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12 results on '"Catanoso, Marialuigia"'

1. SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

Author

Rosichini, Marco, Bordoni, Veronica, Silvestris, Domenico Alessandro, Mariotti, Davide, Matusali, Giulia, Cardinale, Antonella, Zambruno, Giovanna, Condorelli, Angelo Giuseppe, Flamini, Sara, Genah, Shirley, Catanoso, Marialuigia, Del Nonno, Franca, Trezzi, Matteo, Galletti, Lorenzo, De Stefanis, Cristiano, Cicolani, Nicolò, Petrini, Stefania, Quintarelli, Concetta, Agrati, Chiara, Locatelli, Franco, and Velardi, Enrico

Published
2023
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2. Mucosal-Associated Invariant T (MAIT) Cells Are Functionally Impaired in Pediatric Patients Following HCT and Their Recovery Is Associated with the Onset of GvHD

Author

Velardi, Enrico, primary, Flamini, Sara, additional, Galaverna, Federica, additional, Boccieri, Emilia, additional, Dolores De Luca, Carmen, additional, Benini, Francesca, additional, Quagliarella, Francesco, additional, Rosichini, Marco, additional, Catanoso, Marialuigia, additional, Cardinale, Antonella, additional, Velardi, Shirley, additional, Volpe, Gabriele, additional, Pitisci, Angela, additional, Coccetti, Marianna, additional, Carta, Roberto, additional, Del Bufalo, Francesca, additional, Bertaina, Valentina, additional, Becilli, Marco, additional, Pagliara, Daria, additional, Algeri, Mattia, additional, Merli, Pietro, additional, and Locatelli, Franco, additional

Published
2022
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3. Updated Analysis on the Outcomes of Children with Acute Leukemia (AL) Receiving an Alpha/Beta T and B-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (TBdepl-haploHSCT)

Author

Merli, Pietro, primary, Algeri, Mattia, additional, Galaverna, Federica, additional, Quagliarella, Francesco, additional, Bertaina, Valentina, additional, Girolami, Elia, additional, Meschini, Antonella, additional, Del Principe, Giovanna, additional, Biagini, Simone, additional, Sborgia, Raffaella, additional, Lucarelli, Barbarella, additional, Pagliara, Daria, additional, Catanoso, Marialuigia, additional, Rosignoli, Chiara, additional, Cossutta, Matilde, additional, Lanzaro, Francesca, additional, Canino, Costanza, additional, Cefalo, Maria Giuseppina, additional, Strocchio, Luisa, additional, Boccieri, Emilia, additional, Becilli, Marco, additional, Carta, Roberto, additional, Del Bufalo, Francesca, additional, Li Pira, Giuseppina, additional, and Locatelli, Franco, additional

Published
2022
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6. Outcome of Children with Wiskott-Aldrich Syndrome (WAS) Given TCR Alpha-Beta/CD19 Depleted Hematopoietic Stem Cell Transplantation (HSCT) from an HLA-Haploidentical Relative

Author

Algeri, Mattia, primary, Pagliara, Daria, additional, Bertaina, Valentina, additional, Li Pira, Giuseppina, additional, Girolami, Elia, additional, Leone, Giovanna, additional, Meschini, Antonella, additional, Boccieri, Emilia, additional, Galaverna, Federica, additional, Catanoso, Marialuigia, additional, Del Bufalo, Francesca, additional, Merli, Pietro, additional, and Locatelli, Franco, additional

Published
2021
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7. MS-275 (Entinostat) Promotes Radio-Sensitivity in PAX3-FOXO1 Rhabdomyosarcoma Cells

Author

Cassandri, Matteo, primary, Pomella, Silvia, additional, Rossetti, Alessandra, additional, Petragnano, Francesco, additional, Milazzo, Luisa, additional, Vulcano, Francesca, additional, Camero, Simona, additional, Codenotti, Silvia, additional, Cicchetti, Francesca, additional, Maggio, Roberto, additional, Festuccia, Claudio, additional, Gravina, Giovanni Luca, additional, Fanzani, Alessandro, additional, Megiorni, Francesca, additional, Catanoso, Marialuigia, additional, Marchese, Cinzia, additional, Tombolini, Vincenzo, additional, Locatelli, Franco, additional, Rota, Rossella, additional, and Marampon, Francesco, additional

Published
2021
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8. Improved T- and B-Cell Neogenesis in Children with Acute Leukemia Given an Alpha-Beta T-Cell Depleted Haplo-HSCT Combined with the Infusion of Donor T-Cells Genetically Modified with Inducible Caspase 9 Suicide Gene (Rivo-cel)

Author

Catanoso, Marialuigia, Algeri, Mattia, Velardi, Enrico, Clave, Emmanuel, Toubert, Antoine, Del Bufalo, Francesca, Merli, Pietro, Pagliara, Daria, Lucarelli, Barbarella, Galaverna, Federica, Rosichini, Marco, Bertaina, Valentina, Li Pira, Giuseppina, Surace, Cecilia, Boccieri, Emilia, Carta, Roberto, Becilli, Marco, Quagliarella, Francesco, and Locatelli, Franco

Published
2023
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9. Reconstitution Dynamics and Impact on Clinical Outcomes of Mucosal-Associated Invariant T-Cells in Pediatric Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

Author

Galaverna, Federic, Flamini, Sara, Pili, Ilaria, De Luca, Carmen, Boccieri, Emilia, Benini, Francesca, Quagliarella, Francesco, Rosichini, Marco, Catanoso, Marialuigia, Coccetti, Marianna, Genah, Shirley, Carta, Roberto, Del Bufalo, Francesca, Bertaina, Valentina, Becilli, Marco, Pagliara, Daria, Algeri, Mattia, Merli, Pietro, Locatelli, Franco, and Velardi, Enrico

Published
2023
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10. Eltrombopag in paediatric immune thrombocytopenia: Iron metabolism modulation in mesenchymal stromal cells.

