17 results on '"Catarina Lindqvist"'
Search Results
2. Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet – a randomised controlled trial
- Author
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Magnus Holmer, Catarina Lindqvist, Sven Petersson, John Moshtaghi-Svensson, Veronika Tillander, Torkel B. Brismar, Hannes Hagström, and Per Stål
- Subjects
Obesity ,Diet treatment ,Low-carb-high fat (LCHF) ,Intermittent calorie restriction ,5:2 diet ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction. Several diets have been proposed, with various effects specifically on liver steatosis. This trial compared the effects of intermittent calorie restriction (the 5:2 diet) and a low-carb high-fat diet (LCHF) on reduction of hepatic steatosis. Methods: We conducted an open-label randomised controlled trial that included 74 patients with NAFLD randomised in a 1:1:1 ratio to 12 weeks’ treatment with either a LCHF or 5:2 diet, or general lifestyle advice from a hepatologist (standard of care; SoC). The primary outcome was reduction of hepatic steatosis as measured by magnetic resonance spectroscopy. Secondary outcomes included transient elastography, insulin resistance, blood lipids, and anthropometrics. Results: The LCHF and 5:2 diets were both superior to SoC treatment in reducing steatosis (absolute reduction: LCHF: −7.2% [95% CI = −9.3 to −5.1], 5:2: −6.1% [95% CI = −8.1 to −4.2], SoC: −3.6% [95% CI = −5.8 to −1.5]) and body weight (LCHF: −7.3 kg [95% CI = −9.6 to −5.0]; 5:2: −7.4 kg [95% CI = −8.7 to −6.0]; SoC: −2.5 kg [95% CI =−3.5 to −1.5]. There was no difference between 5:2 and LCHF (p = 0.41 for steatosis and 0.78 for weight). Liver stiffness improved in the 5:2 and SoC but not in the LCHF group. The 5:2 diet was associated with reduced LDL levels and was tolerated to a higher degree than LCHF. Conclusions: The LCHF and 5:2 diets were more effective in reducing steatosis and body weight in patients with NAFLD than SoC, suggesting dietary advice can be tailored to meet individual preferences. Lay summary: For a person with obesity who suffers from fatty liver, weight loss through diet can be an effective treatment to improve the condition of the liver. Many popular diets that are recommended for weight reduction, such as high-fat diets and diets based on intermittent fasting, have not had their effects on the liver directly evaluated. This study shows that both a low-carb high-fat and the 5:2 diet are effective in treating fatty liver caused by obesity. Clinical Trials Registration: This study is registered at Clinicaltrials.gov (NCT03118310).
- Published
- 2021
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3. Complications of Gastrostomy Tubes in Patients With Head and Neck Cancer
- Author
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Miroslav Vujasinovic, Elin Marsk, Apostolos V. Tsolakis, Boel Hynning, Martin Nordberg, Mats Lindblad, Catarina Lindqvist, Lalle H. Nordenvall, Rusana Bark, and Peter Elbe
- Subjects
Gastrostomy ,Enteral Nutrition ,Otorhinolaryngology ,Head and Neck Neoplasms ,Malnutrition ,Humans ,Deglutition Disorders ,Intubation, Gastrointestinal ,Retrospective Studies - Abstract
Head and neck cancers (HNCs) include various malignant tumors of the upper aerodigestive tract. Due to their anatomical location, HNCs can cause obstruction, odynophagia, or trismus, leading to dysphagia. In addition, this patient group may be vulnerable to treatment side effects both by surgery and oncological treatment, exposing the patients to an even higher risk of malnutrition. The risk of malnourishment is often resolved by applying a feeding gastrostomy tube. The present study aims to identify complication rates after percutaneous endoscopic gastrostomy (PEG) and open gastrostomy (OG) in patients treated for HNC in a high-volume center.Retrospective cohort study.A retrospective cohort study of all patients treated for a new diagnosis of HNC at the Department of Otorhinolaryngology and Head and Neck Surgery at Karolinska University Hospital between January 1, 2000 and December 31, 2018 in whom gastrostomy was performed.Regarding tumor location, 165 (56.7%) were in the pharynx, 68 (23.4%) in the oral cavity, 57 (19.6%) in the larynx, and 1 (0.3%) in the nasal cavity. PEG was performed in 240 (82.5%) and OG in 51 (17.5%) patients. The overall complication rate was 28.2%: 64 (26.7%) among PEG patients and 18 (35.3%) among OG patients. The incidence of major complications was 3.1%.Our study confirms that enteral feeding via gastrostomy is a safe method, regardless of the technique used (PEG or OG), with a low rate of major complications and no mortality linked to the procedure.3 Laryngoscope, 132:1778-1784, 2022.
