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1. Arrhythmia detection using an implantable loop recorder after a negative electrophysiology study in Brugada syndrome: Observations from a multicenter international registry

Author

García-Izquierdo, Eusebio, Scrocco, Chiara, Palacios-Rubio, Julián, Assaf, Amira, Ripoll-Vera, Tomás, Hernandez-Betancor, Iván, Ramos-Ruiz, Pablo, Melero-Pita, Antonio, Segura-Domínguez, Melodie, Jiménez-Sánchez, Diego, Castro-Urda, Victor, Toquero-Ramos, Jorge, Yap, Sing-Chien, Behr, Elijah R., and Fernández-Lozano, Ignacio

Published
2024
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4. Right Bundle Branch Block Predicts Appropriate Implantable Cardioverter Defibrillator Therapies in Patients with Non-Ischemic Dilated Cardiomyopathy and a Prophylactic Implantable Cardioverter Defibrillator.

Author

Jiménez-Blanco Bravo, Marta, Alonso Salinas, Gonzalo Luis, Parra Esteban, Carolina, Toquero Ramos, Jorge, Amores Luque, Miguel, Zamorano Gómez, Jose Luis, García-Izquierdo, Eusebio, Álvarez-García, Jesús, Fernández Lozano, Ignacio, and Castro Urda, Víctor

Subjects
BUNDLE-branch block, IMPLANTABLE cardioverter-defibrillators, DILATED cardiomyopathy, CARDIAC arrest, VENTRICULAR arrhythmia
Abstract

Background: The benefit of prophylactic implantable cardioverter defibrillators (ICDs) in patients with severe systolic dysfunction of non-ischemic origin is still unclear, and the identification of patients at risk for sudden cardiac death remains a major challenge. Aims/Methods: We retrospectively reviewed all consecutive patients with non-ischemic dilated cardiomyopathy (NICM) who underwent prophylactic ICD implantation between 2008 and 2020 in two tertiary centers. Our main goal was to identify the predictors of appropriate ICD therapies (anti-tachycardia pacing [ATP] and/or shocks) in this cohort of patients. Results: A total of 224 patients were included. After a median follow-up of 51 months, 61 patients (27.2%) required appropriate ICD therapies. Patients with appropriate ICD therapies were more frequently men (87% vs. 69%, p = 0.006), of younger age (59 years, (53–65) vs. 64 years, (57–70); p = 0.02), showed more right bundle branch blocks (RBBBs) (15% vs. 4%, p = 0.007) and less left bundle branch blocks (LBBBs) (26% vs. 47%, p = 0.005) in the ECG, and had higher left ventricular end-diastolic (100 mL/m2, (90–117) vs. 86, (71–110); p = 0.011) and systolic volumes (72 mL/m2, (59–87) vs. 61, (47–81), p = 0.05). In a multivariate competing-risks regression analysis, RBBB (HR 2.26, CI 95% 1.02–4.98, p = 0.043) was identified as an independent predictor of appropriate ICD therapies. Conclusion: RBBBs may help to identify patients with NICM at high risk of ventricular arrhythmias and requiring ICD intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Feasibility and safety of left bundle branch area pacing in cardiac amyloidosis. A single center experience

Author

Pham‐Trung, Chinh, primary, Veloza‐Urrea, Darwin, additional, Segura‐Domínguez, Melodie, additional, De la Rosa Rojas, Yuleisy, additional, Aguilera‐Agudo, Cristina, additional, García‐Izquierdo, Eusebio Alejandro, additional, García‐Rodríguez, Daniel, additional, Jiménez‐Sánchez, Diego, additional, Lorente‐Ros, Alvaro, additional, Mingo‐Santos, Susana, additional, Gonzalez‐Lopez, Esther, additional, Domínguez, Fernando, additional, Garcia‐Pavia, Pablo, additional, Toquero‐Ramos, Jorge, additional, Fernández‐Lozano, Ignacio, additional, and Castro‐Urda, Víctor, additional

Published
2023
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7. Genetic analysis, in silico prediction, and family segregation in long QT syndrome

Author

Riuró, Helena, Campuzano, Oscar, Berne, Paola, Arbelo, Elena, Iglesias, Anna, Pérez-Serra, Alexandra, Coll-Vidal, Mònica, Partemi, Sara, Mademont-Soler, Irene, Picó, Ferran, Allegue, Catarina, Oliva, Antonio, Gerstenfeld, Edward, Sarquella-Brugada, Georgia, Castro-Urda, Víctor, Fernández-Lozano, Ignacio, Mont, Lluís, Brugada, Josep, Scornik, Fabiana S, and Brugada, Ramon

