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1. Cancer diagnosis and suicide outcomes: prevalence and risk meta-analysis

Author

Peviani, G, Casu, D, Mansi, W, De Prisco, M, Madeddu, F, López-Castroman, J, Fornaro, M, Calati, R, Peviani G, Casu D, Mansi W, De Prisco M, Madeddu F, López-Castroman J, Fornaro M, Calati R, Peviani, G, Casu, D, Mansi, W, De Prisco, M, Madeddu, F, López-Castroman, J, Fornaro, M, Calati, R, Peviani G, Casu D, Mansi W, De Prisco M, Madeddu F, López-Castroman J, Fornaro M, and Calati R

Published
2022

2. Cancer diagnosis and suicide outcomes: Umbrella review and methodological considerations

Author

Calati, R, Filipponi, C, Mansi, W, Casu, D, Peviani, G, Gentile, G, Tambuzzi, S, Zoja, R, Fornaro, M, Lopez-Castroman, J, Madeddu, F, Calati R., Filipponi C., Mansi W., Casu D., Peviani G., Gentile G., Tambuzzi S., Zoja R., Fornaro M., Lopez-Castroman J., Madeddu F., Calati, R, Filipponi, C, Mansi, W, Casu, D, Peviani, G, Gentile, G, Tambuzzi, S, Zoja, R, Fornaro, M, Lopez-Castroman, J, Madeddu, F, Calati R., Filipponi C., Mansi W., Casu D., Peviani G., Gentile G., Tambuzzi S., Zoja R., Fornaro M., Lopez-Castroman J., and Madeddu F.

Abstract

Background: Suicide outcomes in cancer patients represent a major public health concern. We performed an umbrella review (UR) including all meta-analyses (MAs) and systematic reviews (SRs) published on the association between cancer and suicide outcomes. Methods: Eligible studies were searched in the main scientific databases up to January 23rd, 2021. Eligible MAs/SRs focused on all suicide phenotypes among cancer patients. Evidence of the association was extracted; the credibility and quality of the included studies were evaluated using ad-hoc tools, including “A MeaSurement Tool to Assess systematic Reviews-2-Revised” (AMSTAR-2-R). Results: Six MAs and 6 SRs were included. The standardized mortality ratio of suicide in cancer patients was 1.5 to 1.7-fold higher than in the general population. Risk factors for suicide outcomes among cancer patients were male sex and older age, a cancer diagnosis within the prior year, and some specific cancer sites. Among 107 associations, 90 (84.1%) were supported by high credibility of evidence (class II). However, all studies reported a large heterogeneity (I2> 50%) and the majority of them reported considerable heterogeneity (I2> 75%). All MAs used random-effects measures. All MAs but one assessed publication bias and only one disclosed it. The majority of MAs/SRs showed critically low quality based on AMSTAR-2-R. Limitations: We could not perform additional analyses due to the limited number of MAs. Conclusions: This UR underlines the inflated risk for suicide among cancer patients. Upcoming, well-designed studies are needed to account for a broader set of variables. Several methodological issues likewise warrant attention.

Published
2021

3. Cancer diagnosis and suicide outcomes: prevalence and risk meta-analysis

Author

Peviani G, Casu D, Mansi W, De Prisco M, Madeddu F, López-Castroman J, Fornaro M, Calati R, Peviani, G, Casu, D, Mansi, W, De Prisco, M, Madeddu, F, López-Castroman, J, Fornaro, M, and Calati, R

Subjects
Psychiatry and Mental health, Cancer, suicide, meta-analysis
Abstract

Introduction Available meta-analytic evidence suggests an increased risk of suicide among cancer patients, although most of the reports focused on the sole suicide death (SD) outcome and they are usually hampered by significant between-study heterogeneity. Objectives The present meta-analysis aimed at assessing the prevalence and risk rates of SD, suicide attempt (SA), and suicidal ideation (SI) among cancer patients. Methods Systematic search up to April 2021 of observational studies documenting cancer and suicide outcomes associations. Pooled prevalence estimates, odd ratios (ORs), risk ratios (RRs), and hazard ratios (HRs) of SD, SA, and SI were computed according to the random-effects model. SD prevalence underwent cumulative and sub-group analyses for different variables. Risk estimates underwent sensitivity analysis for study design. Results Overall, thirty-nine studies were included. A higher risk of SD based on HR, SA based on OR and HR, and SI based on each measure was recorded among cancer patients versus controls. OR and RR of SD were not significant. Pooled prevalence rates of SD, SA and SI among cancer patients were 1.9% (1.1-3.1%), 1.4% (0.3-7.1%), and 9.1% (5.8-14.0%), respectively. Although high between-study heterogeneity held upon sensitivity and sub-group analyses, the overall message brought by risk analyses likewise held true. Age, country, study design, cancer type, sample size, cases type and comparison affected SD prevalence estimates in cancer patients. SD prevalence decreased over time. Conclusions Cancer patients face higher risk for SA and SI versus controls. SD’ results were controversial. Cancer patients have higher prevalence rates of suicide outcomes compared to the general population. Disclosure No significant relationships.

Published
2022
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8. Mutations in DSTYK and Dominant Urinary Tract Malformations

Author

Sanna-Cherchi, S., Sampogna, R. V., Papeta, N., Burgess, K. E., Nees, S. N., Perry, B. J., Choi, M., Bodria, M., Liu, Y., Weng, P. L., Lozanovski, V. J., Verbitsky, M., Lugani, F., Sterken, R., Paragas, N., Caridi, G., Carrea, A., Dagnino, M., Materna-Kiryluk, A., Santamaria, G., Murtas, C., Ristoska-Bojkovska, N., Izzi, C., Kacak, N., Bianco, B., Giberti, S., Gigante, M., Piaggio, G., Gesualdo, L., Kosuljandic Vukic, D., Vukojevic, K., Saraga-Babic, M., Saraga, M., Gucev, Z., Allegri, L., Latos-Bielenska, A., Casu, D., State, M., Scolari, F., Ravazzolo, R., Kiryluk, K., Al-Awqati, Q., DʼAgati, V. D., Drummond, I. A., Tasic, V., Lifton, R. P., Ghiggeri, G. M., and Gharavi, A. G.

Published
2013
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11. Mutations in DSTYK and dominant urinary tract malformations

Author

Sanna Cherchi, S, Sampogna, Rv, Papeta, N, Burgess, Ke, Nees, Sn, Perry, Bj, Choi, M, Bodria, M, Liu, Y, Weng, Pl, Lozanovski, Vj, Verbitsky, M, Lugani, F, Sterken, R, Paragas, N, Caridi, G, Carrea, A, Dagnino, M, Materna Kiryluk, A, Santamaria, G, Murtas, C, Ristoska Bojkovska, N, Izzi, C, Kacak, N, Bianco, B, Giberti, S, Gigante, M, Piaggio, G, Gesualdo, L, Kosuljandic Vukic, D, Vukojevic, K, Saraga Babic, M, Saraga, M, Gucev, Z, Allegri, L, Latos Bielenska, A, Casu, D, State, M, Scolari, F, Ravazzolo, Roberto, Kiryluk, K, Al Awqati, Q, D'Agati, Vd, Drummond, Ia, Tasic, V, Lifton, Rp, Ghiggeri, Gm, and Gharavi, Ag