- Published
- 2022
4. Macronutrient composition and its effect on body composition changes during weight loss therapy in patients with non-alcoholic fatty liver disease: Secondary analysis of a randomized controlled trial
- Author
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Catarina Lindqvist, Magnus Holmer, Hannes Hagström, Sven Petersson, Veronika Tillander, Torkel B. Brismar, and Per Stål
- Subjects
Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism - Published
- 2023
5. Nutrition impact symptoms are related to malnutrition and quality of life – A cross-sectional study of patients with chronic liver disease
- Author
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Frode Slinde, Staffan Wahlin, Ammar Majeed, Catarina Lindqvist, and Matteo Bottai
- Subjects
Adult ,Male ,0301 basic medicine ,Abdominal pain ,medicine.medical_specialty ,Nausea ,Cross-sectional study ,medicine.medical_treatment ,Nutritional Status ,030209 endocrinology & metabolism ,Liver transplantation ,Critical Care and Intensive Care Medicine ,Chronic liver disease ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Predictive Value of Tests ,Weight loss ,Surveys and Questionnaires ,Internal medicine ,Prevalence ,medicine ,Humans ,health care economics and organizations ,Aged ,Sweden ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Liver Diseases ,Malnutrition ,Middle Aged ,medicine.disease ,Liver Transplantation ,Cross-Sectional Studies ,Nutrition Assessment ,Chronic Disease ,Quality of Life ,Female ,Symptom Assessment ,medicine.symptom ,business - Abstract
Patients with chronic liver disease often experience symptoms that affect their ability to eat. These symptoms can contribute to weight loss and malnutrition. We aimed to examine the prevalence of nutrition impact symptoms (NIS) in patients with chronic liver disease, and to investigate the relationships between NIS, malnutrition and health-related quality of life.In a cross-sectional study on adult patients with chronic liver disease under evaluation for liver transplantation, we studied NIS with two questionnaires: the Eating Symptoms Questionnaire and the Disease-Related Appetite Questionnaire. Malnutrition was primarily assessed with the Global Leadership Initiative on Malnutrition (GLIM) criteria. Health-related quality of life (HRQOL) was assessed with the Chronic Liver Disease Questionnaire.Among the 133 included patients, 90% reported one or more NIS and 51% reported four or more NIS. The most common symptoms were dry mouth (61%), abdominal pain (58%), diarrhoea (45%) and nausea (41%). Malnutrition was present in 32% according to GLIM criteria. Malnourished patients reported more NIS (p = 0.004) and had lower HRQOL (p 0.001). Certain NIS, such as pain, poor appetite, changes in taste and early satiety, were predictors for malnutrition.NIS are common in patients with chronic liver disease and are associated with malnutrition and worse HRQOL. NIS should therefore be systematically assessed in patients with chronic liver disease. Whether identification and proper management of NIS can prevent malnutrition and improve quality of life deserves further exploration.