Subjects
Rare Diseases, Cardiovascular, Genetic Testing, Heart Disease, Genetics, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Computational Biology, Female, Genotype, Humans, KCNQ Potassium Channels, Long QT Syndrome, Male, Middle Aged, Mutation, Pedigree, Phenotype, Voltage-Gated Sodium Channels, Young Adult, Clinical Sciences, Genetics & Heredity
Abstract

The heritable cardiovascular disorder long QT syndrome (LQTS), characterized by prolongation of the QT interval on electrocardiogram, carries a high risk of sudden cardiac death. We sought to add new data to the existing knowledge of genetic mutations contributing to LQTS to both expand our understanding of its genetic basis and assess the value of genetic testing in clinical decision-making. Direct sequencing of the five major contributing genes, KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2, was performed in a cohort of 115 non-related LQTS patients. Pathogenicity of the variants was analyzed using family segregation, allele frequency from public databases, conservation analysis, and Condel and Provean in silico predictors. Phenotype-genotype correlations were analyzed statistically. Sequencing identified 36 previously described and 18 novel mutations. In 51.3% of the index cases, mutations were found, mostly in KCNQ1, KCNH2, and SCN5A; 5.2% of cases had multiple mutations. Pathogenicity analysis revealed 39 mutations as likely pathogenic, 12 as VUS, and 3 as non-pathogenic. Clinical analysis revealed that 75.6% of patients with QTc≥500 ms were genetically confirmed. Our results support the use of genetic testing of KCNQ1, KCNH2, and SCN5A as part of the diagnosis of LQTS and to help identify relatives at risk of SCD. Further, the genetic tools appear more valuable as disease severity increases. However, the identification of genetic variations in the clinical investigation of single patients using bioinformatic tools can produce erroneous conclusions regarding pathogenicity. Therefore segregation studies are key to determining causality.

Published
2015

9. Feasibility and safety of left bundle branch area pacing in cardiac amyloidosis. A single center experience.

Author

Pham‐Trung, Chinh, Veloza‐Urrea, Darwin, Segura‐Domínguez, Melodie, De la Rosa Rojas, Yuleisy, Aguilera‐Agudo, Cristina, García‐Izquierdo, Eusebio Alejandro, García‐Rodríguez, Daniel, Jiménez‐Sánchez, Diego, Lorente‐Ros, Alvaro, Mingo‐Santos, Susana, Gonzalez‐Lopez, Esther, Domínguez, Fernando, Garcia‐Pavia, Pablo, Toquero‐Ramos, Jorge, Fernández‐Lozano, Ignacio, and Castro‐Urda, Víctor

Subjects
CARDIAC amyloidosis, ECHOCARDIOGRAPHY, LEFT heart ventricle, PATIENT aftercare, VENTRICULAR ejection fraction, TIME, HEALTH outcome assessment, RETROSPECTIVE studies, CARDIAC pacing, ELECTROCARDIOGRAPHY, RESEARCH funding, PATIENT compliance, CARDIAC pacemakers, PEPTIDE hormones, PATIENT safety, HEART conduction system, EVALUATION
Abstract

Background: Conventional right ventricle (RV) pacemaker stimulation has been associated with worse clinical outcomes in patients with cardiac amyloidosis (CA). Left bundle branch area pacing (LABPP) has been suggested as a promising alternative. We sought to assess the safety, feasibility, and outcomes of LABPP in patients with CA. Methods: We retrospectively analyzed echocardiography and pacing parameters and clinical outcomes in 23 consecutive patients with CA and LBBAP implanted from June 2020 to October 2022. Results: LBBAP was successfully performed in 22 over 23 patients (19 male, 78.6 ± 11.7 years, 20 ATTR, mean LVEF 45.5 ± 16.2%). After the procedure, 9 patients showed Qr pattern and 11 a qR pattern in V1 on ECG. Average procedure time was 67 ± 28 min. After 7.7 ± 5.2 months follow‐up, no procedure‐related complications had occurred. Although, a significant reduction in QRS width (p =.001) was achieved, we did not observe significant changes in LVEF and Nt ProBNP at 6 months of follow‐up. Pacing parameters were stable during follow‐up: LBB capture threshold and R wave amplitude were 1.0 ± 0.5 V and 10.6 ± 6.0 mV versus 0.8 ± 0.1 V, p =.21 and 10.6 ± 5.1 mV (p =.985) at follow up. Conclusion: LBBAP is safe and feasible pacing technique for patients with CA. LBBAP is associated with significant narrowing of QRSd without worsening in LVEF and Nt‐proBNP. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Experience and insights from a prolonged electrocardiographic monitorization with a wearable system after an embolic stroke of unknown source

