MSCs or secretome-derived products may have a strong potential in vessel regeneration and muscle repair. Trial registration NCT00533104
Published: 2019
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2. In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent

Author: Cécilia Delattre, Diego Velazquez, Caroline Roques, Graciela Pavon-Djavid, Véronique Ollivier, Anna Lokajczyk, Thierry Avramoglou, Virginie Gueguen, Liliane Louedec, Giuseppina Caligiuri, Martine Jandrot-Perrus, Catherine Boisson-Vidal, Didier Letourneur, and Anne Meddahi-Pelle
Subjects: animal model, biocompatibility, dextran, haemocompatibility, in vitro, stent, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Introduction: The major complications of stent implantation are restenosis and late stent thrombosis. PBMA polymers are used for stent coating because of their mechanical properties. We previously synthesized and characterized Dextrangraft-polybutylmethacrylate copolymer (Dex-PBMA) as a potential stent coating. In this study, we evaluated the haemocompatibility and biocompatibility properties of Dex-PBMA in vitro and in vivo. Methods: Here, we investigated: (1) the effectiveness of polymer coating under physiological conditions and its ability to release Tacrolimus®, (2) the capacity of Dex-PBMA to inhibit Staphylococcus aureus adhesion, (3) the thrombin generation and the human platelet adhesion in static and dynamic conditions, (4) the biocompatibility properties in vitro on human endothelial colony forming cells ( ECFC) and on mesenchymal stem cells (MSC) and in vivo in rat models, and (5) we implanted Dex-PBMA and Dex-PBMATAC coated stents in neointimal hyperplasia restenosis rabbit model. Results: Dex-PBMA coating efficiently prevented bacterial adhesion and release Tacrolimus®. Dex-PBMA exhibit haemocompatibility properties under flow and ECFC and MSC compatibility. In vivo, no pathological foreign body reaction was observed neither after intramuscular nor intravascular aortic implantation. After Dex-PBMA and Dex-PBMATAC coated stents 30 days implantation in a restenosis rabbit model, an endothelial cell coverage was observed and the lumen patency was preserved. Conclusion: Based on our findings, Dex-PBMA exhibited vascular compatibility and can potentially be used as a coating for metallic coronary stents.
Published: 2019
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3. Acidic preconditioning of endothelial colony-forming cells (ECFC) promote vasculogenesis under proinflammatory and high glucose conditions in vitro and in vivo

Author: Hebe Agustina Mena, Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal, and Soledad Negrotto
Subjects: Type 2 diabetes, Inflammation, Human endothelial colony forming cells, Hind limb ischemia, Acidic preconditioning, Angiogenesis, Medicine (General), R5-920, Biochemistry, QD415-436
Abstract: Abstract Background We have previously demonstrated that acidic preconditioning of human endothelial colony-forming cells (ECFC) increased proliferation, migration, and tubulogenesis in vitro, and increased their regenerative potential in a murine model of hind limb ischemia without baseline disease. We now analyze whether this strategy is also effective under adverse conditions for vasculogenesis, such as the presence of ischemia-related toxic molecules or diabetes, one of the main target diseases for cell therapy due to their well-known healing impairments. Methods Cord blood-derived CD34+ cells were seeded in endothelial growth culture medium (EGM2) and ECFC colonies were obtained after 14–21 days. ECFC were exposed at pH 6.6 (preconditioned) or pH 7.4 (nonpreconditioned) for 6 h, and then pH was restored at 7.4. A model of type 2 diabetes induced by a high-fat and high-sucrose diet was developed in nude mice and hind limb ischemia was induced in these animals by femoral artery ligation. A P value
Published: 2018
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4. High-Energy and Very High-Energy Constraints from Log-Parabolic Spectral Models in Narrow-Line Seyfert 1 Galaxies

Author: Stefano Vercellone, Luigi Foschini, Patrizia Romano, Markus Böttcher, and Catherine Boisson
Subjects: narrow-line Seyfert 1 galaxies, gamma-ray rmission, relativistic jets, broad-line region, stochastic acceleration, Elementary particle physics, QC793-793.5
Abstract: Narrow-line Seyfert 1 galaxies (NLSy1s) are a well established class of γ -ray sources, showing the presence of a jet like the more common flat-spectrum radio quasars. The evidence of γ -ray emission poses the issue of the location of the γ -ray emitting zone and of the contribution of the γ - γ absorption within the broad-line region (BLR), since such objects have been detected by Fermi-LAT in the MeV-GeV energy range but not by imaging atmospheric Cherenkov telescopes beyond 100 GeV. We discuss how the spectral properties of three NLSy1s (SBS 0846+513, PMN J0948+0022, and PKS 1502+036) derived from the Fermi Large Area Telescope Fourth Source Catalog (4FGL) compared with theoretical models based on the observed properties of the BLR. In particular, we focus on the question on how simple power-law spectral models and log-parabolic ones could be disentangled in γ -ray narrow-line Seyfert 1 galaxies by means of current Fermi-LAT or future imaging atmospheric Cherenkov telescopes data. We found that the only possibility for a log-parabolic model to mimic a power-law model in the energy band above E ∼ 100 GeV is to have a very small value of the curvature parameter β ∼ 0.05 .
Published: 2020
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5. Osteoprotegerin Induces CD34+ Differentiation in Endothelial Progenitor Cells

Author: Catherine Boisson-Vidal, Zahia Benslimane-Ahmim, Anna Lokajczyk, Dominique Heymann, and David M. Smadja
Subjects: osteoprotegerin, endothelial progenitor cells, endothelial-colony forming cells, CD34+ cells, proliferation, Medicine (General), R5-920
Abstract: Endothelial progenitor cells (EPCs) are the main hypothetical cells that could give rise to vessels and in particular one subtype isolated from peripheral or cord bloods: endothelial colony forming cells (ECFCs). These ECFCs are clonogenic precursors committed to endothelial lineage and have robust vasculogenic properties. However, their low number and poor expansion properties when isolated from human adult bloods, currently limit their use as an autologous cell therapy product. We previously reported that osteoprotegerin (OPG), a well-characterized regulator of bone metabolism, contributes to ischemic tissue revascularization, tumor growth in vivo, and potentiates ECFCs proangiogenic properties through the secretion of SDF-1. The current study investigated the role of OPG in ECFCs differentiation and expansion from cord blood CD34+ cells. OPG increased the number of ECFCs after endothelial differentiation of CD34+ cells, enhancing the time of EPCs colonies initial appearance and the growth kinetic of endothelial cell progeny. OPG-exposed ECFCs expressed higher levels of CD34+ compared to control ECFCs. In conclusion, our findings provide novel insights into OPG in regulation of CD34+ progenitor cells. These results give new opportunities for ex vivo expansion of human ECFCs using OPG as a cell culture component for future ECFC product manufacture according to GMP.
Published: 2018
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6. Modeling the Broad-Band Emission from the Gamma-Ray Emitting Narrow-Line Seyfert-1 Galaxies 1H 0323+342 and B2 0954+25A

Author: Maialen Arrieta-Lobo, Catherine Boisson, and Andreas Zech
Subjects: AGN, quasar, NLSy1, blazar, gamma-ray, modeling, Astronomy, QB1-991, Geophysics. Cosmic physics, QC801-809
Abstract: Prior to the Fermi-LAT era, only two classes of Active Galactic Nuclei (AGN) were thought to harbor relativistic jets that radiate up to gamma-ray energies: blazars and radio galaxies. The detection of variable gamma-ray emission from Narrow Line Seyfert 1 (NLSy1) galaxies has put them on the spotlight as a new class of gamma-ray emitting AGN. In this respect, gamma-ray emitting NLSy1s seem to be situated between blazars (dominated by non-thermal emission) and Seyferts (accretion disc dominated). In this work, we model the Spectral Energy Distribution (SED) of two gamma-loud NLSy1s, 1H 0323+342 and B2 0954+25A, during quiescent and flaring episodes via a multi-component radiative model that features a relativistic jet and external photon fields from the torus, disc, corona and Broad Line Region (BLR). We find that the interpretation of the high-energy emission of jetted NLSy1s requires taking into account Inverse Compton emission from particles in the relativistic jet that interact with external photon fields. Minimal changes are applied to the model parameters to transition from average to flaring states. In this scenario, the observed variability is explained mainly by means of changes in the jet density and Doppler factor.
Published: 2017
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7. Fucoidan Stimulates Monocyte Migration via ERK/p38 Signaling Pathways and MMP9 Secretion

Author: Elene Sapharikas, Anna Lokajczyk, Anne-Marie Fischer, and Catherine Boisson-Vidal
Subjects: fucoidan, monocytes, critical limb ischemia, migration, Biology (General), QH301-705.5
Abstract: Critical limb ischemia (CLI) induces the secretion of paracrine signals, leading to monocyte recruitment and thereby contributing to the initiation of angiogenesis and tissue healing. We have previously demonstrated that fucoidan, an antithrombotic polysaccharide, promotes the formation of new blood vessels in a mouse model of hindlimb ischemia. We examined the effect of fucoidan on the capacity of peripheral blood monocytes to adhere and migrate. Monocytes negatively isolated with magnetic beads from peripheral blood of healthy donors were treated with fucoidan. Fucoidan induced a 1.5-fold increase in monocyte adhesion to gelatin (p < 0.05) and a five-fold increase in chemotaxis in Boyden chambers (p < 0.05). Fucoidan also enhanced migration 2.5-fold in a transmigration assay (p < 0.05). MMP9 activity in monocyte supernatants was significantly enhanced by fucoidan (p < 0.05). Finally, Western blot analysis of fucoidan-treated monocytes showed upregulation of ERK/p38 phosphorylation. Inhibition of ERK/p38 phosphorylation abrogated fucoidan enhancement of migration (p < 0.01). Fucoidan displays striking biological effects, notably promoting monocyte adhesion and migration. These effects involve the ERK and p38 pathways, and increased MMP9 activity. Fucoidan could improve critical limb ischemia by promoting monocyte recruitment.
Published: 2015
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8. Towards a Provenance Management System for Astronomical Observatories.

Author: Mathieu Servillat, François Bonnarel, Catherine Boisson, Mireille Louys, José Enrique Ruiz, and Michèle Sanguillon
Published: 2021
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9. The relativistic jet of the γ-ray emitting narrow-line Seyfert 1 galaxy PKS J1222+0413

Author: Daniel Kynoch, Hermine Landt, Martin J Ward, Chris Done, Catherine Boisson, Mislav Baloković, Emmanouil Angelakis, and Ioannis Myserlis
Published: 2019
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10. Modelling the variable emission states of γ-ray-emitting narrow-line Seyfert 1 galaxies

Author: Anna Luashvili, Catherine Boisson, Andreas Zech, Maialen Arrieta-Lobo, and Daniel Kynoch
Subjects: Space and Planetary Science, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: $\gamma$-ray-emitting narrow-line Seyfert 1 galaxies ($\gamma$-NLS1) constitute an intriguing small population of Active Galactic Nuclei with $\gamma$-ray emission resembling low power flat-spectrum radio quasars (FSRQ), but with differing physical properties. They are jetted, $\gamma$/radio-loud Seyfert galaxies, with relatively low black hole masses, accreting at exceptionally high, near-Eddington rates. Certain of these sources exhibit highly variable emission states on relatively short time scales, the physical origin of which remains elusive. In this work, varying emission states of two bona-fide NLS1s, 1H 0323+342 and PMN J0948+0022, and one little studied FSRQ/intermediate object, B2 0954+25A, are examined. For each source, we analyzed quasi-simultaneous multiwavelength data for different states of $\gamma$-ray activity and present the results of their broad-band emission modelling, taking into account all available physical constraints to limit the range of the model parameters. Two different scenarios are discussed, in the framework of a one-zone leptonic model, where the high energy emission is due to the inverse Compton scattering of the disc and broad line region (BLR) or torus photons by relativistic electrons within the jet. The transition from low to high state is well described by variations of the jet parameters, leaving the external photon fields unchanged. The parameterisation favours an emission scenario with particle injection on a stationary shock inside the jet. When considering all physical constraints, the disc & BLR scenario is preferred for all three sources. We use the multi-epoch modelling to characterize total jet powers and discuss the intrinsic nature of $\gamma$-NLS1 galaxies and FSRQs., Comment: Accepted for publication in MNRAS
Published: 2023

11. Using the virtual observatory to study the gamma-ray sky

Author: Paula Kornecki, Mathieu Servillat, Catherine Boisson, and Matthias Fuessling
Published: 2023

12. IVOA Provenance Data Model Version 1.0

Author: Mathieu Servillat, Kristin Riebe, Catherine Boisson, François Bonnarel, Anastasia Galkin, Mireille Louys, Markus Nullmeier, Nicolas Renault-Tinacci, Michèle Sanguillon, and Ole Streicher
Published: 2022

13. Detection of extended TeV emission around the Geminga pulsar with H.E.S.S

Author: Michael Punch, Christo Venter, Christian Stegmann, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, M. Hörbe, L. Mohrmann, Hassan Abdalla, Albert Seyffert, Michael Backes, Laenita Lorraine Oberholzer, Dieter Horns, K. Nakashima, Tim Holch, K. Bernloehr, Naomi Tsuji, Heinrich J. Völk, Regis Terrier, Carlo Romoli, Gerard Fontaine, Tadayuki Takahashi, M. Fuessling, Hester Schutte, S. Steinmassl, Samuel Timothy Spencer, Sami Caroff, Victor Doroshenko, Frank M. Rieger, Clemens Hoischen, A. A. Zdziarski, P. T. O'Brien, Markus Holler, Q. Remy, Felix Jankowsky, Hannah Dalgleish, German Hermann, Paul Morris, Anne Lemiere, E. Kasai, Louis Du Plessis, Johann van der Walt, Martin Tluczykont, Dan Parsons, Anna Barnacka, D. Malyshev, Nukri Komin, Tom Armstrong, Felix Aharonian, Gilles Maurin, J. F. Glicenstein, David Sanchez, Krzysztof Katarzynski, Victor Barbosa Martins, Ira Jung, C. Arcaro, Sebastian Panny, Gianluca Giavitto, Angel Noel, Bruno Khelifi, Alison Mitchell, Santiago Pita, Werner Hofmann, Gašper Kukec Mezek, Atreyee Sinha, Emma Ona-Wilhelmi, Jonathan Mackey, Carlo van Rensburg, Gerd Puehlhofer, Lei Sun, Laura Olivera-Nieto, Hambeleleni Ndiyavala, Floriane Cangemi, A. Yusafzai, C. Levy, Alexandre Marcowith, Felix Werner, Thomas Lohse, Hend Yassin, Anton Dmytriiev, Manuel Meyer, Arnaud Mares, Manami Sasaki, Mathieu Naurois, Catherine Boisson, Jhilik Majumdar, N. Zywucka, Sumari Hattingh, Takaaki Tanaka, Gavin Rowell, Hector Rueda Ricarte, Mathieu Bony, Oguzhan Anguener, C. Moore, Riaan Steenkamp, Richard White, Kirsty Feijen, Heike Prokoph, Thomas Bylund, Rowan Batzofin, Andreas Zmija, Dorit Glawion, Samuel Zouari, Tomasz Bulik, Robert Brose, Andrea Santangelo, Jacco Vink, Michal Ostrowski, Anna Luashvili, Jacques Muller, Malgorzata Curlo, Marion Spir-Jacob, M. Lemoine-Goumard, Lente Dreyer, David Huber, J.-P. Lenain, Matthieu Renaud, Amid Nayerhoda, Hugh Spackman, Michael Kreter, Justine Devin, Sabrina Casanova, Anu Kundu, Stefan Klepser, V. Sahakian, G. Peron, Alessandro Montanari, Garret Cotter, Vikas Joshi, Zhiqiu Huang, T. Chand, Lott Frans, D. A. Prokhorov, K. Kosack, Sylvia Zhu, P. J. Meintjes, David Berge, Yves Gallant, Lukasz Stawarz, Stefan Ohm, Halim Ashkar, Fabian Leuschner, Jason John Watson, Davit Zargaryan, Arache Djannati-Ataï, Johannes Schaefer, S. J. Fegan, Andreas Quirrenbach, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Stefan Funk, Alicja Wierzcholska, Guillem Marti'i-Devesa, P. Reichherzer, V. Poireau, Jimmy N.S. Shapopi, Jaqueline Catalano, Stefano Gabici, Ramin Marx, M. Panter, Michael Zacharias, Jim Hinton, Jean-Pierre Ernenwein, U. Katz, G. Lamanna, R. Konno, Isak Delberth Davids, Fabian Schüssler, A. Fiasson, Sabrina Einecke, Iryna Lypova, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Roberta Zanin, Emmanuel Moulin, Andrew Taylor, B. Rudak, Kathrin Egberts, Johannes Veh, J. Bolmont, Faical Ait-Benkhali, Kleopas Shiningayamwe, Jacek Niemiec, G. Vasileiadis, Monica Barnard, Yvonne Becherini, Denys Malyshev, Maria Haupt, Olaf Reimer, Edna Ruiz Velasco, Lenka Tomankova, Sébastien Le Stum, Thomas Murach, Christopher van Eldik, Rafal Moderski, Mohanraj Senniappan, Francois Brun, P. Vincent, Heiko Salzmann, Andreas Specovius, Yu Wun Wong, Vincent Marandon, Hannes Thiersen, Vardan Baghmanyan, Celine Armand, Dmitriy Kostunin, L. Giunti, Brian van Soelen, Thomas Tavernier, Markus Boettcher, Michelle Tsirou, M.-H. Grondin, Rachel Simoni, Anita Reimer, Constantin Steppa, Ullrich Schwanke, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Brian Reville, Connor Duffy, James Davies, R. J. Tuffs, B. Bi, Mischa Breuhaus, Pauline Chambery, Marek Jamrozy, Helene Sol, Paolo Marchegiani, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and H.E.S.S.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Astrophysics::High Energy Astrophysical Phenomena, Gamma rays, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, imaging, Astronomy, IACT, Cosmology, Tellurium compounds, Cherenkov counter, gamma ray: emission, Pulsar, HESS, Milagro, TeV, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, HAWC, Cosmic rays, Cherenkov radiation, pulsar
Abstract: Highly extended gamma-ray emission around the Geminga pulsar was discovered by Milagro and verified by HAWC. Despite many observations with Imaging Atmospheric Cherenkov Telescopes (IACTs), detection of gamma-ray emission on angular scales exceeding the IACT field-of-view has proven challenging. Recent developments in analysis techniques have enabled the detection of significant emission around Geminga in archival data with H.E.S.S.. In 2019, further data on the Geminga region were obtained with an adapted observation strategy. Following the announcement of the detection of significant TeV emission around Geminga in archival data, in this contribution we present the detection in an independent dataset. New analysis results will be presented, and emphasis given to the technical challenges involved in observations of highly extended gamma-ray emission with IACTs., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference
Published: 2022

14. Searching for VHE gamma-ray emission associated with IceCube neutrino alerts using FACT, H.E.S.S., MAGIC, and VERITAS

Author: Konstancja, Satalecka, Acciari, Victor A., Stefano, Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel, Artero, Katsuaki, Asano, Dominik, Baack, Ana, Babic, Andr('(e))s, Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana, Batkovi('(c)), Josefa Becerra Gonzalez, Wlodek, Bednarek, Lorenzo, Bellizzi, Elisa, Bernardini, Maria-Isabel, Bernardos, Alessio, Berti, Jürgen, Besenrieder, Wrijupan, Bhattacharyya, Ciro, Bigongiari, Adrian, Biland, Oscar, Blanch, Hendrik, Bökenkamp, Giacomo, Bonnoli, Zeljka, Bosnjak, Giovanni, Busetto, Roberto, Carosi, Giovanni, Ceribella, Matteo, Cerruti, Yating, Chai, Ashot, Chilingarian, Stefan, Cikota, Sidika Merve Colak, Eduardo, Colombo, Jose Luis Contreras, Juan, Cortina, Stefano, Covino, Giacomo D( extquotesingle)Amico, Valerio D( extquotesingle)Elia, Paolo Da Vela, Francesco, Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel, Delfino, Jordi, Delgado, Carlos Delgado Mendez, Davide, Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espi(~(n))eira, Dijana Dominis Prester, Alice, Donini, Daniela, Dorner, Michele, Doro, Dominik, Elsaesser, Vandad Fallah Ramazani, Alicia, Fattorini, Maria Victoria Fonseca, Lluis, Font, Christian, Fruck, Satoshi, Fukami, Yasushi, Fukazawa, Garc('(i))a L('(o))pez, Ramon J., Markus, Garczarczyk, Sargis, Gasparyan, Markus, Gaug, Giglietto, Nicola, Francesco, Giordano, Pawel, Gliwny, Nikola, Godinovic, David, Green, Jarred Gershon Green, Daniela, Hadasch, Alexander, Hahn, Lea, Heckmann, Javier, Herrera, John, Hoang, Dario, Hrupec, Moritz, Hütten, Tomohiro, Inada, Kazuma, Ishio, Yuki, Iwamura, Irene Jim('(e))nez Mart('(i))nez, Jenni, Jormanainen, L('(e))a, Jouvin, Marie, Karjalainen, Daniel, Kerszberg, Yukiho, Kobayashi, Hidetoshi, Kubo, Junko, Kushida, Alessandra, Lamastra, Damir, Lelas, Francesco, Leone, Elina, Lindfors, Lena, Linhoff, Saverio, Lombardi, Francesco, Longo, Ruben, Lopez-Coto, Marcos, L('(o))pez-Moya, Alicia, L('(o))pez-Oramas, Loporchio, Serena, Bernardo Machado de Oliveira Fraga, Camilla, Maggio, Pratik, Majumdar, Martin, Makariev, Manuela, Mallamaci, Galina, Maneva, Marina, Manganaro, Karl, Mannheim, Laura, Maraschi, Mos(`(e)), Mariotti, Manel, Martinez, Daniel, Mazin, Stefano, Menchiari, Simone, Mender, Sa( (s))a Mi('(c))anovi('(c)), Davide, Miceli, Tjark, Miener, Jose Miguel Miranda, Razmik, Mirzoyan, Edgar, Molina, Abelardo, Moralejo, Daniel, Morcuende, Victoria, Moreno, Elena, Moretti, Takeshi, Nakamori, Lara, Nava, Vitaly, Neustroev, Cosimo, Nigro, Kari, Nilsson, Kyoshi, Nishijima, Koji, Noda, Seiya, Nozaki, Yoshiki, Ohtani, Tomohiko, Oka, Jorge, Otero-Santos, Simona, Paiano, Michele, Palatiello, David, Paneque, Riccardo, Paoletti, Paredes, Josep M., Lovro, Pavleti('(c)), Pablo, Pe(~(n))il, Massimo, Persic, Marine, Pihet, Pier Giorgio Prada Moroni, Elisa, Prandini, Chaitanya, Priyadarshi, Ivica, Puljak, Wolfgang, Rhode, Marc, Rib('(o)), Javier, Rico, Chiara, Righi, Andrea, Rugliancich, Narek, Sahakyan, Takayuki, Saito, Shunsuke, Sakurai, Francesco Gabriele Saturni, Bernd, Schleicher, Kevin, Schmidt, Thomas, Schweizer, Julian, Sitarek, Iva, ( (S))nidari('(c)), Dorota, Sobczy('(n))ska, Alessia, Spolon, Antonio, Stamerra, Jelena Stri( (s))kovi('(c)), Derek, Strom, Marcel, Strzys, Yusuke, Suda, Tihomir, Suri('(c)), Mitsunari, Takahashi, Ryuji, Takeishi, Fabrizio, Tavecchio, Petar, Temnikov, Tomislav, Terzic, Masahiro, Teshima, Luca, Tosti, Stefano, Truzzi, Antonio, Tutone, Santiago, Ubach, Juliane van Scherpenberg, Gaia, Vanzo, Monica VAZQUEZ ACOSTA, Sofia, Ventura, Vassil, Verguilov, Carlo Francesco Vigorito, Vincenzo, Vitale, Ievgen, Vovk, Martin, Will, Carolin, Wunderlich, Tokonatsu, Yamamoto, Darko, Zari('(c)), Matteo, Balbo, Thomas, Bretz, Jens, Buss, Laura, Eisenberger, Dorothee, Hildebrand, Roman, Iotov, Adelina, Kalenski, Dominik, Neise, Maximilian, Noethe, Aleksander, Paravac, Vitalii, Sliusar, Roland, Walter, Rasha, Abbasi, Markus, Ackermann, Jenni, Adams, Juanan, Aguilar, Ahlers, M., Maryon, Ahrens, Cyril Martin Alispach, Antonio Augusto Alves Junior, Najia Moureen Binte Amin, Rui, An, Karen, Andeen, Tyler, Anderson, Gisela, Anton, Carlos, Arguelles, Yosuke, Ashida, Spencer, Axani, Xinhua, Bai, Aswathi Balagopal, V., Anastasia Maria Barbano, Barwick, S. W., Benjamin, Bastian, Vedant, Basu, Sebastian, Baur, Bay, R. C., Beatty, J. J., Becker, K. -H., Julia Becker Tjus, Chiara, Bellenghi, Segev, Benzvi, Berley, D., Besson, D. Z., Gary, Binder, Daniel, Bindig, Blaufuss, E., Summer, Blot, Matthias, Boddenberg, Federico, Bontempo, Jurgen, Borowka, Boser, S., Olga, Botner, Jakob, Bottcher, Etienne, Bourbeau, Federica, Bradascio, Braun, J., Stephanie, Bron, Jannes, Brostean-Kaiser, Sally-Ann, Browne, Alexander, Burgman, Ryan, Burley, Raffaela, Busse, Michael, Campana, Erin, Carnie-Bronca, Chujie, Chen, Dmitry, Chirkin, Koun, Choi, Bryanlee, Clark, Kenneth, Clark, Lew, Classen, Alan, Coleman, Gabriel, Collin, Conrad, J. M., Paul, Coppin, Pablo, Correa, Cowen, D. F., Cross, R., Christian, Dappen, Pranav, Dave, Catherine DE CLERCQ, James, Delaunay, Hans, Dembinski, Kunal, Deoskar, Sam De Ridder, Abhishek, Desai, Paolo, Desiati, Krijn de Vries, Gwenhaël de Wasseige, Meike De With, Tyce, Deyoung, Sukeerthi, Dharani, Alejandro, Diaz, Juan Carlos Diaz-Velez, Markus, Dittmer, Hrvoje, Dujmovic, Matt, Dunkman, Michael, Duvernois, Emily, Dvorak, Thomas, Ehrhardt, Philipp, Eller, Ralph, Engel, Hannah, Erpenbeck, John, Evans, Evenson, P. A., Kwok Lung Fan, Fazely, A. R., Sebastian, Fiedlschuster, Aaron, Fienberg, Kirill, Filimonov, Chad, Finley, Leander, Fischer, Derek, B Fox, Anna, Franckowiak, Elizabeth, Friedman, Alexander, Fritz, Philipp, Furst, Gaisser, T. K., Jay, Gallagher, Erik, Ganster, Alfonso, Garcia, Simone, Garrappa, Gerhardt, L., Ava, Ghadimi, Christian, Glaser, Theo, Glauch, Thorsten, Glusenkamp, Goldschmidt, A., Javier, Gonzalez, Sreetama, Goswami, Darren, Grant, Timoth('(e))e, Gr('(e))goire, Spencer, Griswold, Mehmet, Gunduz, Christoph, Günther, Christian, Haack, Allan, Hallgren, Halliday, R., Halve, L., Halzen, F., Martin Ha Minh, Kael, Hanson, John, Hardin, Harnisch, Alexander A., Andreas, Haungs, Simon, Hauser, Dustin, Hebecker, Helbing, K., Felix, Henningsen, Hettinger, Emma C., Stephanie, Hickford, Joshua, Hignight, Colton, Hill, Hill, G. C., Kara, Hoffman, Ruth, Hoffmann, Tobias, Hoinka, Benjamin, Hokanson-Fasig, Hoshina, K., Feifei, Huang, Matthias, Huber, Thomas, Huber, Klas, Hultqvist, Mirco, Hunnefeld, Raamis, Hussain, Seongjin, In, Nad(`(e))ge, Iovine, Aya, Ishihara, Matti, Jansson, George, Japaridze, Minjin, Jeong, Ben, Jones, Donghwa, Kang, Woosik, Kang, Xinyue, Kang, Alexander, Kappes, David, Kappesser, Timo, Karg, Martina, Karl, Karle, A., Katz, U., Kauer, M., Moritz, Kellermann, Kelley, J. L., Ali, Kheirandish, Ken( extquotesingle)ichi Kin, Thomas, Kintscher, Joanna, Kiryluk, Spencer, Klein, Ramesh, Koirala, Hermann, Kolanoski, Tomas, Kontrimas, Lutz, Kopke, Claudio, Kopper, Sandro, Kopper, Koskinen, D. J., Paras, Koundal, Michael, Kovacevich, Marek, Kowalski, Tetiana, Kozynets, Emma, Kun, Naoko, Kurahashi, Neha, Lad, Cristina Lagunas Gualda, Justin, Lanfranchi, Michael, J Larson, Frederik Hermann Lauber, Jeffrey, Lazar, Jiwoong, Lee, Kayla, Leonard, Agnieszka, Leszczy('(n))ska, Yijia, Li, Massimiliano, Lincetto, Qinrui, Liu, Maria, Liubarska, Elisa, Lohfink, Cristian Jesus Lozano Mariscal, Lu, Lu, Francesco, Lucarelli, Andrew, Ludwig, William, Luszczak, Yang, Lyu, Wing Yan Ma, James, Madsen, Kendall, Mahn, Yuya, Makino, Sarah, Mancina, Ioana Codrina Maris, Maruyama, Reina H., Mase, K., Thomas, Mcelroy, Frank, Mcnally, James Vincent Mead, Meagher, K., Andres, Medina, Maximilian, Meier, Stephan, Meighen-Berger, Jessie, Micallef, Daniela, Mockler, Teresa, Montaruli, Roger, Moore, Morse, R., Marjon, Moulai, Richard, Naab, Ryo, Nagai, Uwe, Naumann, Jannis, Necker, Le Viet Nguyen, Hans, Niederhausen, Mehr, Nisa, Sarah, Nowicki, Dave, Nygren, Anna Obertacke Pollmann, Marie, Oehler, Olivas, A., Erin O( extquotesingle)Sullivan, Hershal, Pandya, Daria, Pankova, Nahee, Park, Grant, Parker, Ek Narayan Paudel, Larissa, Paul, Carlos Perez de los Heros, Lilly, Peters, Saskia, Philippen, Damian, Pieloth, Sarah, Pieper, Martin, Pittermann, Pizzuto, A., Plum, M., Yuiry, Popovych, Alessio, Porcelli, Maria Prado Rodriguez, Buford Price, P., Brandom, Pries, Gerald, Przybylski, Christoph, Raab, Amirreza, Raissi, Mohamed, Rameez, Rawlins, K., Immacolata Carmen Rea, Abdul, Rehman, Ren('(e)), Reimann, Giovanni, Renzi, Elisa, Resconi, Simeon, Reusch, Mike, Richman, Benedikt, Riedel, Ella, Roberts, Sally, Robertson, Gerrit, Roellinghoff, Martin, Rongen, Carsten, Rott, Tim, Ruhe, Dirk, Ryckbosch, Devyn Rysewyk Cantu, Ibrahim, Safa, Julian, Saffer, Sebastian Sanchez Herrera, Alexander, Sandrock, Joakim, Sandroos, Marcos, Santander, Subir, Sarkar, Sourav, Sarkar, Maximilian Karl Scharf, Merlin, Schaufel, Harald, Schieler, Sebastian, Schindler, Schlunder, P., Torsten, Schmidt, Austin, Schneider, Judith, Schneider, Schröder, Frank G., Lisa Johanna Schumacher, Georg, Schwefer, Steve, Sclafani, Seckel, D., Surujhdeo, Seunarine, Ankur, Sharma, Shefali, Shefali, Manuel, Silva, Barbara, Skrzypek, Ben, Smithers, Robert, Snihur, Jan, Soedingrekso, Dennis, Soldin, Christian, Spannfellner, Glenn, Spiczak, Christian, Spiering, Juliana, Stachurska, Michael, Stamatikos, Stanev, T., Robert, Stein, Joeran, Stettner, Steuer, A., Stezelberger, T., Timo, Sturwald, Thomas, Stuttard, Sullivan, G. W., Taboada, I., Frederik, Tenholt, Samvel, Ter-Antonyan, Tilav, S., Franziska, Tischbein, Kirsten, Tollefson, Christoph, Tönnis, Simona, Toscano, Delia, Tosi, Alexander, Trettin, Maria, Tselengidou, Chunfai, Tung, Andrea, Turcati, Roxanne, Turcotte, Colin, Turley, Jean Pierre Twagirayezu, Bunheng, Ty, Martin Unland Elorrieta, Nora, Valtonen-Mattila, Justin, Vandenbroucke, Nick van Eijndhoven, David, Vannerom, Jakob van Santen, Stef, Verpoest, Matthias, Vraeghe, Walck, C., Timothyblake, Watson, Chris, Weaver, Philip, Weigel, Andreas, Weindl, Matthew, Weiss, Jan, Weldert, Chris, Wendt, Johannes, Werthebach, Mark, Weyrauch, Nathan, Whitehorn, Wiebusch, C. H., Dawn, Williams, Martin, Wolf, Kurt, Woschnagg, Gerrit, Wrede, Johan, Wulff, Xianwu, Xu, Yiqian, Xu, Juan Pablo Yanez, Yoshida, S., Shiqi, Yu, Tianlu, Yuan, Zelong, Zhang, Weidong, Jin, Hassan, Abdalla, Felix, Aharonian, Faical, Ait-Benkhali, Oguzhan, Anguener, Cornelia, Arcaro, Celine, Armand, Tom, Armstrong, Halim, Ashkar, Michael, Backes, Vardan, Baghmanyan, Victor Barbosa Martins, Anna, Barnacka, Monica, Barnard, Rowan, Batzofin, Yvonne, Becherini, David, Berge, Konrad, Bernlöhr, Baiyang, Bi, Markus, Boettcher, Catherine, Boisson, Julien, Bolmont, Mathieu de Bony, Mischa, Breuhaus, Robert, Brose, Francois, Brun, Tomasz, Bulik, Thomas, Bylund, Floriane, Cangemi, Sami, Caroff, Sabrina, Casanova, Jaqueline, Catalano, Pauline, Chambery, Tej Bahadur Chand, Andrew, Chen, Garret, Cotter, Malgorzata, Curlo, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James, Davies, Justine, Devin, Arache, Djannati-Ataï, Anton, Dmytriiev, Axel, Donath, Victor, Doroshenko, Lente, Dreyer, Louis Du Plessis, Connor, Duffy, Kathrin, Egberts, Sabrina, Einecke, Gabriel, Emery, Jean-Pierre, Ernenwein, Steven, Fegan, Kirsty, Feijen, Armand, Fiasson, Gaëtan Fichet de Clairfontaine, Gerard, Fontaine, Lott, Frans, Matthias, Fuessling, Stefan, Funk, Stefano, Gabici, Yves, Gallant, Shahede, Ghafourizade, Gianluca, Giavitto, Luca, Giunti, Dorit, Glawion, Jean-Francois, Glicenstein, Marie-H('(e))l(`(e))ne, Grondin, Sumari, Hattingh, Maria, Haupt, German, Hermann, Jim, Hinton, Werner, Hofmann, Clemens, Hoischen, Tim, Holch, Markus, Holler, Dieter, Horns, Zhiqiu, Huang, David, Huber, Mario, Hörbe, Marek, Jamrozy, Felix, Jankowsky, Vikas, Joshi, Ira, Jung, Eli, Kasai, Krzysztof, Katarzynski, Ul(`(i)), Katz, Dmitry, Khangulyan, Bruno, Khelifi, Stefan, Klepser, Wlodek, Kluzniak, Nukri, Komin, Ruslan, Konno, Karl, Kosack, Dmitriy, Kostunin, Michael, Kreter, Ga( (s))per Kukec Mezek, Anu, Kundu, Giovanni, Lamanna, S('(e))bastien Le Stum, Anne, Lemiere, Marianne, Lemoine-Goumard, Jean-Philippe, Lenain, Fabian, Leuschner, Christelle, Levy, Thomas, Lohse, Anna, Luashvili, Iryna, Lypova, Jonathan, Mackey, Jhilik, Majumdar, Denys, Malyshev, Dmitry, Malyshev, Vincent, Marandon, Paolo, Marchegiani, Alexandre, Marcowith, Arnaud, Mares, Guillem Marti( extquotesingle)i-Devesa, Ramin, Marx, Gilles, Maurin, Pieter, Meintjes, Manuel, Meyer, Alison, Mitchell, Rafal, Moderski, Lars, Mohrmann, Alessandro, Montanari, Chris, Moore, Paul, Morris, Emmanuel, Moulin, Jacques, Muller, Thomas, Murach, Kaori, Nakashima, Mathieu Naurois (de), Amid, Nayerhoda, Hambeleleni, Ndiyavala, Jacek, Niemiec, Angel, Noel, Paul O( extquotesingle)Brien, Laenita Lorraine Oberholzer, Stefan, Ohm, Laura, Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal, Ostrowski, Sebastian, Panny, Michael, Panter, Dan, Parsons, Giada, Peron, Santiago, Pita, Vincent, Poireau, Dmitry, Prokhorov, Heike, Prokoph, Gerd, Puehlhofer, Michael, Punch, Andreas, Quirrenbach, Patrick, Reichherzer, Anita, Reimer, Olaf, Reimer, Quentin, Remy, Matthieu, Renaud, Brian, Reville, Frank, Rieger, Carlo, Romoli, Gavin, Rowell, Bronislaw, Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan, Sahakian, Simon, Sailer, Heiko, Salzmann, David, Sanchez, Andrea, Santangelo, Manami, Sasaki, Johannes, Schaefer, Hester, Schutte, Ullrich, Schwanke, Fabian, Schüssler, Mohanraj, Senniappan, Albert, Seyffert, Shapopi, Jimmy N. S., Kleopas, Shiningayamwe, Rachel, Simoni, Atreyee, Sinha, Helene, Sol, Hugh, Spackman, Andreas, Specovius, Samuel Timothy Spencer, Marion, Spir-Jacob, Lukasz, Stawarz, Riaan, Steenkamp, Christian, Stegmann, Simon, Steinmassl, Constantin, Steppa, Lei, Sun, Tadayuki, Takahashi, Takaaki, Tanaka, Thomas, Tavernier, Andrew, Taylor, Regis, Terrier, Hannes, Thiersen, Charles, Thorpe-Morgan, Martin, Tluczykont, Lenka, Tomankova, Michelle, Tsirou, Naomi, Tsuji, Richard, Tuffs, Yasunobu, Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George, Vasileiadis, Johannes, Veh, Christo, Venter, Pascal, Vincent, Jacco, Vink, Völk, Heinrich J., Stefan, Wagner, Jason John Watson, Felix, Werner, Richard, White, Alicja, Wierzcholska, Yu Wun Wong, Hend, Yassin, Anke, Yusafzai, Michael, Zacharias, Roberta, Zanin, Davit, Zargaryan, Andrzej, Zdziarski, Andreas, Zech, Sylvia, Zhu, Andreas, Zmija, Samuel, Zouari, Natalia, Zywucka, The FACT Collaboration, The H.E.S.S. Collaboration, The IceCube Collaboration, The MAGIC Collaboration, The VERITAS Collaboration, and Współautorami artykułu są członkowie Magic Collaboration, IceCube Collaboration, FACT Collaboration, H.E.S.S. Collaboration, VERITAS Collaboration w liczbie 808
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Point source, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, IACT, Astrophysics, law.invention, High Energy Physics - Experiment, Telescope, High Energy Physics - Experiment (hep-ex), law, HESS - Abteilung Hinton, ddc:530, High Energy Physics::Experiment, MAGIC (telescope), Neutrino, Blazar, Astrophysics - High Energy Astrophysical Phenomena, Cherenkov radiation
Abstract: The realtime follow-up of neutrino events is a promising approach to search for astrophysical neutrino sources. It has so far provided compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 observed in coincidence with the high-energy neutrino IceCube-170922A detected by IceCube. The detection of very-high-energy gamma rays (VHE, $\mathrm{E} > 100\,\mathrm{GeV}$) from this source helped establish the coincidence and constrained the modeling of the blazar emission at the time of the IceCube event. The four major imaging atmospheric Cherenkov telescope arrays (IACTs) - FACT, H.E.S.S., MAGIC, and VERITAS - operate an active follow-up program of target-of-opportunity observations of neutrino alerts sent by IceCube. This program has two main components. One are the observations of known gamma-ray sources around which a cluster of candidate neutrino events has been identified by IceCube (Gamma-ray Follow-Up, GFU). Second one is the follow-up of single high-energy neutrino candidate events of potential astrophysical origin such as IceCube-170922A. GFU has been recently upgraded by IceCube in collaboration with the IACT groups. We present here recent results from the IACT follow-up programs of IceCube neutrino alerts and a description of the upgraded IceCube GFU system., Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06966 for all IceCube contributions. See arXiv:2108.05257 for all H.E.S.S. contributions
Published: 2022