- Published
- 2020
6. Protein intake early after liver transplantation and postoperative outcome: An observational study comparing two nutritional protocols
- Author
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Catarina Lindqvist, Peter Nordstedt, Mathias Vidgren, and Greg Nowak
- Subjects
Adult ,Male ,Observational Studies as Topic ,Nutrition and Dietetics ,Enteral Nutrition ,Postoperative Complications ,Nutritional Support ,Endocrinology, Diabetes and Metabolism ,Humans ,Female ,Postoperative Period ,Middle Aged ,Liver Transplantation - Abstract
Patients undergoing liver transplantation (LT) are at risk for eating difficulties. Adequate nutritional support is important to promote enhanced recovery and to reduce postoperative complications. The aim of this study was to evaluate two nutritional protocols and their effect on total protein intake during the first 7 d after LT.Adult patients were monitored daily for energy and protein intake during the first week after LT. Patients with ≥3 d of monitoring were included in the study. Two patient groups were studied: protocol A (pA) based on enteral nutrition (EN) provided from postoperative days 1 through 4 (historical control); and protocol B (pB), which was based on high volume of EN and high-protein oral nutritional supplements (ONS). Outcome measures were hospital length of stay and grade of complications according to Clavien-Dindo within the first 3 mo after transplantation.Seventy patients were included in the study (pA n=34, pB n= 36). The median age was 59 y and 70% were men. During postoperative week 1, patients with pB had a higher daily protein intake (95 g versus 77 g, P0.01) and met a higher proportion of estimated protein requirements (80% versus 70%, P0.05). There were no differences in severe postoperative outcomes between the two groups.A nutritional protocol with a higher rate of EN and high-protein ONS resulted in a higher protein intake early after LT. However, there was no difference in severe postoperative outcomes between the two nutritional protocols.
- Published
- 2021
7. Reply to: 'Reduced steatosis and weight as a result of specific diets or the dietitian themselves'
- Author
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Per Stål, Hannes Hagström, Magnus Holmer, and Catarina Lindqvist
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,RC799-869 ,Diseases of the digestive system. Gastroenterology ,medicine.disease ,Internal medicine ,Internal Medicine ,medicine ,Immunology and Allergy ,Steatosis ,business ,Letter to the Editor - Published
- 2021
8. Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet – a randomised controlled trial
- Author
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Torkel B. Brismar, Magnus Holmer, Veronika Tillander, Per Stål, Catarina Lindqvist, John Moshtaghi-Svensson, Sven Petersson, and Hannes Hagström
- Subjects
OGTT, oral glucose tolerance test ,Blood lipids ,RC799-869 ,Gastroenterology ,EoT, end of treatment ,NNR, Nordic Nutrition Recommendations 2012 ,Waist–hip ratio ,IR, insulin resistance ,WHR, waist-to-hip ratio ,Weight loss ,Intermittent fasting ,Immunology and Allergy ,Low-carb-high fat (LCHF) ,Fatty liver ,ITT, intention-to-treat analysis ,low-CHO, low-carbohydrate diet ,Diseases of the digestive system. Gastroenterology ,Diet treatment ,5:2 diet ,CT, computed tomography ,LCHF, low-carb high-fat diet ,Intermittent calorie restriction ,CAP, controlled attenuation parameter ,medicine.symptom ,Research Article ,ICR, intermittent calorie restriction ,NAFLD, non-alcoholic fatty liver disease ,medicine.medical_specialty ,HOMA-IR, homeostatic model assessment for insulin resistance ,NASH, non-alcoholic steatohepatitis ,PP, per protocol analysis ,E%, energy percent ,Insulin resistance ,ALT, alanine aminotransferase ,Internal medicine ,Internal Medicine ,medicine ,Obesity ,ALA, α-linolenic acid ,Hepatology ,SoC, standard of care ,business.industry ,PUFAs, polyunsaturated fatty acids ,MRS, magnetic resonance spectroscopy ,T2DM, type 2 diabetes mellitus ,medicine.disease ,SFAs, saturated fatty acids ,Steatosis ,MUFA, monounsaturated fatty acids ,Transient elastography ,business - Abstract