Author

de Castro, Daniel, primary, Toquero‐Ramos, Jorge, additional, Jiménez‐Sánchez, Diego, additional, García‐Izquierdo, Eusebio, additional, Castro‐Urda, Víctor, additional, Aguilera‐Agudo, Cristina, additional, Domínguez, Fernando, additional, García‐Rodríguez, Daniel, additional, Vela‐Martín, Paula, additional, Remior, Paloma, additional, Gómez‐Porro, Pablo, additional, Carneado‐Ruiz, Joaquín, additional, and Fernández‐Lozano, Ignacio, additional

Published
2023
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12. Efficacy and safety of Proglide use and early discharge after atrial fibrillation ablation compared to standard approach. PROFA trial.

Author

Castro‐Urda, Víctor, Segura‐Dominguez, Melodi, Jiménez‐Sánchez, Diego, Aguilera‐Agudo, Cristina, García‐Izquierdo, Eusebio, De la Rosa Rojas, Yuleisi, Pham‐Trung, Chinh, Hernández‐Terciado, Fernando, Lorente‐Ros, Alvaro, Matutano‐Muñoz, Andrea, García‐Rodriguez, Daniel, Toquero‐Ramos, Jorge, and Fernández‐Lozano, Ignacio

Subjects
*LENGTH of stay in hospitals, *CONFIDENCE intervals, *ATRIAL fibrillation, *MEDICAL care costs, *SURGICAL complications, *COST control, *TREATMENT effectiveness, *HOSPITAL admission & discharge, *COMPARATIVE studies, *RANDOMIZED controlled trials, *QUALITY of life, *COST effectiveness, *HOSPITAL care, *DESCRIPTIVE statistics, *RESEARCH funding, *STATISTICAL sampling, *VASCULAR closure devices, *PATIENT safety, *ABLATION techniques, *ECONOMICS, *DISEASE risk factors
Abstract

Background and Objectives: The common practice after atrial fibrillation ablation is to admit patients for an overnight stay. The aim of this study was to compare a strategy of vascular suture mediated closure system utilization and early discharge (strategy A) compared to traditional closure and overnight hospitalization (strategy B) regarding feasibility, safety, quality of life and health care cost effectiveness. Methods and Results: Hundred patients were randomized to compare both strategies. No clinical differences were reported except diabetes mellitus. Six patients (6%) had and emergency visit or were admitted in the first 30 days after procedure. Three occurred in strategy A versus three in strategy B (p = 1) (p <.005 for non‐inferiority). Forty out of 50 patients (80%) were safely discharged in a time frame of 3 h and 42 patients (84%) were discharged in the same day of the procedure in strategy A. Time to discharge was shorter in strategy A compared to strategy B. (5.89 ± 7.47 h vs. 27.09 ± 2.29 p <.005). No differences were obtained in quality‐of‐life outcomes. Mean (95% CI) euros cost saving per patient in strategy A was 379.16 ± 93.55 p <.001. Ten acute complications (10% patients CI 95% 4.02%–15.98%) were reported during the trial. Seven (14% CI 95% 4.04%–23.96%) occurred in strategy A patients versus 3 (6% CI 95% 0.8%–12.8%) in strategy B. (p =.182) Conclusion: A strategy of vascular suture mediated closure system utilization and early discharge was feasible, reduced time to discharge, saved costs and was not associated with more complications or admissions/emergency visits in a 30‐day time frame after procedure compared to a strategy of regular admission and discharge after overnight stay. There were no differences regarding quality‐of‐life parameters between both strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Trapped p waves causing loss of physiological left bundle branch pacing

Author

Castro, Daniel, primary, Aguilera‐Agudo, Cristina, additional, Castro‐Urda, Víctor, additional, Toquero, Jorge, additional, Jimenez‐Sanchez, Diego, additional, Vela‐Martín, Paula, additional, Veloza‐Urrea, Darwin, additional, Fernandez‐Lozano, Ignacio, additional, and García‐Izquierdo, Eusebio, additional

Published
2022
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16. Trapped p waves causing loss of physiological left bundle branch pacing.