Subjects
Male, Kidney Disease, Genetic Linkage, 030232 urology & nephrology, Genome-wide association study, Bioinformatics, medicine.disease_cause, Fibroblast growth factor, Kidney, Medical and Health Sciences, Mice, 0302 clinical medicine, 2.1 Biological and endogenous factors, Exome, RNA, Small Interfering, Aetiology, Urinary Tract, Child, Pediatric, 0303 health sciences, Mutation, General Medicine, 3. Good health, Pedigree, medicine.anatomical_structure, Receptor-Interacting Protein Serine-Threonine Kinases, Gene Knockdown Techniques, Female, Biotechnology, Adult, Urologic Diseases, Heterozygote, Urinary system, 1.1 Normal biological development and functioning, Molecular Sequence Data, Renal and urogenital, Small Interfering, 03 medical and health sciences, Young Adult, Clinical Research, Underpinning research, General & Internal Medicine, medicine, Genetics, Animals, Humans, 030304 developmental biology, Base Sequence, business.industry, Human Genome, Infant, Heterozygote advantage, Urogenital Abnormalities, Etiology, RNA, Congenital Structural Anomalies, business, Genome-Wide Association Study
Abstract

BackgroundCongenital abnormalities of the kidney and the urinary tract are the most common cause of pediatric kidney failure. These disorders are highly heterogeneous, and the etiologic factors are poorly understood.MethodsWe performed genomewide linkage analysis and whole-exome sequencing in a family with an autosomal dominant form of congenital abnormalities of the kidney or urinary tract (seven affected family members). We also performed a sequence analysis in 311 unrelated patients, as well as histologic and functional studies.ResultsLinkage analysis identified five regions of the genome that were shared among all affected family members. Exome sequencing identified a single, rare, deleterious variant within these linkage intervals, a heterozygous splice-site mutation in the dual serine-threonine and tyrosine protein kinase gene (DSTYK). This variant, which resulted in aberrant splicing of messenger RNA, was present in all affected family members. Additional, independent DSTYK mutations, including nonsense and splice-site mutations, were detected in 7 of 311 unrelated patients. DSTYK is highly expressed in the maturing epithelia of all major organs, localizing to cell membranes. Knockdown in zebrafish resulted in developmental defects in multiple organs, which suggested loss of fibroblast growth factor (FGF) signaling. Consistent with this finding is the observation that DSTYK colocalizes with FGF receptors in the ureteric bud and metanephric mesenchyme. DSTYK knockdown in human embryonic kidney cells inhibited FGF-stimulated phosphorylation of extracellular-signal-regulated kinase (ERK), the principal signal downstream of receptor tyrosine kinases.ConclusionsWe detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. (Funded by the National Institutes of Health and others.).

Published
2013

13. Phosphate levels in patients treated with low-flux haemodialysis, pre-dilution haemofiltration and haemodiafiltration: post hoc analysis of a multicentre, randomized and controlled trial

Author

Locatelli, F., primary, Altieri, P., additional, Andrulli, S., additional, Sau, G., additional, Bolasco, P., additional, Pedrini, L. A., additional, Basile, C., additional, David, S., additional, Gazzanelli, L., additional, Tampieri, G., additional, Isola, E., additional, Marzolla, O., additional, Memoli, B., additional, Ganadu, M., additional, Reina, E., additional, Bertoli, S., additional, Ferrara, R., additional, Casu, D., additional, Logias, F., additional, Tarchini, R., additional, Mattana, G., additional, Passaghe, M., additional, Fundoni, G., additional, Villa, G., additional, Di Iorio, B. R., additional, Pontoriero, G., additional, and Zoccali, C., additional

Published
2014
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16. I Policheti meiobentonici delle Secche della Meloria

Author

Casu, D., Milella, I., Castelli, A., and Todaro, Mary Antonio Donatello

Subjects
annelida, Policheti, invertebrati, benthos, mediterraneo, Meloria, meiofauna, fauna italiana, zoologia
Published
2000

17. Predictors of haemoglobin levels and resistance to erythropoiesis-stimulating agents in patients treated with low-flux haemodialysis, haemofiltration and haemodiafiltration: results of a multicentre randomized and controlled trial

Author

Locatelli, F., primary, Altieri, P., additional, Andrulli, S., additional, Sau, G., additional, Bolasco, P., additional, Pedrini, L. A., additional, Basile, C., additional, David, S., additional, Feriani, M., additional, Nebiolo, P. E., additional, Ferrara, R., additional, Casu, D., additional, Logias, F., additional, Tarchini, R., additional, Cadinu, F., additional, Passaghe, M., additional, Fundoni, G., additional, Villa, G., additional, Di Iorio, B. R., additional, and Zoccali, C., additional

Published
2012
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18. Extracorporeal dialysis: techniques and adequacy