Background & Aims The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction. Several diets have been proposed, with various effects specifically on liver steatosis. This trial compared the effects of intermittent calorie restriction (the 5:2 diet) and a low-carb high-fat diet (LCHF) on reduction of hepatic steatosis. Methods We conducted an open-label randomised controlled trial that included 74 patients with NAFLD randomised in a 1:1:1 ratio to 12 weeks’ treatment with either a LCHF or 5:2 diet, or general lifestyle advice from a hepatologist (standard of care; SoC). The primary outcome was reduction of hepatic steatosis as measured by magnetic resonance spectroscopy. Secondary outcomes included transient elastography, insulin resistance, blood lipids, and anthropometrics. Results The LCHF and 5:2 diets were both superior to SoC treatment in reducing steatosis (absolute reduction: LCHF: −7.2% [95% CI = −9.3 to −5.1], 5:2: −6.1% [95% CI = −8.1 to −4.2], SoC: −3.6% [95% CI = −5.8 to −1.5]) and body weight (LCHF: −7.3 kg [95% CI = −9.6 to −5.0]; 5:2: −7.4 kg [95% CI = −8.7 to −6.0]; SoC: −2.5 kg [95% CI =−3.5 to −1.5]. There was no difference between 5:2 and LCHF (p = 0.41 for steatosis and 0.78 for weight). Liver stiffness improved in the 5:2 and SoC but not in the LCHF group. The 5:2 diet was associated with reduced LDL levels and was tolerated to a higher degree than LCHF. Conclusions The LCHF and 5:2 diets were more effective in reducing steatosis and body weight in patients with NAFLD than SoC, suggesting dietary advice can be tailored to meet individual preferences. Lay summary For a person with obesity who suffers from fatty liver, weight loss through diet can be an effective treatment to improve the condition of the liver. Many popular diets that are recommended for weight reduction, such as high-fat diets and diets based on intermittent fasting, have not had their effects on the liver directly evaluated. This study shows that both a low-carb high-fat and the 5:2 diet are effective in treating fatty liver caused by obesity. Clinical Trials Registration This study is registered at Clinicaltrials.gov (NCT03118310)., Graphical abstract, Highlights • Weight reduction is the only generally available treatment for NAFLD today. • High-fat diets, such as the LCHF, are controversial in treating NAFLD. • The 5:2 diet has become popular and is widely used to achieve weight loss. • In this RCT, both the LCHF and 5:2 diets were highly effective in treating NAFLD. • The 5:2 diet reduced LDL and liver stiffness and was tolerated to a higher degree.
- Published
- 2021
9. Assessment of muscle mass depletion in chronic liver disease: Dual-energy x-ray absorptiometry compared with computed tomography
- Author
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Staffan Wahlin, Torkel B. Brismar, Catarina Lindqvist, and Ammar Majeed
- Subjects
Adult ,Male ,0301 basic medicine ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Liver transplantation ,Chronic liver disease ,Body Mass Index ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Lumbar ,Ascites ,medicine ,Humans ,Mass index ,Muscle, Skeletal ,Dual-energy X-ray absorptiometry ,Aged ,Retrospective Studies ,Lumbar Vertebrae ,030109 nutrition & dietetics ,Nutrition and Dietetics ,medicine.diagnostic_test ,business.industry ,Liver Diseases ,Reproducibility of Results ,Skeletal muscle ,Middle Aged ,medicine.disease ,Liver Transplantation ,Muscular Atrophy ,medicine.anatomical_structure ,Sarcopenia ,Chronic Disease ,Preoperative Period ,Body Composition ,Female ,medicine.symptom ,Tomography, X-Ray Computed ,Nuclear medicine ,business - Abstract
Objectives The aim of this study was to perform intermethod comparisons between the following three measures of muscle mass depletion in patients eligible for liver transplantation: 1) fat-free mass index (FFMI) measured by dual-energy x-ray absorptiometry (DXA), 2) appendicular skeletal muscle mass index (ASMI) measured by DXA, and 3) skeletal muscle index (SMI) measured at the third lumbar level by computed tomography (CT). Methods The medical records of patients who received liver transplants between 2009 and 2012 at Karolinska University Hospital were retrospectively reviewed. Adult patients with a chronic liver disease who had both DXA and CT scans performed within a 30-d period during their pretransplant workup were included. Results Appendicular skeletal muscle mass index measured by DXA (ASMIDXA) and skeletal mass index measured by computed tomography (SMICT) provide similar results when assessing the presence of muscle mass depletion in patients with chronic liver diseases and FFMIDXA can be falsely high in patients with ascites. Both ASMIDXA and SMICT thus appear to be useful methods in the pretransplant evaluation of muscle mass depletion both for patients with and without ascites. Conclusions ASMI measured with DXA is a useful alternative method to SMI measured with CT when a CT scan is not clinically indicated or available.