Author

de Castro, Daniel, Aguilera‐Agudo, Cristina, Castro‐Urda, Víctor, Toquero, Jorge, Jimenez‐Sanchez, Diego, Vela‐Martín, Paula, Veloza‐Urrea, Darwin, Fernandez‐Lozano, Ignacio, and García‐Izquierdo, Eusebio

Subjects
ELECTIVE surgery, HEART valve prosthesis implantation, LEFT ventricular dysfunction, BUNDLE-branch block, AORTIC stenosis, SURGICAL complications, CARDIAC pacing, SEVERITY of illness index, HEART block, ELECTROCARDIOGRAPHY, CARDIAC pacemakers, ARRHYTHMIA, HIS bundle
Abstract

We present the case of a 75‐year‐old woman with severe aortic stenosis and moderate left ventricular dysfunction, who underwent elective transcatheter aortic valve replacement. After the procedure, the patient developed a left bundle branch block and a long PR interval. For this reason, a dual chamber pacemaker with pacing in the left bundle branch area was implanted. On device interrogation, we confirmed the presence of functional atrial undersensing causing loss of ventricular electric resynchronization. This case highlights the importance of recognizing this problem and, by means of device reprogramming and pharmacological intervention, suggests a stepwise approach to solve it. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Evaluación de la adherencia y la rentabilidad diagnóstica en detección de recurrencias tras ablación de fibrilación auricular mediante seguimiento con un dispositivo electrocardiograma portátil realizado por enfermería.

Author

Segura Domínguez, Melodie, Castro Urda, Víctor, Jiménez Sánchez, Diego, Aguilera Agudo, Cristina, Toquero Ramos, Jorge, García-Izquierdo Jaén, Eusebio, de Andrés Humanes, Jesús, Antequera Guirado, Ana, Vela Martín, Paula, and Fernández Lozano, Ignacio

Subjects
ATRIAL fibrillation diagnosis, EVALUATION of diagnostic imaging, OCCUPATIONAL roles, PATIENT aftercare, MEDICAL consultation, NURSING, SCIENTIFIC observation, CATHETER ablation, DISEASE relapse, COMPARATIVE studies, ELECTROCARDIOGRAPHY, NURSES, DESCRIPTIVE statistics, PATIENT compliance, MEDICAL equipment, LONGITUDINAL method, TELEMEDICINE
Abstract

Copyright of Enfermería en Cardiologia is the property of Asociacion Espanola de Enfermeria en Cardiologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

19. Benefits of cardiac pacing in ICD recipients with hypertrophic cardiomyopathy

Author

Jiménez-Sánchez, Diego, primary, Castro-Urda, Víctor, additional, Toquero-Ramos, Jorge, additional, Restrepo-Córdoba, María Alejandra, additional, Sánchez-García, Manuel, additional, García-Izquierdo, Eusebio, additional, Veloza, Darwin, additional, Baena-Herrera, Jorge, additional, González-López, Esther, additional, Domínguez, Fernando, additional, García-Pavía, Pablo, additional, and Fernández-Lozano, Ignacio, additional

Published
2021
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20. Incidencia, tasa de éxito, complicaciones y factores predictores de empleo de la vía femoral en procedimientos percutáneos de extracción de electrodos

Author

Castro-Urda, Víctor, primary, Toquero-Ramos, Jorge, additional, Sánchez-García, Manuel, additional, Jiménez-Sánchez, Diego, additional, Pham-Trung, Chinh, additional, Veloza-Urrea, Darwin, additional, Solís-Solís, Luis Diego, additional, Vázquez López-Ibor, Jorge, additional, Vilches-Soria, Silvia, additional, Cobo-Marcos, Marta, additional, Moñivas-Palomero, Vanessa, additional, and Fernández-Lozano, Ignacio, additional

Published
2020
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21. Registro Español de Ablación con Catéter. XVIII Informe Oficial de la Sección de Electrofisiología y Arritmias de la Sociedad Española de Cardiología (2018)

