Search

Your search keyword '"Catherine B. Cetre-Sossah"' showing total 2 results
Start Over Author "Catherine B. Cetre-Sossah"
2 results on '"Catherine B. Cetre-Sossah"'

1. Risk Factors for Kala-Azar in Bangladesh

Author

Caryn Bern, Allen W. Hightower, Rajib Chowdhury, Mustakim Ali, Josef Amann, Yukiko Wagatsuma, Rashidul Haque, Katie Kurkjian, Louise E. Vaz, Moarrita Begum, Tangin Akter, Catherine B. Cetre-Sossah, Indu B. Ahluwalia, Ellen Dotson, W. Evan Secor, Robert F. Breiman, and James H. Maguire

Subjects
disease outbreaks, Epidemiology, leishmaniasis, risk factors, Visceral, prevention & control, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Since 1990, South Asia has experienced a resurgence of kala-azar (visceral leishmaniasis). To determine risk factors for kala-azar, we performed cross-sectional surveys over a 3-year period in a Bangladeshi community. By history, active case detection, and serologic screening, 155 of 2,356 residents had kala-azar with onset from 2000 to 2003. Risk was highest for persons 3–45 years of age, and no significant difference by sex was seen. In age-adjusted multivariable models, 3 factors were identified: proximity to a previous kala-azar patient (odds ratio [OR] 25.4, 95% confidence interval [CI] 15–44 within household; OR 3.2 95% CI 1.7–6.1 within 50 m), bed net use in summer (OR 0.7, 95% CI 0.53–0.93), and cattle per 1,000 m2 (OR 0.8, 95% CI 0.70–0.94]). No difference was seen by income, education, or occupation; land ownership or other assets; housing materials and condition; or keeping goats or chickens inside bedrooms. Our data confirm strong clustering and suggest that insecticide-treated nets could be effective in preventing kala-azar.

Published
2005
Full Text
View/download PDF

2. Higher percentages of circulating mast cell precursors correlate with susceptibility to reinfection with Schistosoma mansoni

Author

Lisa M, Ganley-Leal, Pauline N M, Mwinzi, Catherine B, Cetre-Sossah, Julius, Andove, Allen W, Hightower, Diana M S, Karanja, Daniel G, Colley, and W Evan, Secor

Subjects
Acquired Immunodeficiency Syndrome, Recurrence, Animals, Humans, Disease Susceptibility, Mast Cells, Schistosoma mansoni, Schistosomiasis mansoni, CD4 Lymphocyte Count
Abstract

A high level of serum IgE is generally associated with human resistance to schistosomes, though the protective mechanisms of IgE remain undefined. We recently reported that whereas some individuals who are occupationally hyperexposed to Schistosoma mansoni display resistance to reinfection, others remain highly susceptible, in some cases due to HIV-1 co-infection. As IgE functions, in part, through FcepsilonRI on mast cells, we characterized circulating CD117(+) FcepsilonRI(+) mast cell precursors in this population. Surprisingly, a higher percentage of CD117(+) cells correlated with a susceptible phenotype in HIV-1 seronegative participants with schistosomiasis. There was no association between percentages of peripheral CD117(+) cells and susceptibility to reinfection in persons with HIV-1. Serum levels of polyclonal IgE were inversely correlated with percentages of CD117(+) cells regardless of HIV-1 status. Thus, immature mast cells may affect IgE availability, or IgE may affect immature mast cells, altering the balance of host susceptibility and resistance to schistosomes.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results