Author

Donadio, C., primary, Kanaki, A., additional, Martin-Gomez, A., additional, Garcia, S., additional, Palacios-Gomez, M., additional, Donadio, C., additional, Calia, D., additional, Colombini, E., additional, DI Francesco, F., additional, Ghimenti, S., additional, Onor, M., additional, Tognotti, D., additional, Fuoco, R., additional, Marka-Castro, E., additional, Torres Zamora, M. I., additional, Giron-Mino, J., additional, Jaime-Solis, M. A., additional, Arteaga, L. M., additional, Romero, H., additional, Akonur, A., additional, Leypoldt, K., additional, Asola, M., additional, Culleton, B., additional, Eloot, S., additional, Glorieux, G., additional, Nathalie, N., additional, Vanholder, R., additional, Perez de Jose, A., additional, Verdalles Guzman, U., additional, Abad Esttebanez, S., additional, Vega Martinez, A., additional, Barraca, D., additional, Yuste, C., additional, Bucalo, L., additional, Rincon, A., additional, Lopez-Gomez, J. M., additional, Bataille, P., additional, Celine, P., additional, Raymond, A., additional, Francois, G., additional, Herve, L., additional, Michel, D., additional, Jean Louis, R., additional, Zhu, F., additional, Kotanko, P., additional, Thijssen, S., additional, Levin, N. W., additional, Papamichail, N., additional, Bougiakli, M., additional, Gouva, C., additional, Antoniou, S., additional, Gianitsi, S., additional, Vlachopanou, A., additional, Chachalos, S., additional, Naka, K., additional, Kaarsavvidou, D., additional, Katopodis, K., additional, Michalis, L., additional, Sasaki, K., additional, Yasuda, K., additional, Yamato, M., additional, Surace, A., additional, Rovatti, P., additional, Steckiph, D., additional, Bandini, R., additional, Severi, S., additional, Dellacasa Bellingegni, A., additional, Santoro, A., additional, Arias, M., additional, Sentis, A., additional, Perez, N., additional, Fontsere, N., additional, Vera, M., additional, Rodriguez, N., additional, Arcal, C., additional, Ortega, N., additional, Uriza, F., additional, Cases, A., additional, Maduell, F., additional, Abbas, S. R., additional, Georgianos, P., additional, Sarafidis, P., additional, Nikolaidis, P., additional, Lasaridis, A., additional, Ahmed, A., additional, Kaoutar, H., additional, Mohammed, B., additional, Zouhir, O., additional, Balter, P., additional, Ginsberg, N., additional, Taylor, P., additional, Sullivan, T., additional, Usvyat, L. A., additional, Zabetakis, P., additional, Moissl, U., additional, Ferrario, M., additional, Garzotto, F., additional, Wabel, P., additional, Cruz, D., additional, Tetta, C., additional, Signorini, M. G., additional, Cerutti, S., additional, Brendolan, A., additional, Ronco, C., additional, Heaf, J., additional, Axelsen, M., additional, Pedersen, R. S., additional, Amine, H., additional, Oualim, Z., additional, Ammirati, A. L., additional, Guimaraes de Souza, N. K., additional, Nemoto Matsui, T., additional, Luiz Vieira, M., additional, Alves de Oliveira, W. A., additional, Fischer, C. H., additional, Dias Carneiro, F., additional, Iizuka, I. J., additional, Aparecida de Souza, M., additional, Mallet, A. C., additional, Cruz Andreoli, M. C., additional, Cardoso Dos Santos, B. F., additional, Rosales, L., additional, Dou, Y., additional, Carter, M., additional, Testa, A., additional, Sottini, L., additional, Giacon, B., additional, Prati, E., additional, Loschiavo, C., additional, Brognoli, M., additional, Marseglia, C., additional, Tommasi, A., additional, Sereni, L., additional, Palladino, G., additional, Bove, S., additional, Bosticardo, G., additional, Schillaci, E., additional, Detoma, P., additional, Bergia, R., additional, Park, J. W., additional, Moon, S. J., additional, Choi, H. Y., additional, Ha, S. K., additional, Park, H.-C., additional, Liao, Y., additional, Zhang, L., additional, Fu, P., additional, Igarashi, H., additional, Suzuki, N., additional, Esashi, S., additional, Masakane, I., additional, Panichi, V., additional, De Ferrari, G., additional, Saffiotti, S., additional, Sidoti, A., additional, Biagioli, M., additional, Bianchi, S., additional, Imperiali, P., additional, Gabrielli, C., additional, Conti, P., additional, Patrone, P., additional, Rombola, G., additional, Falqui, V., additional, Mura, C., additional, Icardi, A., additional, Rosati, A., additional, Santori, F., additional, Mannarino, A., additional, Bertucci, A., additional, Jeong, J., additional, Kim, O. K., additional, Kim, N. H., additional, Bots, M., additional, Den Hoedt, C., additional, Grooteman, M. P., additional, Van der Weerd, N. C., additional, Mazairac, A. H. A., additional, Levesque, R., additional, Ter Wee, P. M., additional, Nube, M. J., additional, Blankestijn, P., additional, Van den Dorpel, M. A., additional, Park, Y., additional, Jeon, J., additional, Tessitore, N., additional, Bedogna, V., additional, Girelli, D., additional, Corazza, L., additional, Jacky, P., additional, Guillaume, Q., additional, Julien, B., additional, Marcinkowski, W., additional, Drozdz, M., additional, Milkowski, A., additional, Rydzynska, T., additional, Prystacki, T., additional, August, R., additional, Benedyk-Lorens, E., additional, Bladek, K., additional, Cina, J., additional, Janiszewska, G., additional, Kaczmarek, A., additional, Lewinska, T., additional, Mendel, M., additional, Paszkot, M., additional, Trafidlo, E., additional, Trzciniecka-Kloczkowska, M., additional, Vasilevsky, A., additional, Konoplev, G., additional, Lopatenko, O., additional, Komashnya, A., additional, Visnevsky, K., additional, Gerasimchuk, R., additional, Neivelt, I., additional, Frorip, A., additional, Vostry, M., additional, Racek, J., additional, Rajdl, D., additional, Eiselt, J., additional, Malanova, L., additional, Pechter, U., additional, Selart, A., additional, Ots-Rosenberg, M., additional, Krieter, D. H., additional, Seidel, S., additional, Merget, K., additional, Lemke, H.-D., additional, Wanner, C., additional, Canaud, B., additional, Rodriguez, A., additional, Morgenroth, A., additional, Von Appen, K., additional, Dragoun, G.-P., additional, Fluck, R., additional, Fouque, D., additional, Lockridge, R., additional, Motomiya, Y., additional, Uji, Y., additional, Hiramatsu, T., additional, Ando, Y., additional, Furuta, M., additional, Kuragano, T., additional, Kida, A., additional, Yahiro, M., additional, Otaki, Y., additional, Hasuike, Y., additional, Nonoguchi, H., additional, Nakanishi, T., additional, Sain, M., additional, Kovacic, V., additional, Ljutic, D., additional, Radic, J., additional, Jelicic, I., additional, Yalin, S. F., additional, Trabulus, S., additional, Yalin, A. S., additional, Altiparmak, M. R., additional, Serdengecti, K., additional, Ohtsuka, A., additional, Fukami, K., additional, Ishikawa, K., additional, Ando, R., additional, Kaida, Y., additional, Adachi, T., additional, Sugi, K., additional, Okuda, S., additional, Nesterova, O. B., additional, Suglobova, E. D., additional, Golubev, R. V., additional, Vasiliev, A. N., additional, Lazeba, V. A., additional, Smirnov, A. V., additional, Arita, K., additional, Kihara, E., additional, Maeda, K., additional, Oda, H., additional, Doi, S., additional, Masaki, T., additional, Hidaka, S., additional, Ishioka, K., additional, Oka, M., additional, Moriya, H., additional, Ohtake, T., additional, Nomura, S., additional, Kobayashi, S., additional, Wagner, S., additional, Gmerek, A., additional, Wagner, J., additional, Wizemann, V., additional, Eftimovska - Otovic, N., additional, Spaseska-Gjurovska, K., additional, Bogdanovska, S., additional, Babalj - Banskolieva, E., additional, Milovanceva, M., additional, Grozdanovski, R., additional, Pisani, A., additional, Riccio, E., additional, Mancini, A., additional, Ambuhl, P., additional, Astrid, S., additional, Ivana, P., additional, Martin, H., additional, Thomas, K., additional, Hans-Rudolf, R., additional, Daniel, A., additional, Denes, K., additional, Marco, M., additional, Wuthrich, R. P., additional, Andreas, S., additional, Andrulli, S., additional, Altieri, P., additional, Sau, G., additional, Bolasco, P., additional, Pedrini, L. A., additional, Basile, C., additional, David, S., additional, Feriani, M., additional, Nebiolo, P. E., additional, Ferrara, R., additional, Casu, D., additional, Logias, F., additional, Tarchini, R., additional, Cadinu, F., additional, Passaghe, M., additional, Fundoni, G., additional, Villa, G., additional, DI Iorio, B. R., additional, Zoccali, C., additional, Locatelli, F., additional, Hamamoto, M., additional, Lee, D.-Y., additional, Kim, B., additional, Moon, K. H., additional, LI, Z., additional, Ahrenholz, P., additional, Winkler, R. E., additional, Waitz, G., additional, Wolf, H., additional, Grundstrom, G., additional, Alquist, M., additional, Holmquist, M., additional, Christensson, A., additional, Bjork, P., additional, Abdgawad, M., additional, Ekholm, L., additional, Segelmark, M., additional, Corsi, C., additional, De Bie, J., additional, Mambelli, E., additional, Mortara, D., additional, Arroyo, D., additional, Panizo, N., additional, Quiroga, B., additional, Reque, J., additional, Melero, R., additional, Rodriguez-Ferrero, M., additional, Rodriguez-Benitez, P., additional, Anaya, F., additional, Luno, J., additional, Ragon, A., additional, James, A., additional, Brunet, P., additional, Ribeiro, S., additional, Faria, M. S., additional, Rocha, S., additional, Rodrigues, S., additional, Catarino, C., additional, Reis, F., additional, Nascimento, H., additional, Fernandes, J., additional, Miranda, V., additional, Quintanilha, A., additional, Belo, L., additional, Costa, E., additional, Santos-Silva, A., additional, Arund, J., additional, Tanner, R., additional, Fridolin, I., additional, Luman, M., additional, Clajus, C., additional, Kielstein, J. T., additional, Haller, H., additional, Libutti, P., additional, Lisi, P., additional, Vernaglione, L., additional, Casucci, F., additional, Losurdo, N., additional, Teutonico, A., additional, Lomonte, C., additional, Krisp, C., additional, Wolters, D. A., additional, Matsuyama, M., additional, Tomo, T., additional, Ishida, K., additional, Matsuyama, K., additional, Nakata, T., additional, Kadota, J., additional, Caiazzo, M., additional, Monari, E., additional, Cuoghi, A., additional, Bellei, E., additional, Bergamini, S., additional, Tomasi, A., additional, Baranger, T., additional, Seniuta, P., additional, Berge, F., additional, Drouillat, V., additional, Frangie, C., additional, Rosier, E., additional, Labonia, W., additional, Lescano, A., additional, Rubio, D., additional, Von der Lippe, N., additional, Jorgensen, J. A., additional, Osthus, T. B., additional, Waldum, B., additional, Os, I., additional, Bossola, M., additional, DI Stasio, E., additional, Antocicco, M., additional, Tazza, L., additional, Griveas, I., additional, Karameris, A., additional, Pasadakis, P., additional, Savica, V., additional, Santoro, D., additional, Saitta, S., additional, Tigano, V., additional, Bellinghieri, G., additional, Gangemi, S., additional, Daniela, R., additional, Checherita, I. A., additional, Ciocalteu, A., additional, Vacaroiu, I. A., additional, Niculae, A., additional, Stefaniak, E., additional, Pietrzak, I., additional, Krupa, D., additional, Garred, L., additional, Mancini, E., additional, Corrazza, L., additional, Atti, M., additional, Afsar, B., additional, Stamopoulos, D., additional, Mpakirtzi, N., additional, Gogola, B., additional, Zeibekis, M., additional, Stivarou, D., additional, Panagiotou, M., additional, Grapsa, E., additional, Vega Vega, O., additional, Barraca Nunez, D., additional, Fernandez-Lucas, M., additional, Gomis, A., additional, Teruel, J. L., additional, Elias, S., additional, Quereda, C., additional, Hignell, L., additional, Humphrey, S., additional, Pacy, N., additional, and Afentakis, N., additional