Author

Ibáñez Criado, José Luis, primary, Quesada, Aurelio, additional, Cózar, Rocío, additional, Almendral-Garrote, Jesús, additional, Alonso-Fernández, Pau, additional, Alonso-Martín, Concepción, additional, Alvarenga-Recalde, Nelson María, additional, Álvarez-Acosta, Luis, additional, Álvarez-López, Miguel, additional, Anguera-Camos, Ignasi, additional, Arana-Rueda, Eduardo, additional, Arcocha-Torres, María Fe, additional, Arias-Palomares, Miguel Ángel, additional, Asso-Abadía, Antonio, additional, Ballesteros-Derbenti, Gabriel Alejandro, additional, Barrera-Cordero, Alberto, additional, Benezet-Mazuecos, Juan, additional, Bodegas-Cañas, Andrés I., additional, Brugada-Terradellas, Josep, additional, Cabadés-Rumbeu, Claudia, additional, Cabanas-Grandío, María del Pilar, additional, Cabrera-Gómez, Sandra, additional, Cano-Calabria, Lucas R., additional, del Castillo-Arrojo, Silvia, additional, Castro-Urda, Víctor, additional, Cózar-León, Rocío, additional, Díaz-Infante, Ernesto, additional, Durán-Guerrero, Juan Manuel, additional, Elices-Teja, Juliana, additional, Expósito-Pineda, María del Carmen, additional, Fernández-Gómez, Juan Manuel, additional, Ferrer-Hita, Julio Jesús, additional, Fidalgo-Andrés, María Luisa, additional, Fontenla-Cerezuela, Adolfo, additional, García-Alberola, Arcadio, additional, García-Bolao, J. Ignacio, additional, García-Cuenca, Enrique, additional, García-Fernández, Francisco Javier, additional, Gil-Ortega, Ignacio, additional, Gómez-Pulido, Federico, additional, Grande-Ingelmo, Juan Manuel, additional, Guasch-i-Casany, Eduard, additional, Guerra-Ramos, José M., additional, Heras-Herreros, Santiago, additional, Hernández-Afonso, Julio, additional, Herreros-Guilarte, Benito, additional, Hidalgo-Olivares, Víctor Manuel, additional, Ibáñez-Criado, Alicia, additional, Ibáñez-Criado, José Luis, additional, Ibars-Campaña, Sonia, additional, Jáuregui-Abularach, Miguel Eduardo, additional, Jiménez-Candil, F. Javier, additional, Jiménez-Díaz, Javier, additional, Jiménez-López, Jesús I., additional, Lázaro-Rivera, Carla, additional, Lozano-Herrera, José Miguel, additional, Macías-Gallego, Alfonso, additional, Magnani-Ragamato, Santiago, additional, Martínez-Basterra, Javier, additional, Martínez-Brotons, Ángel, additional, Martínez-Sande, José Luis, additional, Martín-Sánchez, Gabriel, additional, Matías-Francés, Roberto, additional, Merino-Llorens, José Luis, additional, Mont-Girbau, Josep Lluis, additional, Moreno-Arribas, José, additional, Moreno-Planas, Javier, additional, Moya-i-Mitjans, Ángel, additional, Ortega-Molina, Marta, additional, Osca-Asensi, Joaquín, additional, Pastor-Fuentes, Agustín, additional, Pavón-Jiménez, Ricardo, additional, Peinado-Peinado, Rafael, additional, Pérez-Álvarez, Luisa, additional, Pérez-Castellano, Nicasio, additional, Porro-Fernández, Rosa, additional, Porta-Sánchez, Andreu, additional, Punti-Sala, Jordi, additional, Quesada-Dorador, Aurelio, additional, Rivas-Gándara, Nuria, additional, Rodrigo-Trallero, Gonzalo, additional, Rodríguez-Entem, Felipe José, additional, Rodríguez-Pérez, Juan Carlos, additional, Romero-Garrido, Rafael, additional, Rubín-López, José Manuel, additional, Rubio-Caballero, José Amador, additional, Rubio-Campal, José Manuel, additional, Rubio-Sanz, Jerónimo, additional, Ruiz-Hernández, Pablo M., additional, Salgado-Aranda, Ricardo, additional, Sánchez-Gómez, Juan Miguel, additional, Sarquella-Brugada, Georgia, additional, Sarrias-Mercé, Axel, additional, Segura-Saint-Gerons, Jose María, additional, Segura-Villalobos, Federico, additional, and Valverde-André, Irene, additional