15. FVIII regulates the molecular profile of endothelial cells: functional impact on the blood barrier and macrophage behavior

Author: Marie Cadé, Javier Muñoz-Garcia, Antoine Babuty, Louis Paré, Denis Cochonneau, Karim Fekir, Mathias Chatelais, Marie-Françoise Heymann, Anna Lokajczyk, Catherine Boisson-Vidal, and Dominique Heymann
Subjects: Pharmacology, Cell Membrane Permeability, Factor VIII, Proteome, Macrophages, Neovascularization, Physiologic, Cell Biology, Cellular and Molecular Neuroscience, Cell Movement, Cell Adhesion, Humans, Molecular Medicine, Endothelium, Vascular, Transcriptome, Molecular Biology
Abstract: Hemophilia A is an inherited X-linked recessive bleeding disorder caused by deficient activity of blood coagulation factor VIII (FVIII). In addition, hemophilia patients show associated diseases including osteopenia, altered inflammation and vascular fragility which may represent the consequence of recurrent bleeding or may be related to the direct FVIII deficiency. Nowadays, recombinant FVIII is proposed to treat hemophilia patients with no circulating FVIII inhibitor. Initially described as a coenzyme to factor IXa for initiating thrombin generation, there is emerging evidence that FVIII is involved in multiple biological systems, including bone, vascular and immune systems. The present study investigated: (i) the functional activities of recombinant human FVIII (rFVIII) on endothelial cells, and (ii) the impact of rFVIII activities on the functional interactions of human monocytes and endothelial cells. We then investigated whether rFVIII had a direct effect on the adhesion of monocytes to the endothelium under physiological flow conditions. We observed that direct biological activities for rFVIII in endothelial cells were characterized by: (i) a decrease in endothelial cell adhesion to the underlying extracellular matrix; (ii) regulation of the transcriptomic and protein profiles of endothelial cells; (iii) an increase in the vascular tubes formed and vascular permeability in vitro; and (iv) an increase in monocyte adhesion activated endothelium and transendothelial migration. By regulating vascular permeability plus leukocyte adhesion and transendothelial migration, the present work highlights new biological functions for FVIII.
Published: 2022

16. Limits on primordial black hole evaporation from H.E.S.S. observations

Author: Hannah Dalgleish, Michael Punch, Samuel Timothy Spencer, Stefan Ohm, Stefan Klepser, M. Fuessling, Constantin Steppa, Markus Holler, Q. Remy, Felix Jankowsky, Alessandro Montanari, Stefano Gabici, Felix Aharonian, Dan Parsons, S. Steinmassl, Sami Caroff, Gianluca Giavitto, Sumari Hattingh, Takaaki Tanaka, Ramin Marx, M. Panter, Laura Olivera-Nieto, A. Yusafzai, M.-H. Grondin, U. Katz, N. Zywucka, Alison Mitchell, Krzysztof Katarzynski, Catherine Boisson, J. Bolmont, Victor Barbosa Martins, Ullrich Schwanke, P. T. O'Brien, Jhilik Majumdar, Markus Boettcher, Faical Ait-Benkhali, Dieter Horns, C. Arcaro, Floriane Cangemi, V. Poireau, Jimmy N.S. Shapopi, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Clemens Hoischen, A. A. Zdziarski, Carlo van Rensburg, Albert Seyffert, Justine Devin, Gavin Rowell, G. Vasileiadis, Johann van der Walt, V. Sahakian, K. Nakashima, Sébastien Le Stum, Denys Malyshev, Regis Terrier, Mathieu Bony, Oguzhan Anguener, Tadayuki Takahashi, Victor Doroshenko, L. Giunti, E. Kasai, Vikas Joshi, Carlo Romoli, Yves Gallant, Frank M. Rieger, Atreyee Sinha, Kirsty Feijen, K. Bernloehr, Samuel Zouari, Andreas Zmija, Christian Stegmann, Michal Ostrowski, Stefan Wagner, J.-P. Lenain, Christo Venter, Hugh Spackman, S. J. Fegan, Andreas Zech, Jason John Watson, Heinrich J. Völk, Jean-Pierre Ernenwein, M. Lemoine-Goumard, Yasunobu Uchiyama, Matthieu Renaud, Mohanraj Senniappan, L. Mohrmann, Lukasz Stawarz, Anton Dmytriiev, German Hermann, Paul Morris, Johannes Veh, Brian Reville, Connor Duffy, James Davies, Stefan Funk, Alicja Wierzcholska, Michelle Tsirou, Michael Kreter, Anne Lemiere, Rachel Simoni, Andreas Quirrenbach, Manami Sasaki, R. J. Tuffs, B. Bi, Guillem Marti'i-Devesa, Jacek Niemiec, M. Hörbe, Andreas Specovius, Andrea Santangelo, Mischa Breuhaus, Pauline Chambery, Olaf Reimer, Michael Zacharias, Emma Ona-Wilhelmi, Martin Tluczykont, Yu Wun Wong, Robert Brose, Michael Backes, Francois Brun, Thomas Lohse, Marek Jamrozy, Jaqueline Catalano, T. Chand, Thomas Murach, Arache Djannati-Ataï, P. Reichherzer, Gašper Kukec Mezek, P. Vincent, Anita Reimer, Laenita Lorraine Oberholzer, Nukri Komin, G. Lamanna, Helene Sol, R. Konno, Monica Barnard, Anna Barnacka, Heiko Salzmann, G. Peron, Vincent Marandon, Hannes Thiersen, Andrew Taylor, Garret Cotter, Tim Holch, Dmitriy Kostunin, Hend Yassin, Isak Delberth Davids, Manuel Meyer, A. Fiasson, Tom Armstrong, Celine Armand, Johannes Schaefer, Roberta Zanin, Zhiqiu Huang, Paolo Marchegiani, Vardan Baghmanyan, Naomi Tsuji, Mathieu Naurois, D. A. Prokhorov, K. Kosack, Gerard Fontaine, Brian van Soelen, David Sanchez, Santiago Pita, Werner Hofmann, Hester Schutte, Hambeleleni Ndiyavala, Gilles Maurin, J. F. Glicenstein, Thomas Tavernier, Kleopas Shiningayamwe, Bruno Khelifi, Edna Ruiz Velasco, Lenka Tomankova, Sabrina Einecke, Iryna Lypova, Yvonne Becherini, Hassan Abdalla, C. Levy, Sylvia Zhu, P. J. Meintjes, David Berge, Richard White, Jacco Vink, Heike Prokoph, Marion Spir-Jacob, David Huber, Amid Nayerhoda, Maria Haupt, Sabrina Casanova, Halim Ashkar, Fabian Leuschner, B. Rudak, Kathrin Egberts, Christopher van Eldik, Rafal Moderski, Anna Luashvili, Lott Frans, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, Davit Zargaryan, Tomasz Bulik, Malgorzata Curlo, Lente Dreyer, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Riaan Steenkamp, Fabian Schüssler, Emmanuel Moulin, Thomas Bylund, Rowan Batzofin, Jacques Muller, Hector Rueda Ricarte, Louis Du Plessis, Anu Kundu, D. Malyshev, Ira Jung, Sebastian Panny, Gerd Puehlhofer, Lei Sun, Alexandre Marcowith, Felix Werner, and Arnaud Mares
Subjects: Physics, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, Gravitational collapse, Evaporation, Order (ring theory), Primordial black hole, Astrophysics, Radiation, Universe, media_common, Hawking radiation
Abstract: Primordial Black Holes are expected to be formed in the early Universe by the gravitational collapse of overdense regions, among other mechanisms. They are also expected to loose their mass over time by the Hawking radiation process. As the rates of this radiation increase with temperature, the PBH evaporation should result in a violent explosion. The current upper limits on explosion rates are on the order of 10$^{4}$ − 10$^{5}$pc$^{-3}$yr$^{-1}$. In this contribution we'll present the results of a search for TeV γ-ray burst within timescale of few seconds, using nearly 5000 hours of H.E.S.S. data. The search algorithm and statistical estimation strategy will be presented as well as cosmological implications of this measurement.
Published: 2022

17. Detection of new Extreme BL Lac objects with H.E.S.S. and Swift XRT

Author: Angel Priyana Noel, Hassan Abdalla, Felix Aharonian, Faical Ait-Benkhali, Oguzhan Anguener, Cornelia Arcaro, Celine Armand, Tom Armstrong, Halim Ashkar, Michael Backes, Vardan Baghmanyan, Victor Barbosa Martins, Anna Barnacka, Monica Barnard, Rowan William Batzofin, Yvonne Becherini, David Berge, Konrad Bernloehr, Baiyang Bi, Markus Böttcher, Catherine Boisson, Julien Bolmont, Mathieu Bony (de), Mischa Breuhaus, Robert Brose, Francois Brun, Tomasz Bulik, Thomas Bylund, Floriane Cangemi, Sami Caroff, Sabrina Casanova, Jaqueline Catalano, Pauline Chambery, Tej Bahadur Chand, Andrew Chen, Garret Cotter, Malgorzata Curlo, Hannah Dalgleish, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James Davies, Justine Devin, Arache Djannati-Ataï, Anton Dmytriev, Axel Donath, Victor Doroshenko, Lente Dreyer, Louis Du Plessis, Connor Duffy, Kathrin Egberts, Sabrina Einecke, Jean-Pierre ERNENWEIN, Steven Fegan, Kirsty Feijen, Armand Fiasson, Gaëtan Fichet de Clairfontaine, Gerard Fontaine, Lott Frans, Matthias Fuessling, Stefan Funk, Stefano Gabici, Yves Gallant, Gianluca Giavitto, Luca Giunti, Dorit Glawion, Jean-Francois Glicenstein, Marie-Hélène Grondin, Sumari Hattingh, Maria Haupt, German HERMANN, Jim Hinton, Werner Hofmann, Clemens Hoischen, Tim Holch, Markus Holler, Dieter Horns, Zhi-Qiu Huang, David Huber, Mario Hörbe, Marek Jamrozy, Felix Jankowsky, Vikas Joshi, Ira JUNG, Eli Kasai, Krzysztof Katarzynski, Ulì Katz, Dmitry Khangulyan, Bruno Khelifi, Stefan Klepser, Wlodek Kluzniak, Nukri Komin, Ruslan Konno, Karl Kosack, Dmitriy Kostunin, Michael Kreter, Gašper Kukec Mezek, Anu Kundu, Giovanni Lamanna, Sebastien Le Stum, Anne Lemiere, Marianne Lemoine-Goumard, Jean-Philippe Lenain, Fabian Leuschner, Christelle Levy, Thomas Lohse, Anna Luashvili, Iryna Lypova, Jonathan Mackey, Jhilik Majumdar, Denys Malyshev, Dmitry Malyshev, Vincent Marandon, Paolo Marchegiani, Alexandre Marcowith, Arnaud Mares, Guillem Martí-Devesa, Ramin Marx, Gilles Maurin, Pieter Meintjes, Manuel Meyer, Alison Mitchell, Rafal Moderski, Lars Mohrmann, Alessandro Montanari, Chris Moore, Paul Morris, Emmanuel Moulin, Jacques Muller, Thomas Murach, Kaori Nakashima, Mathieu Naurois (de), Amid Nayerhoda, Hambeleleni Davids, Jacek Niemiec, Paul O'Brien, Laenita Lorraine Oberholzer, Stefan Ohm, Laura Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal Ostrowski, Sebastian Panny, Michael Panter, Dan Parsons, Giada Peron, Santiago Pita, Vincent Poireau, Dmitry A Prokhorov, Heike Prokoph, Gerd PUEHLHOFER, Michael Punch, Andreas Quirrenbach, Patrick Reichherzer, Anita Reimer, Olaf Reimer, Quentin Remy, Matthieu Renaud, Brian Reville, Frank Rieger, Carlo Romoli, Gavin P Rowell, Bronislaw Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan Sahakian, Simon Sailer, Heiko Salzmann, David Sanchez, Andrea Santangelo, Manami Sasaki, Johannes Schaefer, Hester Schutte, Ullrich Schwanke, Fabian Schüssler, Mohanraj Senniappan, Albert Seyffert, Jimmy N.S. Shapopi, Kleopas Shiningayamwe, Rachel Simoni, Atreyee Sinha, Helene Sol, Hugh Spackman, Andreas Specovius, Samuel Timothy Spencer, Marion Spir-Jacob, Lukasz Stawarz, Riaan Steenkamp, Christian Stegmann, Simon Steinmassl, Constantin Steppa, Lei Sun, Tadayuki Takahashi, Takaaki Tanaka, Thomas Tavernier, Andrew Taylor, Regis Terrier, Hannes Thiersen, Charles Thorpe-Morgan, Martin Tluczykont, Lenka Tomankova, Michelle Tsirou, Naomi Tsuji, Richard Tuffs, Yasunobu Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George Vasileiadis, Johannes Veh, Christo Venter, Pascal Vincent, Jacco Vink, Heinrich J. Völk, Stefan Wagner, Jason John Watson, Felix Werner, Richard White, Alicja Wierzcholska, Yu Wun Wong, Hend Mahmoud Yassin, Anke Yusafzai, Michael Zacharias, Roberta Zanin, Davit Zargaryan, Andrzej Zdziarski, Andreas Zech, Sylvia Zhu, Andreas Zmija, Samuel Zouari, Natalia Żywucka, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), H.E.S.S., and Fermi-LAT
Subjects: accelerator, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, gamma ray: absorption, VHE, law.invention, blazar, X-ray, particle: acceleration, law, HESS, synchrotron, Radiative transfer, TeV, High Energy Stereoscopic System, 10. No inequality, Absorption (electromagnetic radiation), Blazar, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Range (particle radiation), energy: high, redshift, Redshift, Synchrotron, Particle acceleration, spectral, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Extreme high synchrotron peaked blazars (EHBLs) are amongst the most powerful accelerators found in nature. Usually the synchrotron peak frequency of an EHBL is above $10^{17}\,$Hz, i.e., lies in the range of medium to hard X-rays making them ideal sources to study particle acceleration and radiative processes. EHBL objects are commonly observed at energies beyond several TeV, making them also powerful probes of gamma-ray absorption in the intergalactic medium. During the last decade, several attempts have been made to increase the number of EHBL detected at TeV energies and probe their spectral characteristics. Here we report new detections of EHBLs in the TeV energy regime, each at a redshift of less than 0.2, by the High Energy Stereoscopic System (H.E.S.S.). Also, we report on X-ray observations of these EHBLs candidates with Swift XRT. In conjunction with the very high energy observations, this allows us to probe the radiation mechanisms and the underlying particle acceleration processes., Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021)
Published: 2022

18. H.E.S.S. ToO program on nearby core-collapse Supernovae : search for very-high energy γ-ray emission towards the SN candidate AT2019krl in M74

Author: German Hermann, Paul Morris, Tadayuki Takahashi, Victor Doroshenko, Ramin Marx, Marek Jamrozy, E. Kasai, Jean-Pierre Ernenwein, Helene Sol, M. Panter, Denys Malyshev, U. Katz, Stefan Klepser, Alessandro Montanari, Markus Boettcher, Jacek Niemiec, Johannes Veh, Olaf Reimer, Regis Terrier, Robert Brose, M.-H. Grondin, Paolo Marchegiani, Matthieu Renaud, Stefan Ohm, Faical Ait-Benkhali, Thomas Murach, Carlo Romoli, Frank M. Rieger, Constantin Steppa, T. Chand, Laura Olivera-Nieto, Mohanraj Senniappan, G. Peron, Stefano Gabici, A. Yusafzai, Garret Cotter, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, Ullrich Schwanke, Johannes Schaefer, Sébastien Le Stum, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Arache Djannati-Ataï, Hannah Dalgleish, P. Reichherzer, Santiago Pita, Justine Devin, Hambeleleni Ndiyavala, Martin Tluczykont, Maria Haupt, J. Bolmont, G. Lamanna, M. Hörbe, Albert Seyffert, Isak Delberth Davids, A. Fiasson, Rachel Simoni, Roberta Zanin, P. T. O'Brien, Samuel Timothy Spencer, Brian Reville, Connor Duffy, C. Levy, James Davies, Dmitriy Kostunin, Gašper Kukec Mezek, Michal Ostrowski, Michael Backes, R. J. Tuffs, B. Bi, J.-P. Lenain, Jaqueline Catalano, Hugh Spackman, Dan Parsons, Halim Ashkar, Fabian Leuschner, Atreyee Sinha, Mathieu Bony, Oguzhan Anguener, S. J. Fegan, Brian van Soelen, N. Zywucka, Mischa Breuhaus, Pauline Chambery, Anton Dmytriiev, Laenita Lorraine Oberholzer, K. Nakashima, Christo Venter, Hend Yassin, Tim Holch, Kirsty Feijen, M. Fuessling, R. Konno, Manami Sasaki, Anna Barnacka, Markus Holler, Q. Remy, Felix Jankowsky, Manuel Meyer, Francois Brun, Andrew Taylor, Vikas Joshi, K. Bernloehr, P. Vincent, Anita Reimer, Krzysztof Katarzynski, Naomi Tsuji, Stefan Funk, Andrea Santangelo, Alicja Wierzcholska, Mathieu Naurois, Thomas Tavernier, Catherine Boisson, Floriane Cangemi, Gerard Fontaine, Anne Lemiere, Felix Aharonian, B. Rudak, V. Poireau, Kathrin Egberts, Jimmy N.S. Shapopi, S. Steinmassl, Sami Caroff, Heiko Salzmann, Hester Schutte, Jhilik Majumdar, Heinrich J. Völk, Andreas Specovius, Lukasz Stawarz, G. Vasileiadis, Richard White, Victor Barbosa Martins, Andreas Zmija, Jacco Vink, M. Lemoine-Goumard, Yu Wun Wong, Alison Mitchell, Jason John Watson, Celine Armand, David Huber, Andreas Quirrenbach, Sabrina Casanova, Emma Ona-Wilhelmi, Michael Kreter, Vincent Marandon, Hannes Thiersen, Guillem Marti'i-Devesa, Nukri Komin, Tom Armstrong, L. Giunti, Vardan Baghmanyan, Michael Zacharias, Christian Stegmann, Thomas Lohse, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, L. Mohrmann, Carlo van Rensburg, C. Arcaro, Christopher van Eldik, Samuel Zouari, Rafal Moderski, V. Sahakian, David Sanchez, Gavin Rowell, Michelle Tsirou, Yves Gallant, Kleopas Shiningayamwe, Werner Hofmann, Sabrina Einecke, Edna Ruiz Velasco, Iryna Lypova, Yvonne Becherini, Lenka Tomankova, Heike Prokoph, Monica Barnard, Marion Spir-Jacob, Amid Nayerhoda, Gilles Maurin, J. F. Glicenstein, Sylvia Zhu, P. J. Meintjes, David Berge, Bruno Khelifi, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Hassan Abdalla, Davit Zargaryan, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Fabian Schüssler, Emmanuel Moulin, Gianluca Giavitto, Ira Jung, Sebastian Panny, Louis Du Plessis, Sumari Hattingh, Gerd Puehlhofer, Lei Sun, Thomas Bylund, Rowan Batzofin, Takaaki Tanaka, Alexandre Marcowith, Felix Werner, Jacques Muller, Anna Luashvili, Stuart Ryder, Lott Frans, Arnaud Mares, Hector Rueda Ricarte, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, D. Malyshev, Tomasz Bulik, Riaan Steenkamp, Malgorzata Curlo, Lente Dreyer, Anu Kundu, Michael Punch, Dieter Horns, Clemens Hoischen, A. A. Zdziarski, and Johann van der Walt
Subjects: Core (optical fiber), Physics, Supernova, High energy, Gamma ray, Collapse (topology), Astrophysics
Abstract: While the youngest known supernova remnants (SNRs), such as Cassiopeia A (Cas A), have been proven to be able to accelerate cosmic rays (CRs) only up to ∼ 10$^{14}$ eV at their present evolutionary stages, recent studies have shown that particle energies larger than a few PeV (10$^{15}$ eV) could be reached during the early stages of a core-collapse Supernova (cc-SN), when the high-velocity forward shock expands into the dense circumstellar medium (CSM) shaped by the stellar progenitor wind. Such environments, in particular the type IIn SNe whose progenitors may exhibit mass loss rates as high as 10$^{-2}$ M$_{\bigodot}$ yr$^{-1}$, could thus lead to γ-ray emission from $\pi ^{0}$ decay in hadronic interactions, potentially detectable with current Cherenkov telescopes at very-high energies. Such a detection would provide direct evidence for efficient acceleration of CR protons/nuclei in supernovae, and hence new insights on the long-standing issue of the origin of Galactic Cosmic Rays. In that context, the High Energy Stereoscopic System (H.E.S.S.) has been carrying out a Target of Opportunity program since 2016 to search for such an early very-high-energy γ-ray emission towards nearby core-collapse supernovae and supernova candidates (up to ∼ 10 Mpc), within a few weeks after discovery. After giving an overview of this H.E.S.S. Target of Opportunity program, we present the results obtained from the July 2019 observations towards the transient AT2019krl, originally classified as a type IIn supernova, which occurred in the galaxy M74 at ∼ 9.8 Mpc. Although its nature still remains unclear, the derived H.E.S.S. constraints on this transient are placed in the general context of the expected VHE γ-ray emission from core-collapse supernovae.
Published: 2022

19. FAIR high level data for Cherenkov astronomy

Author: Mathieu Servillat, Catherine Boisson, Matthias Fuessling, Bruno Khélifi, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), CTAO gGmbH, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Computer and information sciences, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [INFO.INFO-IT]Computer Science [cs]/Information Theory [cs.IT], Computer Science - Information Theory, Information Theory (cs.IT), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract: International audience; We highlight here several solutions developed to make high-level Cherenkov data FAIR: Findable, Accessible, Interoperable and Reusable. The first three FAIR principles may be ensured by properly indexing the data and using community standards, protocols and services, for example provided by the International Virtual Observatory Alliance (IVOA). However, the reusability principle is particularly subtle as the question of trust is raised. Provenance information, that describes the data origin and all transformations performed, is essential to ensure this trust, and it should come with the proper granularity and level of details. We developed a prototype platform to make the first H.E.S.S. public test data findable and accessible through the Virtual Observatory (VO). The exposed high-level data follows the gamma-ray astronomy data format (GADF) proposed as a community standard to ensure wider interoperability. We also designed a provenance management system in connection with the development of pipelines and analysis tools for CTA (ctapipe and gammapy), in order to collect rich and detailed provenance information, as recommended by the FAIR reusability principle. The prototype platform thus implements the main functionalities of a science gateway, including data search and access, online processing, and traceability of the various actions performed by a user.
Published: 2021

20. Towards a Provenance Management System for Astronomical Observatories

Author: Mireille Louys, Catherine Boisson, José Enrique Ruiz, François Bonnarel, M. Servillat, Michèle Sanguillon, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), European Commission, Institut national des sciences de l'Univers (France), l'Observatoire de Paris, and Paris Astronomical Data Centre
Subjects: FOS: Computer and information sciences, Data processing, Provenance, Computer science, Information Theory (cs.IT), Astronomy, Computer Science - Information Theory, FOS: Physical sciences, Virtual observatory, Data science, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Data model, [INFO.INFO-IT]Computer Science [cs]/Information Theory [cs.IT], Management system, Use case, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: Provenance and Annotation of Data and Processes (2021).--8th and 9th International Provenance and Annotation Workshop, IPAW 2020 + IPAW 2021, Virtual Event, July 19–22, 2021, Proceedings.--Part of the Lecture Notes in Computer Science book series (LNCS, volume 11017).-- Part of the Lecture Notes in Computer Science book series (LNCS, volume 12839). Part of the Lecture Notes in Computer Science book series (LNCS, volume 12839). Also part of the Information Systems and Applications, incl. Internet/Web, and HCI book sub series (LNISA, volume 12839), We present here a provenance management system adapted to astronomical projects needs. We collected use cases from various astronomy projects and defined a data model in the ecosystem developed by the IVOA (International Virtual Observatory Alliance). From those use cases, we observed that some projects already have data collections generated and archived, from which the provenance has to be extracted (provenance “on top”), and some projects are building complex pipelines that automatically capture provenance information during the data processing (capture “inside”). Different tools and prototypes have been developed and tested to capture, store, access and visualize the provenance information, which participate to the shaping of a full provenance management system able to handle detailed provenance information. © 2021, Springer Nature Switzerland AG., We acknowledge support from the ESCAPE project funded by the EU Horizon 2020 research and innovation program (Grant Agreement n°824064). Additional funding was provided by the INSU (Action Spécifique Observatoire Virtuel, ASOV), the Action Fédératrice CTA at the Observatoire de Paris and the Paris Astronomical Data Centre (PADC).
Published: 2021

21. TeV Emission of Galactic Plane Sources with HAWC and H.E.S.S

Author: Nicola Omodei, Sebastian Panny, A. Sandoval, Q. Piel, S. Raab, Arturo Iriarte, Kirsty Feijen, R. D. Parsons, Michael Newbold, J. Zorn, Michael Schneider, Fernando Garfias, D. Huber, Christo Venter, Jacek Niemiec, Arnaud Mares, Frank M. Rieger, Thomas Weisgarber, A. Dmytriiev, Olaf Reimer, A. Zech, E. Ruiz-Velasco, Thomas Bylund, Y. A. Gallant, David Sánchez, R. López-Coto, Jorge Cotzomi, Jacques Muller, H. León Vargas, Alison Peisker, Justine Devin, Thomas Murach, P. Morris, Harm Schoorlemmer, Jonathan Mackey, Andrea Albert, Samuel Zouari, Pascal Vincent, M. Zacharias, Stefan Ohm, S. Pita, Tadayuki Takahashi, Gilgamesh Luis-Raya, A. Yusafzai, Andreas Quirrenbach, Samuel Timothy Spencer, Stefano Gabici, Regis Terrier, Victor Doroshenko, L. Nellen, Włodek Kluźniak, R. Noriega-Papaqui, E. Kasai, C. Moore, L. Oakes, J. Bolmont, Michal Ostrowski, J.-P. Lenain, Pooja Surajbali, William H. Lee, L. Olivera-Nieto, E. Moulin, Tomasz Bulik, Rhiannon Turner, Lente Dreyer, O. Martinez, Stefan Klepser, Alessandro Montanari, D. J. van der Walt, Fernando Ureña-Mena, J. P. Harding, César Alvarez, Michael DuVernois, A.M. Taylor, J. C. Arteaga-Velézquez, Connor Duffy, Davit Zargaryan, R. J. White, Stefan Funk, Alicja Wierzcholska, Dmitriy Kostunin, J. Damascene Mbarubucyeye, R. Rauth, Maria Magdalena González, Kristi Engel, A. Galván-Gámez, Christoph Deil, Krzysztof Katarzynski, F. Eichhorn, Mohanraj Senniappan, E. Moreno, Michael Punch, Axel Donath, B. Hona, A. W. Chen, S. Steinmassl, Sami Caroff, Domenico Tiziani, D. Malyshev, Catherine Boisson, M. Panter, Mora Durocher, U. Katz, Pedro Miranda-Romagnoli, C. Arcaro, H. Zhou, Michael Backes, S. Coutiño de León, Ernesto Belmont-Moreno, M. de Bony de Lavergne, R. Brose, Petra Hüntemeyer, C. Levy, Francois Brun, R. J. Tuffs, B. Bi, Andreas Specovius, Joachim Hahn, K. P. Arunbabu, Riaan Steenkamp, Gavin Rowell, P. Reichherzer, James E. M. Watson, M. Bryan, E. de Oña Wilhelmi, Łukasz Stawarz, C. van Rensburg, Pierre Brun, Brenda Dingus, V. Marandon, J. A. Morales-Soto, M. Büchele, H. Prokoph, C. De León, A. Marcowith, V. Baghmanyan, J. Schäfer, Nu. Komin, Tim Holch, Q. Remy, H. M. Schutte, Isak Delberth Davids, A. Fiasson, Jean-Pierre Ernenwein, Hassan Abdalla, S. Hernandez, Jim Hinton, V. Sahakian, E. De la Fuente, F. Werner, Mischa Breuhaus, Luis Villaseñor, Yu Wun Wong, Hambeleleni Ndiyavala, D. Avila Rojas, G. Lamanna, K. S. Caballero-Mora, Roberta Zanin, G. Emery, Halim Ashkar, Fabian Leuschner, Heiko Salzmann, A. S. Seyffert, Kwok Lung Fan, M. Hörbe, T. Tavernier, Nissim Illich Fraija, P. T. O'Brien, Johannes Veh, S. Sailer, Dmitry Khangulyan, Gilles Maurin, S. J. Fegan, A. Djannati-Ataï, D. Jankowsky, J. Dyks, Celine Armand, M. Füßling, R. Marx, Dieter Horns, M. Tluczykont, F. Ait Benkhali, J. F. Glicenstein, M. U. Nisa, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A. Jardin-Blicq, E. O. Angüner, R. Diaz Hernandez, N. Shafi, Natalia Żywucka, M. de Naurois, Andrea Santangelo, K. Malone, Gwenael Giacinti, L. Sun, M.-H. Grondin, D. Garcia, M. Seglar-Arroyo, B. Khélifi, A. J. Smith, T. Capistrán, B. van Soelen, G. Hermann, Anna Barnacka, D. Gottschall, Anne Lemiere, B. Rudak, Markus Böttcher, K. Tollefson, Jhilik Majumdar, Helene Sol, T. Chand, C. Brisbois, Andreas Zmija, Tom Armstrong, Elijah Willox, Carlo Romoli, Alison Mitchell, R. Torres-Escobedo, Atreyee Sinha, Manuel Meyer, I. Martinez-Castellanos, Zorawar Wadiasingh, A. Priyana Noel, V. Barbosa Martins, C. van Eldik, M. Lemoine-Goumard, M. Tsirou, Michael Kreter, Anna Lia Longinotti, F. Schüssler, Dezhi Huang, Jose Andres Garcia-Gonzalez, Werner Hofmann, Monica Barnard, Juan Carlos Diaz-Velez, V. Poireau, Jimmy N.S. Shapopi, K. Nakashima, José Serna-Franco, G. Peron, Garret Cotter, Jacco Vink, A. Carraminana, Umberto Cotti, Jim Davies, M. A. Kastendieck, Thomas Lohse, K. Kosack, Paolo Marchegiani, Konrad Bernlöhr, Heinrich J. Völk, Sabrina Casanova, Catalina Espinoza, M. Renaud, D. Berge, G. Vasileiadis, F. Salesa Greus, I. Jung-Richardt, Kleopas Shiningayamwe, Gilles Fontaine, J. T. Linnemann, Lenka Tomankova, M. Mostafá, G. Fichet de Clairfontaine, R. Konno, Gianluca Giavitto, V. Joshi, B. Peyaud, G. Pühlhofer, J. A. Goodman, H. Odaka, A. Reimer, R. W. Ellsworth, R. W. Springer, M. Curyło, F. Hueyotl-Zahuantitla, E. G. Pérez-Pérez, Y. Pérez Araujo, A. Nayerhoda, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, David Kieda, L. Mohrmann, Misao Sasaki, Markus Holler, Felix Jankowsky, Felix Aharonian, D. Glawion, Jesús Martínez-Castro, Segev BenZvi, Constantin Steppa, L. Giunti, D. A. Prokhorov, Ullrich Schwanke, L. Rinchiuso, J. A. Matthews, Ibrahim Torres, Rachel Simoni, A. Carosi, K. Egberts, S. Chandra, Ruben Alfaro, Sabrina Einecke, Iryna Lypova, Daniel Rosa-Gonzalez, Yvonne Becherini, M. Fernández Alonso, L. Dirson, G. Martí-Devesa, C. Trichard, Sylvia Zhu, P. J. Meintjes, J. H. E. Thiersen, Marion Spir-Jacob, Maria Haupt, C. D. Rho, Rafal Moderski, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Collaboration, H.E.S.S., and Collaboration, HAWC
Subjects: High-energy astronomy, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, IACT, Field of view, 030226 pharmacology & pharmacy, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Observatory, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, media_common, Physics, [PHYS]Physics [physics], Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Galactic plane, Space and Planetary Science, Sky, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], High energy astrophysics
Abstract: International audience; The High Altitude Water Cherenkov (HAWC) observatory and the High Energy Stereoscopic System (H.E.S.S.) are two leading instruments in the ground-based very-high-energy γ-ray domain. HAWC employs the water Cherenkov detection (WCD) technique, while H.E.S.S. is an array of Imaging Atmospheric Cherenkov Telescopes (IACTs). The two facilities therefore differ in multiple aspects, including their observation strategy, the size of their field of view, and their angular resolution, leading to different analysis approaches. Until now, it has been unclear if the results of observations by both types of instruments are consistent: several of the recently discovered HAWC sources have been followed up by IACTs, resulting in a confirmed detection only in a minority of cases. With this paper, we go further and try to resolve the tensions between previous results by performing a new analysis of the H.E.S.S. Galactic plane survey data, applying an analysis technique comparable between H.E.S.S. and HAWC. Events above 1 TeV are selected for both data sets, the point-spread function of H.E.S.S. is broadened to approach that of HAWC, and a similar background estimation method is used. This is the first detailed comparison of the Galactic plane observed by both instruments. H.E.S.S. can confirm the γ-ray emission of four HAWC sources among seven previously undetected by IACTs, while the three others have measured fluxes below the sensitivity of the H.E.S.S. data set. Remaining differences in the overall γ-ray flux can be explained by the systematic uncertainties. Therefore, we confirm a consistent view of the γ-ray sky between WCD and IACT techniques.
Published: 2021

22. Is PKS 0625-354 another variable TeV active galactic nucleus?

Author: Halim Ashkar, Fabian Leuschner, Gilles Maurin, Riaan Steenkamp, J. F. Glicenstein, Heike Prokoph, Bruno Khelifi, Floriane Cangemi, Michael Punch, Gianluca Giavitto, Anna Luashvili, Lott Frans, Sumari Hattingh, Martin Tluczykont, Marek Jamrozy, Sabrina Einecke, Takaaki Tanaka, Iryna Lypova, Marion Spir-Jacob, Yvonne Becherini, Helene Sol, Rachel Simoni, Davit Zargaryan, Hannah Dalgleish, Jim Hinton, Gašper Kukec Mezek, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Andreas Zmija, Amid Nayerhoda, M. Lemoine-Goumard, Stefan Klepser, Alessandro Montanari, C. Arcaro, S. J. Fegan, Anu Kundu, B. Rudak, T. Chand, Hend Yassin, Michael Kreter, Paolo Marchegiani, Tadayuki Takahashi, Dmitriy Kostunin, Mathieu Bony, Oguzhan Anguener, Fabian Schüssler, Manuel Meyer, Markus Boettcher, Gavin Rowell, Kathrin Egberts, Maria Haupt, Victor Doroshenko, Emmanuel Moulin, Ira Jung, Brian van Soelen, Sebastian Panny, Mathieu Naurois, E. Kasai, Kirsty Feijen, Samuel Timothy Spencer, Dieter Horns, Vikas Joshi, Thomas Tavernier, Johannes Schaefer, Gerd Puehlhofer, Lei Sun, Constantin Steppa, Jacek Niemiec, Hassan Abdalla, Albert Seyffert, Olaf Reimer, Christian Stegmann, Stefan Wagner, Andreas Zech, Alexandre Marcowith, Regis Terrier, Felix Werner, Yasunobu Uchiyama, K. Nakashima, K. Bernloehr, Carlo Romoli, Hector Rueda Ricarte, Lukasz Stawarz, Frank M. Rieger, Thomas Murach, Kleopas Shiningayamwe, Clemens Hoischen, A. A. Zdziarski, Christopher van Eldik, N. Zywucka, Jaqueline Catalano, L. Mohrmann, Monica Barnard, Rafal Moderski, Heinrich J. Völk, Arnaud Mares, Ullrich Schwanke, Stefan Ohm, Thomas Bylund, Rowan Batzofin, Anita Reimer, Andreas Quirrenbach, Edna Ruiz Velasco, Johann van der Walt, Jhilik Majumdar, Guillem Marti'i-Devesa, R. Konno, Jacques Muller, Dan Parsons, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Lenka Tomankova, Stefano Gabici, Andrew Taylor, Michael Zacharias, Christo Venter, Sylvia Zhu, P. J. Meintjes, David Berge, M. Hörbe, Michael Backes, Robert Brose, V. Poireau, Jimmy N.S. Shapopi, V. Sahakian, Krzysztof Katarzynski, Brian Reville, Connor Duffy, Laenita Lorraine Oberholzer, Tim Holch, Anton Dmytriiev, M. Fuessling, Manami Sasaki, G. Vasileiadis, Catherine Boisson, Arache Djannati-Ataï, P. Reichherzer, J. Bolmont, Jason John Watson, D. Malyshev, Andrea Santangelo, Naomi Tsuji, Matthieu Renaud, Denys Malyshev, Isak Delberth Davids, G. Lamanna, James Davies, A. Fiasson, Roberta Zanin, Yves Gallant, S. Steinmassl, Sami Caroff, R. J. Tuffs, Gerard Fontaine, B. Bi, Santiago Pita, Hambeleleni Ndiyavala, Hester Schutte, Justine Devin, Mohanraj Senniappan, C. Levy, Mischa Breuhaus, Pauline Chambery, Andreas Specovius, Jean-Pierre Ernenwein, Yu Wun Wong, Johannes Veh, Vincent Marandon, Hannes Thiersen, Vardan Baghmanyan, Markus Holler, Q. Remy, Felix Jankowsky, Richard White, Felix Aharonian, Jacco Vink, Alison Mitchell, David Huber, Sabrina Casanova, Louis Du Plessis, Angel Noel, Jonathan Mackey, Anna Barnacka, C. Moore, Victor Barbosa Martins, Dorit Glawion, Carlo van Rensburg, Anne Lemiere, Tomasz Bulik, Malgorzata Curlo, Emma Ona-Wilhelmi, Samuel Zouari, Thomas Lohse, Lente Dreyer, Michal Ostrowski, J.-P. Lenain, Hugh Spackman, Stefan Funk, Alicja Wierzcholska, Ramin Marx, M. Panter, U. Katz, Faical Ait-Benkhali, G. Peron, Garret Cotter, Sébastien Le Stum, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, P. T. O'Brien, Atreyee Sinha, Laura Olivera-Nieto, A. Yusafzai, Nukri Komin, Tom Armstrong, David Sanchez, Werner Hofmann, L. Giunti, Michelle Tsirou, Francois Brun, P. Vincent, Heiko Salzmann, Celine Armand, M.-H. Grondin, German Hermann, and Paul Morris
Subjects: Physics, Brightness, Active galactic nucleus, Astrophysics::High Energy Astrophysical Phenomena, Flux, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Viewing angle, Variable (computer science), symbols.namesake, symbols, Spectral energy distribution, Blazar, Doppler effect, Astrophysics::Galaxy Astrophysics
Abstract: The majority of the active galactic nuclei (AGN) detected at very-high-energies above 100 GeV belong to the class of blazars with a small angle between the jet-axis and the line-of-sight. Only about 10 percent of the gamma-ray AGN are objects with a larger viewing angle resulting in a smaller Doppler boosting of the emission. Originally, it was believed that gamma-ray emission can only be observed from blazars and those are variable in its brightness. Instead, the last years have shown that non-blazar active galaxies also show a fascinating variability behaviour which provide important new insights into the physical processes responsible for the gamma-ray production and especially for flaring events. Here, we report on the observation of gamma-ray variability of the active galaxy PKS 0625−354 detected with the H.E.S.S. telescopes in November 2018. The classification of PKS 0625−354 is a still matter of debate. The H.E.S.S. measurements were performed as part of a flux observing program and showed in the first night of the observation a detection of the object with > 5σ. A denser observation campaign followed for the next nine nights resulting in a decrease of the gamma-ray flux. Those observations were accompanied with Swift in the X-ray and UV/optical band allowing for the reconstruction of a multi-band broad-band spectral energy distribution. We will discuss the implications of the gamma-ray variability of the object.
Published: 2021