Published
2012
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19. Hemodiafiltration with Endogenous Reinfusion with and without Acetate-Free Dialysis Solutions: Effect on ESA Requirement

Author

Bolasco, P.G., primary, Ghezzi, P.M., additional, Serra, A., additional, Corazza, L., additional, Murtas, S., additional, Mascia, M., additional, Cossu, M., additional, Ferrara, R., additional, Cogoni, G., additional, Cadinu, F., additional, Casu, D., additional, Contu, B., additional, Passaghe, M., additional, Ghisu, T., additional, Ganadu, M., additional, and Logias, F., additional

Published
2011
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21. On-Line Predilution Hemofiltration versus Ultrapure High-Flux Hemodialysis: A Multicenter Prospective Study in 23 Patients

Author

Altieri, P., primary, Sorba, G.B., additional, Bolasco, P.G, additional, Bostrom, M., additional, Asproni, E., additional, Ferrara, R., additional, Bolasco, F., additional, Cossu, M., additional, Cadinu, F., additional, Cabiddu, G.F., additional, Casu, D., additional, Ganadu, M., additional, Passaghe, M., additional, and Pinna, M., additional

Published
1997
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22. New Method for Phosphate Kinetics Estimation during Hemodialysis and On-Line Hemodiafiltration with Endogenous Reinfusion

Author

Bolasco, P., Ghezzi, P.M., Ferrara, R., Cogoni, G., Cadinu, F., Casu, D., and Murtas, S.

Abstract

AbstractAim: The purpose of this study was to optimize the operative and analytical methodologies to a more exact determination of intradialytic kinetics of the phosphates (P) tested in hemodialysis (HD) and in on-line hemodiafiltration with endogenous reinfusion (HFR – Hemo Filtrate Reinfusion). Methods: The mass balance measurements of urea and P were carried out in 18 clinically stable HD patients. The effective blood flow (Qb) was measured with a Transonic® monitor. The plasma was deproteinized with 10% trichloroacetic acid to prevent breakdown of the proteins and the consequent pseudohyperphosphatemia. Subsequently the supernatant containing the ultrafiltrable phosphates was made to react with a solution of ammonium molybdate for a spectrophotometric reading. Results: The mean urea mass transfer in HD was 16.9 g/session and in HFR 15.4 g/session. The mean P mass transfer in HD was 726 mg/session and in HFR 679 mg/session. Nevertheless, in HFR a significant difference was verified between the clearances of P, between the plasma water side (122.4 ± 30.8 ml/min) and the dialysate side (105.9 ± 19.4 ml/min). Conclusion: As far as the P mass transfer is concerned, the data obtained is able to be superimposed with that described in the literature during HD, while in HFR it is possible to hypothesize a high efficiency, thanks to an increased output of P in relation to the phenomenon of adsorption which, although is limited, contributes to the transfer of the total mass. Based on this study and re-examining the literature on P kinetics, there is space for methodological improvement both on the operating front with careful determination of the effective Qb, and on the chemical front overcoming the inaccuracy of automatic analyzers in determining the plasma P owing to possible overestimation of phosphatemia and poor sensitivity in measuring the lower levels of P present in the dialysate and/or ultrafiltrate.Copyright © 2006 S. Karger AG, Basel

Published
2006
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23. Identification of a new mutation in the alpha4(IV) collagen gene in a family with autosomal dominant Alport syndrome and hypercholesterolaemia.

Author

Ciccarese, M, Casu, D, Ki Wong, F, Faedda, R, Arvidsson, S, Tonolo, G, Luthman, H, and Satta, A

Abstract

Alport syndrome (AS) is a hereditary disease of the glomerular basement membrane in the kidney characterized by progressive renal failure, sensorineural deafness, and/or ocular abnormalities. In contrast to the well-known X-linked phenotype, very little is known about the autosomal dominant form. Rare autosomal forms of AS have been described with mutations in COL4A3 and COL4A4 at chromosome region 2q35-q37, but there have been no descriptions of dominant forms due to a mutation in COL4A4.

Published
2001
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24. Predilution haemofiltration--the Second Sardinian Multicentre Study: comparisons between haemofiltration and haemodialysis during identical Kt/V and session times in a long-term cross-over study.

Author

Altieri, P, Sorba, G, Bolasco, P, Asproni, E, Ledebo, I, Cossu, M, Ferrara, R, Ganadu, M, Cadinu, F, Serra, G, Cabiddu, G, Sau, G, Casu, D, Passaghe, M, Bolasco, F, Pistis, R, and Ghisu, T

Abstract

The potential superiority of various renal replacement treatment modalities consisting largely of convective mass transfer as opposed to primarily diffusive mass transfer, is still a matter of debate. The objective of the present study was to evaluate acute and long-term clinical effects of varying degrees of convection and diffusion in a group of 24 clinically stable patients with end-stage renal disease.