Author

Di Paola, Alessandra, Palumbo, Giuseppe, Tortora, Chiara, Argenziano, Maura, Catanoso, Marialuigia, Di Leva, Caterina, Ceglie, Giulia, Perrotta, Silverio, Locatelli, Franco, and Rossi, Francesca

Subjects
IDIOPATHIC thrombocytopenic purpura, IRON metabolism, STROMAL cells, REGULATORY B cells, THROMBOPOIETIN receptor agonists
Abstract

Summary: Immune thrombocytopenia (ITP) is an autoimmune disease caused by platelet destruction mediated by auto‐antibody production. It is characterized by a compromised immune system and alteration of the inflammatory response. Mesenchymal stromal cells (MSCs) play an important role in modulating immune and inflammatory processes, exerting immune‐suppressing and anti‐inflammatory properties. In ITP‐MSCs the activity and survival are strongly impaired. Eltrombopag (ELT) is a thrombopoietin receptor agonist approved in chronic ITP for stimulating platelet production. It has immunomodulating properties by stimulating T and B regulatory cell activity and by promoting a macrophage switch from the pro‐inflammatory to the anti‐inflammatory phenotype. ELT also exhibits iron‐chelating properties. Iron is a crucial element involved in several physiologic processes, but its intracellular accumulation determines cell damages. Therefore, for the first time we analysed the effect of ELT on ITP‐MSCs demonstrating its ability to restore survival and activity of MSCs directly and to promote their survival and proliferation indirectly, by iron metabolism modulation. [ABSTRACT FROM AUTHOR]

Published
2022
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11. T- and B-Cell Neogenesis Recovers Efficiently in Children with Acute Leukemia Given an Alpha-Beta T-Cell Depleted Haplo-HSCT Followed By Infusion of Donor T-Cells Genetically Modified with Inducible Caspase 9 Suicide Gene (BPX-501 cells)

Author

Catanoso, Marialuigia, primary, Clave, Emmanuel, additional, Douay, Corinne, additional, Algeri, Mattia, additional, Fournier, Isabelle, additional, Bertaina, Valentina, additional, Araujo, Itaua Leston, additional, Del Bufalo, Francesca, additional, Galaverna, Federica, additional, Surace, Cecilia, additional, Bertaina, Alice, additional, Merli, Pietro, additional, Foster, Aaron, additional, Toubert, Antoine, additional, and Locatelli, Franco, additional

Published
2018
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12. Mucosal-associated invariant T cells are functionally impaired in pediatric and young adult patients following allogeneic hematopoietic stem cell transplantation and their recovery correlates with clinical outcomes.

Author

Galaverna F, Flamini S, De Luca CD, Pili I, Boccieri E, Benini F, Quagliarella F, Rosignoli C, Rosichini M, Genah S, Catanoso M, Cardinale A, Volpe G, Coccetti M, Pitisci A, Li Pira G, Carta R, Lucarelli B, Del Bufalo F, Bertaina V, Becilli M, Pagliara D, Algeri M, Merli P, Locatelli F, and Velardi E

Subjects
Humans, Child, Adolescent, Male, Female, Young Adult, Child, Preschool, Adult, Retrospective Studies, Hematologic Neoplasms therapy, Hematologic Neoplasms immunology, Hematologic Neoplasms mortality, Infant, Treatment Outcome, Transplantation Conditioning, Hematopoietic Stem Cell Transplantation adverse effects, Hematopoietic Stem Cell Transplantation methods, Mucosal-Associated Invariant T Cells immunology, Graft vs Host Disease etiology, Graft vs Host Disease immunology, Transplantation, Homologous
Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like T cells implicated in the response to fungal and bacterial infections. Their contribution to restoring T-cell immunity and influencing hematopoietic stem cell transplant (HSCT) outcomes remains poorly understood. We retrospectively studied MAIT-cell recovery in 145 consecutive children and young adults with hematologic malignancies undergoing allogeneic (allo)-HSCT between April 2019 and May 2022, from unrelated matched donor (MUD, N=52), with standard graft-versus-host-disease (GvHD) prophylaxis, or HLA-haploidentical (Haplo, N=93) donor after in vitro αβT/CD19-cell depletion, without post-HSCT pharmacological prophylaxis. With a median follow-up of 33 months (range, 12-49 months), overall survival (OS), disease-free survival (DFS), and non-relapse mortality (NRM) were 79.5%, 72%, and 7%, respectively; GvHD-free relapse-free survival (GRFS) was 63%, while cumulative incidence of relapse was 23%. While αβT cells were reconstituted 1-2 years post HSCT, MAIT cells showed delayed recovery and prolonged functional impairment, characterized by expression of activation (CD25, CD38), exhaustion (PD1, TIM3) and senescence (CD57) markers, and suboptimal ex vivo response. OS, DFS, and NRM were not affected by MAIT cells. Interestingly, higher MAIT cells at day +30 correlated with higher incidence of grade II-IV acute GvHD (19% vs. 7%, P=0.06). Furthermore, a greater MAIT-cell count tended to be associated with a higher incidence of chronic GvHD (cGvHD) (17% vs. 6%, P=0.07) resulting in lower GRFS (55% vs. 73%, P=0.05). Higher MAIT cells also correlated with greater cytomegalovirus (CMV) reactivation and lower late blood stream infections (BSI) (44% vs. 24%, P=0.02 and 9% vs. 18%, P=0.08, respectively). Future studies are needed to confirm the impact of early MAIT-cell recovery on cGvHD, CMV reactivation, and late BSI.

Published
2024
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