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13 results on '"Catchpole, Timothy"'

7. Contact repulsion controls the dispersion and final distribution of Cajal-Retzius cells

Author

Ministerio de Ciencia e Innovación (España), National Institutes of Health (US), Consejo Superior de Investigaciones Científicas (España), Villar-Cerviño, Verona, Molano-Mazón, Manuel, Catchpole, Timothy, Valdeolmillos, Miguel, Henkemeyer, Mark, Martínez, Luis M., Borrell, Víctor, Marín Parra, Óscar, Ministerio de Ciencia e Innovación (España), National Institutes of Health (US), Consejo Superior de Investigaciones Científicas (España), Villar-Cerviño, Verona, Molano-Mazón, Manuel, Catchpole, Timothy, Valdeolmillos, Miguel, Henkemeyer, Mark, Martínez, Luis M., Borrell, Víctor, and Marín Parra, Óscar

Abstract

Cajal-Retzius (CR) cells play a fundamental role in the development of the mammalian cerebral cortex. They control the formation of cortical layers by regulating the migration of pyramidal cells through the release of Reelin. The function of CR cells critically depends on their regular distribution throughout the surface of the cortex, but little is known about the events controlling this phenomenon. Using time-lapse video microscopy in vivo and in vitro, we found that movement of CR cells is regulated by repulsive interactions, which leads to their random dispersion throughout the cortical surface. Mathematical modeling reveals that contact repulsion is both necessary and sufficient for this process, which demonstrates that complex neuronal assemblies may emerge during development through stochastic events. At the molecular level, we found that contact repulsion is mediated by Eph/ephrin interactions. Our observations reveal a mechanism that controls the even distribution of neurons in the developing brain.

Published
2013

9. Reelin induces EphB activation

Author

Bouché, Elisabeth, primary, Romero-Ortega, Mario I, additional, Henkemeyer, Mark, additional, Catchpole, Timothy, additional, Leemhuis, Jost, additional, Frotscher, Michael, additional, May, Petra, additional, Herz, Joachim, additional, and Bock, Hans H, additional

Published
2013
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12. Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression

Author

Genander, Maria, primary, Halford, Michael M., additional, Xu, Nan-Jie, additional, Eriksson, Malin, additional, Yu, Zuoren, additional, Qiu, Zhaozhu, additional, Martling, Anna, additional, Greicius, Gedas, additional, Thakar, Sonal, additional, Catchpole, Timothy, additional, Chumley, Michael J., additional, Zdunek, Sofia, additional, Wang, Chenguang, additional, Holm, Torbjörn, additional, Goff, Stephen P., additional, Pettersson, Sven, additional, Pestell, Richard G., additional, Henkemeyer, Mark, additional, and Frisén, Jonas, additional

Published
2009
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13. EphB Receptors Regulate Stem/Progenitor Cell Proliferation, Migration, and Polarity during Hippocampal Neurogenesis.

Author

Chumley, Michael J., Catchpole, Timothy, Silvany, Robert E., Kernie, Steven G., and Henkemeyer, Mark

Subjects
*CELL receptors, *CELL proliferation, *CELL migration, *CELL polarity, *STEM cells, *DEVELOPMENTAL neurobiology, *DENTATE gyrus, *HIPPOCAMPUS (Brain)
Abstract

The adult brain maintains two regions of neurogenesis from which new neurons are born, migrate to their appropriate location, and become incorporated into the circuitry of the CNS. One of these, the subgranular zone of the hippocampal dentate gyrus, is of primary interest because of the role of this region in learning and memory. We show that mice lacking EphB1, and more profoundly EphB1 and EphB2, have significantly fewer neural progenitors in the hippocampus. Furthermore, other aspects of neurogenesis, such as polarity, cell positioning, and proliferation are disrupted in animals lacking the EphB1 receptor or its cognate ephrin-B3 ligand. Our data strongly suggest that EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus and should be added to a short list of candidate target molecules for modulating the production and integration of new neurons as a treatment for neurodegenerative diseases or brain injury. [ABSTRACT FROM AUTHOR]

Published
2007
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