Published
2001
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26. [Effects of Dose of Erythropoiesis Stimulating Agents on Cardiovascular Outcomes, Quality of Life and Costs of Haemodialysis. The Clinical Evaluation of the DOSe of Erythropoietins (C.E. DOSE) Trial]

Author

Saglimbene V, D'Alonzo D, Ruospo M, Vecchio M, Natale P, Gargano L, Nicolucci A, Pellegrini F, Jc, Craig, Triolo G, Da, Procaccini, Santoro A, Giulio S, Rosa S, Murgo A, Mammarella R, Sambati M, D'Ambrosio N, Greco V, Giannoccaro G, Flammini A, Boccia E, Montalto G, Pagano S, Amarù S, Fici M, Lumaga G, Mancini E, Veronesi M, Patregnani L, Querques M, Schiavone P, Chimienti S, Palumbo R, Franco D, Volpe M, Gori E, Salomone M, Iacono A, Moscoloni M, Treglia A, Casu D, Am, Piras, Silva A, Mandreoli M, Lopez A, Quarello F, Catizone L, Russo G, Forcellini S, Maccarone M, Catucci G, Paolo B, Stingone A, D'Angelo B, Guastoni C, Pasquali S, Minoretti C, Bellasi A, Boscutti G, Martone M, David S, Schito F, Urban L, Iorio B, Caruso F, Mazzoni A, Musacchio R, Andreoli D, Cossu M, Cavoli G, Cornacchiari M, Granata A, Clementi A, Giordano R, Barzaghi W, Miriam Valentini, Hegbrant J, Tognoni G, and Gf, Strippoli

Subjects
Risk, Dose-Response Relationship, Drug, Disease Management, Anemia, Middle Aged, Hemoglobins, Observational Studies as Topic, Double-Blind Method, Meta-Analysis as Topic, Renal Dialysis, Research Design, Outcome Assessment, Health Care, Hematinics, Quality of Life, Humans, Kidney Failure, Chronic, Diabetic Nephropathies, Female
Abstract

Anaemia is a risk factor for death, adverse cardiovascular outcomes and poor quality of life in patients with chronic kidney disease (CKD). Erythropoietin Stimulating Agents (ESA) are the most used treatment option. In observational studies, higher haemoglobin (Hb) levels (around 11-13 g/dL) are associated with improved survival and quality of life compared to Hb levels around 9-10 g/dL. Randomized studies found that targeting higher Hb levels with ESA causes an increased risk of death, mainly due to adverse cardiovascular outcomes. It is possible that this is mediated by ESA dose rather than haemoglobin concentration, although this hypothesis has never been formally tested.We present the protocol of the Clinical Evaluation of the Dose of Erythropoietins (C.E. DOSE) trial, which will assess the benefits and harms of a high versus a low ESA dose therapeutic strategy for the management of anaemia of end stage kidney disease (ESKD). This is a randomized, prospective open label blinded end-point (PROBE) design trial due to enroll 900 haemodialysis patients. Patients will be randomized 1:1 to 4000 UI/week i. v. versus 18000 UI/week i. v. of epoetin alfa, beta or any other epoetin in equivalent doses. The primary outcome of the trial is a composite of cardiovascular events. In addition, quality of life and costs of these two strategies will be assessed. The study has been approved and funded by the Italian Agency of Drugs (Agenzia Italiana del Farmaco (AIFA)) within the 2006 funding plan for independent research on drugs (registered at www.clinicaltrials.gov (NCT00827021)).

28. Effects of dose of erythropoiesis stimulating agents on cardiovascular outcomes, quality of life and costs of haemodialysis. the clinical evaluation of the DOSe of erythropoietins (C.E. DOSE) Trial | Effetti della dose degli agenti stimolanti l'eritropoiesi su esiti cardio-cerebrovascolari, qualità di vita e costi in emodialisi

Author

Saglimbene, V., D Alonzo, D., Ruospo, M., Vecchio, M., Natale, P., Gargano, L., Nicolucci, A., Pellegrini, F., Craig, J. C., Triolo, G., Procaccini, D. A., Santoro, A., Di Giulio, S., La Rosa, S., Murgo, A., Di Toro Mammarella, R., Sambati, M., D Ambrosio, N., Greco, V., Giannoccaro, G., Flammini, A., Boccia, E., Giuseppe MONTALTO, Pagano, S., Amarù, S., Fici, M., Lumaga, G. B., Mancini, E., Veronesi, M., Patregnani, L., Querques, M., Schiavone, P., Chimienti, S., Palumbo, R., Di Franco, D., Della Volpe, M., Gori, E., Salomone, M., Iacono, A., Moscoloni, M., Treglia, A., Casu, D., Piras, A. M., Di Silva, A., Mandreoli, M., Lopez, A., Quarello, F., Catizone, L., Russo, G., Forcellini, S., Maccarone, M., Catucci, G., Di Paolo, B., Stingone, A., D Angelo, B., Guastoni, C., Pasquali, S., Minoretti, C., Bellasi, A., Boscutti, G., Martone, M., David, S., Schito, F., Urban, L., Di Iorio, B., Caruso, F., Mazzoni, A., Musacchio, R., Andreoli, D., Cossu, M., Li Cavoli, G., Cornacchiari, M., Granata, A., Clementi, A., Giordano, R., Barzaghi, W., Valentini, M., Hegbrant, J., Tognoni, G., and Strippoli, G. F.

32. Cancer diagnosis and suicide outcomes: Umbrella review and methodological considerations

Author

Raffaella Calati, Guendalina Gentile, Riccardo Zoja, Diego Casu, Stefano Tambuzzi, Jorge Lopez-Castroman, Giulia Peviani, Michele Fornaro, William Mansi, Fabio Madeddu, Chiara Filipponi, Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), University of Milan, 'Federico II' University of Naples Medical School, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Calati, R, Filipponi, C, Mansi, W, Casu, D, Peviani, G, Gentile, G, Tambuzzi, S, Zoja, R, Fornaro, M, Lopez-Castroman, J, and Madeddu, F

Subjects
Male, medicine.medical_specialty, Databases, Factual, [SDV]Life Sciences [q-bio], Population, 03 medical and health sciences, Umbrella review, 0302 clinical medicine, Suicidal behaviors, Neoplasms, Credibility, medicine, Humans, Meta-analysi, 030212 general & internal medicine, education, Aged, Cancer, education.field_of_study, business.industry, Public health, Publication bias, medicine.disease, 3. Good health, Psychiatry and Mental health, Clinical Psychology, Meta-analysis, Suicide, Systematic review, Standardized mortality ratio, Oncology, 030220 oncology & carcinogenesis, Family medicine, Suicidal behavior, business, Publication Bias, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background Suicide outcomes in cancer patients represent a major public health concern. We performed an umbrella review (UR) including all meta-analyses (MAs) and systematic reviews (SRs) published on the association between cancer and suicide outcomes. Methods Eligible studies were searched in the main scientific databases up to January 23rd, 2021. Eligible MAs/SRs focused on all suicide phenotypes among cancer patients. Evidence of the association was extracted; the credibility and quality of the included studies were evaluated using ad-hoc tools, including “A MeaSurement Tool to Assess systematic Reviews-2-Revised” (AMSTAR-2-R). Results Six MAs and 6 SRs were included. The standardized mortality ratio of suicide in cancer patients was 1.5 to 1.7-fold higher than in the general population. Risk factors for suicide outcomes among cancer patients were male sex and older age, a cancer diagnosis within the prior year, and some specific cancer sites. Among 107 associations, 90 (84.1%) were supported by high credibility of evidence (class II). However, all studies reported a large heterogeneity (I2> 50%) and the majority of them reported considerable heterogeneity (I2> 75%). All MAs used random-effects measures. All MAs but one assessed publication bias and only one disclosed it. The majority of MAs/SRs showed critically low quality based on AMSTAR-2-R. Limitations We could not perform additional analyses due to the limited number of MAs. Conclusions This UR underlines the inflated risk for suicide among cancer patients. Upcoming, well-designed studies are needed to account for a broader set of variables. Several methodological issues likewise warrant attention.