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- 2019
10. Body composition evaluation with computed tomography: Contrast media and slice thickness cause methodological errors
- Author
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Lena Martin, Torkel B. Brismar, Catarina Lindqvist, Yi-Hua Zhang, Fabian Morsbach, University of Zurich, and Morsbach, Fabian
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Adult ,Male ,0301 basic medicine ,Carcinoma, Hepatocellular ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Slice thickness ,Contrast Media ,Adipose tissue ,610 Medicine & health ,030209 endocrinology & metabolism ,Computed tomography ,Radiation Dosage ,03 medical and health sciences ,Muscle attenuation ,0302 clinical medicine ,Humans ,Medicine ,Contrast (vision) ,Diagnostic Errors ,Muscle, Skeletal ,Aged ,Retrospective Studies ,media_common ,Aged, 80 and over ,030109 nutrition & dietetics ,Nutrition and Dietetics ,medicine.diagnostic_test ,10042 Clinic for Diagnostic and Interventional Radiology ,business.industry ,Attenuation ,Liver Neoplasms ,Skeletal muscle ,Middle Aged ,2712 Endocrinology, Diabetes and Metabolism ,medicine.anatomical_structure ,Adipose Tissue ,Body Composition ,2916 Nutrition and Dietetics ,Female ,Tomography, X-Ray Computed ,business ,Nuclear medicine ,Perfusion - Abstract
Although computed tomography (CT) is frequently used to determine body composition, the effects of using different CT protocols is not well known. The aim of this study was to determine whether contrast media phase, radiation dose, and slice thickness in CT affect body composition segmentation.Clinically indicated perfusion CTs of the upper abdomen in 20 patients (seven women) between 40 and 87 y of age with high suspicion of hepatocellular carcinoma were analyzed retrospectively. Axial images from the L3 level with varying imaging delay were reconstructed after contrast media injection (18 images per patient), slice thickness (5 images, 2-10 mm), and radiation dose (4 images with one-third to four-thirds of standard dose). Muscle and fat areas were segmented semiautomatically by drawing regions of interests and using established cutoff thresholds. Skeletal muscle index (SMI), steatotic muscle area, and adipose tissue index, as well as muscle attenuation and fat attenuation, were evaluated.Average SMI increased by up to 2.8% after contrast media injection. Steatotic muscle area decreased by ≤13.8%, and adipose tissue index decreased by ≤6.5%. Muscle attenuation increased after contrast media injection, whereas fat attenuation decreased (all P0.001). SMI decreased by 1.9% on average when increasing slice thickness from 2 to 10 mm. Steatotic muscle area increased by ≤3.3%, and adipose tissue index increased by ≤1.5% (all P0.05). Muscle attenuation did not change significantly with reconstruction thickness. Radiation dose had no effect on estimated area of spinal muscle, fatty spinal muscle, or visceral fat.Contrast media have a strong effect on the evaluation of body composition, whereas the influence of slice thickness is less pronounced. Radiation dose can be reduced by ≥66% without significantly affecting segmentation.