23. Search for dark matter annihilation towards the inner Milky Way halo with the H.E.S.S. Inner Galaxy Survey

Author: Clemens Hoischen, A. A. Zdziarski, Robert Brose, Johann van der Walt, Halim Ashkar, Fabian Leuschner, Stefan Ohm, L. Giunti, Albert Seyffert, Davit Zargaryan, Stefan Klepser, Alessandro Montanari, K. Nakashima, Gaëtan Fichet de Clairfontaine, Sabrina Einecke, Axel Donath, A. W. Chen, Iryna Lypova, K. Bernloehr, Heinrich J. Völk, Yvonne Becherini, Stefano Gabici, Michelle Tsirou, Anna Luashvili, Vikas Joshi, J. Bolmont, Fabian Schüssler, M.-H. Grondin, Emmanuel Moulin, Andreas Specovius, Kleopas Shiningayamwe, Anne Lemiere, B. Rudak, Lott Frans, Michael Punch, Edna Ruiz Velasco, Sylvia Zhu, P. J. Meintjes, David Berge, Michael Backes, Matthieu Renaud, German Hermann, Paul Morris, Kathrin Egberts, Constantin Steppa, Tadayuki Takahashi, Laenita Lorraine Oberholzer, Tim Holch, Lukasz Stawarz, Louis Du Plessis, Naomi Tsuji, V. Poireau, Jimmy N.S. Shapopi, Victor Doroshenko, Yu Wun Wong, Emma Ona-Wilhelmi, Riaan Steenkamp, E. Kasai, G. Lamanna, Ullrich Schwanke, Gerard Fontaine, Jim Hinton, Victor Barbosa Martins, Thomas Lohse, Frank M. Rieger, Hester Schutte, Carlo van Rensburg, Francois Brun, P. Vincent, Heiko Salzmann, Mathieu Bony, Oguzhan Anguener, Kirsty Feijen, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Ramin Marx, Dmitriy Kostunin, M. Panter, U. Katz, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Jaqueline Catalano, R. Konno, Hector Rueda Ricarte, T. Chand, Samuel Zouari, P. T. O'Brien, M. Hörbe, Celine Armand, Andreas Quirrenbach, Guillem Marti'i-Devesa, Faical Ait-Benkhali, Andrew Taylor, G. Vasileiadis, Vincent Marandon, Brian van Soelen, Marek Jamrozy, Hannes Thiersen, Dieter Horns, Hassan Abdalla, Thomas Bylund, Rowan Batzofin, Sébastien Le Stum, Thomas Tavernier, Gilles Maurin, Floriane Cangemi, Helene Sol, Christian Stegmann, Jacques Muller, Vardan Baghmanyan, Johannes Schaefer, J. F. Glicenstein, Anu Kundu, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, Monica Barnard, L. Mohrmann, Arache Djannati-Ataï, C. Levy, Atreyee Sinha, Bruno Khelifi, Michal Ostrowski, J.-P. Lenain, Hugh Spackman, Michael Zacharias, Regis Terrier, Hannah Dalgleish, P. Reichherzer, Andreas Zmija, Gianluca Giavitto, Jacek Niemiec, M. Lemoine-Goumard, Paolo Marchegiani, Markus Holler, Carlo Romoli, Isak Delberth Davids, Stefan Funk, Alicja Wierzcholska, Olaf Reimer, Q. Remy, Felix Jankowsky, Michael Kreter, Anna Barnacka, Brian Reville, Connor Duffy, A. Fiasson, Roberta Zanin, Thomas Murach, Heike Prokoph, James Davies, Sumari Hattingh, Felix Aharonian, Richard White, Angel Noel, M. Fuessling, R. J. Tuffs, B. Bi, Christo Venter, Takaaki Tanaka, D. Malyshev, Jonathan Mackey, Jacco Vink, Ira Jung, Sebastian Panny, Alison Mitchell, Anita Reimer, David Huber, Sabrina Casanova, Marion Spir-Jacob, Mischa Breuhaus, Pauline Chambery, Gerd Puehlhofer, C. Arcaro, C. Moore, Jhilik Majumdar, Lei Sun, Santiago Pita, Hambeleleni Ndiyavala, S. Steinmassl, Sami Caroff, Anton Dmytriiev, Dorit Glawion, G. Peron, Garret Cotter, Alexandre Marcowith, Felix Werner, Amid Nayerhoda, Manami Sasaki, Tomasz Bulik, Zhiqiu Huang, Malgorzata Curlo, Maria Haupt, Andrea Santangelo, Arnaud Mares, Lente Dreyer, D. A. Prokhorov, K. Kosack, V. Sahakian, Gavin Rowell, Jean-Pierre Ernenwein, N. Zywucka, Denys Malyshev, Markus Boettcher, Yves Gallant, Christopher van Eldik, Rafal Moderski, Johannes Veh, Samuel Timothy Spencer, Mohanraj Senniappan, Rachel Simoni, Dan Parsons, Krzysztof Katarzynski, Catherine Boisson, Justine Devin, Lenka Tomankova, Martin Tluczykont, Gašper Kukec Mezek, Hend Yassin, Manuel Meyer, Mathieu Naurois, Jason John Watson, S. J. Fegan, Nukri Komin, Tom Armstrong, David Sanchez, Werner Hofmann, Laura Olivera-Nieto, and A. Yusafzai
Subjects: Physics, Annihilation, WIMP, Milky Way, Weakly interacting massive particles, media_common.quotation_subject, Dark matter, Astrophysics::Cosmology and Extragalactic Astrophysics, Halo, Astrophysics, Galaxy, Universe, media_common
Abstract: The presence of dark matter (DM) is suggested by a wealth of astrophysical and cosmological measurements. However, its underlying nature is yet unknown. Among the most promising candidates are weakly interacting massive particles (WIMPs): particles with mass and coupling strength at the electroweak scale and thermally produced in the early universe have a present relic density consistent with that observed today. WIMP self-annihilation would produce Standard Model particles including gamma-rays, which have been long-time recognized as a prime messenger to indirectly detect dark matter signals. The centre of the Milky Way is predicted as the brightest source of DM annihilations. The H.E.S.S. collaboration is currently performing a survey of the inner region of the Milky Way, the Inner Galaxy Survey (IGS), intended to achieve the best sensitivity to faint and diffuse emissions in a region of several degrees around the Galactic Centre. We analyzed 2014-2020 observations taken with the five-telescope array to search for a DM annihilation signal. With the current dataset of about 550 hours, we found no significant excess and therefore derived strong constraints on the velocity-weighted annihilation cross-section. TeV thermal WIMPs can be probed in different annihilation channels.
Published: 2021

24. Southern African Large Telescope Spectroscopy of BL Lacs for the CTA project

Author: J.-P. Lenain, P. Goldoni, V. Navarro-Aranguiz, Michael Backes, Stephan Wagner, David A. Williams, H. Sol, J. Becerra-Gonzalez, O. Hervet, Garret Cotter, U. Barres de Almeida, Elina Lindfors, E. Kasai, S. Pita, Filippo D'Ammando, Catherine Boisson, Walter Max-Moerbeck, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Subjects: Active galactic nucleus, Cherenkov Telescope Array, Astrophysics::High Energy Astrophysical Phenomena, Population, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, High Energy Physics - Experiment, blazar, High Energy Physics - Experiment (hep-ex), Observatory, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], AGN, education, Blazar, Astrophysics::Galaxy Astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), education.field_of_study, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, redshift, Redshift, observatory, gamma ray: VHE, 13. Climate action, galaxy, Southern African Large Telescope, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], BL Lac object
Abstract: In the last two decades, very-high-energy gamma-ray astronomy has reached maturity: over 200 sources have been detected, both Galactic and extragalactic, by ground-based experiments. At present, Active Galactic Nuclei (AGN) make up about 40% of the more than 200 sources detected at very high energies with ground-based telescopes, the majority of which are blazars, i.e. their jets are closely aligned with the line of sight to Earth and three quarters of which are classified as high-frequency peaked BL Lac objects. One challenge to studies of the cosmological evolution of BL Lacs is the difficulty of obtaining redshifts from their nearly featureless, continuum- dominated spectra. It is expected that a significant fraction of the AGN to be detected with the future Cherenkov Telescope Array (CTA) observatory will have no spectroscopic redshifts, compromising the reliability of BL Lac population studies, particularly of their cosmic evolution. We started an effort in 2019 to measure the redshifts of a large fraction of the AGN that are likely to be detected with CTA, using the Southern African Large Telescope (SALT). In this contribution, we present two results from an on-going SALT program focused on the determination of BL Lac object redshifts that will be relevant for the CTA observatory., 15 pages, 4 figures, 37th International Cosmic Ray Conference
Published: 2021

25. Revealing x-ray and gamma ray temporal and spectral similarities in the GRB 190829A afterglow

Author: K. Egberts, Davit Zargaryan, Axel Donath, A. W. Chen, G. Pühlhofer, M. de Bony de Lavergne, V. Poireau, P. T. O'Brien, P. A. Evans, Riaan Steenkamp, A. Lemiere, F. Eichhorn, Nu. Komin, J. Schäfer, Włodek Kluźniak, A. S. Seyffert, N. Shafi, Natalia Żywucka, Sebastian Panny, R. J. White, Domenico Tiziani, D. Malyshev, T. Chand, Jhilik Majumdar, V. Baghmanyan, Clemens Hoischen, A. A. Zdziarski, Jacco Vink, Alison Mitchell, Joachim Hahn, M. Füßling, C. van Eldik, J.F. Glicenstein, Lei Sun, P. Reichherzer, Jim Davies, A. Carosi, Zorawar Wadiasingh, Q. Remy, Anna Barnacka, A. Djannati-Ataï, A. Montanari, E. Moulin, M. de Naurois, Alexandre Marcowith, Arnaud Mares, Christoph Deil, Sabrina Casanova, Christo Venter, G. Peron, Garret Cotter, M. Hörbe, Dmitriy Kostunin, E. Ruiz-Velasco, Mohanraj Senniappan, Thomas Bylund, E. O. Angüner, S. Raab, Tadayuki Takahashi, F. Brun, R. J. Tuffs, B. Bi, H. Prokoph, C. van Rensburg, A. Zech, J. Muller, Monica Barnard, B. Peyaud, Kirsty Feijen, R. Rauth, Pierre Brun, Victor Doroshenko, Michael Punch, E. Kasai, Konrad Bernlöhr, M. Curyło, Stefano Gabici, Gianluca Giavitto, Frank M. Rieger, Michael Backes, Stefan Klepser, J.-P. Ernenwein, A. Dmytriiev, Mischa Breuhaus, J. Dyks, G. Emery, L. Olivera-Nieto, Tim Holch, S. Fegan, Samuel Zouari, M.-H. Grondin, L. Mohrmann, Stefan Ohm, I. Jung-Richardt, Markus Böttcher, K. Kosack, A. Reimer, G. Hermann, Marek Jamrozy, Regis Terrier, S. Pita, Markus Holler, Felix Jankowsky, Armelle Jardin-Blicq, E. de Ona Wilhelmi, A.M. Taylor, Carlo Romoli, J. Damascene Mbarubucyeye, Hester Schutte, Dieter Horns, Jonathan Mackey, Tom Armstrong, Helene Sol, Sylvia Zhu, P. J. Meintjes, Hambeleleni Ndiyavala, G. Fontaine, H. Odaka, Felix Aharonian, V. Barbosa Martins, Andreas Specovius, Michal Ostrowski, Johannes Veh, D. J. van der Walt, Yu Wun Wong, L. Oakes, C. Moore, J. Bolmont, D. Jankowsky, M. Seglar-Arroyo, Paolo Marchegiani, Rachel Simoni, R. Marx, S. Steinmassl, D. Glawion, Łukasz Stawarz, Manuel Meyer, Tomasz Bulik, Lente Dreyer, Andreas Quirrenbach, Sabrina Einecke, Iryna Lypova, Constantin Steppa, D. A. Prokhorov, M. Zacharias, Christopher J. Duffy, A. Wierzcholska, M. Tluczykont, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, F. Schüssler, Yvonne Becherini, Jimmy N.S. Shapopi, C. Levy, Werner Hofmann, G. Lamanna, M. A. Kastendieck, James E. M. Watson, Ullrich Schwanke, G. Vasileiadis, Isak Delberth Davids, Misao Sasaki, Bruno Khelifi, M. Büchele, M. Lemoine-Goumard, J. Zorn, Elisabetta Bissaldi, Roberta Zanin, F. Ait Benkhali, L. Rinchiuso, M. Scalici, Y. A. Gallant, J. Devin, Jim Hinton, D. Berge, V. Sahakian, F. Werner, Andrea Santangelo, Stefan Funk, S. Sailer, Dmitry Khangulyan, Michael Kreter, Jacek Niemiec, D. A. Sanchez, A. Priyana Noel, C. Arcaro, Fabian Leuschner, J. H. E. Thiersen, M. Panter, U. Katz, K. Nakashima, Olaf Reimer, G. Martí-Devesa, H. Ashkar, Q. Piel, P. Morris, Gavin Rowell, M. Bryan, Kleopas Shiningayamwe, A. Yusafzai, Thomas Murach, G. Maurin, Maria Haupt, Heinrich J. Völk, M. Renaud, R. D. Parsons, Samuel Timothy Spencer, Lenka Tomankova, T. Tam, G. Fichet de Clairfontaine, A. Sinha, J.-P. Lenain, D. Huber, Rafal Moderski, S. Caroff, B. van Soelen, S. Chandra, R. Konno, L. Dirson, M. Tsirou, B. Rudak, V. Joshi, Thomas Lohse, L. Giunti, A. Nayerhoda, Hassan Abdalla, A. Fiasson, M. Spir-Jacob, V. Marandon, K. Katarzyński, P. Vincent, T. Tavernier, K. L. Page, Heiko Salzmann, Celine Armand, Catherine Boisson, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), H.E.S.S., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), H.E.S.S. Collaboration, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Photon, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, 01 natural sciences, Luminosity, HESS, 0103 physical sciences, High Energy Stereoscopic System, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, energy: high, Multidisciplinary, X-ray: energy spectrum, 010308 nuclear & particles physics, photon, Gamma ray, trigger, Light curve, redshift, Redshift, Afterglow, collapse, gamma ray: VHE, HESS - Abteilung Hinton, spectral, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], absorption
Abstract: An intrinsic gamma-ray burst afterglow Long gamma-ray bursts (GRBs) are emitted by relativistic jets generated during the collapse of a massive star in a distant galaxy. The GRB itself lasts only a few seconds but is followed by an afterglow that can persist for hours or days. The H.E.S.S. Collaboration observed the afterglow of GRB 190829A, a nearby long GRB. The proximity of this burst allowed it to be detected at tera–electron volt energies that would otherwise be absorbed in the intergalactic medium. By analyzing the spectrum and light curve at x-ray and gamma-ray wavelengths, the authors show that the afterglow cannot be explained by standard models. Science , abe8560, this issue p. 1081
Published: 2021

26. Deep observations of Kepler's SNR with H.E.S.S

Author: Jason John Watson, Kleopas Shiningayamwe, Edna Ruiz Velasco, Lenka Tomankova, Martin Tluczykont, Gašper Kukec Mezek, Hend Yassin, Manuel Meyer, Mathieu Naurois, Anton Dmytriiev, Manami Sasaki, Riaan Steenkamp, Andrea Santangelo, T. Chand, Gilles Maurin, J. F. Glicenstein, Jhilik Majumdar, Johannes Schaefer, Christian Stegmann, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, Bruno Khelifi, Anu Kundu, Hector Rueda Ricarte, Davit Zargaryan, Jacek Niemiec, L. Mohrmann, Arache Djannati-Ataï, Albert Seyffert, V. Sahakian, Anna Barnacka, P. Reichherzer, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Ira Jung, Olaf Reimer, G. Peron, Christo Venter, Garret Cotter, Sebastian Panny, K. Nakashima, K. Bernloehr, Isak Delberth Davids, Victor Barbosa Martins, A. Fiasson, Roberta Zanin, Yves Gallant, Fabian Schüssler, Michael Backes, Heinrich J. Völk, Gerd Puehlhofer, Lei Sun, Thomas Murach, Jean-Pierre Ernenwein, Emmanuel Moulin, G. Lamanna, V. Poireau, Jimmy N.S. Shapopi, Alexandre Marcowith, Felix Werner, Laenita Lorraine Oberholzer, Tim Holch, Naomi Tsuji, Carlo van Rensburg, Zhiqiu Huang, D. A. Prokhorov, K. Kosack, Tadayuki Takahashi, Markus Holler, Q. Remy, Felix Jankowsky, Victor Doroshenko, Felix Aharonian, Johannes Veh, Gerard Fontaine, E. Kasai, G. Vasileiadis, M.-H. Grondin, Anne Lemiere, Floriane Cangemi, Arnaud Mares, Samuel Zouari, Denys Malyshev, Alison Mitchell, Samuel Timothy Spencer, Hester Schutte, Stefan Klepser, Andreas Specovius, Alessandro Montanari, Andreas Zmija, Clemens Hoischen, A. A. Zdziarski, M. Lemoine-Goumard, Emma Ona-Wilhelmi, Yu Wun Wong, Stefan Ohm, Dan Parsons, Johann van der Walt, Vikas Joshi, Brian Reville, Connor Duffy, Michael Kreter, Gianluca Giavitto, D. Malyshev, Thomas Lohse, Mohanraj Senniappan, James Davies, Vincent Marandon, Hannes Thiersen, R. J. Tuffs, Hannah Dalgleish, Vardan Baghmanyan, P. T. O'Brien, Stefano Gabici, Thomas Bylund, Krzysztof Katarzynski, Michal Ostrowski, B. Bi, J.-P. Lenain, Catherine Boisson, Hugh Spackman, Michael Punch, Lukasz Stawarz, Sumari Hattingh, Monica Barnard, Jaqueline Catalano, Takaaki Tanaka, Rowan Batzofin, Mischa Breuhaus, Pauline Chambery, Stefan Funk, Alicja Wierzcholska, R. Konno, Ramin Marx, M. Panter, Anna Luashvili, Justine Devin, J. Bolmont, U. Katz, Francois Brun, Richard White, Jacques Muller, Andrew Taylor, P. Vincent, N. Zywucka, Andreas Quirrenbach, Laura Olivera-Nieto, A. Yusafzai, Dieter Horns, Guillem Marti'i-Devesa, Hassan Abdalla, Heiko Salzmann, Jacco Vink, Mathieu Bony, Oguzhan Anguener, Michael Zacharias, Celine Armand, Atreyee Sinha, Marek Jamrozy, Kirsty Feijen, Faical Ait-Benkhali, Lott Frans, Robert Brose, Santiago Pita, Hambeleleni Ndiyavala, L. Giunti, David Huber, German Hermann, Paul Morris, M. Hörbe, Helene Sol, Sabrina Casanova, Jim Hinton, S. Sailer, Dmitry Khangulyan, Charles Thorpe-Morgan, Sébastien Le Stum, Paolo Marchegiani, Michelle Tsirou, Constantin Steppa, Halim Ashkar, Fabian Leuschner, Ullrich Schwanke, C. Arcaro, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Gavin Rowell, Regis Terrier, B. Rudak, Carlo Romoli, Kathrin Egberts, Nukri Komin, Tom Armstrong, Frank M. Rieger, Matthieu Renaud, M. Fuessling, David Sanchez, Heike Prokoph, C. Levy, S. Steinmassl, Sami Caroff, Werner Hofmann, Marion Spir-Jacob, S. J. Fegan, Amid Nayerhoda, Sylvia Zhu, P. J. Meintjes, David Berge, Maria Haupt, Christopher van Eldik, Rafal Moderski, Dmitriy Kostunin, Brian van Soelen, Thomas Tavernier, Markus Boettcher, Sabrina Einecke, Iryna Lypova, Anita Reimer, Yvonne Becherini, Rachel Simoni, Angel Noel, Jonathan Mackey, C. Moore, Dorit Glawion, Tomasz Bulik, Malgorzata Curlo, Lente Dreyer, Louis Du Plessis, Naurois , Mathieu, Ona-Wilhelmi , Emma, and Bony , Mathieu
Subjects: Astrophysics::High Energy Astrophysical Phenomena, atmosphere [Cherenkov counter], VHE [gamma ray], IACT, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Cherenkov counter: atmosphere, Kepler, HESS, supernova, Astrophysics::Solar and Stellar Astrophysics, ddc:530, High Energy Stereoscopic System, cosmic radiation: acceleration, Supernova remnant, Cherenkov radiation, Astrophysics::Galaxy Astrophysics, Physics, energy: high, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, Galaxy, Cassiopeia A, Supernova, gamma ray: VHE, high [energy], acceleration [cosmic radiation], galaxy
Abstract: 37th International Cosmic Ray Conference, ICRC 2021, Berlin, online, Germany, 12 Jul 2021 - 23 Jul 2021; Proceedings of Science / International School for Advanced Studies (ICRC2021), 805 (2021). doi:10.22323/1.395.0805, Kepler��s supernova remnant (SNR) which is produced by the most recent naked-eye supernova in our Galaxy is one of the best studied SNRs, but its gamma-ray detection has eluded us so far. Observations with modern imaging atmospheric Cherenkov telescopes (IACT) have enlarged the knowledge about nearby SNRs with ages younger than 500 years by establishing Cassiopeia A and Tycho��s SNRs as very high energy (VHE) gamma-ray sources and setting a lower limit on the distance to Kepler��s SNR. This SNR is significantly more distant than the other two and expected to be one of the faintest gamma-ray sources within reach of the IACT arrays of this generation. We report strong evidence for a VHE signal from Kepler��s SNR based on deep observations of the High Energy Stereoscopic System (H.E.S.S.) with an exposure of 152 hours, including 122 hours accumulated in 2017-2020. We further discuss implications of this result for cosmic-ray acceleration in young SNRs., Published by SISSA, Trieste
Published: 2021

27. The young massive stellar cluster Westerlund 1 in gamma rays as seen with H.E.S.S

Author: Lars Mohrmann, Hassan Abdalla, Felix Aharonian, Faical Ait-Benkhali, Oguzhan Anguener, Cornelia Arcaro, Celine Armand, Tom Armstrong, Halim Ashkar, Michael Backes, Vardan Baghmanyan, Victor Barbosa Martins, Anna Barnacka, Monica Barnard, Rowan William Batzofin, Yvonne Becherini, David Berge, Konrad Bernloehr, Baiyang Bi, Markus Böttcher, Catherine Boisson, Julien Bolmont, Mathieu Bony (de), Mischa Breuhaus, Robert Brose, Francois Brun, Tomasz Bulik, Thomas Bylund, Floriane Cangemi, Sami Caroff, Sabrina Casanova, Jaqueline Catalano, Pauline Chambery, Tej Bahadur Chand, Andrew Chen, Garret Cotter, Malgorzata Curlo, Hannah Dalgleish, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James Davies, Justine Devin, Arache Djannati-Ataï, Anton Dmytriev, Axel Donath, Victor Doroshenko, Lente Dreyer, Louis Du Plessis, Connor Duffy, Kathrin Egberts, Sabrina Einecke, Jean-Pierre ERNENWEIN, Steven Fegan, Kirsty Feijen, Armand Fiasson, Gaëtan Fichet de Clairfontaine, Gerard Fontaine, Lott Frans, Matthias Fuessling, Stefan Funk, Stefano Gabici, Yves Gallant, Gianluca Giavitto, Luca Giunti, Dorit Glawion, Jean-Francois Glicenstein, Marie-Hélène Grondin, Sumari Hattingh, Maria Haupt, German HERMANN, Jim Hinton, Werner Hofmann, Clemens Hoischen, Tim Holch, Markus Holler, Dieter Horns, Zhi-Qiu Huang, David Huber, Mario Hörbe, Marek Jamrozy, Felix Jankowsky, Vikas Joshi, Ira JUNG, Eli Kasai, Krzysztof Katarzynski, Ulì Katz, Dmitry Khangulyan, Bruno Khelifi, Stefan Klepser, Wlodek Kluzniak, Nukri Komin, Ruslan Konno, Karl Kosack, Dmitriy Kostunin, Michael Kreter, Gašper Kukec Mezek, Anu Kundu, Giovanni Lamanna, Sebastien Le Stum, Anne Lemiere, Marianne Lemoine-Goumard, Jean-Philippe Lenain, Fabian Leuschner, Christelle Levy, Thomas Lohse, Anna Luashvili, Iryna Lypova, Jonathan Mackey, Jhilik Majumdar, Denys Malyshev, Dmitry Malyshev, Vincent Marandon, Paolo Marchegiani, Alexandre Marcowith, Arnaud Mares, Guillem Martí-Devesa, Ramin Marx, Gilles Maurin, Pieter Meintjes, Manuel Meyer, Alison Mitchell, Rafal Moderski, Alessandro Montanari, Chris Moore, Paul Morris, Emmanuel Moulin, Jacques Muller, Thomas Murach, Kaori Nakashima, Mathieu Naurois (de), Amid Nayerhoda, Hambeleleni Davids, Jacek Niemiec, Angel Noel, Paul O'Brien, Laenita Lorraine Oberholzer, Stefan Ohm, Laura Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal Ostrowski, Sebastian Panny, Michael Panter, Dan Parsons, Giada Peron, Santiago Pita, Vincent Poireau, Dmitry A Prokhorov, Heike Prokoph, Gerd PUEHLHOFER, Michael Punch, Andreas Quirrenbach, Romed Rauth, Patrick Reichherzer, Anita Reimer, Olaf Reimer, Quentin Remy, Matthieu Renaud, Brian Reville, Frank Rieger, Carlo Romoli, Gavin P Rowell, Bronislaw Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan Sahakian, Simon Sailer, Heiko Salzmann, David Sanchez, Andrea Santangelo, Manami Sasaki, Johannes Schaefer, Hester Schutte, Ullrich Schwanke, Fabian Schüssler, Mohanraj Senniappan, Albert Seyffert, Jimmy N.S. Shapopi, Kleopas Shiningayamwe, Rachel Simoni, Atreyee Sinha, Helene Sol, Hugh Spackman, Andreas Specovius, Samuel Timothy Spencer, Marion Spir-Jacob, Lukasz Stawarz, Riaan Steenkamp, Christian Stegmann, Simon Steinmassl, Constantin Steppa, Lei Sun, Tadayuki Takahashi, Takaaki Tanaka, Thomas Tavernier, Andrew Taylor, Regis Terrier, Hannes Thiersen, Charles Thorpe-Morgan, Martin Tluczykont, Lenka Tomankova, Michelle Tsirou, Naomi Tsuji, Richard Tuffs, Yasunobu Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George Vasileiadis, Johannes Veh, Christo Venter, Pascal Vincent, Jacco Vink, Heinrich J. Völk, Stefan Wagner, Jason John Watson, Felix Werner, Richard White, Alicja Wierzcholska, Yu Wun Wong, Hend Mahmoud Yassin, Anke Yusafzai, Michael Zacharias, Roberta Zanin, Davit Zargaryan, Andrzej Zdziarski, Andreas Zech, Sylvia Zhu, Andreas Zmija, Samuel Zouari, Natalia Żywucka, Naurois , Mathieu, Ona-Wilhelmi , Emma, and Bony , Mathieu
Subjects: Physics, Milky Way, Astrophysics::High Energy Astrophysical Phenomena, Hadron, Gamma ray, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Likelihood analysis, Energy spectrum, Cluster (physics), ddc:530, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::Galaxy Astrophysics
Abstract: 37th International Cosmic Ray Conference, ICRC 2021, Berlin, online, Germany, 12 Jul 2021 - 23 Jul 2021; Proceedings of Science / International School for Advanced Studies (ICRC2021), 789 (2021). doi:10.22323/1.395.0789, Massive stellar clusters have recently been hypothesised as candidates for the acceleration of hadronic cosmic rays up to PeV energies. Previously, the H.E.S.S. Collaboration has reported about very extended $\gamma$-ray emission around Westerlund 1, a massive young stellar cluster in the Milky Way. In this contribution we present an updated analysis that employs a new analysis technique and is based on a much larger data set, allowing us to constrain better the morphology and the energy spectrum of the emission. The analysis technique used is a three-dimensional likelihood analysis, which is especially well suited for largely extended sources. The origin of the $\gamma$-ray emission will be discussed in light of multi-wavelength observations., Published by SISSA, Trieste
Published: 2021

28. H.e.s.s. And magic observations of a sudden cessation of a very-high-energy γ -ray flare in PKS 1510-089 in May 2016

Author: A. Yusafzai, J. van Scherpenberg, M. Büchele, B. Boccardi, S. Caroff, S. J. Fegan, Daniela Dorner, T. Schweizer, Mosè Mariotti, Gaia Vanzo, Tom Armstrong, Nu. Komin, Pratik Majumdar, M. V. Fonseca, Matteo Cerruti, A. Lemiere, F. Eichhorn, J. Devin, C. Trichard, Michael Punch, Stefano Gabici, M. Palatiello, V. A. Acciari, F. Schüssler, Sylvia Zhu, P. J. Meintjes, Werner Hofmann, Samuel Timothy Spencer, Y. Kajiwara, J. Zorn, D. Dominis Prester, S. Bonnefoy, Constantin Steppa, G. Maurin, Adrian Biland, J. M. Paredes, Antonio Stamerra, U. Barres de Almeida, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, Davide Depaoli, Dmitriy Kostunin, R. Mirzoyan, T. Surić, D. Gottschall, M. Füßling, Moritz Hütten, Lea Heckmann, M. Gaug, J. Herrera, Ullrich Schwanke, C. Arcaro, H. Abdalla, Lorenzo Bellizzi, Thomas P. Krichbaum, Francesco Dazzi, John Hoang, Martin Will, Dominik Baack, L. Maraschi, Elina Lindfors, M. A. Kastendieck, R. Rauth, V. Baghmanyan, D. Ninci, Koji Noda, Michael Backes, S. Raab, Sanae Inoue, Giacomo D'Amico, Manuel Meyer, Q. Remy, L. Olivera-Nieto, Dorota Sobczyńska, Elisa Bernardini, M. Filipovic, Riaan Steenkamp, Davit Zargaryan, Hambeleleni Ndiyavala, Stefan Klepser, G. Vasileiadis, G. Lamanna, S. G. Jorstad, Daniel Mazin, Jacek Niemiec, Kirsty Feijen, Alessandro Montanari, Tim Holch, Seiya Nozaki, Anna Barnacka, M. Hörbe, Giacomo Bonnoli, D. Strom, T. Tavernier, Takeshi Oka, Axel Donath, J. Rico, A. W. Chen, J. Dyks, T. Chand, Jim Hinton, F. Niederwanger, Olaf Reimer, Daniel Kerszberg, Manuel Delfino, Krzysztof Katarzynski, Ivica Puljak, S. Sailer, Dmitry Khangulyan, Christian Fruck, Gavin Rowell, D. A. Sanchez, Maria Haupt, Julian Sitarek, Alan P. Marscher, Stefano Truzzi, Pablo Peñil, E. O. Angüner, Catherine Boisson, S. Ventura, Dieter Horns, M. Bryan, V. Barbosa Martins, L. Sun, Rachel Simoni, Gerard Fontaine, Jacco Vink, P. Reichherzer, Jim Davies, G. Hermann, Regis Terrier, Clemens Hoischen, A. A. Zdziarski, G. Ferrara, Francois Brun, G. Emery, M. de Bony de Lavergne, P. Vincent, Kyoshi Nishijima, Alessandra Lamastra, G. Fichet de Clairfontaine, E. de Oña Wilhelmi, P. Munar-Adrover, Yoshiki Ohtani, Carlo Romoli, Jordi Delgado, Wrijupan Bhattacharyya, L. Di Venere, D. Zarić, Zorawar Wadiasingh, F. Di Pierro, Ž. Bošnjak, Hester Schutte, Isak Delberth Davids, Roberta Zanin, Karl Mannheim, M. Strzys, Łukasz Stawarz, R. J. Tuffs, V. Fallah Ramazani, B. Bi, Marc Ribó, Sabrina Casanova, H. Prokoph, A. Carosi, Stefano Covino, D. J. van der Walt, Thomas Murach, Yating Chai, Saša Mićanović, Jae-Young Kim, V. Vitale, Francesco Longo, R. Konno, Alicia Fattorini, Narek Sahakyan, Y. A. Gallant, R. J. García López, Junko Kushida, Jürgen Besenrieder, Dario Hrupec, P. Da Vela, S. Steinmassl, P. G. Prada Moroni, Jonathan Mackey, Rafal Moderski, Stefan Cikota, Hidetoshi Kubo, Armelle Jardin-Blicq, Monica Barnard, J. Otero-Santos, Mischa Breuhaus, J. Becerra González, Yu. W. Wong, V. Joshi, Samuel Zouari, N. Shafi, Natalia Żywucka, E. Prandini, M. A. Lopez, Gianluca Giavitto, Katsuaki Asano, Mitsunari Takahashi, T. Vuillaume, M. Curyło, P. Morris, K. Egberts, Stefano Ansoldi, M. de Naurois, Pawel Gliwny, L. Pavletić, C. Moore, Alessia Spolon, M. Vazquez Acosta, D. Elsaesser, Tomoki Saito, Giovanni Ceribella, Riccardo Paoletti, Celine Armand, Jhilik Majumdar, Stefan Ohm, G. Busetto, Léa Jouvin, Ana Babić, Frank M. Rieger, A. Dmytriiev, Dorit Glawion, Z. R. Weaver, Włodek Kluźniak, S. Chandra, V. Marandon, A. Djannati-Ataï, E. Moulin, Tomasz Bulik, Alessio Berti, M. Seglar-Arroyo, H. Odaka, Christian Stegmann, Stefan Wagner, C. Perennes, Pierre Brun, Yasunobu Uchiyama, A. Fiasson, U. Colin, David A. Green, Kazuma Ishio, A. Arbet Engels, A. De Angelis, Wlodek Bednarek, Nikola Godinovic, F. Ait Benkhali, Vassil Verguilov, Camilla Maggio, L. Mohrmann, Jean-Pierre Ernenwein, M. Spir-Jacob, M. Karjalainen, Vitaly Neustroev, P. deWilt, M. Scalici, Victoria Moreno, A. Priyana Noel, A. López-Oramas, M. Lemoine-Goumard, N. Torres-Albà, Martin Makariev, C. van Rensburg, Oscar Blanch, S. Pita, Alexander Hahn, V. Sahakian, Yusuke Suda, S. Schwemmer, Thomas Lohse, Misao Sasaki, Daniel Morcuende, Johannes Veh, D. Jankowsky, Michael Kreter, D. Berge, Luca Tosti, R. Marx, F. Werner, V. Poireau, Andrea Santangelo, C. Nigro, Andreas Quirrenbach, Jose Luis Contreras, E. Ruiz-Velasco, Thomas Bylund, M. Tluczykont, V. D'Elia, A. S. Seyffert, Jose Miguel Miranda, Massimo Persic, L. Dirson, Efthalia Traianou, Carlo Vigorito, Sargis Gasparyan, Y. Kobayashi, Jacques Muller, Jeffrey A. Hodgson, Marek Jamrozy, Christoph Deil, I. Jung-Richardt, Joachim Hahn, Mohanraj Senniappan, A. Rugliancich, Marina Manganaro, K. Nakashima, Kleopas Shiningayamwe, Alice Donini, Michelle Tsirou, Yuki Iwamura, G. Maneva, L. A. Antonelli, Juan Cortina, Markus Holler, Michal Ostrowski, Wolfgang Rhode, L. Rinchiuso, Felix Jankowsky, Sebastian Panny, M. I. Martínez, Michael Zacharias, Ferdinando Giordano, Felix Aharonian, Lluis Font, J.-P. Lenain, Merja Tornikoski, B. Machado de Oliveira Fraga, M.-H. Grondin, Lenka Tomankova, Markus Böttcher, Alison Mitchell, Chiara Righi, E. Do Souto Espiñeira, Tomislav Terzić, Alexandre Marcowith, P. Temnikov, Helene Sol, Sabrina Einecke, Iryna Lypova, Toshiaki Inada, Rodolfo Carosi, R. D. Parsons, Yvonne Becherini, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Arnaud Mares, Chaitanya Priyadarshi, Satoshi Fukami, Konstancja Satalecka, Stefan Funk, Johan Bregeon, Sidika Merve Colak, Alicja Wierzcholska, R. J. White, F. Leone, Michele Doro, D. Huber, Carolina Casadio, Anne Lähteenmäki, Masahiro Teshima, Domenico Tiziani, D. Malyshev, M. Panter, U. Katz, Heinrich J. Völk, G. Martí-Devesa, C. Levy, M. Renaud, J. A. Barrio, Kai Phillip Schmidt, L. Oakes, N. Giglietto, Simone Mender, Paolo Marchegiani, Ashot Chilingarian, Tjark Miener, James E. M. Watson, David Paneque, J. Bolmont, Manuela Mallamaci, Halim Ashkar, A. Sinha, Fabrizio Tavecchio, Kari Nilsson, B. van Soelen, B. Rudak, R. Adam, D. Miceli, M. Mohamed, Saverio Lombardi, E. Molina, P. T. O'Brien, E. Colombo, Lab Saha, Luca Foffano, C. van Eldik, G. Peron, Garret Cotter, D. Hadasch, D. A. Prokhorov, K. Kosack, Konrad Bernlöhr, B. Peyaud, I. Vovk, G. Pühlhofer, A. Reimer, J. F. Glicenstein, Bruno Khelifi, Serena Loporchio, I. Snidaric, Abelardo Moralejo, Andreas Specovius, E. Moretti, Bernd Schleicher, M. Minev, B. De Lotto, Andrés Baquero, A.M. Taylor, J. Damascene Mbarubucyeye, Christo Venter, Ciro Bigongiari, A. Zech, M. Garczarczyk, R. López-Coto, Q. Piel, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., MAGIC, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Academy of Finland, University of Tokyo, La Caixa, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Abdalla, H., Adam, R., Aharonian, F., Ait Benkhali, F., Ang??ner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernl??hr, K., Bi, B., B??ttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., de Bony de Lavergne, M., Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., B??chele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Cury??o, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Ata??, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., Fichet de Clairfontaine, G., Filipovic, M., Fontaine, G., Funk, S., F????ling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., H??rbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzy??ski, K., Katz, U., Khangulyan, D., Kh??lifi, B., Klepser, S., Klu??niak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemi??re, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Mart??-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O???brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., de Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., P??hlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Sch??ssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, ??., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., V??lk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., ywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Asano, K., Baack, D., Babi??, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Becerra Gonz??lez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bo??njak, ??., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D???amico, G., D???elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi??eira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garc??a L??pez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi??, N., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H??tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L??pez, M., L??pez-Coto, R., L??pez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Mart??nez, M., Mazin, D., Mender, S., Mi??anovi??, S., Miceli, D., Miener, T., Minev, M., Miranda, J. 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P., Boccardi, B., Casadio, C., Hodgson, J., Kim, J. -Y., Krichbaum, T. P., L??hteenm??ki, A., Tornikoski, M., Traianou, E., Weaver, Z. R., Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
Subjects: non-thermal, quasars: individual: PKS 1510−089, galaxies: active, relativistic processes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies [radiation mechanisms], Photon, individual: PKS 1510−089 [quasars], Astrophysics::High Energy Astrophysical Phenomena, Flux, radiation mechanisms: non-thermal / quasars: individual: PKS 1510−089 / galaxies: active / relativistic processes, radiation mechanisms: non-thermal, quasars: individual: PKS 1510-089, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, law, 0103 physical sciences, Galaxies: Active, Quasars: Individual: Pks 1510-089, Radiation mechanisms: Non-thermal, Relativistic processes, individual: PKS 1510-089 [quasars], MAGIC (telescope), 010303 astronomy & astrophysics, Physics, [PHYS]Physics [physics], 010308 nuclear & particles physics, Astronomy and Astrophysics, Quasar, Light curve, non-thermal [radiation mechanisms], relativistic processes [radiation mechanisms], Extragalactic background light, Space and Planetary Science, active [galaxies], ddc:520, Física nuclear, quasars: individual: PKS 1510��089, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope, Flare
Abstract: The flat spectrum radio quasar (FSRQ) PKS 1510−089 is known for its complex multiwavelength behaviour and it is one of only a few FSRQs detected in very-high-energy (VHE, E > 100 GeV) γ rays. The VHE γ-ray observations with H.E.S.S. and MAGIC in late May and early June 2016 resulted in the detection of an unprecedented flare, which revealed, for the first time, VHE γ-ray intranight variability for this source. While a common variability timescale of 1.5 h has been found, there is a significant deviation near the end of the flare, with a timescale of ∼20 min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, a curvature was detected in the VHE γ-ray spectrum of PKS 1510–089, which can be fully explained by the absorption on the part of the extragalactic background light. Optical R-band observations with ATOM revealed a counterpart of the γ-ray flare, even though the detailed flux evolution differs from the VHE γ-ray light curve. Interestingly, a steep flux decrease was observed at the same time as the cessation of the VHE γ-ray flare. In the high-energy (HE, E > 100 MeV) γ-ray band, only a moderate flux increase was observed with Fermi-LAT, while the HE γ-ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the γ-ray spectrum indicates that the emission region is located outside of the BLR. Radio very-long-baseline interferometry observations reveal a fast-moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located ∼50 pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this is indeed a true correlation, the VHE γ rays must have been produced far down in the jet, where turbulent plasma crosses a standing shock., Astronomy & Astrophysics, 648, ISSN:0004-6361, ISSN:1432-0746
Published: 2021

29. Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation

Author: J.-P. Lenain, A. Domínguez, Jonathan Ivor Davies, T. Armstrong, A. A. Zdziarski, F. Gianotti, M. Balbo, E. O. Angüner, M. Marculewicz, Alasdair E. Gent, Alice Donini, Olivier Hervet, Henry Przybilski, Giacomo Principe, G. Leto, M. Peresano, Stefano Covino, P. A. Caraveo, Gianpiero Tagliaferri, D. de Martino, V. V. Vassiliev, D. Cauz, F. R. Pantaleo, U. Barres de Almeida, Pietro Bruno, E. Lindfors, M. Zavrtanik, G. Hughes, Miriam Lucio Martinez, P. Bordas, Y. Suda, G. S. Varner, R. Rando, K. Cerny, S. Pita, Csaba Balázs, E. Fiandrini, Michael Backes, Tomohiko Oka, Massimo Persic, Andrea Chiavassa, Johannes Veh, A. Stamerra, Fabrizio Tavecchio, B. Biasuzzi, Michael Punch, Soebur Razzaque, F. D'Ammando, P. I. Batista, Bruna Bertucci, F. Longo, Francesco Gabriele Saturni, Michael G. Burton, Bohdan Hnatyk, P. Sangiorgi, E. M. Santos, D. Nosek, Gagik Tovmassian, J. L. Dournaux, Pedro L. Luque-Escamilla, A. Aguirre-Santaella, M. Orienti, Lluis Font, Andreas Quirrenbach, Philippe Laporte, Ralf Kissmann, Francesco Lucarelli, K. Noda, I. Jiménez Martínez, G. Romeo, Wystan Benbow, P. Romano, B. Bi, J. Grube, H.-S. Zechlin, Giacomo Bonnoli, Martin White, J. P. Osborne, Enrico Cascone, Marek Jamrozy, C. Alispach, Miroslav Pech, O. Cuevas, Petr Schovanek, K. Hayashi, V. I. Zhdanov, Javier Coronado-Blázquez, D. Medina Miranda, Barbara Balmaverde, E. de Ona Wilhelmi, Frank M. Rieger, A. Shalchi, J. M. Paredes, Ruben Alfaro, N. Giglietto, Diego Falceta-Gonçalves, Helene Sol, Rodolfo Carosi, Ayan Acharyya, Dominik Elsässer, S. Vercellone, D. Pimentel, T. Mizuno, Alessandro Bruno, Juan Abel Barrio, K. Kosack, Mauro Orlandini, Rodrigo Guedes Lang, P. Marquez, Adrian Biland, Y. Kobayashi, Nicholas F. H Tothill, M. de Naurois, Daniele Spiga, Lili Yang, L. Tibaldo, Pavel Horvath, M. Lopez, I. Sadeh, Marek Nikolajuk, F. Schüssler, Reshmi Mukherjee, Gianpaolo Vettolani, Jürgen Knödlseder, Daniel Nieto, R. Hnatyk, German Martinez, Diego F. Torres, Farinaldo S. Queiroz, N. Parmiggiani, G. Lamanna, Marcos Santander, S. Fegan, I. Vovk, M. Sánchez-Conde, Wiphu Rujopakarn, Norita Kawanaka, R. C. Shellard, Michael C. B. Ashley, J. Jurysek, Francisco J. Franco, Samuel Timothy Spencer, E. Rebert, J. Morales Merino, M. Pecimotika, Marco Berton, Regis Terrier, G. A. Beck, Carlos Díaz, J. L. Contreras, G. Zaharijas, R. Moderski, José-María Martí, A. Insolia, D. Zavrtanik, K. Kohri, Ladislav Chytka, T. Grabarczyk, A. Zech, M. Garczarczyk, Anastasia Sokolenko, J. Lefaucheur, R. A. Cameron, Moritz Hütten, S. Karkar, K. Pfrang, V. Poireau, Asaf Pe'er, A. Reimer, Fabio Acero, L. Freixas Coromina, David Sánchez, Jonathan S. Lapington, Konstantinos N. Gourgouliatos, J.R. Hörandel, Mario Buscemi, Francesco Dazzi, Abelardo Moralejo, J. Bolmont, R. White, A. Rosales de Leon, J. Prast, Sabrina Einecke, Roberto Aloisio, Yvonne Becherini, Andreas Specovius, Shohei Yanagita, Juan Cortina, Miroslav Hrabovsky, Petr Janecek, D. Depaoli, Lucas Taylor, U. Schwanke, H. Abdalla, S. Recchia, Manuela Mallamaci, M. K. Daniel, Q. Feng, L. Baroncelli, Hiromitsu Takahashi, Susumu Inoue, U. Straumann, Masatoshi Ohishi, Roberto Capuzzo-Dolcetta, Nu. Komin, Federico Russo, R. de Cássia dos Anjos, Y. Ohira, Ferdinando Giordano, Nagisa Hiroshima, E. Garcia, Gavin Rowell, V. Bozhilov, Maxim V. Barkov, Dario Hrupec, I. Oya, F. Salesa Greus, Anna Wolter, M. Živec, R. Belmont, R. Adam, T. Reposeur, J. Rico, A. W. Chen, G. Pühlhofer, H. Prokoph, Stefan Wagner, F. Di Pierro, Fabrizio Bocchino, M. de Bony de Lavergne, A. Kong, Masha Chernyakova, M. Pohl, M. Vazquez Acosta, A. Nagai, A. Brill, Dusan Mandat, Jonathan Biteau, Martin Makariev, Catherine Boisson, E. Lyard, Gilles Maurin, H. Martínez-Huerta, Oscar Blanch, Bernd Schleicher, M. Minev, A. Berti, James E. M. 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Goldoni, Gilles Fontaine, Hiroshi Muraishi, D. Mazin, Samo Stanič, G. Ghirlanda, M. Polo, M. Nievas, M. Lemoine-Goumard, Oleh Petruk, Jose Miguel Miranda, M. Iori, A. Marcowith, Y. Renier, Satoshi Fukami, M. Roncadelli, F. Leone, Takanori Yoshikoshi, Ana Luiza d'Ávila Viana, Y. Fukui, Max Harvey, Sera Markoff, I. Agudo, P. Temnikov, Vincenzo Testa, R. López-Coto, J.D. Mbarubucyeye, Tjark Miener, David Paneque, V. Gammaldi, T. Hassan Collado, H. Abe, L. Bonneau Arbeletche, S. D. Vergani, Sasa Micanovic, P. Vallania, Marina Manganaro, Elena Torresi, M. Giarrusso, G. Ferrand, Paweł Świerk, B. Patricelli, Matteo Cerruti, N. La Palombara, D. Morcuende-Parrilla, V. de Souza, Toshiaki Inada, Yasushi Fukazawa, Werner Hofmann, Michele Doro, E. Pueschel, A. Araudo, E. Sciacca, Thomas Lohse, A. Djannati-Ataï, Abdalla, H., Abe, H., Acero, F., Acharyya, A., Adam, R., Agudo, I., Aguirre-Santaella, A., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Alves Batista, R., Amati, L., Amato, E., Ambrosi, G., Ang??ner, E. O., Araudo, A., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ascas??bar, Y., Ashley, M., Backes, M., Balazs, C., Balbo, M., Balmaverde, B., Baquero Larriva, A., Barbosa Martins, V., Barkov, M., Baroncelli, L., Barres de Almeida, U., Barrio, J. A., Batista, P. -I., Becerra Gonz??lez, J., Becherini, Y., Beck, G., Becker Tjus, J., Belmont, R., Benbow, W., Bernardini, E., Berti, A., Berton, M., Bertucci, B., Beshley, V., Bi, B., Biasuzzi, B., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Bocchino, F., Boisson, C., Bolmont, J., Bonanno, G., Bonneau Arbeletche, L., Bonnoli, G., Bordas, P., Bottacini, E., B??ttcher, M., Bozhilov, V., Bregeon, J., Brill, A., Brown, A. M., Bruno, P., Bruno, A., Bulgarelli, A., Burton, M., Buscemi, M., Caccianiga, A., Cameron, R., Capasso, M., Caprai, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Carosi, R., Carosi, A., Casanova, S., Cascone, E., Cauz, D., Cerny, K., Cerruti, M., Chadwick, P., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Chiavassa, A., Chytka, L., Conforti, V., Conte, F., Contreras, J. L., Coronado-Blazquez, J., Cortina, J., Costa, A., Costantini, H., Covino, S., Cristofari, P., Cuevas, O., D'Ammando, F., Daniel, M. K., Davies, J., Dazzi, F., De Angelis, A., de Bony de Lavergne, M., De Caprio, V., de C??ssia dos Anjos, R., de Gouveia Dal Pino, E. M., De Lotto, B., De Martino, D., de Naurois, M., de O??a Wilhelmi, E., De Palma, F., de Souza, V., Delgado, C., Della Ceca, R., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Pierro, F., D??az, C., D??az-Bahamondes, C., Diebold, S., Djannati-Ata??, A., Dmytriiev, A., Dom??nguez, A., Donini, A., Dorner, D., Doro, M., Dournaux, J., Dwarkadas, V. V., Ebr, J., Eckner, C., Einecke, S., Ekoume, T. R. N., Els??sser, D., Emery, G., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Fegan, S., Feng, Q., Ferrand, G., Fiandrini, E., Fiasson, A., Fioretti, V., Foffano, L., Fonseca, M. V., Font, L., Fontaine, G., Franco, F. J., Freixas Coromina, L., Fukami, S., Fukazawa, Y., Fukui, Y., Gaggero, D., Galanti, G., Gammaldi, V., Garcia, E., Garczarczyk, M., Gascon, D., Gaug, M., Gent, A., Ghalumyan, A., Ghirlanda, G., Gianotti, F., Giarrusso, M., Giavitto, G., Giglietto, N., Giordano, F., Glicenstein, J., Goldoni, P., Gonz??lez, J. M., Gourgouliatos, K., Grabarczyk, T., Grandi, P., Granot, J., Grasso, D., Green, J., Grube, J., Gueta, O., Gunji, S., Halim, A., Harvey, M., Hassan Collado, T., Hayashi, K., Heller, M., Hern??ndez Cadena, S., Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., H??randel, J., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Hughes, G., H??tten, M., Iarlori, M., Inada, T., Inoue, S., Insolia, A., Ionica, M., Iori, M., Jacquemont, M., Jamrozy, M., Janecek, P., Jim??nez Mart??nez, I., Jin, W., Jung-Richardt, I., Jurysek, J., Kaaret, P., Karas, V., Karkar, S., Kawanaka, N., Kerszberg, D., Kh??lifi, B., Kissmann, R., Kn??dlseder, J., Kobayashi, Y., Kohri, K., Komin, N., Kong, A., Kosack, K., Kubo, H., La Palombara, N., Lamanna, G., Lang, R. G., Lapington, J., Laporte, P., Lefaucheur, J., Lemoine-Goumard, M., Lenain, J., Leone, F., Leto, G., Leuschner, F., Lindfors, E., Lloyd, S., Lohse, T., Lombardi, S., Longo, F., Lopez, A., L??pez, M., L??pez-Coto, R., Loporchio, S., Lucarelli, F., Luque-Escamilla, P. L., Lyard, E., Maggio, C., Majczyna, A., Makariev, M., Mallamaci, M., Mandat, D., Maneva, G., Manganaro, M., Manic??, G., Marcowith, A., Marculewicz, M., Markoff, S., Marquez, P., Mart??, J., Martinez, O., Mart??nez, M., Mart??nez, G., Mart??nez-Huerta, H., Maurin, G., Mazin, D., Mbarubucyeye, J. D., Medina Miranda, D., Meyer, M., Micanovic, S., Miener, T., Minev, M., Miranda, J. M., Mitchell, A., Mizuno, T., Mode, B., Moderski, R., Mohrmann, L., Molina, E., Montaruli, T., Moralejo, A., Morales Merino, J., Morcuende-Parrilla, D., Morselli, A., Mukherjee, R., Mundell, C., Murach, T., Muraishi, H., Nagai, A., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas, M., Nikolajuk, M., Nishijima, K., Noda, K., Nosek, D., Nozaki, S., O'Brien, P., Ohira, Y., Ohishi, M., Oka, T., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Osborne, J. P., Ostrowski, M., Oya, I., Pagliaro, A., Palatka, M., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pavleti??, L., Pe'Er, A., Pech, M., Pecimotika, M., Peresano, M., Persic, M., Petruk, O., Pfrang, K., Piatteli, P., Pietropaolo, E., Pillera, R., Pilszyk, B., Pimentel, D., Pintore, F., Pita, S., Pohl, M., Poireau, V., Polo, M., Prado, R. R., Prast, J., Principe, G., Produit, N., Prokoph, H., Prouza, M., Przybilski, H., Pueschel, E., P??hlhofer, G., Pumo, M. L., Punch, M., Queiroz, F., Quirrenbach, A., Rando, R., Razzaque, S., Rebert, E., Recchia, S., Reichherzer, P., Reimer, O., Reimer, A., Renier, Y., Reposeur, T., Rhode, W., Ribeiro, D., Rib??, M., Richtler, T., Rico, J., Rieger, F., Rizi, V., Rodriguez, J., Rodriguez Fernandez, G., Rodriguez Ramirez, J. C., Rodr??guez V??zquez, J. J., Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rosales de Leon, A., Rowell, G., Rudak, B., Rujopakarn, W., Russo, F., Sadeh, I., Saha, L., Saito, T., Salesa Greus, F., Sanchez, D., S??nchez-Conde, M., Sangiorgi, P., Sano, H., Santander, M., Santos, E. M., Sanuy, A., Sarkar, S., Saturni, F. G., Sawangwit, U., Scherer, A., Schleicher, B., Schovanek, P., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Seglar Arroyo, M., Sergijenko, O., Servillat, M., Seweryn, K., Shalchi, A., Sharma, P., Shellard, R. C., Siejkowski, H., Sinha, A., Sliusar, V., Slowikowska, A., Sokolenko, A., Sol, H., Specovius, A., Spencer, S., Spiga, D., Stamerra, A., Stani??, S., Starling, R., Stolarczyk, T., Straumann, U., Stri??kovi??, J., Suda, Y., wierk, P., Tagliaferri, G., Takahashi, H., Takahashi, M., Tavecchio, F., Taylor, L., Tejedor, L. A., Temnikov, P., Terrier, R., Terzic, T., Testa, V., Tian, W., Tibaldo, L., Tonev, D., Torres, D. F., Torresi, E., Tosti, L., Tothill, N., Tovmassian, G., Travnicek, P., Truzzi, S., Tuossenel, F., Umana, G., Vacula, M., Vagelli, V., Valentino, M., Vallage, B., Vallania, P., van Eldik, C., Varner, G. S., Vassiliev, V., V??zquez Acosta, M., Vecchi, M., Veh, J., Vercellone, S., Vergani, S., Verguilov, V., Vettolani, G. P., Viana, A., Vigorito, C. F., Vitale, V., Vorobiov, S., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., Watson, J., White, M., White, R., Wiemann, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Wolter, A., Yamazaki, R., Yanagita, S., Yang, L., Yoshikoshi, T., Zacharias, M., Zaharijas, G., Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., ivec, M., Comisión Nacional de Investigación Científica y Tecnológica (Chile), Ministry of Education, Youth and Sports (Czech Republic), Academy of Finland, Istituto Nazionale di Astrofisica, National Science Centre (Poland), Slovenian Research Agency, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CTA, UAM. Departamento de Física Teórica, Batista, R. A., Anguner, E. O., Ascasibar, Y., Larriva, A. B., Martins, V. B., De Almeida, U. B., Gonzalez, J. B., Tjus, J. B., Arbeletche, L. B., Bottcher, M., Angelis, A. D., De Lavergne, M. D. B., Caprio, V. D., De Dos Anjos, R. C., De Gouveia Dal Pino, E. M., Lotto, B. D., Martino, D. D., De Naurois, M., Wilhelmi, E. D. O., DE PALMA, F., De Souza, V., Ceca, R. D., Volpe, D. D., Girolamo, T. D., Pierro, F. D., Diaz, C., Diaz-Bahamondes, C., Djannati-Atai, A., Dominguez, A., Elsasser, D., Coromina, L. F., Gonzalez, J. M., Collado, T. H., Cadena, S. H., Horandel, J., Hutten, M., Martinez, I. J., Khelifi, B., Knodlseder, J., Palombara, N. L., Lopez, M., Lopez-Coto, R., Manico, G., Marti, J., Martinez, M., Martinez, G., Martinez-Huerta, H., Miranda, D. M., Merino, J. M., Pavletic, L., Puhlhofer, G., Ribo, M., Fernandez, G. R., Ramirez, J. C. R., Vazquez, J. J. R., De Leon, A. R., Greus, F. S., Sanchez-Conde, M., Arroyo, M. S., Stanic, S., Striskovic, J., Swierk, P., Eldik, C. V., Acosta, M. V., Zivec, M., Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Abdalla H., Abe H., Acero F., Acharyya A., Adam R., Agudo I., Aguirre-Santaella A., Alfaro R., Alfaro J., Alispach C., Aloisio R., Batista R.A., Amati L., Amato E., Ambrosi G., Anguner E.O., Araudo A., Armstrong T., Arqueros F., Arrabito L., Asano K., Ascasibar Y., Ashley M., Backes M., Balazs C., Balbo M., Balmaverde B., Larriva A.B., Martins V.B., Barkov M., Baroncelli L., De Almeida U.B., Barrio J.A., Batista P.-I., Gonzalez J.B., Becherini Y., Beck G., Tjus J.B., Belmont R., Benbow W., Bernardini E., Berti A., Berton M., Bertucci B., Beshley V., Bi B., Biasuzzi B., Biland A., Bissaldi E., Biteau J., Blanch O., Bocchino F., Boisson C., Bolmont J., Bonanno G., Arbeletche L.B., Bonnoli G., Bordas P., Bottacini E., Bottcher M., Bozhilov V., Bregeon J., Brill A., Brown A.M., Bruno P., Bruno A., Bulgarelli A., Burton M., Buscemi M., Caccianiga A., Cameron R., Capasso M., Caprai M., Caproni A., Capuzzo-Dolcetta R., Caraveo P., Carosi R., Carosi A., Casanova S., Cascone E., Cauz D., Cerny K., Cerruti M., Chadwick P., Chaty S., Chen A., Chernyakova M., Chiaro G., Chiavassa A., Chytka L., Conforti V., Conte F., Contreras J.L., Coronado-Blazquez J., Cortina J., Costa A., Costantini H., Covino S., Cristofari P., Cuevas O., D'Ammando F., Daniel M.K., Davies J., Dazzi F., Angelis A.D., De Lavergne M.D.B., Caprio V.D., De Dos Anjos R.C., De Gouveia Dal Pino E.M., Lotto B.D., Martino D.D., De Naurois M., Wilhelmi E.D.O., Palma F.D., De Souza V., Delgado C., Ceca R.D., Volpe D.D., Depaoli D., Girolamo T.D., Pierro F.D., Diaz C., Diaz-Bahamondes C., Diebold S., Djannati-Atai A., Dmytriiev A., Dominguez A., Donini A., Dorner D., Doro M., Dournaux J., Dwarkadas V.V., Ebr J., Eckner C., Einecke S., Ekoume T.R.N., Elsasser D., Emery G., Evoli C., Fairbairn M., Falceta-Goncalves D., Fegan S., Feng Q., Ferrand G., Fiandrini E., Fiasson A., Fioretti V., Foffano L., Fonseca M.V., Font L., Fontaine G., Franco F.J., Coromina L.F., Fukami S., Fukazawa Y., Fukui Y., Gaggero D., Galanti G., Gammaldi V., Garcia E., Garczarczyk M., Gascon D., Gaug M., Gent A., Ghalumyan A., Ghirlanda G., Gianotti F., Giarrusso M., Giavitto G., Giglietto N., Giordano F., Glicenstein J., Goldoni P., Gonzalez J.M., Gourgouliatos K., Grabarczyk T., Grandi P., Granot J., Grasso D., Green J., Grube J., Gueta O., Gunji S., Halim A., Harvey M., Collado T.H., Hayashi K., Heller M., Cadena S.H., Hervet O., Hinton J., Hiroshima N., Hnatyk B., Hnatyk R., Hoffmann D., Hofmann W., Holder J., Horan D., Horandel J., Horvath P., Hovatta T., Hrabovsky M., Hrupec D., Hughes G., Hutten M., Iarlori M., Inada T., Inoue S., Insolia A., Ionica M., Iori M., Jacquemont M., Jamrozy M., Janecek P., Martinez I.J., Jin W., Jung-Richardt I., Jurysek J., Kaaret P., Karas V., Karkar S., Kawanaka N., Kerszberg D., Khelifi B., Kissmann R., Knodlseder J., Kobayashi Y., Kohri K., Komin N., Kong A., Kosack K., Kubo H., Palombara N.L., Lamanna G., Lang R.G., Lapington J., Laporte P., Lefaucheur J., Lemoine-Goumard M., Lenain J., Leone F., Leto G., Leuschner F., Lindfors E., Lloyd S., Lohse T., Lombardi S., Longo F., Lopez A., Lopez M., Lopez-Coto R., Loporchio S., Lucarelli F., Luque-Escamilla P.L., Lyard E., Maggio C., Majczyna A., Makariev M., Mallamaci M., Mandat D., Maneva G., Manganaro M., Manico G., Marcowith A., Marculewicz M., Markoff S., Marquez P., Marti J., Martinez O., Martinez M., Martinez G., Martinez-Huerta H., Maurin G., Mazin D., Mbarubucyeye J.D., Miranda D.M., Meyer M., Micanovic S., Miener T., Minev M., Miranda J.M., Mitchell A., Mizuno T., Mode B., Moderski R., Mohrmann L., Molina E., Montaruli T., Moralejo A., Merino J.M., Morcuende-Parrilla D., Morselli A., Mukherjee R., Mundell C., Murach T., Muraishi H., Nagai A., Nakamori T., Nemmen R., Niemiec J., Nieto D., Nievas M., Nikolajuk M., Nishijima K., Noda K., Nosek D., Nozaki S., O'Brien P., Ohira Y., Ohishi M., Oka T., Ong R.A., Orienti M., Orito R., Orlandini M., Orlando E., Osborne J.P., Ostrowski M., Oya I., Pagliaro A., Palatka M., Paneque D., Pantaleo F.R., Paredes J.M., Parmiggiani N., Patricelli B., Pavletic L., Pe'Er A., Pech M., Pecimotika M., Peresano M., Persic M., Petruk O., Pfrang K., Piatteli P., Pietropaolo E., Pillera R., Pilszyk B., Pimentel D., Pintore F., Pita S., Pohl M., Poireau V., Polo M., Prado R.R., Prast J., Principe G., Produit N., Prokoph H., Prouza M., Przybilski H., Pueschel E., Puhlhofer G., Pumo M.L., Punch M., Queiroz F., Quirrenbach A., Rando R., Razzaque S., Rebert E., Recchia S., Reichherzer P., Reimer O., Reimer A., Renier Y., Reposeur T., Rhode W., Ribeiro D., Ribo M., Richtler T., Rico J., Rieger F., Rizi V., Rodriguez J., Fernandez G.R., Ramirez J.C.R., Vazquez J.J.R., Romano P., Romeo G., Roncadelli M., Rosado J., De Leon A.R., Rowell G., Rudak B., Rujopakarn W., Russo F., Sadeh I., Saha L., Saito T., Greus F.S., Sanchez D., Sanchez-Conde M., Sangiorgi P., Sano H., Santander M., Santos E.M., Sanuy A., Sarkar S., Saturni F.G., Sawangwit U., Scherer A., Schleicher B., Schovanek P., Schussler F., Schwanke U., Sciacca E., Scuderi S., Arroyo M.S., Sergijenko O., Servillat M., Seweryn K., Shalchi A., Sharma P., Shellard R.C., Siejkowski H., Sinha A., Sliusar V., Slowikowska A., Sokolenko A., Sol H., Specovius A., Spencer S., Spiga D., Stamerra A., Stanic S., Starling R., Stolarczyk T., Straumann U., Striskovic J., Suda Y., Swierk P., Tagliaferri G., Takahashi H., Takahashi M., Tavecchio F., Taylor L., Tejedor L.A., Temnikov P., Terrier R., Terzic T., Testa V., Tian W., Tibaldo L., Tonev D., Torres D.F., Torresi E., Tosti L., Tothill N., Tovmassian G., Travnicek P., Truzzi S., Tuossenel F., Umana G., Vacula M., Vagelli V., Valentino M., Vallage B., Vallania P., Eldik C.V., Varner G.S., Vassiliev V., Acosta M.V., Vecchi M., Veh J., Vercellone S., Vergani S., Verguilov V., Vettolani G.P., Viana A., Vigorito C.F., Vitale V., Vorobiov S., Vovk I., Vuillaume T., Wagner S.J., Walter R., Watson J., White M., White R., Wiemann R., Wierzcholska A., Will M., Williams D.A., Wischnewski R., Wolter A., Yamazaki R., Yanagita S., Yang L., Yoshikoshi T., Zacharias M., Zaharijas G., Zaric D., Zavrtanik M., Zavrtanik D., Zdziarski A.A., Zech A., Zechlin H., Zhdanov V.I., Zivec M., ITA, USA, GBR, FRA, DEU, ESP, AUS, BRA, BGR, CHL, HRV, FIN, JPN, IRL, MEX, NAM, NLD, POL, CZE, SVN, SWE, CHE, UKR, Astronomy, High Energy Astrophys. & Astropart. Phys (API, FNWI), and Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Gamma ray Astronomy, Cherenkov Telescope Array, axions, MATÉRIA ESCURA, redshift: dependence, Astronomy, Gamma ray experiments, gamma ray experiments, Astrophysics, 01 natural sciences, Cosmology, Observatory, cosmological model: parameter space, gamma ray experiment, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Physics, Cherenkov telescopes, IACT technique, Gamma rays, Cosmic rays, new physics, 4. Education, Settore FIS/01 - Fisica Sperimentale, Astrophysics::Instrumentation and Methods for Astrophysics, Gamma-ray astronomy, violation: Lorentz, 3. Good health, observatory, Extragalactic background light, astro-ph.CO, axion-like particles, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, gamma ray: propagation, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Active galactic nucleus, Axions, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, invariance: Lorentz, jet: relativistic, dark matter: halo, 0103 physical sciences, active galactic nuclei, extragalactic magnetic fields, AGN, Blazar, background, 010308 nuclear & particles physics, Física, Astronomy and Astrophysics, sensitivity, axion, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], absorption, statistical, Blazars, Telescopes
Abstract: Full list of authors: Abdalla, H.; Abe, H.; Acero, F.; Acharyya, A.; Adam, R.; Agudo, I; Aguirre-Santaella, A.; Alfaro, R.; Alfaro, J.; Alispach, C.; Aloisio, R.; Batista, R. Alves; Amati, L.; Amato, E.; Ambrosi, G.; Anguner, E. O.; Araudo, A.; Armstrong, T.; Arqueros, F.; Arrabito, L.; Asano, K.; Ascasibar, Y.; Ashley, M.; Backes, M.; Balazs, C.; Balbo, M.; Balmaverde, B.; Baquero Larriva, A.; Martins, V. Barbosa; Barkov, M.; Baroncelli, L.; de Almeida, U. Barres; Barrio, J. A.; Batista, P-, I; Becerra Gonzalez, J.; Becherini, Y.; Beck, G.; Tjus, J. Becker; Belmont, R.; Benbow, W.; Bernardini, E.; Berti, A.; Berton, M.; Bertucci, B.; Beshley, V; Bi, B.; Biasuzzi, B.; Biland, A.; Bissaldi, E.; Biteau, J.; Blanch, O.; Bocchino, F.; Boisson, C.; Bolmont, J.; Bonanno, G.; Arbeletche, L. Bonneau; Bonnoli, G.; Bordas, P.; Bottacini, E.; Bottcher, M.; Bozhilov, V; Bregeon, J.; Brill, A.; Brown, A. M.; Bruno, P.; Bruno, A.; Bulgarelli, A.; Burton, M.; Buscemi, M.; Caccianiga, A.; Cameron, R.; Capasso, M.; Caprai, M.; Caproni, A.; Capuzzo-Dolcetta, R.; Caraveo, P.; Carosi, R.; Carosi, A.; Casanova, S.; Cascone, E.; Cauz, D.; Cerny, K.; Cerruti, M.; Chadwick, P.; Chaty, S.; Chen, A.; Chernyakova, M.; Chiaro, G.; Chiavassa, A.; Chytka, L.; Conforti, V; Conte, F.; Contreras, J. L.; Coronado-Blazquez, J.; Cortina, J.; Costa, A.; Costantini, H.; Covino, S.; Cristofari, P.; Cuevas, O.; D'Ammando, F.; Daniel, M. K.; Davies, J.; Dazzi, F.; De Angelis, A.; de Lavergne, M. de Bony; De Caprio, V; dos Anjos, R. de Cassia; Dal Pino, E. M. de Gouveia; De Lotto, B.; De Martino, D.; de Naurois, M.; Wilhelmi, E. de Ona; De Palma, F.; de Souza, V; Delgado, C.; Della Ceca, R.; della Volpe, D.; Depaoli, D.; Di Girolamo, T.; Di Pierro, F.; Diaz, C.; Diaz-Bahamondes, C.; Diebold, S.; Djannati-Atai, A.; Dmytriiev, A.; Dominguez, A.; Donini, A.; Dorner, D.; Doro, M.; Dournaux, J.; Dwarkadas, V. V.; Ebr, J.; Eckner, C.; Einecke, S.; Ekoume, T. R. N.; Elsaesser, D.; Emery, G.; Evoli, C.; Fairbairn, M.; Falceta-Goncalves, D.; Fegan, S.; Feng, Q.; Ferrand, G.; Fiandrini, E.; Fiasson, A.; Fioretti, V; Foffano, L.; Fonseca, M., V; Font, L.; Fontaine, G.; Franco, F. J.; Freixas Coromina, L.; Fukami, S.; Fukazawa, Y.; Fukui, Y.; Gaggero, D.; Galanti, G.; Gammaldi, V; Garcia, E.; Garczarczyk, M.; Gascon, D.; Gaug, M.; Gent, A.; Ghalumyan, A.; Ghirlanda, G.; Gianotti, F.; Giarrusso, M.; Giavitto, G.; Giglietto, N.; Giordano, F.; Glicenstein, J.; Goldoni, P.; Gonzalez, J. M.; Gourgouliatos, K.; Grabarczyk, T.; Grandi, P.; Granot, J.; Grasso, D.; Green, J.; Grube, J.; Gueta, O.; Gunji, S.; Halim, A.; Harvey, M.; Collado, T. Hassan; Hayashi, K.; Heller, M.; Cadena, S. Hernandez; Hervet, O.; Hinton, J.; Hiroshima, N.; Hnatyk, B.; Hnatyk, R.; Hoffmann, D.; Hofmann, W.; Holder, J.; Horan, D.; Horandel, J.; Horvath, P.; Hovatta, T.; Hrabovsky, M.; Hrupec, D.; Hughes, G.; Hutten, M.; Iarlori, M.; Inada, T.; Inoue, S.; Insolia, A.; Ionica, M.; Iori, M.; Jacquemont, M.; Jamrozy, M.; Janecek, P.; Jimenez Martinez, I; Jin, W.; Jung-Richardt, I; Jurysek, J.; Kaaret, P.; Karas, V; Karkar, S.; Kawanaka, N.; Kerszberg, D.; Khelifi, B.; Kissmann, R.; Knodlseder, J.; Kobayashi, Y.; Kohri, K.; Komin, N.; Kong, A.; Kosack, K.; Kubo, H.; La Palombara, N.; Lamanna, G.; Lang, R. G.; Lapington, J.; Laporte, P.; Lefaucheur, J.; Lemoine-Goumard, M.; Lenain, J.; Leone, F.; Leto, G.; Leuschner, F.; Lindfors, E.; Lloyd, S.; Lohse, T.; Lombardi, S.; Longo, F.; Lopez, A.; Lopez, M.; Lopez-Coto, R.; Loporchio, S.; Lucarelli, F.; Luque-Escamilla, P. L.; Lyard, E.; Maggio, C.; Majczyna, A.; Makariev, M.; Mallamaci, M.; Mandat, D.; Maneva, G.; Manganaro, M.; Manico, G.; Marcowith, A.; Marculewicz, M.; Markoff, S.; Marquez, P.; Marti, J.; Martinez, O.; Martinez, M.; Martinez, G.; Martinez-Huerta, H.; Maurin, G.; Mazin, D.; Mbarubucyeye, J. D.; Miranda, D. Medina; Meyer, M.; Micanovic, S.; Miener, T.; Minev, M.; Miranda, J. M.; Mitchell, A.; Mizuno, T.; Mode, B.; Moderski, R.; Mohrmann, L.; Molina, E.; Montaruli, T.; Moralejo, A.; Morales Merino, J.; Morcuende-Parrilla, D.; Morselli, A.; Mukherjee, R.; Mundell, C.; Murach, T.; Muraishi, H.; Nagai, A.; Nakamori, T.; Nemmen, R.; Niemiec, J.; Nieto, D.; Nievas, M.; Nikolajuk, M.; Nishijima, K.; Noda, K.; Nosek, D.; Nozaki, S.; Ohira, Y.; Ohishi, M.; Oka, T.; Ong, R. A.; Orienti, M.; Orito, R.; Orlandini, M.; Orlando, E.; Osborne, J. P.; Ostrowski, M.; Oya, I; Pagliaro, A.; Palatka, M.; Paneque, D.; Pantaleo, F. R.; Paredes, J. M.; Parmiggiani, N.; Patricelli, B.; Pavletic, L.; Pe'er, A.; Pech, M.; Pecimotika, M.; Peresano, M.; Persic, M.; Petruk, O.; Pfrang, K.; Piatteli, P.; Pietropaolo, E.; Pillera, R.; Pilszyk, B.; Pimentel, D.; Pintore, F.; Pita, S.; Pohl, M.; Poireau, V; Polo, M.; Prado, R. R.; Prast, J.; Principe, G.; Produit, N.; Prokoph, H.; Prouza, M.; Przybilski, H.; Pueschel, E.; Puehlhofer, G.; Pumo, M. L.; Punch, M.; Queiroz, F.; Quirrenbach, A.; Rando, R.; Razzaque, S.; Rebert, E.; Recchia, S.; Reichherzer, P.; Reimer, O.; Reimer, A.; Renier, Y.; Reposeur, T.; Rhode, W.; Ribeiro, D.; Ribo, M.; Richtler, T.; Rico, J.; Rieger, F.; Rizi, V; Rodriguez, J.; Fernandez, G. Rodriguez; Ramirez, J. C. Rodriguez; Rodriguez Vazquez, J. J.; Romano, P.; Romeo, G.; Roncadelli, M.; Rosado, J.; de Leon, A. Rosales; Rowell, G.; Rudak, B.; Rujopakarn, W.; Russo, F.; Sadeh, I; Saha, L.; Saito, T.; Greus, F. Salesa; Sanchez, D.; Sanchez-Conde, M.; Sangiorgi, P.; Sano, H.; Santander, M.; Santos, E. M.; Sanuy, A.; Sarkar, S.; Saturni, F. G.; Sawangwit, U.; Scherer, A.; Schleicher, B.; Schovanek, P.; Schussler, F.; Schwanke, U.; Sciacca, E.; Scuderi, S.; Arroyo, M. Seglar; Sergijenko, O.; Servillat, M.; Seweryn, K.; Shalchi, A.; Sharma, P.; Shellard, R. C.; Siejkowski, H.; Sinha, A.; Sliusar, V; Slowikowska, A.; Sokolenko, A.; Sol, H.; Specovius, A.; Spencer, S.; Spiga, D.; Stamerra, A.; Starling, R.; Stolarczyk, T.; Straumann, U.; Striskovic, J.; Suda, Y.; Tagliaferri, G.; Takahashi, H.; Takahashi, M.; Tavecchio, F.; Taylor, L.; Tejedor, L. A.; Temnikov, P.; Terrier, R.; Terzic, T.; Testa, V; Tian, W.; Tibaldo, L.; Tonev, D.; Torres, D. F.; Torresi, E.; Tosti, L.; Tothill, N.; Tovmassian, G.; Travnicek, P.; Truzzi, S.; Tuossenel, F.; Umana, G.; Vacula, M.; Vagelli, V.; Valentino, M.; Vallage, B.; Vallania, P.; van Eldik, C.; Varner, G. S.; Vassiliev, V.; Vazquez Acosta, M.; Vecchi, M.; Veh, J.; Vercellone, S.; Vergani, S.; Verguilov, V.; Vettolani, G. P.; Viana, A.; Vigorito, C. F.; Vitale, V.; Vorobiov, S.; Vovk, I; Vuillaume, T.; Wagner, S. J.; Walter, R.; Watson, J.; White, M.; White, R.; Wiemann, R.; Wierzcholska, A.; Will, M.; Williams, D. A.; Wischnewski, R.; Wolter, A.; Yamazaki, R.; Yanagita, S.; Yang, L.; Yoshikoshi, T.; Zacharias, M.; Zaharijas, G.; Zaric, D.; Zavrtanik, M.; Zavrtanik, D.; Zdziarski, A. A.; Zech, A.; Zechlin, H.; Zhdanov, V., I; Zivec, M., The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for γ astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of γ cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of γ absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift z=2 and to constrain or detect γ halos up to intergalactic-magnetic-field strengths of at least 0.3 pG . Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from γ astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of γ cosmology. © 2021 IOP Publishing Ltd and Sissa Medialab., We gratefully acknowledge financial support from the following agencies and organizations: State Committee of Science of Armenia, Armenia; The Australian Research Council, Astronomy Australia Ltd, The University of Adelaide, Australian National University, Monash University, The University of New South Wales, The University of Sydney, Western Sydney University, Australia; Federal Ministry of Education, Science and Research, and Innsbruck University, Austria; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Ministry of Science, Technology, Innovations and Communications (MCTIC), Brasil; Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, Bulgaria; The Natural Sciences and Engineering Research Council of Canada and the Canadian Space Agency, Canada; CONICYT-Chile grants CATA AFB 170002, ANID PIA/APOYO AFB 180002, ACT 1406, FONDECYT-Chile grants, 1161463, 1170171, 1190886, 1171421, 1170345, 1201582, Gemini-ANID 32180007, Chile; Croatian Science Foundation, Rudjer Boskovic Institute, University of Osijek, University of Rijeka, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, University of Zagreb, Faculty of Electrical Engineering and Computing, Croa tia; Ministry of Education, Youth and Sports, MEYS M2015046, LM2018105, LTT17006, EU/MEYS CZ.02.1.01/0.0/0.0/16_013/0001403, CZ.02.1.01/0.0/0.0/18_046/0016007 and CZ.02.1.01/0.0/0.0/16_019/0000754, Czech Republic; Academy of Finland (grant nr.317636 and 320045), Finland; Ministry of Higher Education and Research, CNRS-INSU and CNRS-IN2P3, CEA-Irfu, ANR, Regional Council Ile de France, Labex ENIGMASS, OCEVU, OSUG2020 and P2IO, France; Max Planck Society, BMBF, DESY, Helmholtz Association, Germany; Department of Atomic Energy, Department of Science and Technology, India; Istituto Nazionale di Astrofisica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), MIUR, Istituto Nazionale di Astrofisica (INAF-OABRERA) Grant Fondazione Cariplo/Regione Lombardia ID 2014-1980/RST_ERC, Italy; ICRR, University of Tokyo, JSPS, MEXT, Japan; Netherlands Research School for Astronomy (NOVA), Netherlands Organization for Scientific Research (NWO), Netherlands; University of Oslo, Norway; Ministry of Science and Higher Education, DIR/WK/2017/12, the National Centre for Research and Development and the National Science Centre, UMO-2016/22/M/ST9/00583, Poland; Slovenian Research Agency, grants P1-0031, P1-0385, I0-0033, J1-9146, J1-1700, N1-0111, and the Young Researcher program, Slovenia; South African Department of Science and Technology and National Research Foundation through the South African Gamma-Ray Astronomy Programme, South Africa; The Spanish groups acknowledge the Spanish Ministry of Science and Innovation and the Spanish Research State Agency (AEI) through grants AYA2016-79724-C4-1-P, AYA2016-80889-P, AYA2016-76012-C3-1-P, BES-2016-076342, FPA2017-82729-C6-1-R, FPA2017-82729-C6-2-R, FPA2017-82729-C6-3-R, FPA2017-82729-C6-4-R, FPA2017-82729-C6-5-R, FPA2017-82729-C6-6-R, PGC2018-095161-B-I00, PGC2018-095512-B-I00, PID2019-107988GB-C22; the “Centro de Excelencia Severo Ochoa” program through grants no. SEV-2016-0597, SEV-2016-0588, SEV-2017-0709, CEX2019-000920-S; the “Unidad de Excelencia María de Maeztu” program through grant no. MDM-2015-0509; the “Ramón y Cajal” programme through grants RYC-2013-14511, RYC-2017-22665; and the MultiDark Consolider Network FPA2017-90566-REDC. They also acknowledge the Atracción de Talento contract no. 2016-T1/TIC-1542 granted by the Comunidad de Madrid; the “Postdoctoral Junior Leader Fellowship” programme from La Caixa Bank ing Foundation, grants no. LCF/BQ/LI18/11630014 and LCF/BQ/PI18/11630012; the “Programa Operativo” FEDER 2014-2020, Consejería de Economía y Conocimiento de la Junta de Andalucía (Ref. 1257737), PAIDI 2020 (Ref. P18-FR-1580) and Universidad de Jaén; “Programa Operativo de Crecimiento Inteligente” FEDER 2014-2020 (Ref. ESFRI-2017-IAC-12), Ministerio de Ciencia e Innovación, 15% co-financed by Consejería de Economía, Industria, Comercio y Conocimiento del Gobierno de Canarias; the Spanish AEI EQC2018-005094-P FEDER 2014-2020; the European Union’s “Horizon 2020” research and innovation programme under Marie Skłodowska-Curie grant agreement no. 665919; and the ESCAPE project with grant no. GA:824064; Swedish Research Council, Royal Physiographic Society of Lund, Royal Swedish Academy of Sciences, The Swedish National Infrastructure for Computing (SNIC) at Lunarc (Lund), Sweden; State Secretariat for Education, Research and Innovation (SERI) and Swiss National Science Foundation (SNSF), Switzerland; Durham University, Leverhulme Trust, Liverpool University, University of Leicester, University of Oxford, Royal Soci ety, Science and Technology Facilities Council, UK; U.S. National Science Foundation, U.S. Department of Energy, Argonne National Laboratory, Barnard College, University of California, University of Chicago, Columbia University, Georgia Institute of Technology, Institute for Nuclear and Particle Astrophysics (INPAC-MRPI program), Iowa State University, the Smithsonian Institution, Washington University McDonnell Center for the Space Sciences, The University of Wisconsin and the Wisconsin Alumni Research Foundation, USA. The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreements No 262053 and No 317446. This project is receiving funding from the European Union’s Horizon 2020 research and innovation programs under agreement No 676134. The research leading to these results has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement GammaRayCascades No 843800. The Fermi LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat à l’Energie Atomique and the Centre National de la Recherche Scientifique / Institut National de Physique Nucléaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d’Études Spatiales in France. This work performed in part under DOE Contract DE-AC02-76SF00515.
Published: 2021

30. Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

Author: Masanori Nakamura, R. Shang, Abelardo Moralejo, A. Rugliancich, Marina Manganaro, Jun Liu, Monika Moscibrodzka, Andreas Specovius, V. Ramakrishnan, S. O'Brien, Michal Ostrowski, Luis C. Ho, Sera Markoff, D. Depaoli, I. Jung-Richardt, Manel Errando, Chiara Righi, S. Panny, Toshiaki Inada, Alexandra J. Tetarenko, Daniela Dorner, Norbert Wex, Nimesh A. Patel, Olivier Hervet, C. Arcaro, Alasdair E. Gent, Yu Wun Wong, Gaia Vanzo, Pierre Brun, Konstancja Satalecka, Stefan Funk, Lorenzo Bellizzi, Michael Lindqvist, Michele Doro, Felix Jankowsky, P. Kaaret, Nicholas R. MacDonald, Lang Cui, P. Temnikov, S. Patel, Sabrina Einecke, Manuel Artero, E. Moretti, Hope Boyce, M. Gaug, Charles F. Gammie, Iryna Lypova, Gisela N. Ortiz-León, Felix Aharonian, Colin J. Lonsdale, Buell T. Jannuzi, Gavin Rowell, M. Bryan, Yvonne Becherini, Aleksandar Popstefanija, M. Pohl, A. Marcowith, Jean-Pierre Ernenwein, H. Alyson Ford, Wystan Benbow, Karen E. Williamson, Daryl Haggard, Hambeleleni Ndiyavala, Tod R. Lauer, Arnaud Mares, Chaitanya Priyadarshi, Michael Punch, Helge Rottmann, J. Zorn, D. Dominis Prester, Bernd Schleicher, M. Minev, Hector Olivares, Ciriaco Goddi, S. Pita, J. Herrera, Alessia Spolon, Léa Jouvin, Na Wang, G. Martí-Devesa, Tomohiko Oka, Kirsty Feijen, E. Do Souto Espiñeira, Ralph Eatough, Johannes Veh, Stefano Gabici, Tomislav Terzić, D. Glawion, Gilles Fontaine, Bradford Benson, C. B. Rulten, Jenni Jormanainen, Jason SooHoo, Michael Titus, Jose Miguel Delgado, Marcos López-Moya, Freek Roelofs, Wlodek Bednarek, M. Lundy, Richard Anantua, Alessandra Lamastra, P. T. Reynolds, Vassil Verguilov, M. Lemoine-Goumard, G. Fichet de Clairfontaine, L. Di Venere, Michael Kreter, Jose Miguel Miranda, Alan L. Roy, Yating Chai, A. López-Oramas, M. Tluczykont, Jacek Niemiec, R. Konno, Tyler Trent, Olaf Reimer, Heino Falcke, Amanpreet Kaur, M. Panter, Narek Sahakyan, Kasper B. Schmidt, A. Carosi, K. Egberts, L. Maraschi, Stefan Cikota, V. Joshi, Koji Noda, Elisa Bernardini, Ye-Fei Yuan, Garrett K. Keating, Fumie Tazaki, Pawel Gliwny, M. Vazquez Acosta, Nicola Giglietto, M. Capasso, Vincent Piétu, Satoshi Fukami, Roman Gold, Elina Lindfors, Satoki Matsushita, A. Lemiere, F. Eichhorn, U. Katz, Yoshinori Yonekura, N. Shafi, Natalia Żywucka, Michael Kramer, M. Palatiello, Daniel Mazin, Samuel Timothy Spencer, Victoria Moreno, Oliver Porth, Julian Sitarek, Kazi L.J. Rygl, Wen Ping Lo, Geoffrey C. Bower, Ilje Cho, S. Fegan, Samuel Zouari, J. M. Paredes, V. Fallah Ramazani, Thomas Murach, Jim Hinton, R. J. White, F. Leone, S. Loporchio, M. de Naurois, Ed Fomalont, Bart Ripperda, Dominique Broguiere, J. Becerra González, Joseph R. Farah, Q. Feng, Andreas Quirrenbach, Taehyun Jung, C. Trichard, Masahiro Teshima, Domenico Tiziani, D. Malyshev, Richard Plambeck, Lynn D. Matthews, Avery E. Broderick, S. Kumar, T. J. Williamson, M. K. Daniel, Sylvia Zhu, P. J. Meintjes, Tjark Miener, Jodi Christiansen, Roger Brissenden, S. Sailer, Dmitry Khangulyan, David Paneque, Thomas P. Krichbaum, Sergey S. Savchenko, Angelo Ricarte, Riaan Steenkamp, T. Chand, J. Dyks, Francesco Dazzi, V. Baghmanyan, Zorawar Wadiasingh, Kazunori Akiyama, Stefan Ohm, C. Levy, Giovanna Ferrara, Makoto Inoue, Jhilik Majumdar, Nobuyuki Sakai, Dieter Horns, Jorge A. Preciado-López, Cornelia Müller, G. Hermann, Regis Terrier, A. J. Chromey, Dominic W. Pesce, Felix M. Pötzl, Mark Gurwell, Alejandro Cruz-Osorio, Ivan Marti-Vidal, Ben Prather, Tom Armstrong, Jongho Park, Matteo Cerruti, Ziri Younsi, Amy Furniss, Chih-Wei Locutus Huang, Lijing Shao, A. Djannati-Ataï, Shoko Koyama, D. Gottschall, P. Vincent, A. Brill, Kenji Toma, Antonios Nathanail, M. Nievas-Rosillo, M. Seglar-Arroyo, C. Delgado Mendez, Mahito Sasada, G. Busetto, Maciek Wielgus, Marcos Santander, Doosoo Yoon, D. A. Sanchez, Hiroki Okino, Christo Venter, Christiaan D. Brinkerink, James Ryan, S. Mićanović, Raquel Fraga-Encinas, Mark G. Rawlings, G. H. Sembroski, G. Principe, Xiang Liu, Karl Friedrich Schuster, Ronald Hesper, L. Sun, Ciro Bigongiari, Ramesh Narayan, M. Strzys, L. Mohrmann, Daniel R. van Rossum, Y. Ohtani, Wu Jiang, Luciano Rezzolla, Nu. Komin, V. A. Acciari, Katherine L. Bouman, Jürgen Besenrieder, Clemens Hoischen, A. A. Zdziarski, Antonio Tutone, Hung Yi Pu, A. Arbet Engels, J.-P. Lenain, A. De Angelis, Tomoya Hirota, R. J. García López, Carlo Romoli, Werner Hofmann, Tuomas Savolainen, Neil M. Nagar, Minfeng Gu, M. Karjalainen, Vitaly Neustroev, A. N. Otte, John F. C. Wardle, Tomoaki Oyama, Jongsoo Kim, Monica Barnard, J. Otero-Santos, R. D. Parsons, Pierre Christian, A. Priyana Noel, A. S. Seyffert, Shami Chatterjee, E. O. Angüner, David A. Green, Ramesh Karuppusamy, Zhiyuan Li, J. Devin, Dominik Elsaesser, F. Giordano, Santiago Ubach, Michael A. Nowak, Y. Kobayashi, F. Di Pierro, Iniyan Natarajan, A. Zech, M. Garczarczyk, Dmitriy Kostunin, Michael Janssen, Giacomo Bonnoli, Mariafelicia De Laurentis, Kuo Liu, G. Emery, Yutaro Kofuji, Antxon Alberdi, Marco Toliman Lucchini, R. A. Ong, Catherine Boisson, Daniel C. M. Palumbo, Stefan Klepser, Stefano Covino, Motoki Kino, Daniel Kerszberg, C. Armand, Maria Haupt, D. Zarić, K. Pfrang, R. López-Coto, M. Zacharias, Jae-Young Kim, Sheperd S. Doeleman, U. Barres de Almeida, Pratik Majumdar, M. V. Fonseca, Mosè Mariotti, G. Lamanna, Alexander Hahn, Sidika Merve Colak, R. J. Tuffs, B. Bi, Juan-Carlos Algaba, L. Oakes, D. Jankowsky, Y. Kajiwara, R. Marx, Bošnjak, John E. Barrett, Kotaro Niinuma, F. D'Ammando, Qingwen Wu, A. Yusafzai, Christian M. Fromm, Chi-kwan Chan, B. De Lotto, M. Kertzman, Manuela Mallamaci, H. Prokoph, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, E. Kasai, Lea Heckmann, Bong Won Sohn, Francesco Gabriele Saturni, Shiro Ikeda, T. Vuillaume, Laurent Loinard, G. Maurin, M. Füßling, Martin Will, Yi Chen, Gianluca Giavitto, Remo P. J. Tilanus, M. Spir-Jacob, Alessandro Montanari, Thomas Lohse, Tihomir Surić, J. van Scherpenberg, Per Friberg, He Sun, Luca Tosti, Kiyoaki Wajima, E. Ruiz-Velasco, Thomas Bylund, M. Balokovic, Feng Yuan, S. Nozaki, Mischa Breuhaus, Peter Galison, Y. A. Gallant, L. Olivera-Nieto, Dorota Sobczyńska, Maria-Isabel Bernardos, R. Rauth, Izumi Mizuno, Vincent L. Fish, S. G. Jorstad, Tomoki Saito, Giovanni Ceribella, Jacques Muller, J. P. Finley, Stefano Ansoldi, Boris Georgiev, Marcello Giroletti, Arturo I. Gómez-Ruiz, Karl M. Menten, Aristeidis Noutsos, P. deWilt, Junhan Kim, Alejandro Mus Mejías, Q. Remy, Dong-Jin Kim, P. G. Prada Moroni, Robert Wharton, Riccardo Paoletti, R. R. Prado, Zhi-Qiang Shen, S. Paiano, S. Chandra, Andrés Baquero, Anna Barnacka, Lucy Fortson, Wrijupan Bhattacharyya, Marc Ribó, E. de Ona Wilhelmi, Paul T. P. Ho, Yan-Rong Li, Derek Ward-Thompson, M. Scalici, G. Maneva, Constantin Steppa, Dimitrios Psaltis, A.M. Taylor, J. Damascene Mbarubucyeye, Daniel P. Marrone, Karl Mannheim, W. Boland, P. Morris, D. A. Prokhorov, M. Mohamed, Katsuaki Asano, Gernot Maier, Kotaro Moriyama, H. Odaka, M. Büchele, E. Pueschel, Kazuyoshi Nishijima, Christopher J. Duffy, H. M. Schutte, Camilla Maggio, Mark Kettenis, V. D'Elia, Saverio Lombardi, Ramprasad Rao, Ivica Puljak, R. Mirzoyan, V. Sahakian, Guang Yao Zhao, Adrian Biland, F. Werner, Rafal Moderski, Olivier Gentaz, Ullrich Schwanke, James M. Moran, S. Komossa, Yuzhu Cui, A. Jiménez-Rosales, Arash Roshanineshat, S. Ventura, Lindy Blackburn, David J. James, G. Hughes, Hidetoshi Kubo, Mansour Karami, José L. Gómez, P. Reichherzer, Davit Zargaryan, Paul Tiede, Koushik Chatterjee, Chunchong Ni, Roger Deane, Axel Donath, J. Rico, A. W. Chen, A. Fiasson, Jun Yi Koay, T. B. Humensky, Satoko Sawada-Satoh, Isak Delberth Davids, Alan P. Marscher, Alan E. E. Rogers, Rebecca Azulay, Kazuma Ishio, Paul M. Chesler, D. 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Nakashima, Alice Donini, David H. Hughes, Heinrich J. Völk, Mohanraj Senniappan, K. A. Farrell, M. Renaud, J. A. Barrio, Miriam Lucio Martinez, Rachel Simoni, P. T. O'Brien, E. Colombo, V. Barbosa Martins, M. Orienti, Efthalia Traianou, Lluis Font, B. Machado de Oliveira Fraga, Y. Suda, J. Neilsen, John Conway, Eduardo Ros, Gibwa Musoke, Tarek M. Hassan, J. Bolmont, A. Sinha, Halim Ashkar, M.-H. Grondin, Daniel Nieto, Lab Saha, Fabrizio Tavecchio, Hyunwook Ro, Michael H. Hecht, Markus Böttcher, Antonio Fuentes, Simone Mender, Moritz Hütten, Ue-Li Pen, Yosuke Mizuno, Gopal Narayanan, Lei Huang, H. Abdalla, M. A. Kastendieck, Nicola Marchili, I. Snidaric, S. Sánchez, G. Vasileiadis, Kari Nilsson, Alexander W. Raymond, Greg Lindahl, Gregory Desvignes, Sascha Trippe, Sanae Inoue, Giacomo D'Amico, W. Jin, B. van Soelen, Andrew Chael, Anne Kathrin Baczko, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Walter Alef, Jamie Holder, Stefano Truzzi, Pablo Peñil, M. J. Lang, Francois Brun, Frank M. 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Katarzyński, Roberto Neri, The EHT MWL Science Working Group, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Instituto de RadioAstronomía Milimétrica (IRAM), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Groupe de Physique des Solides (GPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Event Horizon Telescope, Fermi-LAT, H.E.S.S., MAGIC, VERITAS, EAVN, High Energy Astrophys. & Astropart. Phys (API, FNWI), API Other Research (FNWI), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Algaba, Jc, Anczarski, J, Asada, K, Balokovic, M, Chandra, S, Cui, Yz, Falcone, Ad, Giroletti, M, Goddi, C, Hada, K, Haggard, D, Jorstad, S, Kaur, A, Kawashima, T, Keating, G, Kim, Jy, Kino, M, Komossa, S, Kravchenko, Ev, Krichbaum, Tp, Lee, S, Lu, R, Lucchini, M, Markoff, S, Neilsen, J, Nowak, Ma, Park, J, Principe, G, Ramakrishnan, V, Reynolds, Mt, Sasada, M, Savchenko, S, Williamson, Ke, Longo, F, Et, Al., University of Michigan, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Algaba, J. C., Anczarski, J., Asada, K., Balokovic, M., Chandra, S., Cui, Y. -Z., Falcone, A. D., Giroletti, M., Goddi, C., Hada, K., Haggard, D., Jorstad, S., Kaur, A., Kawashima, T., Keating, G., Kim, J. -Y., Kino, M., Komossa, S., Kravchenko, E. V., Krichbaum, T. P., Lee, S. -S., Lu, R. -S., Lucchini, M., Markoff, S., Neilsen, J., Nowak, M. A., Park, J., Principe, G., Ramakrishnan, V., Reynolds, M. T., Sasada, M., Savchenko, S. S., Williamson, K. E., Akiyama, K., Alberdi, A., Alef, W., Anantua, R., Azulay, R., Baczko, A. -K., Ball, D., Barrett, J., Bintley, D., Benson, B. A., Blackburn, L., Blundell, R., Boland, W., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D. -Y., Carlstrom, J. E., Chael, A., Chan, C. -K., Chatterjee, S., Chatterjee, K., Chen, M. -T., Chen, Y., Chesler, P. M., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Falcke, H., Farah, J., Fish, V. L., Fomalont, E., Ford, H. A., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., Garcia, R., Gentaz, O., Georgiev, B., Gold, R., Gomez, J. L., Gomez-Ruiz, A. I., Gu, M., Gurwell, M., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. -W. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Janssen, M., Jeter, B., Jiang, W., Jimenez-Rosales, A., Johnson, M. D., Jung, T., Karami, M., Karuppusamy, R., Kettenis, M., Kim, D. -J., Kim, J., Koay, J. Y., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Kuo, C. -Y., Lauer, T. R., Levis, A., Li, Y. -R., Li, Z., Lindqvist, M., Lico, R., Lindahl, G., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C., Macdonald, N. R., Mao, J., Marchili, N., Marrone, D. P., Marscher, A. P., Marti-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Moscibrodzka, M., Muller, C., Musoke, G., Mejias, A. M., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Natarajan, I., Nathanail, A., Neri, R., Ni, C., Noutsos, A., Okino, H., Olivares, H., Ortiz-Leon, G. N., Oyama, T., Ozel, F., Palumbo, D. C. M., Patel, N., Pen, U. -L., Pesce, D. W., Pietu, V., Plambeck, R., Popstefanija, A., Porth, O., Potzl, F. M., Prather, B., Preciado-Lopez, J. A., Psaltis, D., Pu, H. -Y., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Rygl, K. L. J., Sanchez, S., Sanchez-Arguelles, D., Savolainen, T., Schloerb, F. P., Schuster, K. -F., Shao, L., Shen, Z., Small, D., Sohn, B. W., Soohoo, J., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Toma, K., Torne, P., Trent, T., Traianou, E., Trippe, S., Van Bemmel, I., Van Langevelde, H. J., Van Rossum, D. R., Wagner, J., Ward-Thompson, D., Wardle, J., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Yoon, D., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y. -F., Zensus, J. A., Zhao, G. -Y., Zhao, S. -S., D'Ammando, F., Orienti, M., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. A., Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlohr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., De Bony De Lavergne, M., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Buchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chen, A., Cotter, G., Curylo, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., De Clairfontaine, G. F., Fontaine, G., Funk, S., Fussling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, N., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., De Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., De Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. P., Prokhorov, D. A., Prokoph, H., Puhlhofer, G., Punch, M., Quirrenbach, A., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., Van Der Walt, D. J., Van Eldik, C., Van Rensburg, C., Van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Volk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Y. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Zywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Artero, M., Asano, K., Baack, D., Babic, A., Baquero, A., De Almeida, U. B., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jimenez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez-Coto, R., Lopez-Moya, M., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Menchiari, S., Mender, S., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Penil, P., Perennes, C., Persic, M., Moroni, P. G. P., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zaric, D., Adams, C. B., Benbow, W., Brill, A., Capasso, M., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Errando, M., Farrell, K. A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Gent, A., Giuri, C., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Jin, W., Kaaret, P., Kertzman, M., Kieda, D., Kumar, S., Lang, M. J., Lundy, M., Maier, G., Moriarty, P., Mukherjee, R., Nieto, D., Nievas-Rosillo, M., O'Brien, S., Ong, R. A., Otte, A. N., Patel, S., Pfrang, K., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Richards, G. T., Roache, E., Rulten, C., Ryan, J. L., Santander, M., Sembroski, G. H., Shang, R., Weinstein, A., Williams, D. A., Williamson, T. J., Hirota, T., Cui, L., Niinuma, K., Ro, H., Sakai, N., Sawada-Satoh, S., Wajima, K., Wang, N., Liu, X., Yonekura, Y., German Research Foundation, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), University of Tokyo, Japan Society for the Promotion of Science, Ministry of Education and Scientific Research (Romania), Academy of Finland, La Caixa, Croatian Science Foundation, Generalitat de Catalunya, Polish National Agency for Academic Exchange, University of Rijeka, Department of Energy (US), Smithsonian Institution, Astronomy, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Accretion, 010504 meteorology & atmospheric sciences, Astronomy, Flux, Astrophysics, 7. Clean energy, 01 natural sciences, Active galactic nuclei, Radio cores, Low-luminosity active galactic nuclei, High energy astrophysics, Astrophysical black holes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, Radio core, Accretion (meteorology), 520 Astronomie und zugeordnete Wissenschaften, Low-luminosity, active galactic nuclei, Astrophysical black hole, astro-ph.CO, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Active galactic nucleus, High-energy astronomy, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, F500, Astrophysics::Cosmology and Extragalactic Astrophysics, High energy astrophysic, 0103 physical sciences, Very-long-baseline interferometry, ddc:530, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Event Horizon Telescope, Supermassive black hole, Astronomy and Astrophysics, 530 Physik, Galaxy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; Benson, Bradford A.; Blackburn, Lindy; Blundell, Raymond; Boland, Wilfred; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope; Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Dominique; Bronzwaer, Thomas; Byun, Do-Young; Carlstrom, John E.; Chael, Andrew; Chan, Chi-Kwan; Chatterjee, Shami; Chatterjee, Koushik; Chen, Ming-Tang; Chen, Yongjun; Chesler, Paul M.; Cho, Ilje; Christian, Pierre; Conway, John E.; Cordes, James M.; Crawford, Thomas M.; Crew, Geoffrey B.; Cruz-Osorio, Alejandro; Davelaar, Jordy; de Laurentis, Mariafelicia; Deane, Roger; Dempsey, Jessica; Desvignes, Gregory; Dexter, Jason; Doeleman, Sheperd S.; Eatough, Ralph P.; Falcke, Heino; Farah, Joseph; Fish, Vincent L.; Fomalont, Ed; Ford, H. Alyson; Fraga-Encinas, Raquel; Friberg, Per; Fromm, Christian M.; Fuentes, Antonio; Galison, Peter; Gammie, Charles F.; García, Roberto; Gentaz, Olivier; Georgiev, Boris; Gold, Roman; Gómez, José L.; Gómez-Ruiz, Arturo I.; Gu, Minfeng; Gurwell, Mark; Hecht, Michael H.; Hesper, Ronald; Ho, Luis C.; Ho, Paul; Honma, Mareki; Huang, Chih-Wei L.; Huang, Lei; Hughes, David H.; Ikeda, Shiro; Inoue, Makoto; Issaoun, Sara; James, David J.; Jannuzi, Buell T.; Janssen, Michael; Jeter, Britton; Jiang, Wu; Jiménez-Rosales, Alejandra; Johnson, Michael D.; Jung, Taehyun; Karami, Mansour; Karuppusamy, Ramesh; Kettenis, Mark; Kim, Dong-Jin; Kim, Jongsoo; Kim, Junhan; Koay, Jun Yi; Kofuji, Yutaro; Koch, Patrick M.; Koyama, Shoko; Kramer, Michael; Kramer, Carsten; Kuo, Cheng-Yu; Lauer, Tod R.; Levis, Aviad; Li, Yan-Rong; Li, Zhiyuan; Lindqvist, Michael; Lico, Rocco; Lindahl, Greg; Liu, Jun; Liu, Kuo; Liuzzo, Elisabetta; Lo, Wen-Ping; Lobanov, Andrei P.; Loinard, Laurent; Lonsdale, Colin; MacDonald, Nicholas R.; Mao, Jirong; Marchili, Nicola; Marrone, Daniel P.; Marscher, Alan P.; Martí-Vidal, Iván; Matsushita, Satoki; Matthews, Lynn D.; Medeiros, Lia; Menten, Karl M.; Mizuno, Izumi; Mizuno, Yosuke; Moran, James M.; Moriyama, Kotaro; Moscibrodzka, Monika; Müller, Cornelia; Musoke, Gibwa; Mejías, Alejandro Mus; Nagai, Hiroshi; Nagar, Neil M.; Nakamura, Masanori; Narayan, Ramesh; Narayanan, Gopal; Natarajan, Iniyan; Nathanail, Antonios; Neri, Roberto; Ni, Chunchong; Noutsos, Aristeidis; Okino, Hiroki; Olivares, Héctor; Ortiz-León, Gisela N.; Oyama, Tomoaki; Özel, Feryal; Palumbo, Daniel C. M.; Patel, Nimesh; Pen, Ue-Li; Pesce, Dominic W.; Piétu, Vincent; Plambeck, Richard; Popstefanija, Aleksandar; Porth, Oliver; Pötzl, Felix M.; Prather, Ben; Preciado-López, Jorge A.; Psaltis, Dimitrios; Pu, Hung-Yi; Rao, Ramprasad; Rawlings, Mark G.; Raymond, Alexander W.; Rezzolla, Luciano; Ricarte, Angelo; Ripperda, Bart; Roelofs, Freek; Rogers, Alan; Ros, Eduardo; Rose, Mel; Roshanineshat, Arash; Rottmann, Helge; Roy, Alan L.; Ruszczyk, Chet; Rygl, Kazi L. J.; Sánchez, Salvador; Sánchez-Arguelles, David; Savolainen, Tuomas; Schloerb, F. Peter; Schuster, Karl-Friedrich; Shao, Lijing; Shen, Zhiqiang; Small, Des; Sohn, Bong Won; Soohoo, Jason; Sun, He; Tazaki, Fumie; Tetarenko, Alexandra J.; Tiede, Paul; Tilanus, Remo P. J.; Titus, Michael; Toma, Kenji; Torne, Pablo; Trent, Tyler; Traianou, Efthalia; Trippe, Sascha; van Bemmel, Ilse; van Langevelde, Huib Jan; van Rossum, Daniel R.; Wagner, Jan; Ward-Thompson, Derek; Wardle, John; Weintroub, Jonathan; Wex, Norbert; Wharton, Robert; Wielgus, Maciek; Wong, George N.; Wu, Qingwen; Yoon, Doosoo; Young, André; Young, Ken; Younsi, Ziri; Yuan, Feng; Yuan, Ye-Fei; Zensus, J. Anton; Zhao, Guang-Yao; Zhao, Shan-Shan; Fermi Large Area Telescope Collaboration; Principe, G.; Giroletti, M.; D'Ammando, F.; Orienti, M.; H. E. S. S. Collaboration; Abdalla, H.; Adam, R.; Aharonian, F.; Benkhali, F. Ait; Angüner, E. O.; Arcaro, C.; Armand, C.; Armstrong, T.; Ashkar, H.; Backes, M.; Baghmanyan, V.; Barbosa Martins, V.; Barnacka, A.; Barnard, M.; Becherini, Y.; Berge, D.; Bernlöhr, K.; Bi, B.; Böttcher, M.; Boisson, C.; Bolmont, J.; de Lavergne, M. De Bony; Breuhaus, M.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Bylund, T.; Caroff, S.; Carosi, A.; Casanova, S.; Chand, T.; Chen, A.; Cotter, G.; Curyło, M.; Damascene Mbarubucyeye, J.; Davids, I. D.; Davies, J.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Ataï, A.; Dmytriiev, A.; Donath, A.; Doroshenko, V.; Duffy, C.; Dyks, J.; Egberts, K.; Eichhorn, F.; Einecke, S.; Emery, G.; Ernenwein, J. -P.; Feijen, K.; Fegan, S.; Fiasson, A.; de Clairfontaine, G. Fichet; Fontaine, G.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Giavitto, G.; Giunti, L.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M. -H.; Hahn, J.; Haupt, M.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Hörbe, M.; Horns, D.; Huber, D.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jardin-Blicq, A.; Joshi, V.; Jung-Richardt, I.; Kasai, E.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Khangulyan, D.; Khélifi, B.; Klepser, S.; Kluźniak, W.; Komin, Nu.; Konno, R.; Kosack, K.; Kostunin, D.; Kreter, M.; Lamanna, G.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J. -P.; Levy, C.; Lohse, T.; Lypova, I.; Mackey, J.; Majumdar, J.; Malyshev, D.; Malyshev, D.; Marandon, V.; Marchegiani, P.; Marcowith, A.; Mares, A.; Martí-Devesa, G.; Marx, R.; Maurin, G.; Meintjes, P. J.; Meyer, M.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Montanari, A.; Moore, C.; Morris, P.; Moulin, E.; Muller, J.; Murach, T.; Nakashima, K.; Nayerhoda, A.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Olivera-Nieto, L.; de Ona Wilhelmi, E.; Ostrowski, M.; Panter, M.; Panny, S.; Parsons, R. D.; Peron, G.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Noel, A. Priyana; Prokhorov, D. A.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Rauth, R.; Reichherzer, P.; Reimer, A.; Reimer, O.; Remy, Q.; Renaud, M.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Ruiz-Velasco, E.; Sahakian, V.; Sailer, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Scalici, M.; Schutte, H. M.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Senniappan, M.; Seyffert, A. S.; Shafi, N.; Shiningayamwe, K.; Simoni, R.; Sinha, A.; Sol, H.; Specovius, A.; Spencer, S.; Spir-Jacob, M.; Stawarz, Ł.; Sun, L.; Steenkamp, R.; Stegmann, C.; Steinmassl, S.; Steppa, C.; Takahashi, T.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tiziani, D.; Tluczykont, M.; Tomankova, L.; Trichard, C.; Tsirou, M.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Vincent, P.; Vink, J.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Watson, J.; Werner, F.; White, R.; Wierzcholska, A.; Wong, Yu Wun; Yusafzai, A.; Zacharias, M.; Zanin, R.; Zargaryan, D.; Zdziarski, A. A.; Zech, A.; Zhu, S. J.; Zorn, J.; Zouari, S.; Żywucka, N.; MAGIC Collaboration; Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Engels, A. Arbet; Artero, M.; Asano, K.; Baack, D.; Babić, A.; Baquero, A.; de Almeida, U. Barres; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bonnoli, G.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Ramazani, V. Fallah; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Moroni, P. G. Prada; Prandini, E.; Priyadarshi, C.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; VERITAS Collaboration; Adams, C. B.; Benbow, W.; Brill, A.; Capasso, M.; Christiansen, J. L.; Chromey, A. J.; Daniel, M. K.; Errando, M.; Farrell, K. A.; Feng, Q.; Finley, J. P.; Fortson, L.; Furniss, A.; Gent, A.; Giuri, C.; Hassan, T.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Jin, W.; Kaaret, P.; Kertzman, M.; Kieda, D.; Kumar, S.; Lang, M. J.; Lundy, M.; Maier, G.; Moriarty, P.; Mukherjee, R.; Nieto, D.; Nievas-Rosillo, M.; O'Brien, S.; Ong, R. A.; Otte, A. N.; Patel, S.; Pfrang, K.; Pohl, M.; Prado, R. R.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Ribeiro, D.; Richards, G. T.; Roache, E.; Rulten, C.; Ryan, J. L.; Santander, M.; Sembroski, G. H.; Shang, R.; Weinstein, A.; Williams, D. A.; Williamson, T. J.; Eavn Collaboration; Hirota, Tomoya; Cui, Lang; Niinuma, Kotaro; Ro, Hyunwook; Sakai, Nobuyuki; Sawada-Satoh, Satoko; Wajima, Kiyoaki; Wang, Na; Liu, Xiang; Yonekura, Yoshinori, In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded., The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovacion (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017- 82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RBC31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID 2019-107847RB-C41, PID2019-107847RB-C42, PID2019- 107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant No. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and CEX2019- 000920-S, and “Maria de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “Maria de Maeztu” MDM-2015-0509- 18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/ PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq, and FAPERJ. This research is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation and the Smithsonian Institution, by NSERC in Canada, and by the Helmholtz Association in Germany. This research used resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy’s Office of Science, and resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and at the collaborating institutions in the construction and operation of the instrument.
Published: 2021

31. In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent

Author: Graciela Pavon-Djavid, Virginie Gueguen, Caroline Roques, Liliane Louedec, Cécilia Delattre, Martine Jandrot-Perrus, Didier Letourneur, Anna Lokajczyk, Giuseppina Caligiuri, Catherine Boisson-Vidal, Véronique Ollivier, Thierry Avramoglou, Anne Meddahi-Pellé, Diego Velazquez, Univ Paris Diderot, INSERM, Lab Vasc Translat Sci U1148, Paris, France, Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)), Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL (ENSCP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European FP7 program PRESTIGE, Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Subjects: Medicine (General), Polyurethane, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Pharmaceutical Science, 02 engineering and technology, 030204 cardiovascular system & hematology, MESH: Polyurethanes, 0302 clinical medicine, Coating, Restenosis, MESH: Coated Materials, Biocompatible, MESH: Fibronectins, polycyclic compounds, Stent, Biology (General), Original Research, Neointimal hyperplasia, MESH: Immunoglobulin G, Chemistry, MESH: Peptides, MESH: Hydrophobic and Hydrophilic Interactions, Thin film surfaces, General Medicine, Adhesion, 021001 nanoscience & nanotechnology, 3. Good health, Endothelial stem cell, MESH: Immunoglobulin Fab Fragments, Biocompatibility, 0210 nano-technology, hormones, hormone substitutes, and hormone antagonists, endocrine system, MESH: Ions, Cobalt chrome, QH301-705.5, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, engineering.material, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, MESH: Chromium Alloys, R5-920, In vitro, In vivo, medicine, Animal model, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Dextran, Fibronectin, MESH: Surface Properties, MESH: Humans, medicine.disease, MESH: Cobalt, Immunoglobulin G, engineering, Haemocompatibility, Biomedical engineering
Abstract: International audience; Introduction: The major complications of stent implantation are restenosis and late stent thrombosis. PBMA polymers are used for stent coating because of their mechanical properties. We previously synthesized and characterized Dextrangraft-polybutylmethacrylate copolymer (Dex-PBMA) as a potential stent coating. In this study, we evaluated the haemocompatibility and biocompatibility properties of Dex-PBMA in vitro and in vivo. Methods: Here, we investigated: (1) the effectiveness of polymer coating under physiological conditions and its ability to release Tacrolimus®, (2) the capacity of Dex-PBMA to inhibit Staphylococcus aureus adhesion, (3) the thrombin generation and the human platelet adhesion in static and dynamic conditions, (4) the biocompatibility properties in vitro on human endothelial colony forming cells ( ECFC) and on mesenchymal stem cells (MSC) and in vivo in rat models, and (5) we implanted Dex-PBMA and Dex-PBMATAC coated stents in neointimal hyperplasia restenosis rabbit model. Results: Dex-PBMA coating efficiently prevented bacterial adhesion and release Tacrolimus®. Dex-PBMA exhibit haemocompatibility properties under flow and ECFC and MSC compatibility. In vivo, no pathological foreign body reaction was observed neither after intramuscular nor intravascular aortic implantation. After Dex-PBMA and Dex-PBMATAC coated stents 30 days implantation in a restenosis rabbit model, an endothelial cell coverage was observed and the lumen patency was preserved. Conclusion: Based on our findings, Dex-PBMA exhibited vascular compatibility and can potentially be used as a coating for metallic coronary stents.
Published: 2020