Published
2021
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33. Caulerpa racemosa var. cylindracea as a potential source of organic matter for benthic consumers: evidences from a stable isotope analysis

Author

Gianluca Sarà, Giulia Ceccherelli, Paola Rumolo, Daniela Casu, Nicola Sechi, Casu, D., Ceccherelli, G., Sechi, N., Rumolo, P., and Sarà, G.

Subjects
Settore BIO/07 - Ecologia, Polychaete, Detritus, biology, Cerithium, Ecology, Food source, Feeding habit, Aquatic Science, biology.organism_classification, Caulerpa racemosa, Rocky shore, Benthic zone, Botany, Zoobentho, Stable isotope ratio, Ecology, Evolution, Behavior and Systematics, Trophic level, Isotope analysis
Abstract

Caulerpa racemosa var. cylindracea has been invading various types of substrates in wide areas throughout the Mediterranean Sea. However, the effects of the distribution of this alga on zoobenthos are scanty. The aim of this study was to evaluate the effects of C. racemosa invasion on the feeding habits of some zoobenthic taxa inhabiting the upper infralittoral rocky shores. This was done by identifying the isotopic N and C ratios of several potential food sources and testing differences in isotope composition among the taxa collected from areas invaded and not-invaded areas by C. racemosa. Results suggest that C. racemosa detritus was a significant food source for the polychaete Syllis prolifera, the gammarid Corophium sextonae and the gastropods Cerithium rupestre and Pisinna glabrata. They would also suggest that stable carbon and nitrogen isotope ratios deserve further attention as a possible valuable approach to understand the overall effect of C. racemosa spread on the trophic interactions among the species. © Springer Science+Business Media B.V. 2008.

Published
2008

34. Sediment characteristics and macrofauna distribution along a human-modified inlet in the Gulf of Oristano (Sardinia, Italy)

Author

Paolo Magni, Serena Como, Daniela Casu, Ga A. Fenzi, Geraldina Signa, Gianmarco Giordani, S. Natale, G. De Falco, Antonello Floris, COMO, S, MAGNI, P, CASU, D, FLORIS, A, GIORDANI, G, NATALE, S, FENZI, GA, SIGNA, G, and DE FALCO, G

Subjects
Geologic Sediments, Cymodocea nodosa, coastal lagoons, Aquatic Science, Oceanography, Total organic carbon (TOC), Water Movements, Seawater, Organic matter, Particle Size, artificial structures, Ecosystem, Hydrology, Total organic carbon, chemistry.chemical_classification, geography, geography.geographical_feature_category, biology, Acid-volatile sulphides (AVS), benthic species richness, Sediment, Inlet, biology.organism_classification, Coastal lagoon, Pollution, Seagrass, Benthic species richne, Italy, chemistry, Benthic zone, Posidonia oceanica, Environmental science, Artificial structure, Seasons, Macrofauna
Abstract

We studied the spatial variability and within-year temporal changes in hydrological features, grain size composition and chemical characteristics of sediments, as well as macrofaunal assemblages, along a heavily modified inlet in the Gulf of Oristano (western Sardinia, Italy). The inlet connects the Cabras lagoon to the gulf through a series of convoluted creeks and man-made structures, including a dam and fish barriers built in the last three decades. Sediments were muddy and mainly composed of the "non-sortable" fraction (i.e., < 8 mu m particle size) in all four areas investigated: Lagoon, Creeks, Channel and Seaward. Along the inlet, however, the ratio between the < 8 mu mn and the 8-64 mu m fractions was highest in Creeks and Channel, between the fish barriers and the dam, suggesting impaired hydrodynamics. Consistently, steep gradients in water salinity, temperature and dissolved oxygen concentrations were found in proximity to the fish barriers. The whole inlet was characterized by a major organic enrichment of sediments, with up to an annual mean of 33.6% of organic matter and 11.7% of total organic carbon in Seaward due to the presence of seagrass leaf litter. Acid-volatile sulphide and chromium-reduced sulphur concentrations were highest throughout the year in Seaward and Lagoon, respectively, with a peak in summer. Consistently, the whole inlet supported low structured macrofaunal assemblages dominated by few opportunist species, with a relatively lower diversity in Lagoon throughout the year and the highest abundances in Seaward in summer. We infer that the presence of artificial structures along the inlet, such as fish barriers and the dam, impair the lagoon-gulf hydrodynamics, sediment exchange and animal recruitment and colonization. We suggest that the removal of these structures would favour water renewal in the Cabras lagoon, but would also increase the outflow of organic C-bonding fine particles into the gulf with serious consequences for Posidonia oceanica and Cymodocea nodosa seagrass meadows. We conclude that all possible consequences of such initiatives should be carefully considered before any action is taken. (C) 2007 Elsevier Ltd. All rights reserved.

Published
2007
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35. Cancer diagnosis and suicide outcomes: Umbrella review and methodological considerations.

Author

Calati R, Filipponi C, Mansi W, Casu D, Peviani G, Gentile G, Tambuzzi S, Zoja R, Fornaro M, Lopez-Castroman J, and Madeddu F

Subjects
Aged, Databases, Factual, Humans, Male, Publication Bias, Neoplasms epidemiology, Suicide
Abstract

Background: Suicide outcomes in cancer patients represent a major public health concern. We performed an umbrella review (UR) including all meta-analyses (MAs) and systematic reviews (SRs) published on the association between cancer and suicide outcomes., Methods: Eligible studies were searched in the main scientific databases up to January 23rd, 2021. Eligible MAs/SRs focused on all suicide phenotypes among cancer patients. Evidence of the association was extracted; the credibility and quality of the included studies were evaluated using ad-hoc tools, including "A MeaSurement Tool to Assess systematic Reviews-2-Revised" (AMSTAR-2-R)., Results: Six MAs and 6 SRs were included. The standardized mortality ratio of suicide in cancer patients was 1.5 to 1.7-fold higher than in the general population. Risk factors for suicide outcomes among cancer patients were male sex and older age, a cancer diagnosis within the prior year, and some specific cancer sites. Among 107 associations, 90 (84.1%) were supported by high credibility of evidence (class II). However, all studies reported a large heterogeneity (I 2 > 50%) and the majority of them reported considerable heterogeneity (I 2 > 75%). All MAs used random-effects measures. All MAs but one assessed publication bias and only one disclosed it. The majority of MAs/SRs showed critically low quality based on AMSTAR-2-R., Limitations: We could not perform additional analyses due to the limited number of MAs., Conclusions: This UR underlines the inflated risk for suicide among cancer patients. Upcoming, well-designed studies are needed to account for a broader set of variables. Several methodological issues likewise warrant attention., (Copyright © 2021. Published by Elsevier B.V.)

Published
2021
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36. Vitamins (A, C and E) and oxidative status of hemodialysis patients treated with HFR and HFR-Supra.