Published
2019
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22. Spanish Catheter Ablation Registry. 18th Official Report of the Spanish Society of Cardiology Working Group on Electrophysiology and Arrhythmias (2018)

Author

Ibáñez Criado, José Luis, primary, Quesada, Aurelio, additional, Cózar, Rocío, additional, Almendral-Garrote, Jesús, additional, Alonso-Fernández, Pau, additional, Alonso-Martín, Concepción, additional, Alvarenga-Recalde, Nelson María, additional, Álvarez-Acosta, Luis, additional, Álvarez-López, Miguel, additional, Anguera-Camos, Ignasi, additional, Arana-Rueda, Eduardo, additional, Arcocha-Torres, María Fe, additional, Arias-Palomares, Miguel Ángel, additional, Asso-Abadía, Antonio, additional, Ballesteros-Derbenti, Gabriel Alejandro, additional, Barrera-Cordero, Alberto, additional, Benezet-Mazuecos, Juan, additional, Bodegas-Cañas, Andrés I., additional, Brugada-Terradellas, Josep, additional, Cabadés-Rumbeu, Claudia, additional, Cabanas-Grandío, María del Pilar, additional, Cabrera-Gómez, Sandra, additional, Cano-Calabria, Lucas R., additional, del Castillo-Arrojo, Silvia, additional, Castro-Urda, Víctor, additional, Cózar-León, Rocío, additional, Díaz-Infante, Ernesto, additional, Durán-Guerrero, Juan Manuel, additional, Elices-Teja, Juliana, additional, Expósito-Pineda, María del Carmen, additional, Fernández-Gómez, Juan Manuel, additional, Ferrer-Hita, Julio Jesús, additional, Fidalgo-Andrés, María Luisa, additional, Fontenla-Cerezuela, Adolfo, additional, García-Alberola, Arcadio, additional, García-Bolao, J. Ignacio, additional, García-Cuenca, Enrique, additional, García-Fernández, Francisco Javier, additional, Gil-Ortega, Ignacio, additional, Gómez-Pulido, Federico, additional, Grande-Ingelmo, Juan Manuel, additional, Guasch-i-Casany, Eduard, additional, Guerra-Ramos, José M., additional, Heras-Herreros, Santiago, additional, Hernández-Afonso, Julio, additional, Herreros-Guilarte, Benito, additional, Hidalgo-Olivares, Víctor Manuel, additional, Ibáñez-Criado, Alicia, additional, Ibáñez-Criado, José Luis, additional, Ibars-Campaña, Sonia, additional, Jáuregui-Abularach, Miguel Eduardo, additional, Jiménez-Candil, F. Javier, additional, Jiménez-Díaz, Javier, additional, Jiménez-López, Jesús I., additional, Lázaro-Rivera, Carla, additional, Lozano-Herrera, José Miguel, additional, Macías-Gallego, Alfonso, additional, Magnani-Ragamato, Santiago, additional, Martínez-Basterra, Javier, additional, Martínez-Brotons, Ángel, additional, Martínez-Sande, José Luis, additional, Martín-Sánchez, Gabriel, additional, Matías-Francés, Roberto, additional, Merino-Llorens, José Luis, additional, Mont-Girbau, Josep Lluis, additional, Moreno-Arribas, José, additional, Moreno-Planas, Javier, additional, Moya-i-Mitjans, Ángel, additional, Ortega-Molina, Marta, additional, Osca-Asensi, Joaquín, additional, Pastor-Fuentes, Agustín, additional, Pavón-Jiménez, Ricardo, additional, Peinado-Peinado, Rafael, additional, Pérez-Álvarez, Luisa, additional, Pérez-Castellano, Nicasio, additional, Porro-Fernández, Rosa, additional, Porta-Sánchez, Andreu, additional, Punti-Sala, Jordi, additional, Quesada-Dorador, Aurelio, additional, Rivas-Gándara, Nuria, additional, Rodrigo-Trallero, Gonzalo, additional, Rodríguez-Entem, Felipe José, additional, Rodríguez-Pérez, Juan Carlos, additional, Romero-Garrido, Rafael, additional, Rubín-López, José Manuel, additional, Rubio-Caballero, José Amador, additional, Rubio-Campal, José Manuel, additional, Rubio-Sanz, Jerónimo, additional, Ruiz-Hernández, Pablo M., additional, Salgado-Aranda, Ricardo, additional, Sánchez-Gómez, Juan Miguel, additional, Sarquella-Brugada, Georgia, additional, Sarrias-Mercé, Axel, additional, Segura-Saint-Gerons, Jose María, additional, Segura-Villalobos, Federico, additional, and Valverde-André, Irene, additional