- Published
- 2019
11. Influence of tube potential on CT body composition analysis
- Author
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Torkel B. Brismar, Catarina Lindqvist, Anders Svensson, Patrik Nowik, Fabian Morsbach, Lena Martin, Yi-Hua Zhang, University of Zurich, and Morsbach, Fabian
- Subjects
Adult ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Contrast Media ,610 Medicine & health ,Computed tomography ,Composition analysis ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Hounsfield scale ,Humans ,Medicine ,Tube (container) ,Muscle, Skeletal ,Aged ,Retrospective Studies ,Aged, 80 and over ,Intravenous contrast ,Nutrition and Dietetics ,medicine.diagnostic_test ,10042 Clinic for Diagnostic and Interventional Radiology ,business.industry ,Reproducibility of Results ,Skeletal muscle ,Middle Aged ,Radiographic Image Enhancement ,2712 Endocrinology, Diabetes and Metabolism ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Body Composition ,2916 Nutrition and Dietetics ,Abdomen ,Female ,Tomography, X-Ray Computed ,business ,Nuclear medicine ,Body mass index - Abstract
Objectives Our purpose was to investigate whether tube potential in contrast-enhanced computed tomography (CT) affects body composition analysis. Methods Images from dual-source, dual-energy CT from the abdomen with intravenous contrast media administration were used. A total of 17 patients (11 women, mean age 52) with a mean body mass index of 20.8 kg/cm2 were included. Simultaneously acquired images with a tube voltage of 80 kV and 140 kV were compared. Body composition was analyzed on a single slice at the L3 level. Parameters evaluated included muscle and fat attenuation (Hounsfield units [HU]), skeletal muscle index (cm2/m2), muscle area (cm2), and steatotic muscle area (cm2). Significant differences between 80 kV and 140 kV series were compared using the paired Student's t test. Results Tube potential affected muscle attenuation with an average difference of 17% between 80 kV and 140 kV series (48 HU versus 41 HU, P Conclusion Tube potential significantly affects body segmentation in contrast-enhanced CT.
- Published
- 2018
12. Energy expenditure early after liver transplantation: Better measured than predicted
- Author
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Staffan Wahlin, Peter Nordstedt, Ammar Majeed, Greg Nowak, Frode Slinde, Matteo Bottai, and Catarina Lindqvist
- Subjects
0301 basic medicine ,Multivariate statistics ,Endocrinology, Diabetes and Metabolism ,Concordance ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Calorimetry ,Liver transplantation ,Severity of Illness Index ,End Stage Liver Disease ,03 medical and health sciences ,0302 clinical medicine ,Animal science ,Interquartile range ,Humans ,Medicine ,Resting energy expenditure ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Calorimetry, Indirect ,Confidence interval ,Liver Transplantation ,Concordance correlation coefficient ,Basal Metabolism ,Energy Metabolism ,business - Abstract
Objective There is no consensus on how to estimate energy requirements after liver transplantation (LT). The aim of this study was to compare measured resting energy expenditure (REE) with predictive equations and fixed factors, and evaluate whether clinical variables were associated with REE. Methods During the period of 2011 through 2018, REE measured with indirect calorimetry and predicted by the Harris and Benedict (HB) equation was compared in patients during the first 30 postoperative days after LT. The fixed factors 25 kcal/kg, 30 kcal/kg, or 35 kcal/kg were used to calculate energy requirements. The accuracy of HB and fixed factors were evaluated with a Bland-Altman analysis and Lin’s concordance correlation coefficient. The associations of pre- and postoperative clinical variables with REE were evaluated in a multivariate regression analysis. Results A total of 143 patients were evaluated and had indirect calorimetry performed on postoperative day 6 (interquartile range: 3) in median. The mean measured REE was 1950 ± 461 kcal (range, 720–3309 kcal) or 24.5 ± 6.1 kcal/kg body weight. Large limits of agreements were observed in the Bland-Altman analyses for both HB and fixed factors. HB was closer than fixed factors with a positive concordance (concordance correlation: 0.350; 95% confidence interval, 0.248–0.445) and Pearsons r2 = 0.261. Measured REE was significantly associated (P Conclusions The low accuracy of HB and fixed factors suggests risks of both under- and overfeeding of individual patients if energy requirement is only based on calculation. REE measurement is recommended after LT to secure accurate and safe nutritional therapy.