Author

Palleschi S, Ghezzi PM, Palladino G, Rossi B, Ganadu M, Casu D, Cossu M, Mattana G, Pinna AM, Contu B, Ghisu T, Monni A, Gazzanelli L, Mereu MC, Logias F, Passaghe M, Amore A, and Bolasco P

Subjects
Adult, Advanced Oxidation Protein Products blood, Aged, Aged, 80 and over, Cross-Over Studies, Female, Humans, Lipids blood, Male, Middle Aged, Oxidative Stress, Prospective Studies, Retinol-Binding Proteins, Plasma metabolism, Young Adult, Antioxidants metabolism, Ascorbic Acid blood, Hemodiafiltration methods, Kidney Failure, Chronic therapy, Vitamin A blood, Vitamin E blood
Abstract

Background: Hemodiafiltration with on-line endogenous reinfusion (HFR) is an extracorporeal dialytic method that combines diffusion, convection and adsorption. HFR-Supra (HFR-S) is a second-generation system with increased convective permeability and adsorption capability. Previous studies suggested that HFR reduces oxidative stress compared to standard haemodialysis. The principal aim of the present study was to compare antioxidant vitamins behavior and oxidative status of hemodialysis patients treated with HFR and HFR-S., Methods: The study was designed as a multicenter, randomized, crossover trial. Forty-one patients were recruited from 19 dialysis centers and after a 4-month washout stabilization period in on-line hemodiafiltration (ol-HDF), each patient was randomized to a sequence of treatments (HFR-S followed by HFR or viceversa) with each treatment applied over 6 months. Plasma levels of Advanced Oxidation Protein Products, Total Antioxidant Status, vitamins C, A and E and their ligands (Retinol Binding Protein and total lipids) were measured at baseline and at the end of each treatment period., Results: Results show that the higher convective permeability of HFR-S with respect to HFR did not produce additional beneficial effects on the patients' oxidative status, a slight decrease of both Vitamin A and Retinol Binding Protein being the only difference registered in the long-term. However, as compared to ol-HDF, both the re-infusive techniques allowed to reduce the intradialytic loss of Vitamin C and, in the long-term, improve the patients' oxidative status and increase Retinol Binding Protein plasma values. No significant differences were found between the Vitamin C concentration of pre- and post cartridge UF neither in HFR-S nor in HFR showing that the sorbent resin does not adsorb Vitamin C., Conclusion: HFR-S and HFR are almost equivalent in term of impact on antioxidant vitamins and oxidative status of hemodialysis patients. Nonetheless, as compared to ol-HDF, both treatments produced a sensible sparing of Vitamin C and may represent a new approach for reducing oxidative stress and related complications in dialysis patients. Long-term effects of re-infusive treatments on patients' cardiovascular morbidity and mortality need to be evaluated., Trial Registration: ClinicalTrials.gov Identifier NCT01492491 , retrospectively registered in 10 December 2011.

Published
2016
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37. [Effects of dose of erythropoiesis stimulating agents on cardiovascular outcomes, quality of life and costs of haemodialysis. the clinical evaluation of the DOSe of erythropoietins (C.E. DOSE) Trial].

Author

Saglimbene V, D'Alonzo D, Ruospo M, Vecchio M, Natale P, Gargano L, Nicolucci A, Pellegrini F, Craig JC, Triolo G, Procaccini DA, Santoro A, Di Giulio S, La Rosa S, Murgo A, Di Toro Mammarella R, Sambati M, D'Ambrosio N, Greco V, Giannoccaro G, Flammini A, Boccia E, Montalto G, Pagano S, Amarù S, Fici M, Lumaga GB, Mancini E, Veronesi M, Patregnani L, Querques M, Schiavone P, Chimienti S, Palumbo R, Di Franco D, Della Volpe M, Gori E, Salomone M, Iacono A, Moscoloni M, Treglia A, Casu D, Piras AM, Di Silva A, Mandreoli M, Lopez A, Quarello F, Catizone L, Russo G, Forcellini S, Maccarone M, Catucci G, Di Paolo B, Stingone A, D'Angelo B, Guastoni C, Pasquali S, Minoretti C, Bellasi A, Boscutti G, Martone M, David S, Schito F, Urban L, Di Iorio B, Caruso F, Mazzoni A, Musacchio R, Andreoli D, Cossu M, Li Cavoli G, Cornacchiari M, Granata A, Clementi A, Giordano R, Guastoni C, Barzaghi W, Valentini M, Hegbrant J, Tognoni G, and Strippoli GF

Subjects
Anemia economics, Anemia etiology, Diabetic Nephropathies complications, Disease Management, Dose-Response Relationship, Drug, Double-Blind Method, Female, Hematinics adverse effects, Hematinics economics, Hematinics pharmacology, Hematinics therapeutic use, Hemoglobins analysis, Humans, Kidney Failure, Chronic blood, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Meta-Analysis as Topic, Middle Aged, Observational Studies as Topic, Outcome Assessment, Health Care, Quality of Life, Research Design, Risk, Anemia drug therapy, Hematinics administration & dosage, Renal Dialysis adverse effects, Renal Dialysis economics
Abstract

Background: Anaemia is a risk factor for death, adverse cardiovascular outcomes and poor quality of life in patients with chronic kidney disease (CKD). Erythropoietin Stimulating Agents (ESA) are the most used treatment option. In observational studies, higher haemoglobin (Hb) levels (around 11-13 g/dL) are associated with improved survival and quality of life compared to Hb levels around 9-10 g/dL. Randomized studies found that targeting higher Hb levels with ESA causes an increased risk of death, mainly due to adverse cardiovascular outcomes. It is possible that this is mediated by ESA dose rather than haemoglobin concentration, although this hypothesis has never been formally tested., Methods: We present the protocol of the Clinical Evaluation of the Dose of Erythropoietins (C.E. DOSE) trial, which will assess the benefits and harms of a high versus a low ESA dose therapeutic strategy for the management of anaemia of end stage kidney disease (ESKD). This is a randomized, prospective open label blinded end-point (PROBE) design trial due to enroll 900 haemodialysis patients. Patients will be randomized 1:1 to 4000 UI/week i. v. versus 18000 UI/week i. v. of epoetin alfa, beta or any other epoetin in equivalent doses. The primary outcome of the trial is a composite of cardiovascular events. In addition, quality of life and costs of these two strategies will be assessed. The study has been approved and funded by the Italian Agency of Drugs (Agenzia Italiana del Farmaco (AIFA)) within the 2006 funding plan for independent research on drugs (registered at www.clinicaltrials.gov (NCT00827021)).

Published
2013

38. Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33.

Author

Sanna-Cherchi S, Caridi G, Weng PL, Dagnino M, Seri M, Konka A, Somenzi D, Carrea A, Izzi C, Casu D, Allegri L, Schmidt-Ott KM, Barasch J, Scolari F, Ravazzolo R, Ghiggeri GM, and Gharavi AG

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Chromosome Mapping, Female, Genetic Linkage, Genetic Markers, Genotype, Humans, Infant, Kidney pathology, Lod Score, Male, Middle Aged, Pedigree, Penetrance, Chromosomes, Human, Pair 1 genetics, Genes, Dominant physiology, Genetic Predisposition to Disease, Kidney abnormalities, Ureteral Diseases genetics
Abstract

Nonsyndromic defects in the urinary tract are the most common cause of end-stage renal failure in children and account for a significant proportion of adult nephropathy. The genetic basis of these disorders is not fully understood. We studied seven multiplex kindreds ascertained via an index case with a nonsyndromic solitary kidney or renal hypodysplasia. Systematic ultrasonographic screening revealed that many family members harbor malformations, such as solitary kidneys, hypodysplasia, or ureteric abnormalities (in a total of 29 affected individuals). A genomewide scan identified significant linkage to a 6.9-Mb segment on chromosome 1p32-33 under an autosomal dominant model with reduced penetrance (peak LOD score 3.5 at D1S2652 in the largest kindred). Altogether, three of the seven families showed positive LOD scores at this interval, demonstrating heterogeneity of the trait (peak HLOD 3.9, with 45% of families linked). The chromosome 1p32-33 interval contains 52 transcription units, and at least 23 of these are expressed at stage E12.5 in the murine ureteric bud and/or metanephric mesenchyme. These data show that autosomal dominant nonsyndromic renal hypodysplasia and associated urinary tract malformations are genetically heterogeneous and identify a locus for this common cause of human kidney failure.