Published
2019
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24. Incidence and Predictive Factors of Hidden Atrial Fibrillation Detected by Implantable Loop Recorder After an Embolic Stroke of Undetermined Source

Author

Cobo Marcos Marta, Mingo Santos Susana, Carneado-Ruiz Joaquín, Sánchez García Manuel, Pham Trung Chinh, Castro Urda Víctor, Toquero Ramos Jorge, Ortega Marcos Javier, Jiménez Sánchez Diego, Jiménez Ortiz Carlos, Fernández Villanueva José María, Parra Esteban Carolina, and Fernández Lozano Ignacio

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Incidence (epidemiology), Population, Atrial fibrillation, 030204 cardiovascular system & hematology, Single Center, medicine.disease, Asymptomatic, Embolic stroke, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cardiology, Left atrial enlargement, Implantable loop recorder, Medicine, 030212 general & internal medicine, medicine.symptom, Cardiology and Cardiovascular Medicine, business, education, Original Research
Abstract

BACKGROUND: The term embolic stroke of undetermined source (ESUS) has been defined for patients with ischemic strokes, where neither a cardioembolic nor a non-cardiac source can be detected. These patients may have asymptomatic episodes of atrial fibrillation (AF). Prolonged monitoring with implantable loop recorder (ILR) and daily remote interrogation in patients after an ESUS has shown an incidence of AF of about 25%. AIMS: The main objective of this study was to analyze the incidence and predictive factors of atrial fibrillation in patients with ESUS who underwent an ILR implantation. METHODS: It was a single center study. From June 2013 to January 2017 all consecutive patients with an ESUS, who underwent an ILR implantation searching for hidden AF, were included. Possible predictive factors of AF were also analyzed. RESULTS: 65 patients were included (mean age 65.4±13.8 years, 55.4% males, mean CHA2DS2VASc score 2.3± 1.5). After a median follow-up of 17.1±10.7 months, AF was detected in 19 (29.2%) of patients. Variables associated with AF were: age > 65 years (HR 9.45 (CI 95% 1.25-71.34); p= 0.02), CHA2DS2VASC score≥2 (HR 4.09 (CI 95% 0.93-17.87); p=0,06), left atrial enlargement (HR 2.29 (CI 95% 0.89-5.91); p=0.08) and presence of Supraventricular premature complex(SVC) on 24-hour Holter (HR 4.05 (CI 95% 1.55-10.57); p = 0.004) A cut-point of 0.15% for SVC was identified to predict AF with a sensitivity and specificity of 88.9 and 90%, respectively. A CHA2DS2VASc score65 years, LA enlargement, CHA2DS2VASC score≥2 and presence of SVC on 24-hour Holter are predictive factors of AF in patients with ESUS.

Published
2018

27. Preventing Recurrences: Classic and Modern Antiarrhythmic Drugs in Atrial Fibrillation

Author

Toquero Ramos Jorge, Fernández Lozano Ignacio, and Castro Urda Víctor

Subjects
Proarrhythmia, Inotrope, medicine.medical_specialty, business.industry, Atrial fibrillation, General Medicine, medicine.disease, Drug treatment, Quality of life, Internal medicine, Toxicity, medicine, Cardiology, In patient, business, Adverse effect
Abstract

Medication for atrial fibrillation (AF) with antiarrhythmic drugs (AAD) has been in use for almost 100 years and today remains an essential part of the treatment in patients with this condition. The goals of drug treatment include reducing the number, duration and symptoms of atrial fibrillation episodes, reducing mortality and hospitalizations as well as improving the patients’ quality of life. AAD use is limited by adverse effects which include proarrhythmia, negative inotropic and non-cardiovascular toxicity. The efficacy of these drugs is limited, which means that there are other invasive options that are clearly more effective for symptomatic control of patients.