32. Very high energy γ-ray emission from two blazars of unknown redshift and upper limits on their distance

Author: Johan Bregeon, J. Devin, D. Gottschall, Zorawar Wadiasingh, Tadayuki Takahashi, R. J. White, Łukasz Stawarz, V. Barbosa Martins, H.M. Schutte, Maria Haupt, Thomas Lohse, Victor Doroshenko, Domenico Tiziani, M. Lemoine-Goumard, C. Arcaro, Michal Ostrowski, J.-P. Lenain, M. Panter, U. Katz, Michael Kreter, Jim Hinton, A. Lemiere, F. Eichhorn, M. de Naurois, R. Adam, Stefan Ohm, James Davies, Stefan Funk, Alicja Wierzcholska, Michael Punch, S. Sailer, Dmitry Khangulyan, D. A. Sanchez, H. Abdalla, M. Zacharias, M. A. Kastendieck, Stefano Gabici, T. Vuillaume, Rafal Moderski, R. J. Tuffs, N. Shafi, Natalia Żywucka, A. Fiasson, Samuel Timothy Spencer, M. Spir-Jacob, M. Seglar-Arroyo, Alexandre Marcowith, A. Santangelo, V. Baghmanyan, Nu. Komin, T. Chand, Jhilik Majumdar, J. Dyks, V. Joshi, P. deWilt, F. Ait Benkhali, L. Oakes, J. Bolmont, Mischa Breuhaus, Heike Prokoph, E. O. Angüner, G. Lamanna, Anton Dmytriiev, Davit Zargaryan, Ruizhi Yang, Q. Piel, Dmitriy Kostunin, Krzysztof Katarzynski, Catherine Boisson, Axel Donath, A. W. Chen, S. Caroff, V. Sahakian, F. Werner, G. Pühlhofer, Arnaud Mares, D. Jankowsky, R. Marx, M. Füßling, S. Schwemmer, Q. Remy, R. Rauth, Dieter Horns, G. Maurin, Y. A. Gallant, Marek Jamrozy, Clemens Hoischen, A. A. Zdziarski, A.S. Seyffert, R. Konno, M. Barnard, S. Nakashima, Anna Barnacka, Gavin Rowell, M. Mohamed, Riaan Steenkamp, M. Bryan, Helene Sol, A. Carosi, M. Hörbe, Sylvia Zhu, P. J. Meintjes, Michelle Tsirou, Christian Stegmann, Stefan Wagner, E. de Oña Wilhelmi, D. Malyshev, S. Raab, Yasunobu Uchiyama, J. Zorn, L. Rinchiuso, Isak Delberth Davids, Kirsty Feijen, Frank M. Rieger, Pierre Brun, R. D. Parsons, T. Tavernier, Jean-Pierre Ernenwein, I. Jung-Richardt, Jason John Watson, Roberta Zanin, L. Mohrmann, V. Poireau, Gianluca Giavitto, C. van Rensburg, S. Pita, Johannes Veh, K. Bernlöhr, H. Yoneda, Paolo Marchegiani, M. Tluczykont, D. J. van der Walt, A. Djannati-Ataï, Francois Brun, P. Vincent, Markus Holler, Misao Sasaki, Felix Jankowsky, Jacek Niemiec, V. Marandon, C. Trichard, H. Odaka, Felix Aharonian, Olaf Reimer, S. Bonnefoy, Constantin Steppa, Garret Cotter, Celine Armand, Michael Backes, E. Ruiz-Velasco, Thomas Bylund, D. Huber, M.-H. Grondin, Tim Holch, E. Leser, Thomas Murach, Joachim Hahn, J. Muller, G. Hermann, Regis Terrier, D. A. Prokhorov, K. Kosack, C. Levy, Ullrich Schwanke, Naomi Tsuji, Carlo Romoli, Angel Noel, Jonathan Mackey, D. Berge, Gerard Fontaine, B. Peyaud, Iryna Lypova, S. Chandra, L. Giunti, M. Katsuragawa, Yvonne Becherini, C. Moore, Dorit Glawion, K. Egberts, E. Moulin, A. Reimer, Tomasz Bulik, Halim Ashkar, Andreas Quirrenbach, M. Böttcher, Paul J. Morris, Kleopas Shiningayamwe, P. T. O'Brien, Lenka Tomankova, C. van Eldik, L. Dirson, J. F. Glicenstein, Tom Armstrong, Matteo Cerruti, H. Ndiyavala, B. van Soelen, B. Rudak, F. Schüssler, Werner Hofmann, M. Büchele, S. J. Fegan, F. Niederwanger, Bruno Khelifi, Jacco Vink, Sabrina Casanova, M. Curyło, Rachel Simoni, Masanori Arakawa, M. Scalici, G. Martí-Devesa, H. Iwasaki, G. Vasileiadis, Włodek Kluźniak, Christoph Deil, Mohanraj Senniappan, G. Emery, S. Saito, Armelle Jardin-Blicq, K. Nakashima, Heinrich J. Völk, M. Renaud, A. Sinha, Christo Venter, A. Zech, A.M. Taylor, Andreas Specovius, Stefan Klepser, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., German Research Foundation, Alexander von Humboldt Foundation, Centre National de la Recherche Scientifique (France), Japan Society for the Promotion of Science, Science and Technology Facilities Council (UK), Fundación 'la Caixa', National Aeronautics and Space Administration (US), H.E.S.S. Collaboration, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 33379009 - Kreter, Michael, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, and 34208968 - Zywucka-Hejzner, Natalia
Subjects: individual [BL Lacertae objects], Swift Gamma-Ray Burst Mission, VHE [gamma ray], satellite, Resolved and unresolved sources as a function of wavelength, Astrophysics, 01 natural sciences, GLAST, blazar, high-redshift [Galaxies], galaxies: high-redshift, 5/3, HESS, 0103 physical sciences, Atom, High Energy Stereoscopic System, Spectroscopy, Blazar, 010303 astronomy & astrophysics, BL Lacertae objects: individual, Astroparticle physics, Physics, general [Gamma-rays], energy: high, 010308 nuclear & particles physics, Astronomy and Astrophysics, gamma-rays: general, redshift, Redshift, gamma ray: VHE, 13. Climate action, Space and Planetary Science, ddc:520, high [energy], HESS - Abteilung Hinton, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract: H.E.S.S. Collaboration: et al., We report on the detection of very high energy (VHE; E > 100 GeV) γ-ray emission from the BL Lac objects KUV 00311−1938 and PKS 1440−389 with the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observations were accompanied or preceded by multiwavelength observations with Fermi/LAT, XRT and UVOT onboard the Swift satellite, and ATOM. Based on an extrapolation of the Fermi/LAT spectrum towards the VHE γ-ray regime, we deduce a 95 per cent confidence level upper limit on the unknown redshift of KUV 00311−1938 of z < 0.98 and of PKS 1440−389 of z < 0.53. When combined with previous spectroscopy results, the redshift of KUV 00311−1938 is constrained to 0.51 ≤ z < 0.98 and of PKS 1440−389 to 0.14 ⪅ z < 0.53., The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the Helmholtz Association, the Alexander von Humboldt Foundation, the French Ministry of Higher Education, Research and Innovation, the Centre National de la Recherche Scientifique (CNRS/IN2P3 and CNRS/INSU), the Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA), the U.K. Science and Technology Facilities Council (STFC), the Knut and Alice Wallenberg Foundation, the National Science Centre, Poland grant no. 2016/22/M/ST9/00382, the South African Department of Science and Technology and National Research Foundation, the University of Namibia, the National Commission on Research, Science and Technology of Namibia (NCRST), the Austrian Federal Ministry of Education, Science and Research and the Austrian Science Fund (FWF), the Australian Research Council (ARC), the Japan Society for the Promotion of Science, and the University of Amsterdam. We appreciate the excellent work of the technical support staff in Berlin, Zeuthen, Heidelberg, Palaiseau, Paris, Saclay, Tubingen, and in Namibia in the construction and operation of the equipment. This work benefited from services provided by the H.E.S.S. Virtual Organisation, supported by the national resource providers of the EGI Federation. The H.E.S.S. and Fermi/LAT analysis computations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) at Lunarc. Tomas Bylund and Yvonne Becherini wish to acknowledge the support of the Data Intensive Sciences and Applications (DISA) centre at Linnaeus University. Matteo Cerruti has received financial support through the Postdoctoral Junior Leader Fellowship Programme from “la Caixa” Foundation (LCF/BQ/PI18/11630012). This research made use of the NASA/IPAC Extragalactic Database (NED) and of the SIMBAD Astronomical Database, of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory/California Institute of Technology, funded by the National Aeronautics and Space Administration. We acknowledge the use of public data from the Swift data archive. This research made use of Gammapy, a community- developed core Python package for gamma-ray astronomy (Deil et al. 2017). This research has made use of data and software provided by the Fermi Science Support Center, managed by the HEASARC at the Goddard Space Flight Center. Part of this work is based on archival data, software or online services provided by the Space Science Data Center - ASI. This research has made use of the VizieR catalogue access tool, CDS, Strasbourg, France (doi:10.26093/cds/vizier). The original description of the VizieR service was published in A&AS 143, 23. This research has made use of the NASA/IPAC Infrared Science Archive, which is funded by the National Aeronautics and Space Administration and operated by the California Institute of Technology.
Published: 2020

33. Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation

Author: Virginie Mignon, Perrine Marquet de Rouge, Alison Domingues, Daniel Henrion, Catherine Boisson-Vidal, Virginie Escriou, Emilie Vessieres, Jérémy Sadoine, Pascal Bigey, Blandine Dizier, David M. Smadja, Valérie Nivet-Antoine, Catherine Chaussain, Innovations thérapeutiques en hémostase (IThEM - U1140), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pathologies, Imagerie et Biothérapies oro-faciales (EA 2496), Université Paris Descartes - Paris 5 (UPD5), Plateau technique Imagerie Cellulaire et Moléculaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Service d'Odontologie [Bretonneau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bretonneau, Service d'Hématologie et Laboratoire de Recherches Biochirugicales (Fondation Carpentier), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Boisson-Vidal, Catherine, MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, 0301 basic medicine, Cancer Research, Thioredoxin-Interacting Protein, Physiology, Angiogenesis, Clinical Biochemistry, Ischemia, Metabolic disorders, Neovascularization, Physiologic, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], medicine.disease_cause, Mice, 03 medical and health sciences, Thioredoxins, 0302 clinical medicine, Metabolic Diseases, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, In vivo, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Animals, Medicine, Endothelial dysfunction, Cells, Cultured, Mice, Knockout, business.industry, Metabolic disorder, Endothelial Cells, medicine.disease, Hindlimb, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Mice, Inbred C57BL, 030104 developmental biology, Cytoprotection, Oxidative stress, Post-ischemic revascularisation, 030220 oncology & carcinogenesis, Cancer research, Arterial damage, Carrier Proteins, business, TXNIP
Abstract: International audience; INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with siRNA or in a Cre-LoxP system could be involved in protection from high fat, high protein, low carbohydrate (HFHPLC) diet-induced oxidative stress and endothelial dysfunction, leading to vascular damage and impaired revascularisation in vivo.METHODS AND RESULTS:To investigate the role of endothelial TXNIP, the TXNIP gene was deleted in endothelial cells using anti-TXNIP siRNA treatment or the Cre-LoxP system. Murine models were fed a HFHPLC diet, known to induce metabolic disorders. Endothelial TXNIP targeting resulted in protection against metabolic disorder-related endothelial oxidative stress and endothelial dysfunction. This protective effect mitigates media cell loss induced by metabolic disorders and hampered metabolic disorder-related vascular dysfunction assessed by aortic reactivity and distensibility. In aortic ring cultures, metabolic disorders impaired vessel sprouting and this alteration was alleviated by deletion of endothelial TXNIP. When subjected to ischemia, mice fed a HFHPLC diet exhibited defective post-ischemic angiogenesis and impaired blood flow recovery in hind limb ischemia. However, reducing endothelial TXNIP rescued metabolic disorder-related impairment of ischemia-induced revascularisation.CONCLUSION:Collectively, these results show that targeting endothelial TXNIP in metabolic disorders is essential to maintaining endothelial function, vascular function and improving ischemia-induced revascularisation, making TXNIP a potential therapeutic target for therapy of vascular complications related to metabolic disorders.
Published: 2020

34. Prospects for γ-ray observations of narrow-line Seyfert 1 galaxies with the Cherenkov Telescope Array – II. γ–γ Absorption in the broad-line region radiation fields

Author: Luigi Foschini, Markus Böttcher, S. Vercellone, P. Romano, Catherine Boisson, Marco Landoni, 24420530 - Böttcher, Markus, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: galaxies [Gamma rays], Cherenkov Telescope Array, IACT, Astrophysics, model: absorption, 01 natural sciences, Spectral line, accretion, galaxies: individual: PKS 1502+036, propagation, individual: PMN J0948+0022 [Galaxies], black hole, 010303 astronomy & astrophysics, Line (formation), Physics, High Energy Astrophysical Phenomena (astro-ph.HE), galaxies: individual: SBS 0846+513, galaxies: individual: PMN J0948+0022, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, galaxies: Seyfert, gamma ray: emission, Eddington luminosity, symbols, Astrophysics - High Energy Astrophysical Phenomena, Seyfert [Galaxies], individual: PKS 1502+036 [Galaxies], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Cherenkov counter: atmosphere, VHE, GLAST, symbols.namesake, 0103 physical sciences, gamma rays: galaxies, quasar, Cherenkov radiation, Astrophysics::Galaxy Astrophysics, 010308 nuclear & particles physics, background, Astronomy and Astrophysics, Quasar, galaxies: jets, sensitivity, photon photon: absorption, Galaxy, Automatic Keywords, Space and Planetary Science, individual: SBS 0846+513 [Galaxies], jets [Galaxies], galaxy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Gamma-ray emitting narrow-line Seyfert 1 ($\gamma$-NLS1) galaxies possibly harbour relatively low-mass black holes (10$^6$-10$^8$ M$_{\odot}$) accreting close to the Eddington limit, and share many characteristics with their sibling sources, flat-spectrum radio quasars. Although they have been detected in the MeV--GeV band with Fermi-LAT, they have never been seen in the very high energy band with current imaging atmospheric Cherenkov telescopes (IACTs). Thus, they are key targets for the next-generation IACT, the Cherenkov Telescope Array (CTA). In a previous work we selected, by means of extensive simulations, the best candidates for a prospective CTA detection (SBS 0846$+$513, PMN J0948$+$0022, and PKS 1502$+$036) taking into account the effects of both the intrinsic absorption (approximated with a cut-off at 30 GeV), and the extra-galactic background light on the propagation of $\gamma$-rays. In this work we simulate the spectra of these three sources by adopting more realistic broad-line region (BLR) absorption models. In particular, we consider the detailed treatment of $\gamma$-$\gamma$ absorption in the radiation fields of the BLR as a function of the location of the $\gamma$-ray emission region with parameters inferred from observational constraints. We find that, due to the energy range extent and its sensitivity, CTA is particularly well suited to locate the $\gamma$-ray emitting region in $\gamma$-NLS1. In particular CTA will be able not only to distinguish whether the $\gamma$-ray emitting region is located inside or outside the BLR, but also where inside the BLR it may be., Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society. 15 pages, 8 figures, 7 tables
Published: 2020

35. Detection of very-high-energy γ -ray emission from the colliding wind binary η Car with H.E.S.S

Author: E. O. Angüner, Ramin Marx, M. Panter, U. Katz, G. Heinzelmann, Iryna Lypova, S. Nakashima, Yvonne Becherini, G. Martí-Devesa, Stefan Klepser, H. Yoneda, A. Fiasson, L. Giunti, P. deWilt, J. King, R. Adam, I. Jung-Richardt, James Davies, F. Eichhorn, Michael Punch, Maria Haupt, R. J. Tuffs, Michal Ostrowski, J.-P. Lenain, Stefan Ohm, Łukasz Stawarz, J. F. Glicenstein, Frank M. Rieger, Markus Holler, Michelle Tsirou, C. Levy, S. Pita, S. Colafrancesco, L. Rinchiuso, Q. Remy, Felix Jankowsky, J. Zorn, M.-H. Grondin, Mischa Breuhaus, C. Arcaro, Stefano Gabici, F. Niederwanger, Jacco Vink, Sabrina Casanova, Halim Ashkar, M. Curyło, Stefan Funk, Alicja Wierzcholska, Gavin Rowell, M. Bryan, Felix Aharonian, N. Shafi, R. D. Parsons, H. Ndiyavala, B. van Soelen, B. Rudak, Dmitriy Kostunin, K. Nakashima, Nu. Komin, Natalia Żywucka, M. de Naurois, T. Chand, Jhilik Majumdar, L. Oakes, A. Lemière, Heinrich J. Völk, M. Renaud, R. Rauth, Axel Donath, A. W. Chen, M. Büchele, S. Eschbach, M. Barnard, Marek Jamrozy, J. Bolmont, Gianluca Giavitto, K. Bernlöhr, Helene Sol, V. Poireau, H. Odaka, M. Füßling, Jacek Niemiec, Rafal Moderski, C. Perennes, K. Egberts, Dieter Horns, Olaf Reimer, M. Lemoine-Goumard, J. Dyks, Ruizhi Yang, Francois Brun, Reinhard Schlickeiser, Zorawar Wadiasingh, M. Böttcher, Michael Kreter, S. Chandra, Paolo Marchegiani, P. Vincent, S. J. Fegan, A. Djannati-Ataï, V. Barbosa Martins, S. Raab, L. Dirson, F. Gaté, Kirsty Feijen, S. Bonnefoy, Constantin Steppa, Alexandre Marcowith, M. Zacharias, Rachel Simoni, Masanori Arakawa, Celine Armand, Thomas Murach, Joachim Hahn, T. Vuillaume, A. Schulz, Clemens Hoischen, A. A. Zdziarski, Ullrich Schwanke, V. Joshi, V. Sahakian, A. Carosi, F. Werner, F. Ait Benkhali, E. de Oña Wilhelmi, Anton Dmytriiev, Isak Delberth Davids, S. Schwemmer, Arnaud Mares, Andrea Santangelo, Jim Hinton, Roberta Zanin, C. Trichard, S. Sailer, Dmitry Khangulyan, P. J. Meintjes, Tom Armstrong, Matteo Cerruti, D. A. Sanchez, M. Seglar-Arroyo, P.-O. Petrucci, Johan Bregeon, R. J. White, J. Devin, F. Schüssler, M. Scalici, A. Priyana Noel, Domenico Tiziani, D. Malyshev, Tadayuki Takahashi, A.M. Taylor, Werner Hofmann, Michael Backes, Jonathan Mackey, Victor Doroshenko, Gilles Henri, Heike Prokoph, C. Moore, Q. Piel, Dorit Glawion, Tim Holch, E. Moulin, Tomasz Bulik, S. Caroff, D. Huber, Marion Spir-Jacob, G. Maurin, H. Iwasaki, A.S. Seyffert, Naomi Tsuji, D. Jankowsky, Gerard Fontaine, M. Katsuragawa, Andreas Quirrenbach, Hester Schutte, Riaan Steenkamp, Andreas Specovius, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, L. Mohrmann, C. van Rensburg, Misao Sasaki, D. J. van der Walt, M. Hörbe, T. Tavernier, E. Leser, P. T. O'Brien, B. Khélifi, G. Hermann, Regis Terrier, Carlo Romoli, Christo Venter, Y. A. Gallant, Atreyee Sinha, C. van Eldik, A. Zech, M. Mohamed, Garret Cotter, D. A. Prokhorov, K. Kosack, B. Peyaud, G. Pühlhofer, A. Reimer, Pierre Brun, Jean-Pierre Ernenwein, Johannes Veh, R. Blackwell, E. Ruiz-Velasco, G. Emery, S. Saito, Thomas Bylund, M. Tluczykont, Armelle Jardin-Blicq, Jacques Muller, Samuel Timothy Spencer, H. Abdalla, M. A. Kastendieck, G. Vasileiadis, Włodek Kluźniak, Krzysztof Katarzynski, Catherine Boisson, Christoph Deil, Mohanraj Senniappan, D. Berge, Paul J. Morris, Kleopas Shiningayamwe, Lenka Tomankova, Jason John Watson, V. Marandon, D. Gottschall, Thomas Lohse, G. Lamanna, Alexander von Humboldt Foundation, Southern California Earthquake Center, EGI Foundation, Science and Technology Facilities Council (UK), Australian Research Council, German Research Foundation, Japan Society for the Promotion of Science, University of Amsterdam, Federal Ministry of Education and Research (Germany), Austrian Science Fund, Knut and Alice Wallenberg Foundation, Max Planck Society, National Science Centre (Poland), Centre National de la Recherche Scientifique (France), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), Helmholtz Association, National Commission on Research Science and Technology (Namibia), University of Namibia, Federal Ministry of Education, Science and Research (Austria), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), H.E.S.S., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S. Collaboration, Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: individual: η CarStars: Wolf-Rayet [Stars], Photon, stars: individual: η Car, Astrophysics::High Energy Astrophysical Phenomena, Flux, Cosmic ray, Astrophysics, 01 natural sciences, cosmic rays, 0103 physical sciences, individual: η Car [stars], High Energy Stereoscopic System, 010303 astronomy & astrophysics, Cosmic rays, Colliding-wind binary, Astroparticle physics, Physics, Spectral index, non-thermal [Radiation mechanisms], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], general [Binaries], 010308 nuclear & particles physics, Astronomy and Astrophysics, radiation mechanisms: non-thermal, Wolf-Rayet [stars], binaries: general, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], astroparticle physics, ddc:520, HESS - Abteilung Hinton, stars: Wolf-Rayet, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Stars: individual: η CarStars: Wolf-Rayet, Noise (radio)
Abstract: Aims. Colliding wind binary systems have long been suspected to be high-energy (HE; 100 MeV < E < 100 GeV) {\gamma}-ray emitters. {\eta} Car is the most prominent member of this object class and is confirmed to emit phase-locked HE {\gamma} rays from hundreds of MeV to ~100 GeV energies. This work aims to search for and characterise the very-high-energy (VHE; E >100 GeV) {\gamma}-ray emission from {\eta} Car around the last periastron passage in 2014 with the ground-based High Energy Stereoscopic System (H.E.S.S.). Methods. The region around {\eta} Car was observed with H.E.S.S. between orbital phase p = 0.78 - 1.10, with a closer sampling at p {\approx} 0.95 and p {\approx} 1.10 (assuming a period of 2023 days). Optimised hardware settings as well as adjustments to the data reduction, reconstruction, and signal selection were needed to suppress and take into account the strong, extended, and inhomogeneous night sky background (NSB) in the {\eta} Car field of view. Tailored run-wise Monte-Carlo simulations (RWS) were required to accurately treat the additional noise from NSB photons in the instrument response functions. Results. H.E.S.S. detected VHE {\gamma}-ray emission from the direction of {\eta} Car shortly before and after the minimum in the X-ray light-curve close to periastron. Using the point spread function provided by RWS, the reconstructed signal is point-like and the spectrum is best described by a power law. The overall flux and spectral index in VHE {\gamma} rays agree within statistical and systematic errors before and after periastron. The {\gamma}-ray spectrum extends up to at least ~400 GeV. This implies a maximum magnetic field in a leptonic scenario in the emission region of 0.5 Gauss. No indication for phase-locked flux variations is detected in the H.E.S.S. data., Comment: 9 pages, 4 figures, 3 tables, in press with A&A
Published: 2020

36. Resolving the Crab pulsar wind nebula at teraelectronvolt energies

Author: Natalia Żywucka, M. de Naurois, T. Chand, Frank M. Rieger, J. Bolmont, S. Colafrancesco, Ruizhi Yang, W. Kluźniak, S. Eschbach, Jim Hinton, R. Simoni, Dmitry Khangulyan, Christopher J. Moore, G. Fontaine, M. Büchele, D. A. Sanchez, T. Tavernier, L. Mohrmann, Denys Malyshev, J. Veh, S. Klepser, B. Khélifi, H. M. Schutte, C. Perennes, D. Glawion, Christoph Deil, Mohanraj Senniappan, A.A. Zdziarski, A. Djannati-Ataï, Y.A. Gallant, Gavin Rowell, Stefan Funk, T. Takahashi, Gianluca Giavitto, Axel Donath, A. W. Chen, M. Bryan, J. Dyks, D. Zaborov, I. Oya, G. Heinzelmann, K. Shiningayamwe, T. Lohse, Yvonne Becherini, M. Renaud, H. Iwasaki, M. Holler, J.-P. Ernenwein, P. Vincent, R. D. Parsons, G. Emery, H. Odaka, Christo Venter, D. Huber, M. Arakawa, D. Berge, M. Capasso, Matteo Cerruti, Nachiketa Chakraborty, F. Niederwanger, A. Marcowith, A. Zech, E. Leser, Jacco Vink, R. Rauth, Sabrina Casanova, C. Arcaro, I. Jung-Richardt, T. Vuillaume, G. Hermann, D. Gottschall, Werner Hofmann, Regis Terrier, J. Becker Tjus, A. Schulz, Carlo Romoli, M. Panter, M. Seglar-Arroyo, H. Ndiyavala, B. van Soelen, Felix Aharonian, M. Haupt, Lukasz Stawarz, Michael Punch, V. Doroshenko, M. Spir-Jacob, R. Tuffs, R. C. G. Chaves, E. O. Angüner, A. Priyana Noel, L. O'c. Drury, S. Saito, J.F. Glicenstein, D. J. van der Walt, S. Raab, Andreas Quirrenbach, C. Steppa, J.-P. Lenain, N. Shafi, K. Egberts, Robert Wagner, K. Kosack, J. Hahn, Reinhard Schlickeiser, M. Tsirou, G. Vasileiadis, M. Kraus, S. Chandra, S. Nakashima, G. Martí-Devesa, M. Katsuragawa, Ruben Lopez-Coto, M.-H. Grondin, M. Böttcher, R. Blackwell, E. Ruiz-Velasco, L. Dirson, Stefan Ohm, Léa Jouvin, S. Pita, F. Schüssler, P. deWilt, J. King, F. Voisin, Julien Lefaucheur, A. Dmytriiev, R. Moderski, S. Gabici, A. Fiasson, J. Lau, L. Oakes, I.D. Davids, Alison Mitchell, L. Rinchiuso, P.J. Meintjes, Heike Prokoph, Zorawar Wadiasingh, R. J. White, S. Fegan, Dieter Horns, V. Poireau, Monica Barnard, P.-O. Petrucci, H. Abdalla, D. Jankowsky, Q. Piel, C. Stegmann, Nu. Komin, Marek Jamrozy, Catherine Boisson, Helene Sol, Pierre Brun, A.S. Seyffert, A. Carosi, M. Füßling, M.A. Kastendieck, S. Bonnefoy, N. Tsuji, F. Gaté, J. Devin, G. Henri, D. A. Prokhorov, D. Tiziani, C. Hoischen, Ullrich Schwanke, A. Specovius, R. Steenkamp, A. Reimer, J. Bregeon, Francois Brun, B. Condon, Michael Backes, H. Yoneda, Tim Holch, M. Tluczykont, E. Moulin, Tomasz Bulik, T. Bylund, A. Jacholkowska, S. Caroff, Celine Armand, F. Jankowsky, Stefan Wagner, Yasunobu Uchiyama, C. van Rensburg, M. Zacharias, C. Trichard, F. Ait Benkhali, Manami Sasaki, S. Schwemmer, Andrea Santangelo, A. Ziegler, G. Maurin, A. Wierzcholska, C. Mariaud, Jacek Niemiec, Olaf Reimer, Thomas Murach, A. Lemière, M. Lemoine-Goumard, I. Shilon, Heinrich J. Völk, R. Marx, P. Bordas, I. Lypova, G. Lamanna, J. Zorn, U. Katz, J.-P. Tavernet, B. Rudak, V. Marandon, K. Katarzyński, A.M. Taylor, V. Sahakian, M. Mohamed, M. Ostrowski, Konrad Bernlöhr, B. Peyaud, G. Pühlhofer, R. Zanin, P. T. O'Brien, Atreyee Sinha, C. van Eldik, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, H.E.S.S., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), European Commission, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Armagh Observatory, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), Gravitation and Astroparticle Physics Amsterdam, 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 30366755 - Chand, Tej B., 31125417 - Chandra, Sunil, 26403366 - Ndiyavala, Hambeleleni, 10060499 - Van der Walt, Diederick Johannes, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 29092086 - Zacharias, Michael, and Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010504 meteorology & atmospheric sciences, Electromagnetic spectrum, electron: relativistic, magnetic field, Astrophysics, positron: energy, 01 natural sciences, 7. Clean energy, Pulsar wind nebula, particle: acceleration, Raigs gamma, Astrophysics::Solar and Stellar Astrophysics, HESS - Abteilung Hofmann, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, pulsar, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, [PHYS]Physics [physics], Nebula, radio wave, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 4. Education, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], photon, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, High-energy astrophysics, Particle astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Camps magnètics, accelerator, High-energy astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, gap, X-ray, energy loss: rotation, Pulsar, 0103 physical sciences, synchrotron, Astrophysics::Galaxy Astrophysics, gamma ray: energy, 0105 earth and related environmental sciences, Crab Pulsar, Gamma rays, Astronomy and Astrophysics, Crab Nebula, electromagnetic, gamma ray: VHE, [SDU]Sciences of the Universe [physics], Magnetic fields, ddc:520, Physics::Accelerator Physics
Abstract: arXiv:1909.09494v2, H.E.S.S. Collaboration: et al., The support of the Namibian authorities and of the University of Namibia in facilitating the construction and operation of H.E.S.S. is gratefully acknowledged, as is the support by the German Ministry for Education and Research (BMBF), the Max Planck Society, the German Research Foundation (DFG), the Helmholtz Association, the Alexander von Humboldt Foundation, the French Ministry of Higher Education, Research and Innovation, the Centre National de la Recherche Scientifique (CNRS/IN2P3 and CNRS/INSU), the Commissariat à l’énergie atomique et aux énergies alternatives (CEA), the UK Science and Technology Facilities Council (STFC), the Knut and Alice Wallenberg Foundation, the National Science Centre, Poland (grant number 2016/22/M/ST9/00382), the South African Department of Science and Technology and the National Research Foundation, the University of Namibia, the National Commission on Research, Science and Technology of Namibia (NCRST), the Austrian Federal Ministry of Education, Science and Research and the Austrian Science Fund (FWF), the Australian Research Council (ARC), the Japan Society for the Promotion of Science and the University of Amsterdam. We appreciate the excellent work of the technical support staff in Berlin, Zeuthen, Heidelberg, Palaiseau, Paris, Saclay, Tübingen and Namibia in the construction and operation of the equipment. This work benefited from services provided by the H.E.S.S. Virtual Organisation, supported by the national resource providers of the EGI Federation. R.C.G.C. was funded by EU FP7 Marie Curie (grant agreement number PIEF-GA-2012-332350).
Published: 2020

37. Optical spectroscopy of Blazars for the Cherenkov Telescope Array

Author: S. Pita, Elina Lindfors, Catherine Boisson, P. Goldoni, O. Hervet, H. Sol, J. Becerra-Gonzalez, Garret Cotter, V. Navarro-Aranguiz, Walter Max-Moerbeck, Stephan Wagner, E. Kasai, Michael Backes, J.-P. Lenain, David A. Williams, Filippo D'Ammando, U. Barres de Almeida, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Santa Cruz Institute for Particle Physics (SCIPP), University of California [Santa Cruz] (UCSC), University of California-University of California, Universitad de Chile, Centro Brasileiro de Pesquisas Físicas (CBPF), Ministério da Ciência e Tecnologia, Universidad de La Laguna [Tenerife - SP] (ULL), Instituto de Astrofisica de Canarias (IAC), University of Oxford [Oxford], Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Finnish Centre for Astronomy with ESO (FINCA), University of Turku, Landessternwarte Königstuhl [ZAH] (LSW), Universität Heidelberg [Heidelberg], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of California [Santa Cruz] (UC Santa Cruz), University of California (UC)-University of California (UC), University of Oxford, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Universität Heidelberg [Heidelberg] = Heidelberg University
Subjects: [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], gamma-rays: galaxies, Astrophysics::High Energy Astrophysical Phenomena, Population, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, Telescope, law, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, education, Blazar, 010303 astronomy & astrophysics, Spectrograph, Astrophysics::Galaxy Astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), education.field_of_study, 010308 nuclear & particles physics, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, gamma-rays galaxies, BL Lacertae objects: general, Cherenkov Telescope Array, Astrophysics - Astrophysics of Galaxies, Galaxy, Redshift, [PHYS.ASTR.GA]Physics [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Extragalactic background light, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), galaxies: distances and redshifts, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Context. Blazars are the most numerous class of High Energy (HE; E about 50 MeV - few 100 GeV) and Very High Energy (VHE; E about 100 GeV - 10 TeV) gamma-ray emitters. As of today, a measured spectroscopic redshift is available for only about 50% of gamma-ray BL Lacs, mainly due to the difficulty of measuring reliable redshifts from their nearly featureless, continuum-dominated optical spectra. The knowledge of the redshift is fundamental for understanding the emission from blazars, for population studies and also for indirect studies of the extragalactic background light and searches for Lorentz invariance violation and axion-like particles using blazars. Aims. This paper is the first of a series of papers which aim to measure the redshift of a sample of blazars likely to be detected with the upcoming Cherenkov Telescope Array (CTA), a ground based gamma-ray observatory. Methods. Monte Carlo simulations were performed to select those hard spectrum gamma-ray blazars detected with the Fermi-LAT telescope still lacking redshift measurements but likely to be detected by CTA in 30 hours of observing time or less. Optical observing campaigns involving deep imaging and spectroscopic observations were organised to efficiently constrain their redshifts. We performed deep medium to high resolution spectroscopy of nineteen blazar optical counterparts using the ESI spectrograph at Keck, the RSS spectrograph at the SALT telescope, and the EFOSC2 spectrograph at the ESO NTT. We searched systematically for spectral features and, when possible, we estimated the contribution of the host galaxy to the total flux. Results. We measured eleven firm spectroscopic redshifts with values ranging from 0.1116 to 0.482. one tentative redshift, three redshift lower limits including one at z > 0.449 and another at z > 0.868. There were four objects found to have featureless spectra., Accepted by Astronomy & Astrophysics
Published: 2020
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38. Ceramide 1-Phosphate Protects Endothelial Colony–Forming Cells From Apoptosis and Increases Vasculogenesis In Vitro and In Vivo

Author: Virginie Mignon, Soledad Negrotto, Blandine Dizier, Mirta Schattner, Hebe Agustina Mena, Paula Romina Zubiry, Fernanda Parborell, Catherine Boisson-Vidal, Laboratory of Experimental Thrombosis [Buenos Aires, Argentina] (IMEX), National Academy of Medicine-Institute of Experimental Medicine (IMEX), Thrombose : Épidémiologie, Physiopathologie et Thérapeutiques Innovantes (UMR_S 765), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Optimisation Thérapeutique en Neuropsychopharmacologie (VariaPsy - U1144), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Innovations thérapeutiques en hémostase (IThEM - U1140), Variabilité de réponse aux Psychotropes (VariaPsy - U1144), and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)
Subjects: 0301 basic medicine, Ceramide, CIENCIAS MÉDICAS Y DE LA SALUD, Angiogenesis, CERMIDE 1 PHOSPHATE, Neovascularization, Physiologic, purl.org/becyt/ford/3.5 [https], Apoptosis, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 030204 cardiovascular system & hematology, Ceramides, Sensitivity and Specificity, Mice, 03 medical and health sciences, chemistry.chemical_compound, PROANGIOGENIC, 0302 clinical medicine, Vasculogenesis, Cell Movement, In vivo, Ischemia, Morphogenesis, Animals, Humans, Regeneration, Progenitor cell, Cells, Cultured, Cell Proliferation, endothelial progenitor cells, Regeneration (biology), Cell Differentiation, Sphingolipid, Otras Ciencias Médicas, 3. Good health, Cell biology, Disease Models, Animal, 030104 developmental biology, chemistry, VASCULOGENESIS, purl.org/becyt/ford/3 [https], ENDOTHELIAL COLONY FORMING CELLS, Cell transplantation, Cardiology and Cardiovascular Medicine
Abstract: Objective: Ceramide 1-phosphate (C1P) is a bioactive sphingolipid highly augmented in damaged tissues. Because of its abilities to stimulate migration of murine bone marrow–derived progenitor cells, it has been suggested that C1P might be involved in tissue regeneration. In the present study, we aimed to investigate whether C1P regulates survival and angiogenic activity of human progenitor cells with great therapeutic potential in regenerative medicine such as endothelial colony–orming cells (ECFCs). Approach and Results: C1P protected ECFC from TNFα (tumor necrosis factor-α)-induced and monosodium urate crystal–induced death and acted as a potent chemoattractant factor through the activation of ERK1/2 (extracellular signal-regulated kinases 1 and 2) and AKT pathways. C1P treatment enhanced ECFC adhesion to collagen type I, an effect that was prevented by β1 integrin blockade, and to mature endothelial cells, which was mediated by the E-selectin/CD44 axis. ECFC proliferation and cord-like structure formation were also increased by C1P, as well as vascularization of gel plug implants loaded or not with ECFC. In a murine model of hindlimb ischemia, local administration of C1P alone promoted blood perfusion and reduced necrosis in the ischemic muscle. Additionally, the beneficial effects of ECFC infusion after ischemia were amplified by C1P pretreatment, resulting in a further and significant enhancement of leg reperfusion and muscle repair. Conclusions: Our findings suggest that C1P may have therapeutic relevance in ischemic disorders, improving tissue repair by itself, or priming ECFC angiogenic responses such as chemotaxis, adhesion, proliferation, and tubule formation, which result in a better outcome of ECFC-based therapy. Fil: Mena, Hebe Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Zubiry, Paula Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Dizier, Blandine. Universite de Paris; Francia. Inserm; Francia Fil: Mignon, Virginie. Inserm; Francia. Universite de Paris; Francia Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Boisson Vidal, Catherine. Inserm; Francia. Universite de Paris; Francia Fil: Negrotto, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Published: 2019