- Published
- 2020
13. Nutrition impact symptoms affects quality of life and nutritional status in patients with chronic liver disease
- Author
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Frode Slinde, Catarina Lindqvist, Staffan Wahlin, and Ammar Majeed
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,Quality of life (healthcare) ,business.industry ,Medicine ,In patient ,Nutritional status ,Critical Care and Intensive Care Medicine ,business ,Intensive care medicine ,Chronic liver disease ,medicine.disease - Published
- 2018
14. MON-PO510: Energy and Protein Intake After Liver Transplantation – A Comparison of Two Nutritional Protocols
- Author
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P. Nordstedt, Catarina Lindqvist, and G. Nowak
- Subjects
Nutrition and Dietetics ,business.industry ,medicine.medical_treatment ,medicine ,Physiology ,Liver transplantation ,Critical Care and Intensive Care Medicine ,Protein intake ,business - Published
- 2019
15. Body composition assessed by dual-energy X-ray absorptiometry predicts early infectious complications after liver transplantation
- Author
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Catarina Lindqvist, Ammar Majeed, and Staffan Wahlin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cirrhosis ,Endpoint Determination ,medicine.medical_treatment ,Medicine (miscellaneous) ,Nutritional Status ,Liver transplantation ,Communicable Diseases ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Absorptiometry, Photon ,Postoperative Complications ,law ,Risk Factors ,Internal medicine ,medicine ,Prevalence ,Humans ,Mass index ,030212 general & internal medicine ,Risk factor ,Dual-energy X-ray absorptiometry ,Dialysis ,Aged ,Retrospective Studies ,Nutrition and Dietetics ,medicine.diagnostic_test ,business.industry ,Malnutrition ,Retrospective cohort study ,Length of Stay ,Middle Aged ,medicine.disease ,Intensive care unit ,Surgery ,Liver Transplantation ,Logistic Models ,Nutrition Assessment ,Body Composition ,030211 gastroenterology & hepatology ,Female ,business - Abstract
Background It is challenging to identify malnutrition, which is a risk factor for poor outcome in patients with liver cirrhosis. In the present study, we aimed to investigate the prevalence of malnutrition among patients listed for liver transplantation, as assessed by different methods, and also to relate dual-energy X-ray absorptiometry (DXA) to short-term post-transplant outcomes. Methods In this retrospective cohort study, we reviewed the medical records of 106 patients who underwent liver transplantation in 2009–2012. Body composition was assessed by the fat-free mass index (FFMI) and fat mass index (FMI) obtained using DXA. Severe infections within 1 month, length of stay in intensive care unit and length of hospital stay were endpoints of primary interest. Results The prevalence of malnutrition was 2–20% depending on sex and the assessment method. Thirty-nine (37%) patients developed severe infections within 1 month after liver transplantation. In multivariate analysis with logistic regression, body composition was significantly associated with post-operative infection when measured with FFMI (P = 0.043) but not with FMI (P = 0.087). Post-operative dialysis (P = 0.004) and post-operative infections (P < 0.001) were significantly associated with length of stay in hospital. Post-operative bleeding (P = 0.015), duration of mechanical ventilation (P < 0.001) and the need for dialysis (P < 0.001), but not body composition, were significant predictors of the length of stay in the intensive care unit. Conclusions The prevalence of malnutrition depends on assessment method. FFMI is an independent predictor for early post-transplant infections. Body composition measured by DXA during the pretransplant evaluation provides valuable information about nutritional status in patients with liver cirrhosis.
- Published
- 2016
16. MON-LB320: Indirect Calorimetry After Liver Transplantation is Needed to Ensure the Rightamount of Energy Supplied
- Author
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G. Nowak, Catarina Lindqvist, and P. Nordstedt
- Subjects
Nutrition and Dietetics ,business.industry ,medicine.medical_treatment ,Radiochemistry ,medicine ,Calorimetry ,Liver transplantation ,Critical Care and Intensive Care Medicine ,business - Published
- 2017
17. MON-PP044: Nutrition Impact Symptoms in Patients Listed for Liver Transplantation
- Author
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Staffan Wahlin, Ammar Majeed, and Catarina Lindqvist
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,medicine.medical_treatment ,Internal medicine ,medicine ,In patient ,Liver transplantation ,Critical Care and Intensive Care Medicine ,business ,Gastroenterology - Published
- 2015
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