Published
2014

30. Comprehensive Genetic Characterization of a Spanish Brugada Syndrome Cohort

Author

Selga, Elisabet, primary, Campuzano, Oscar, additional, Pinsach-Abuin, Mel·lina, additional, Pérez-Serra, Alexandra, additional, Mademont-Soler, Irene, additional, Riuró, Helena, additional, Picó, Ferran, additional, Coll, Mònica, additional, Iglesias, Anna, additional, Pagans, Sara, additional, Sarquella-Brugada, Georgia, additional, Berne, Paola, additional, Benito, Begoña, additional, Brugada, Josep, additional, Porres, José M., additional, López Zea, Matilde, additional, Castro-Urda, Víctor, additional, Fernández-Lozano, Ignacio, additional, and Brugada, Ramon, additional

Published
2015
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31. Arritmias ventriculares en superrespondedores a la terapia de resincronización cardiaca

Author

García-Lunar, Inés, primary, Castro-Urda, Víctor, additional, Toquero-Ramos, Jorge, additional, Mingo-Santos, Susana, additional, Moñivas-Palomero, Vanessa, additional, Daniela Mitroi, Cristina, additional, Sánchez-García, Manuel, additional, Pérez-Pereira, Elena, additional, Delgado, Hugo E., additional, and Fernández-Lozano, Ignacio, additional

Published
2014
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32. Genetic analysis, in silico prediction, and family segregation in long QT syndrome

Author

Riuró, Helena, primary, Campuzano, Oscar, additional, Berne, Paola, additional, Arbelo, Elena, additional, Iglesias, Anna, additional, Pérez-Serra, Alexandra, additional, Coll-Vidal, Mònica, additional, Partemi, Sara, additional, Mademont-Soler, Irene, additional, Picó, Ferran, additional, Allegue, Catarina, additional, Oliva, Antonio, additional, Gerstenfeld, Edward, additional, Sarquella-Brugada, Georgia, additional, Castro-Urda, Víctor, additional, Fernández-Lozano, Ignacio, additional, Mont, Lluís, additional, Brugada, Josep, additional, Scornik, Fabiana S, additional, and Brugada, Ramon, additional

Published
2014
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34. A Novel Missense Mutation, I890T, in the Pore Region of Cardiac Sodium Channel Causes Brugada Syndrome

Author

Tarradas, Anna, primary, Selga, Elisabet, additional, Beltran-Alvarez, Pedro, additional, Pérez-Serra, Alexandra, additional, Riuró, Helena, additional, Picó, Ferran, additional, Iglesias, Anna, additional, Campuzano, Oscar, additional, Castro-Urda, Víctor, additional, Fernández-Lozano, Ignacio, additional, Pérez, Guillermo J., additional, Scornik, Fabiana S., additional, and Brugada, Ramon, additional

Published
2013
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39. PET/CT with 18 F-FDG in suspected intracardiac device-related infections: analysis of performance and diagnostic usefulness.

Author

Rodríguez-Alfonso B, Mitjavila Casanovas M, Castro Urda V, Cobo Marcos M, Sánchez Romero I, and Ramos-Martínez A

Subjects
Endocarditis diagnostic imaging, Endocarditis etiology, Fluorodeoxyglucose F18, Humans, Prosthesis-Related Infections diagnosis, Radiopharmaceuticals, Retrospective Studies, Positron Emission Tomography Computed Tomography
Abstract

Introduction and Objectives: Cardiac device-related infections (CDRI) may be life-threatening and require early and accurate diagnosis. The aims of this study were to analyze the performance of positron emission tomography-computed tomography (PET/CT) in suspected CDRI, to assess changes to the initial diagnosis, and to identify a clinical subgroup deriving the greatest benefit from this imaging modality., Methods: Retrospective study including patients evaluated by PET/CT for suspected CDRI from 2011 to 2018. We assessed PET/CT performance and the agreement between the initial, post-PET and definitive diagnoses. We also assessed changes in the diagnosis, depending on initial clinical suspicion, to identify patients deriving the greatest benefit from PET/CT., Results: We included 44 patients. The prevalence of endocarditis was 57%. The sensitivity and specificity of PET/CT for the diagnosis of infective endocarditis were 0.84 and 0.95, respectively. Post-PET diagnosis improved the initial diagnosis by 45%. PET/CT correctly reclassified 57% of patients with initial suspicion of generator pocket infection by detecting lead infection., Conclusions: PET/CT showed high diagnostic performance in suspected of CDRI and significantly improved the conventional diagnostic approach, especially in patients with initial suspicion of focal infection., (Copyright © 2020 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.)

Published
2021
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