39. H.E.S.S. and Suzaku observations of the Vela X pulsar wind nebula

Author: P. deWilt, J. King, C. Mariaud, J. Zorn, J. Dyks, Matteo Cerruti, Nachiketa Chakraborty, Jacek Niemiec, D. J. van der Walt, Florian Gaté, R. C. G. Chaves, E. O. Angüner, G. Lamanna, S. Nakashima, Olaf Reimer, H. Yoneda, Werner Hofmann, J. Lau, Michelle Tsirou, N. Shafi, Natalia Żywucka, M. de Naurois, Michael Punch, L. Rinchiuso, Michael Backes, Sami Caroff, Thomas Murach, D. A. Prokhorov, K. Kosack, Konrad Bernlöhr, M.-H. Grondin, G. Emery, Stefan Ohm, S. Saito, Axel Donath, A. W. Chen, F. Niederwanger, Markus Böttcher, M. Seglar-Arroyo, S. Pita, G. Pühlhofer, Krzysztof Katarzynski, Tim Holch, Ramin Marx, M. Panter, U. Katz, Jacco Vink, Catherine Boisson, A. Reimer, Marek Jamrozy, Ruizhi Yang, Stefano Gabici, Naomi Tsuji, Emmanuel Moulin, Pierre Brun, V. Marandon, I. Oya, M. Kraus, Helene Sol, I. Shilon, Sabrina Casanova, M. Büchele, F. Ait Benkhali, Anton Dmytriiev, Jean-Pierre Ernenwein, A. Fiasson, Manami Sasaki, L. Oakes, C. Perennes, S. Schwemmer, Andrea Santangelo, J. Bolmont, S. J. Fegan, A. Djannati-Ataï, R. D. Parsons, V. Poireau, Dieter Horns, D. Jankowsky, Johannes Veh, M. Tluczykont, F. Schüssler, A. Schulz, S. Bonnefoy, H. Abdalla, M. A. Kastendieck, T. Chand, G. Vasileiadis, Constantin Steppa, E. de Oña Wilhelmi, Isak Delberth Davids, M. Mohamed, E. Leser, Włodek Kluźniak, Roberta Zanin, Y. A. Gallant, Clemens Hoischen, A. A. Zdziarski, Nu. Komin, Iryna Lypova, Gianluca Giavitto, Heinrich J. Völk, Yvonne Becherini, P. T. O'Brien, Ullrich Schwanke, M. Renaud, B. van Soelen, B. Condon, Riaan Steenkamp, B. Khélifi, G. Hermann, Regis Terrier, Rachel Simoni, Carlo Romoli, Christoph Deil, B. Rudak, D. Gottschall, Anne Lemiere, Justine Devin, Mohanraj Senniappan, A. Carosi, K. Egberts, Masanori Arakawa, Pascal Vincent, H. Odaka, Frank M. Rieger, R. Blackwell, E. Ruiz-Velasco, Thomas Bylund, S. Raab, I. Jung-Richardt, Tadayuki Takahashi, A. S. Seyffert, Atreyee Sinha, Kirsty Feijen, C. van Eldik, Victor Doroshenko, Markus Holler, G. Heinzelmann, Felix Jankowsky, D. Berge, M. Füßling, N. Maxted, R. J. Tuffs, Felix Aharonian, G. Martí-Devesa, H. Prokoph, Jim Hinton, Dmitry Khangulyan, Alison Mitchell, S. Eschbach, Thomas Lohse, H. Iwasaki, L. Tibaldo, J.-P. Tavernet, Kleopas Shiningayamwe, F. Voisin, Reinhard Schlickeiser, S. Colafrancesco, S. Chandra, M. Capasso, Michal Ostrowski, V. Sahakian, J.-P. Lenain, Dmitriy Kostunin, L. Dirson, R. J. White, R. Rauth, Gilles Maurin, Zorawar Wadiasingh, Stefan Funk, Alicja Wierzcholska, Domenico Tiziani, D. Malyshev, Monica Barnard, Thomas Tavernier, B. Peyaud, Maria Haupt, Hester Schutte, L. O'c. Drury, A.M. Taylor, Rafal Moderski, Andreas Specovius, Christo Venter, C. Trichard, P. J. Meintjes, A. Zech, David Sánchez, A. Ziegler, Léa Jouvin, Marion Spir-Jacob, D. Huber, C. Arcaro, Gavin Rowell, M. Bryan, D. Zaborov, C. Moore, Dorit Glawion, Tomasz Bulik, M. Katsuragawa, A. Jacholkowska, Andreas Quirrenbach, Michael Zacharias, Joachim Hahn, P.-O. Petrucci, Stefan Klepser, Łukasz Stawarz, Gilles Henri, Q. Piel, Christian Stegmann, Stefan Wagner, Yasunobu Uchiyama, L. Mohrmann, C. van Rensburg, T. Vuillaume, J. F. Glicenstein, A. Priyana Noel, Francois Brun, J. Bregeon, Celine Armand, Ruben Lopez-Coto, M. Lemoine-Goumard, Gilles Fontaine, A. Marcowith, Hambeleleni Ndiyavala, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), H.E.S.S. Collaboration, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), API Other Research (FNWI), Faculty of Science, High Energy Astrophys. & Astropart. Phys (API, FNWI), 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, M., 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 31125417 - Chandra, Sunil, 26403366 - Ndiyavala, Hambeleleni, 22799133 - Schutte, Hester M., 20126999 - Seyffert, Albertus Stefanus, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, 30366755 - Chand, T.B., 34208968 - Zywucka-Hejzner, Natalia, 10060499 - Van der Walt, Diederick Johannes, 28644743 - Backes, Michael, 30366755 - Chand, Tej B., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Camps magnètics, Astrophysics::High Energy Astrophysical Phenomena, Synchrotron radiation, FOS: Physical sciences, Cosmic ray, Astrophysics, Vela, gamma rays: stars, 01 natural sciences, 7. Clean energy, Pulsar wind nebula, outflows, Relativistic particle, Raigs gamma, Pulsar, 0103 physical sciences, ddc:530, winds, outflows [stars], 010303 astronomy & astrophysics, individual: PSR B0833-45 [pulsars], Astrophysics::Galaxy Astrophysics, acceleration of particles, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, Computer Science::Information Retrieval, Gamma rays, Institut für Physik und Astronomie, Astronomy and Astrophysics, radiation mechanisms: non-thermal, non-thermal [radiation mechanisms], stars [gamma rays], pulsars: individual: PSR B0833-45, Crab Nebula, 13. Climate action, Space and Planetary Science, stars: winds, Magnetic fields, ddc:520, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Heliosphere
Abstract: Pulsar Wind Nebulae (PWNe) represent the most prominent population of Galactic very-high-energy gamma-ray sources and are thought to be an efficient source of leptonic cosmic rays. Vela X is a nearby middle-aged PWN, which shows bright X-ray and TeV gamma-ray emission toward an elongated structure called the cocoon. Since TeV emission is likely inverse-Compton emission of electrons while X-ray emission is synchrotron radiation of the same electrons, we aim to derive the properties of the relativistic particles and of magnetic fields with minimal modelling. We use data from the Suzaku XIS to derive the spectra from three compact regions in Vela X covering distances from 0.3 pc to 4 pc from the pulsar along the cocoon. We obtain gamma-ray spectra of the same regions from H.E.S.S. observations and fit a radiative model to the multi-wavelength spectra. The TeV electron spectra and magnetic field strengths are consistent within the uncertainties for the three regions, with energy densities of the order $10^{-12}\rm\,erg\,cm^{-3}$. The data indicate the presence of a cutoff in the electron spectrum at energies of $\sim$100 TeV and a magnetic field strength of $\sim$$6\,\rm\mu G$. Constraints on the presence of turbulent magnetic fields are weak. The pressure of TeV electrons and magnetic fields in the cocoon is dynamically negligible, requiring the presence of another dominant pressure component. Sub-TeV electrons cannot account completely for the missing pressure, that may be provided either by relativistic ions or from mixing of the ejecta with the pulsar wind. The electron spectra are consistent with expectations from transport scenarios dominated either by advection via the reverse shock or by diffusion. Constraints on turbulent magnetic fields and the shape of the electron cutoff can be improved by spectral measurements in the energy range $\gtrsim 10\rm\,keV$. (abridged), Comment: Accepted for publication in A&A
Published: 2019

40. Towards open and reproducible multi-instrument analysis in gamma-ray astronomy

Author: Kai Brügge, N. Kelley-Hoskins, R. Zanin, M. Nöthe, José Enrique Ruiz, Jelena Aleksić, Catherine Boisson, Karl Kosack, B. Khélifi, Tarek M. Hassan, Axel Donath, J. Rico, J. King, Jose Luis Contreras, T. T.Y. Lin, L. Jouvin, Ralph Bird, Christoph Deil, Regis Terrier, Lab Saha, Atreyee Sinha, C. Nigro, Helmholtz Association, German Research Foundation, European Commission, Deutsches Elektronen-Synchrotron [Zeuthen] (DESY), Helmholtz-Gemeinschaft = Helmholtz Association, Max-Planck-Institut für Kernphysik (MPIK), Max-Planck-Gesellschaft, Landessternwarte Königstuhl [ZAH] (LSW), Universität Heidelberg [Heidelberg] = Heidelberg University, Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Dortmund [Dortmund] (TU), Department of Physics and Astronomy [UCLA, Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), McGill University = Université McGill [Montréal, Canada], Institut de Física d’Altes Energies [Barcelone] (IFAE), Universitat Autònoma de Barcelona (UAB), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, H.E.S.S., MAGIC, VERITAS, and FACT collaborations for releasing the data that were used.This work made use of astropy (Astropy Collaboration 2013) and sherpa (Freeman et al. 2001)., European Project: 653477,H2020,H2020-INFRADEV-1-2014-1,ASTERICS(2015), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg], Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), University of California-University of California, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Helmholtz-Gemeinschaft, Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Complutense University of Madrid (UCM), McGill University, and Universitat Autònoma de Barcelona [Barcelona] (UAB)
Subjects: Systematic error, Cherenkov Telescope Array, 01 natural sciences, HESS, data analysis [Methods], 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::Instrumentation and Methods for Astrophysics, imaging, Gamma-ray astronomy, error: statistical, Data format, upgrade, VERITAS, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, numerical calculations: Monte Carlo, on-line, data analysis method, Astrophysics::High Energy Astrophysical Phenomena, general [Gamma rays], FOS: Physical sciences, Cherenkov counter: atmosphere, programming, gamma ray: energy spectrum, GLAST, energy dependence, 0103 physical sciences, photomultiplier: silicon, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Common Data Format, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, Remote sensing, 010308 nuclear & particles physics, background, Magic (programming), Astronomy and Astrophysics, gamma rays: general, MAGIC, methods: data analysis, Crab Nebula, gamma ray: VHE, Space and Planetary Science, ddc:520, spectral, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: The analysis and combination of data from different gamma-ray instruments involves the use of collaboration proprietary software and case-by-case methods. The effort of defining a common data format for high-level data, namely event lists and instrument response functions (IRFs), has recently started for very-high-energy gamma-ray instruments, driven by the upcoming Cherenkov Telescope Array (CTA). In this work we implemented this prototypical data format for a small set of MAGIC, VERITAS, FACT, and H.E.S.S. Crab nebula observations, and we analyzed them with the open-source gammapy software package. By combining data from Fermi-LAT, and from four of the currently operating imaging atmospheric Cherenkov telescopes, we produced a joint maximum likelihood fit of the Crab nebula spectrum. Aspects of the statistical errors and the evaluation of systematic uncertainty are also commented upon, along with the release format of spectral measurements. The results presented in this work are obtained using open-access on-line assets that allow for a long-term reproducibility of the results.© ESO 2019., This work was supported by the Young Investigators Program of the Helmholtz Association, by the Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center SFB 876 >Providing Information by Resource-Constrained Analysis>, project C3 and by the European Commision through the ASTERICS Horizon2020 project (id 653477).
Published: 2019

41. Monte Carlo studies for the optimisation of the Cherenkov Telescope Array layout

Author: Katsuaki Asano, Rodrigo Guedes Lang, M. Cieślar, Nicholas F. H Tothill, Gianpiero Tagliaferri, O. Le Blanc, M. Vazquez Acosta, Nicola Giglietto, S. Mangano, Julien Lefaucheur, Tatsuo Yoshida, D. de Martino, Martin Pohl, A. Shalchi, Y. Renier, B. Biasuzzi, T. B. Humensky, E. Fiandrini, Andreas Quirrenbach, Abelardo Moralejo, Carla Aramo, Vincenzo Rizi, J. Knapp, A. Pagliaro, Andrea Santangelo, Michael Punch, Andreas Specovius, A. M. Lopez, P. Peñil Del Campo, Henry Przybilski, J.-P. Lenain, Agnieszka Slowikowska, Satoshi Fukami, M. H. Grondin, S. Schlenstedt, Marek Nikolajuk, F. Schüssler, Maria Concetta Maccarone, Michael Zacharias, Francesco Giordano, T. Suomijärvi, Lorenzo Amati, J. Becker Tjus, Maxim V. Barkov, H. Prokoph, F.G. Saturni, R. J. White, Nu. Komin, María Isabel Bernardos, M. Orienti, Denis Bastieri, Justin Vandenbroucke, P. Vallania, Diego Falceta-Gonçalves, L. Tibaldo, A. Burtovoi, A. Viana, Takanori Yoshikoshi, Roberto Aloisio, Soebur Razzaque, M. Valentino, P. Da Vela, Pol Bordas, Francesco Longo, N. Otte, V. La Parola, E. O. Angüner, Marco Berton, Elina Lindfors, Salvo Scuderi, Hiroyasu Tajima, M. Prouza, E. Mach, P. Goldoni, C. Alispach, M. I. Martínez, Miroslav Pech, Kai Brügge, G. Vasileiadis, A. Nagai, A. Brill, Dusan Mandat, Geoff Romeo, M. Marculewicz, Cameron B Rulten, Fuyuki Tokanai, Luis Ángel Tejedor, Thomas Lohse, Anderson Caproni, Karol Seweryn, G. Bonnoli, D. Ninci, G. Pareschi, Stefan Kimeswenger, I. Sadeh, Łukasz Stawarz, M. Nöthe, Daniel Mazin, Ruben Alfaro, G. Busetto, Massimo Persic, A. Berti, G. Sironi, Pavel Horvath, Włodek Kluźniak, Pietro Bruno, Petr Travnicek, Daniel Kerszberg, M. Hayashida, Tomasz Szepieniec, A. Rugliancich, Marina Manganaro, Y. Ohtani, Samuel Timothy Spencer, L. Di Venere, S. Karkar, M. Füßling, E. de Oña Wilhelmi, Louis Antonelli, M. Lemoine-Goumard, Benjamin Koch, P.-O. Petrucci, M. de Naurois, Felix Werner, S. Sakurai, J. J. Rodríguez Vázquez, Petr Janecek, L. Dangeon, G. Fontaine, Alison Mitchell, Maria Magdalena González, Francesco Dazzi, Philip Kaaret, Reinaldo Santos-Lima, F. Di Pierro, Tomislav Terzić, Grzegorz Kowal, Stefan Wagner, R. A. Cameron, G. S. Varner, M. Roncadelli, Wystan Benbow, C. Bonavolontà, David Kieda, M. A. Leigui de Oliveira, Ullrich Schwanke, Y. Iwamura, K. Sedlaczek, R. C. Shellard, Q. Feng, David A. Williams, A. De Angelis, T. Nagayoshi, P. Sangiorgi, I. A. Minaya, Etienne Lyard, Juan Abel Barrio, B. De Lotto, S. Nozaki, J. Gironnet, L. Mohrmann, Oscar Blanch, Marcello Giroletti, Jean-Luc Meunier, Valentina Fioretti, S. Masuda, V. Vagelli, Rodolfo Canestrari, L. Freixas Coromina, M. Palatka, T. Di Girolamo, Vincenzo Testa, Tsuguya Naito, J. Becerra González, R. Alves Batista, Samo Stanič, S. D. Vergani, Lorenzo Bellizzi, Catherine Boisson, Olivier Hervet, P. Cumani, Konstancja Satalecka, Stefan Funk, Michele Doro, Pedro L. Luque-Escamilla, P. Romano, E. Fedorova, Carlo Vigorito, M. Zavrtanik, Markus Gaug, Stanislav Stefanik, R. J. García López, F. de Palma, V. Beshley, T.R.N. Ekoume, Enrico Congiu, Pierre Brun, Manuela Mallamaci, Barbara Balmaverde, L. Valore, Gino Tosti, Enrico Cascone, Marek Jamrozy, V. I. Zhdanov, Gavin Rowell, Elisabetta Bissaldi, M. Fiori, M. Capalbi, J. Bregeon, Dario Hrupec, F. Toussenel, R. Paoletti, Fulvio Gianotti, Ayan Acharyya, G. Spengler, P. Majumdar, A.A. Zdziarski, A. López-Oramas, M. Mariotti, Juri Poutanen, G. Ferrand, Paweł Świerk, M. Garczarczyk, S. Rainò, Tsunefumi Mizuno, Diego F. Torres, Ciro Bigongiari, Matteo Cerruti, M. Polo, Csaba Balázs, A. Dmytriiev, T. Gasparetto, D. Dorner, A. W. Chen, Elisa Prandini, Vitalii Sliusar, Helene Sol, Rodolfo Carosi, Jonathan Biteau, Vito Conforti, G. Rodriguez Fernandez, Shanta M. Zimmer, J. M. Paredes, S. Vercellone, Jonathan Granot, Alice Donini, Antonio Stamerra, Jaime Rosado, Michael G. Burton, Bohdan Hnatyk, F. D'Ammando, D. Nosek, M. Heller, Gagik Tovmassian, N. Produit, Petr Schovanek, German Martinez, G. Pühlhofer, S. Fegan, A. Kong, G. Morlino, G. Emery, H.-S. Zechlin, Tomasz Bulik, Antonino D'Ai, Riccardo Rando, Rocco Lico, K. Pfrang, D. Hadasch, R. López-Coto, A. Vollhardt, Pankaj Kushwaha, Petar Temnikov, Emmanuel Moulin, Luca Zampieri, Michiko Ohishi, C. Maggio, V. de Souza, Q. Piel, Marc Ribó, Werner Hofmann, A. Wierzcholska, Luisa Arrabito, Gianpaolo Vettolani, J. Pérez-Romero, Paramita Barai, Sylvain Chaty, N. Parmiggiani, V. Vassiliev, K. Nishijima, D. Cauz, S. Caroff, Giuseppe Leto, J.F. Glicenstein, Maria Ionica, Eva Sciacca, A. Bonardi, Juan Carlos Rodríguez-Ramírez, Marcos Santander, H. Siejkowski, Daniela Maria Ribeiro, Ralph Bird, S. Mićanović, D. Zavrtanik, Carole Mundell, Jan Ebr, Koji Noda, Elisa Bernardini, R. Gnatyk, Pierre Jean, M. Nievas Rosillo, M. López, Olga Sergijenko, R. Walter, Oleh Petruk, M. Del Santo, D. Elsasser, Jakub Juryšek, H. Martínez-Huerta, Andreas Zech, Jose J. Gonzalez, Akira Okumura, M. Iori, A. Ghalumyan, Jacco Vink, David Gascon, Jürgen Knödlseder, Daniel Nieto, R. A. Ong, Sabrina Casanova, B. Khélifi, S. Flis, G. Galanti, H. J. Voelk, Jim Hinton, M. Will, David H. Green, Giuseppe Malaguti, B. Rudak, A. Pe'Er, J. L. Dournaux, Andrea Bulgarelli, Frank M. Rieger, A. Djannati-Ataï, F. De Frondat, Lenka Tomankova, Moritz Hütten, Osvaldo Catalano, Hidetoshi Kubo, Tarek M. Hassan, Tomohiro Inada, Farinaldo S. Queiroz, J. Kushida, Daniel Morcuende, Jose Luis Contreras, F. Salesa Greus, Juan Cortina, Andreu Sanuy, S. Vorobiov, G. Maneva, B. Vallage, N. Maxted, N. Renault-Tinacci, P. Munar, M. Seglar-Arroyo, Fabrizio Tavecchio, Z. Ou, Anatolii Zenin, T. Tam, Miroslav Hrabovsky, G. Ambrosi, Giovanni Bonanno, R. Millul, Anastasia Maria Barbano, T. Grabarczyk, J. Zorn, D. Dominis Prester, R. D. Parsons, Luis H. S. Kadowaki, Elena Amato, M. Lallena Arquillo, I. Oya, Jacek Niemiec, Gianluca Giavitto, Marita Krause, Olaf Reimer, Josep Martí, M. Perri, Maria Chernyakova, Takeshi Nakamori, E. M. de Gouveia Dal Pino, Thomas Murach, P. Cristofari, C. Delgado, Fernando Catalani, G. La Rosa, J. Alfaro, Thomas Armstrong, J. Kocot, Léa Jouvin, Markus Böttcher, Rodrigo Nemmen, J. P. Amans, Utane Sawangwit, Y. Kobayashi, Hidetoshi Sano, D. Jankowsky, Heide Costantini, F. Arqueros, B. Bertucci, Sebastian Diebold, L. P. Taylor, Konstantinos N. Gourgouliatos, A. Fiasson, Miroslav Filipovic, R. Moderski, T. Stolarczyk, B. Patricelli, H. Ashkar, Alessandro Costa, Jonathan Blazek, C. Trichard, M. Vecchi, T. Greenshaw, A. Morselli, V. Vitale, A. M. Brown, S. M. Colak, Lili Yang, C. Díaz, J. Rico, P. Caraveo, S. Loporchio, Orel Gueta, Daniele Gaggero, V. De Caprio, R. Wischnewski, A. Sillanpää, C. J. Todero Peixoto, Takashi Saito, I. Agudo, Yasuo Fukui, Roberto Capuzzo-Dolcetta, F. Cassol, Manuel Meyer, Reiko Orito, G. Umana, M. V. Fonseca, U. Barres de Almeida, Saverio Lombardi, D. della Volpe, Giancarlo Cusumano, M. Ostrowski, T. Montaruli, L. Tosti, Garret Cotter, Konrad Bernlöhr, Reshmi Mukherjee, Fabio Iocco, M. Palatiello, Jonathan S. Lapington, U. Straumann, R. de Cássia dos Anjos, Matteo Balbo, Lab Saha, N. Hiroshima, G. Chiaro, D. Tonev, Ermanno Pietropaolo, Atreyee Sinha, Ministerio de Ciencia e Innovación (España), European Commission, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Research unit Astroparticle Physics, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Acharyya, A., Agudo, I., Anguner, E. O., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Alves Batista, R., Amans, J. -P., Amati, L., Amato, E., Ambrosi, G., Antonelli, L. A., Aramo, C., Armstrong, T., Arqueros, F., Arrabito, L., Asano, K., Ashkar, H., Balazs, C., Balbo, M., Balmaverde, B., Barai, P., Barbano, A., Barkov, M., Barres de Almeida, U., Barrio, J. A., Bastieri, D., Becerra Gonzalez, J., Becker Tjus, J., Bellizzi, L., Benbow, W., Bernardini, E., Bernardos, M. I., Bernlohr, K., Berti, A., Berton, M., Bertucci, B., Beshley, V., Biasuzzi, B., Bigongiari, C., Bird, R., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Boisson, C., Bonanno, G., Bonardi, A., Bonavolonta, C., Bonnoli, G., Bordas, P., Bottcher, M., Bregeon, J., Brill, A., Brown, A. M., Brugge, K., Brun, P., Bruno, P., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Cameron, R., Canestrari, R., Capalbi, M., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, R., Casanova, S., Cascone, E., Cassol, F., Catalani, F., Catalano, O., Cauz, D., Cerruti, M., Chaty, S., Chen, A., Chernyakova, M., Chiaro, G., Cieslar, M., Colak, S. M., Conforti, V., Congiu, E., Contreras, J. L., Cortina, J., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cumani, P., Cusumano, G., D'Ai, A., D'Ammando, F., Dangeon, L., Da Vela, P., Dazzi, F., De Angelis, A., De Caprio, V., de Cassia dos Anjos, R., De Frondat, F., de Gouveia Dal Pino, E. M., De Lotto, B., De Martino, D., de Naurois, M., de Ona Wilhelmi, E., de Palma, F., de Souza, V., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Pierro, F., Di Venere, L., Diaz, C., Diebold, S., Djannati-Atai, A., Dmytriiev, A., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Dournaux, J. -L., Ebr, J., Ekoume, T. R. N., Elsasser, D., Emery, G., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Flis, S., Fonseca, M. V., Fontaine, G., Freixas Coromina, L., Fukami, S., Fukui, Y., Funk, S., Fussling, M., Gaggero, D., Galanti, G., Garcia Lopez, R. J., Garczarczyk, M., Gascon, D., Gasparetto, T., Gaug, M., Ghalumyan, A., Gianotti, F., Giavitto, G., Giglietto, N., Giordano, F., Giroletti, M., Gironnet, J., Glicenstein, J. -F., Gnatyk, R., Goldoni, P., Gonzalez, J. M., Gonzalez, M. M., Gourgouliatos, K. N., Grabarczyk, T., Granot, J., Green, D., Greenshaw, T., Grondin, M. -H., Gueta, O., Hadasch, D., Hassan, T., Hayashida, M., Heller, M., Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hofmann, W., Horvath, P., Hrabovsky, M., Hrupec, D., Humensky, T. B., Hutten, M., Inada, T., Iocco, F., Ionica, M., Iori, M., Iwamura, Y., Jamrozy, M., Janecek, P., Jankowsky, D., Jean, P., Jouvin, L., Jurysek, J., Kaaret, P., Kadowaki, L. H. S., Karkar, S., Kerszberg, D., Khelifi, B., Kieda, D., Kimeswenger, S., Kluzniak, W., Knapp, J., Knodlseder, J., Kobayashi, Y., Koch, B., Kocot, J., Komin, N., Kong, A., Kowal, G., Krause, M., Kubo, H., Kushida, J., Kushwaha, P., La Parola, V., La Rosa, G., Lallena Arquillo, M., Lang, R. G., Lapington, J., Le Blanc, O., Lefaucheur, J., Leigui de Oliveira, M. A., Lemoine-Goumard, M., Lenain, J. -P., Leto, G., Lico, R., Lindfors, E., Lohse, T., Lombardi, S., Longo, F., Lopez, A., Lopez, M., Lopez-Oramas, A., Lopez-Coto, R., Loporchio, S., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Mach, E., Maggio, C., Majumdar, P., Malaguti, G., Mallamaci, M., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Marculewicz, M., Mariotti, M., Marti, J., Martinez, M., Martinez, G., Martinez-Huerta, H., Masuda, S., Maxted, N., Mazin, D., Meunier, J. -L., Meyer, M., Micanovic, S., Millul, R., Minaya, I. A., Mitchell, A., Mizuno, T., Moderski, R., Mohrmann, L., Montaruli, T., Moralejo, A., Morcuende, D., Morlino, G., Morselli, A., Moulin, E., Mukherjee, R., Munar, P., Mundell, C., Murach, T., Nagai, A., Nagayoshi, T., Naito, T., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas Rosillo, M., Nikolajuk, M., Ninci, D., Nishijima, K., Noda, K., Nosek, D., Nothe, M., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Ong, R. A., Orienti, M., Orito, R., Ostrowski, M., Otte, N., Ou, Z., Oya, I., Pagliaro, A., Palatiello, M., Palatka, M., Paoletti, R., Paredes, J. M., Pareschi, G., Parmiggiani, N., Parsons, R. D., Patricelli, B., Pe'Er, A., Pech, M., Penil Del Campo, P., Perez-Romero, J., Perri, M., Persic, M., Petrucci, P. -O., Petruk, O., Pfrang, K., Piel, Q., Pietropaolo, E., Pohl, M., Polo, M., Poutanen, J., Prandini, E., Produit, N., Prokoph, H., Prouza, M., Przybilski, H., Puhlhofer, G., Punch, M., Queiroz, F., Quirrenbach, A., Raino, S., Rando, R., Razzaque, S., Reimer, O., Renault-Tinacci, N., Renier, Y., Ribeiro, D., Ribo, M., Rico, J., Rieger, F., Rizi, V., Rodriguez Fernandez, G., Rodriguez-Ramirez, J. C., Rodri-guez Vazquez, J. J., Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rowell, G., Rudak, B., Rugliancich, A., Rulten, C., Sadeh, I., Saha, L., Saito, T., Sakurai, S., Salesa Greus, F., Sangiorgi, P., Sano, H., Santander, M., Santangelo, A., Santos-Lima, R., Sanuy, A., Satalecka, K., Saturni, F. G., Sawangwit, U., Schlenstedt, S., Schovanek, P., Schussler, F., Schwanke, U., Sciacca, E., Scuderi, S., Sedlaczek, K., Seglar-Arroyo, M., Sergijenko, O., Seweryn, K., Shalchi, A., Shellard, R. C., Siejkowski, H., Sillanpaa, A., Sinha, A., Sironi, G., Sliusar, V., Slowikowska, A., Sol, H., Specovius, A., Spencer, S., Spengler, G., Stamerra, A., Stanic, S., Stawarz, L., Stefanik, S., Stolarczyk, T., Straumann, U., Suomijarvi, T., Swierk, P., Szepieniec, T., Tagliaferri, G., Tajima, H., Tam, T., Tavecchio, F., Taylor, L., Tejedor, L. A., Temnikov, P., Terzic, T., Testa, V., Tibaldo, L., Todero Peixoto, C. J., Tokanai, F., Tomankova, L., Tonev, D., Torres, D. F., Tosti, G., Tosti, L., Tothill, N., Toussenel, F., Tovmassian, G., Travnicek, P., Trichard, C., Umana, G., Vagelli, V., Valentino, M., Vallage, B., Vallania, P., Valore, L., Vandenbroucke, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Vazquez Acosta, M., Vecchi, M., Vercellone, S., Vergani, S., Vettolani, G. P., Viana, A., Vigorito, C. F., Vink, J., Vitale, V., Voelk, H., Vollhardt, A., Vorobiov, S., Wagner, S. J., Walter, R., Werner, F., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wischnewski, R., Yang, L., Yoshida, T., Yoshikoshi, T., Zacharias, M., Zampieri, L., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zenin, A., Zhdanov, V. I., Zimmer, S., Zorn, J., Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Durham University, Glorieta de la Astronomía s/n, Delegación Coyoacán, Pontificia Universidad Católica de Chile, Département de physique nucléaire et corpusculaire, Università degli Studi dell'Aquila and Gran Sasso Science Institute, Universidade de São Paulo (USP), PSL Research University, INAF - Osservatorio di astrofisica e scienza dello spazio di Bologna, INAF - Osservatorio Astrofisico di Arcetri, INFN Sezione di Perugia, Universitá degli Studi di Perugia, INAF - Osservatorio Astronomico di Roma, INFN Sezione di Napoli, University of Oxford, Universidad Complutense de Madrid, CNRS/IN2P3, University of Tokyo, Monash University, University of Geneva, INAF - Osservatorio Astronomico di Brera, Institute of Physical and Chemical Research, Centro Brasileiro de Pesquisas Físicas, INFN Sezione di Padova and Universitá degli Studi di Padova, Universidad de La Laguna, Ruhr-Universität Bochum, Harvard-Smithsonian Center for Astrophysics, Max-Planck-Institut für Kernphysik, INFN Sezione di Torino, Pidstryhach Institute for Applied Problems in Mechanics and Mathematics NASU, Université Paris-Saclay, University of California, INFN Sezione di Bari and Politecnico di Bari, The Barcelona Institute of Science and Technology, Institute of Physics of the Czech Academy of Sciences, INAF - Osservatorio Astrofisico di Catania, Radboud University Nijmegen, Dipartimento di Scienze Fisiche, IEEC-UB, North-West University, Columbia University, TU Dortmund University, University of Warsaw, Armagh Observatory and Planetarium, Stanford University, INAF - Istituto di Astrofisica Spaziale e Fisica Cosmica di Palermo, Núcleo de Astrofísica Teórica (NAT/UCS), INAF - Istituto di Astrofisica Spaziale e Fisica Cosmica di Milano, INFN Sezione di Pisa, Polish Academy of Sciences, INAF - Osservatorio Astronomico di Capodimonte, INFN Sezione di Trieste and Università degli Studi di Udine, University of the Witwatersrand, Dublin City University, CIEMAT, CPPM, INAF - Istituto di Radioastronomia, Cherenkov Telescope Array Observatory, Universidade Federal do Paraná (UFPR), Université Paris-Saclay), CSIC), Institut d'Estudis Espacials de Catalunya (IEEC), Institució Catalana de Recerca i Estudis Avançats (ICREA) Barcelona, INFN Sezione di Bari and Università degli Studi di Bari, Universität Tübingen, Obs de Paris, University of Rijeka, Universität Würzburg, LPNHE, Astronomical Observatory of Taras Shevchenko National University of Kyiv, Western Sydney University, INAF - Osservatorio Astronomico di Padova, Deutsches Elektronen-Synchrotron, Nagoya University, University of Amsterdam, Universidad Autónoma de Madrid, INFN Sezione di Trieste and Università degli Studi di Trieste, Universitat Autónoma de Barcelona, Yerevan Physics Institute, Universidad Andrés Bello UNAB, Academic Computer Centre CYFRONET AGH, The Open University of Israel, Max-Planck-Institut für Physik, Oliver Lodge Laboratory, UMR 5797, Konan University, KEK (High Energy Accelerator Research Organization), RCPTM, Josip Juraj Strossmayer University of Osijek, Universidade Estadual Paulista (Unesp), INFN Sezione di Roma, Jagiellonian University, Physikalisches Institut, Université Paul Sabatier, University of Iowa, Leopold-Franzens-Universität, Kyoto University, Tokai University, University of Leicester, Universidade Federal do ABC (UFABC), University of Turku, Humboldt University Berlin, Universidad de Jaén, Saha Institute of Nuclear Physics, Bulgarian Academy of Sciences, Faculty of Physics, University of New South Wales, Universität Zürich, Hiroshima University, INFN Sezione di Roma Tor Vergata, INAF - Istituto di Astrofisica e Planetologia Spaziali (IAPS), University of Bath, Saitama University, Yamanashi-Gakuin University, Yamagata University, Institute of Particle & Nuclear Physics, Tokushima University, Georgia Institute of Technology, Institut de Planétologie et d'Astrophysique de Grenoble, Univ. Savoie Mont Blanc, Universität Potsdam, Linnaeus University, Universität Heidelberg, University of Johannesburg, University of Adelaide, Tuscaloosa, National Astronomical Research Institute of Thailand, Dept of Physics and Astronomy, Nicolaus Copernicus University, University of Nova Gorica, University of Wisconsin, INAF - Osservatorio Astrofisico di Torino, University of Hawai'i at Manoa, Ibaraki University, KVI - Center for Advanced Radiation Technology, University of Utah, USA, GBR, FRA, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Angüner, E. O., Becerra González, J., Bernlöhr, K., Bonavolontá, C., Böttcher, M., Brügge, K., Cieślar, M., D’Aí, A., D’Ammando, F., de Cássia dos Anjos, R., de Oña Wilhelmi, E., Díaz, C., Djannati-Ataï, A., Elsässer, D., Füßling, M., Garcia López, R. J., González, J. M., González, M. M., Hütten, M., Khélifi, B., Kluźniak, W., Knödlseder, J., López, M., López-Coto, R., Martí, J., Martínez, M., Martínez, G., Martínez-Huerta, H., Nikołajuk, M., Nöthe, M., Pe’Er, A., Peñil Del Campo, P., Pérez-Romero, J., Pühlhofer, G., Rainò, S., Ribó, M., Rodrí-guez Vázquez, J. J., Sillanpää, A., Stanič, S., Stawarz, Ł., Świerk, P., Vázquez Acosta, M., GRAPPA (ITFA, IoP, FNWI), and High Energy Astrophys. & Astropart. Phys (API, FNWI)
Subjects: Cherenkov Telescope Array, Astronomy, Monte Carlo method, energy resolution, Monte Carlo simulations, Cherenkov telescopes, IACT technique, gamma rays, cosmic rays, 01 natural sciences, 7. Clean energy, law.invention, Observatory, law, site, Monte Carlo, 010303 astronomy & astrophysics, Physics, Astrophysics::Instrumentation and Methods for Astrophysics, observatory, Cosmic rays, Gamma rays, Astronomy and Astrophysics, ddc:540, Física nuclear, Monte carlo studies, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, performance, FÍSICA DE ALTA ENERGIA, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, FOS: Physical sciences, energy dependence, Telescope, Optics, CTA - Abteilung Hofmann, 0103 physical sciences, Cherenkov counter: imaging, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), Monte Carlo simulation, Cherenkov radiation, CTA, 010308 nuclear & particles physics, business.industry, sensitivity, Cosmic ray, Cherenkov telescope, gamma ray: VHE, business, Energy (signal processing), astro-ph.IM
Abstract: The Cherenkov Telescope Array (CTA) is the major next-generation observatory for ground-based very-high-energy gamma-ray astronomy. It will improve the sensitivity of current ground-based instruments by a factor of five to twenty, depending on the energy, greatly improving both their angular and energy resolutions over four decades in energy (from 20 GeV to 300 TeV). This achievement will be possible by using tens of imaging Cherenkov telescopes of three successive sizes. They will be arranged into two arrays, one per hemisphere, located on the La Palma island (Spain) and in Paranal (Chile). We present here the optimised and final telescope arrays for both CTA sites, as well as their foreseen performance, resulting from the analysis of three different large-scale Monte Carlo productions.© 2019, We gratefully acknowledge financial support from the following agencies and organizations: State Committee of Science of Armenia, Armenia; The Australian Research Council, Astronomy Australia Ltd, The University of Adelaide, Australian National University, Monash University, The University of New South Wales, The University of Sydney, Western Sydney University, Australia; Federal Ministry of Science, Research and Economy, and Innsbruck University, Austria; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Ministry of Science, Technology, Innovations and Communications (MCTIC), Brasil; Ministry of Education and Science, National RI Roadmap Project D01-153/28.08.2018, Bulgaria; The Natural Sciences and Engineering Research Council of Canada and the Canadian Space Agency, Canada; CONICYT-Chile grants PFB-06, FB0821, ACT 1406, FONDECYT-Chile grants 3160153, 3150314, 1150411, 1161463, 1170171, Pontificia Universidad Catolica de Chile Vice-Rectory of Research internationalization grant under MINEDUC agreement PUC1566, Chile, Croatian Science Foundation, Rudjer Boskovic Institute, University of Osijek, University of Rijeka, University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, University of Zagreb, Faculty of Electrical Engineering and Computing, Croatia; Ministry of Education, Youth and Sports, MEYS LM2015046, LTT17006 and EU/MEYS CZ.02.1.01/0.0/0.0/16_013/0001403, CZ.02.1.01/0.0/0.0/17_049/0008422, Czech Republic; Ministry of Higher Education and Research, CNRS-INSU and CNRS-IN2P3, CEA-Irfu, ANR, Regional Council Ile-de France, Labex ENIGMASS, OSUG2020, P210 and OCEVU, France; Max Planck Society, BMBF, DESY, Helmholtz Association, Germany; Department of Atomic Energy, Department of Science and Technology, India; Istituto Nazionale di Astrofisica (INAF), Istituto Nazionale di Fisica Nucleare (INFN), MIUR, Istituto Nazionale di Astrofisica (INAF-OABRERA) Grant Fondazione Cariplo/Regione Lombardia ID 2014-1980/RST_ERC, Italy; ICRR, University of Tokyo, JSPS, MEXT, Japan; Netherlands Research School for Astronomy (NOVA), Netherlands Organization for Scientific Research (NWO), Netherlands; University of Oslo, Norway; Ministry of Science and Higher Education, DIR/WK/2017/12, the National Centre for Research and Development and the National Science Centre, UMO-2016/22/M/ST9/00583, Poland; Slovenian Research Agency, Slovenia, grants P1-0031, P1-0385, 10-0033, J1-9146; South African Department of Science and Technology and National Research Foundation through the South African Gamma-Ray Astronomy Programme, South Africa; MINECO National R+D+I, Severo Ochoa, Maria de Maeztu, CDTI, PAIDI, UJA, FPA2017-90566-REDC, Spain; Swedish Research Council, Royal Physiographic Society of Lund, Royal Swedish Academy of Sciences, The Swedish National Infrastructure for Computing (SNIC) at Lunarc (Lund), Sweden; Swiss National Science Foundation (SNSF), Ernest Boninchi Foundation, Switzerland; Durham University, Leverhulme Trust, Liverpool University, University of Leicester, University of Oxford, Royal Society, Science and Technology Facilities Council, UK; U.S. National Science Foundation, U.S.Department of Energy, Argonne National Laboratory, Barnard College, University of California, University of Chicago, Columbia University, Georgia Institute of Technology, Institute for Nuclear and Particle Astrophysics (INPAC-MRPI program), Iowa State University, the Smithsonian Institution, Washington University McDonnell Center for the Space Sciences, The University of Wisconsin and the Wisconsin Alumni Research Foundation, USA. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreements no 262053 and no 317446. This project is receiving funding from the European Union's Horizon 2020 research and innovation programs under agreement no 676134.
Published: 2019

42. Ceramide 1 phosphate is a potent chemoattractant factor of endothelial colony forming cells and improve post ischemia tissue regeneration

Author: Mena, Hebe A., Paula Romina Zubiry, Blandine Dizier, Mirta Schattner, Catherine Boisson-Vidal, Soledad Negrotto, Boisson-Vidal, Catherine, Laboratory of Experimental Thrombosis [Buenos Aires, Argentina] (IMEX), National Academy of Medicine-Institute of Experimental Medicine (IMEX), Innovations thérapeutiques en hémostase (IThEM - U1140), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Laboratory of Experimental Thrombosis (IMEX)
Subjects: [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract: International audience; Ceramide 1 phosphate (C1P) is a well-known chemotaxis inductor in macrophages and murine progenitor cells. In endothelial colony forming cells (ECFC), we have shown that C1P improved proliferation and tubule formation, although C1P chemotactic effects remain unknown. Considering that, C1P levels are elevated in ischemic tissues and that ECFC migration is a key step post-ischemia tissue revascularization, we here aimed to study whether C1P is an ECFC chemoattractant factor and improve their revascularization abilities in vivo. Human cord blood-derived CD34+ cells were cultured in EGM2 and, after 14-18 days, ECFC colonies were obtained. ECFC were treated with C1P short chain analog C8-C1P. N=3-6, p
Published: 2019

