1. Interaction of FTO rs9939609 and the native American-origin ABCA1 p.Arg230Cys with circulating leptin levels in Mexican adolescents diagnosed with eating disorders: Preliminary results.
- Author
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Genis-Mendoza AD, Martínez-Magaña JJ, Ruiz-Ramos D, Gonzalez-Covarrubias V, Tovilla-Zarate CA, Narvaez MLL, Castro TBG, Juárez-Rojop IE, and Nicolini H
- Subjects
- Adolescent, Biomarkers blood, Feeding and Eating Disorders blood, Feeding and Eating Disorders diagnosis, Female, Humans, Leptin blood, Male, Mexico epidemiology, Obesity blood, Obesity diagnosis, Obesity genetics, Polymorphism, Single Nucleotide genetics, ATP Binding Cassette Transporter 1 genetics, Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics, Epistasis, Genetic genetics, Feeding and Eating Disorders genetics, Leptin genetics, American Indian or Alaska Native genetics
- Abstract
Eating disorders (ED) are characterized by disruption of eating behaviour and alteration of food intake. Leptin, is one of the main hormones that modulate food intake and are altered in individuals diagnosed with ED. Genetic risk variants for obesity, like those reported inFTO and ABCA1, have also been associated to ED disorders. The present study aimed to analysed leptin circulating levels and the interaction between obesity-risk variants in FTO and ABCA1, in adolescents diagnosed with ED. A total of 99 individuals diagnosed with ED were genotype using Taqman probes for FTO (rs9939609) and ABCA1 (p.Arg230Cys, rs9282541). Commercial enzyme-linked immunosorbent assays were utilized to determined circulating leptin. Differences in leptin concentration were analysed by t-Student or ANOVA test. Gene-gene interaction were analysed using general estimation equations. Circulating leptin levels differed between the three diagnostic groups, lead by individuals diagnosed with binge eating-disorder. In individuals with more than 3 of episodes of binge-eating per week having the highest leptin levels. Also, we found that carriers of both risk alleles had the highest leptin levels. Our observations found an interaction between FTO rs9969609 and the native American-origin ABCA1 p.Arg230Cys to modulate circulating leptin levels in Mexican adolescents diagnosed with eating-disorders., Competing Interests: Declaration of Competing Interests The authors declare no conflict of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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