Published
2007
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39. Human exclusion from rocky shores in a mediterranean marine protected area (MPA): an opportunity to investigate the effects of trampling.

Author

Casu D, Ceccherelli G, Curini-Galletti M, and Castelli A

Subjects
Animals, Environmental Monitoring, Humans, Italy, Mediterranean Sea, Population Dynamics, Recreation, Conservation of Natural Resources, Invertebrates physiology, Walking
Abstract

The effect of human trampling on the abundance of small invertebrates inhabiting rocky shallow bottoms was studied at Asinara Island MPA. To this aim we have conducted two experiments. The first was a quantitative study and tested the hypothesis that small invertebrates are more abundant at no-entry locations than at the location visited by tourists through time (before, during and after tourist season). The second was a manipulative experiment and tested the hypothesis that the abundance of small invertebrates is indirectly related to experimental trampling intensities. The effect due to tourist visitation was not highlighted on overall assemblages, suggesting that present seasonal tourist load at the MPA does not cause a significantly negative effect on the zoobenthic community studied. Although tourists exhibited trampling activity at the visited location, none of taxa examined showed a significant lower abundance during and strictly after the end of seasonal tourism peak in the visited location, rather than at control locations. However, results obtained with the second experiment suggested that the effects of different experimental trampling intensities on small invertebrates were variable among taxa. The experimental trampling caused immediate declines in the density of tanaids, nematodes, acari, bivalves, gammarids, echinoderms, isopods, and harpacticoids. For some of these taxa a recovery in abundance was observed within one month. This kind of data may offer important information to estimate the number of visitors compatible with the sensitivity of zoobenthic assemblages, and may substantially contribute to appropriate MPA management.

Published
2006
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40. Evaluating the effects of protection on two benthic habitats at Tavolara-Punta Coda Cavallo MPA (North-East Sardinia, Italy).

Author

Ceccherelli G, Casu D, Pala D, Pinna S, and Sechi N

Subjects
Analysis of Variance, Animals, Environmental Monitoring, Eukaryota classification, Invertebrates classification, Italy, Population Density, Conservation of Natural Resources, Ecosystem, Environment, Eukaryota physiology, Invertebrates physiology
Abstract

In this paper, two benthic habitats have been investigated in a fully protected site and two control sites at the Tavolara-Punta Coda Cavallo marine protected area (MPA) (NE Sardinia). Overall, a protection effect on the benthic assemblages was highlighted in the shallow subtidal (5 m deep) rather than at intertidal algal turf habitat. Structure of assemblages at the shallow subtidal habitat is different in the fully protected site vs. controls, while this was not true for the intertidal habitat. At the subtidal, this finding is probably linked to indirect effects due to an increase of consumers in the protected site (e.g., sea urchins), while the lack of direct impacts in the intertidal at control sites is indicative of very similar assemblages. Cover of encrusting algae was significantly higher at the subtidal protected site suggesting a possible higher grazing pressure. Possible causes underlying the inconsistency of results obtained between habitats include the possibility that trophic cascade effects have a different influence at different heights on the shore. The need to estimate the interconnection among benthic habitats through trophic links is also highlighted to provide an estimate of the vulnerability to protection of various habitats.

Published
2006
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41. Spatial variation of intertidal assemblages at Tavolara-Capo Coda Cavallo MPA (NE Sardinia): geographical vs. protection effect.

Author

Ceccherelli G, Casu D, and Sechi N

Subjects
Animals, Environmental Monitoring, Eukaryota, Geography, Geological Phenomena, Geology, Invertebrates, Italy, Population Dynamics, Conservation of Natural Resources, Ecosystem
Abstract

Marine protected areas (MPAs) represent a potentially useful management tool to preserve biodiversity. Protection effectiveness was investigated at Tavolara-Capo Coda Cavallo MPA by comparing assemblages of rocky shores at a location 'A' level of protection (island), with those at two locations at 'B' level of protection (one on an island and one on the mainland coast) and two at 'C' level of protection (one on an island and one on the mainland coast). Results did not indicate significant differences in structure of intertidal assemblages among locations under different levels of protection ('A', 'B' and 'C'). Protection was not found to be a significant source of variation to low-shore assemblages investigated. In contrast, assemblages seemed to be more dependent on the geographical location within the MPA. Results have important implications for conservation of marine coastal assemblages and would indicate that inclusion of representative assemblages within systems of marine protected areas should target rocky shores both on the mainland and on islands.

Published
2005
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42. Comparison between hemofiltration and hemodiafiltration in a long-term prospective cross-over study.

Author

Altieri P, Sorba G, Bolasco P, Ledebo I, Ganadu M, Ferrara R, Menneas A, Asproni E, Casu D, Passaghe M, Sau G, and Cadinu F

Subjects
Blood Pressure, Cross-Over Studies, Electric Impedance, Female, Humans, Kidney Failure, Chronic physiopathology, Kidney Failure, Chronic therapy, Male, Middle Aged, Hemodiafiltration, Hemofiltration
Abstract

Background: The objective of the study was to compare the convective treatment modes, on-line hemofiltration (HF) and on-line hemodiafiltration (HDF), regarding cardiovascular tolerance and effects on blood pressure, when applied under similar conditions in stable dialysis patients., Methods: 39 clinically stable dialysis patients were treated with HD for 6 months (run-in period), followed by HF and HDF in random order for 2x6 months. Similar biocompatibility (same membrane and fluid quality), similar treatment time and urea Kt/V were achieved using AK100/200 ULTRA machines, polyamide membranes in low-flux and high-flux versions and appropriate adjustment of blood flow rate (Qb) and dilution ratio (Qb/Qinf). Predilution was used for HDF (target dilution ratio = 2/1 ) as well as for HF (target dilution ratio = 1/1)., Results: 30 patients completed the study; 5 dropped out for non-study related reasons and 4 for non-compliance. Treatment with HF in comparison to HDF showed fewer hypotension episodes during the sessions per patient and month (HF: 0.5, HDF 1.1; p = 0.017), less plasma expander administration per patient and month (HF: 35.9 ml, HDF: 103.1 ml; p = 0.035), fewer episodes of intra-session headache (HF: 0.1, HDF: 0.4; p = 0.06), and higher pre-session MAP (HF: 98.4 mmHg, HDF: 93.8 mmHg; p = 0.037). No significant difference was found in inter-treatment weight gain, post-session MAP, or pre-session plasma sodium., Conclusions: HF and HDF provide good control of intra-session symptoms and blood pressure in stable patients. Treatment with HF resulted in a significant reduction in intra-session hypotension and a slight but significant increase in pre-session MAP, caused by an increase in systolic BP without any effect on the prevalence of hypertension or the dose of antihypertensive drugs, all compared to HDF.

Published
2004

43. Pre-dilution haemofiltration--the Sardinian multicentre studies: present and future. The Sardinian Collaborative Study Group on Haemofiltration On-Line.

Author

Altieri P, Sorba G, Bolasco P, Asproni E, Ledebo I, Boström M, Ferrara R, Ganadu M, Cossu M, Cadinu F, Cabiddu G, Serra G, Casu D, Bolasco F, Passaghe M, Ghisu T, Sau G, Ginanni A, Pistis R, Calvisi L, and Galfré A

Subjects
Adult, Aged, Cross-Over Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Renal Dialysis, Urea metabolism, Hemofiltration
Published
2000
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