43. Combined Dark Matter searches towards dwarf spheroidal galaxies with Fermi-LAT, HAWC, HESS, MAGIC and VERITAS

Author: Dirk Lennarz, Luis Villaseñor, Gernot Maier, Anne Lemiere, Daniel Rosa-Gonzalez, Samuel Timothy Spencer, Wystan Benbow, Victor Barbosa Martins, Raul Prado, Arache Djannati-Ataï, Regis Terrier, Dan Parsons, Francisco Salesa Greus, Dmitriy Kostunin, Joshua Wood, Carlo Romoli, César Alvarez, Carlo van Rensburg, Massimo Capasso, Sajan Kumar, P. Reichherzer, Anton Dmytriiev, Stefan Ohm, Chiara Giuri, Brian van Soelen, G. Peron, Christian Stegmann, Emma Ona-Wilhelmi, S. J. Fegan, Alison Peisker, Hawc, Garret Cotter, Gary Gillanders, Zhiqiu Huang, Krzysztof Katarzynski, Filiberto Hueyotl-Zahuantitla, Ian Herzog, D. A. Prokhorov, K. Kosack, Halim Ashkar, Fabian Leuschner, Manami Sasaki, Michael Schneider, Joe Lundeen, Markus Boettcher, Brian Humensky, Isak Delberth Davids, A. Fiasson, Stefan Wagner, Andreas Zech, Yasunobu Uchiyama, David Kieda, Michael DuVernois, Albert Seyffert, Gianluca Giavitto, Qi Feng, Andreas Specovius, Andrew James Smith, Catherine Boisson, L. Mohrmann, Roberta Zanin, Marek Jamrozy, Tomás Capistrán Rojas, K. Nakashima, Jamie Holder, Hao Zhou, Thomas Lohse, Mireia Nievas-Rosillo, Samuel Zouari, Ira Jung, Sebastian Panny, K. Bernloehr, Deivid Ribeiro, Andrea Santangelo, Kristi Engel, Josefa Becerra Gonzalez, Thomas Tavernier, Ke Fang, Rishi Babu, Yu Wun Wong, Gerd J. Kunde, Jean-Pierre Ernenwein, Henrike Fleischhack, P. T. O'Brien, Clemens Hoischen, A. A. Zdziarski, Kelly Malone, Helene Sol, Markus Holler, Manel Errando, Atreyee Sinha, Francois Brun, Heinrich J. Völk, Sumari Hattingh, Kirsten Tollefson, Johann van der Walt, Q. Remy, Felix Jankowsky, Samridha Kunwar, Johannes Veh, M. Fuessling, P. Vincent, Harm Schoorlemmer, Stefano Gabici, Miguel Mostafa, Tyler Williamson, Jacek Niemiec, Michal Ostrowski, J.-P. Lenain, Israel Martinez Castellanos, Felix Aharonian, Tadayuki Takahashi, Gerd Puehlhofer, Lei Sun, Jesús Martínez-Castro, Pooja Surajbali, Andrés Sandoval, Hugh Spackman, Takaaki Tanaka, Segev BenZvi, Alexandre Marcowith, Felix Werner, Olaf Reimer, Vincent Marandon, Alberto Carramiñana, S. Steinmassl, Mary Kertzman, Hannes Thiersen, Victor Doroshenko, Michael Backes, Hannah Jhee, G. Lamanna, Marcos Santander, Angel Noel, W. Jin, Gus Sinnis, B. Rudak, Alasdair E. Gent, Kathrin Egberts, Jonathan Mackey, Fernando Ureña-Mena, Paolo Marchegiani, Sonal Ramesh Patel, Laenita Lorraine Oberholzer, Tim Holch, Sami Caroff, Heiko Salzmann, E. Kasai, Alison Mitchell, Gregory Foote, Nukri Komin, Tom Armstrong, Michelle Hui, Ruo-Yu Shang, Binita Hona, Raquel Diaz Hernandez, Vardan Baghmanyan, Celine Armand, Alejandro Lara, David Berley, Hector Rueda Ricarte, Nissim Illich Fraija, Naomi Tsuji, Gaurang Yodh, Stefan Funk, Alicja Wierzcholska, Conor McGrath, Gerard Fontaine, C. Moore, Vikas Joshi, Dorit Glawion, T. Chand, M. U. Nisa, M.-H. Grondin, Arnaud Mares, David Sanchez, Ernesto Belmont-Moreno, Thomas Murach, Eucario Gonzalo Pérez Pérez, Paul Reynolds, Ignacio Taboada, Xiaojie Wang, Lucy Fortson, Martin Tluczykont, Thomas Brian Humensky, Juan de Dios Álvarez Romero, Robert Ellsworth, Hester Schutte, Justine Devin, Constantin Steppa, Richard White, Rachel Simoni, Karen S. Caballero Mora, Elisa Pueschel, Jason Fan, Tomasz Bulik, Lukas Nellen, Malgorzata Curlo, Lente Dreyer, J. Patrick Harding, Gilles Maurin, Humberto Martínez Huerta, Riaan Steenkamp, Arnulfo Zepeda, Johannes Schaefer, Werner Hofmann, Jim Hinton, Michael Punch, S. Sailer, Dmitry Khangulyan, Sergio Hernández Cadena, Charles Thorpe-Morgan, M. Hörbe, Stephan O'Brien, Ramin Marx, John L. Quinn, J. F. Glicenstein, V. Sahakian, M. Panter, Mora Durocher, U. Katz, Jacco Vink, Umberto Cotti, Tobias Kleiner, Petra Hüntemeyer, David Huber, Ullrich Schwanke, Diego Garcia Aguilar, Vladimir Vassiliev, Oscar Martinez, J. Bolmont, Cederik León de León, Brian Fick, Laura Olivera-Nieto, A. Yusafzai, David Hanna, James Buckley, Lorenzo Diaz, Yves Gallant, Guillermo García-Torales, Arun Babu Kollamparambil, James Ryan, Kayla Farrell, Sabrina Casanova, Bruno Khelifi, María Catalina Espinoza Hernández, Jorge Antonio Morales Soto, Mateo Fernandez Alonso, Matthew Lundy, Faical Ait-Benkhali, Jean Damascene Mbarubucyeye, Wlodek Kluzniak, Jorge Luis Flores, Ibrahim Torres, Jordan A. Goodman, Anita Reimer, Adam Otte, Eduardo Moreno Barbosa, M. J. Lang, Frank M. Rieger, Elijah Willox, Colin Adams, Pedro Miranda-Romagnoli, Louis Du Plessis, Andrea Albert, Orel Gueta, Anna Barnacka, Brenda Dingus, Gašper Kukec Mezek, Hazal Goksu, Jorge Cotzomi, William H. Lee, Ruben Alfaro, Glenn Sembroski, David A. Williams, Eduardo de la Fuente, Anu Kundu, Dezhi Huang, Brian Reville, Connor Duffy, Edna Ruiz-Velasco, Anna Luashvili, Alisha Chromey, Konstantin Pfrang, L. Giunti, Philip Kaaret, Maria Magdalena González, Olivier Hervet, Hermes Leon Vargas, Sébastien Le Stum, Amanda Weinstein, Aryeh Brill, James Davies, Ken Ragan, Santiago Pita, Juan Carlos Arteaga Velazquez, Jason Lee, Sabrina Einecke, Lukasz Stawarz, Iryna Lypova, Julie McEnery, Sara Coutiño de Leon, Dieter Horns, R. J. Tuffs, Christo Venter, Meghan Tanner, Monica Barnard, B. Bi, Yvonne Becherini, Colas Rivière, Iftach Sadeh, Lott Frans, Mischa Breuhaus, Pauline Chambery, C. Levy, Jose Luis García-Luna, Michelle Tsirou, D. Malyshev, Ramiro Torres Escobedo, Hassan Abdalla, Hambeleleni Ndiyavala, Chang Dong Rho, Jhilik Majumdar, Martin Pohl, Mathieu Bony, Oguzhan Anguener, Hend Yassin, Gwenael Giacinti, Manuel Meyer, Arturo Iriarte, John Matthews, Kirsty Feijen, Ahron S. Barber, Floriane Cangemi, Fernando Garfias, R. A. Ong, Thomas Weisgarber, Thomas Bylund, Gilgamesh Luis-Raya, Rowan Batzofin, Mathieu Naurois, Jacques Muller, Avery Archer, Andreas Quirrenbach, Anushka Udara Abeysekara, José Serna-Franco, Hugo Alberto Ayala Solares, Davit Zargaryan, Rubén López-Coto, Reshmi Mukherjee, Andreas Zmija, Guillem Marti'i-Devesa, Sameer Patel, M. Lemoine-Goumard, Roberto Noriega-Papaqui, Gaëtan Fichet de Clairfontaine, Axel Donath, A. W. Chen, Michael Kreter, Yunior Pérez Araujo, Anna Lia Longinotti, Michael Zacharias, Kleopas Shiningayamwe, Robert Brose, Fabian Schüssler, Emmanuel Moulin, Patrick Moriarty, Edna Ruiz Velasco, Michael Newbold, Oscar Chaparro-Amaro, J. T. Linnemann, Lenka Tomankova, Jodi Christiansen, Jaqueline Catalano, Ian James Watson, R. Konno, Andrew Taylor, C. Arcaro, Jason John Watson, Gavin Rowell, Daniel Omar Avila Rojas, Denys Malyshev, Emmet Roache, Rhiannon Turner, Chad Brisbois, Mohanraj Senniappan, José Roberto Angeles Camacho, Daniel Nieto, V. Poireau, Jimmy N.S. Shapopi, G. Vasileiadis, Hannah Dalgleish, donggeun tak, Juan Carlos Díaz Vélez, Armelle Jardin-Blicq, N. Zywucka, Abe Falcone, Nicola Omodei, Matthieu Renaud, German Hermann, Paul Morris, Maria Haupt, Stefan Klepser, Christopher van Eldik, Rafal Moderski, Alessandro Montanari, Amy Furniss, Sylvia Zhu, P. J. Meintjes, David Berge, Jose Andres Garcia-Gonzalez, Humberto Ibarguen Salazar, Wayne Robert Springer, Heike Prokoph, Marion Spir-Jacob, Amid Nayerhoda, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'Annecy de Physique des Particules (LAPP), Fermi-LAT, HAWC, H.E.S.S., MAGIC, and VERITAS
Subjects: Cherenkov detector, air, Cherenkov counter: water, Physics beyond the Standard Model, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, satellite, FOS: Physical sciences, IACT, Astrophysics, 01 natural sciences, GLAST, dark matter, law.invention, law, HESS, 0103 physical sciences, 010306 general physics, Cherenkov radiation, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Annihilation, 010308 nuclear & particles physics, background, new physics, imaging, sensitivity, MAGIC, Galaxy, Automatic Keywords, annihilation, VERITAS, galaxy, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], statistical, HAWC, Fermi Gamma-ray Space Telescope
Abstract: 36th International Cosmic Ray Conference, ICRC2019, Madison, USA, 24 Jul 2019 - 1 Aug 2019; 9 pages (2019)., The search for Dark Matter (DM) has great potential to reveal physics beyond the Standard Model. As such, searches for evidence of DM particles are being carried out using a wide range of techniques, such as direct searches for DM particles, searches for DM produced with colliders, and indirect searches for the Standard Model annihilation products of DM. Dwarf spheroidal galaxies (dSphs) are excellent targets for indirect Dark Matter searches due to their relatively high DM content and negligible expected astrophysical background. A collaboration was formed to maximise the sensitivity of DM searches towards dSphs by combining for the first time dSph data from three imaging air Cherenkov telescope (IACT) arrays: HESS, MAGIC, and VERITAS; the Fermi-LAT satellite, and the water Cherenkov detector HAWC. Due to the diverse nature of the instruments involved, each experiment will analyse their individual datasets from multiple targets and then the results will be combined at the likelihood level. For consistency of the likelihoods across the five experiments, a common approach is used to treat the astrophysical factor (J-Factor) for each target and an agreed set of annihilation channels are considered. We also agree on a common statistical approach and treatment of instrumental systematic uncertainties. The results are presented in terms of constraints on the velocity-weighted cross section for DM self-annihilation as a function of the DM particle mass.
Published: 2019
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44. In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia

Author: Lukshe Kanagaratnam, Rida Al-Rifai, Caroline François, Gael Poitevin, Claire Tournois, Philippe Nguyen, Marie-Antoinette Sevestre, Catherine Boisson-Vidal, Christine Terryn, Nicole Bouland, Hémostase et Remodelage Vasculaire Post-Ischémie (HERVI - EA 3801), Université de Reims Champagne-Ardenne (URCA), Centre Hospitalier Universitaire de Reims (CHU Reims), Plateforme en Imagerie Cellulaire et Tissulaire (PICT), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Innovations thérapeutiques en hémostase (IThEM - U1140), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Champagne Ardenne region
Subjects: 0301 basic medicine, CD31, Male, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Angiogenesis, Organogenesis, lcsh:Medicine, Cell therapy, 0302 clinical medicine, Ischemia, Medicine, Cells, Cultured, Mice, Inbred BALB C, Muscles, Critical limb ischemia, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, General Medicine, Arteries, Middle Aged, Hindlimb, 030220 oncology & carcinogenesis, Female, Adult, Mice, Nude, Neovascularization, Physiologic, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Mesenchymal Stem Cell Transplantation, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, In vivo, Animals, Humans, Aged, Cluster of differentiation, business.industry, Regeneration (biology), Research, Mesenchymal stem cell, lcsh:R, Endothelial Cells, Extremities, Culture Media, 030104 developmental biology, Regional Blood Flow, Cancer research, Mesenchymal stem cells, Arteriogenesis, business
Abstract: Background Cell therapy has been proposed for patients with critical limb ischemia (CLI). Autologous bone marrow derived cells (BMCs) have been mostly used, mesenchymal stem cells (MSCs) being an alternative. The aim of this study was to characterize two types of MSCs and evaluate their efficacy. Methods MSCs were obtained from CLI-patients BMCs. Stimulated- (S-) MSCs were cultured in endothelial growth medium. Cells were characterized by the expression of cell surface markers, the relative expression of 6 genes, the secretion of 10 cytokines and the ability to form vessel-like structures. The cell proangiogenic properties was analysed in vivo, in a hindlimb ischemia model. Perfusion of lower limbs and functional tests were assessed for 28 days after cell infusion. Muscle histological analysis (neoangiogenesis, arteriogenesis and muscle repair) was performed. Results S-MSCs can be obtained from CLI-patients BMCs. They do not express endothelial specific markers but can be distinguished from MSCs by their secretome. S-MSCs have the ability to form tube-like structures and, in vivo, to induce blood flow recovery. No amputation was observed in S-MSCs treated mice. Functional tests showed improvement in treated groups with a superiority of MSCs and S-MSCs. In muscles, CD31+ and αSMA+ labelling were the highest in S-MSCs treated mice. S-MSCs induced the highest muscle repair. Conclusions S-MSCs exert angiogenic potential probably mediated by a paracrine mechanism. Their administration is associated with flow recovery, limb salvage and muscle repair. The secretome from S-MSCs or secretome-derived products may have a strong potential in vessel regeneration and muscle repair. Trial registration NCT00533104
Published: 2019

45. Downregulation of Microparticle Release and Pro-Inflammatory Properties of Activated Human Polymorphonuclear Neutrophils by LMW Fucoidan

Author: Marcel Menezes da Cunha, João Alfredo Moraes, Claudia F. Benjamim, Catherine Boisson-Vidal, Ana Clara Frony, Pedro Barcellos-de-Souza, Thayanne B. B. Calcia, Christina Barja-Fidalgo, Laboratorio de Farmacologia Celular e Molecular [Rio de Janeiro, Brazil], Universidade do Estado do Rio de Janeiro [Rio de Janeiro] (UERJ), Nucleo Multidisciplinar de Pesquisa em Biologia-NUMPEX-BIO [Xerém, Brazil], Universidade Federal do Rio de Janeiro (UFRJ), laboratério de lmunologia Molecular [Rio de Janeiro, Brazil], Innovations thérapeutiques en hémostase (IThEM - U1140), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), laboratorio de Biologia RedOx [Rio de Janeiro, Brazil], Université Sorbonne Paris Cité (USPC), This work was supported by grants from the Fundaçao de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ: E-26/202.782/2017), Coordenaçâo de Aperfeiçoamento de Pessoa! de Nivel Superior (CAPES) (Finance Code 001) and Conselho Nacional de Desenvolvimento Cientffi.co e Tecnol6gico (CNPq:302413/2017-0)., Boisson-Vidal, Catherine, and Universidade Federal do Rio de Janeiro [Rio de Janeiro] (UFRJ)
Subjects: 0301 basic medicine, Lipopolysaccharides, Lipopolysaccharide, Cell Survival, Neutrophils, Inflammation, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Phaeophyta, Extracellular Traps, Neutrophil Activation, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Cell-Derived Microparticles, Polysaccharides, medicine, Extracellular, Immunology and Allergy, Animals, Humans, L-Selectin, Autocrine signalling, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Cells, Cultured, chemistry.chemical_classification, reactive oxygen species, microparticles, Reactive oxygen species, Mice, Inbred BALB C, Fucoidan, Chemotaxis, polymorphonuclear neutrophils, hemic and immune systems, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Immunity, Innate, Cell biology, N-Formylmethionine Leucyl-Phenylalanine, Oxidative Stress, 030104 developmental biology, 030228 respiratory system, chemistry, inflammation, medicine.symptom, LMW fucoidan, Signal Transduction
Abstract: Exposition of neutrophils (polymorphonuclear neutrophils, PMNs) to bacterial products triggers exacerbated activation of these cells, increasing their harmful effects on host tissues. We evaluated the possibility of interfering with the classic immune innate responses of human PMNs exposed to bacterial endotoxin (lipopolysaccharide, LPS), and further stimulated with bacterial formyl peptide (N-formyl-methionine-leucine-phenylalanine, fMLP). We showed that the low- molecular-weight fucoidan (LMW-Fuc), a polysaccharide extracted from brown algae, attenuated the exacerbated activation induced by fMLP on LPS-primed PMNs, in vitro, impairing chemotaxis, NET formation, and the pro-survival and pro-oxidative effects. LMW-Fuc also inhibited the activation of canonical signaling pathways, AKT, bad, p47phox and MLC, activated by the exposition of PMN to bacterial products. The activation of PMN by sequential exposure to LPS and fMLP induced the release of L-selectin+ microparticles, which were able to trigger extracellular reactive oxygen species production by fresh PMNs and macrophages. Furthermore, we observed that LMW-Fuc inhibited microparticle release from activated PMN. In vivo experiments showed that circulating PMN-derived microparticles could be detected in mice exposed to bacterial products (LPS/fMLP), being downregulated in animals treated with LMW-Fuc. The data highlight the autocrine and paracrine role of pro-inflammatory microparticles derived from activated PMN and demonstrate the anti-inflammatory effects of LMW-Fuc on these cells.
Published: 2018

46. Type 2 diabetes alters mesenchymal stem cell secretome composition and angiogenic properties

Author: Guavri Caliaperoumal, Jonathan Ribot, Fani Anagnostou, Catherine Boisson-Vidal, Joseph Paquet, Hervé Petite, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Bioingénierie et Bioimagerie Ostéo-articulaires, Biomécanique et Biomatériaux Ostéo-Articulaires (B2OA (UMR_7052)), École nationale vétérinaire - Alfort (ENVA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Innovations thérapeutiques en hémostase (IThEM - U1140), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA), Service d’Odontologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Biomécanique et Biomatériaux Ostéo-Articulaires ( B2OA ), Université Paris Diderot - Paris 7 ( UPD7 ) -Ecole Nationale Vétérinaire d'Alfort-Centre National de la Recherche Scientifique ( CNRS ), Innovations thérapeutiques en hémostase ( IThEM - U1140 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Université Pierre et Marie Curie - Paris 6 ( UPMC ), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), HAL UPMC, Gestionnaire, Service d'Odontologie = Service de médecine Bucco-dentaire [CHU Pitié-Salpêtrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: Male, Proteomics, 0301 basic medicine, Proteome, endocrine system diseases, Angiogenesis, MSCs, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Type 2 diabetes, Extracellular matrix, angiogenesis, 0302 clinical medicine, Cell Movement, Insulin-Like Growth Factor I, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Extracellular Matrix Proteins, [ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, endothelial cells, Endothelial stem cell, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, medicine.medical_specialty, Cell Survival, Mice, Nude, Neovascularization, Physiologic, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Diabetes Mellitus, Experimental, 03 medical and health sciences, In vivo, Internal medicine, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Human Umbilical Vein Endothelial Cells, medicine, Animals, Cell Proliferation, diabetes type 2, Gene Expression Profiling, Mesenchymal stem cell, [ SDV.BC.BC ] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], nutritional and metabolic diseases, Mesenchymal Stem Cells, Original Articles, Cell Biology, medicine.disease, In vitro, Rats, Zucker, secretome, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Culture Media, Conditioned, Bone marrow, Reactive Oxygen Species
Abstract: International audience; This study aimed at characterizing the impact of type 2 diabetes mellitus (T2DM) on the bone marrow mesenchymal stem cell (BMMSC) secre-tome and angiogenic properties. BMMSCs from Zucker diabetic fatty rats (ZDF) (a T2DM model) and Zucker LEAN littermates (control) were cultured. The supernatant conditioned media (CM) from BMMSCs of diabetic and control rats were collected and analysed. Compared to results obtained using CM from LEAN-BMMSCs, the bioactive content of ZDF-BMMSC CM (i) differently affects endothelial cell (HUVEC) functions in vitro by inducing increased (3.5-fold; P < 0.01) formation of tubule-like structures and migration of these cells (3-fold; P < 0.001), as well as promotes improved vascular formation in vivo, and (ii) contains different levels of angiogenic factors (e.g. IGF1) and mediators, such as OSTP, CATD, FMOD LTBP1 and LTBP2, which are involved in angiogenesis and/or extracellular matrix composition. Addition of neutralizing antibodies against IGF-1, LTBP1 or LTBP2 in the CM of BMMSCs from diabetic rats decreased its stimulatory effect on HUVEC migration by approximately 60%, 40% or 40%, respectively. These results demonstrate that BMMSCs from T2DM rats have a unique secretome with distinct angiogenic properties and provide new insights into the role of BMMSCs in aberrant angiogenesis in the diabetic milieu.
Published: 2016

47. Osteoprotegerin induces CD34 + differentiation in Endothelial Progenitor Cells

Author: Catherine Boisson-Vidal, Zahia Benslimane-Ahmim, Anna Lokajczyk, Dominique Heymann, David M. Smadja, Innovations thérapeutiques en hémostase (IThEM - U1140), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Université Paris Descartes - Faculté de Pharmacie de Paris (UPD5 Pharmacie), Université Paris Descartes - Paris 5 (UPD5), Apoptosis and Tumor Progression (CRCINA-ÉQUIPE 9), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Service d'hématologie A [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), ZB-A received grants from the Groupe d’Etude et de Recherches sur l’Hémostase (GEHT). The CNRS pays the salary of CB-V., Heymann, Dominique, and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
Subjects: 0301 basic medicine, musculoskeletal diseases, proliferation, CD34, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.CAN] Life Sciences [q-bio]/Cancer, Osteoprotegerin, In vivo, Progenitor cell, Clonogenic assay, endothelial progenitor cells, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, CD34 + cells, lcsh:R5-920, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, General Medicine, endothelial-colony forming cells, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, CD34+ cells, Endothelial stem cell, 030104 developmental biology, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Cell culture, osteoprotegerin, Cord blood, Cancer research, lcsh:Medicine (General)
Abstract: International audience; Endothelial progenitor cells (EPCs) are the main hypothetical cells that could give rise to vessels and in particular one subtype isolated from peripheral or cord bloods: endothelial colony forming cells (ECFCs). These ECFCs are clonogenic precursors committed to endothelial lineage and have robust vasculogenic properties. However, their low number and poor expansion properties when isolated from human adult bloods, currently limit their use as an autologous cell therapy product. We previously reported that osteoprotegerin (OPG), a well-characterized regulator of bone metabolism, contributes to ischemic tissue revascularization, tumor growth in vivo, and potentiates ECFCs proangiogenic properties through the secretion of SDF-1. The current study investigated the role of OPG in ECFCs differentiation and expansion from cord blood CD34+ cells. OPG increased the number of ECFCs after endothelial differentiation of CD34+ cells, enhancing the time of EPCs colonies initial appearance and the growth kinetic of endothelial cell progeny. OPG-exposed ECFCs expressed higher levels of CD34+ compared to control ECFCs. In conclusion, our findings provide novel insights into OPG in regulation of CD34+ progenitor cells. These results give new opportunities for ex vivo expansion of human ECFCs using OPG as a cell culture component for future ECFC product manufacture according to GMP.
Published: 2018

48. VHE γ-ray discovery and multi-wavelength study of the blazar 1ES 2322-409

Author: M. Zacharias, Marek Jamrozy, Jim Hinton, A. Schulz, R. Tuffs, R. Simoni, Dmitry Khangulyan, D. A. Sanchez, Helene Sol, H. Ndiyavala, S. Bernhard, J. Devin, M. Böttcher, F. Ait Benkhali, S. Eschbach, C. Stegmann, Nu. Komin, M. Holler, B. van Soelen, Gerd Puehlhofer, F. Jankowsky, J. Veh, D. J. van der Walt, M. Fuessling, M. Lemoine-Goumard, M.A. Kastendieck, S. Bonnefoy, Axel Donath, A. W. Chen, I. Shilon, T. Tavernier, G. Emery, Matteo Cerruti, Michael Punch, M. Spir-Jacob, Manami Sasaki, S. Schwemmer, Andrea Santangelo, J. Lau, B. Peyaud, E. Leser, G. Hermann, Regis Terrier, Carlo Romoli, F. Gaté, R. Rauth, Fabian Schüssler, A. Jacholkowska, M. de Naurois, A. Woernlein, P. Bordas, D. A. Prokhorov, R. Marx, Werner Hofmann, Felix Spanier, Catherine Boisson, Stefan Funk, R. Zanin, R. C. G. Chaves, E. O. Angüner, D. Tiziani, I. Lypova, Stefan Wagner, Yasunobu Uchiyama, Christo Venter, D. Berge, D. Huber, D. Gottschall, P. T. O'Brien, Ullrich Schwanke, C. Perennes, Ruizhi Yang, S. Gabici, C. van Rensburg, J.F. Glicenstein, A. Marcowith, C. Hoischen, Wlodek Kluzniak, S. Saito, G. Fontaine, A. Zech, G. Maurin, K. Kosack, Jacek Niemiec, M. Lorentz, J. Becker Tjus, P.-O. Petrucci, L. Mohrmann, R. Steenkamp, A. Djannati-Ataï, S. Nakashima, Robert Wagner, J. Lefaucheur, A. Wierzcholska, Atreyee Sinha, C. van Eldik, C. Mariaud, A.M. Taylor, Aion Viana, S. Klepser, Olaf Reimer, R. J. White, G. Martí-Devesa, J.-P. Lenain, N. Shafi, Pierre Brun, T. Takahashi, Michael Backes, Gianluca Giavitto, T. Garrigoux, R. Blackwell, J. Hahn, N. Zywucka, Dieter Horns, I.D. Davids, S. Raab, Thomas Murach, E. Ruiz-Velasco, K. Egberts, Tim Holch, Reinhard Schlickeiser, M. Tsirou, G. Henri, A. M. W. Mitche, M. Mohamed, G. Vasileiadis, M. Ostrowski, H. Odaka, S. Chandra, P.J. Meintjes, S. Fegan, Marco Padovani, T. Lohse, A. Reimer, J. Bregeon, M. Renaud, H. Iwasaki, A. Carosi, R. R. Kruger, A. Lemière, H. Abdalla, B. Khélifi, Denys Malyshev, Nachiketa Chakraborty, K. Bernloehr, Stefan Ohm, S. Caroff, S. Pita, E. Moulin, Tomasz Bulik, D. Glawion, M. Panter, T. Bylund, Mohanraj Senniappan, A. Fiasson, L. Dirson, V. Poireau, L. Oakes, I. Sushch, A.A. Zdziarski, I. Jung-Richardt, Yvonne Becherini, D. Kerszberg, Masanori Arakawa, I. Oya, G. Heinzelmann, Felix Aharonian, L. Tibaldo, Zorawar Wadiasingh, B. Condon, Monica Barnard, F. Zefi, M. Buechele, M. Capasso, S. Krakau, V. Sahakian, D. Jankowsky, Q. Piel, J. Zorn, U. Katz, A.S. Seyffert, J.-P. Tavernet, P. Vincent, G. Lamanna, T. Vuillaume, P. deWilt, M. Seglar-Arroyo, J. King, B. Rudak, A. Priyana Noel, A. Dmytriiev, R. Moderski, V. Marandon, K. Katarzyński, L. Rinchiuso, L. Jouvin, M. Katsuragawa, C. Arcaro, M. Kraus, A. Specovius, Francois Brun, M. Tluczykont, Celine Armand, C. Steppa, M. Arrieta, Heike Prokoph, M. Haupt, Lukasz Stawarz, J. Dyks, K. Shiningayamwe, Andreas Quirrenbach, N. Tsuji, C. Trichard, J.-P. Ernenwein, R. D. Parsons, A. Ziegler, L. O. 'C. Drury, Ruben Lopez-Coto, M.-H. Grondin, P. Wagner, C. Dei, Y.A. Gallant, Gavin Rowell, M. Bryan, D. Zaborov, F. Niederwanger, Jacco Vink, Sabrina Casanova, H. J. Voelk, Frank M. Rieger, F. Voisin, J. Bolmont, S. Colafrancesco, Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Collège de France (CdF), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique (ex SAP) (DAP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), H.E.S.S., H.E.S.S. Collaboration, 26598973 - Abdalla, Hassan, 30588766 - Arcaro, Cornelia, 28644743 - Backes, Michael, 20574266 - Barnard, Monica, 24420530 - Böttcher, Markus, 31125417 - Chandra, Sunil, 26909995 - Garrigoux, Tania, 11749903 - Krüger, Petrus Paulus, 26403366 - Ndiyavala, Hambeleleni, 20126999 - Seyffert, Albertus Stefanus, 25161814 - Spanier, Felix Alexander, 24922986 - Sushch, Iurii, 10060499 - Van der Walt, Diederick Johannes, 21106266 - Van Rensburg, Carlo, 12006653 - Venter, Christo, 26594080 - Wadiasingh, Zorawar, 29092086 - Zacharias, Michael, Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Collège de France (CdF (institution)), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Faculty of Science, and High Energy Astrophys. & Astropart. Phys (API, FNWI)
Subjects: gamma-rays: galaxies, principal component analysis, Energy flux, Astrophysics, 01 natural sciences, pixel, HESS, ultraviolet, optical, energy: flux, HESS - Abteilung Hofmann, photon: flux, 010303 astronomy & astrophysics, model: leptonic, Physics, radio wave, density, active, [Galaxies], Gamma ray, galaxies [Gamma-rays], individual: 1ES 2322-409 [BL Lacertae objects], active [galaxies], infrared, Spectral energy distribution, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics::High Energy Astrophysical Phenomena, galaxies: active, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: energy spectrum, GLAST, blazar, X-ray, 0103 physical sciences, Blazar, Astroparticle physics, non-thermal [Radiation mechanisms], synchrotron radiation, background, 010308 nuclear & particles physics, Institut für Physik und Astronomie, Astronomy and Astrophysics, radiation mechanisms: non-thermal, redshift, proton synchrotron, MAGIC, Redshift, Crab Nebula, gamma ray: VHE, Space and Planetary Science, spectral, ddc:520, High Energy Physics::Experiment, BL Lacertae objects: individual: 1ES 2322−409, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract: 著者人数: H.E.S.S. Collaboration 233名 (所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 桂川, 美穂; 中島, 真也; 小高, 裕和; 高橋, 忠幸), Number of authors: H.E.S.S. Collaboration 233 (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Katsuragawa, Miho; Nakashima, Shinya; Odaka, Hirokazu; Takahashi, Tadayuki), Accepted: 2018-09-29, 資料番号: SA1180422000
Published: 2018

49. Arterial Stiffening with Ultrafast Ultrasound Imaging Gives New Insight into Arterial Phenotype of Vascular Ehlers- Danlos Mouse Models

Author: Xavier Jeunemaitre, Mickael Tanter, Clement Papadacci, Guillaume Goudot, Véronique Baudrie, Catherine Boisson-Vidal, Tristan Mirault, Blandine Dizier, Mathieu Pernot, Emmanuel Messas, Irmine Ferreira, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Thrombose : Épidémiologie, Physiopathologie et Thérapeutiques Innovantes (UMR_S 765), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Innovations thérapeutiques en hémostase (IThEM - U1140), Physique des ondes pour la médecine, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Therapie Cellulaire en Pathologie Cardio-Vasculaire (UMR_S 633), Risque Thrombotique et Mecanismes de l'Hemostase (U765), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), LABEX WIFI (Laboratory of Excellence ANR-10-LABX-24) within the French Program 'Investments for the Future' under reference ANR-10- IDEX-0001-02 PSL and a grant from Shire Human Genetic Therapies. We thank Mrs Beatrice Walker for her careful proofreading of the manuscript, Boisson-Vidal, Catherine, Sorbonne Université (SU)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, medicine.medical_specialty, MESH: collagen type III, MESH: mouse, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Blood Pressure, MESH: aorta, Pulse Wave Analysis, 030218 nuclear medicine & medical imaging, Mice, 03 medical and health sciences, Vascular Stiffness, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine.artery, medicine, Animals, Humans, MESH: pulse wave velocity, Radiology, Nuclear Medicine and imaging, Phenylephrine, Pulse wave velocity, Ultrasonography, Aorta, 030219 obstetrics & reproductive medicine, Cardiac cycle, business.industry, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, MESH: arterial stiffness, medicine.disease, Pulse pressure, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Phenotype, Blood pressure, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Hypertension, Cardiology, Arterial stiffness, cardiovascular system, Ehlers-Danlos Syndrome, Aortic stiffness, business, medicine.drug, circulatory and respiratory physiology
Abstract: Vascular Ehlers-Danlos syndrome (vEDS) is associated with arterial ruptures due to a mutant gene encoding collagen type III (Col-III). To better understand the role of Col-III, we aimed at evaluating aortic stiffness and dynamic stiffening in vEDS mouse models, with either a quantitative (col3KO mice) or a qualitative Col-III defect (col3KI mice). Abdominal aortic wall pulse wave velocities (PWV) in col3KO and col3KI mice were compared to their respective wild type (WT) littermates using a 15 MHz ultrafast ultrasonic transducer. A carotid catheter continuously monitored pressure changes due to phenylephrine injections. PWV1, generated at diastolic blood pressure (DBP), and PWV2, at systolic blood pressure (SBP) were recorded. Difference between PWV2 and PWV1 (Delta-PWV) normalized by the pulse pressure (PP), corresponding to the aortic stiffening over the cardiac cycle, were compared between mutant and WT mice, as well as the regression slope of PWV as a function of pressure. Delta-PWV/PP was lower in col3KO (p = 0.033) and col3KI mice (p 0.001) vs. WT-mice regardless of the pressure level. The slope of PWV1 with DBP increase showed a lower arterial stiffness in mutant mice vs. controls in both models. This difference was amplified when evaluating stiffness at systolic blood pressure levels with PWV2. In both vEDS mouse models, aortic stiffening was reduced, mainly driven by a lower stiffness at systolic blood pressure. Defective Col-III may be responsible for this, as it is utilized when pressure rises. These pre-clinical data could explain vascular fragility observed in vEDS patients.ZIEL: Das vaskuläre Ehlers-Danlos-Syndrom (vEDS) ist mit arteriellen Rupturen assoziiert, zurückzuführen auf ein mutiertes Gen, das für Kollagen Typ III (Col-III) kodiert. Um die Rolle von Col-III besser zu verstehen, untersuchten wir die Aortensteifigkeit und die dynamische Steifigkeit in vEDS-Mausmodellen, die entweder einen quantitativen (col3KO-Mäuse) oder einen qualitativen Col-III-Defekt (col3KI-Mäuse) hatten. Die Pulswellengeschwindigkeiten der Bauchaortenwand (PWV) in col3KO- und col3KI-Mäusen wurden mit denen ihrer jeweiligen Wildtyp (WT)- Wurfgeschwister mit einem 15 MHz Ultrafast-Ultraschall-Transducer verglichen. Ein Karotiskatheter überwachte fortlaufend die durch Injektion von Phenylephrin hervorgerufenen Druckänderungen. PWV1, erzeugt bei diastolischem Blutdruck (DBP) und PWV2, bei systolischem Blutdruck (SBP) wurden aufgezeichnet. Der Unterschied zwischen PWV2 und PWV1 (Delta-PWV), normalisiert durch den Pulsdruck (PP), welcher der Aortensteifigkeit beim Herzzyklus entspricht, sowie die Regressionsneigung von PWV als Funktion des Drucks wurde zwischen Mutanten- und WT-Mäusen verglichen. Delta-PWV/PP war unabhängig vom Druckniveau niedriger in col3KO- (p = 0,033) und col3KI-Mäusen (p 0,001) im Vergleich zu WT-Mäusen. Die Neigung von PWV1 bei DBP-Anstieg zeigte bei beiden Modellen eine geringere arterielle Steifigkeit in mutierten Mäusen im Vergleich zu den Kontrollen. Dieser Unterschied wurde verstärkt, wenn die Steifigkeit mit PWV2 bei systolischem Blutdruck bewertet wurde. Beide vEDS-Mausmodelle hatten eine reduzierte Aortensteifigkeit, hauptsächlich durch die geringere Steifigkeit beim systolischen Blutdruck. Das defekte Col-III Gen könnte dafür verantwortlich sein, da es zum Einsatz kommt, wenn der Druck steigt. Diese präklinischen Daten könnten die bei Patienten mit vEDS beobachtete vaskuläre Fragilität erklären.
Published: 2018

50. Lepto-hadronic single-zone models for the electromagnetic and neutrino emission of TXS 0506+056

Author: J.-P. Lenain, G. Emery, Catherine Boisson, Susumu Inoue, Alraune Zech, Matteo Cerruti, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Active galactic nucleus, electron: acceleration, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Proton Synchrotron, Cosmic ray, Astrophysics, Electron, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, GLAST, IceCube, jet: relativistic, neutrino: production, Astrophysical jet, Observatory, 0103 physical sciences, synchrotron, gamma rays: galaxies, AGN, BL Lacertae objects: individual: TXS 0506+056, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, photon, neutrinos, Astronomy and Astrophysics, radiation mechanisms: non-thermal, MAGIC, proton synchrotron, cascade, observatory, electromagnetic, gamma ray: VHE, 13. Climate action, Space and Planetary Science, cosmic radiation, High Energy Physics::Experiment, Neutrino, Compton scattering, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, BL Lac object
Abstract: While active galactic nuclei with relativistic jets have long been prime candidates for the origin of extragalactic cosmic rays and neutrinos, the BL Lac object TXS 0506+056 is the first astrophysical source observed to be associated with some confidence ($\sim 3\sigma$) with a high-energy neutrino, IceCube-170922A, detected by the IceCube Observatory. The source was found to be active in high-energy gamma-rays with Fermi-LAT and in very-high-energy gamma-rays with the MAGIC telescopes. To consistently explain the observed neutrino and multi-wavelength electromagnetic emission of TXS 0506+056, we investigate in detail single-zone models of lepto-hadronic emission, assuming co-spatial acceleration of electrons and protons in the jet, and synchrotron photons from the electrons as targets for photo-hadronic neutrino production. The parameter space concerning the physical conditions of the emission region and particle populations is extensively explored for scenarios where the gamma-rays are dominated by either 1) proton synchrotron emission or 2) synchrotron-self-Compton emission, with a subdominant but non-negligible contribution from photo-hadronic cascades in both cases. We find that the latter can be compatible with the neutrino observations, while the former is strongly disfavoured due to the insufficient neutrino production rate., Comment: In press in MNRAS; v2 to match the accepted version
Published: 2018

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